Detailed information for compound 282890

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 526.625 | Formula: C28H38N4O6
  • H donors: 3 H acceptors: 5 LogP: 1.66 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C1NC(C)(C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N2C(C(=O)NC1CCCCCC(=O)[C@@H]1CO1)CCC2
  • InChi: 1S/C28H38N4O6/c1-28(2)27(37)30-20(16-18-10-5-3-6-11-18)26(36)32-15-9-13-21(32)25(35)29-19(24(34)31-28)12-7-4-8-14-22(33)23-17-38-23/h3,5-6,10-11,19-21,23H,4,7-9,12-17H2,1-2H3,(H,29,35)(H,30,37)(H,31,34)/t19?,20-,21?,23-/m1/s1
  • InChiKey: SGYJGGKDGBXCNY-UFNITMFUSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis histone deacetylase 6 0.0452 0.192 0.2086
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.003 0.0136
Leishmania major DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0007 0.0017
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0114 0.0431 0.0427
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0187 0.0199
Loa Loa (eye worm) hypothetical protein 0.0189 0.0761 0.3948
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0158 0.0802
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0111 0.0497
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0189 0.0761 0.0757
Brugia malayi hypothetical protein 0.0036 0.0085 0.0426
Loa Loa (eye worm) hypothetical protein 0.0023 0.003 0.0136
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0089 0.0321 0.0317
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0202 0.1035
Schistosoma mansoni hypothetical protein 0.0033 0.0072 0.0068
Mycobacterium ulcerans hypothetical protein 0.0023 0.003 0.0237
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0189 0.0761 0.3948
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0007 0.0004
Loa Loa (eye worm) hypothetical protein 0.0071 0.0238 0.1224
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.1059 0.5015
Brugia malayi serine/threonine-protein kinase plk-2 0.0186 0.0747 0.3878
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.1059 0.5015
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0202 0.0198
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0441
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0023 0.0028 0.0125
Brugia malayi nuclear receptor NHR-67 0.0089 0.0321 0.1653
Entamoeba histolytica hypothetical protein 0.0036 0.0085 0.0446
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0053 0.0257
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Brugia malayi hypothetical protein 0.01 0.0368 0.1899
Schistosoma mansoni serine/threonine protein kinase 0.0087 0.0311 0.0308
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0087 0.0311 0.1604
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0441
Loa Loa (eye worm) hypothetical protein 0.0021 0.0021 0.0088
Entamoeba histolytica protein kinase, putative 0.0087 0.0311 0.1731
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0007 0.0017
Brugia malayi hypothetical protein 0.0034 0.0076 0.0377
Onchocerca volvulus 0.0042 0.0111 0.0402
Schistosoma mansoni retinoid-x-receptor (RXR) 0.01 0.0368 0.0364
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.067 0.3161
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0215 0.0211
Entamoeba histolytica serine/threonine protein kinase, putative 0.0186 0.0747 0.421
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Trypanosoma cruzi histone deacetylase, putative 0.0197 0.0797 0.4139
Schistosoma mansoni polycystin 1-related 0.0079 0.0275 0.0272
Mycobacterium ulcerans hydrolase 0.0139 0.0541 0.4924
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0189 0.0761 0.3948
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Toxoplasma gondii peptidase, M28 family protein 0.0042 0.0111 0.0561
Leishmania major hypothetical protein, conserved 0.0042 0.0111 0.0561
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Trichomonas vaginalis Clan MH, family M28, aminopeptidase S-like metallopeptidase 0.0042 0.0111 0.0497
Brugia malayi photoreceptor-specific nuclear receptor 0.0189 0.0761 0.3948
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0189 0.0761 0.0824
Schistosoma mansoni acetylcholine receptor subunit beta 0.0023 0.0028 0.0024
Schistosoma mansoni hypothetical protein 0.0023 0.0031 0.0027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0189 0.0761 0.3948
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.003 0.0237
Echinococcus granulosus nAChR subunit 0.0059 0.0188 0.0201
Schistosoma mansoni histone deacetylase 4 5 0.0452 0.192 0.1917
Loa Loa (eye worm) hypothetical protein 0.0063 0.0204 0.1043
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0059 0.0188 0.0963
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.0303 0.4084
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0166 0.0658 0.0654
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Brugia malayi tailless protein 0.0089 0.0321 0.1653
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0202 0.0198
Leishmania major glutaminyl cyclase, putative 0.0042 0.0111 0.0561
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0189 0.0761 0.0757
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0059 0.0188 0.0201
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0089 0.0321 0.0345
Brugia malayi Steroid receptor seven-up type 2 0.0189 0.0761 0.3948
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0202 0.0216
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.067 0.3161
Trypanosoma cruzi polo-like protein kinase, putative 0.0186 0.0747 0.3878
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0215 0.023
Schistosoma mansoni hypothetical protein 0.0162 0.0641 0.0638
Loa Loa (eye worm) hypothetical protein 0.0114 0.0431 0.223
Trypanosoma cruzi glutaminyl cyclase, putative 0.0042 0.0111 0.0561
Entamoeba histolytica hypothetical protein 0.0025 0.0037 0.0168
Brugia malayi nuclear hormone receptor family member odr-7 0.0089 0.0321 0.1653
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0007 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0059 0.0188 0.0963
Toxoplasma gondii histone deacetylase HDAC2 0.0417 0.1765 0.9188
Loa Loa (eye worm) ACC-1 protein 0.0059 0.0188 0.0963
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0095 0.0345 0.4648
Mycobacterium ulcerans hypothetical protein 0.0042 0.0111 0.0983
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.067 0.3161
Brugia malayi Matrixin family protein 0.0114 0.0431 0.223
Onchocerca volvulus 0.0114 0.0431 0.1942
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0004 0.0002
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0185 0.0742 0.3852
Trichomonas vaginalis glutaminase, putative 0.0265 0.1094 0.5183
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.0382 0.1974
Entamoeba histolytica hypothetical protein 0.0087 0.0311 0.1731
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.0303 0.4084
Schistosoma mansoni neurotransmitter gated ion channel 0.0023 0.0028 0.0024
Leishmania major eukaryotic initiation factor 4a, putative 0.0185 0.0742 0.3852
Echinococcus granulosus histone deacetylase 8 0.0197 0.0797 0.0863
Brugia malayi nicalin 0.0042 0.0111 0.0561
Trypanosoma brucei histone deacetylase, putative 0.0452 0.192 1
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.1059 0.5015
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0021 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0189 0.0761 0.3948
Loa Loa (eye worm) histone deacetylase 1 0.0417 0.1765 0.9188
Toxoplasma gondii histone deacetylase HDAC1 0.0452 0.192 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0085 0.0303 0.5345
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0189 0.0761 0.0824
Loa Loa (eye worm) GABA receptor subunit 0.0036 0.0088 0.0441
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0021 0.0088
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0059 0.0188 0.0963
Loa Loa (eye worm) hypothetical protein 0.0125 0.048 0.2486
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.003 0.0237
Echinococcus granulosus tumor protein p63 0.033 0.1383 0.1501
Plasmodium falciparum flap endonuclease 1 0.0028 0.0053 0.0257
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0059 0.0188 0.0185
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0007 0.0017
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0007 0.0017
Loa Loa (eye worm) hypothetical protein 0.0189 0.0761 0.3948
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0094 0.0098
Schistosoma mansoni nAChR subunit 0.0023 0.0028 0.0024
Loa Loa (eye worm) hypothetical protein 0.0148 0.0578 0.2998
Entamoeba histolytica hypothetical protein 0.0036 0.0088 0.0463
Mycobacterium leprae PROBABLE HYDROLASE 0.0139 0.0541 1
Brugia malayi eukaryotic initiation factor 4A 0.0185 0.0742 0.3852
Loa Loa (eye worm) hypothetical protein 0.0417 0.1765 0.9188
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0072 0.0354
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.0303 0.4084
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0072 0.0354
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0187 0.0955
Echinococcus granulosus histone deacetylase 1 0.0417 0.1765 0.1917
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0021 0.0152
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0189 0.0761 0.3948
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0139 0.0541 0.2802
Schistosoma mansoni nAChR subunit 0.0059 0.0188 0.0185
Loa Loa (eye worm) hypothetical protein 0.0189 0.0761 0.3948
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.01 0.0368 0.0364
Echinococcus multilocularis glycine receptor subunit beta 0.0059 0.0188 0.0201
Echinococcus granulosus histone deacetylase 3 0.0417 0.1765 0.1917
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0059 0.0188 0.0201
Brugia malayi FXNA 0.0042 0.0111 0.0561
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0189 0.0761 0.3948
Onchocerca volvulus 0.0059 0.0188 0.0773
Brugia malayi histone deacetylase 3 (HD3) 0.0417 0.1765 0.9188
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0021 0.0065
Plasmodium falciparum histone deacetylase, putative 0.0452 0.192 1
Brugia malayi MH2 domain containing protein 0.013 0.0502 0.2599
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.067 0.3161
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0004 0.5
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0189 0.0761 0.3948
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0059 0.0188 0.0201
Schistosoma mansoni hypothetical protein 0.0164 0.0651 0.0647
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0296 0.1233 0.6413
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.003 0.013
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0036 0.0088 0.0085
Plasmodium vivax glutathione reductase, putative 0.0037 0.0092 0.0462
Brugia malayi AMP-binding enzyme family protein 0.0023 0.003 0.0136
Loa Loa (eye worm) hypothetical protein 0.01 0.0368 0.1899
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0158 0.0802
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0007 0.0004
Echinococcus granulosus histone deacetylase 7 0.0452 0.192 0.2086
Echinococcus granulosus Nuclear hormone receptor HR96 0.0089 0.0321 0.0345
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0007 0.0004
Brugia malayi nuclear receptor RXR 0.01 0.0368 0.1899
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0087 0.0311 0.1604
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0441
Echinococcus multilocularis muscleblind protein 0.0163 0.0646 0.0699
Onchocerca volvulus 0.0089 0.0321 0.141
Schistosoma mansoni neurotransmitter gated ion channel 0.0023 0.0028 0.0024
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0189 0.0761 0.3529
Schistosoma mansoni retinoic acid receptor RXR 0.0189 0.0761 0.0757
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0189 0.0761 0.0757
Toxoplasma gondii thioredoxin reductase 0.0037 0.0092 0.0462
Echinococcus multilocularis nAChR subunit 0.0059 0.0188 0.0201
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.0747 0.3529
Toxoplasma gondii histone deacetylase HDAC4 0.0197 0.0797 0.4139
Trypanosoma brucei trypanothione reductase 0.0037 0.0092 0.0462
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.0747 0.3529
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0059 0.0188 0.0185
Onchocerca volvulus Fxna peptidase homolog 0.0042 0.0111 0.0402
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0111 0.0497
Leishmania major histone deacetylase, putative 0.0452 0.192 1
Brugia malayi Flap endonuclease-1 0.0028 0.0053 0.0257
Echinococcus multilocularis geminin 0.0164 0.0651 0.0704
Brugia malayi AMP-binding enzyme family protein 0.0023 0.003 0.0136
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0189 0.0761 0.0824
Brugia malayi RNA binding protein 0.0123 0.0471 0.2436
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0441
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0021 0.0088
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0059 0.0188 0.0963
Loa Loa (eye worm) hypothetical protein 0.0042 0.0111 0.0561
Onchocerca volvulus Putative nachr subunit 0.0059 0.0188 0.0773
Onchocerca volvulus 0.0062 0.0202 0.0839
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.0382 0.1974
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0089 0.0321 0.1653
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0089 0.0321 0.0345
Echinococcus granulosus eukaryotic initiation factor 4A 0.0185 0.0742 0.0804
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.003 0.0136
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0021 0.0092
Trypanosoma cruzi glutaminyl cyclase, putative 0.0042 0.0111 0.0561
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0023 0.0028 0.0125
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0095 0.0099
Trichomonas vaginalis set domain proteins, putative 0.0494 0.2104 1
Loa Loa (eye worm) hypothetical protein 0.0189 0.0761 0.3948
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0089 0.0321 0.0345
Echinococcus granulosus nuclear receptor nhr 48 0.0089 0.0321 0.0345
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0059 0.0188 0.0963
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0007 0.0017
Echinococcus granulosus glycine receptor subunit alpha 1 0.0059 0.0188 0.0201
Echinococcus multilocularis global transcription activator snf2l2 0.0073 0.0251 0.0269
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Schistosoma mansoni helicase 0.0073 0.0251 0.0247
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0059 0.0188 0.0963
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0059 0.0188 0.0963
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0021 0.0152
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0187 0.0183
Echinococcus granulosus dual specificity 0.0087 0.0311 0.0335
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0059 0.0188 0.0963
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.003 0.0136
Trypanosoma brucei polo-like protein kinase 0.0186 0.0747 0.3878
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.1059 0.5015
Trichomonas vaginalis histone deacetylase, putative 0.0417 0.1765 0.8381
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0202 0.0198
Echinococcus granulosus thyroid hormone receptor alpha 0.0089 0.0321 0.0345
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0007 0.0003
Echinococcus granulosus histone deacetylase 6 0.046 0.1953 0.2122
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Loa Loa (eye worm) ACC-1 protein 0.0059 0.0188 0.0963
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0189 0.0761 0.3948
Loa Loa (eye worm) hypothetical protein 0.0023 0.003 0.0136
Plasmodium falciparum thioredoxin reductase 0.0037 0.0092 0.0462
Brugia malayi Cation transporter family protein 0.0059 0.0188 0.0963
Schistosoma mansoni histone deacetylase 4 5 0.0452 0.192 0.1917
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.0747 0.3529
Schistosoma mansoni microtubule-associated protein tau 0.2103 0.919 0.919
Loa Loa (eye worm) TAR-binding protein 0.0123 0.0471 0.2436
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0023 0.0028 0.0026
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0085 0.0089
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0004 0.0052
Trichomonas vaginalis histone deacetylase, putative 0.0417 0.1765 0.8381
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0417 0.1765 0.8381
Loa Loa (eye worm) RNA binding protein 0.0123 0.0471 0.2436
Plasmodium falciparum histone deacetylase 2 0.0452 0.192 1
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.0502 0.2599
Brugia malayi Nuclear hormone receptor-like 1 0.01 0.0368 0.1899
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0185 0.0742 0.3852
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0095 0.0345 0.4648
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0089 0.0321 0.0345
Plasmodium vivax RNA helicase-1, putative 0.0185 0.0742 0.3852
Schistosoma mansoni glutaminyl cyclase (M28 family) 0.0262 0.1081 0.1077
Brugia malayi BRM protein 0.0073 0.0251 0.1289
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0092 0.0462
Onchocerca volvulus 0.0059 0.0188 0.0773
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.1059 0.5015
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0062 0.0202 0.0198
Brugia malayi leucyl aminopeptidase 0.0042 0.0111 0.0561
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0158 0.0802
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0007 0.0017
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0059 0.0188 0.0963
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0002
Toxoplasma gondii histone deacetylase HDAC3 0.0417 0.1765 0.9188
Brugia malayi Nuclear hormone receptor-like 1 0.0189 0.0761 0.3948
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0028 0.0125
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0037 0.0033
Echinococcus multilocularis endoplasmic reticulum metallopeptidase 1 0.0042 0.0111 0.0117
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0037 0.0171
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0059 0.0188 0.0963
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0023 0.0028 0.0026
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0189 0.0761 0.0824
Echinococcus granulosus glycine receptor subunit alpha 1 0.0059 0.0188 0.0201
Plasmodium vivax SET domain protein, putative 0.0062 0.0202 0.1035
Schistosoma mansoni thyroid hormone receptor 0.0189 0.0761 0.0757
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0036 0.0088 0.0441
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0007 0.0017
Loa Loa (eye worm) hypothetical protein 0.01 0.0368 0.1899
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0257 0.1059 0.5505
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0028 0.0125
Onchocerca volvulus 0.0036 0.0088 0.0292
Schistosoma mansoni histone deacetylase 1 2 3 0.0197 0.0797 0.0793
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0189 0.0761 0.0824
Trichomonas vaginalis histone deacetylase, putative 0.0417 0.1765 0.8381
Giardia lamblia Histone deacetylase 0.0417 0.1765 1
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0037 0.0171
Brugia malayi Nuclear hormone receptor E75 0.0089 0.0321 0.1653
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0021 0.0088
Echinococcus granulosus glycine receptor subunit beta 0.0059 0.0188 0.0201
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.003 0.0237
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0036 0.0088 0.0441
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0092 0.0462
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0189 0.0761 0.3948
Loa Loa (eye worm) matrix metalloproteinase 0.0114 0.0431 0.223
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0334 0.1561
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0158 0.0802
Brugia malayi orphan nuclear receptor NR2E1 0.0089 0.0321 0.1653
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0053 0.0257
Echinococcus granulosus neuropeptide receptor A26 0.0517 0.2206 0.2397
Schistosoma mansoni DNA polymerase eta 0.0021 0.0021 0.0017
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0215 0.1101
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0059 0.0188 0.0201
Leishmania major eukaryotic initiation factor 4a, putative 0.0185 0.0742 0.3852
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0158 0.0802
Echinococcus granulosus glutaminyl peptide cyclotransferase 0.0262 0.1081 0.1172
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.0747 0.3529
Echinococcus multilocularis ecdysone induced protein 78C 0.0189 0.0761 0.0824
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.003 0.0237
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0037 0.0171
Schistosoma mansoni hypothetical protein 0.0036 0.0085 0.0082
Onchocerca volvulus Matrilysin homolog 0.0114 0.0431 0.1942
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0007 0.0017
Trypanosoma brucei histone deacetylase 1 0.0417 0.1765 0.9188
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0215 0.1101
Brugia malayi hypothetical protein 0.0089 0.0321 0.1653
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Trypanosoma brucei histone deacetylase 3 0.0452 0.192 1
Brugia malayi Cation transporter family protein 0.0059 0.0188 0.0963
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0053 0.0257
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0334 0.1561
Schistosoma mansoni glutaminyl-peptide cyclotransferase-related 0.0042 0.0111 0.0107
Loa Loa (eye worm) hypothetical protein 0.0189 0.0761 0.3948
Brugia malayi ecdysteroid receptor 0.0189 0.0761 0.3948
Echinococcus granulosus GPCR family 2 0.0033 0.0072 0.0074
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0087 0.0311 0.1604
Brugia malayi Protein kinase domain containing protein 0.0087 0.0311 0.1604
Onchocerca volvulus 0.0023 0.003 0.001
Echinococcus granulosus dna polymerase eta 0.0021 0.0021 0.0018
Echinococcus granulosus dna polymerase kappa 0.0021 0.0021 0.0018
Schistosoma mansoni hypothetical protein 0.0033 0.0072 0.0068
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0059 0.0188 0.0201
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0186 0.0747 0.3878
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0059 0.0188 0.0201
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0189 0.0761 0.0824
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.1059 0.5015
Schistosoma mansoni thyroid hormone receptor 0.0189 0.0761 0.0757
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0187 0.0183
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0189 0.0761 0.0757
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0059 0.0188 0.0963
Brugia malayi Histone deacetylase family protein 0.0452 0.192 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0007 0.0017
Loa Loa (eye worm) DR-78 0.0089 0.0321 0.1653
Loa Loa (eye worm) hypothetical protein 0.0262 0.1081 0.5618
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Brugia malayi glutathione reductase 0.0037 0.0092 0.0462
Onchocerca volvulus Glucosylceramidase homolog 0.0169 0.067 0.3092
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0037 0.0171
Giardia lamblia Kinase, PLK 0.0186 0.0747 0.421
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.071 0.3351
Brugia malayi nuclear hormone receptor 0.0089 0.0321 0.1653
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.067 0.3161
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0417 0.1765 0.8381
Schistosoma mansoni RAR-like nuclear receptor 0.0189 0.0761 0.0757
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0185 0.0742 0.3852
Brugia malayi Cation transporter family protein 0.0059 0.0188 0.0963
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0021 0.0088
Loa Loa (eye worm) BRM protein 0.0038 0.0095 0.0475
Echinococcus granulosus global transcription activator snf2l2 0.0073 0.0251 0.0269
Loa Loa (eye worm) acetylcholine receptor protein 0.0023 0.0028 0.0125
Loa Loa (eye worm) hypothetical protein 0.0189 0.0761 0.3948
Loa Loa (eye worm) hypothetical protein 0.0052 0.0158 0.0802
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0007 0.0017
Schistosoma mansoni nAChR subunit 0.0059 0.0188 0.0185
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0059 0.0188 0.0201
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.0108 0.0404 0.04
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0189 0.0761 0.3948
Entamoeba histolytica Flap nuclease, putative 0.0028 0.0053 0.0262
Loa Loa (eye worm) hypothetical protein 0.0139 0.0541 0.2802
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0004 0.0002
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0059 0.0188 0.0963
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0089 0.0321 0.141
Echinococcus granulosus glycine receptor subunit alpha 1 0.0059 0.0188 0.0201
Schistosoma mansoni glutaminase 0.0265 0.1094 0.1091
Echinococcus multilocularis GPCR, family 2 0.0033 0.0072 0.0074
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0007 0.0017
Brugia malayi Pre-SET motif family protein 0.0434 0.184 0.9581
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.003 0.013
Loa Loa (eye worm) matrixin family protein 0.0253 0.1044 0.5428
Brugia malayi RNA recognition motif domain containing protein 0.0123 0.0471 0.2436
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Trypanosoma cruzi polo-like protein kinase, putative 0.0186 0.0747 0.3878
Entamoeba histolytica hypothetical protein 0.0036 0.0085 0.0446
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.01 0.0368 0.0396
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0036 0.0088 0.0085
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0059 0.0188 0.0201
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0059 0.0188 0.0201
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0092 0.1245
Onchocerca volvulus Serine\/threonine kinase homolog 0.0186 0.0747 0.3464
Loa Loa (eye worm) glutathione reductase 0.0037 0.0092 0.0462
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0189 0.0761 0.0824
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0059 0.0188 0.0963
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0072 0.0074
Echinococcus granulosus muscleblind protein 0.0163 0.0646 0.0699
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.071 0.3351
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0059 0.0188 0.0185
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0189 0.0761 0.3948
Onchocerca volvulus 0.0162 0.0641 0.2955
Onchocerca volvulus Matrilysin homolog 0.0253 0.1044 0.4894
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0111 0.0497
Onchocerca volvulus Fxna peptidase homolog 0.0042 0.0111 0.0402
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0185 0.0742 0.0738
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.0303 0.4084
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.003 0.0237
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0036 0.0088 0.0441
Schistosoma mansoni nuclear hormone receptor 0.0189 0.0761 0.0757
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0189 0.0761 0.0824
Loa Loa (eye worm) hypothetical protein 0.0086 0.0307 0.158
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0189 0.0761 0.3948
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0059 0.0188 0.0201
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0189 0.0761 0.3948
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0185 0.0742 0.4181
Echinococcus multilocularis endoplasmic reticulum metallopeptidase 1 0.0042 0.0111 0.0117
Plasmodium vivax histone deacetylase 1, putative 0.0417 0.1765 0.9188
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0238 0.1224
Giardia lamblia Flap structure-specific endonuclease 0.0028 0.0053 0.0262
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0007 0.0017
Schistosoma mansoni nuclear receptor 0.0089 0.0321 0.0317
Schistosoma mansoni nAChR subunit 0.0059 0.0188 0.0185
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0087 0.0311 0.1604
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0189 0.0761 0.3948
Onchocerca volvulus 0.0059 0.0188 0.0773
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0004 0.0056
Onchocerca volvulus Protein ultraspiracle homolog 0.0189 0.0761 0.3529
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0187 0.2519
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.01 0.0368 0.0396
Echinococcus multilocularis histone deacetylase 3 0.0417 0.1765 0.1917
Trichomonas vaginalis histone deacetylase, putative 0.0417 0.1765 0.8381
Brugia malayi steroid hormone receptor 0.0189 0.0761 0.3948
Schistosoma mansoni nicalin (M28 family) 0.0042 0.0111 0.0107
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0059 0.0188 0.0201
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0059 0.0188 0.0201
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0189 0.0761 0.3948
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0007 0.0017
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Schistosoma mansoni histone deacetylase hda2 0.046 0.1953 0.195
Onchocerca volvulus 0.0189 0.0761 0.3529
Loa Loa (eye worm) hypothetical protein 0.0033 0.0072 0.0354
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0007 0.0018
Onchocerca volvulus 0.0059 0.0188 0.0773
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0031 0.0029
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Brugia malayi hypothetical protein 0.0052 0.0158 0.0802
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Loa Loa (eye worm) hypothetical protein 0.0163 0.0646 0.3352
Loa Loa (eye worm) matrixin family protein 0.0276 0.1145 0.5953
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0192 0.0205
Echinococcus multilocularis neuropeptide s receptor 0.0517 0.2206 0.2397
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0023 0.0028 0.0026
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0059 0.0188 0.0185
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.0303 0.4084
Treponema pallidum ATP-dependent RNA helicase 0.0185 0.0742 0.5
Schistosoma mansoni hypothetical protein 0.0033 0.0072 0.0068
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0059 0.0188 0.0201
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Schistosoma mansoni NAALADASE L peptidase (M28 family) 0.0042 0.0111 0.0107
Brugia malayi hypothetical protein 0.0023 0.0028 0.0125
Brugia malayi Matrixin family protein 0.0276 0.1145 0.5953
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0189 0.0761 0.0824
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0023 0.0028 0.0125
Onchocerca volvulus Matrix metalloproteinase homolog 0.0253 0.1044 0.4894
Schistosoma mansoni Fxna peptidase (M28 family) 0.0042 0.0111 0.0107
Onchocerca volvulus 0.0148 0.0578 0.2651
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0441
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0059 0.0188 0.0201
Echinococcus granulosus FTZ F1 alpha 0.0189 0.0761 0.0824
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0021 0.0088
Brugia malayi hypothetical protein 0.0023 0.0028 0.0125
Loa Loa (eye worm) hypothetical protein 0.01 0.0368 0.1899
Schistosoma mansoni neurotransmitter gated ion channel 0.0036 0.0088 0.0085
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0021 0.0279
Mycobacterium tuberculosis Probable oxidoreductase 0.0095 0.0345 0.4648
Onchocerca volvulus Histone deacetylase 10 homolog 0.0197 0.0797 0.3704
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.003 0.0404
Plasmodium falciparum eukaryotic initiation factor 4A 0.0185 0.0742 0.3852
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0185 0.0742 0.3439
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0036 0.0088 0.0441
Loa Loa (eye worm) hypothetical protein 0.0103 0.0382 0.1974
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0189 0.0761 0.0757
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0023 0.0028 0.0125
Echinococcus multilocularis thyroid hormone receptor alpha 0.0189 0.0761 0.0824
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0141 0.0137
Loa Loa (eye worm) hypothetical protein 0.0189 0.0761 0.3948
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.0382 0.1974
Echinococcus multilocularis histone deacetylase 8 0.0197 0.0797 0.0863
Brugia malayi Muscleblind-like protein 0.0163 0.0646 0.3352
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0021 0.0088
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0202 0.0216
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0189 0.0761 0.0757
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0037 0.0036
Onchocerca volvulus Bile acid receptor homolog 0.0189 0.0761 0.3529
Brugia malayi glutaminase DH11.1 0.0265 0.1094 0.5688
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0031 0.0029
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Leishmania major histone deacetylase, putative 0.0417 0.1765 0.9188
Loa Loa (eye worm) glutaminase 0.0265 0.1094 0.5688
Brugia malayi nuclear receptor NHR-88 0.0089 0.0321 0.1653
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0186 0.0747 0.0809
Schistosoma mansoni kinase 0.0095 0.0345 0.0341
Trypanosoma brucei histone deacetylase 2 0.0197 0.0797 0.4139
Brugia malayi Nuclear hormone receptor-like 1 0.01 0.0368 0.1899
Loa Loa (eye worm) histone deacetylase 3 0.0417 0.1765 0.9188
Mycobacterium ulcerans glutaminase 0.0265 0.1094 1
Loa Loa (eye worm) histone deacetylase 7A 0.0452 0.192 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0002
Echinococcus multilocularis histone deacetylase 6 0.046 0.1953 0.2122
Loa Loa (eye worm) nuclear receptor NHR-67 0.0089 0.0321 0.1653
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.0502 0.2599
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0416 0.1758 0.1909
Brugia malayi hypothetical protein 0.0089 0.0321 0.1653
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.0747 0.3529
Brugia malayi conserved hypotetical protein 0.0089 0.0321 0.1653
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0189 0.0761 0.3948
Loa Loa (eye worm) hypothetical protein 0.0263 0.1084 0.5636
Loa Loa (eye worm) LGC-31 protein 0.0059 0.0188 0.0963
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0215 0.1101
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.0185 0.0742 0.3852
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Leishmania major trypanothione reductase 0.0037 0.0092 0.0462
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0189 0.0761 0.3948
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0002
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0059 0.0188 0.0963
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.0747 0.3529
Brugia malayi Nuclear hormone receptor E75 0.0089 0.0321 0.1653
Loa Loa (eye worm) hypothetical protein 0.0042 0.0111 0.0561
Loa Loa (eye worm) hypothetical protein 0.0062 0.0202 0.1035
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0059 0.0188 0.0963
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.003 0.0237
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0021 0.0088
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0441
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0021 0.0065
Trypanosoma brucei unspecified product 0.0021 0.0021 0.0088
Trypanosoma cruzi histone deacetylase 1, putative 0.0417 0.1765 0.9188
Echinococcus multilocularis histone deacetylase 6 0.0452 0.192 0.2086
Echinococcus granulosus endoplasmic reticulum metallopeptidase 1 0.0042 0.0111 0.0117
Brugia malayi Hemopexin family protein 0.0162 0.0641 0.3327
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0059 0.0188 0.0963
Mycobacterium tuberculosis Probable reductase 0.0085 0.0303 0.4084
Echinococcus granulosus ecdysone induced protein 78C 0.0189 0.0761 0.0824
Echinococcus multilocularis nAChR subunit 0.0036 0.0088 0.0092
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0441
Schistosoma mansoni nAChR subunit 0.0059 0.0188 0.0185
Echinococcus multilocularis tar DNA binding protein 0.0123 0.0471 0.0508
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0085 0.0082
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0471 0.0467
Trypanosoma cruzi histone deacetylase, putative 0.0452 0.192 1
Schistosoma mansoni histone deacetylase 0.0417 0.1765 0.1762
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0023 0.003 0.0136
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0023 0.0028 0.0026
Trypanosoma cruzi histone deacetylase, putative 0.0452 0.192 1
Schistosoma mansoni nAChR subunit 0.0059 0.0188 0.0185
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Schistosoma mansoni serine/threonine protein kinase 0.0186 0.0747 0.0744
Onchocerca volvulus 0.0059 0.0188 0.0773
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.003 0.013
Loa Loa (eye worm) hypothetical protein 0.0021 0.0021 0.0092
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0072 0.0074
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0021 0.0279
Loa Loa (eye worm) hypothetical protein 0.0042 0.0111 0.0561
Brugia malayi hypothetical protein 0.01 0.0368 0.1899
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0059 0.0188 0.0185
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0089 0.0321 0.141
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0092 0.0462
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0089 0.0321 0.1653
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0189 0.0761 0.0824
Loa Loa (eye worm) histone deacetylase 0.0452 0.192 1
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0053 0.0219
Mycobacterium tuberculosis Conserved protein 0.0042 0.0111 0.15
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0471 0.0467
Plasmodium vivax histone deacetylase 2, putative 0.0452 0.192 1
Loa Loa (eye worm) histone deacetylase 11 0.0197 0.0797 0.4139
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0059 0.0188 0.0963
Brugia malayi histone deacetylase 1 (HD1) 0.0417 0.1765 0.9188
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0257 0.1059 0.5505
Loa Loa (eye worm) hypothetical protein 0.0114 0.0431 0.223
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Leishmania major histone deacetylase, putative 0.0417 0.1765 0.9188
Schistosoma mansoni nuclear receptor 0.0089 0.0321 0.0317
Brugia malayi nuclear receptor RXR 0.0089 0.0321 0.1653
Echinococcus granulosus nAChR subunit 0.0036 0.0088 0.0092
Brugia malayi Pre-SET motif family protein 0.0062 0.0202 0.1035
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0021 0.0017
Brugia malayi Thioredoxin reductase 0.0037 0.0092 0.0462
Trypanosoma cruzi histone deacetylase, putative 0.0197 0.0797 0.4139
Schistosoma mansoni zinc finger protein 0.0089 0.0321 0.0317
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Plasmodium falciparum histone deacetylase 1 0.0417 0.1765 0.9188
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0053 0.0054
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0215 0.1182
Brugia malayi hypothetical protein 0.0023 0.0028 0.0125
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0059 0.0188 0.0963
Schistosoma mansoni hypothetical protein 0.0033 0.0072 0.0068
Echinococcus granulosus histone deacetylase 6 0.0452 0.192 0.2086
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0202 0.0216
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0187 0.1677
Wolbachia endosymbiont of Brugia malayi extracellular metallopeptidase 0.0898 0.388 0.5
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0185 0.0742 0.0738
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0187 0.0955
Echinococcus granulosus neuropeptide s receptor 0.0517 0.2206 0.2397
Loa Loa (eye worm) hypothetical protein 0.0042 0.0111 0.0561
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0007 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0189 0.0761 0.3948
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0095 0.0099
Echinococcus granulosus glycine receptor subunit beta 0.0059 0.0188 0.0201
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0007 0.0018
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0094 0.0098
Echinococcus multilocularis dual specificity 0.0087 0.0311 0.0335
Trichomonas vaginalis histone deacetylase, putative 0.0417 0.1765 0.8381
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0441
Entamoeba histolytica protein kinase, putative 0.0087 0.0311 0.1731
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.003 0.0237
Schistosoma mansoni nuclear hormone receptor 0.0089 0.0321 0.0317
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0059 0.0188 0.0201
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0085 0.0089
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0185 0.0742 0.3504
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0059 0.0188 0.0963
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0089 0.0321 0.0345
Mycobacterium ulcerans lipoprotein aminopeptidase LpqL 0.0042 0.0111 0.0983
Entamoeba histolytica histone deacetylase, putative 0.0417 0.1765 1
Trypanosoma cruzi histone deacetylase, putative 0.0452 0.192 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0215 0.1101
Loa Loa (eye worm) hypothetical protein 0.0197 0.0797 0.4139
Brugia malayi Peptidase family M28 containing protein 0.0262 0.1081 0.5618
Onchocerca volvulus Glutaminyl cyclase homolog 0.0262 0.1081 0.507
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0021 0.0018
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0189 0.0761 0.0824
Echinococcus granulosus Nuclear hormone receptor HR96 0.0089 0.0321 0.0345
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0053 0.0257
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0087 0.0311 0.1604
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0023 0.0028 0.0026
Echinococcus granulosus tar DNA binding protein 0.0123 0.0471 0.0508
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0123 0.0471 0.2436
Echinococcus multilocularis nuclear receptor nhr 48 0.0089 0.0321 0.0345
Entamoeba histolytica protein kinase domain containing protein 0.0087 0.0311 0.1731
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0007 0.0017
Onchocerca volvulus Fxna peptidase homolog 0.0042 0.0111 0.0402
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.0747 0.3529
Echinococcus multilocularis n acetylated alpha linked acidic dipeptidase 2 0.0042 0.0111 0.0117
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0007 0.0017
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0471 0.0467
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0185 0.0742 0.3504
Schistosoma mansoni nAChR subunit 0.0059 0.0188 0.0185
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0059 0.0188 0.0201
Loa Loa (eye worm) hypothetical protein 0.0048 0.0141 0.0714
Brugia malayi hypothetical protein 0.0023 0.0028 0.0125
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Schistosoma mansoni nAChR subunit 0.0059 0.0188 0.0185
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0158 0.0802
Leishmania major hypothetical protein, conserved 0.0052 0.0158 0.0802
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0187 0.0199
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0053 0.0257
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0028 0.0125
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0095 0.0345 0.6164
Plasmodium falciparum glutathione reductase 0.0037 0.0092 0.0462
Brugia malayi Matrixin family protein 0.0114 0.0431 0.223
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Onchocerca volvulus 0.0089 0.0321 0.141
Schistosoma mansoni histone deacetylase hda2 0.0197 0.0797 0.0793
Loa Loa (eye worm) hypothetical protein 0.0255 0.1051 0.5465
Loa Loa (eye worm) BRM protein 0.0047 0.0134 0.068
Schistosoma mansoni nAChR subunit 0.0023 0.0028 0.0024
Brugia malayi Histone deacetylase family protein 0.0452 0.192 1
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0059 0.0188 0.0201
Onchocerca volvulus 0.0059 0.0188 0.0773
Schistosoma mansoni acetylcholine receptor-related 0.0023 0.0028 0.0024
Echinococcus multilocularis histone deacetylase 1 0.0417 0.1765 0.1917
Echinococcus multilocularis muscleblind protein 1 0.0163 0.0646 0.0699
Plasmodium vivax histone deacetylase, putative 0.0197 0.0797 0.4139
Trypanosoma brucei histone deacetylase 4 0.0452 0.192 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0007 0.0017
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0187 0.1677
Brugia malayi hypothetical protein 0.0148 0.0578 0.2998
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0059 0.0188 0.0201
Loa Loa (eye worm) hypothetical protein 0.0114 0.0431 0.223
Schistosoma mansoni flap endonuclease-1 0.0026 0.0041 0.0037
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0215 0.023
Echinococcus multilocularis histone deacetylase 7 0.0452 0.192 0.2086
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0185 0.0742 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0189 0.0761 0.3948
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0185 0.0742 0.3504
Echinococcus multilocularis dna polymerase eta 0.0021 0.0021 0.0018
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0007 0.0017
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0072 0.0354
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0053 0.0257
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0215 0.1101
Brugia malayi excitatory GABA receptor EXP-1A 0.0059 0.0188 0.0963
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0215 0.1101
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0441
Brugia malayi Histone deacetylase 1 0.0417 0.1765 0.9188
Echinococcus multilocularis microtubule associated protein 2 0.2103 0.919 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0072 0.0074
Schistosoma mansoni nuclear receptor nhr-48 0.0089 0.0321 0.0317
Trypanosoma cruzi histone deacetylase 1, putative 0.0417 0.1765 0.9188
Loa Loa (eye worm) hypothetical protein 0.0163 0.0646 0.3352
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0471 0.0467
Brugia malayi nuclear hormone receptor family member nhr-6 0.0089 0.0321 0.1653
Echinococcus multilocularis FTZ F1 alpha 0.0189 0.0761 0.0824
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0089 0.0321 0.0345
Loa Loa (eye worm) hypothetical protein 0.0234 0.0956 0.4969
Echinococcus granulosus histone deacetylase 0.0452 0.192 0.2086
Brugia malayi Matrixin family protein 0.0114 0.0431 0.223
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Brugia malayi nuclear receptor NHR-88 0.0189 0.0761 0.3948
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0021 0.0077
Brugia malayi Matrixin family protein 0.0114 0.0431 0.223
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0185 0.0742 0.0804
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0185 0.0742 0.3852
Echinococcus granulosus histone deacetylase 6 0.0452 0.192 0.2086
Echinococcus granulosus endoplasmic reticulum metallopeptidase 1 0.0042 0.0111 0.0117
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0037 0.0036
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0189 0.0761 0.0824
Loa Loa (eye worm) hypothetical protein 0.0189 0.0761 0.3948
Trypanosoma brucei glutaminyl cyclase, putative 0.0042 0.0111 0.0561
Echinococcus multilocularis tumor protein p63 0.033 0.1383 0.1501
Onchocerca volvulus 0.0494 0.2104 1
Plasmodium vivax histone deacetylase, putative 0.0452 0.192 1
Loa Loa (eye worm) glutaminase 2 0.0265 0.1094 0.5688
Echinococcus multilocularis glutaminyl peptide cyclotransferase 0.0262 0.1081 0.1172
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0072 0.0074
Echinococcus multilocularis glycine receptor subunit beta 0.0059 0.0188 0.0201
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0021 0.0018
Schistosoma mansoni hypothetical protein 0.0164 0.0651 0.0647
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0186 0.0747 0.3878
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.003 0.0404
Trichomonas vaginalis histone deacetylase, putative 0.0417 0.1765 0.8381
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0021 0.0018
Loa Loa (eye worm) hypothetical protein 0.01 0.0368 0.1899
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0189 0.0761 0.3948
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0417 0.1765 0.8381
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0021 0.0017
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0434 0.184 0.9581
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0059 0.0188 0.0185
Schistosoma mansoni steroid hormone receptor ad4bp 0.0189 0.0761 0.0757
Brugia malayi histone deacetylase 11 0.0197 0.0797 0.4139
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0059 0.0188 0.0963
Schistosoma mansoni nuclear hormone receptor 0.0089 0.0321 0.0317
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.067 0.3161
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0189 0.0761 0.0824
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0059 0.0188 0.0963
Loa Loa (eye worm) hypothetical protein 0.01 0.0368 0.1899
Giardia lamblia DINP protein human, muc B family 0.0021 0.0021 0.0077
Entamoeba histolytica hypothetical protein 0.0036 0.0085 0.0446
Leishmania major histone deacetylase, putative 0.0452 0.192 1
Onchocerca volvulus 0.0036 0.0088 0.0292
Brugia malayi AMP-binding enzyme family protein 0.0023 0.003 0.0136
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0158 0.0802
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0139 0.0541 0.7289
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0007 0.0017
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0185 0.0742 0.0804
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Echinococcus multilocularis neuropeptide receptor A26 0.0517 0.2206 0.2397
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0186 0.0747 0.0809
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.067 0.3161
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0471 0.0467
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Loa Loa (eye worm) leucyl aminopeptidase 0.0042 0.0111 0.0561
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0185 0.0742 0.4181
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0037 0.0141
Schistosoma mansoni coup transcription factor 0.0189 0.0761 0.0757
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0007 0.0017
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.01 0.0368 0.1899
Leishmania major DNA polymerase eta, putative 0.0021 0.0021 0.0088
Loa Loa (eye worm) nuclear hormone receptor 0.0089 0.0321 0.1653
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0023 0.0028 0.0125
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0185 0.0742 0.0804
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0089 0.0321 0.0345
Loa Loa (eye worm) steroid hormone receptor 0.0189 0.0761 0.3948
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0059 0.0188 0.0963
Echinococcus multilocularis histone deacetylase 0.0452 0.192 0.2086
Toxoplasma gondii hypothetical protein 0.0042 0.0111 0.0561
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0021 0.0088
Brugia malayi TAR-binding protein 0.0123 0.0471 0.2436
Toxoplasma gondii histone deacetylase HDAC5 0.0197 0.0797 0.4139
Echinococcus granulosus geminin 0.0164 0.0651 0.0704
Entamoeba histolytica hypothetical protein 0.0036 0.0085 0.0446
Onchocerca volvulus 0.0048 0.0141 0.0544
Schistosoma mansoni histone deacetylase 0.0417 0.1765 0.1762
Brugia malayi ecdysone receptor 0.0089 0.0321 0.1653
Brugia malayi nuclear hormone receptor 0.0189 0.0761 0.3948
Echinococcus granulosus flap endonuclease 1 0.0028 0.0053 0.0054
Schistosoma mansoni hypothetical protein 0.0071 0.0238 0.0235
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0187 0.1677
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0416 0.1758 0.1909
Mycobacterium tuberculosis Probable lipoprotein aminopeptidase LpqL 0.0042 0.0111 0.15
Echinococcus granulosus microtubule associated protein 2 0.2103 0.919 1
Brugia malayi hypothetical protein 0.0023 0.0028 0.0125
Loa Loa (eye worm) hypothetical protein 0.0086 0.0307 0.158

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 0.36 ng ml-1 Compound was evaluated for the inhibition of cell growth in mouse P-815 mastocytoma cells. ChEMBL. 3806605
IC50 (functional) = 3 ng ml-1 Compound was evaluated for the inhibition of Con A (concanavalin A) stimulated murine thymocyte mitogenesis. ChEMBL. 3806605

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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