Detailed information for compound 276550

Basic information

Technical information
  • TDR Targets ID: 276550
  • Name: 8-(4-acetyl-3-hydroxy-2-propylphenoxy)octanoi c acid
  • MW: 336.423 | Formula: C19H28O5
  • H donors: 2 H acceptors: 4 LogP: 4.76 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCc1c(OCCCCCCCC(=O)O)ccc(c1O)C(=O)C
  • InChi: 1S/C19H28O5/c1-3-9-16-17(12-11-15(14(2)20)19(16)23)24-13-8-6-4-5-7-10-18(21)22/h11-12,23H,3-10,13H2,1-2H3,(H,21,22)
  • InChiKey: FGHCFIGUBUNXBE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 8-(4-acetyl-3-hydroxy-2-propyl-phenoxy)octanoic acid
  • 8-(4-ethanoyl-3-hydroxy-2-propyl-phenoxy)octanoic acid
  • 8-(4-acetyl-3-hydroxy-2-propyl-phenoxy)caprylic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi MAP kinase sur-1 0.0051 0.0011 0.0018
Schistosoma mansoni hypothetical protein 0.1184 0.2487 0.3321
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0134 0.0191 0.0189
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0568 0.114 0.1138
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0133 0.019 0.0187
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.0037 0.0065
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0134 0.0191 0.0191
Leishmania major heat shock protein 83-1 0.0141 0.0207 0.0377
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0077 0.0067 0.0067
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0141 0.0207 1
Toxoplasma gondii aldose reductase, putative 0.0134 0.0191 0.0883
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0058 0.0025 0.0042
Onchocerca volvulus 0.0269 0.0487 0.0871
Entamoeba histolytica hypothetical protein 0.0077 0.0067 0.1129
Loa Loa (eye worm) hypothetical protein 0.0063 0.0037 0.0064
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0141 0.0207 0.0664
Brugia malayi CXXC zinc finger family protein 0.0052 0.0013 0.0022
Echinococcus granulosus glutamate receptor NMDA 0.26 0.5579 0.5578
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0049 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0141 0.0207 0.0369
Brugia malayi ecdysone receptor 0.0063 0.0037 0.0064
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0134 0.0191 0.342
Echinococcus multilocularis ecdysone induced protein 78C 0.0133 0.019 0.019
Schistosoma mansoni hypothetical protein 0.1034 0.2158 0.2881
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0058 0.0025 0.0044
Loa Loa (eye worm) hypothetical protein 0.0133 0.019 0.0338
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.1456 0.308 1
Echinococcus granulosus dnaJ subfamily B 0.0741 0.1519 0.1516
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0133 0.019 0.0246
Loa Loa (eye worm) hypothetical protein 0.0291 0.0536 0.0957
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.007 0.0053 0.005
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0417 0.0811 0.0811
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0141 0.0207 0.0204
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.2531 0.5427 0.5427
Entamoeba histolytica hypothetical protein 0.0077 0.0067 0.1129
Loa Loa (eye worm) hypothetical protein 0.0082 0.0079 0.014
Entamoeba histolytica heat shock protein 90, putative 0.0141 0.0207 0.3711
Schistosoma mansoni coup transcription factor 0.0133 0.019 0.0246
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0134 0.0191 0.0189
Schistosoma mansoni protein kinase 0.0291 0.0536 0.0709
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0133 0.019 0.0338
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0165 0.0261 0.0261
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0133 0.019 0.0338
Leishmania major heat shock protein 83-1 0.0141 0.0207 0.0377
Brugia malayi Kringle domain containing protein 0.0544 0.1089 0.1947
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0141 0.0207 0.0377
Leishmania major hypothetical protein, conserved 0.0544 0.1089 0.2002
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0016 0.0013
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0063 0.0037 0.0037
Brugia malayi exodeoxyribonuclease III family protein 0.0058 0.0025 0.0044
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0544 0.1089 0.6471
Loa Loa (eye worm) hypothetical protein 0.0269 0.0487 0.0871
Echinococcus multilocularis nmda type glutamate receptor 0.4624 1 1
Schistosoma mansoni hypothetical protein 0.0544 0.1089 0.145
Schistosoma mansoni hypothetical protein 0.0568 0.114 0.1519
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0577 0.116 0.116
Schistosoma mansoni nuclear receptor 0.0063 0.0037 0.0041
Leishmania major aldo-keto reductase-like protein 0.0134 0.0191 0.0348
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0251 0.0448 0.8145
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0165 0.0261 0.0258
Loa Loa (eye worm) hypothetical protein 0.0055 0.0019 0.0033
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0291 0.0536 0.0536
Echinococcus multilocularis serotonin transporter 0.0147 0.0222 0.0222
Trypanosoma cruzi hypothetical protein, conserved 0.0544 0.1089 0.2002
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0885 0.1832 0.3372
Brugia malayi Niemann-Pick C1 protein precursor 0.0104 0.0127 0.0226
Schistosoma mansoni ap endonuclease 0.0058 0.0025 0.0026
Onchocerca volvulus 0.0064 0.0039 0.0069
Schistosoma mansoni tar DNA-binding protein 0.019 0.0315 0.0414
Trypanosoma cruzi DNA topoisomerase II, putative 0.0141 0.0207 0.0377
Trypanosoma brucei heat shock protein, putative 0.0141 0.0207 0.0377
Onchocerca volvulus 0.0134 0.0191 0.0341
Schistosoma mansoni transcription factor LCR-F1 0.0077 0.0067 0.0082
Echinococcus multilocularis microtubule associated protein 2 0.0729 0.1492 0.1492
Onchocerca volvulus 0.0134 0.0191 0.0341
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0141 0.0207 0.0595
Trichomonas vaginalis aldo-keto reductase, putative 0.0134 0.0191 0.342
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0141 0.0207 0.0369
Brugia malayi Glutamate receptor 1 precursor 0.0577 0.116 0.2075
Loa Loa (eye worm) hypothetical protein 0.0147 0.0222 0.0395
Trypanosoma cruzi heat shock protein 90, putative 0.0141 0.0207 0.0377
Schistosoma mansoni cercarial elastase (S01 family) 0.0269 0.0487 0.0645
Trypanosoma cruzi Heat shock protein 83, putative 0.0141 0.0207 0.0377
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0095 0.0106 0.0191
Entamoeba histolytica aldose reductase, putative 0.0134 0.0191 0.342
Brugia malayi mbt repeat family protein 0.0053 0.0016 0.0026
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0134 0.0191 0.0341
Onchocerca volvulus 0.0053 0.0016 0.0026
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.2604 0.5588 0.7473
Echinococcus granulosus atrial natriuretic peptide receptor 0.0291 0.0536 0.0533
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0134 0.0191 0.0191
Echinococcus multilocularis aldo keto reductase 0.0134 0.0191 0.0191
Loa Loa (eye worm) TK/ROR protein kinase 0.0544 0.1089 0.1947
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0141 0.0207 0.0377
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0134 0.0191 0.0348
Brugia malayi SEA domain containing protein 0.0064 0.0039 0.0069
Brugia malayi nuclear receptor RXR 0.007 0.0053 0.0093
Echinococcus granulosus tm gpcr rhodopsin 0.0833 0.172 0.1717
Schistosoma mansoni glutamate receptor NMDA 0.3468 0.7476 1
Loa Loa (eye worm) integrin beta-2 0.0186 0.0307 0.0548
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0133 0.019 0.0338
Echinococcus multilocularis receptor type guanylyl cyclase 0.0291 0.0536 0.0536
Leishmania major heat shock protein 83-1 0.0141 0.0207 0.0377
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0052 0.0013 0.0009
Entamoeba histolytica hypothetical protein 0.0077 0.0067 0.1129
Loa Loa (eye worm) hypothetical protein 0.007 0.0053 0.0093
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0134 0.0191 0.342
Toxoplasma gondii heat shock protein 90, putative 0.0141 0.0207 0.0957
Echinococcus multilocularis muscleblind protein 0.0164 0.0259 0.0259
Brugia malayi nuclear receptor NHR-67 0.0063 0.0037 0.0064
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0269 0.0487 0.0645
Schistosoma mansoni cercarial elastase (S01 family) 0.0269 0.0487 0.0645
Loa Loa (eye worm) hypothetical protein 0.0133 0.019 0.0338
Schistosoma mansoni hypothetical protein 0.0269 0.0487 0.0645
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0568 0.114 0.1138
Brugia malayi metabotropic glutamate receptor type 2 0.0291 0.0536 0.0957
Echinococcus granulosus heat shock protein 0.0141 0.0207 0.0204
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0141 0.0207 0.0595
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0137 0.0198 0.0195
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.007 0.0053 0.0063
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0063 0.0037 0.0037
Schistosoma mansoni cercarial elastase (S01 family) 0.0269 0.0487 0.0645
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0417 0.0811 0.1077
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0291 0.0536 0.0536
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.1456 0.308 1
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0141 0.0207 0.0664
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0133 0.019 0.0338
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0011 0.0006
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0141 0.0207 0.0595
Echinococcus granulosus geminin 0.1034 0.2158 0.2156
Schistosoma mansoni hypothetical protein 0.0063 0.0037 0.0042
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0133 0.019 0.0187
Onchocerca volvulus 0.0064 0.0039 0.0069
Echinococcus granulosus Tolloid protein 1 0.0052 0.0013 0.001
Echinococcus granulosus histone acetyltransferase MYST2 0.006 0.0032 0.0029
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0007 0.0002
Echinococcus multilocularis dihydrofolate reductase 0.0236 0.0416 0.0416
Giardia lamblia Pms1-like protein 0.0141 0.0207 0.6949
Loa Loa (eye worm) hypothetical protein 0.0291 0.0536 0.0957
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0141 0.0207 0.0664
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0291 0.0536 0.0957
Onchocerca volvulus 0.0269 0.0487 0.0871
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0141 0.0207 0.0369
Brugia malayi Latrophilin receptor protein 2 0.0063 0.0037 0.0065
Echinococcus multilocularis NMDA receptor 0.0568 0.114 0.114
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0133 0.019 0.0338
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0816 0.1681 1
Brugia malayi latrophilin 2 splice variant baaae 0.0136 0.0197 0.0351
Brugia malayi hypothetical protein 0.0077 0.0067 0.0119
Schistosoma mansoni tyrosine kinase 0.0291 0.0536 0.0709
Schistosoma mansoni tar DNA-binding protein 0.019 0.0315 0.0414
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0141 0.0207 0.0664
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0359 0.0685 0.1224
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0236 0.0416 0.1342
Loa Loa (eye worm) hypothetical protein 0.0291 0.0536 0.0957
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0134 0.0191 0.0191
Schistosoma mansoni hypothetical protein 0.1034 0.2158 0.2881
Echinococcus multilocularis tissue type plasminogen activator 0.0544 0.1089 0.1089
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0011 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0133 0.019 0.0338
Trichomonas vaginalis DNA topoisomerase II, putative 0.0141 0.0207 0.3711
Schistosoma mansoni pyruvate dehydrogenase 0.239 0.512 0.6846
Loa Loa (eye worm) serotonin transporter b 0.0147 0.0222 0.0395
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0134 0.0191 0.0189
Loa Loa (eye worm) glutathione reductase 0.0047 0.0003 0.0003
Onchocerca volvulus 0.2604 0.5588 1
Loa Loa (eye worm) hypothetical protein 0.0133 0.019 0.0338
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0141 0.0207 0.1218
Schistosoma mansoni cercarial elastase (S01 family) 0.0269 0.0487 0.0645
Echinococcus granulosus receptor type guanylyl cyclase 0.0291 0.0536 0.0533
Echinococcus granulosus metabotropic glutamate receptor 5 0.0291 0.0536 0.0533
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0063 0.0037 0.0064
Trypanosoma brucei protein kinase, putative 0.0051 0.0011 0.0015
Loa Loa (eye worm) hypothetical protein 0.0147 0.0222 0.0395
Loa Loa (eye worm) endoplasmin 0.0141 0.0207 0.0369
Schistosoma mansoni metabotropic glutamate receptor 0.0291 0.0536 0.0709
Brugia malayi hypothetical protein 0.007 0.0053 0.0093
Mycobacterium ulcerans oxidoreductase 0.0134 0.0191 0.0543
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0095 0.0106 0.1855
Onchocerca volvulus 0.0134 0.0191 0.0341
Loa Loa (eye worm) hypothetical protein 0.2604 0.5588 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0011 0.0008
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0134 0.0191 0.0191
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.0135 0.0429
Loa Loa (eye worm) hypothetical protein 0.0063 0.0037 0.0064
Echinococcus granulosus ecdysone induced protein 78C 0.0133 0.019 0.0187
Mycobacterium ulcerans hypothetical protein 0.0269 0.0487 0.1513
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0291 0.0536 0.0957
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0868 0.1796 0.1796
Brugia malayi thymidylate synthase 0.0579 0.1165 0.2084
Schistosoma mansoni pyruvate dehydrogenase 0.2531 0.5427 0.7258
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0025 0.0135
Brugia malayi kinase, mitochondrial precursor 0.2531 0.5427 0.9712
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0141 0.0207 0.0377
Echinococcus multilocularis cpg binding protein 0.0055 0.002 0.002
Trypanosoma brucei DNA topoisomerase ii 0.0141 0.0207 0.0377
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0134 0.0191 0.0798
Loa Loa (eye worm) hypothetical protein 0.0291 0.0536 0.0957
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0011 0.0088
Loa Loa (eye worm) MBCTL1 0.006 0.0032 0.0055
Plasmodium vivax DNA topoisomerase II, putative 0.0141 0.0207 0.1218
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0579 0.1165 0.1552
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0816 0.1681 0.7854
Loa Loa (eye worm) hypothetical protein 0.0359 0.0685 0.1224
Loa Loa (eye worm) hypothetical protein 0.0291 0.0536 0.0957
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0063 0.0037 0.0037
Giardia lamblia Aldose reductase 0.0134 0.0191 0.6391
Loa Loa (eye worm) hypothetical protein 0.0291 0.0536 0.0957
Schistosoma mansoni zinc finger protein 0.0063 0.0037 0.0041
Brugia malayi hypothetical protein 0.0063 0.0037 0.0064
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0297 0.0548 0.1005
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0133 0.019 0.0246
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.2024 0.432 0.432
Schistosoma mansoni cercarial elastase (S01 family) 0.0269 0.0487 0.0645
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0269 0.0487 0.0487
Brugia malayi Glutamate receptor 2 precursor 0.0577 0.116 0.2075
Trypanosoma brucei aldo-keto reductase, putative 0.0134 0.0191 0.0348
Loa Loa (eye worm) hypothetical protein 0.0141 0.0207 0.0369
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0063 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.007 0.0053 0.0093
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0134 0.0191 0.0348
Loa Loa (eye worm) oxidoreductase 0.0134 0.0191 0.0341
Loa Loa (eye worm) hypothetical protein 0.0063 0.0037 0.0064
Schistosoma mansoni thyroid hormone receptor 0.1317 0.2777 0.371
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0133 0.019 0.0338
Trypanosoma brucei heat shock protein, putative 0.0141 0.0207 0.0377
Brugia malayi Thioredoxin reductase 0.0047 0.0003 0.0003
Echinococcus multilocularis aldo keto reductase 0.0134 0.0191 0.0191
Echinococcus multilocularis neuropeptide s receptor 0.0274 0.0497 0.0497
Schistosoma mansoni integrin beta subunit 0.011 0.014 0.0179
Onchocerca volvulus 0.0052 0.0013 0.0022
Toxoplasma gondii histone lysine methyltransferase SET1 0.0099 0.0115 0.0525
Loa Loa (eye worm) hypothetical protein 0.0269 0.0487 0.0871
Loa Loa (eye worm) hypothetical protein 0.0136 0.0197 0.0351
Echinococcus multilocularis nuclear receptor nhr 48 0.0063 0.0037 0.0037
Mycobacterium ulcerans two component sensor kinase MprB 0.0141 0.0207 0.0595
Leishmania major heat shock protein 83-1 0.0141 0.0207 0.0377
Trichomonas vaginalis aldo/keto reductase, putative 0.0134 0.0191 0.342
Plasmodium vivax heat shock protein 86, putative 0.0141 0.0207 0.1218
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0221 0.0382 0.0379
Brugia malayi RNA binding protein 0.019 0.0315 0.0563
Loa Loa (eye worm) hypothetical protein 0.0133 0.019 0.0338
Brugia malayi glutathione reductase 0.0047 0.0003 0.0003
Echinococcus granulosus tissue type plasminogen activator 0.0544 0.1089 0.1086
Loa Loa (eye worm) RGC/RGC protein kinase 0.0291 0.0536 0.0957
Loa Loa (eye worm) hypothetical protein 0.0063 0.0037 0.0064
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0291 0.0536 0.0957
Loa Loa (eye worm) hypothetical protein 0.0164 0.0259 0.0462
Onchocerca volvulus 0.0134 0.0191 0.0341
Echinococcus multilocularis FTZ F1 alpha 0.0133 0.019 0.019
Schistosoma mansoni hypothetical protein 0.0063 0.0037 0.0042
Loa Loa (eye worm) hypothetical protein 0.0291 0.0536 0.0957
Echinococcus granulosus Niemann Pick C1 protein 0.0149 0.0224 0.0222
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.2531 0.5427 0.5426
Onchocerca volvulus 0.0579 0.1165 0.2084
Schistosoma mansoni aldo-keto reductase 0.0134 0.0191 0.0248
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0579 0.1165 0.3778
Loa Loa (eye worm) TAR-binding protein 0.019 0.0315 0.0563
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0141 0.0207 0.0595
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0134 0.0191 0.0191
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0058 0.0025 0.0519
Brugia malayi Trypsin family protein 0.0269 0.0487 0.0871
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0236 0.0416 0.2918
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0141 0.0207 0.0377
Loa Loa (eye worm) nuclear hormone receptor 0.0063 0.0037 0.0064
Trypanosoma cruzi aldo-keto reductase 0.0134 0.0191 0.0348
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0816 0.1681 0.3094
Brugia malayi Muscle positioning protein 4 0.0098 0.0114 0.0203
Echinococcus multilocularis glycoprotein Antigen 5 0.0269 0.0487 0.0487
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0885 0.1832 0.3372
Trichomonas vaginalis aldo-keto reductase, putative 0.0134 0.0191 0.342
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0049 0.0006 0.0009
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0141 0.0207 0.0664
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0133 0.019 0.0187
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.0198 0.0257
Echinococcus multilocularis enteropeptidase 0.0269 0.0487 0.0487
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0833 0.172 0.172
Leishmania major heat shock protein 83-1 0.0141 0.0207 0.0377
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0133 0.019 0.0338
Echinococcus multilocularis Niemann Pick C1 protein 0.0104 0.0127 0.0127
Chlamydia trachomatis dihydrofolate reductase 0.0236 0.0416 0.0726
Schistosoma mansoni pyruvate dehydrogenase 0.239 0.512 0.6846
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0141 0.0207 0.3711
Brugia malayi ecdysteroid receptor 0.0133 0.019 0.0338
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0134 0.0191 0.0191
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0269 0.0487 0.0645
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.0135 0.0429
Echinococcus granulosus glutamate receptor 2 0.0868 0.1796 0.1794
Loa Loa (eye worm) nuclear receptor NHR-67 0.0063 0.0037 0.0064
Mycobacterium leprae Probable two-component sensor kinase 0.0141 0.0207 0.0948
Onchocerca volvulus 0.0133 0.019 0.0338
Brugia malayi Calcitonin receptor-like protein seb-1 0.0199 0.0335 0.0598
Onchocerca volvulus 0.0147 0.0222 0.0395
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0133 0.019 0.0338
Loa Loa (eye worm) hypothetical protein 0.0063 0.0037 0.0065
Loa Loa (eye worm) hypothetical protein 0.0063 0.0038 0.0067
Plasmodium falciparum ataxin-2 like protein, putative 0.0082 0.0079 0.0454
Plasmodium falciparum DNA gyrase subunit B 0.0141 0.0207 0.1218
Schistosoma mansoni retinoic acid receptor RXR 0.0133 0.019 0.0246
Brugia malayi Endoplasmin precursor 0.0141 0.0207 0.0369
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.2531 0.5427 0.5427
Echinococcus granulosus aldo keto reductase 0.0134 0.0191 0.0189
Schistosoma mansoni cpg binding protein 0.0055 0.002 0.0019
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.006 0.0032 0.0032
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0141 0.0207 0.0957
Onchocerca volvulus 0.0134 0.0191 0.0341
Onchocerca volvulus 0.0049 0.0007 0.0012
Brugia malayi Nuclear hormone receptor E75 0.0063 0.0037 0.0064
Mycobacterium tuberculosis Possible two component sensor kinase 0.0141 0.0207 0.0664
Onchocerca volvulus 0.0544 0.1089 0.1947
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0297 0.0548 1
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.1456 0.308 1
Brugia malayi Steroid receptor seven-up type 2 0.0133 0.019 0.0338
Schistosoma mansoni sodium/chloride dependent transporter 0.0147 0.0222 0.0289
Loa Loa (eye worm) phosphatidylinositol 3 0.0371 0.071 0.127
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0137 0.0198 0.0195
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0141 0.0207 0.0948
Loa Loa (eye worm) hypothetical protein 0.0269 0.0487 0.0871
Schistosoma mansoni glutamate receptor kainate 0.0577 0.116 0.1545
Toxoplasma gondii LsmAD domain-containing protein 0.0082 0.0079 0.0356
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0141 0.0207 0.0664
Schistosoma mansoni mixed-lineage leukemia protein mll 0.011 0.0141 0.018
Trichomonas vaginalis aldo-keto reductase, putative 0.0134 0.0191 0.342
Schistosoma mansoni cpg binding protein 0.0052 0.0013 0.001
Leishmania major heat shock protein 83-1 0.0141 0.0207 0.0377
Schistosoma mansoni steroid hormone receptor ad4bp 0.0133 0.019 0.0246
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0058 0.0025 0.0359
Treponema pallidum sodium- and chloride- dependent transporter 0.0147 0.0222 0.0643
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0579 0.1165 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0133 0.019 0.0187
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0221 0.0382 0.0382
Trypanosoma brucei heat shock protein, putative 0.0141 0.0207 0.0377
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0141 0.0207 0.3711
Echinococcus granulosus GPCR family 2 0.0063 0.0037 0.0035
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.0161 0.0514
Trypanosoma brucei heat shock protein, putative 0.0141 0.0207 0.0377
Onchocerca volvulus 0.0064 0.0039 0.0069
Trypanosoma cruzi heat shock protein 90, putative 0.0141 0.0207 0.0377
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0137 0.0198 0.0353
Mycobacterium tuberculosis Probable two component sensor kinase 0.0141 0.0207 0.0664
Echinococcus granulosus integrin beta 2 0.0138 0.0201 0.0199
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0049 0.0006 0.0015
Onchocerca volvulus 0.0291 0.0536 0.0957
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0141 0.0207 0.0207
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0417 0.0811 0.0808
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0095 0.0106 0.1855
Schistosoma mansoni glutamate receptor kainate 0.0577 0.116 0.1545
Onchocerca volvulus 0.0063 0.0037 0.0064
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0133 0.019 0.0187
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0133 0.019 0.019
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0141 0.0207 0.3711
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0003 0.0003
Schistosoma mansoni aldo-keto reductase 0.0134 0.0191 0.0248
Echinococcus multilocularis dnaJ subfamily B 0.0741 0.1519 0.1519
Trypanosoma cruzi DNA topoisomerase II, putative 0.0141 0.0207 0.0377
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.0135 0.0429
Schistosoma mansoni cercarial elastase (S01 family) 0.0269 0.0487 0.0645
Entamoeba histolytica DNA topoisomerase II, putative 0.0141 0.0207 0.3711
Echinococcus multilocularis transmembrane protease serine 3 0.0269 0.0487 0.0487
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0133 0.019 0.0338
Loa Loa (eye worm) hypothetical protein 0.2531 0.5427 0.9712
Leishmania major heat shock protein 83-1 0.0141 0.0207 0.0377
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0016 0.0013
Leishmania major heat shock protein 83-1 0.0141 0.0207 0.0377
Echinococcus granulosus muscleblind protein 0.0164 0.0259 0.0256
Loa Loa (eye worm) hypothetical protein 0.0133 0.019 0.0338
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0052 0.0012 0.002
Schistosoma mansoni endoplasmin 0.0141 0.0207 0.0269
Leishmania major heat shock protein 83-1 0.0141 0.0207 0.0377
Echinococcus multilocularis tumor protein p63 0.0337 0.0636 0.0636
Trichomonas vaginalis receptor histidine kinase, putative 0.0141 0.0207 0.3711
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0058 0.0025 0.0042
Loa Loa (eye worm) hypothetical protein 0.0052 0.0013 0.0021
Echinococcus multilocularis glutamate receptor 2 0.0868 0.1796 0.1796
Mycobacterium ulcerans putative regultory protein 0.0141 0.0207 0.0595
Loa Loa (eye worm) hypothetical protein 0.0133 0.019 0.0338
Brugia malayi Nuclear hormone receptor-like 1 0.0687 0.1401 0.2506
Brugia malayi hypothetical protein 0.0269 0.0487 0.0871
Loa Loa (eye worm) heat shock protein 90 0.0141 0.0207 0.0369
Echinococcus multilocularis aldo keto reductase 0.0134 0.0191 0.0191
Trichomonas vaginalis sensor histidine kinase, putative 0.0141 0.0207 0.3711
Echinococcus granulosus tar DNA binding protein 0.019 0.0315 0.0313
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0141 0.0207 0.0948
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.018 0.0293 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0063 0.0037 0.0041
Brugia malayi Muscleblind-like protein 0.0164 0.0259 0.0462
Brugia malayi conserved hypotetical protein 0.0063 0.0037 0.0064
Echinococcus granulosus Mastin 0.0269 0.0487 0.0485
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0011 0.0037
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0011 0.0015
Echinococcus multilocularis heat shock protein 90 0.0141 0.0207 0.0207
Trypanosoma cruzi PAB1-binding protein , putative 0.0082 0.0079 0.014
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.0135 0.0429
Brugia malayi TAR-binding protein 0.019 0.0315 0.0563
Schistosoma mansoni tar DNA-binding protein 0.019 0.0315 0.0414
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0133 0.019 0.0338
Brugia malayi Nuclear hormone receptor E75 0.0063 0.0037 0.0064
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0269 0.0487 0.0645
Mycobacterium tuberculosis Probable oxidoreductase 0.0134 0.0191 0.0613
Trypanosoma brucei prostaglandin f synthase 0.0134 0.0191 0.0348
Onchocerca volvulus Bile acid receptor homolog 0.0133 0.019 0.0338
Onchocerca volvulus 0.0134 0.0191 0.0341
Leishmania major heat shock protein 83-1 0.0141 0.0207 0.0377
Echinococcus granulosus neuropeptide receptor A26 0.0274 0.0497 0.0495
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.1456 0.308 1
Toxoplasma gondii kringle domain-containing protein 0.0544 0.1089 0.5083
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0816 0.1681 0.3094
Loa Loa (eye worm) hypothetical protein 0.0063 0.0037 0.0064
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0291 0.0536 0.0957
Leishmania major heat shock protein 83-1 0.0141 0.0207 0.0377
Loa Loa (eye worm) DR-78 0.0063 0.0037 0.0064
Echinococcus granulosus thymidylate synthase 0.0579 0.1165 0.1163
Brugia malayi Protein kinase domain containing protein 0.0544 0.1089 0.1947
Echinococcus multilocularis Mastin 0.0269 0.0487 0.0487
Echinococcus granulosus microtubule associated protein 2 0.0729 0.1492 0.149
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0058 0.0025 0.0042
Echinococcus granulosus glutamate NMDA receptor subunit 0.0577 0.116 0.1158
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0057 0.0024 0.0482
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.0037 0.0037
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0063 0.0037 0.0064
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0133 0.019 0.0246
Trichomonas vaginalis heat shock protein, putative 0.0141 0.0207 0.3711
Loa Loa (eye worm) oxidoreductase 0.0134 0.0191 0.0341
Loa Loa (eye worm) hypothetical protein 0.0134 0.0191 0.0341
Echinococcus granulosus heat shock protein 90 0.0141 0.0207 0.0204
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0049 0.0006 0.0006
Schistosoma mansoni dihydrofolate reductase 0.0236 0.0416 0.0549
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0049 0.0006 0.0015
Trypanosoma brucei Heat shock protein 83, putative 0.0141 0.0207 0.0377
Loa Loa (eye worm) mbt repeat family protein 0.0053 0.0016 0.0026
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0297 0.0548 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0082 0.0079 0.0454
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0141 0.0207 0.0664
Schistosoma mansoni tyrosine kinase 0.0291 0.0536 0.0709
Echinococcus granulosus hypothetical protein 0.0134 0.0191 0.0189
Brugia malayi Trypsin-like protease protein 5 0.0269 0.0487 0.0871
Leishmania major prostaglandin f synthase, putative 0.0134 0.0191 0.0348
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0011 0.0015
Schistosoma mansoni microtubule-associated protein tau 0.0729 0.1492 0.199
Schistosoma mansoni heat shock protein 0.0141 0.0207 0.0269
Trypanosoma brucei heat shock protein, putative 0.0141 0.0207 0.0377
Loa Loa (eye worm) hypothetical protein 0.0269 0.0487 0.0871
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0133 0.019 0.0338
Trypanosoma cruzi heat shock protein 85, putative 0.0141 0.0207 0.0377
Leishmania major hypothetical protein, conserved 0.0141 0.0207 0.0377
Mycobacterium ulcerans two component regulator - sensor kinase 0.0141 0.0207 0.0595
Leishmania major heat shock protein 83-1 0.0141 0.0207 0.0377
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0137 0.0198 0.0198
Onchocerca volvulus Protein ultraspiracle homolog 0.0133 0.019 0.0338
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0133 0.019 0.0338
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0095 0.0106 0.0135
Loa Loa (eye worm) hypothetical protein 0.0211 0.036 0.0643
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0134 0.0191 0.0191
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.0161 0.0514
Onchocerca volvulus 0.0063 0.0037 0.0064
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0141 0.0207 0.0664
Brugia malayi hypothetical protein 0.0291 0.0536 0.0957
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.1025 0.214 1
Echinococcus multilocularis glutamate receptor 2 0.0577 0.116 0.116
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0226 0.0394 0.7156
Brugia malayi Nuclear hormone receptor-like 1 0.0687 0.1401 0.2506
Echinococcus granulosus cpg binding protein 0.0055 0.002 0.0017
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0133 0.019 0.019
Onchocerca volvulus 0.0269 0.0487 0.0871
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0297 0.0548 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0297 0.0548 0.0979
Brugia malayi nuclear hormone receptor 0.0063 0.0037 0.0064
Brugia malayi hypothetical protein 0.0082 0.0079 0.014
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0049 0.0006 0.0006
Onchocerca volvulus 0.2335 0.5 0.8948
Brugia malayi tailless protein 0.0063 0.0037 0.0064
Entamoeba histolytica heat shock protein 90, putative 0.0141 0.0207 0.3711
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0095 0.0106 0.0189
Trypanosoma brucei heat shock protein, putative 0.0141 0.0207 0.0377
Brugia malayi photoreceptor-specific nuclear receptor 0.0133 0.019 0.0338
Echinococcus granulosus serotonin transporter 0.0147 0.0222 0.0219
Loa Loa (eye worm) oxidoreductase 0.0134 0.0191 0.0341
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0199 0.0335 0.0598
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0053 0.0016 0.0013
Brugia malayi Trypsin family protein 0.0269 0.0487 0.0871
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0053 0.0016 0.0026
Echinococcus granulosus thyroid hormone receptor alpha 0.0063 0.0037 0.0034
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.006 0.0032 0.0055
Brugia malayi Dihydrofolate reductase 0.0236 0.0416 0.0742
Trichomonas vaginalis endoplasmin, putative 0.0141 0.0207 0.3711
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0141 0.0207 0.0957
Echinococcus multilocularis muscleblind protein 1 0.0164 0.0259 0.0259
Brugia malayi RNA recognition motif domain containing protein 0.019 0.0315 0.0563
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0049 0.0006 0.0019
Trichomonas vaginalis aldo-keto reductase, putative 0.0134 0.0191 0.342
Giardia lamblia Heat shock protein HSP 90-alpha 0.0141 0.0207 0.6949
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0133 0.019 0.0338
Loa Loa (eye worm) hypothetical protein 0.0199 0.0335 0.0598
Trypanosoma cruzi extracellular receptor, putative 0.0291 0.0536 0.0982
Schistosoma mansoni hypothetical protein 0.0269 0.0487 0.0645
Brugia malayi Metabotropic glutamate receptor precursor. 0.0291 0.0536 0.0957
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0134 0.0191 0.0341
Echinococcus granulosus aldo keto reductase 0.0134 0.0191 0.0189
Trypanosoma brucei heat shock protein, putative 0.0141 0.0207 0.0377
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0868 0.1796 0.1794
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.1184 0.2487 0.2487
Loa Loa (eye worm) hypothetical protein 0.0291 0.0536 0.0957
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0141 0.0207 0.0595
Schistosoma mansoni glutamate receptor kainate 0.0577 0.116 0.1545
Schistosoma mansoni thyroid hormone receptor 0.1317 0.2777 0.371
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0291 0.0536 0.0957
Schistosoma mansoni myelin transcription factor 1 myt1 0.006 0.0032 0.0034
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0025 0.0359
Brugia malayi N-terminal motif family protein 0.0095 0.0108 0.0192
Toxoplasma gondii heat shock protein HSP90 0.0141 0.0207 0.0957
Loa Loa (eye worm) dihydrofolate reductase 0.0236 0.0416 0.0742
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0269 0.0487 0.0645
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0063 0.0037 0.0034
Echinococcus granulosus FTZ F1 alpha 0.0133 0.019 0.0187
Trypanosoma brucei C-8 sterol isomerase, putative 0.0359 0.0685 0.1257
Giardia lamblia Aldose reductase 0.0134 0.0191 0.6391
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0084 0.0082 0.0147
Loa Loa (eye worm) hypothetical protein 0.0132 0.0187 0.0333
Onchocerca volvulus 0.0098 0.0114 0.0203
Schistosoma mansoni cpg binding protein 0.0055 0.002 0.0019
Brugia malayi Trypsin family protein 0.2604 0.5588 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.006 0.0032 0.0032
Echinococcus multilocularis Niemann Pick C1 protein 0.0149 0.0224 0.0224
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0269 0.0487 0.0871
Echinococcus multilocularis expressed conserved protein 0.0098 0.0113 0.0113
Trichomonas vaginalis aldo-keto reductase, putative 0.0134 0.0191 0.342
Schistosoma mansoni hypothetical protein 0.0136 0.0197 0.0256
Loa Loa (eye worm) hypothetical protein 0.0049 0.0007 0.0012
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0269 0.0487 0.0485
Brugia malayi Probable DNA topoisomerase II 0.0141 0.0207 0.0369
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0816 0.1681 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0134 0.0191 0.0189
Onchocerca volvulus Arrow homolog 0.0052 0.0012 0.002
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0052 0.0013 0.0021
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0141 0.0207 0.0595
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0297 0.0548 0.1005
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0134 0.0191 0.0341
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.019 0.0315 0.0563
Echinococcus multilocularis heat shock protein 0.0141 0.0207 0.0207
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0885 0.1832 0.3372
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0133 0.019 0.0338
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0133 0.019 0.0338
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0134 0.0191 0.0189
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0133 0.019 0.0187
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.0198 0.0257
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0568 0.114 0.1138
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0133 0.019 0.0338
Trichomonas vaginalis conserved hypothetical protein 0.0276 0.0502 0.9144
Loa Loa (eye worm) hypothetical protein 0.0165 0.0261 0.0465
Echinococcus multilocularis thyroid hormone receptor alpha 0.1317 0.2777 0.2777
Leishmania major heat shock protein 83-1 0.0141 0.0207 0.0377
Loa Loa (eye worm) hypothetical protein 0.0133 0.019 0.0338
Onchocerca volvulus 0.0291 0.0536 0.0957
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0868 0.1796 0.1796
Schistosoma mansoni nuclear hormone receptor 0.0133 0.019 0.0246
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.006 0.0032 0.0029
Trypanosoma cruzi heat shock protein 85, putative 0.0141 0.0207 0.0377
Schistosoma mansoni metabotropic glutamate receptor 0.0291 0.0536 0.0709
Brugia malayi mbt repeat family protein 0.0053 0.0016 0.0026
Loa Loa (eye worm) steroid hormone receptor 0.0133 0.019 0.0338
Echinococcus multilocularis glutamate receptor NMDA 0.26 0.5579 0.5579
Loa Loa (eye worm) hypothetical protein 0.0291 0.0536 0.0957
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0011 0.0088
Loa Loa (eye worm) hypothetical protein 0.0063 0.0037 0.0064
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0095 0.0108 0.0192
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.1184 0.2487 0.2485
Loa Loa (eye worm) glutamate receptor 1 0.0577 0.116 0.2075
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0134 0.0191 0.0191
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0134 0.0191 0.0189
Schistosoma mansoni endoplasmin 0.0141 0.0207 0.0269
Schistosoma mansoni ATP-binding cassette transporter 0.0577 0.116 0.1545
Loa Loa (eye worm) phosphatidylinositol 3 0.0084 0.0082 0.0146
Brugia malayi hypothetical protein 0.0063 0.0037 0.0064
Onchocerca volvulus 0.0269 0.0487 0.0871
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0077 0.0067 0.0064
Brugia malayi nuclear hormone receptor family member nhr-6 0.0063 0.0037 0.0064
Brugia malayi dihydrofolate reductase family protein 0.0236 0.0416 0.0742
Echinococcus granulosus tyrosine kinase 0.0291 0.0536 0.0533
Brugia malayi nuclear receptor RXR 0.0063 0.0037 0.0064
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0281 0.0513 0.0679
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0133 0.019 0.0246
Echinococcus granulosus Nuclear hormone receptor HR96 0.0063 0.0037 0.0034
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0141 0.0207 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0687 0.1401 0.2506
Schistosoma mansoni nuclear hormone receptor 0.0063 0.0037 0.0041
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0104 0.0127 0.2231
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0063 0.0037 0.0034
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0025 0.0135
Trichomonas vaginalis aldo-keto reductase, putative 0.0134 0.0191 0.342
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0105 0.0129 0.0165
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0141 0.0207 0.3711
Loa Loa (eye worm) hypothetical protein 0.0184 0.0301 0.0537
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0133 0.019 0.0246
Brugia malayi Receptor family ligand binding region containing protein 0.0291 0.0536 0.0957
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0058 0.0025 0.0042
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0141 0.0207 0.0595
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0141 0.0207 0.0377
Loa Loa (eye worm) oxidoreductase 0.0134 0.0191 0.0341
Schistosoma mansoni hypothetical protein 0.0077 0.0067 0.0082
Loa Loa (eye worm) hypothetical protein 0.068 0.1385 0.2477
Brugia malayi Guanylyl cyclase protein 23 0.0291 0.0536 0.0957
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0049 0.0006 0.0003
Echinococcus multilocularis protein dispatched 1 0.0051 0.0011 0.0011
Schistosoma mansoni nuclear receptor 0.0063 0.0037 0.0041
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.2628 0.5639 0.7542
Plasmodium vivax endoplasmin, putative 0.0141 0.0207 0.1218
Schistosoma mansoni glutamate receptor AMPA 0.0577 0.116 0.1545
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0141 0.0207 0.0664
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.006 0.0032 0.0055
Echinococcus granulosus nuclear receptor nhr 48 0.0063 0.0037 0.0034
Echinococcus multilocularis neuropeptide receptor A26 0.0274 0.0497 0.0497
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0095 0.0106 0.1855
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0291 0.0536 0.0536
Mycobacterium leprae Probable two component sensor kinase MprB 0.0141 0.0207 0.0948
Loa Loa (eye worm) hypothetical protein 0.0063 0.0037 0.0064
Echinococcus multilocularis biogenic amine (5HT) receptor 0.3123 0.672 0.672
Brugia malayi orphan nuclear receptor NR2E1 0.0063 0.0037 0.0064
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0276 0.0502 0.092
Toxoplasma gondii exonuclease III APE 0.0058 0.0025 0.0106
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0011 0.0088
Loa Loa (eye worm) RNA binding protein 0.019 0.0315 0.0563
Leishmania major hypothetical protein, conserved 0.0082 0.0079 0.014
Loa Loa (eye worm) CXXC zinc finger family protein 0.0052 0.0013 0.0022
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0147 0.0222 0.0395
Leishmania major extracellular receptor, putative 0.0291 0.0536 0.0982
Schistosoma mansoni nuclear receptor nhr-48 0.0063 0.0037 0.0041
Brugia malayi hypothetical protein 0.0276 0.0502 0.0896
Loa Loa (eye worm) RGC/RGC protein kinase 0.0291 0.0536 0.0957
Brugia malayi hypothetical protein 0.007 0.0053 0.0093
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.0161 0.0512
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0141 0.0207 0.0369
Trypanosoma brucei heat shock protein, putative 0.0141 0.0207 0.0377
Plasmodium vivax DNA gyrase subunit B, putative 0.0141 0.0207 0.1218
Echinococcus granulosus glycoprotein Antigen 5 0.0269 0.0487 0.0485
Brugia malayi Integrin beta pat-3 precursor 0.0186 0.0307 0.0548
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0134 0.0191 0.0189
Trichomonas vaginalis aldo-keto reductase, putative 0.0134 0.0191 0.342
Loa Loa (eye worm) oxidoreductase 0.0134 0.0191 0.0341
Loa Loa (eye worm) RGC/RGC protein kinase 0.0291 0.0536 0.0957
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.0037 0.0035
Echinococcus multilocularis polycomb protein SCMH1 0.0053 0.0016 0.0016
Echinococcus granulosus enteropeptidase 0.0269 0.0487 0.0485
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0095 0.0106 0.0191
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0133 0.019 0.0187
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0141 0.0207 0.3711
Onchocerca volvulus 0.0269 0.0487 0.0871
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0269 0.0487 0.0485
Trypanosoma brucei heat shock protein 90, putative 0.0141 0.0207 0.0377
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0106 0.013 0.0167
Schistosoma mansoni DNA topoisomerase II 0.0141 0.0207 0.0269
Loa Loa (eye worm) hypothetical protein 0.0064 0.0039 0.0069
Schistosoma mansoni glutamate receptor AMPA 0.0577 0.116 0.1545
Loa Loa (eye worm) hypothetical protein 0.0063 0.0037 0.0064
Leishmania major heat shock protein 83-1 0.0141 0.0207 0.0377
Schistosoma mansoni hypothetical protein 0.0063 0.0037 0.0042
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0058 0.0025 0.0023
Echinococcus multilocularis Zinc finger, PHD finger 0.0049 0.0006 0.0006
Brugia malayi hypothetical protein 0.0053 0.0015 0.0026
Brugia malayi heat shock protein 90 0.0141 0.0207 0.0369
Loa Loa (eye worm) hypothetical protein 0.0063 0.0037 0.0064
Echinococcus multilocularis aldo keto reductase 0.0134 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0164 0.0259 0.0462
Plasmodium vivax hypothetical protein, conserved 0.0141 0.0207 0.1218
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0134 0.0191 0.0191
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0137 0.0198 0.0198
Brugia malayi Receptor family ligand binding region containing protein 0.0291 0.0536 0.0957
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0568 0.114 0.114
Loa Loa (eye worm) trypsin family protein 0.0269 0.0487 0.0871
Mycobacterium ulcerans thymidylate synthase 0.0579 0.1165 0.3731
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0011 0.0015
Echinococcus granulosus dihydrofolate reductase 0.0236 0.0416 0.0413
Trichomonas vaginalis receptor histidine kinase, putative 0.0141 0.0207 0.3711
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0011 0.0088
Echinococcus granulosus SAM and MBT domain containing protein 0.0053 0.0016 0.0013
Mycobacterium tuberculosis Conserved protein 0.0141 0.0207 0.0664
Schistosoma mansoni biogenic amine (5HT) receptor 0.3123 0.672 0.8989
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0133 0.019 0.019
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0003 0.0003
Echinococcus granulosus neuropeptide s receptor 0.0274 0.0497 0.0495
Loa Loa (eye worm) solute carrier family 6 member 4 0.0147 0.0222 0.0395
Loa Loa (eye worm) hypothetical protein 0.0269 0.0487 0.0871
Echinococcus multilocularis survival motor neuron protein 1 0.0211 0.036 0.036
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.1456 0.308 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0134 0.0191 0.0341
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.0037 0.0035
Trypanosoma brucei PAB1-binding protein , putative 0.0082 0.0079 0.014
Leishmania major C-8 sterol isomerase-like protein 0.0359 0.0685 0.1257
Plasmodium falciparum DNA topoisomerase 2 0.0141 0.0207 0.1218
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0134 0.0191 0.0189
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0063 0.0037 0.0037
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0058 0.0025 0.0025
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0063 0.0037 0.0064
Schistosoma mansoni hypothetical protein 0.0064 0.0039 0.0045
Loa Loa (eye worm) hypothetical protein 0.0544 0.1089 0.1947
Echinococcus granulosus survival motor neuron protein 1 0.0211 0.036 0.0357
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0049 0.0006 0.0003
Echinococcus multilocularis integrin beta 2 0.0138 0.0201 0.0201
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0165 0.0261 0.0465
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0568 0.114 0.114
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0134 0.0191 0.0189
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0049 0.0006 0.0006
Chlamydia trachomatis glutamine binding protein 0.1456 0.308 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0137 0.0198 0.0353
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0816 0.1681 0.3094
Trypanosoma brucei heat shock protein 90, putative 0.0141 0.0207 0.0377
Mycobacterium tuberculosis Hypothetical protein 0.0276 0.0502 0.1621
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0133 0.019 0.0338
Trypanosoma cruzi PAB1-binding protein , putative 0.0082 0.0079 0.014
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0141 0.0207 0.0369
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0269 0.0487 0.0645
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0063 0.0037 0.0041
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0868 0.1796 0.1794
Brugia malayi nuclear hormone receptor family member odr-7 0.0063 0.0037 0.0064
Trichomonas vaginalis aldo-keto reductase, putative 0.0134 0.0191 0.342
Loa Loa (eye worm) hypothetical protein 0.0053 0.0016 0.0026
Echinococcus granulosus biogenic amine 5HT receptor 0.3123 0.672 0.6719
Trypanosoma brucei developmentally regulated phosphoprotein 0.2531 0.5427 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0868 0.1796 0.1794
Schistosoma mansoni cercarial elastase (S01 family) 0.0269 0.0487 0.0645
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.0037 0.0065
Leishmania major heat shock protein 83-1 0.0141 0.0207 0.0377
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0049 0.0006 0.0019
Echinococcus granulosus Niemann Pick C1 protein 0.0104 0.0127 0.0124
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.007 0.0053 0.0053
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0297 0.0548 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0269 0.0487 0.0645
Loa Loa (eye worm) glutamate receptor 2 0.0577 0.116 0.2075
Leishmania major phosphatidylinositol 3-kinase, putative 0.0049 0.0006 0.0006
Mycobacterium ulcerans DNA gyrase subunit B 0.0141 0.0207 0.0595
Schistosoma mansoni cercarial elastase (S01 family) 0.0269 0.0487 0.0645
Trichomonas vaginalis aldo-keto reductase, putative 0.0134 0.0191 0.342
Entamoeba histolytica hypothetical protein 0.0291 0.0536 0.9771
Brugia malayi steroid hormone receptor 0.0133 0.019 0.0338
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0868 0.1796 0.1796
Trichomonas vaginalis aldo-keto reductase, putative 0.0134 0.0191 0.342
Leishmania major DNA topoisomerase ii 0.0141 0.0207 0.0377
Loa Loa (eye worm) hypothetical protein 0.0147 0.0222 0.0395
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0063 0.0037 0.0064
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0141 0.0207 0.0595
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0269 0.0487 0.0487
Trichomonas vaginalis aldo-keto reductase, putative 0.0134 0.0191 0.342
Echinococcus multilocularis aldehyde reductase 0.0095 0.0107 0.0107
Loa Loa (eye worm) TOPoisomerase family member 0.0141 0.0207 0.0369
Loa Loa (eye worm) hypothetical protein 0.007 0.0053 0.0093
Entamoeba histolytica aldose reductase, putative 0.0134 0.0191 0.342
Schistosoma mansoni heat shock protein 0.0141 0.0207 0.0269
Trypanosoma cruzi heat shock protein 85, putative 0.0141 0.0207 0.0377
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.0037 0.0037
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0133 0.019 0.019
Loa Loa (eye worm) hypothetical protein 0.0098 0.0114 0.0203
Leishmania major mitochondrial DNA topoisomerase II 0.0141 0.0207 0.0377
Echinococcus granulosus nmda type glutamate receptor 0.2891 0.6215 0.6214
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.0161 0.0514
Loa Loa (eye worm) hypothetical protein 0.0052 0.0012 0.002
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0011 0.0011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.0198 0.0257
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0133 0.019 0.0338
Echinococcus granulosus transmembrane protease serine 3 0.0269 0.0487 0.0485
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0885 0.1832 0.8561
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0011 0.0015
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0147 0.0222 0.0289
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0134 0.0191 0.342
Echinococcus multilocularis thymidylate synthase 0.0579 0.1165 0.1165
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0868 0.1796 0.1796
Loa Loa (eye worm) hypothetical protein 0.0063 0.0037 0.0064
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0816 0.1682 0.1682
Toxoplasma gondii DNA topoisomerase 2, putative 0.0141 0.0207 0.0957
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0011 0.0018
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0226 0.0394 0.7156
Echinococcus granulosus aldehyde reductase 0.0095 0.0107 0.0104
Schistosoma mansoni hypothetical protein 0.0334 0.063 0.0836
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0133 0.019 0.019
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0133 0.019 0.0246
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0286 0.0524 0.9554
Mycobacterium tuberculosis Probable reductase 0.0108 0.0135 0.0429
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0095 0.0106 0.1855
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0133 0.019 0.019
Leishmania major heat shock protein 83-1 0.0141 0.0207 0.0377
Brugia malayi Nuclear hormone receptor-like 1 0.075 0.1538 0.2751
Schistosoma mansoni retinoid-x-receptor (RXR) 0.007 0.0053 0.0063
Trichomonas vaginalis aldo/keto reductase, putative 0.0134 0.0191 0.342
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0868 0.1796 0.1794
Brugia malayi nuclear hormone receptor 0.0133 0.019 0.0338
Schistosoma mansoni tar DNA-binding protein 0.019 0.0315 0.0414
Loa Loa (eye worm) thymidylate synthase 0.0579 0.1165 0.2084
Brugia malayi nuclear receptor NHR-88 0.0063 0.0037 0.0064
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0141 0.0207 0.0595
Loa Loa (eye worm) hypothetical protein 0.0104 0.0127 0.0226
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0141 0.0207 0.0664
Leishmania major developmentally regulated phosphoprotein-like protein 0.2531 0.5427 1
Echinococcus multilocularis GPCR, family 2 0.0063 0.0037 0.0037
Schistosoma mansoni cercarial elastase (S01 family) 0.0269 0.0487 0.0645
Schistosoma mansoni hypothetical protein 0.0063 0.0037 0.0042
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.2531 0.5427 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0053 0.0016 0.0016
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0011 0.0015
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.0135 0.0264
Plasmodium falciparum heat shock protein 90 0.0141 0.0207 0.1218
Echinococcus granulosus expressed conserved protein 0.0098 0.0113 0.011
Echinococcus granulosus Nuclear hormone receptor HR96 0.0063 0.0037 0.0034
Schistosoma mansoni tar DNA-binding protein 0.019 0.0315 0.0414
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0134 0.0191 0.0191
Schistosoma mansoni memapsin-2 (A01 family) 0.0419 0.0815 0.1083
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0359 0.0685 0.1257
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.012 0.0162 0.0289
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0025 0.0359
Trypanosoma cruzi aldo/keto reductase, putative 0.0134 0.0191 0.0348
Loa Loa (eye worm) hypothetical protein 0.0133 0.019 0.0338
Echinococcus multilocularis glutamate receptor 2 0.03 0.0555 0.0555
Schistosoma mansoni pol-related 0.0134 0.0191 0.0248
Echinococcus multilocularis nmda type glutamate receptor 0.2891 0.6215 0.6215
Onchocerca volvulus 0.0064 0.0039 0.0069
Loa Loa (eye worm) hypothetical protein 0.007 0.0053 0.0093
Echinococcus multilocularis tyrosine kinase 0.0291 0.0536 0.0536
Loa Loa (eye worm) hypothetical protein 0.2604 0.5588 1
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0141 0.0207 0.0369
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0011 0.0008
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0236 0.0416 0.1278
Schistosoma mansoni hypothetical protein 0.0741 0.1519 0.2025
Plasmodium vivax ataxin-2 like protein, putative 0.0082 0.0079 0.0454
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0011 0.0015
Entamoeba histolytica aldose reductase, putative 0.0134 0.0191 0.342
Brugia malayi nuclear receptor NHR-88 0.0133 0.019 0.0338
Leishmania major heat shock protein 83-1 0.0141 0.0207 0.0377
Loa Loa (eye worm) glutamate receptor 0.0291 0.0536 0.0957
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0133 0.019 0.0338
Loa Loa (eye worm) hypothetical protein 0.007 0.0053 0.0093
Entamoeba histolytica hypothetical protein 0.0251 0.0448 0.8145
Echinococcus multilocularis Tolloid protein 1 0.0052 0.0013 0.0013
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.0135 0.0429
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0052 0.0012 0.002
Loa Loa (eye worm) hypothetical protein 0.0095 0.0108 0.0192
Echinococcus granulosus aldo keto reductase 0.0134 0.0191 0.0189
Trichomonas vaginalis aldo/keto reductase, putative 0.0134 0.0191 0.342
Trichomonas vaginalis aldo-keto reductase, putative 0.0134 0.0191 0.342
Schistosoma mansoni ap endonuclease 0.0058 0.0025 0.0026
Echinococcus granulosus tumor protein p63 0.0337 0.0636 0.0634
Echinococcus granulosus metabotropic glutamate receptor 2 0.0291 0.0536 0.0533
Trichomonas vaginalis heat shock protein, putative 0.0141 0.0207 0.3711
Brugia malayi Trypsin family protein 0.0269 0.0487 0.0871
Loa Loa (eye worm) hypothetical protein 0.0063 0.0037 0.0064
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0049 0.0006 0.0009
Loa Loa (eye worm) norepinephrine transporter 0.0147 0.0222 0.0395
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0141 0.0207 0.0664
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0199 0.0335 0.0598
Echinococcus granulosus glutamate receptor 2 0.03 0.0555 0.0553
Echinococcus granulosus glutamate receptor subunit protein glur 0.0568 0.114 0.1138
Entamoeba histolytica hypothetical protein 0.0077 0.0067 0.1129
Schistosoma mansoni nuclear hormone receptor 0.0063 0.0037 0.0041
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0134 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0063 0.0037 0.0064
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0141 0.0207 0.0595
Schistosoma mansoni RAR-like nuclear receptor 0.0133 0.019 0.0246
Echinococcus multilocularis geminin 0.1034 0.2158 0.2158
Schistosoma mansoni cercarial elastase (S01 family) 0.0269 0.0487 0.0645
Plasmodium falciparum cysteine repeat modular protein 1 0.0544 0.1089 0.6471
Echinococcus granulosus polycomb protein SCMH1 0.0053 0.0016 0.0013
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0141 0.0207 0.0377
Schistosoma mansoni glutamate receptor NMDA 0.0577 0.116 0.1545
Brugia malayi hypothetical protein 0.0211 0.036 0.0643
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0058 0.0025 0.0074
Loa Loa (eye worm) DOMON domain-containing protein 0.0064 0.0039 0.0069
Echinococcus multilocularis tar DNA binding protein 0.019 0.0315 0.0315
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0095 0.0106 0.1855
Plasmodium falciparum endoplasmin, putative 0.0141 0.0207 0.1218
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0141 0.0207 1
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0568 0.114 0.114
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0119 0.016 0.2844
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0133 0.019 0.0338
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0049 0.0006 0.0006

Activities

Activity type Activity value Assay description Source Reference
-Log IC50 (functional) = 6.1 Negative logarithm of compound concentration that reduced an LTD4-induced contraction of guinea pig ileum by 50% ChEMBL. 3031291
pKB (functional) Inhibition of LTD4-induced contraction of guinea pig ileum; No data. ChEMBL. 3031291
pKB (functional) 0 Inhibition of LTD4-induced contraction of guinea pig ileum; No data. ChEMBL. 3031291

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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