TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 620.737 | Formula: C37H40N4O5
H donors: 3 H acceptors: 6 LogP: 1.13 Rotable bonds: 13
Rule of 5 violations (Lipinski): 2
SMILES: O=C(/C(=C/c1cccnc1)/c1ccccc1)NCCCCN1CCN(CC1)C(c1ccccc1)c1ccccc1.OC(=O)C(=O)O
InChi: 1S/C35H38N4O.C2H2O4/c40-35(33(30-14-4-1-5-15-30)27-29-13-12-20-36-28-29)37-21-10-11-22-38-23-25-39(26-24-38)34(31-16-6-2-7-17-31)32-18-8-3-9-19-32;3-1(4)2(5)6/h1-9,12-20,27-28,34H,10-11,21-26H2,(H,37,40);(H,3,4)(H,5,6)/b33-27+;
InChiKey: INWVMTRFEQDOFX-GCHSRREBSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	beta tubulin	0.0347	0.4914	1
Echinococcus granulosus	tubulin subunit beta	0.0347	0.4914	0.4914
Giardia lamblia	Epsilon tubulin	0.0084	0.0876	0.1781
Echinococcus granulosus	Tubulin alpha 1 chain	0.0276	0.3825	0.3825
Trichomonas vaginalis	conserved hypothetical protein	0.0055	0.0432	0.0878
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0035	0.0123	0.0125
Leishmania major	beta tubulin	0.0347	0.4914	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0109	0.1267	0.2578
Echinococcus granulosus	tubulin gamma 1 chain	0.0193	0.2559	0.2559
Onchocerca volvulus		0.0083	0.0855	0.3832
Leishmania major	beta tubulin	0.0347	0.4914	1
Trypanosoma cruzi	beta tubulin, putative	0.0347	0.4914	1
Schistosoma mansoni	hypothetical protein	0.0193	0.2552	0.5193
Giardia lamblia	3-hydroxy-3-methylglutaryl-coenzyme A reductase	0.0063	0.055	0.1118
Echinococcus multilocularis	hydroxymethylglutaryl coenzyme A reductase	0.0134	0.1643	0.167
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0276	0.3825	0.3889
Echinococcus granulosus	geminin	0.0193	0.2552	0.2552
Trypanosoma brucei	epsilon tubulin	0.0193	0.2559	0.5207
Brugia malayi	Tubulin alpha chain	0.0276	0.3825	0.581
Brugia malayi	Latrophilin receptor protein 2	0.0035	0.0123	0.0186
Echinococcus multilocularis	tubulin delta chain	0.0084	0.0876	0.089
Entamoeba histolytica	tubulin alpha-1 chain	0.0276	0.3825	0.7783
Brugia malayi	Tubulin alpha-2 chain	0.0276	0.3825	0.581
Echinococcus granulosus	tubulin alpha chain	0.0276	0.3825	0.3825
Onchocerca volvulus		0.0172	0.2231	1
Echinococcus granulosus	GPCR family 2	0.0035	0.0123	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0855	0.1739
Leishmania major	alpha tubulin	0.0276	0.3825	0.7783
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0347	0.4914	1
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0748	0.1522
Brugia malayi	hypothetical protein	0.0172	0.2231	0.3389
Trypanosoma brucei	zeta tubulin	0.0084	0.0876	0.1781
Brugia malayi	Animal haem peroxidase family protein	0.0083	0.0855	0.1298
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0123	0.0249
Trypanosoma cruzi	tubulin delta chain	0.0084	0.0876	0.1781
Echinococcus granulosus	Tubulin beta 2C chain	0.0347	0.4914	0.4914
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0051	0.037	0.0561
Trichomonas vaginalis	tubulin gamma chain, putative	0.0084	0.0876	0.1781
Trichomonas vaginalis	tubulin beta chain, putative	0.0276	0.3825	0.7783
Loa Loa (eye worm)	animal heme peroxidase	0.0083	0.0855	0.1739
Entamoeba histolytica	tubulin alpha chain, putative	0.0276	0.3825	0.7783
Trichomonas vaginalis	tubulin alpha chain, putative	0.0193	0.2559	0.5207
Schistosoma mansoni	hypothetical protein	0.0076	0.0748	0.1522
Onchocerca volvulus	Calmodulin homolog	0.0027	0	0.0002
Echinococcus granulosus	beta tubulin	0.0347	0.4914	0.4914
Onchocerca volvulus		0.0083	0.0855	0.3832
Loa Loa (eye worm)	tubulin gamma chain	0.0193	0.2559	0.5207
Loa Loa (eye worm)	alpha-tubulin	0.0276	0.3825	0.7783
Trypanosoma brucei	beta tubulin	0.0347	0.4914	1
Trypanosoma cruzi	tubulin gamma chain	0.0193	0.2559	0.5207
Trypanosoma cruzi	epsilon tubulin, putative	0.0193	0.2559	0.5207
Schistosoma mansoni	tubulin subunit beta	0.0347	0.4914	1
Brugia malayi	CHE-14 protein	0.0055	0.0432	0.0655
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0276	0.3825	0.7783
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0855	0.1739
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0063	0.055	0.1118
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0432	0.0878
Brugia malayi	tubulin alpha-2 chain	0.0276	0.3825	0.581
Leishmania major	alpha tubulin	0.0276	0.3825	0.7783
Echinococcus granulosus	tubulin alpha 1C chain	0.0276	0.3825	0.3825
Loa Loa (eye worm)	tubulin beta chain	0.0347	0.4914	1
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0063	0.055	0.1118
Trichomonas vaginalis	tubulin beta-1 chain, putative	0.0084	0.0876	0.1781
Echinococcus multilocularis	peroxisome assembly protein 26	0.0276	0.3825	0.3889
Brugia malayi	Serotonin receptor	0.0455	0.6583	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0055	0.0432	0.0432
Toxoplasma gondii	beta-tubulin, putative	0.0347	0.4914	1
Schistosoma mansoni	tubulin subunit alpha	0.0276	0.3825	0.7783
Schistosoma mansoni	tubulin subunit alpha	0.0276	0.3825	0.7783
Trypanosoma brucei	tubulin gamma chain	0.0193	0.2559	0.5207
Onchocerca volvulus	Peroxidasin homolog	0.0083	0.0855	0.3832
Brugia malayi	Blistered cuticle protein 3	0.0083	0.0855	0.1298
Schistosoma mansoni	tubulin subunit beta	0.0347	0.4914	1
Plasmodium vivax	tubulin beta chain, putative	0.0347	0.4914	1
Trypanosoma brucei	alpha tubulin	0.0276	0.3825	0.7783
Schistosoma mansoni	tubulin subunit beta	0.0347	0.4914	1
Leishmania major	alpha tubulin	0.0276	0.3825	0.7783
Schistosoma mansoni	hypothetical protein	0.0035	0.0123	0.0249
Schistosoma mansoni	hydroxymethylglutaryl-CoA reductase (NADPH)	0.0134	0.1643	0.3343
Loa Loa (eye worm)	tubulin beta-1 chain	0.0347	0.4914	1
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0166	0.2142	0.4357
Loa Loa (eye worm)	beta-tubulin	0.0347	0.4914	1
Brugia malayi	hypothetical protein	0.0083	0.0855	0.1298
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0276	0.3825	0.7783
Schistosoma mansoni	tubulin subunit gamma	0.0193	0.2559	0.5207
Trichomonas vaginalis	tubulin beta chain, putative	0.0109	0.1267	0.2578
Trypanosoma cruzi	alpha tubulin, putative	0.0276	0.3825	0.7783
Echinococcus multilocularis	tubulin alpha chain	0.0276	0.3825	0.3889
Loa Loa (eye worm)	hypothetical protein	0.0166	0.2142	0.4357
Echinococcus multilocularis	Tubulin beta 2C chain	0.0347	0.4914	0.4997
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.037	0.037
Trichomonas vaginalis	tubulin beta chain, putative	0.0276	0.3825	0.7783
Leishmania major	beta tubulin	0.0347	0.4914	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.0276	0.3825	0.3825
Schistosoma mansoni	tubulin subunit beta	0.0347	0.4914	1
Brugia malayi	tubulin alpha chain - mouse	0.0276	0.3825	0.581
Onchocerca volvulus	Dual oxidase homolog	0.0083	0.0855	0.3832
Trypanosoma cruzi	zeta tubulin, putative	0.0084	0.0876	0.1781
Trichomonas vaginalis	tubulin beta chain, putative	0.0347	0.4914	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0347	0.4914	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0276	0.3825	0.7783
Trypanosoma brucei	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.0134	0.1643	0.3343
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0084	0.0876	0.1781
Loa Loa (eye worm)	tubulin alpha chain	0.0276	0.3825	0.7783
Onchocerca volvulus	Peroxidase homolog	0.0083	0.0855	0.3832
Loa Loa (eye worm)	BEN-1 protein	0.0347	0.4914	1
Echinococcus multilocularis	protein dispatched 1	0.0055	0.0432	0.0439
Schistosoma mansoni	hypothetical protein	0.0035	0.0123	0.0249
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0063	0.055	0.1118
Schistosoma mansoni	hypothetical protein	0.0193	0.2552	0.5193
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0109	0.1267	0.2578
Leishmania major	alpha tubulin	0.0276	0.3825	0.7783
Leishmania major	alpha tubulin	0.0276	0.3825	0.7783
Schistosoma mansoni	alpha tubulin	0.0276	0.3825	0.7783
Echinococcus multilocularis	GPCR, family 2	0.0035	0.0123	0.0125
Loa Loa (eye worm)	BEN-1 protein	0.0347	0.4914	1
Echinococcus multilocularis	tubulin alpha 3 chain	0.0276	0.3825	0.3889
Echinococcus multilocularis	tubulin subunit TubB	0.0276	0.3825	0.3889
Echinococcus multilocularis	geminin	0.0193	0.2552	0.2595
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0055	0.0432	0.0878
Plasmodium vivax	tubulin alpha chain, putative	0.0276	0.3825	0.7783
Trypanosoma brucei	beta tubulin	0.0193	0.2559	0.5207
Brugia malayi	Animal haem peroxidase family protein	0.0083	0.0855	0.1298
Trichomonas vaginalis	conserved hypothetical protein	0.0084	0.0876	0.1781
Loa Loa (eye worm)	tubulin alpha 2	0.0192	0.2533	0.5154
Leishmania major	epsilon tubulin, putative	0.0193	0.2559	0.5207
Brugia malayi	Tubulin gamma chain	0.0193	0.2559	0.3887
Loa Loa (eye worm)	tubulin alpha 2	0.0082	0.085	0.1729
Schistosoma mansoni	tubulin subunit delta	0.0084	0.0876	0.1781
Echinococcus granulosus	tubulin alpha	0.0193	0.2559	0.2559
Mycobacterium leprae	cell division protein FtsZ	0.0084	0.0876	0.5
Loa Loa (eye worm)	tubulin beta chain	0.0084	0.0876	0.1781
Loa Loa (eye worm)	hypothetical protein	0.0172	0.2231	0.454
Trichomonas vaginalis	tubulin alpha chain, putative	0.0347	0.4914	1
Echinococcus multilocularis	tubulin alpha chain	0.0276	0.3825	0.3889
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0055	0.0432	0.0878
Echinococcus granulosus	tubulin alpha 3 chain	0.0276	0.3825	0.3825
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0855	0.1739
Loa Loa (eye worm)	tubulin alpha 2	0.0192	0.2533	0.5154
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0276	0.3825	0.3889
Leishmania major	beta tubulin	0.0347	0.4914	1
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0192	0.2533	0.5154
Loa Loa (eye worm)	animal heme peroxidase	0.0083	0.0855	0.1739
Onchocerca volvulus	Peroxidasin homolog	0.0083	0.0855	0.3832
Giardia lamblia	Beta tubulin	0.0347	0.4914	1
Brugia malayi	Animal haem peroxidase family protein	0.0083	0.0855	0.1298
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0855	0.1739
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0084	0.0876	0.1781
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.037	0.0752
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0035	0.0123	0.0125
Echinococcus multilocularis	beta tubulin	0.0347	0.4914	0.4997
Echinococcus granulosus	tubulin alpha chain	0.0276	0.3825	0.3825
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0035	0.0123	0.0123
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.037	0.037
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0276	0.3825	0.3889
Echinococcus granulosus	Tubulin beta 2C chain	0.0347	0.4914	0.4914
Trypanosoma brucei	zeta tubulin, putative	0.0084	0.0876	0.1781
Echinococcus granulosus	sterol regulatory element binding protein	0.0055	0.0432	0.0432
Leishmania major	beta tubulin	0.0347	0.4914	1
Trypanosoma brucei	alpha tubulin	0.0276	0.3825	0.7783
Echinococcus granulosus	Tubulin beta 2C chain	0.0347	0.4914	0.4914
Loa Loa (eye worm)	tubulin beta-4 chain	0.0347	0.4914	1
Trypanosoma brucei	beta tubulin	0.0347	0.4914	1
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0855	0.1739
Loa Loa (eye worm)	tubulin alpha chain	0.0276	0.3825	0.7783
Echinococcus multilocularis	tubulin alpha chain	0.0276	0.3825	0.3889
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0193	0.2559	0.5207
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1643	0.3343
Echinococcus granulosus	tubulin alpha chain	0.0276	0.3825	0.3825
Trichomonas vaginalis	tubulin gamma chain, putative	0.0347	0.4914	1
Plasmodium vivax	delta tubulin, putative	0.0084	0.0876	0.1781
Loa Loa (eye worm)	hypothetical protein	0.0192	0.2533	0.5154
Echinococcus multilocularis	peroxidasin	0.0083	0.0855	0.0869
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0111	0.1287	0.1955
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0111	0.1287	0.2619
Leishmania major	alpha tubulin	0.0276	0.3825	0.7783
Echinococcus multilocularis	tubulin epsilon chain	0.0193	0.2559	0.2602
Plasmodium falciparum	alpha tubulin 2	0.0276	0.3825	0.7783
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.037	0.0376
Plasmodium falciparum	tubulin beta chain	0.0347	0.4914	1
Schistosoma mansoni	tubulin subunit beta	0.0347	0.4914	1
Echinococcus multilocularis	tubulin alpha chain	0.0276	0.3825	0.3889
Echinococcus granulosus	tubulin alpha chain	0.0276	0.3825	0.3825
Echinococcus multilocularis	tubulin beta 1 chain	0.0347	0.4914	0.4997
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0855	0.1739
Leishmania major	beta tubulin	0.0347	0.4914	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0136	0.1675	0.3409
Echinococcus granulosus	Tubulin alpha 1 chain	0.0276	0.3825	0.3825
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0192	0.2533	0.5154
Echinococcus multilocularis	Tubulin beta 2C chain	0.0347	0.4914	0.4997
Schistosoma mansoni	tubulin subunit alpha	0.0084	0.0876	0.1781
Schistosoma mansoni	tubulin subunit beta	0.0347	0.4914	1
Trypanosoma brucei	epsilon tubulin	0.0193	0.2559	0.5207
Trichomonas vaginalis	tubulin, putative	0.0347	0.4914	1
Brugia malayi	Tubulin alpha chain	0.0084	0.0876	0.133
Leishmania major	beta tubulin	0.0347	0.4914	1
Brugia malayi	Animal haem peroxidase family protein	0.0083	0.0855	0.1298
Schistosoma mansoni	hypothetical protein	0.0035	0.0123	0.0249
Echinococcus granulosus	peroxidasin	0.0083	0.0855	0.0855
Loa Loa (eye worm)	animal heme peroxidase	0.0083	0.0855	0.1739
Echinococcus granulosus	beta tubulin	0.0347	0.4914	0.4914
Plasmodium vivax	tubulin gamma chain, putative	0.0193	0.2559	0.5207
Leishmania major	3-hydroxy-3-methylglutaryl-CoA reductase	0.0134	0.1643	0.3343
Trichomonas vaginalis	conserved hypothetical protein	0.0084	0.0876	0.1781
Brugia malayi	Hydroxymethylglutaryl-coenzyme A reductase family protein	0.0134	0.1643	0.2495
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0855	0.1739
Leishmania major	alpha tubulin	0.0276	0.3825	0.7783
Echinococcus multilocularis	tubulin alpha 1C chain	0.0276	0.3825	0.3889
Giardia lamblia	Alpha-tubulin	0.0276	0.3825	0.7783
Trichomonas vaginalis	tubulin, putative	0.0109	0.1267	0.2578
Trypanosoma cruzi	zeta tubulin, putative	0.0084	0.0876	0.1781
Trypanosoma brucei	alpha tubulin	0.0276	0.3825	0.7783
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0111	0.1287	0.1955
Leishmania major	beta tubulin	0.0347	0.4914	1
Echinococcus granulosus	peroxisome assembly protein 26	0.0276	0.3825	0.3825
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0035	0.0123	0.0123
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0166	0.2142	0.4357
Brugia malayi	latrophilin 2 splice variant baaae	0.0076	0.0748	0.1136
Entamoeba histolytica	tubulin family protein	0.0347	0.4914	1
Loa Loa (eye worm)	hypothetical protein	0.0276	0.3825	0.7783
Echinococcus multilocularis	Tubulin beta 2C chain	0.0347	0.4914	0.4997
Trypanosoma brucei	epsilon tubulin	0.0193	0.2559	0.5207
Brugia malayi	alpha-tubulin	0.0276	0.3825	0.581
Toxoplasma gondii	alpha-tubulin I, putative	0.0276	0.3825	0.7783
Brugia malayi	Cell division protein ftsZ	0.0084	0.0876	0.133
Echinococcus multilocularis	hypothetical protein	0.0276	0.3825	0.3889
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.037	0.0376
Trichomonas vaginalis	tubulin gamma chain, putative	0.0193	0.2559	0.5207
Trichomonas vaginalis	tubulin beta chain, putative	0.0276	0.3825	0.7783
Trypanosoma cruzi	tubulin delta chain	0.0084	0.0876	0.1781
Schistosoma mansoni	peroxidasin	0.0083	0.0855	0.1739
Brugia malayi	Animal haem peroxidase family protein	0.0083	0.0855	0.1298
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0276	0.3825	0.7783
Echinococcus multilocularis	tubulin alpha 3 chain	0.0276	0.3825	0.3889
Plasmodium vivax	tubulin epsilon chain, putative	0.0193	0.2559	0.5207
Echinococcus multilocularis	tubulin alpha	0.0193	0.2559	0.2602
Plasmodium falciparum	tubulin delta chain, putative	0.0084	0.0876	0.1781
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0855	0.1739
Treponema pallidum	ATP-binding protein (ylxH-1)	0.0493	0.7165	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.037	0.0752
Leishmania major	beta tubulin	0.0347	0.4914	1
Echinococcus granulosus	tubulin alpha 1C chain	0.0276	0.3825	0.3825
Echinococcus multilocularis	conserved hypothetical protein	0.0667	0.9835	1
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1287	0.2619
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0855	0.1739
Loa Loa (eye worm)	tubulin beta-2A chain	0.0347	0.4914	1
Echinococcus granulosus	tubulin beta 1 chain	0.0347	0.4914	0.4914
Loa Loa (eye worm)	blistered cuticle protein 3	0.0083	0.0855	0.1739
Echinococcus granulosus	Tubulin beta 2C chain	0.0347	0.4914	0.4914
Echinococcus multilocularis	tubulin alpha 1C chain	0.0276	0.3825	0.3889
Brugia malayi	MH2 domain containing protein	0.0136	0.1675	0.2545
Giardia lamblia	Beta tubulin	0.0347	0.4914	1
Leishmania major	delta tubulin, putative	0.0084	0.0876	0.1781
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0084	0.0876	0.1781
Schistosoma mansoni	alpha tubulin	0.0276	0.3825	0.7783
Giardia lamblia	Gamma tubulin	0.0193	0.2559	0.5207
Leishmania major	beta tubulin	0.0347	0.4914	1
Schistosoma mansoni	hypothetical protein	0.0035	0.0123	0.0249
Trichomonas vaginalis	tubulin beta chain, putative	0.0276	0.3825	0.7783
Brugia malayi	Tubulin alpha-2 chain	0.0276	0.3825	0.581
Giardia lamblia	Delta tubulin	0.0084	0.0876	0.1781
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0855	0.1739
Echinococcus granulosus	alpha tubulin	0.0276	0.3825	0.3825
Echinococcus granulosus	hydroxymethylglutaryl coenzyme A reductase	0.0134	0.1643	0.1643
Leishmania major	beta tubulin	0.0347	0.4914	1
Loa Loa (eye worm)	alpha-tubulin	0.0276	0.3825	0.7783
Trichomonas vaginalis	tubulin beta chain, putative	0.0276	0.3825	0.7783
Leishmania major	beta tubulin	0.0347	0.4914	1
Mycobacterium tuberculosis	Cell division protein FtsZ	0.0084	0.0876	0.5
Onchocerca volvulus	Chorion peroxidase homolog	0.0083	0.0855	0.3832
Echinococcus granulosus	Protein patched homolog 1	0.0055	0.0432	0.0432
Giardia lamblia	Alpha-tubulin	0.0276	0.3825	0.7783
Echinococcus granulosus	tubulin epsilon chain	0.0193	0.2559	0.2559
Trichomonas vaginalis	tubulin alpha chain, putative	0.0109	0.1267	0.2578
Trichomonas vaginalis	tubulin alpha chain, putative	0.0109	0.1267	0.2578
Leishmania major	beta tubulin	0.0347	0.4914	1
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0855	0.1739
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.0134	0.1643	0.3343
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0347	0.4914	0.4997
Leishmania major	alpha tubulin	0.0276	0.3825	0.7783
Schistosoma mansoni	peroxidasin	0.0083	0.0855	0.1739
Trypanosoma brucei	alpha tubulin	0.0276	0.3825	0.7783
Giardia lamblia	Beta tubulin	0.0347	0.4914	1
Trichomonas vaginalis	tubulin, putative	0.0084	0.0876	0.1781
Plasmodium falciparum	tubulin epsilon chain, putative	0.0193	0.2559	0.5207
Onchocerca volvulus	Peroxidase homolog	0.0083	0.0855	0.3832
Plasmodium falciparum	alpha tubulin 1	0.0276	0.3825	0.7783
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase	0.0134	0.1643	0.3343
Echinococcus multilocularis	beta tubulin	0.0347	0.4914	0.4997
Schistosoma mansoni	tubulin subunit alpha	0.0276	0.3825	0.7783
Toxoplasma gondii	beta tubulin	0.0347	0.4914	1
Entamoeba histolytica	tubulin gamma chain	0.0193	0.2559	0.5207
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0035	0.0123	0.0249
Schistosoma mansoni	alpha tubulin	0.0276	0.3825	0.7783
Echinococcus multilocularis	sterol regulatory element binding protein	0.0055	0.0432	0.0439
Mycobacterium ulcerans	hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase	0.0134	0.1643	1
Entamoeba histolytica	tubulin family protein	0.0347	0.4914	1
Toxoplasma gondii	alpha tubulin TUBA1	0.0276	0.3825	0.7783
Schistosoma mansoni	patched 1	0.0055	0.0432	0.0878
Echinococcus granulosus	tubulin alpha chain	0.0276	0.3825	0.3825
Leishmania major	beta tubulin	0.0347	0.4914	1
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0855	0.1739
Brugia malayi	Tubulin beta-1 chain	0.0347	0.4914	0.7465
Trypanosoma brucei	beta tubulin	0.0347	0.4914	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.0055	0.0432	0.0439
Trypanosoma cruzi	epsilon tubulin, putative	0.0193	0.2559	0.5207
Onchocerca volvulus		0.0109	0.1267	0.568
Loa Loa (eye worm)	transcription factor SMAD2	0.0136	0.1675	0.3409
Echinococcus multilocularis	Tubulin beta 2C chain	0.0347	0.4914	0.4997
Brugia malayi	Peroxidasin	0.0083	0.0855	0.1298
Echinococcus granulosus	tubulin beta 4A class IVa	0.0347	0.4914	0.4914
Trypanosoma brucei	tubulin delta chain	0.0084	0.0876	0.1781
Schistosoma mansoni	tubulin subunit beta	0.0084	0.0876	0.1781
Echinococcus multilocularis	tubulin alpha chain	0.0276	0.3825	0.3889
Echinococcus granulosus	Tubulin beta 2C chain	0.0347	0.4914	0.4914
Trichomonas vaginalis	tubulin gamma chain, putative	0.0193	0.2559	0.5207
Leishmania major	beta tubulin	0.0347	0.4914	1
Leishmania major	zeta tubulin, putative	0.0084	0.0876	0.1781
Echinococcus granulosus	tubulin alpha 3 chain	0.0276	0.3825	0.3825
Loa Loa (eye worm)	animal heme peroxidase	0.0083	0.0855	0.1739
Echinococcus multilocularis	protein patched	0.0055	0.0432	0.0439
Plasmodium vivax	tubulin alpha chain, putative	0.0276	0.3825	0.7783
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0855	0.1739
Echinococcus granulosus	tubulin subunit TubB	0.0276	0.3825	0.3825
Leishmania major	alpha tubulin	0.0276	0.3825	0.7783
Brugia malayi	beta-tubulin, identical	0.0347	0.4914	0.7465
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0855	0.1739
Echinococcus granulosus	tubulin delta chain	0.0084	0.0876	0.0876
Echinococcus multilocularis	tubulin gamma 1 chain	0.0193	0.2559	0.2602
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.037	0.0752
Leishmania major	gamma-tubulin	0.0193	0.2559	0.5207
Trypanosoma brucei	alpha tubulin, putative	0.0109	0.1267	0.2578
Toxoplasma gondii	beta-1 tubulin, putative	0.0347	0.4914	1
Schistosoma mansoni	tubulin subunit epsilon	0.0193	0.2559	0.5207
Brugia malayi	Tubulin beta chain	0.0084	0.0876	0.133
Leishmania major	beta tubulin	0.0347	0.4914	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0035	0.0123	0.0186
Echinococcus multilocularis	tubulin subunit beta	0.0347	0.4914	0.4997
Leishmania major	beta tubulin	0.0347	0.4914	1
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0084	0.0876	0.5
Leishmania major	alpha tubulin	0.0276	0.3825	0.7783
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0051	0.037	0.0752
Leishmania major	alpha tubulin	0.0276	0.3825	0.7783
Onchocerca volvulus		0.0083	0.0855	0.3832
Trichomonas vaginalis	tubulin, putative	0.0109	0.1267	0.2578
Plasmodium falciparum	tubulin gamma chain	0.0193	0.2559	0.5207
Brugia malayi	Tubulin beta chain	0.0109	0.1267	0.1925
Echinococcus multilocularis	Tubulin beta 2C chain	0.0347	0.4914	0.4997
Trichomonas vaginalis	tubulin beta chain, putative	0.0276	0.3825	0.7783
Leishmania major	alpha tubulin	0.0276	0.3825	0.7783
Leishmania major	beta tubulin	0.0347	0.4914	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)	= 58 %	Antiallergic activity determined by passive cutaneous anaphylaxis assay upon peroral administration of 20 mg/kg in rat	ChEMBL.	2465410

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 267806