Detailed information for compound 276547

Basic information

Technical information
  • TDR Targets ID: 276547
  • Name: (1S,2R)-5-methoxy-1-prop-2-enyl-N-propyl-1,2, 3,4-tetrahydronaphthalen-2-amine
  • MW: 259.386 | Formula: C17H25NO
  • H donors: 1 H acceptors: 0 LogP: 3.97 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CC[C@@H]1[C@H](NCCC)CCc2c1cccc2OC
  • InChi: 1S/C17H25NO/c1-4-7-14-13-8-6-9-17(19-3)15(13)10-11-16(14)18-12-5-2/h4,6,8-9,14,16,18H,1,5,7,10-12H2,2-3H3/t14-,16+/m0/s1
  • InChiKey: PGQOLAHSKSOQNB-GOEBONIOSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (1S,2R)-1-allyl-5-methoxy-N-propyl-tetralin-2-amine
  • (1S,2R)-1-allyl-5-methoxy-N-propyl-2-tetralinamine
  • [(1S,2R)-1-allyl-5-methoxy-tetralin-2-yl]-propyl-amine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum expressed protein Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma mansoni biogenic amine (5HT) receptor Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum Octopamine receptor, putative Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus granulosus biogenic amine 5HT receptor Get druggable targets OG5_133249 All targets in OG5_133249
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis expressed conserved protein 0.0108 0.0496 0.0992
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0134 0.1209
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0073 0.0315 0.0594
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.003 0.0095 0.0432
Trypanosoma cruzi DNA topoisomerase II, putative 0.0062 0.0259 0.048
Echinococcus multilocularis phosphoglycerate kinase 1 0.0199 0.0964 0.1927
Mycobacterium ulcerans heat shock protein 90 0.003 0.0095 0.0526
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0046 0.028
Giardia lamblia Pyruvate kinase 0.0039 0.014 0.1061
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0249 0.0461
Loa Loa (eye worm) hypothetical protein 0.003 0.0092 0.0092
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0012 0.0003 0.0006
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0062 0.0259 0.2261
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0151 0.0661
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0134 0.0992
Schistosoma mansoni ap endonuclease 0.0022 0.0052 0.0105
Mycobacterium tuberculosis Conserved protein 0.0037 0.0129 0.0676
Schistosoma mansoni SET domain protein 0.0038 0.0137 0.0273
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0002
Mycobacterium ulcerans pyruvate kinase 0.0039 0.014 0.0843
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0034 0.0068
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0983 0.5003 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0021 0.002
Mycobacterium leprae Probable two-component sensor kinase 0.0062 0.0259 0.2002
Schistosoma mansoni heat shock protein 0.0092 0.0414 0.0828
Mycobacterium ulcerans beta-lactamase 0.0037 0.0129 0.0767
Trichomonas vaginalis DNA polymerase eta, putative 0.006 0.0249 0.2432
Trypanosoma brucei heat shock protein, putative 0.0092 0.0414 0.0793
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0082 0.0126
Brugia malayi Fli-1 protein 0.0257 0.1263 0.2525
Mycobacterium tuberculosis Conserved hypothetical protein 0.0034 0.0113 0.0559
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0012 0.0002 0.0005
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0062 0.0259 0.1596
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0158 0.0753 0.5116
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0052 0.035
Trypanosoma brucei pyruvate kinase 1, putative 0.0039 0.014 0.0242
Giardia lamblia Pms1-like protein 0.0062 0.0259 0.2346
Loa Loa (eye worm) hypothetical protein 0.0037 0.0129 0.013
Trypanosoma cruzi DNA polymerase eta, putative 0.0034 0.0113 0.0188
Echinococcus granulosus phosphoglycerate kinase 1 0.0199 0.0964 0.1927
Leishmania major developmentally regulated phosphoprotein-like protein 0.0983 0.5003 1
Echinococcus multilocularis microtubule associated protein 2 0.0806 0.4095 0.8184
Echinococcus multilocularis geminin 0.0164 0.0783 0.1564
Loa Loa (eye worm) pyruvate kinase 0.0039 0.014 0.014
Loa Loa (eye worm) TOPoisomerase family member 0.0062 0.0259 0.0259
Trypanosoma cruzi heat shock protein 85, putative 0.0092 0.0414 0.0793
Brugia malayi DNA-binding protein D-ETS-3 0.0012 0.0002 0.0005
Trichomonas vaginalis receptor histidine kinase, putative 0.0062 0.0259 0.2531
Trypanosoma brucei phosphoglycerate kinase 0.0073 0.0315 0.0594
Echinococcus multilocularis dna polymerase eta 0.0034 0.0113 0.0225
Schistosoma mansoni heat shock protein 0.0092 0.0414 0.0828
Loa Loa (eye worm) transcription factor SMAD2 0.014 0.0658 0.066
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0062 0.0259 0.2531
Giardia lamblia DINP protein human, muc B family 0.004 0.0147 0.1132
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0062 0.0259 0.1678
Loa Loa (eye worm) hypothetical protein 0.0983 0.5003 0.5015
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0034 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0194 0.1844
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0062 0.0259 0.2531
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0246 0.2399
Leishmania major hypothetical protein, conserved 0.0062 0.0259 0.048
Chlamydia trachomatis DNA gyrase subunit B 0.0062 0.0259 0.2316
Chlamydia trachomatis phosphoglycerate kinase 0.0199 0.0964 1
Entamoeba histolytica pyruvate kinase, putative 0.0027 0.0079 0.0634
Schistosoma mansoni hypothetical protein 0.0012 0.0002 0.0005
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0144 0.0289
Leishmania major heat shock protein 83-1 0.0092 0.0414 0.0793
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0082 0.0164
Schistosoma mansoni chromobox protein 0.0067 0.0286 0.0572
Trichomonas vaginalis heat shock protein, putative 0.003 0.0095 0.0801
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0062 0.0259 0.1678
Echinococcus granulosus GPCR family 2 0.0018 0.0034 0.0068
Echinococcus granulosus ETS transcription factor Elf 1 0.0012 0.0002 0.0005
Trypanosoma cruzi pyruvate kinase 2, putative 0.0039 0.014 0.0242
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0062 0.0259 0.1678
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0062 0.0259 0.1678
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0129 0.0676
Schistosoma mansoni hypothetical protein 0.0013 0.0007 0.0014
Onchocerca volvulus 0.0037 0.0129 0.0129
Trypanosoma brucei heat shock protein 90, putative 0.0092 0.0414 0.0793
Leishmania major pyruvate kinase 0.0039 0.014 0.0242
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.003 0.0095 0.0148
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0129 0.013
Loa Loa (eye worm) hypothetical protein 0.0037 0.0129 0.013
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0246 0.2399
Schistosoma mansoni DNA polymerase eta 0.0034 0.0113 0.0225
Leishmania major heat shock protein 83-1 0.0092 0.0414 0.0793
Mycobacterium tuberculosis Conserved protein 0.0062 0.0259 0.1596
Trypanosoma brucei Heat shock protein 83, putative 0.0092 0.0414 0.0793
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0091 0.0758
Trypanosoma brucei phosphoglycerate kinase 0.0199 0.0964 0.1896
Echinococcus multilocularis pyruvate kinase 0.002 0.0042 0.0084
Loa Loa (eye worm) hypothetical protein 0.0037 0.0129 0.013
Entamoeba histolytica DNA topoisomerase II, putative 0.0062 0.0259 0.2531
Trypanosoma brucei heat shock protein, putative 0.0092 0.0414 0.0793
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0039 0.014 0.0753
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0115 0.0532 0.5427
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0062 0.0259 0.2002
Echinococcus multilocularis mitogen activated protein kinase 0.006 0.0246 0.0492
Echinococcus granulosus ETS transcription factor Elf 2 0.0012 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.004 0.0144 0.0145
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0129 0.0676
Plasmodium vivax heat shock protein 86, putative 0.0092 0.0414 0.4181
Loa Loa (eye worm) heat shock protein 75 0.0016 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0021 0.0046 0.0046
Leishmania major heat shock protein 83-1 0.0092 0.0414 0.0793
Loa Loa (eye worm) hypothetical protein 0.0021 0.0046 0.0046
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0983 0.5003 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0082 0.0126
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0129 0.1163
Trichomonas vaginalis heat shock protein, putative 0.0078 0.0339 0.338
Brugia malayi kinase, mitochondrial precursor 0.0983 0.5003 1
Echinococcus multilocularis serotonin receptor 0.0154 0.0733 0.1465
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0062 0.0259 0.1596
Echinococcus granulosus ewsr:fli fusion protein type 0.0012 0.0002 0.0005
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0052 0.011
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0034 0.0068
Loa Loa (eye worm) hypothetical protein 0.0058 0.0239 0.024
Brugia malayi Ets-domain containing protein 0.0085 0.0375 0.075
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0062 0.0259 0.0258
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0034 0.003
Echinococcus granulosus peregrin 0.0015 0.0014 0.0028
Echinococcus multilocularis ETS transcription factor Elf 2 0.0012 0.0002 0.0005
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0082 0.0164
Onchocerca volvulus 0.003 0.0092 0.0092
Trichomonas vaginalis heat shock protein, putative 0.003 0.0095 0.0801
Leishmania major heat shock protein 83-1 0.0092 0.0414 0.0793
Trypanosoma cruzi heat shock protein 90, putative 0.0077 0.0334 0.0632
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0062 0.0259 0.0258
Schistosoma mansoni hypothetical protein 0.004 0.0144 0.0289
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.006 0.0246 0.0455
Brugia malayi CHE-14 protein 0.0049 0.0194 0.0387
Brugia malayi chromobox protein homolog 3 0.0038 0.0134 0.0267
Schistosoma mansoni elf1 0.0012 0.0002 0.0005
Schistosoma mansoni hypothetical protein 0.0048 0.0184 0.0369
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0341 0.1696 0.3363
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0062 0.0259 0.0517
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0341 0.1696 0.3363
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0249 0.0461
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0012 0.0002 0.0002
Echinococcus multilocularis peregrin 0.0015 0.0014 0.0028
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0147 0.0255
Treponema pallidum heat shock protein 90 0.003 0.0095 0.0467
Entamoeba histolytica heat shock protein 90, putative 0.0092 0.0414 0.4181
Leishmania major heat shock protein 83-1 0.0092 0.0414 0.0793
Schistosoma mansoni heat shock protein 0.0016 0.0019 0.0039
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0052 0.035
Brugia malayi ImpB/MucB/SamB family protein 0.0034 0.0113 0.0226
Trypanosoma brucei DNA topoisomerase ii 0.0062 0.0259 0.048
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0034 0.0158
Giardia lamblia Phosphoglycerate kinase 0.0199 0.0964 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.006 0.0246 0.0455
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.003 0.0095 0.019
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.0661 0.1321
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0199 0.0964 0.6619
Trichomonas vaginalis esterase, putative 0.0037 0.0129 0.1163
Loa Loa (eye worm) hypothetical protein 0.0154 0.0733 0.0735
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0062 0.0259 0.1198
Schistosoma mansoni SET domain protein 0.0012 0.0003 0.0006
Leishmania major heat shock protein 83-1 0.0092 0.0414 0.0793
Schistosoma mansoni hypothetical protein 0.0018 0.0034 0.0068
Loa Loa (eye worm) hypothetical protein 0.0021 0.0046 0.0046
Trypanosoma cruzi DNA topoisomerase II, putative 0.0062 0.0259 0.048
Schistosoma mansoni phd finger protein 0.0015 0.0014 0.0028
Toxoplasma gondii pyruvate kinase PyKII 0.002 0.0042 0.0115
Echinococcus multilocularis ETS transcription factor Elf 1 0.0012 0.0002 0.0005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.017 0.034
Schistosoma mansoni biogenic amine (5HT) receptor 0.0154 0.0733 0.1465
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0199 0.0964 0.1896
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.003 0.0095 0.0152
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.0641 0.128
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0034 0.0069
Trypanosoma brucei protein kinase, putative 0.006 0.0246 0.0455
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0082 0.0339
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0052 0.0105
Plasmodium vivax DNA gyrase subunit B, putative 0.0062 0.0259 0.2531
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0073 0.0315 0.0594
Plasmodium vivax phosphoglycerate kinase, putative 0.0199 0.0964 1
Mycobacterium tuberculosis Conserved protein 0.0037 0.0129 0.0676
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0129 0.0221
Loa Loa (eye worm) TAR-binding protein 0.0074 0.0321 0.0321
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0199 0.0964 1
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0321 0.0641
Echinococcus granulosus Niemann Pick C1 protein 0.0115 0.0532 0.1063
Trypanosoma brucei phosphoglycerate kinase 0.0199 0.0964 0.1896
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0062 0.0259 0.048
Echinococcus granulosus ETS domain containing protein Elk 1 0.0012 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0037 0.0129 0.013
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0062 0.0259 0.048
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0017 0.0027 0.0038
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0052 0.0066
Trypanosoma cruzi Heat shock protein 83, putative 0.0092 0.0414 0.0793
Echinococcus multilocularis protein C ets 2 0.0012 0.0002 0.0005
Onchocerca volvulus 0.0012 0.0002 0.0002
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0016 0.0019 0.0019
Brugia malayi SET domain containing protein 0.0012 0.0003 0.0005
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0062 0.0259 0.2531
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.006 0.0246 0.0455
Trypanosoma brucei developmentally regulated phosphoprotein 0.0983 0.5003 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0034 0.0113 0.0225
Giardia lamblia Heat shock protein HSP 90-alpha 0.003 0.0095 0.0572
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0038 0.0137 0.0273
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0062 0.0259 0.1596
Onchocerca volvulus 0.0028 0.0082 0.0082
Schistosoma mansoni hypothetical protein 0.0164 0.0783 0.1564
Mycobacterium tuberculosis Probable oxidoreductase 0.0291 0.1439 1
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0012 0.0002 0.0002
Brugia malayi beta-lactamase family protein 0.0037 0.0129 0.0258
Echinococcus granulosus ETS transcription factor Elf 5 0.0012 0.0002 0.0005
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.017 0.034
Echinococcus multilocularis endoplasmin 0.003 0.0095 0.019
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.006 0.0246 0.0455
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0034 0.0075
Mycobacterium tuberculosis Probable two component sensor kinase 0.0062 0.0259 0.1596
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0062 0.0259 0.1678
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0062 0.0259 0.1596
Leishmania major hypothetical protein, conserved 0.0037 0.0129 0.0221
Trichomonas vaginalis pyruvate kinase, putative 0.0039 0.014 0.1277
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.0249 0.0461
Brugia malayi MAP kinase sur-1 0.006 0.0246 0.0492
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.003 0.0095 0.0467
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.017 0.017
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0034 0.003
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0062 0.0259 0.2316
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0321 0.0641
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0021 0.002
Trypanosoma cruzi heat shock protein 90, putative 0.003 0.0095 0.0152
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0062 0.0259 0.2002
Echinococcus granulosus ETS transcription factor Elf 2 0.0012 0.0002 0.0005
Leishmania major phosphoglycerate kinase C, glycosomal 0.0199 0.0964 0.1896
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0073 0.0315 0.0594
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0148 0.1365
Toxoplasma gondii heat shock protein 90, putative 0.0092 0.0414 0.1979
Loa Loa (eye worm) hypothetical protein 0.0143 0.0677 0.0678
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0062 0.0259 0.1596
Schistosoma mansoni hypothetical protein 0.0018 0.0034 0.0068
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0062 0.0259 0.2261
Leishmania major heat shock protein 83-1 0.0092 0.0414 0.0793
Leishmania major heat shock protein 83-1 0.0092 0.0414 0.0793
Mycobacterium leprae Probable two component sensor kinase MprB 0.0062 0.0259 0.2002
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.014 0.014
Leishmania major heat shock protein 83-1 0.0092 0.0414 0.0793
Brugia malayi transcription factor E74 isoform 0.0012 0.0002 0.0005
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.014 0.014
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0062 0.0259 0.1678
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0077 0.0608
Brugia malayi RNA binding protein 0.0074 0.0321 0.0641
Loa Loa (eye worm) hypothetical protein 0.0027 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0143 0.0677 0.0678
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0134 0.1209
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0129 0.0258
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0062 0.0259 0.2261
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0052 0.0105
Echinococcus granulosus Protein patched homolog 1 0.0049 0.0194 0.0387
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0239 0.0479
Loa Loa (eye worm) hypothetical protein 0.0039 0.014 0.014
Echinococcus granulosus pyruvate kinase 0.0039 0.014 0.028
Brugia malayi ImpB/MucB/SamB family protein 0.0034 0.0113 0.0226
Schistosoma mansoni ap endonuclease 0.0022 0.0052 0.0105
Brugia malayi hypothetical protein 0.0019 0.0037 0.0074
Trypanosoma cruzi heat shock protein 85, putative 0.0092 0.0414 0.0793
Trypanosoma brucei DNA polymerase IV, putative 0.0054 0.0215 0.0393
Schistosoma mansoni DNA topoisomerase II 0.0062 0.0259 0.0517
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0073 0.0315 0.0594
Brugia malayi Pyruvate kinase, M2 isozyme 0.0039 0.014 0.028
Echinococcus multilocularis ETS transcription factor Elf 5 0.0012 0.0002 0.0005
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0983 0.5003 1
Brugia malayi Ets-domain containing protein 0.0012 0.0002 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0249 0.0461
Mycobacterium ulcerans two component sensor kinase MprB 0.0062 0.0259 0.1678
Echinococcus granulosus chromobox protein 1 0.0067 0.0286 0.0572
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.006 0.0246 0.0455
Mycobacterium ulcerans two component regulator - sensor kinase 0.0062 0.0259 0.1678
Loa Loa (eye worm) hypothetical protein 0.0072 0.0312 0.0313
Toxoplasma gondii pyruvate kinase PyK1 0.0039 0.014 0.0605
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0016 0.0019 0.0039
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0129 0.0258
Echinococcus multilocularis mitogen activated protein kinase 3 0.006 0.0246 0.0492
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0062 0.0259 0.0258
Loa Loa (eye worm) hypothetical protein 0.0037 0.0129 0.013
Echinococcus granulosus heat shock protein 90 0.003 0.0095 0.019
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0082 0.0433
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0321 0.0641
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.004 0.0041
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0062 0.0259 0.1596
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0129 0.0676
Loa Loa (eye worm) MH2 domain-containing protein 0.014 0.0658 0.066
Loa Loa (eye worm) ets-domain-containing protein 0.0012 0.0002 0.0002
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0052 0.035
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0246 0.2399
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0034 0.003
Echinococcus multilocularis tar DNA binding protein 0.0074 0.0321 0.0641
Brugia malayi Pyruvate kinase, muscle isozyme 0.0039 0.014 0.028
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0007 0.0014
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0148 0.1365
Mycobacterium ulcerans lipase LipD 0.0037 0.0129 0.0767
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0093 0.0147
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0073 0.0315 0.0594
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.0661 0.1321
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0983 0.5003 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0129 0.1163
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.004 0.0041
Echinococcus multilocularis pyruvate kinase 0.002 0.0042 0.0084
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0073 0.0315 0.0594
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0199 0.0964 1
Brugia malayi polk-prov protein 0.0037 0.0129 0.0259
Echinococcus granulosus tar DNA binding protein 0.0074 0.0321 0.0641
Loa Loa (eye worm) hypothetical protein 0.0021 0.0046 0.0046
Schistosoma mansoni microtubule-associated protein tau 0.0806 0.4095 0.8184
Loa Loa (eye worm) RNA binding protein 0.0074 0.0321 0.0321
Toxoplasma gondii heat shock protein HSP90 0.0092 0.0414 0.1979
Loa Loa (eye worm) D-ets-2 protein 0.0012 0.0002 0.0002
Mycobacterium ulcerans phosphoglycerate kinase 0.0199 0.0964 0.6652
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0082 0.0126
Trypanosoma brucei unspecified product 0.0023 0.0059 0.0079
Leishmania major heat shock protein 83-1 0.0092 0.0414 0.0793
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0129 0.0221
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0012 0.0003 0.0006
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0062 0.0259 0.048
Mycobacterium tuberculosis Possible two component sensor kinase 0.0062 0.0259 0.1596
Echinococcus multilocularis heat shock protein 90 0.0092 0.0414 0.0828
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0129 0.0536
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0028 0.0082 0.0433
Loa Loa (eye worm) hypothetical protein 0.0037 0.0129 0.013
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.0249 0.0461
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0034 0.0069
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0199 0.0964 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0034 0.0069
Mycobacterium ulcerans hypothetical protein 0.0037 0.0129 0.0767
Toxoplasma gondii exonuclease III APE 0.0022 0.0052 0.0166
Loa Loa (eye worm) pyruvate kinase-PB 0.0027 0.0079 0.0079
Plasmodium falciparum heat shock protein 90 0.0092 0.0414 0.4181
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0046 0.0179
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0199 0.0964 0.1896
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0246 0.2399
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0062 0.0259 0.1596
Echinococcus granulosus sterol regulatory element binding protein 0.0049 0.0194 0.0387
Echinococcus granulosus pyruvate kinase 0.002 0.0042 0.0084
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0007 0.0014
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.017 0.034
Echinococcus multilocularis Niemann Pick C1 protein 0.0164 0.0787 0.1572
Chlamydia trachomatis DNA gyrase subunit B 0.0062 0.0259 0.2316
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0341 0.1696 0.3363
Plasmodium falciparum pyruvate kinase 0.0039 0.014 0.1277
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0034 0.0068
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0062 0.0259 0.1596
Giardia lamblia Grp94/Hsp90 0.003 0.0095 0.0572
Trypanosoma brucei cytochrome P450, putative 0.0016 0.0021 0.0002
Echinococcus granulosus pyruvate kinase 0.0039 0.014 0.028
Leishmania major phosphoglycerate kinase B, cytosolic 0.0199 0.0964 0.1896
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0034 0.0034
Echinococcus multilocularis dna polymerase kappa 0.006 0.0249 0.0498
Plasmodium falciparum DNA gyrase subunit B 0.0062 0.0259 0.2531
Schistosoma mansoni hypothetical protein 0.0018 0.0034 0.0068
Schistosoma mansoni hypothetical protein 0.0012 0.0002 0.0005
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.0147 0.08
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0129 0.1163
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0034 0.0069
Echinococcus granulosus microtubule associated protein 2 0.0806 0.4095 0.8184
Trypanosoma brucei unspecified product 0.0023 0.0059 0.0079
Loa Loa (eye worm) hypothetical protein 0.0037 0.0129 0.013
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0091 0.0144
Mycobacterium leprae Probable lipase LipE 0.0037 0.0129 0.0536
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0082 0.0433
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0062 0.0259 0.1596
Loa Loa (eye worm) hypothetical protein 0.0062 0.0259 0.0259
Trypanosoma brucei unspecified product 0.0054 0.0215 0.0393
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0052 0.035
Treponema pallidum phosphoglycerate kinase 0.0199 0.0964 1
Trichomonas vaginalis receptor histidine kinase, putative 0.0062 0.0259 0.2531
Onchocerca volvulus 0.0012 0.0003 0.0003
Echinococcus multilocularis serotonin receptor 0.0154 0.0733 0.1465
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0028 0.0082 0.0433
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0249 0.0461
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0062 0.0259 0.1596
Leishmania major DNA polymerase eta, putative 0.0034 0.0113 0.0188
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0034 0.0068
Onchocerca volvulus 0.0037 0.0129 0.0129
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0034 0.0069
Mycobacterium ulcerans DNA gyrase subunit B 0.0062 0.0259 0.1678
Brugia malayi hypothetical protein 0.0029 0.0091 0.0182
Leishmania major cytochrome p450-like protein 0.0016 0.0021 0.0002
Trypanosoma brucei DNA polymerase eta, putative 0.0034 0.0113 0.0188
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0062 0.0259 0.1596
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0012 0.0002 0.0005
Echinococcus granulosus endoplasmin 0.003 0.0095 0.019
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0148 0.0148
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0129 0.1163
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0134 0.0134
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0249 0.0461
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0062 0.0259 0.2531
Echinococcus multilocularis pyruvate kinase 0.002 0.0042 0.0084
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0286 0.2822
Trypanosoma brucei heat shock protein, putative 0.0092 0.0414 0.0793
Echinococcus granulosus GA binding protein alpha chain 0.0085 0.0375 0.075
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0091 0.0144
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.006 0.0246 0.1136
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0034 0.0069
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0117 0.0541 0.1082
Loa Loa (eye worm) hypothetical protein 0.0028 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0115 0.0532 0.0533
Loa Loa (eye worm) hypothetical protein 0.006 0.0251 0.0251
Echinococcus granulosus neuropeptide s receptor 0.0545 0.2746 0.5488
Brugia malayi Ets-domain containing protein 0.0085 0.0375 0.075
Echinococcus granulosus dna polymerase kappa 0.006 0.0249 0.0498
Toxoplasma gondii ABC1 family protein 0.0037 0.0129 0.0551
Mycobacterium ulcerans epoxide hydrolase EphA 0.0158 0.0753 0.5163
Brugia malayi MH2 domain containing protein 0.014 0.0658 0.1315
Schistosoma mansoni gabp alpha 0.0085 0.0375 0.075
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0052 0.0105
Entamoeba histolytica heat shock protein 90, putative 0.0092 0.0414 0.4181
Leishmania major heat shock protein 83-1 0.0092 0.0414 0.0793
Brugia malayi RNA recognition motif domain containing protein 0.0074 0.0321 0.0641
Plasmodium falciparum pyruvate kinase 2 0.002 0.0042 0.0242
Mycobacterium ulcerans short chain dehydrogenase 0.0291 0.1439 1
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0062 0.0259 0.2531
Leishmania major heat shock protein 83-1 0.0092 0.0414 0.0793
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0062 0.0259 0.048
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0052 0.0066
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0038 0.0137 0.0273
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0028 0.0082 0.0433
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0091 0.0758
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0199 0.0964 0.4734
Trichomonas vaginalis sensor histidine kinase, putative 0.0062 0.0259 0.2531
Schistosoma mansoni hypothetical protein 0.0048 0.0184 0.0369
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0034 0.0068
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0082 0.0164
Loa Loa (eye worm) hypothetical protein 0.0028 0.0082 0.0082
Schistosoma mansoni ets-related 0.0257 0.1263 0.2525
Brugia malayi heat shock protein 90 0.0092 0.0414 0.0828
Echinococcus granulosus Niemann Pick C1 protein 0.0164 0.0787 0.1572
Schistosoma mansoni chromobox protein 0.0067 0.0286 0.0572
Trypanosoma brucei heat shock protein, putative 0.0092 0.0414 0.0793
Brugia malayi Niemann-Pick C1 protein precursor 0.0115 0.0532 0.1064
Echinococcus multilocularis protein patched 0.0049 0.0194 0.0387
Trichomonas vaginalis DNA topoisomerase II, putative 0.0062 0.0259 0.2531
Brugia malayi hypothetical protein 0.0143 0.0677 0.1353
Echinococcus granulosus expressed conserved protein 0.0108 0.0496 0.0992
Schistosoma mansoni pyruvate kinase 0.0039 0.014 0.028
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.004 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0093 0.0147
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0091 0.0359
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.017 0.034
Trypanosoma cruzi heat shock protein 90, putative 0.0092 0.0414 0.0793
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.017 0.034
Brugia malayi beta-lactamase family protein 0.0037 0.0129 0.0258
Brugia malayi Phosphoglycerate kinase 0.0199 0.0964 0.1927
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0034 0.003
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0062 0.0259 0.2261
Onchocerca volvulus Huntingtin homolog 0.0143 0.0677 0.0677
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0093 0.0147
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0129 0.1163
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0129 0.0258
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0249 0.0461
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0151 0.1397
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0249 0.0461
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.006 0.0246 0.0455
Plasmodium falciparum DNA topoisomerase 2 0.0062 0.0259 0.2531
Loa Loa (eye worm) hypothetical protein 0.0038 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0002
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0021 0.0002
Echinococcus granulosus mitogen activated protein kinase 0.006 0.0246 0.0492
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.006 0.0246 0.0455
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0052 0.035
Trichomonas vaginalis heat shock protein, putative 0.003 0.0095 0.0801
Plasmodium vivax DNA topoisomerase II, putative 0.0062 0.0259 0.2531
Schistosoma mansoni hypothetical protein 0.0048 0.0184 0.0369
Trypanosoma brucei pyruvate kinase 1 0.0039 0.014 0.0242
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0034 0.0113 0.0225
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0129 0.0221
Giardia lamblia Heat shock protein HSP 90-alpha 0.0092 0.0414 0.4037
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0129 0.0258
Trichomonas vaginalis endoplasmin, putative 0.0078 0.0339 0.338
Echinococcus multilocularis ETS transcription factor Elf 2 0.0012 0.0002 0.0005
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0034 0.003
Schistosoma mansoni endoplasmin 0.0092 0.0414 0.0828
Plasmodium vivax pyruvate kinase, putative 0.0039 0.014 0.1277
Brugia malayi Cytochrome P450 family protein 0.0016 0.0021 0.0041
Echinococcus granulosus biogenic amine 5HT receptor 0.0154 0.0733 0.1465
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.017 0.034
Loa Loa (eye worm) hypothetical protein 0.0028 0.0082 0.0082
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0016 0.0019 0.0039
Brugia malayi Probable DNA topoisomerase II 0.0062 0.0259 0.0517
Echinococcus multilocularis neuropeptide receptor A26 0.0545 0.2746 0.5488
Schistosoma mansoni pyruvate kinase 0.0039 0.014 0.028
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0062 0.0259 0.2531
Brugia malayi Cytochrome P450 family protein 0.0016 0.0021 0.0041
Loa Loa (eye worm) hypothetical protein 0.0049 0.0194 0.0194
Schistosoma mansoni patched 1 0.0049 0.0194 0.0387
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0249 0.0461
Echinococcus multilocularis GPCR, family 2 0.0018 0.0034 0.0068
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0134 0.121
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0239 0.0479
Echinococcus multilocularis protein dispatched 1 0.0056 0.023 0.0459
Leishmania major heat shock protein 83-1 0.0092 0.0414 0.0793
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0236 0.1154 0.7969
Echinococcus granulosus heat shock protein 90 0.0092 0.0414 0.0828
Plasmodium vivax pyruvate kinase 2, putative 0.002 0.0042 0.0242
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0249 0.0461
Leishmania major heat shock protein 83-1 0.0092 0.0414 0.0793
Loa Loa (eye worm) hypothetical protein 0.0034 0.0113 0.0113
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0129 0.1163
Schistosoma mansoni ets 0.0012 0.0002 0.0005
Mycobacterium ulcerans putative regultory protein 0.0062 0.0259 0.1678
Schistosoma mansoni endoplasmin 0.0092 0.0414 0.0828
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0151 0.1397
Echinococcus multilocularis pyruvate kinase 0.0031 0.0098 0.0195
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0049 0.0194 0.0194
Loa Loa (eye worm) CYP4Cod1 0.0016 0.0021 0.002
Giardia lamblia Kinase, CMGC MAPK 0.006 0.0246 0.221
Loa Loa (eye worm) acetyltransferase 0.014 0.0661 0.0662
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0034 0.0069
Schistosoma mansoni pyruvate kinase 0.002 0.0042 0.0084
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0129 0.0676
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0151 0.0302
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0062 0.0259 0.1198
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0129 0.0676
Brugia malayi Hsp90 protein 0.0016 0.0019 0.0039
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0062 0.0259 0.2261
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0239 0.024
Schistosoma mansoni hypothetical protein 0.0048 0.0184 0.0369
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0052 0.0066
Echinococcus granulosus protein C ets 2 0.0012 0.0002 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0077 0.0608
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0034 0.0113 0.0225
Trypanosoma brucei phosphoglycerate kinase, putative 0.0073 0.0315 0.0594
Brugia malayi hydrolase, alpha/beta fold family protein 0.0971 0.4945 0.9883
Entamoeba histolytica acyl-coA synthetase, putative 0.0028 0.0082 0.0662
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0129 0.0767
Brugia malayi Endoplasmin precursor 0.0092 0.0414 0.0828
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0052 0.0053
Echinococcus granulosus geminin 0.0164 0.0783 0.1564
Schistosoma mansoni pyruvate dehydrogenase 0.0983 0.5003 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.006 0.0246 0.0247
Mycobacterium ulcerans DNA polymerase IV 0.006 0.0249 0.1612
Echinococcus granulosus chromobox protein 1 0.0067 0.0286 0.0572
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0246 0.0492
Leishmania major heat shock protein 83-1 0.0092 0.0414 0.0793
Echinococcus multilocularis ewsr:fli fusion protein type 0.0012 0.0002 0.0005
Plasmodium falciparum phosphoglycerate kinase 0.0199 0.0964 1
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0249 0.0461
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0129 0.0221
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0129 0.0767
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0091 0.0758
Onchocerca volvulus Huntingtin homolog 0.0143 0.0677 0.0677
Onchocerca volvulus 0.0037 0.0129 0.0129
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0034 0.0113 0.0225
Leishmania major hypothetical protein, conserved 0.0029 0.0091 0.0144
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0249 0.0461
Plasmodium vivax endoplasmin, putative 0.0092 0.0414 0.4181
Mycobacterium leprae Probable pyruvate kinase PykA 0.0039 0.014 0.0659
Trypanosoma cruzi heat shock protein 85, putative 0.0092 0.0414 0.0793
Echinococcus multilocularis sterol regulatory element binding protein 0.0049 0.0194 0.0387
Echinococcus granulosus neuropeptide receptor A26 0.0545 0.2746 0.5488
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.0003 0.0005
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.017 0.034
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0052 0.0225
Mycobacterium ulcerans hypothetical protein 0.0028 0.0082 0.0433
Echinococcus multilocularis chromobox protein 1 0.0067 0.0286 0.0572
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0034 0.0069
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0052 0.0129
Mycobacterium ulcerans DNA polymerase IV 0.006 0.0249 0.1612
Trypanosoma brucei heat shock protein, putative 0.0092 0.0414 0.0793
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.017 0.034
Loa Loa (eye worm) endoplasmin 0.0092 0.0414 0.0415
Mycobacterium tuberculosis Conserved protein 0.0037 0.0129 0.0676
Echinococcus granulosus heat shock protein 0.0092 0.0414 0.0828
Loa Loa (eye worm) heat shock protein 90 0.0092 0.0414 0.0415
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0082 0.0662
Echinococcus multilocularis Niemann Pick C1 protein 0.0115 0.0532 0.1063
Loa Loa (eye worm) hydrolase 0.1948 0.9978 1
Trypanosoma brucei heat shock protein 90, putative 0.0092 0.0414 0.0793
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0062 0.0259 0.1678
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0062 0.0259 0.0517
Schistosoma mansoni phosphoglycerate kinase 0.0199 0.0964 0.1927
Trypanosoma brucei heat shock protein, putative 0.0092 0.0414 0.0793
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0082 0.0433
Brugia malayi isocitrate dehydrogenase 0.0018 0.0034 0.0069
Chlamydia trachomatis pyruvate kinase 0.0039 0.014 0.1026
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0091 0.0144
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0129 0.0676
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0052 0.0066
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0062 0.0259 0.1678
Leishmania major pyruvate kinase 0.0039 0.014 0.0242
Schistosoma mansoni pyruvate dehydrogenase 0.0921 0.4684 0.9362
Brugia malayi beta-lactamase 0.0037 0.0129 0.0258
Echinococcus granulosus dna polymerase eta 0.0034 0.0113 0.0225
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0046 0.0082
Schistosoma mansoni phosphoglycerate kinase 0.0199 0.0964 0.1927
Loa Loa (eye worm) hypothetical protein 0.0199 0.0964 0.0966
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.004 0.0041
Echinococcus granulosus pyruvate kinase 0.002 0.0042 0.0084
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0321 0.0641
Loa Loa (eye worm) hypothetical protein 0.0154 0.0733 0.0735
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0082 0.0662
Schistosoma mansoni pyruvate dehydrogenase 0.0921 0.4684 0.9362
Loa Loa (eye worm) hypothetical protein 0.0029 0.0091 0.0091
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0021 0.0002
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0034 0.0075
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0074 0.0321 0.0321
Leishmania major mitochondrial DNA topoisomerase II 0.0062 0.0259 0.048
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.0661 0.1321
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0199 0.0964 1
Echinococcus multilocularis neuropeptide s receptor 0.0545 0.2746 0.5488
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0403 0.2015 1
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.014 0.014
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0028 0.0082 0.0339
Loa Loa (eye worm) pyruvate kinase 0.0039 0.014 0.014
Brugia malayi TAR-binding protein 0.0074 0.0321 0.0641
Echinococcus granulosus mitogen activated protein kinase 3 0.006 0.0246 0.0492
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0085 0.0375 0.0376
Leishmania major heat shock protein 83-1 0.0092 0.0414 0.0793
Toxoplasma gondii DNA topoisomerase 2, putative 0.0062 0.0259 0.1198
Trichomonas vaginalis pyruvate kinase, putative 0.0039 0.014 0.1277
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0199 0.0964 0.4734
Entamoeba histolytica deoxycytidyl transferase, putative 0.0034 0.0113 0.0989
Plasmodium falciparum endoplasmin, putative 0.0078 0.0339 0.338
Trypanosoma brucei heat shock protein, putative 0.0092 0.0414 0.0793
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0034 0.0158
Echinococcus multilocularis pyruvate kinase 0.0039 0.014 0.028
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0948 0.4823 0.9639
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0082 0.0433
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0249 0.0461
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0341 0.1696 0.84
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0062 0.0259 0.048
Echinococcus multilocularis chromobox protein 1 0.0067 0.0286 0.0572
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0034 0.0068
Leishmania major DNA polymerase kappa, putative 0.004 0.0147 0.0255
Loa Loa (eye worm) heterochromatin protein 1 0.0067 0.0286 0.0287
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0249 0.0461
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0129 0.0676
Echinococcus multilocularis GA binding protein alpha chain 0.0085 0.0375 0.075
Schistosoma mansoni ets-related 0.0012 0.0002 0.0005
Trypanosoma cruzi heat shock protein 85, putative 0.003 0.0095 0.0152
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0151 0.0661
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0046 0.028
Entamoeba histolytica phosphoglycerate kinase, putative 0.0199 0.0964 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0134 0.121
Schistosoma mansoni hypothetical protein 0.0018 0.0034 0.0068
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0321 0.0641
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.0147 0.0255
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0062 0.0259 0.048
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0062 0.0259 0.0517
Echinococcus multilocularis pyruvate kinase 0.0039 0.014 0.028
Leishmania major heat shock protein 83-1 0.0092 0.0414 0.0793
Trypanosoma cruzi pyruvate kinase 2, putative 0.0039 0.014 0.0242
Trypanosoma brucei heat shock protein, putative 0.0092 0.0414 0.0793
Loa Loa (eye worm) hypothetical protein 0.0021 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.0164 0.0783 0.1564
Echinococcus multilocularis ets variant gene 4 0.0012 0.0002 0.0005
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0034 0.0113 0.0113
Echinococcus granulosus pyruvate kinase 0.002 0.0042 0.0084
Loa Loa (eye worm) pyruvate kinase 0.0039 0.014 0.014
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0286 0.2822
Echinococcus multilocularis heat shock protein 90 0.003 0.0095 0.019
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0129 0.0221
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.006 0.0249 0.2432
Leishmania major DNA topoisomerase ii 0.0062 0.0259 0.048
Loa Loa (eye worm) hypothetical protein 0.0062 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0034
Plasmodium vivax hypothetical protein, conserved 0.0062 0.0259 0.2531
Brugia malayi Heterochromatin protein 1 0.0067 0.0286 0.0572
Trichomonas vaginalis heat shock protein, putative 0.0092 0.0414 0.4181
Loa Loa (eye worm) beta-lactamase 0.0037 0.0129 0.013
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0151 0.1397
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0129 0.0258
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0062 0.0259 0.0517
Echinococcus multilocularis heat shock protein 0.0092 0.0414 0.0828
Loa Loa (eye worm) fli-1 protein 0.0257 0.1263 0.1266
Brugia malayi Phosphoglycerate kinase 0.0073 0.0315 0.063

Activities

Activity type Activity value Assay description Source Reference
Change (functional) = -36 % Effect of the compound on the synthesis rate of 5 HTP accumulation at the dose of 100 micromol/kg in the rat ventral limbic brain region ChEMBL. 8459396
Change (functional) = -24 % Effect of the compound on the synthesis rate of dopamine (DOPA) accumulation at the dose of 100 micromol/kg in the rat ventral limbic brain region ChEMBL. 8459396
Change (functional) = 17 % Effect of the compound on the synthesis rate of 5 HTP accumulation at the dose of 10 micromol/kg in the rat ventral limbic brain region ChEMBL. 8459396
Change (functional) = 35 % Effect of the compound on the synthesis rate of dopamine (DOPA) accumulation at the dose of 10 microM/kg in the rat ventral limbic brain region ChEMBL. 8459396
Ki (binding) > 1000 nM In vivo binding affinity towards [3H]-8-OH-DPAT-labeled 5-hydroxytryptamine 1A receptor sites in bovine hippocampus. ChEMBL. 8459396
Ki (binding) > 1000 nM In vivo binding affinity towards [3H]-8-OH-DPAT-labeled 5-hydroxytryptamine 1A receptor sites in bovine hippocampus. ChEMBL. 8459396

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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