Detailed information for compound 282208

Basic information

Technical information
  • TDR Targets ID: 282208
  • Name: 131515-14-5 (Z)-
  • MW: 319.4 | Formula: C20H21N3O
  • H donors: 1 H acceptors: 2 LogP: 3.53 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1Cn2c(O)nc3c2c(CN1C/C=C\c1ccccc1)ccc3
  • InChi: 1S/C20H21N3O/c1-15-13-23-19-17(10-5-11-18(19)21-20(23)24)14-22(15)12-6-9-16-7-3-2-4-8-16/h2-11,15H,12-14H2,1H3,(H,21,24)/b9-6-
  • InChiKey: WRLCBOFBNURUFU-TWGQIWQCSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 190779-09-0 (S-[Z])-
  • 6-(Z-1-Phenylpropen-3-yl)-4,5,6,7-tetrahydro-5-methylimidazo-[4,5,1-jk][1,4]-benzodiazepin-2(1H)-one
  • AIDS-002452
  • AIDS002452
  • Imidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one, 4,5,6,7-tetrahydro-5-methyl-6-(3-phenyl-2-propenyl)-, (Z)-(1)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0433 0.1008
Entamoeba histolytica deoxycytidyl transferase, putative 0.0053 0.0292 0.0605
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.012 0.0194
Mycobacterium tuberculosis Probable penicillin-binding membrane protein PbpB 0.0172 0.1156 0.3361
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0077 0.0465 0.1218
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0049 0.0264 0.0264
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0387 0.0375
Trypanosoma brucei unspecified product 0.0073 0.0438 0.6183
Echinococcus granulosus expressed protein 0.0033 0.0149 0.0149
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0049 0.0264 0.0252
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0025 0.0025
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0096 0.0129
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0149 0.1041
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.012 0.0194
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0324 0.0324
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0016 0.0025 0.0279
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.019 0.0426
Trypanosoma brucei DNA polymerase IV, putative 0.0073 0.0438 0.6183
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Mycobacterium ulcerans DNA polymerase IV 0.008 0.0487 0.0969
Plasmodium falciparum glutathione reductase 0.0016 0.0025 0.0274
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.005 0.082
Toxoplasma gondii ABC1 family protein 0.0072 0.0433 0.929
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0251 0.3467
Echinococcus granulosus neuropeptides capa receptor 0.0049 0.0264 0.0264
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0049 0.0264 0.1846
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.006 0.0341 0.0964
Onchocerca volvulus 0.0027 0.0102 0.0548
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.019 0.109
Schistosoma mansoni lamin 0.0027 0.0102 0.0089
Trypanosoma brucei trypanothione reductase 0.0048 0.0251 0.3467
Echinococcus multilocularis somatostatin receptor 0.0049 0.0264 0.0264
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.0387 0.0833
Loa Loa (eye worm) neuropeptide F receptor 0.0049 0.0264 0.1846
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.005 0.082
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.005 0.082
Trypanosoma cruzi DNA polymerase kappa, putative 0.008 0.0487 0.6882
Echinococcus granulosus neuropeptide FF receptor 2 0.0049 0.0264 0.0264
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0015 0.0013 0.0013
Brugia malayi hypothetical protein 0.0049 0.0264 0.1786
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.005 0.005
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.0695 0.2006
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0149 0.0399
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0286 0.1994 0.5733
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0025 0.018
Mycobacterium ulcerans epimerase 0.002 0.0052 0.0081
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0264 0.0264
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0049 0.0264 0.0264
Brugia malayi beta-lactamase family protein 0.0072 0.0433 0.2974
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0042 0.0211 0.4394
Leishmania major pyruvate kinase 0.0033 0.0149 0.1973
Mycobacterium tuberculosis Conserved protein 0.0072 0.0433 0.1234
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0149 0.0835
Trypanosoma brucei hypothetical protein, conserved 0.0016 0.0025 0.0183
Echinococcus multilocularis fmrfamide receptor 0.0049 0.0264 0.0264
Toxoplasma gondii thioredoxin reductase 0.0048 0.0251 0.5283
Echinococcus granulosus g protein coupled receptor 0.0049 0.0264 0.0264
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0264 0.0252
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0025 0.018
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0013 0.0015
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0116 0.0116
Schistosoma mansoni hypothetical protein 0.0049 0.0264 0.0252
Schistosoma mansoni growth hormone secretagogue receptor 0.0049 0.0264 0.0252
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0433 0.1234
Loa Loa (eye worm) phosphofructokinase 0.0109 0.0701 0.4905
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Trypanosoma cruzi DNA polymerase kappa, putative 0.008 0.0487 0.6882
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0025 0.0274
Echinococcus multilocularis lamin 0.0027 0.0102 0.0102
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0057 0.0324 0.0312
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Brugia malayi G-protein coupled receptor 0.0049 0.0264 0.1786
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0042 0.0296
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0049 0.0264 0.0264
Schistosoma mansoni chromobox protein 0.007 0.0414 0.0402
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0264 0.0252
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0264 0.0252
Echinococcus granulosus neuropeptide s receptor 0.051 0.3623 0.3623
Onchocerca volvulus 0.0049 0.0264 0.1544
Leishmania major hypothetical protein, conserved 0.0072 0.0433 0.6097
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0149 0.0835
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0264 0.0252
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0387 0.5435
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0219 0.3002
Echinococcus multilocularis dna polymerase kappa 0.008 0.0487 0.0487
Brugia malayi beta-lactamase 0.0072 0.0433 0.2974
Schistosoma mansoni DNA helicase recq1 0.002 0.005 0.0037
Echinococcus multilocularis solute carrier family 22 0.0015 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0088
Echinococcus multilocularis G-protein coupled receptor, putative 0.0049 0.0264 0.0264
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0042 0.0656
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.005 0.0276
Echinococcus multilocularis orexin receptor type 2 0.0049 0.0264 0.0264
Trichomonas vaginalis chromobox protein, putative 0.007 0.0414 0.0962
Echinococcus multilocularis chromobox protein 1 0.007 0.0414 0.0414
Brugia malayi hypothetical protein 0.0049 0.0264 0.1786
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.005 0.005
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.012 0.2378
Onchocerca volvulus 0.0049 0.0264 0.1544
Onchocerca volvulus 0.0049 0.0264 0.1544
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0212 0.0478
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0586 0.4181 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0049 0.0264 0.0264
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0264 0.0252
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0701 0.1652
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0212 0.0478
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0042 0.0224
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0042 0.0042
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0096 0.1839
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0387 0.2653
Trichomonas vaginalis chromobox protein, putative 0.007 0.0414 0.0962
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0015 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0143 0.0244
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0143 0.2887
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.0695 0.1899
Echinococcus granulosus 7TM GPCR rhodopsin 0.0049 0.0264 0.0264
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0149 0.0835
Brugia malayi RE15519p 0.0049 0.0264 0.1786
Schistosoma mansoni ap endonuclease 0.0019 0.0042 0.003
Brugia malayi Dopamine receptor 0.0049 0.0264 0.1786
Wolbachia endosymbiont of Brugia malayi cell division protein FtsI 0.0688 0.4918 1
Echinococcus granulosus pyruvate kinase 0.0017 0.003 0.003
Echinococcus multilocularis lamin dm0 0.0027 0.0102 0.0102
Echinococcus multilocularis musashi 0.0027 0.0102 0.0102
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0433 0.1234
Echinococcus granulosus neuropeptides capa receptor 0.0049 0.0264 0.0264
Echinococcus granulosus pyruvate kinase 0.0033 0.0149 0.0149
Echinococcus multilocularis chromobox protein 1 0.007 0.0414 0.0414
Treponema pallidum hypothetical protein 0.016 0.1072 0.1731
Mycobacterium tuberculosis Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.016 0.1072 0.3112
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0042 0.0061
Brugia malayi Sugar transporter family protein 0.0015 0.0013 0.0015
Echinococcus multilocularis neuropeptide receptor 0.0049 0.0264 0.0264
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0025 0.018
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0687
Echinococcus multilocularis dna polymerase eta 0.0079 0.0478 0.0478
Trypanosoma cruzi DNA polymerase kappa, putative 0.008 0.0487 0.6882
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0025 0.018
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0096 0.067
Mycobacterium ulcerans lipase LipD 0.0072 0.0433 0.0858
Leishmania major trypanothione reductase 0.0048 0.0251 0.3467
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Brugia malayi Sugar transporter family protein 0.0015 0.0013 0.0015
Schistosoma mansoni rotamase 0.0033 0.0149 0.0136
Schistosoma mansoni neuropeptide receptor 0.0049 0.0264 0.0252
Echinococcus granulosus pyruvate kinase 0.0017 0.003 0.003
Mycobacterium ulcerans hypothetical protein 0.0072 0.0433 0.0858
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0042 0.0431
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.012 0.2378
Schistosoma mansoni ap endonuclease 0.0019 0.0042 0.003
Brugia malayi glutathione reductase 0.0048 0.0251 0.1698
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.0783 0.2265
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0433 0.6097
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0025 0.018
Trichomonas vaginalis rotamase, putative 0.0033 0.0149 0.0327
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0149 0.0327
Leishmania major DNA polymerase eta, putative 0.0042 0.0211 0.2884
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0013 0.0015
Brugia malayi G protein-coupled receptor 0.0049 0.0264 0.1786
Brugia malayi hypothetical protein 0.0049 0.0264 0.1786
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0149 0.1973
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0487 0.6882
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0049 0.0264 0.0252
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.0695 0.2006
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Brugia malayi intermediate filament protein 0.0027 0.0102 0.0644
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0015 0.0013 0.0013
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0049 0.0264 0.0264
Brugia malayi ImpB/MucB/SamB family protein 0.0053 0.0292 0.1987
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0049 0.0264 0.0264
Echinococcus granulosus fmrfamide receptor 0.0049 0.0264 0.0264
Echinococcus multilocularis geminin 0.017 0.1142 0.1142
Mycobacterium leprae Probable penicillin-binding protein PbpA 0.0341 0.2389 0.6902
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Echinococcus granulosus hypothetical protein 0.0049 0.0264 0.0264
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.0783 0.2265
Mycobacterium leprae POSSIBLE PENICILLIN-BINDING LIPOPROTEIN 0.0441 0.3117 0.9049
Giardia lamblia DINP protein human, muc B family 0.006 0.0341 0.0787
Echinococcus granulosus Solute carrier family 22 5 0.104 0.7489 0.7489
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0264 0.0264
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0025 0.0103
Brugia malayi Flap endonuclease-1 0.0026 0.0096 0.0601
Plasmodium vivax DNA repair protein REV1, putative 0.0016 0.0025 0.0279
Onchocerca volvulus 0.0041 0.0207 0.1194
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0102 0.0713
Mycobacterium ulcerans hypothetical protein 0.0016 0.0025 0.0026
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0433 0.2974
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.022 0.3016
Brugia malayi neuropeptide F receptor 0.0049 0.0264 0.1786
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0049 0.0264 0.0252
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0013 0.0013
Treponema pallidum fructose-bisphosphate aldolase 0.0586 0.4181 0.6872
Echinococcus granulosus 6 phosphofructokinase 0.0109 0.0701 0.0701
Schistosoma mansoni pyruvate kinase 0.0017 0.003 0.0017
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.006 0.0341 0.4763
Echinococcus granulosus dna polymerase kappa 0.008 0.0487 0.0487
Echinococcus multilocularis serotonin receptor 0.0049 0.0264 0.0264
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0049 0.0264 0.0252
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0049 0.0264 0.1786
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0049 0.0264 0.1846
Brugia malayi Serotonin receptor 0.0049 0.0264 0.1786
Brugia malayi hypothetical protein 0.0049 0.0264 0.1786
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0049 0.0264 0.1846
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0088
Schistosoma mansoni biogenic amine receptor 0.0049 0.0264 0.0252
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0143 0.1894
Schistosoma mansoni intermediate filament proteins 0.0027 0.0102 0.0089
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0025 0.018
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0586 0.4181 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0049 0.0264 0.1786
Loa Loa (eye worm) hypothetical protein 0.0072 0.0433 0.3025
Brugia malayi GnHR receptor homolog 0.0049 0.0264 0.1786
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Echinococcus multilocularis neuropeptides capa receptor 0.0049 0.0264 0.0264
Echinococcus multilocularis pyruvate kinase 0.0017 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Echinococcus granulosus tm gpcr rhodopsin 0.0049 0.0264 0.0264
Onchocerca volvulus 0.0049 0.0264 0.1544
Brugia malayi major facilitator superfamily protein 0.0015 0.0013 0.0015
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0124 0.0111
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0049 0.0264 0.0252
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.019 0.0426
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0149 0.3007
Echinococcus multilocularis allatostatin A receptor 0.0049 0.0264 0.0264
Plasmodium falciparum DNA repair protein REV1, putative 0.0016 0.0025 0.0279
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0433 0.3025
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.005 0.0538
Echinococcus granulosus solute carrier family 22 0.0015 0.0013 0.0013
Echinococcus granulosus alpha 1A adrenergic receptor 0.0049 0.0264 0.0264
Loa Loa (eye worm) hypothetical protein 0.002 0.005 0.0347
Loa Loa (eye worm) TYRA-2 protein 0.0049 0.0264 0.1846
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.012 0.0258
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0586 0.4181 1
Trypanosoma brucei DNA polymerase IV, putative 0.008 0.0487 0.6882
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0341 0.4763
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0102 0.0713
Echinococcus multilocularis expressed protein 0.0033 0.0149 0.0149
Toxoplasma gondii 6-phosphofructokinase 0.003 0.012 0.2378
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0433 0.1123
Onchocerca volvulus 0.0027 0.0102 0.0548
Loa Loa (eye worm) neuropeptide F receptor 0.0049 0.0264 0.1846
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0324 0.2208
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Echinococcus multilocularis dro:myosuppressin receptor 0.0049 0.0264 0.0264
Mycobacterium tuberculosis Conserved protein 0.0072 0.0433 0.1234
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0025 0.0183
Loa Loa (eye worm) hypothetical protein 0.0072 0.0433 0.3025
Echinococcus multilocularis g protein coupled receptor 0.0049 0.0264 0.0264
Echinococcus granulosus dro:myosuppressin receptor 0.0049 0.0264 0.0264
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.0052 0.0294
Echinococcus multilocularis solute carrier family 22 0.0015 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0088
Chlamydia trachomatis transglycolase/transpeptidase 0.0339 0.2377 0.4807
Brugia malayi Tachykinin-like peptides receptor 99D 0.0049 0.0264 0.1786
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0025 0.018
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0102 0.0644
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0149 0.0326
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0025 0.0025
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.002 0.0052 0.0243
Mycobacterium ulcerans 6-phosphofructokinase 0.0109 0.0701 0.1408
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0013 0.0013
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0433 0.1234
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.022 0.3016
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0025 0.018
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0025 0.018
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0088
Mycobacterium ulcerans bifunctional penicillin-binding protein 1A/1B PonA1 0.0485 0.3439 0.7003
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0049 0.0264 0.0264
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0701 0.1652
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0049 0.0264 0.0264
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.012 0.2378
Onchocerca volvulus 0.0072 0.0433 0.258
Echinococcus granulosus pyruvate kinase 0.0033 0.0149 0.0149
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0433 0.1234
Brugia malayi Pre-SET motif family protein 0.0209 0.143 1
Echinococcus multilocularis serotonin receptor 0.0049 0.0264 0.0264
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Mycobacterium leprae Probable transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.016 0.1072 0.3011
Brugia malayi hypothetical protein 0.0015 0.0013 0.0015
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0433 0.1008
Echinococcus granulosus allatostatin A receptor 0.0049 0.0264 0.0264
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0264 0.0264
Echinococcus multilocularis g protein coupled receptor 0.0049 0.0264 0.0264
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.005 0.0089
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0075 0.0079
Echinococcus granulosus neuropeptide Y receptor 0.0049 0.0264 0.0264
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0296 0.2068
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.005 0.005
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.0701 0.069
Brugia malayi G-protein coupled receptor 0.0049 0.0264 0.1786
Trypanosoma cruzi DNA damage repair protein, putative 0.0016 0.0025 0.0183
Schistosoma mansoni hypothetical protein 0.0049 0.0264 0.0252
Onchocerca volvulus 0.0072 0.0433 0.258
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.012 0.0188
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0049 0.0264 0.0252
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0042 0.0087
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0042 0.0431
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0109 0.0701 0.2024
Mycobacterium ulcerans penicillin-binding lipoprotein 0.0441 0.3117 0.6345
Mycobacterium tuberculosis Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase 0.0163 0.1095 0.3179
Echinococcus multilocularis sex peptide receptor 0.0049 0.0264 0.0264
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0077 0.0465 0.1328
Echinococcus multilocularis solute carrier family 22 0.0015 0.0013 0.0013
Brugia malayi Bloom's syndrome protein homolog 0.002 0.005 0.0276
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0049 0.0264 0.0264
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0088
Mycobacterium ulcerans endonuclease IV 0.0077 0.0465 0.0924
Schistosoma mansoni DNA polymerase eta 0.0079 0.0478 0.0466
Echinococcus granulosus neuropeptide receptor 0.0049 0.0264 0.0264
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0124 0.0111
Mycobacterium tuberculosis Probable penicillin-binding protein PbpA 0.0341 0.2389 0.6984
Mycobacterium ulcerans DNA polymerase IV 0.008 0.0487 0.0969
Onchocerca volvulus 0.0049 0.0264 0.1544
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0049 0.0264 0.0264
Leishmania major DNA polymerase kappa, putative 0.0016 0.0025 0.0183
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Echinococcus granulosus G protein coupled receptor 139 0.0049 0.0264 0.0264
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0264 0.0264
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0251 0.0702
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0701 0.1652
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Schistosoma mansoni pyruvate kinase 0.0033 0.0149 0.0136
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Echinococcus granulosus geminin 0.017 0.1142 0.1142
Brugia malayi Serotonin receptor 0.0049 0.0264 0.1786
Brugia malayi putative neuropeptide receptor 0.0049 0.0264 0.1786
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0025 0.0274
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0212 0.1223
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0124 0.0111
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0042 0.0071
Onchocerca volvulus 0.0049 0.0264 0.1544
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Schistosoma mansoni alpha-1 adrenergic receptor 0.0049 0.0264 0.0252
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.0414 0.2893
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0264 0.0252
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0387 0.2706
Brugia malayi follicle stimulating hormone receptor 0.0049 0.0264 0.1786
Schistosoma mansoni adenoreceptor 0.0049 0.0264 0.0252
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0025 0.0025
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0433 0.0433
Echinococcus granulosus tm gpcr rhodopsin 0.0049 0.0264 0.0264
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0264 0.0252
Echinococcus multilocularis g-protein coupled receptor 0.0049 0.0264 0.0264
Echinococcus multilocularis neuropeptide Y receptor 0.0049 0.0264 0.0264
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0049 0.0264 0.0252
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.012 0.0258
Schistosoma mansoni biogenic amine (5HT) receptor 0.0049 0.0264 0.0252
Mycobacterium ulcerans bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 0.0482 0.3416 0.6956
Schistosoma mansoni neuropeptide receptor 0.0049 0.0264 0.0252
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0025 0.018
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0433 0.1008
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0433 0.6097
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0025 0.0025
Echinococcus multilocularis pyruvate kinase 0.0017 0.003 0.003
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0049 0.0264 0.0264
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0387 0.0387
Trypanosoma cruzi DNA polymerase eta, putative 0.0079 0.0478 0.6764
Schistosoma mansoni histamine h1 receptor 0.0049 0.0264 0.0252
Schistosoma mansoni neuropeptide F-like receptor 0.0049 0.0264 0.0252
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0433 0.6097
Loa Loa (eye worm) hypothetical protein 0.0031 0.0129 0.0899
Brugia malayi hypothetical protein 0.0049 0.0264 0.1786
Brugia malayi hypothetical protein 0.0049 0.0264 0.1786
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.012 0.0258
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.012 0.2378
Schistosoma mansoni myosin xvIII 0.0049 0.0264 0.0252
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0057 0.0324 0.4519
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0049 0.0264 0.1786
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.012 0.0258
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0052 0.0116
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0075 0.0523
Brugia malayi major facilitator superfamily protein 0.0015 0.0013 0.0015
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0049 0.0264 0.0264
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.005 0.0347
Brugia malayi neuropeptide F receptor 0.0049 0.0264 0.1786
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0042 0.0431
Trypanosoma brucei hypothetical protein, conserved 0.0016 0.0025 0.0183
Onchocerca volvulus Neuropeptide F receptor homolog 0.0049 0.0264 0.1544
Echinococcus multilocularis neuropeptides capa receptor 0.0049 0.0264 0.0264
Echinococcus granulosus orexin receptor type 2 0.0049 0.0264 0.0264
Schistosoma mansoni opsin-like receptor 0.0049 0.0264 0.0252
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0096 0.0199
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0025 0.003
Trichomonas vaginalis DNA polymerase eta, putative 0.008 0.0487 0.1137
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0387 0.5435
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0487 0.6882
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0025 0.0274
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0049 0.0264 0.1786
Loa Loa (eye worm) G-protein coupled receptor 0.0049 0.0264 0.1846
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0077 0.0465 0.32
Echinococcus granulosus bloom syndrome protein 0.002 0.005 0.005
Toxoplasma gondii exonuclease III APE 0.0019 0.0042 0.0656
Schistosoma mansoni biogenic amine receptor 0.0049 0.0264 0.0252
Loa Loa (eye worm) hypothetical protein 0.0072 0.0433 0.3025
Chlamydia trachomatis pyruvate kinase 0.0033 0.0149 0.0252
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0264 0.0252
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0049 0.0264 0.0264
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.012 0.0258
Loa Loa (eye worm) hypothetical protein 0.0072 0.0433 0.3025
Echinococcus granulosus lamin 0.0027 0.0102 0.0102
Mycobacterium leprae PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN 0.0482 0.3416 0.9932
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.003 0.0384
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0088
Leishmania major pyruvate kinase 0.0033 0.0149 0.1973
Echinococcus multilocularis microtubule associated protein 2 0.1385 1 1
Trypanosoma cruzi DNA damage repair protein, putative 0.0016 0.0025 0.0183
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0049 0.0264 0.0264
Echinococcus granulosus chromobox protein 1 0.007 0.0414 0.0414
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0049 0.0264 0.0252
Entamoeba histolytica recQ family helicase, putative 0.002 0.005 0.0018
Brugia malayi Sugar transporter family protein 0.0015 0.0013 0.0015
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0109 0.0701 0.1917
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0251 0.0251
Mycobacterium leprae Probable penicillin-binding membrane protein PbpB 0.0172 0.1156 0.3261
Brugia malayi hypothetical protein 0.0049 0.0264 0.1786
Echinococcus granulosus flap endonuclease 1 0.0026 0.0096 0.0096
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0149 0.1973
Trypanosoma brucei DNA polymerase IV, putative 0.008 0.0487 0.6882
Echinococcus granulosus g protein coupled receptor 0.0049 0.0264 0.0264
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0015 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Loa Loa (eye worm) glutathione reductase 0.0048 0.0251 0.1758
Echinococcus multilocularis neuropeptide s receptor 0.051 0.3623 0.3623
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.012 0.2378
Onchocerca volvulus 0.0049 0.0264 0.1544
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0025 0.018
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Onchocerca volvulus 0.0049 0.0264 0.1544
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0433 0.1234
Echinococcus granulosus biogenic amine 5HT receptor 0.0049 0.0264 0.0264
Brugia malayi hypothetical protein 0.0015 0.0013 0.0015
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0042 0.006
Loa Loa (eye worm) hypothetical protein 0.0077 0.0465 0.325
Brugia malayi Melatonin receptor type 1A 0.0049 0.0264 0.1786
Onchocerca volvulus 0.0031 0.0129 0.0712
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0053 0.0292 0.0292
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0264 0.0264
Echinococcus granulosus neuropeptide Y receptor 0.0049 0.0264 0.0264
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0025 0.018
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0387 0.0387
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0251 0.0251
Schistosoma mansoni terminal deoxycytidyl transferase 0.0053 0.0292 0.028
Echinococcus granulosus solute carrier family 22 0.0015 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0088
Mycobacterium ulcerans penicillin-binding membrane protein PbpB 0.0686 0.4905 1
Plasmodium falciparum thioredoxin reductase 0.0016 0.0025 0.0274
Plasmodium falciparum pyruvate kinase 0.0033 0.0149 0.3007
Loa Loa (eye worm) melatonin receptor type 1A 0.0049 0.0264 0.1846
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0088
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.005 0.0276
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0023 0.0073 0.1345
Trichomonas vaginalis conserved hypothetical protein 0.0485 0.3439 0.822
Loa Loa (eye worm) hypothetical protein 0.0039 0.019 0.133
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Onchocerca volvulus 0.0072 0.0433 0.258
Schistosoma mansoni neuropeptide receptor 0.0049 0.0264 0.0252
Echinococcus multilocularis g protein coupled receptor 0.0049 0.0264 0.0264
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0433 0.1234
Giardia lamblia Pyruvate kinase 0.0033 0.0149 0.0326
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0487 0.6882
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0286 0.1994 0.5821
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.0701 0.4905
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0015 0.0013 0.0013
Echinococcus granulosus peptide allatostatin:somatostatin 0.0049 0.0264 0.0264
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0433 0.1008
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0013 0.0013
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0049 0.0264 0.1846
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0057 0.0324 0.0914
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0042 0.0029
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.0701 0.069
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0088
Brugia malayi AKH receptor 0.0049 0.0264 0.1786
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0586 0.4181 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0586 0.4181 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.0695 0.2006
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.005 0.082
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0487 0.6882
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.012 0.0258
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0701 0.1593
Mycobacterium tuberculosis Conserved protein 0.0072 0.0433 0.1234
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0042 0.0071
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0124 0.2457
Toxoplasma gondii endonuclease IV APN 0.0077 0.0465 1
Brugia malayi Heterochromatin protein 1 0.007 0.0414 0.2841
Echinococcus granulosus tm gpcr rhodopsin 0.0049 0.0264 0.0264
Brugia malayi polk-prov protein 0.0043 0.0219 0.1472
Echinococcus granulosus solute carrier family 22 0.0015 0.0013 0.0013
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0286 0.1994 0.4049
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0264 0.0264
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0324 0.0636
Loa Loa (eye worm) hypothetical protein 0.0072 0.0433 0.3025
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0264 0.0264
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0487 0.6882
Mycobacterium ulcerans penicillin-binding protein PbpA 0.0341 0.2389 0.4858
Brugia malayi ORL1-like opioid receptor 0.0049 0.0264 0.1786
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Echinococcus granulosus g-protein coupled receptor 0.0049 0.0264 0.0264
Schistosoma mansoni microtubule-associated protein tau 0.1385 1 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.005 0.0538
Schistosoma mansoni hypothetical protein 0.017 0.1142 0.1131
Onchocerca volvulus 0.0049 0.0264 0.1544
Brugia malayi Thioredoxin reductase 0.0048 0.0251 0.1698
Schistosoma mansoni neuropeptide receptor 0.0049 0.0264 0.0252
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0096 0.0096
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0701 0.1652
Loa Loa (eye worm) hypothetical protein 0.002 0.0052 0.0365
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.005 0.0089
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0049 0.0264 0.0252
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0088
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0586 0.4181 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0049 0.0264 0.0264
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0433 0.042
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0053 0.0292 0.028
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0049 0.0264 0.0264
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0149 0.0285
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0264 0.0264
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0042 0.0431
Schistosoma mansoni neuropeptide f receptor 76f 0.0049 0.0264 0.0252
Plasmodium falciparum glutathione reductase 0.0048 0.0251 0.5283
Echinococcus granulosus sex peptide receptor 0.0049 0.0264 0.0264
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0487 0.6882
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0586 0.4181 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0013 0.0088
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.143 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0049 0.0264 0.0264
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0025 0.0036
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0586 0.4181 1
Trypanosoma brucei unspecified product 0.0037 0.0172 0.2317
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0049 0.0264 0.0264
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0025 0.018
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0487 0.6882
Schistosoma mansoni pyruvate kinase 0.0033 0.0149 0.0136
Leishmania major DNA polymerase eta, putative 0.0079 0.0478 0.6764
Onchocerca volvulus 0.0049 0.0264 0.1544
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0264 0.0264
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0025 0.0274
Echinococcus multilocularis G protein coupled receptor 139 0.0049 0.0264 0.0264
Echinococcus granulosus biogenic amine 5HT receptor 0.0049 0.0264 0.0264
Echinococcus granulosus intermediate filament protein 0.0027 0.0102 0.0102
Trichomonas vaginalis rotamase, putative 0.0033 0.0143 0.0313
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0149 0.1039
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0149 0.1973
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.005 0.005
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0149 0.0326
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0025 0.018
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0025 0.003
Trypanosoma brucei unspecified product 0.0037 0.0172 0.2317
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0143 0.1894
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0149 0.0975
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0053 0.0292 0.0292
Leishmania major DNA polymerase kappa, putative 0.006 0.0341 0.4763
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.012 0.0157
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0049 0.0264 0.0264
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0124 0.0124
Onchocerca volvulus 0.0049 0.0264 0.1544
Echinococcus multilocularis neuropeptide Y receptor 0.0049 0.0264 0.0264
Giardia lamblia DNA damage repair protein 0.0016 0.0025 0.003
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0049 0.0264 0.1846
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0264 0.0264
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0049 0.0264 0.1786
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0013 0.0015
Brugia malayi hypothetical protein 0.0049 0.0264 0.1786
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.005 0.0089
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0077 0.0465 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.008 0.0487 0.6882
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.0695 0.2006
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.0695 0.2006
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0015 0.0013 0.0013
Brugia malayi G protein-coupled receptor F59B2.13 0.0049 0.0264 0.1786
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0143 0.1894
Onchocerca volvulus 0.0238 0.1641 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0462 0.3276 0.9588
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0251 0.5283
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0053 0.0292 0.2046
Echinococcus multilocularis pyruvate kinase 0.0026 0.0097 0.0097
Plasmodium vivax glutathione reductase, putative 0.0048 0.0251 0.5283
Echinococcus granulosus pyruvate kinase 0.0017 0.003 0.003
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0049 0.0264 0.1544
Plasmodium falciparum flap endonuclease 1 0.0026 0.0096 0.1839
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0049 0.0264 0.0264
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0264 0.0252
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.0701 0.4905
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0107 0.0226
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0143 0.1894
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.001 0.0073
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0107 0.0226
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0025 0.0183
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0077 0.0465 1
Chlamydia trachomatis transglycolase/transpeptidase 0.0688 0.4918 1
Plasmodium vivax SET domain protein, putative 0.003 0.0124 0.2457
Plasmodium falciparum thioredoxin reductase 0.0048 0.0251 0.5283
Mycobacterium tuberculosis Conserved hypothetical protein 0.0053 0.0292 0.0822
Treponema pallidum penicillin-binding protein (pbp-3) 0.0846 0.6072 1
Echinococcus multilocularis fmrfamide receptor 0.0049 0.0264 0.0264
Trypanosoma brucei DNA damage repair protein, putative 0.0016 0.0025 0.0183
Loa Loa (eye worm) hypothetical protein 0.0043 0.0219 0.1534
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.005 0.0089
Schistosoma mansoni hypothetical protein 0.0049 0.0264 0.0252
Mycobacterium tuberculosis Possible penicillin-binding lipoprotein 0.0441 0.3117 0.9121
Mycobacterium ulcerans hypothetical protein 0.002 0.0052 0.0081
Schistosoma mansoni hypothetical protein 0.0049 0.0264 0.0252
Echinococcus granulosus dna polymerase eta 0.0079 0.0478 0.0478
Brugia malayi sulfakinin receptor protein 0.0049 0.0264 0.1786
Brugia malayi Dopamine receptor protein 2 0.0049 0.0264 0.1786
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.0783 0.2159
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0096 0.1207
Schistosoma mansoni amine GPCR 0.0049 0.0264 0.0252
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0088
Schistosoma mansoni lamin 0.0027 0.0102 0.0089
Brugia malayi larval opioid receptor 0.0049 0.0264 0.1786
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.0783 0.2265
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0219 0.3002
Onchocerca volvulus 0.0049 0.0264 0.1544
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.008 0.0487 0.1137
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0049 0.0264 0.0264
Echinococcus multilocularis neuropeptide receptor A26 0.051 0.3623 0.3623
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0487 0.6882
Echinococcus granulosus somatostatin receptor 0.0049 0.0264 0.0264
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0264 0.0264
Brugia malayi 6-phosphofructokinase 0.0109 0.0701 0.4868
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0433 0.0858
Mycobacterium leprae PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE 0.0485 0.3439 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0042 0.0042
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0124 0.0124
Brugia malayi hypothetical protein 0.0049 0.0264 0.1786
Echinococcus granulosus lamin dm0 0.0027 0.0102 0.0102
Onchocerca volvulus 0.0049 0.0264 0.1544
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0149 0.1973
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0049 0.0264 0.0252
Loa Loa (eye worm) sugar transporter 0.0015 0.0013 0.0088
Brugia malayi Pre-SET motif family protein 0.003 0.0124 0.0798
Schistosoma mansoni DNA helicase recq5 0.002 0.005 0.0037
Trypanosoma brucei DNA damage repair protein, putative 0.0016 0.0025 0.0183
Echinococcus multilocularis solute carrier family 22 0.0015 0.0013 0.0013
Echinococcus multilocularis pyruvate kinase 0.0033 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0088
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.022 0.3016
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0324 0.0324
Brugia malayi chromobox protein homolog 3 0.0039 0.019 0.1266
Echinococcus multilocularis pyruvate kinase 0.0017 0.003 0.003
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0586 0.4181 1
Treponema pallidum penicillin-binding protein (pbp-2) 0.0485 0.3439 0.5646
Brugia malayi 6-phosphofructokinase 0.0109 0.0701 0.4868
Leishmania major DNA damage repair protein, putative 0.0016 0.0025 0.0183
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0096 0.1839
Echinococcus granulosus neuropeptide receptor 0.0049 0.0264 0.0264
Trypanosoma cruzi DNA polymerase eta, putative 0.0042 0.0211 0.2884
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0096 0.0199
Loa Loa (eye worm) hypothetical protein 0.0072 0.0433 0.3025
Schistosoma mansoni flap endonuclease-1 0.0024 0.0077 0.0065
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0149 0.1039
Loa Loa (eye worm) hypothetical protein 0.003 0.0124 0.0865
Mycobacterium tuberculosis Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen 0.0482 0.3416 1
Echinococcus granulosus g protein coupled receptor 0.0049 0.0264 0.0264
Echinococcus multilocularis neuropeptide FF receptor 2 0.0049 0.0264 0.0264
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0025 0.0025
Loa Loa (eye worm) sugar transporter 0.0015 0.0013 0.0088
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.017 0.1142 0.1131
Brugia malayi hypothetical protein 0.0015 0.0013 0.0015
Loa Loa (eye worm) hypothetical protein 0.0023 0.0075 0.0523
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0124 0.0124
Schistosoma mansoni biogenic amine receptor 0.0049 0.0264 0.0252
Schistosoma mansoni opsin-like receptor 0.0049 0.0264 0.0252
Plasmodium falciparum pyruvate kinase 2 0.0017 0.003 0.0384
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0387 0.5435
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0251 0.1758
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0264 0.0264
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0088
Schistosoma mansoni amine GPCR 0.0049 0.0264 0.0252
Loa Loa (eye worm) hypothetical protein 0.0027 0.0102 0.0713
Mycobacterium ulcerans beta-lactamase 0.0072 0.0433 0.0858
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0025 0.003
Mycobacterium tuberculosis Probable reductase 0.0108 0.0695 0.2006
Schistosoma mansoni amine GPCR 0.0049 0.0264 0.0252
Schistosoma mansoni amine GPCR 0.0049 0.0264 0.0252
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0324 0.0636
Trichomonas vaginalis esterase, putative 0.0072 0.0433 0.1008
Onchocerca volvulus 0.0049 0.0264 0.1544
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0088
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.0701 1
Echinococcus multilocularis neuropeptide receptor 0.0049 0.0264 0.0264
Brugia malayi hypothetical protein 0.0049 0.0264 0.1786
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0586 0.4181 1
Loa Loa (eye worm) G-protein coupled receptor 0.0049 0.0264 0.1846
Brugia malayi phosphofructokinase 0.0109 0.0701 0.4868
Echinococcus granulosus neuropeptide receptor A26 0.051 0.3623 0.3623
Echinococcus granulosus tachykinin peptides receptor 99D 0.0049 0.0264 0.0264
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0109 0.0701 0.1119
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0387 0.5435
Onchocerca volvulus 0.0049 0.0264 0.1544
Brugia malayi Dopamine receptor protein 1 0.0049 0.0264 0.1786
Trypanosoma brucei DNA polymerase eta, putative 0.0079 0.0478 0.6764
Schistosoma mansoni DNA polymerase IV / kappa 0.0016 0.0025 0.0013
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0025 0.0025
Trichomonas vaginalis set domain proteins, putative 0.0238 0.1641 0.3906
Echinococcus multilocularis 6 phosphofructokinase 0.0109 0.0701 0.0701
Brugia malayi beta-lactamase family protein 0.0072 0.0433 0.2974
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0049 0.0264 0.0252
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0042 0.0071
Mycobacterium leprae Probable lipase LipE 0.0072 0.0433 0.1123
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0701 0.1593
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Loa Loa (eye worm) hypothetical protein 0.0079 0.0478 0.3346
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0013 0.0088
Echinococcus granulosus serotonin receptor 0.0049 0.0264 0.0264
Echinococcus granulosus chromobox protein 1 0.007 0.0414 0.0414
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0025 0.0012
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0149 0.0278
Schistosoma mansoni chromobox protein 0.007 0.0414 0.0402
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0433 0.042
Schistosoma mansoni opsin-like receptor 0.0049 0.0264 0.0252
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Echinococcus multilocularis bloom syndrome protein 0.002 0.005 0.005
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0015 0.0013 0.0013
Chlamydia trachomatis endonuclease IV 0.0077 0.0465 0.0899
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0025 0.018
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0096 0.1207
Brugia malayi ImpB/MucB/SamB family protein 0.0079 0.0478 0.3297
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.003 0.0384
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0149 0.0973
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.012 0.0258
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0487 0.6882
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0049 0.0264 0.0252
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0096 0.1207
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0025 0.018
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0025 0.0274
Leishmania major ATP-dependent phosphofructokinase 0.0109 0.0701 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0433 0.1234
Schistosoma mansoni amine GPCR 0.0049 0.0264 0.0252
Onchocerca volvulus 0.0049 0.0264 0.1544
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.012 0.0258
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.002 0.0052 0.0081
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0264 0.0264
Trypanosoma brucei chrX additional, unordered contigs 0.0016 0.0025 0.0183
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Giardia lamblia Pyruvate kinase 0.0017 0.003 0.0042
Schistosoma mansoni neuropeptide F-like receptor 0.0049 0.0264 0.0252
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0149 0.0973
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0264 0.0264
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0701 0.1593
Schistosoma mansoni biogenic amine (5HT) receptor 0.0049 0.0264 0.0252
Treponema pallidum penicillin-binding protein (pbp-1) 0.0688 0.4918 0.8091
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0149 0.3007
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0025 0.018
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0015 0.0013 0.0013
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0149 0.1039
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0025 0.0274
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0042 0.0656
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0586 0.4181 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.005 0.0538
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0433 0.0858
Echinococcus granulosus solute carrier family 22 0.0015 0.0013 0.0013
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.0207 0.0195
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.012 0.2378
Brugia malayi putative neuropeptide receptor NPR1 0.0049 0.0264 0.1786
Loa Loa (eye worm) beta-lactamase 0.0072 0.0433 0.3025
Echinococcus multilocularis pyruvate kinase 0.0033 0.0149 0.0149
Mycobacterium ulcerans serine/threonine-protein kinase B PknB 0.016 0.1072 0.2165
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0433 0.1008
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.0701 1
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.1846
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0433 0.0433
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0184 0.0184
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0264 0.0264
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0433 0.929
Loa Loa (eye worm) hypothetical protein 0.0033 0.0149 0.1039
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0049 0.0264 0.0252
Loa Loa (eye worm) RecQ helicase 0.002 0.005 0.0347
Onchocerca volvulus 0.0049 0.0264 0.1544

Activities

Activity type Activity value Assay description Source Reference
CC50 (functional) = 388 uM Cytotoxic concentration required to reduce the viability of mock-infected MT-4 cells by 50%. ChEMBL. 1995896
CC50 (functional) = 388 uM Cytotoxic concentration required to reduce the viability of mock-infected MT-4 cells by 50%. ChEMBL. 1995896
IC50 (functional) = 122 uM Effective concentration required to achieve 50% protection of MT-4 cells against the cytopathic effect of HIV-1. ChEMBL. 1995896
Selectivity index (functional) = 3 Selectivity index measured as the ratio of CC50/IC50 values. ChEMBL. 1995896

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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