Detailed information for compound 274689

Basic information

Technical information
  • TDR Targets ID: 274689
  • Name: (2R,3R,4S)-3-acetamido-2-(dipropylcarbamoyl)- 4-(ethylamino)-3,4-dihydro-2H-pyran-6-carboxy lic acid
  • MW: 355.429 | Formula: C17H29N3O5
  • H donors: 3 H acceptors: 4 LogP: -0.95 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN[C@H]1C=C(O[C@H]([C@@H]1NC(=O)C)C(=O)N(CCC)CCC)C(=O)O
  • InChi: 1S/C17H29N3O5/c1-5-8-20(9-6-2)16(22)15-14(19-11(4)21)12(18-7-3)10-13(25-15)17(23)24/h10,12,14-15,18H,5-9H2,1-4H3,(H,19,21)(H,23,24)/t12-,14+,15+/m0/s1
  • InChiKey: BZVDPXGVFDPKBR-NWANDNLSSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2R,3R,4S)-3-acetamido-2-[(dipropylamino)-oxomethyl]-4-(ethylamino)-3,4-dihydro-2H-pyran-6-carboxylic acid
  • (4S,5R,6R)-5-acetamido-6-(dipropylcarbamoyl)-4-ethylamino-5,6-dihydro-4H-pyran-2-carboxylic acid
  • (4S,5R,6R)-5-acetamido-6-[(dipropylamino)-oxomethyl]-4-ethylamino-5,6-dihydro-4H-pyran-2-carboxylic acid
  • (4S,5R,6R)-5-Acetylamino-6-dipropylcarbamoyl-4-ethylamino-5,6-dihydro-4H-pyran-2-carboxylic acid
  • AIDS-121687
  • AIDS121687

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Influenza A virus (A/Puerto Rico/8/1934(H1N1)) Neuraminidase Starlite/ChEMBL References
Influenza B virus (strain B/Lee/1940) Neuraminidase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei hypothetical protein, conserved Get druggable targets OG5_136729 All targets in OG5_136729
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_136729 All targets in OG5_136729
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 Get druggable targets OG5_136729 All targets in OG5_136729
Trypanosoma congolense hypothetical protein, conserved Get druggable targets OG5_136729 All targets in OG5_136729
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 Get druggable targets OG5_136729 All targets in OG5_136729
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_136729 All targets in OG5_136729
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 Get druggable targets OG5_136729 All targets in OG5_136729
Trypanosoma brucei hypothetical protein, conserved Get druggable targets OG5_136729 All targets in OG5_136729
Trypanosoma congolense hypothetical protein, conserved Get druggable targets OG5_136729 All targets in OG5_136729
Trypanosoma congolense hypothetical protein, conserved Get druggable targets OG5_136729 All targets in OG5_136729
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 Get druggable targets OG5_136729 All targets in OG5_136729
Trypanosoma brucei Enriched in surface-labeled proteome protein 12 Get druggable targets OG5_136729 All targets in OG5_136729
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_136729 All targets in OG5_136729
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 Get druggable targets OG5_136729 All targets in OG5_136729
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_136729 All targets in OG5_136729
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica deoxycytidyl transferase, putative 0.0013 0.0117 0.1598
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0013 0.0124 0.443
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0007 0.0009 0.0009
Brugia malayi kinase, mitochondrial precursor 0.0375 0.6697 1
Echinococcus granulosus geminin 0.0258 0.4569 0.6822
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0008 0.0026 0.0026
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.001 0.008 0.008
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0021 0.0268 0.0981
Schistosoma mansoni smad1 5 8 and 0.0013 0.0119 0.0178
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.001 0.008 0.0119
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0007 0.0009 0.0013
Schistosoma mansoni hypothetical protein 0.0011 0.0096 0.0144
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0062 0.1011 0.151
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0117 0.0161
Schistosoma mansoni terminal deoxycytidyl transferase 0.0013 0.0117 0.0175
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0021 0.0274 0.0396
Brugia malayi MH2 domain containing protein 0.0013 0.0119 0.0166
Schistosoma mansoni tar DNA-binding protein 0.0043 0.0679 0.1014
Leishmania major heat shock protein 83-1 0.0021 0.0268 0.0387
Schistosoma mansoni hypothetical protein 0.0011 0.0096 0.0144
Echinococcus granulosus sodium:myo inositol cotransporter 0.0025 0.0342 0.0511
Brugia malayi TAR-binding protein 0.0043 0.0679 0.1002
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0117 0.0161
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.001 0.008 0.008
Leishmania major heat shock protein 83-1 0.0021 0.0268 0.0387
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0021 0.0268 0.0388
Loa Loa (eye worm) transcription factor SMAD2 0.0186 0.3267 0.4872
Trichomonas vaginalis rotamase, putative 0.0021 0.0274 0.0655
Schistosoma mansoni tar DNA-binding protein 0.0043 0.0679 0.1014
Leishmania major hypothetical protein, conserved 0.0021 0.0268 0.0387
Echinococcus granulosus mothers against decapentaplegic 5 0.0013 0.0119 0.0178
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0013 0.0124 0.2336
Loa Loa (eye worm) hypothetical protein 0.0021 0.0268 0.0388
Trypanosoma brucei Heat shock protein 83, putative 0.0021 0.0268 0.0387
Leishmania major heat shock protein 83-1 0.0021 0.0268 0.0387
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0007 0.0009 0.0009
Toxoplasma gondii isocitrate dehydrogenase 0.001 0.008 0.0268
Trypanosoma brucei DNA topoisomerase ii 0.0021 0.0268 0.0387
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.005 0.0803 0.0803
Echinococcus multilocularis tar DNA binding protein 0.0043 0.0679 0.0679
Echinococcus multilocularis thyroid hormone receptor alpha 0.0007 0.0009 0.0009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0062 0.1011 0.151
Leishmania major heat shock protein 83-1 0.0021 0.0268 0.0387
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0375 0.6697 0.6697
Echinococcus multilocularis geminin 0.0258 0.4569 0.4569
Loa Loa (eye worm) hypothetical protein 0.0025 0.0342 0.0499
Brugia malayi Pre-SET motif family protein 0.0179 0.3135 0.4675
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0007 0.0009 0.0009
Schistosoma mansoni tar DNA-binding protein 0.0043 0.0679 0.1014
Schistosoma mansoni hypothetical protein 0.0011 0.0096 0.0144
Trypanosoma brucei heat shock protein, putative 0.0021 0.0268 0.0387
Trypanosoma brucei unspecified product 0.0009 0.0046 0.0056
Echinococcus multilocularis cpg binding protein 0.0022 0.0288 0.0288
Toxoplasma gondii heat shock protein HSP90 0.0021 0.0268 0.0981
Leishmania major heat shock protein 83-1 0.0021 0.0268 0.0387
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0021 0.0268 0.5
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0013 0.0117 0.1973
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0007 0.0009 0.0013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0193 0.0276
Loa Loa (eye worm) Smad1 0.0013 0.0119 0.0166
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0021 0.0268 0.0725
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0013 0.0124 0.0453
Loa Loa (eye worm) hypothetical protein 0.0226 0.3997 0.5964
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0013 0.0124 0.1558
Trichomonas vaginalis rotamase, putative 0.0022 0.0283 0.0681
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0026 0.0362 0.0362
Echinococcus granulosus histone lysine methyltransferase setb 0.0026 0.0362 0.054
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0021 0.0268 0.5
Trypanosoma brucei heat shock protein, putative 0.0021 0.0268 0.0387
Loa Loa (eye worm) MH2 domain-containing protein 0.0013 0.0119 0.0166
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0021 0.0268 1
Toxoplasma gondii DNA topoisomerase 2, putative 0.0021 0.0268 0.0981
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0021 0.0268 0.0387
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0021 0.0268 1
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0131 0.2269 0.3379
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0021 0.0268 1
Entamoeba histolytica hypothetical protein 0.0023 0.0314 0.5815
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0021 0.0268 0.0725
Loa Loa (eye worm) MH1 domain-containing protein 0.0013 0.0119 0.0166
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0021 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0375 0.6697 1
Schistosoma mansoni coup transcription factor 0.0007 0.0009 0.0013
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0008 0.0042 0.0049
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0117 0.0161
Brugia malayi isocitrate dehydrogenase 0.001 0.008 0.0106
Echinococcus granulosus ecdysone induced protein 78C 0.0007 0.0009 0.0013
Giardia lamblia Pms1-like protein 0.0021 0.0268 1
Schistosoma mansoni sodium/solute symporter 0.0025 0.0342 0.0511
Trypanosoma brucei heat shock protein, putative 0.0021 0.0268 0.0387
Loa Loa (eye worm) hypothetical protein 0.0026 0.0362 0.0528
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0007 0.0009 0.0013
Trypanosoma cruzi heat shock protein 85, putative 0.0021 0.0268 0.0387
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0013 0.0124 0.1744
Trypanosoma brucei heat shock protein, putative 0.0021 0.0268 0.0387
Brugia malayi Latrophilin receptor protein 2 0.0011 0.0096 0.0131
Schistosoma mansoni thyroid hormone receptor 0.0007 0.0009 0.0013
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0016 0.0181 0.0258
Trypanosoma brucei DNA polymerase kappa, putative 0.0009 0.0046 0.0056
Brugia malayi MH1 domain containing protein 0.0007 0.0016 0.0012
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0124 0.2148 0.3198
Loa Loa (eye worm) MH2 domain-containing protein 0.0186 0.3267 0.4872
Onchocerca volvulus 0.0025 0.0342 0.0934
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0021 0.0268 1
Echinococcus granulosus smad 0.0013 0.0119 0.0178
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0021 0.0268 0.0388
Echinococcus granulosus sodium:glucose cotransporter 2 0.0025 0.0342 0.0511
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0021 0.0268 0.0387
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0007 0.0009 0.0009
Mycobacterium ulcerans DNA gyrase subunit B 0.0021 0.0268 1
Mycobacterium tuberculosis Possible two component sensor kinase 0.0021 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0268 0.0388
Echinococcus multilocularis FTZ F1 alpha 0.0007 0.0009 0.0009
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0021 0.0268 1
Entamoeba histolytica DNA topoisomerase II, putative 0.0021 0.0268 0.4822
Leishmania major heat shock protein 83-1 0.0021 0.0268 0.0387
Trypanosoma brucei DNA polymerase kappa, putative 0.0009 0.0046 0.0056
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0026 0.0362 0.054
Brugia malayi RNA recognition motif domain containing protein 0.0043 0.0679 0.1002
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0021 0.0268 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0117 0.0161
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0013 0.0117 0.0175
Schistosoma mansoni retinoic acid receptor RXR 0.0007 0.0009 0.0013
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0025 0.0342 0.0342
Echinococcus granulosus dna polymerase eta 0.0013 0.0117 0.0175
Brugia malayi Sodium:solute symporter family protein 0.0025 0.0342 0.0499
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0011 0.0096 0.0131
Onchocerca volvulus 0.0026 0.0362 0.0988
Plasmodium falciparum DNA gyrase subunit B 0.0021 0.0268 1
Mycobacterium leprae Probable two-component sensor kinase 0.0021 0.0268 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0117 0.0161
Schistosoma mansoni ap endonuclease 0.0013 0.0124 0.0185
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.0362 0.054
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0023 0.0314 0.0469
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.001 0.008 0.0119
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0124 0.2148 0.3198
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0021 0.0268 0.0387
Trichomonas vaginalis hypothetical protein 0.0024 0.0334 0.0825
Toxoplasma gondii histone lysine methyltransferase SET1 0.004 0.0621 0.2319
Trypanosoma brucei heat shock protein, putative 0.0021 0.0268 0.0387
Plasmodium vivax DNA topoisomerase II, putative 0.0021 0.0268 0.667
Mycobacterium ulcerans two component regulator - sensor kinase 0.0021 0.0268 1
Echinococcus multilocularis smad 0.0013 0.0119 0.0119
Trypanosoma brucei heat shock protein, putative 0.0021 0.0268 0.0387
Entamoeba histolytica hypothetical protein 0.0023 0.0314 0.5815
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0179 0.3135 0.4675
Loa Loa (eye worm) TAR-binding protein 0.0043 0.0679 0.1002
Schistosoma mansoni inositol transporter 0.0025 0.0342 0.0511
Entamoeba histolytica heat shock protein 90, putative 0.0021 0.0268 0.4822
Onchocerca volvulus 0.0021 0.0266 0.0721
Schistosoma mansoni heat shock protein 0.0021 0.0268 0.04
Echinococcus multilocularis mothers against decapentaplegic 5 0.0013 0.0119 0.0119
Leishmania major heat shock protein 83-1 0.0021 0.0268 0.0387
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0268 0.667
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0013 0.0124 0.0453
Plasmodium vivax endoplasmin, putative 0.0021 0.0268 0.667
Echinococcus granulosus dna polymerase kappa 0.0013 0.0117 0.0175
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0021 0.0268 0.0638
Brugia malayi hypothetical protein 0.0017 0.0193 0.0276
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0013 0.0124 0.0171
Leishmania major heat shock protein 83-1 0.0021 0.0268 0.0387
Trypanosoma brucei isocitrate dehydrogenase, putative 0.001 0.008 0.0106
Brugia malayi Calcitonin receptor-like protein seb-1 0.0036 0.0544 0.08
Leishmania major heat shock protein 83-1 0.0021 0.0268 0.0387
Schistosoma mansoni RAR-like nuclear receptor 0.0007 0.0009 0.0013
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0021 0.0268 1
Leishmania major DNA polymerase eta, putative 0.0013 0.0117 0.0161
Plasmodium falciparum heat shock protein 90 0.0021 0.0268 1
Brugia malayi ImpB/MucB/SamB family protein 0.0013 0.0117 0.0162
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.001 0.008 0.0106
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0021 0.0268 0.0387
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0021 0.0268 1
Toxoplasma gondii peptidylprolyl isomerase 0.0021 0.0274 0.1004
Trypanosoma brucei DNA polymerase IV, putative 0.0013 0.0117 0.0161
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0375 0.6697 1
Schistosoma mansoni pyruvate dehydrogenase 0.0354 0.6318 0.9435
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0021 0.0268 0.0387
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.001 0.008 0.0106
Plasmodium vivax DNA gyrase subunit B, putative 0.0021 0.0268 0.667
Schistosoma mansoni tsg101-related 0.0042 0.065 0.097
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0045 0.0706 0.1055
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.001 0.008 0.008
Trichomonas vaginalis ap endonuclease, putative 0.0013 0.0124 0.0231
Trypanosoma cruzi DNA polymerase kappa, putative 0.0013 0.0117 0.0161
Echinococcus granulosus cpg binding protein 0.0022 0.0288 0.043
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0016 0.0181 0.0258
Schistosoma mansoni Smad4 0.0013 0.0119 0.0178
Brugia malayi Isocitrate dehydrogenase 0.001 0.008 0.0106
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0022 0.0283 0.0411
Trypanosoma cruzi Heat shock protein 83, putative 0.0021 0.0268 0.0387
Trypanosoma cruzi DNA polymerase kappa, putative 0.0013 0.0117 0.0161
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0021 0.0268 1
Schistosoma mansoni high-affinity choline transporter 0.0226 0.3997 0.5969
Leishmania major heat shock protein 83-1 0.0021 0.0268 0.0387
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0025 0.0342 0.1263
Trichomonas vaginalis set domain proteins, putative 0.0203 0.3582 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0117 0.0161
Echinococcus granulosus Smad4 0.0013 0.0119 0.0178
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0117 0.0161
Loa Loa (eye worm) RNA binding protein 0.0043 0.0679 0.1002
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0021 0.0268 1
Brugia malayi MH1 domain containing protein 0.0013 0.0119 0.0166
Loa Loa (eye worm) hypothetical protein 0.0011 0.0096 0.0131
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0007 0.0009 0.0013
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.001 0.008 0.008
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0007 0.0009 0.0009
Echinococcus multilocularis high affinity choline transporter 1 0.0226 0.3997 0.3997
Echinococcus multilocularis Smad4 0.0013 0.0119 0.0119
Schistosoma mansoni rotamase 0.0022 0.0283 0.0423
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0008 0.0042 0.0049
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0021 0.0268 1
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0021 0.0274 0.0396
Echinococcus multilocularis dna polymerase eta 0.0013 0.0117 0.0117
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0013 0.0124 0.0171
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0007 0.0009 0.0013
Schistosoma mansoni tar DNA-binding protein 0.0043 0.0679 0.1014
Loa Loa (eye worm) hypothetical protein 0.005 0.0803 0.1187
Plasmodium falciparum ataxin-2 like protein, putative 0.0017 0.0193 0.6029
Brugia malayi Pre-SET motif family protein 0.0026 0.0362 0.0528
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0008 0.0026 0.0038
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.001 0.008 0.0106
Echinococcus multilocularis solute carrier family 5 0.0025 0.0342 0.0342
Leishmania major heat shock protein 83-1 0.0021 0.0268 0.0387
Mycobacterium ulcerans two component sensor kinase MprB 0.0021 0.0268 1
Brugia malayi MH1 domain containing protein 0.0013 0.0119 0.0166
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0007 0.0009 0.0013
Loa Loa (eye worm) hypothetical protein 0.0013 0.0117 0.0162
Trypanosoma brucei heat shock protein, putative 0.0021 0.0268 0.0387
Schistosoma mansoni smad1 5 8 and 0.0013 0.0119 0.0178
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0026 0.0362 0.1337
Trypanosoma brucei unspecified product 0.0013 0.0117 0.0161
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.0362 0.054
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0062 0.1011 0.1011
Echinococcus multilocularis expressed protein 0.0022 0.0283 0.0283
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0043 0.0679 0.1002
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0008 0.0042 0.0049
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0007 0.0009 0.0013
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0021 0.0268 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0023 0.0023
Leishmania major DNA polymerase kappa, putative 0.0013 0.0117 0.0161
Entamoeba histolytica hypothetical protein 0.0023 0.0314 0.5815
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0021 0.0268 0.0387
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0131 0.2269 0.3379
Loa Loa (eye worm) TOPoisomerase family member 0.0021 0.0268 0.0388
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0062 0.1011 0.1499
Toxoplasma gondii exonuclease III APE 0.0013 0.0124 0.0435
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0007 0.0009 0.0013
Trypanosoma brucei PAB1-binding protein , putative 0.0017 0.0193 0.0275
Leishmania major heat shock protein 83-1 0.0021 0.0268 0.0387
Loa Loa (eye worm) isocitrate dehydrogenase 0.001 0.008 0.0106
Echinococcus granulosus tar DNA binding protein 0.0043 0.0679 0.1014
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0022 0.0283 0.0411
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0023 0.0314 0.0314
Echinococcus multilocularis ecdysone induced protein 78C 0.0007 0.0009 0.0009
Brugia malayi RNA binding protein 0.0043 0.0679 0.1002
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0375 0.6697 1
Schistosoma mansoni pyruvate dehydrogenase 0.0375 0.6697 1
Trichomonas vaginalis DNA topoisomerase II, putative 0.0021 0.0268 0.0638
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0013 0.0117 0.0211
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0008 0.0042 0.0049
Leishmania major heat shock protein 83-1 0.0021 0.0268 0.0387
Brugia malayi CXXC zinc finger family protein 0.0021 0.0266 0.0385
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0021 0.0268 1
Schistosoma mansoni pyruvate dehydrogenase 0.0354 0.6318 0.9435
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0007 0.0009 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0117 0.0161
Trichomonas vaginalis receptor histidine kinase, putative 0.0021 0.0268 0.0638
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0021 0.0268 0.0638
Brugia malayi Endoplasmin precursor 0.0021 0.0268 0.0388
Trypanosoma brucei DNA polymerase IV, putative 0.0013 0.0117 0.0161
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0008 0.0042 0.0049
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0062 0.1011 0.1499
Trypanosoma brucei hypothetical protein, conserved 0.0124 0.2148 0.3198
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0021 0.0268 0.0725
Schistosoma mansoni hypothetical protein 0.0008 0.0026 0.0038
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0124 0.2148 0.3198
Plasmodium vivax SET domain protein, putative 0.0026 0.0362 1
Schistosoma mansoni DNA topoisomerase II 0.0021 0.0268 0.04
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0011 0.0096 0.0096
Echinococcus granulosus TGF beta signal transducer SmadC 0.0013 0.0119 0.0178
Loa Loa (eye worm) hypothetical protein 0.0025 0.0337 0.0491
Trypanosoma cruzi DNA polymerase eta, putative 0.0013 0.0117 0.0161
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0021 0.0268 0.0981
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0021 0.0268 0.0268
Plasmodium vivax heat shock protein 86, putative 0.0021 0.0268 0.667
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0013 0.0117 0.0175
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0042 0.0049
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0036 0.0544 0.08
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0013 0.0124 0.0172
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0007 0.0009 0.0013
Trypanosoma cruzi PAB1-binding protein , putative 0.0017 0.0193 0.0275
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0008 0.0042 0.0049
Schistosoma mansoni smad1 5 8 and 0.0013 0.0119 0.0178
Plasmodium falciparum endoplasmin, putative 0.0021 0.0268 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0021 0.0274 0.0396
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0021 0.0268 1
Schistosoma mansoni thyroid hormone receptor 0.0007 0.0009 0.0013
Schistosoma mansoni steroid hormone receptor ad4bp 0.0007 0.0009 0.0013
Plasmodium falciparum ataxin-2 like protein, putative 0.0017 0.0193 0.6029
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0021 0.0268 0.5
Trypanosoma cruzi DNA polymerase kappa, putative 0.0013 0.0117 0.0161
Brugia malayi MH2 domain containing protein 0.0186 0.3267 0.4872
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0062 0.1011 0.151
Entamoeba histolytica hypothetical protein 0.0023 0.0314 0.5815
Brugia malayi exodeoxyribonuclease III family protein 0.0013 0.0124 0.0172
Loa Loa (eye worm) nuclear factor I 0.0007 0.0016 0.0012
Leishmania major heat shock protein 83-1 0.0021 0.0268 0.0387
Schistosoma mansoni cpg binding protein 0.0022 0.0288 0.043
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0008 0.0042 0.0049
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0021 0.0268 1
Schistosoma mansoni endoplasmin 0.0021 0.0268 0.04
Echinococcus granulosus expressed protein 0.0022 0.0283 0.0423
Trypanosoma brucei heat shock protein, putative 0.0021 0.0268 0.0387
Schistosoma mansoni transcription factor LCR-F1 0.0023 0.0314 0.0469
Trypanosoma brucei developmentally regulated phosphoprotein 0.0375 0.6697 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.0362 0.054
Schistosoma mansoni inositol transporter 0.0025 0.0342 0.0511
Trypanosoma cruzi heat shock protein 90, putative 0.0021 0.0268 0.0387
Chlamydia trachomatis DNA gyrase subunit B 0.0021 0.0268 0.5
Toxoplasma gondii heat shock protein 90, putative 0.0021 0.0268 0.0981
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0036 0.0544 0.08
Toxoplasma gondii LsmAD domain-containing protein 0.0017 0.0193 0.0698
Brugia malayi Smad1 0.0013 0.0119 0.0166
Brugia malayi hypothetical protein 0.0023 0.0314 0.0457
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0013 0.0119 0.0119
Brugia malayi MH2 domain containing protein 0.0013 0.0119 0.0166
Echinococcus granulosus heat shock protein 0.0021 0.0268 0.04
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0062 0.1011 0.151
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0025 0.0342 0.0342
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0021 0.0268 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0013 0.0117 0.0211
Schistosoma mansoni cpg binding protein 0.0022 0.0288 0.043
Echinococcus granulosus high affinity choline transporter 1 0.0226 0.3997 0.5969
Schistosoma mansoni nuclear hormone receptor 0.0007 0.0009 0.0013
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0013 0.0117 0.0162
Mycobacterium tuberculosis Conserved hypothetical protein 0.0013 0.0117 0.1973
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0007 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.0011 0.0096 0.0144
Brugia malayi hypothetical protein 0.0011 0.0085 0.0115
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0062 0.1011 0.1011
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0131 0.2269 0.8565
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0007 0.0009 0.0013
Schistosoma mansoni tsg101-related 0.0042 0.065 0.097
Echinococcus multilocularis heat shock protein 90 0.0021 0.0268 0.0268
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0042 0.0049
Brugia malayi heat shock protein 90 0.0021 0.0268 0.0388
Trypanosoma cruzi heat shock protein 90, putative 0.0021 0.0268 0.0387
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0013 0.0124 0.0185
Schistosoma mansoni hypothetical protein 0.0296 0.5261 0.7856
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0013 0.0117 0.0117
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0023 0.0034
Loa Loa (eye worm) hypothetical protein 0.0036 0.0544 0.08
Echinococcus multilocularis isocitrate dehydrogenase 0.001 0.008 0.008
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0124 0.2148 0.3198
Trypanosoma cruzi DNA topoisomerase II, putative 0.0021 0.0268 0.0387
Echinococcus granulosus sodium:glucose cotransporter 0.0025 0.0342 0.0511
Mycobacterium ulcerans putative regultory protein 0.0021 0.0268 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0011 0.0096 0.0144
Schistosoma mansoni smad 0.0013 0.0119 0.0178
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0021 0.0268 1
Leishmania major DNA topoisomerase ii 0.0021 0.0268 0.0387
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0011 0.0096 0.0096
Echinococcus multilocularis GPCR, family 2 0.0011 0.0096 0.0096
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0008 0.0042 0.0049
Echinococcus granulosus GPCR family 2 0.0011 0.0096 0.0144
Leishmania major heat shock protein 83-1 0.0021 0.0268 0.0387
Trypanosoma brucei DNA polymerase kappa, putative 0.0009 0.0046 0.0056
Plasmodium vivax ataxin-2 like protein, putative 0.0017 0.0193 0.4021
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0021 0.0268 1
Schistosoma mansoni hypothetical protein 0.0258 0.4569 0.6822
Trypanosoma brucei heat shock protein 90, putative 0.0021 0.0268 0.0387
Brugia malayi GH02984p 0.0226 0.3997 0.5964
Entamoeba histolytica heat shock protein 90, putative 0.0021 0.0268 0.4822
Leishmania major developmentally regulated phosphoprotein-like protein 0.0375 0.6697 1
Loa Loa (eye worm) heat shock protein 90 0.0021 0.0268 0.0388
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0021 0.0268 1
Trypanosoma cruzi DNA topoisomerase II, putative 0.0021 0.0268 0.0387
Schistosoma mansoni cpg binding protein 0.0021 0.0266 0.0398
Echinococcus granulosus tumor susceptibility gene 101 protein 0.005 0.0803 0.1198
Schistosoma mansoni DNA polymerase eta 0.0013 0.0117 0.0175
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0026 0.0362 0.0362
Echinococcus granulosus heat shock protein 90 0.0021 0.0268 0.04
Echinococcus multilocularis dnaJ subfamily B 0.0296 0.5261 0.5261
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0025 0.0337 0.0502
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0013 0.0117 0.0161
Trichomonas vaginalis endoplasmin, putative 0.0021 0.0268 0.0638
Trichomonas vaginalis heat shock protein, putative 0.0021 0.0268 0.0638
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0011 0.0096 0.0144
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0008 0.0042 0.0049
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0034 0.051 1
Trichomonas vaginalis heat shock protein, putative 0.0021 0.0268 0.0638
Schistosoma mansoni heat shock protein 0.0021 0.0268 0.04
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0375 0.6697 0.6697
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.001 0.008 0.0106
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0021 0.0268 0.0638
Brugia malayi Probable DNA topoisomerase II 0.0021 0.0268 0.0388
Echinococcus multilocularis dna polymerase kappa 0.0013 0.0117 0.0117
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0117 0.0161
Trypanosoma cruzi PAB1-binding protein , putative 0.0017 0.0193 0.0275
Echinococcus multilocularis heat shock protein 0.0021 0.0268 0.0268
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0021 0.0268 0.0638
Brugia malayi ImpB/MucB/SamB family protein 0.0013 0.0117 0.0162
Loa Loa (eye worm) histone methyltransferase 0.0007 0.0023 0.0021
Trichomonas vaginalis ap endonuclease, putative 0.0013 0.0124 0.0231
Schistosoma mansoni tsg101-related 0.0034 0.051 0.0762
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0117 0.0161
Onchocerca volvulus 0.0203 0.3582 1
Trypanosoma brucei DNA polymerase IV, putative 0.0013 0.0117 0.0161
Echinococcus granulosus dnaJ subfamily B 0.0296 0.5261 0.7856
Mycobacterium tuberculosis Probable two component sensor kinase 0.0021 0.0268 1
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0021 0.0268 1
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0021 0.0268 1
Chlamydia trachomatis DNA gyrase subunit B 0.0021 0.0268 0.5
Mycobacterium leprae Probable two component sensor kinase MprB 0.0021 0.0268 0.5
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0013 0.0124 0.0171
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0021 0.0268 1
Mycobacterium tuberculosis Conserved protein 0.0021 0.0268 1
Trypanosoma brucei hypothetical protein, conserved 0.0124 0.2148 0.3198
Brugia malayi MH1 domain containing protein 0.0007 0.0016 0.0012
Loa Loa (eye worm) hypothetical protein 0.0007 0.0016 0.0012
Schistosoma mansoni hypothetical protein 0.0023 0.0314 0.0469
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0021 0.0274 0.0396
Brugia malayi F/Y-rich N-terminus family protein 0.0007 0.0022 0.0019
Leishmania major heat shock protein 83-1 0.0021 0.0268 0.0387
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0013 0.0124 0.0171
Echinococcus granulosus solute carrier family 5 0.0025 0.0342 0.0511
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0124 0.2148 0.3198
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0025 0.0342 0.0511
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0008 0.0042 0.0049
Schistosoma mansoni tar DNA-binding protein 0.0043 0.0679 0.1014
Brugia malayi latrophilin 2 splice variant baaae 0.0025 0.0337 0.0491
Schistosoma mansoni hypothetical protein 0.0258 0.4569 0.6822
Trichomonas vaginalis receptor histidine kinase, putative 0.0021 0.0268 0.0638
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0021 0.0268 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0013 0.0119 0.0178
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0021 0.0268 0.0638
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0021 0.0268 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0013 0.0117 0.0161
Trypanosoma cruzi heat shock protein 85, putative 0.0021 0.0268 0.0387
Trichomonas vaginalis sensor histidine kinase, putative 0.0021 0.0268 0.0638
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0013 0.0124 0.0124
Brugia malayi hypothetical protein 0.005 0.0803 0.1187
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0007 0.0009 0.0013
Schistosoma mansoni endoplasmin 0.0021 0.0268 0.04
Loa Loa (eye worm) latrophilin receptor protein 2 0.0011 0.0096 0.0131
Trypanosoma brucei Enriched in surface-labeled proteome protein 12 0.0124 0.2148 0.3198
Loa Loa (eye worm) endoplasmin 0.0021 0.0268 0.0388
Echinococcus granulosus FTZ F1 alpha 0.0007 0.0009 0.0013
Leishmania major hypothetical protein, conserved 0.0017 0.0193 0.0275
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0131 0.2269 0.3379
Trypanosoma cruzi heat shock protein 85, putative 0.0021 0.0268 0.0387
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0283 0.0681
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0021 0.0268 0.04
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0152 0.2648 1
Schistosoma mansoni ap endonuclease 0.0013 0.0124 0.0185
Leishmania major mitochondrial DNA topoisomerase II 0.0021 0.0268 0.0387
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0007 0.0009 0.0013
Trypanosoma brucei heat shock protein 90, putative 0.0021 0.0268 0.0387
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0025 0.0342 0.0342
Schistosoma mansoni hypothetical protein 0.0025 0.0337 0.0503
Giardia lamblia Heat shock protein HSP 90-alpha 0.0021 0.0268 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0013 0.0124 0.2336
Trypanosoma brucei unspecified product 0.0009 0.0046 0.0056
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0008 0.0042 0.0049
Leishmania major hypothetical protein, conserved 0.0016 0.0181 0.0258
Plasmodium falciparum DNA topoisomerase 2 0.0021 0.0268 1
Toxoplasma gondii isocitrate dehydrogenase 0.001 0.008 0.0268
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0062 0.1011 0.151
Leishmania major heat shock protein 83-1 0.0021 0.0268 0.0387
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0021 0.0274 0.4951
Trypanosoma brucei DNA polymerase eta, putative 0.0013 0.0117 0.0161
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0008 0.0042 0.0049
Loa Loa (eye worm) CXXC zinc finger family protein 0.0021 0.0266 0.0385

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 0 ug ml-1 Concentration required for reduction of plaque against influenza A; Not determined ChEMBL. 11266166
IC50 (functional) 0 ug ml-1 Concentration required for reduction of plaque against influenza B; Not determined ChEMBL. 11266166
IC50 (binding) = 0.42 uM Inhibitory activity against influenza A sialidase (Aichi) ChEMBL. 11266166
IC50 (binding) = 0.42 uM Inhibitory activity against influenza A sialidase (Aichi) ChEMBL. 11266166
IC50 (binding) = 4.5 uM Inhibitory activity against influenza B sialidase (Victoria) ChEMBL. 11266166
IC50 (binding) = 4.5 uM Inhibitory activity against influenza B sialidase (Victoria) ChEMBL. 11266166

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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