Detailed information for compound 279469

Basic information

Technical information
  • TDR Targets ID: 279469
  • Name: ethyl 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyri din-5-yl)benzoate
  • MW: 270.326 | Formula: C16H18N2O2
  • H donors: 0 H acceptors: 2 LogP: 2.65 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1ccc(cc1)C1CCCc2n1cnc2
  • InChi: 1S/C16H18N2O2/c1-2-20-16(19)13-8-6-12(7-9-13)15-5-3-4-14-10-17-11-18(14)15/h6-11,15H,2-5H2,1H3
  • InChiKey: LQCSQWQXNLFGKK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzoic acid ethyl ester
  • ethyl 4-(5,6,7,8-tetrahydroimidazo[5,1-f]pyridin-5-yl)benzoate
  • 4-(5,6,7,8-tetrahydroimidazo[5,1-f]pyridin-5-yl)benzoic acid ethyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis beta lactamase domain, putative 0.0017 0.0101 0.1731
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0037 0.0285 0.0266
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0285 0.0285
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0017 0.0101 0.2333
Schistosoma mansoni DNA helicase recq5 0.001 0.0045 0.0045
Mycobacterium tuberculosis Conserved hypothetical protein 0.0017 0.0101 0.012
Mycobacterium tuberculosis Conserved hypothetical protein 0.0017 0.0101 0.012
Loa Loa (eye worm) hypothetical protein 0.0037 0.0285 0.0285
Mycobacterium leprae conserved hypothetical protein 0.0017 0.0101 0.0441
Loa Loa (eye worm) hypothetical protein 0.0017 0.0101 0.0101
Mycobacterium ulcerans anthranilate phosphoribosyltransferase 0.0186 0.1602 0.2725
Loa Loa (eye worm) hypothetical protein 0.0037 0.0285 0.0285
Entamoeba histolytica metallo-beta-lactamase family protein 0.0017 0.0101 0.3538
Mycobacterium tuberculosis Conserved protein 0.0017 0.0101 0.012
Loa Loa (eye worm) hypothetical protein 0.0037 0.0285 0.0285
Giardia lamblia Protein tyrosine phosphatase 0.0037 0.0285 1
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0175 0.0141
Entamoeba histolytica metallo-beta-lactamase family protein 0.0017 0.0101 0.3538
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0285 0.0251
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0285 0.0251
Toxoplasma gondii metallo-beta-lactamase domain-containing protein 0.0017 0.0101 0.2216
Onchocerca volvulus 0.0037 0.0285 0.5966
Echinococcus multilocularis 0.0037 0.0285 0.0266
Brugia malayi Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. 0.0017 0.0101 0.0067
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0037 0.0285 0.0266
Loa Loa (eye worm) hypothetical protein 0.0037 0.0285 0.0285
Echinococcus multilocularis hypothetical protein 0.0037 0.0285 0.0266
Onchocerca volvulus 4.1 G protein, putative homolog 0.0037 0.0285 0.5966
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0037 0.0285 0.0285
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0037 0.0285 0.0266
Onchocerca volvulus 0.0037 0.0285 0.5966
Mycobacterium ulcerans hydrolase 0.0017 0.0101 0.012
Entamoeba histolytica metallo-beta-lactamase family protein 0.0017 0.0101 0.3538
Entamoeba histolytica type A flavoprotein, putative 0.0017 0.0101 0.3538
Trypanosoma cruzi glyoxalase II 0.0017 0.0101 0.3538
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0101 0.2226
Mycobacterium ulcerans beta lactamase-like protein 0.0017 0.0101 0.012
Loa Loa (eye worm) hypothetical protein 0.0037 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.0037 0.0285 0.0285
Brugia malayi Protein-tyrosine phosphatase 1 0.0037 0.0285 0.0251
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0037 0.0285 0.0285
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0037 0.0285 0.0266
Onchocerca volvulus 0.0037 0.0285 0.5966
Trichomonas vaginalis beta lactamase domain, putative 0.0017 0.0101 0.1731
Echinococcus granulosus zinc phosphodiesterase 0.0017 0.0101 0.0082
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0037 0.0285 0.0266
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0017 0.0101 0.2333
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0285 0.0251
Onchocerca volvulus 0.0037 0.0285 0.5966
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0037 0.0285 0.0285
Trichomonas vaginalis pten, drome, putative 0.0037 0.0285 0.5379
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0017 0.0101 0.3538
Mycobacterium tuberculosis Conserved protein 0.0017 0.0101 0.012
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0037 0.0285 0.0285
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0285 0.0285
Echinococcus multilocularis ETHE1 protein 0.0017 0.0101 0.0082
Schistosoma mansoni pcd6 interacting protein-related 0.0037 0.0285 0.0285
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0285 0.0251
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0037 0.0285 0.0285
Loa Loa (eye worm) metallo-beta-lactamase superfamily protein 0.0017 0.0101 0.0101
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0019 0.0019
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0037 0.0285 0.0266
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0017 0.0101 0.3538
Schistosoma mansoni zinc phosphodiesterase 0.0017 0.0101 0.0101
Leishmania major tyrosine specific protein phosphatase, putative 0.0037 0.0285 1
Onchocerca volvulus 0.0037 0.0285 0.5966
Loa Loa (eye worm) RecQ helicase 0.0025 0.0175 0.0175
Schistosoma mansoni protein tyrosine phosphatase 0.0037 0.0285 0.0285
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0013 0.00000000074633
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0285 0.0266
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0175 0.0156
Schistosoma mansoni ferritin 0.0009 0.0032 0.0032
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0285 0.0251
Mycobacterium ulcerans glyoxalase II, GloB 0.0017 0.0101 0.012
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0285 0.0285
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0285 0.0266
Echinococcus multilocularis expressed protein 0.0009 0.0032 0.0012
Schistosoma mansoni ferritin 0.0009 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0037 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.0037 0.0285 0.0285
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0037 0.0285 0.0266
Loa Loa (eye worm) DnaJ domain-containing protein 0.0064 0.0518 0.0518
Schistosoma mansoni DNA helicase recq1 0.001 0.0045 0.0045
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0285 0.0251
Plasmodium falciparum cytosolic glyoxalase II 0.0017 0.0101 0.5435
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0413 0.038
Loa Loa (eye worm) hypothetical protein 0.0016 0.0099 0.0099
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0037 0.0285 0.0266
Schistosoma mansoni hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) 0.0017 0.0101 0.0101
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0285 0.0251
Trichomonas vaginalis apoptosis inducing factor, putative 0.0017 0.0101 0.1731
Loa Loa (eye worm) hypothetical protein 0.0037 0.0285 0.0285
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0037 0.0285 0.0266
Brugia malayi hypothetical protein 0.0037 0.0285 0.0251
Schistosoma mansoni ferritin light chain 0.0009 0.0032 0.0032
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0035 0.0016
Echinococcus multilocularis cpg binding protein 0.0032 0.0233 0.0214
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0037 0.0285 0.0285
Toxoplasma gondii hydroxyacylglutathione hydrolase 0.0017 0.0101 0.2216
Entamoeba histolytica alkyl sulfatase, putative 0.0017 0.0101 0.3538
Loa Loa (eye worm) hypothetical protein 0.0037 0.0285 0.0285
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.1132 1 1
Trichomonas vaginalis A-type flavoprotein 0.0017 0.0101 0.1731
Loa Loa (eye worm) hypothetical protein 0.0037 0.0285 0.0285
Leishmania major hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative 0.0017 0.0101 0.1367
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0037 0.0285 0.0266
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0285 0.0251
Onchocerca volvulus 0.0037 0.0285 0.5966
Schistosoma mansoni hypothetical protein 0.0016 0.0099 0.0099
Mycobacterium ulcerans hydrolase 0.0017 0.0101 0.012
Loa Loa (eye worm) hypothetical protein 0.0037 0.0285 0.0285
Schistosoma mansoni cpg binding protein 0.003 0.0218 0.0218
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0017 0.0101 0.3538
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0013 0.00000000074633
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0037 0.0285 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0013 0.00000000074633
Trichomonas vaginalis beta lactamase domain, putative 0.0017 0.0101 0.1731
Mycobacterium tuberculosis Possible hydrolase 0.0017 0.0101 0.012
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0037 0.0285 0.0266
Echinococcus granulosus dnaJ subfamily B 0.0424 0.3721 0.3709
Mycobacterium tuberculosis Conserved hypothetical protein 0.0017 0.0101 0.012
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0017 0.0101 0.3538
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0037 0.0285 1
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0037 0.0285 0.0266
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0285 0.0251
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0285 0.0285
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0285 0.0251
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0072 0.2515
Loa Loa (eye worm) hypothetical protein 0.0037 0.0285 0.0285
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0101 0.1731
Loa Loa (eye worm) hydroxyacylglutathione hydrolase cytoplasmic 0.0017 0.0101 0.0101
Mycobacterium ulcerans hypothetical protein 0.0017 0.0101 0.012
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0175 0.3196
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0037 0.0285 0.0285
Mycobacterium ulcerans hypothetical protein 0.0017 0.0101 0.012
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0101 0.1731
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0099 0.008
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0037 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.0037 0.0285 0.0285
Trypanosoma brucei glyoxalase II 0.0017 0.0101 0.1367
Trypanosoma brucei metallo-beta-lactamase-like protein, putative 0.0017 0.0101 0.1367
Onchocerca volvulus 0.0037 0.0285 0.5966
Trypanosoma brucei cleavage and polyadenylation specificity factor subunit, putative 0.0017 0.0101 0.1367
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0037 0.0285 0.0285
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0037 0.0285 0.0266
Schistosoma mansoni protein tyrosine phosphatase 0.0037 0.0285 0.0285
Trichomonas vaginalis beta lactamase domain, putative 0.0017 0.0101 0.1731
Brugia malayi metallo-beta-lactamase superfamily protein 0.0017 0.0101 0.0067
Brugia malayi hypothetical protein 0.0037 0.0285 0.0251
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0045 0.0026
Brugia malayi Protein-tyrosine phosphatase 0.0037 0.0285 0.0251
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0218 0.0218
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0037 0.0285 0.0266
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0037 0.0285 1
Loa Loa (eye worm) protein tyrosine phosphatase 0.0037 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.0037 0.0285 0.0285
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0128 0.0128
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0285 0.0285
Onchocerca volvulus 0.0037 0.0285 0.5966
Schistosoma mansoni apoferritin-2 0.0009 0.0032 0.0032
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0037 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.001 0.0045 0.0045
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0285 0.0251
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0285 0.0251
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0101 0.1731
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0037 0.0285 0.0285
Mycobacterium ulcerans hypothetical protein 0.0017 0.0101 0.012
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0285 0.0251
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0037 0.0285 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0285 0.0285
Schistosoma mansoni hypothetical protein 0.0017 0.0101 0.0101
Onchocerca volvulus 0.0037 0.0285 0.5966
Loa Loa (eye worm) protein-tyrosine phosphatase 0.1132 1 1
Schistosoma mansoni ferritin 0.0009 0.0032 0.0032
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0037 0.0285 0.0285
Echinococcus granulosus ferritin 0.0009 0.0032 0.0012
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.1132 1 1
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0072 0.2515
Trypanosoma brucei hydroxyacylglutathione hydrolase, putative 0.0017 0.0101 0.1367
Echinococcus granulosus expressed protein 0.0009 0.0032 0.0012
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0037 0.0285 0.0266
Mycobacterium leprae conserved hypothetical protein 0.0017 0.0101 0.0441
Brugia malayi DnaJ domain containing protein 0.0064 0.0518 0.0485
Leishmania major cleavage and polyadenylation specificity factor, putative 0.0017 0.0101 0.1367
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0101 0.1731
Onchocerca volvulus 0.003 0.0218 0.3804
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0037 0.0285 0.0266
Mycobacterium ulcerans hypothetical protein 0.0017 0.0101 0.012
Echinococcus granulosus protein tyrosine phosphatase n9 0.0037 0.0285 0.0266
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0035 0.0035
Echinococcus granulosus cpg binding protein 0.0032 0.0233 0.0214
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0099 0.008
Schistosoma mansoni cpg binding protein 0.0032 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0125 0.1067 0.1067
Trichomonas vaginalis beta lactamase domain, putative 0.0017 0.0101 0.1731
Schistosoma mansoni hypothetical protein 0.0035 0.0267 0.0267
Onchocerca volvulus 0.0037 0.0285 0.5966
Onchocerca volvulus 0.0037 0.0285 0.5966
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0285 0.0285
Schistosoma mansoni hypothetical protein 0.0064 0.0518 0.0518
Leishmania major hypothetical protein, conserved 0.0017 0.0101 0.1367
Loa Loa (eye worm) hydroxyacylglutathione hydrolase 0.0017 0.0101 0.0101
Mycobacterium leprae Beta-lactamase-like protein 0.0017 0.0101 0.0441
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0413 0.0413
Echinococcus multilocularis ferritin 0.0009 0.0032 0.0012
Brugia malayi hypothetical protein 0.0037 0.0285 0.0251
Brugia malayi CXXC zinc finger family protein 0.003 0.0218 0.0184
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0013 0.00000000074633
Trypanosoma brucei protein tyrosine phosphatase 1 0.0037 0.0285 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0037 0.0285 0.0266
Echinococcus multilocularis tumor protein p63 0.0351 0.3066 0.3053
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0285 0.0251
Loa Loa (eye worm) hypothetical protein 0.0037 0.0285 0.0285
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0037 0.0285 0.0266
Loa Loa (eye worm) hypothetical protein 0.0017 0.0101 0.0101
Onchocerca volvulus 0.0037 0.0285 0.5966
Onchocerca volvulus 0.0037 0.0285 0.5966
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0285 0.0266
Onchocerca volvulus 0.0037 0.0285 0.5966
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0148 1
Schistosoma mansoni hypothetical protein 0.0017 0.0101 0.0101
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0037 0.0285 0.0266
Schistosoma mansoni cpg binding protein 0.0032 0.0233 0.0233
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0037 0.0285 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0103 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0045 0.0045
Brugia malayi hypothetical protein 0.0017 0.0101 0.0067
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0013 0.00000000074633
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0037 0.0285 0.0266
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0285 0.0285
Echinococcus multilocularis dnaJ subfamily C 6 0.0064 0.0518 0.05
Trypanosoma cruzi glyoxalase II 0.0017 0.0101 0.3538
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0285 0.0251
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0285 0.0285
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0099 0.0065
Loa Loa (eye worm) hypothetical protein 0.0037 0.0285 0.0285
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0285 0.0285
Mycobacterium tuberculosis Probable anthranilate phosphoribosyltransferase TrpD 0.0186 0.1602 0.2725
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0285 0.0266
Schistosoma mansoni ferritin light chain 0.0009 0.0032 0.0032
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0017 0.0101 0.0082
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0175 0.3196
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) 0.0658 0.5792 1
Brugia malayi metallo-beta-lactamase superfamily protein 0.0017 0.0101 0.0067
Loa Loa (eye worm) hypothetical protein 0.0037 0.0285 0.0285
Trypanosoma cruzi glyoxalase II 0.0017 0.0101 0.3538
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0037 0.0285 0.0266
Onchocerca volvulus 0.0037 0.0285 0.5966
Echinococcus multilocularis dnaJ subfamily B 0.0424 0.3721 0.3709
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0037 0.0285 0.0285
Treponema pallidum ribonuclease Z 0.0017 0.0101 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0285 0.0251
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0045 0.0984
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0017 0.0101 0.0082
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0045 0.0011
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0285 0.0266
Loa Loa (eye worm) hypothetical protein 0.0017 0.0101 0.0101
Schistosoma mansoni hypothetical protein 0.0016 0.0099 0.0099
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0017 0.0101 0.0082
Loa Loa (eye worm) hypothetical protein 0.0037 0.0285 0.0285
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0037 0.0285 0.0251
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0285 0.0266
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0285 0.0266
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0285 0.0251
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0013 0.00000000074633
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0017 0.0101 0.3538
Entamoeba histolytica type A flavoprotein, putative 0.0017 0.0101 0.3538
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0045 0.0984
Brugia malayi ethe1-prov protein 0.0017 0.0101 0.0067
Echinococcus multilocularis zinc phosphodiesterase 0.0017 0.0101 0.0082
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0017 0.0101 0.3538
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0515 0.0515
Onchocerca volvulus 0.0037 0.0285 0.5966
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0045 0.0026
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0285 0.0251
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0037 0.0285 0.0266
Loa Loa (eye worm) hypothetical protein 0.0035 0.0267 0.0267
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0285 0.0251
Echinococcus multilocularis GPCR, family 2 0.0016 0.0099 0.008
Loa Loa (eye worm) hypothetical protein 0.0037 0.0285 0.0285
Trichomonas vaginalis ferritin, putative 0.0009 0.0032 0.036
Loa Loa (eye worm) hypothetical protein 0.0037 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.0037 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.0037 0.0285 0.0285
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0285 0.0251
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0037 0.0285 0.0266
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0285 0.0251
Entamoeba histolytica alkyl sulfatase, putative 0.0017 0.0101 0.3538
Echinococcus granulosus ETHE1 protein 0.0017 0.0101 0.0082
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0037 0.0285 0.0285
Echinococcus multilocularis thymidine phosphorylase 0.0658 0.5792 0.5784
Mycobacterium ulcerans Zn-dependent glyoxylase 0.0017 0.0101 0.012
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0013 0.00000000074633
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0013 0.00000000074633
Onchocerca volvulus 0.0037 0.0285 0.5966
Brugia malayi hypothetical protein 0.0037 0.0285 0.0251
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0101 0.1731
Loa Loa (eye worm) hypothetical protein 0.0051 0.0409 0.0409
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0285 0.0285
Echinococcus granulosus GPCR family 2 0.0016 0.0099 0.008
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0285 0.0285
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0413 0.038
Schistosoma mansoni hypothetical protein 0.0016 0.0099 0.0099
Leishmania major metallo-beta-lactamase family-like protein 0.0017 0.0101 0.1367
Mycobacterium tuberculosis Beta lactamase like protein 0.0017 0.0101 0.012
Schistosoma mansoni ferritin 0.0009 0.0032 0.0032
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0072 0.1154
Loa Loa (eye worm) hypothetical protein 0.0037 0.0285 0.0285
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0099 0.0065
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0285 0.0266
Leishmania major metallo-beta-lactamase family protein-like protein 0.0017 0.0101 0.1367
Onchocerca volvulus 0.0037 0.0285 0.5966
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0455 1
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0037 0.0285 0.0285
Echinococcus multilocularis hydroxyacylglutathione hydrolase 0.0017 0.0101 0.0082
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0037 0.0285 0.0285
Echinococcus granulosus hydroxyacylglutathione hydrolase 0.0017 0.0101 0.0082
Brugia malayi hypothetical protein 0.0037 0.0285 0.0251
Loa Loa (eye worm) hypothetical protein 0.0052 0.0413 0.0413
Schistosoma mansoni hypothetical protein 0.0424 0.3721 0.3721
Schistosoma mansoni zinc phosphodiesterase 0.0017 0.0101 0.0101
Chlamydia trachomatis ribonuclease Z 0.0017 0.0101 0.5
Schistosoma mansoni protein tyrosine phosphatase 0.0037 0.0285 0.0285
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0037 0.0285 1
Onchocerca volvulus 0.0037 0.0285 0.5966
Echinococcus granulosus dnaJ subfamily C 6 0.0064 0.0518 0.05
Mycobacterium ulcerans hydrolase 0.0017 0.0101 0.012
Giardia lamblia Metallo-beta-lactamase superfamily protein 0.0017 0.0101 0.2333
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0045 0.0011
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0045 0.0026
Trichomonas vaginalis beta lactamase domain, putative 0.0017 0.0101 0.1731
Loa Loa (eye worm) hypothetical protein 0.0017 0.0101 0.0101
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0285 0.0285
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0099 0.0099
Schistosoma mansoni hypothetical protein 0.0016 0.0099 0.0099
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0099 0.008
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0409 0.0409
Brugia malayi Protein-tyrosine phosphatase 0.0037 0.0285 0.0251
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0267 0.0234
Mycobacterium ulcerans thymidine phosphorylase 0.0658 0.5792 1
Echinococcus granulosus bloom syndrome protein 0.0025 0.0175 0.0156
Mycobacterium leprae POSSIBLE HYDROLASE 0.0017 0.0101 0.0441
Schistosoma mansoni apoferritin-2 0.0009 0.0032 0.0032
Mycobacterium tuberculosis Possible hydrolase 0.0017 0.0101 0.012
Onchocerca volvulus 0.0051 0.0409 1
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0037 0.0285 0.0266
Echinococcus granulosus tumor protein p63 0.0351 0.3066 0.3053
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0101 0.1731
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0037 0.0285 1
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0017 0.0101 0.0082
Trichomonas vaginalis protein kinase inhibitor, putative 0.0064 0.0518 1
Onchocerca volvulus 0.0037 0.0285 0.5966
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0285 0.0251
Loa Loa (eye worm) hypothetical protein 0.0037 0.0285 0.0285
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0285 0.0285
Onchocerca volvulus 0.0037 0.0285 0.5966
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0037 0.0285 0.0266
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0099 0.008
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.1132 1 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0045 0.0026
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0017 0.0101 0.3538
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0037 0.0285 0.0251
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0037 0.0285 0.0285
Onchocerca volvulus 0.0037 0.0285 0.5966
Mycobacterium tuberculosis Conserved protein 0.0017 0.0101 0.012
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0101 0.1731
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0035 0.0016
Wolbachia endosymbiont of Brugia malayi metallo-beta-lactamase superfamily hydrolase 0.0017 0.0101 1
Onchocerca volvulus 0.0037 0.0285 0.5966
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0037 0.0285 0.0285
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0037 0.0285 0.0266
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0037 0.0285 0.0266
Entamoeba histolytica hypothetical protein, conserved 0.0017 0.0101 0.3538
Mycobacterium leprae Probable anthranilate phosphoribosyltransferase TrpD 0.0186 0.1602 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0285 0.0285
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0037 0.0285 0.0266
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0037 0.0285 0.0266
Schistosoma mansoni hypothetical protein 0.0017 0.0101 0.0101
Treponema pallidum bacterioferrin (TpF1) 0.0009 0.0032 0.3134
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0037 0.0285 0.0266
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0017 0.0101 0.3538
Echinococcus granulosus thymidine phosphorylase 0.0658 0.5792 0.5784

Activities

Activity type Activity value Assay description Source Reference
EDmin (functional) > 10 uM kg-1 Minimum inhibitory dose against ovarian estrogen synthesis ChEMBL. 1825337
IC50 (binding) = 21 nM In vitro inhibition of cytochrome P450 19A1 ChEMBL. 1825337

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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