Detailed information for compound 307486

Basic information

Technical information
  • TDR Targets ID: 307486
  • Name: 1-oxo-2-[2-oxo-2-[(1,1,1-trifluoro-4-methyl-2 -oxopentan-3-yl)amino]ethyl]-4,9-dihydro-3H-p yrido[3,4-b]indole-8-carboxylic acid
  • MW: 439.385 | Formula: C20H20F3N3O5
  • H donors: 3 H acceptors: 5 LogP: 2.98 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CN1CCc2c(C1=O)[nH]c1c2cccc1C(=O)O)NC(C(=O)C(F)(F)F)C(C)C
  • InChi: 1S/C20H20F3N3O5/c1-9(2)14(17(28)20(21,22)23)24-13(27)8-26-7-6-11-10-4-3-5-12(19(30)31)15(10)25-16(11)18(26)29/h3-5,9,14,25H,6-8H2,1-2H3,(H,24,27)(H,30,31)
  • InChiKey: GDDHWJRVOJSAHA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-oxo-2-[2-oxo-2-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propyl)amino]ethyl]-4,9-dihydro-3H-pyrido[3,4-b]indole-8-carboxylic acid
  • 1-oxo-2-[2-oxo-2-[(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)amino]ethyl]-4,9-dihydro-3H-pyrido[3,4-b]indole-8-carboxylic acid
  • 1-oxo-2-[2-oxo-2-[(1,1,1-trifluoro-4-methyl-2-oxo-pentan-3-yl)amino]ethyl]-4,9-dihydro-3H-pyrido[3,4-b]indole-8-carboxylic acid
  • 1-keto-2-[2-keto-2-[(3,3,3-trifluoro-1-isopropyl-2-keto-propyl)amino]ethyl]-4,9-dihydro-3H-$b-carboline-8-carboxylic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens elastase, neutrophil expressed Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus transmembrane protease serine 3 elastase, neutrophil expressed 267 aa 236 aa 27.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major heat shock protein 83-1 0.0066 0.083 1
Plasmodium vivax DNA topoisomerase II, putative 0.0013 0.007 0.0846
Leishmania major heat shock protein 83-1 0.0066 0.083 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0053
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0366 0.0797
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0013 0.007 1
Mycobacterium ulcerans two component regulator - sensor kinase 0.0013 0.007 0.1105
Echinococcus multilocularis microtubule associated protein 2 0.0698 1 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0159 0.0159
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0013 0.007 0.1105
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0052 0.0635 0.0635
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0013 0.007 0.1105
Plasmodium falciparum heat shock protein 90, putative 0.0027 0.0267 0.3215
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0024 0.0053
Echinococcus multilocularis caspase 3 0.0147 0.201 0.201
Loa Loa (eye worm) hypothetical protein 0.002 0.016 0.0348
Trypanosoma brucei metacaspase 5, putative 0.0054 0.0655 0.7892
Echinococcus multilocularis lamin dm0 0.0027 0.0272 0.0272
Loa Loa (eye worm) histone methyltransferase 0.001 0.0022 0.0049
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0354 0.4273
Leishmania major DNA polymerase kappa, putative 0.002 0.0159 0.1918
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0027 0.0267 0.3215
Onchocerca volvulus 0.0029 0.0297 0.0885
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0024 0.0024
Trypanosoma cruzi metacaspase, putative 0.0054 0.0655 0.7892
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0024 0.0024
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0117 0.1575 0.1575
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0159 0.0159
Onchocerca volvulus 0.002 0.016 0.0476
Brugia malayi tumor suppressor. 0.0325 0.4594 1
Brugia malayi CXXC zinc finger family protein 0.0029 0.0297 0.0647
Trypanosoma brucei Metacaspase-4 0.0054 0.0655 0.7892
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0404 0.0404
Schistosoma mansoni coup transcription factor 0.001 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0013 0.007 0.0153
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0024 0.0072
Echinococcus multilocularis dna polymerase eta 0.0045 0.0533 0.0533
Onchocerca volvulus 0.0027 0.0272 0.0808
Trypanosoma brucei heat shock protein, putative 0.0066 0.083 1
Echinococcus multilocularis lamin 0.0027 0.0272 0.0272
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0323 0.0323
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.016 0.016
Giardia lamblia Grp94/Hsp90 0.0052 0.0635 0.7659
Echinococcus multilocularis heat shock protein 0.0066 0.083 0.083
Trypanosoma cruzi heat shock protein 85, putative 0.0066 0.083 1
Plasmodium falciparum endoplasmin, putative 0.004 0.0461 0.5556
Trypanosoma brucei heat shock protein 90, putative 0.0066 0.083 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0655 0.1949
Loa Loa (eye worm) tumor suppressor 0.0325 0.4594 1
Brugia malayi Pre-SET motif family protein 0.0211 0.2939 0.6396
Plasmodium falciparum heat shock protein 90 0.0066 0.083 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0024 0.0024
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0108 0.0108
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0054 0.0655 0.0655
Entamoeba histolytica heat shock protein 90, putative 0.0066 0.083 1
Trypanosoma cruzi heat shock protein 85, putative 0.0052 0.0635 0.7659
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0013 0.007 0.0209
Echinococcus granulosus heat shock protein 0.0066 0.083 0.083
Onchocerca volvulus 0.0027 0.0272 0.0808
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0323 0.3895
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0159 0.0474
Schistosoma mansoni rotamase 0.0034 0.0366 0.0366
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0024 0.0024
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.016 0.016
Trypanosoma cruzi metacaspase, putative 0.0054 0.0655 0.7892
Trichomonas vaginalis heat shock protein, putative 0.0066 0.083 0.2469
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0013 0.007 0.0209
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0024 0.0053
Toxoplasma gondii heat shock protein 90, putative 0.0066 0.083 1
Brugia malayi Probable DNA topoisomerase II 0.0013 0.007 0.0153
Schistosoma mansoni microtubule-associated protein tau 0.0698 1 1
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0272 0.0591
Loa Loa (eye worm) doublecortin family protein 0.002 0.016 0.0348
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0071 0.0859
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0159 0.1918
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0024 0.0053
Echinococcus granulosus protein quaking 0.0028 0.0275 0.0275
Mycobacterium ulcerans two component sensor kinase MprB 0.0013 0.007 0.1105
Entamoeba histolytica hypothetical protein 0.0036 0.0404 0.4867
Brugia malayi hypothetical protein 0.0239 0.3345 0.7282
Loa Loa (eye worm) hypothetical protein 0.0027 0.0264 0.0576
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0013 0.007 0.0846
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0024 0.0053
Echinococcus multilocularis survival motor neuron protein 1 0.0239 0.3345 0.3345
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0025 0.0301
Trypanosoma cruzi heat shock protein 90, putative 0.0066 0.083 1
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0272 0.0591
Echinococcus multilocularis caspase 8 0.0054 0.0655 0.0655
Echinococcus granulosus caspase 0.0201 0.2789 0.2789
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0159 0.1918
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0021 0.0045
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0108 0.1299
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0159 0.1918
Brugia malayi isocitrate dehydrogenase 0.0016 0.0108 0.0235
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0013 0.007 0.1105
Trypanosoma cruzi metacaspase, putative 0.0054 0.0655 0.7892
Plasmodium vivax metacaspase 1, putative 0.0054 0.0655 0.7892
Brugia malayi Pre-SET motif family protein 0.0031 0.0323 0.0703
Loa Loa (eye worm) hypothetical protein 0.0028 0.0275 0.0599
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0024 0.0053
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0159 0.0159
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0024 0.0024
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0013 0.007 0.1105
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0108 0.1299
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.016 0.016
Onchocerca volvulus 0.002 0.016 0.0476
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0013 0.007 0.0846
Plasmodium vivax DNA gyrase subunit B, putative 0.0013 0.007 0.0846
Plasmodium vivax hypothetical protein, conserved 0.0013 0.007 0.0846
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0297 0.0647
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0024 0.0053
Brugia malayi steroid hormone receptor 0.001 0.0024 0.0053
Schistosoma mansoni eyes absent homolog 0.0089 0.1169 0.1169
Giardia lamblia Pms1-like protein 0.0013 0.007 0.0846
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0108 0.0108
Leishmania major heat shock protein 83-1 0.0066 0.083 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.069 0.8321
Loa Loa (eye worm) hypothetical protein 0.0054 0.0655 0.1425
Brugia malayi Cell death protein 3 precursor 0.0054 0.0655 0.1425
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0655 0.1949
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0053
Trypanosoma brucei heat shock protein 90, putative 0.0066 0.083 1
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0013 0.007 0.1105
Toxoplasma gondii DNA topoisomerase 2, putative 0.0013 0.007 0.0846
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0013 0.007 0.0846
Schistosoma mansoni hypothetical protein 0.0028 0.0275 0.0275
Echinococcus multilocularis dnaJ subfamily B 0.0414 0.5877 0.5877
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0013 0.007 0.0209
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0053
Echinococcus granulosus tumor protein p63 0.0342 0.4833 0.4833
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0655 0.1949
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0071 0.0859
Plasmodium vivax heat shock protein 86, putative 0.0066 0.083 1
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0655 0.1949
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0108 0.1696
Schistosoma mansoni pyruvate dehydrogenase 0.0013 0.007 0.007
Chlamydia trachomatis DNA gyrase subunit B 0.0013 0.007 1
Leishmania major developmentally regulated phosphoprotein-like protein 0.0013 0.007 0.0846
Toxoplasma gondii heat shock protein HSP90 0.0066 0.083 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0024 0.0053
Schistosoma mansoni hypothetical protein 0.0036 0.0404 0.0404
Echinococcus granulosus caspase 3 0.0147 0.201 0.201
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0024 0.0053
Plasmodium vivax endoplasmin, putative 0.0066 0.083 1
Schistosoma mansoni caspase-7 (C14 family) 0.0201 0.2789 0.2789
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0159 0.1918
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0054 0.0655 0.7892
Trypanosoma brucei metacaspase 0.0054 0.0655 0.7892
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0159 0.1918
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0013 0.007 0.1105
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0013 0.007 0.0846
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0024 0.0053
Trypanosoma brucei heat shock protein, putative 0.0066 0.083 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0024 0.0024
Trichomonas vaginalis sensor histidine kinase, putative 0.0013 0.007 0.0209
Echinococcus granulosus RUN 0.002 0.016 0.016
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0088 0.0191
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0013 0.007 0.1105
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.2939 0.6396
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0024 0.0053
Brugia malayi nuclear receptor NHR-88 0.001 0.0024 0.0053
Schistosoma mansoni cpg binding protein 0.0031 0.0321 0.0321
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0052 0.0635 1
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0024 0.0053
Plasmodium falciparum DNA topoisomerase 2 0.0013 0.007 0.0846
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0024 0.0024
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0159 0.2504
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0159 0.2504
Leishmania major heat shock protein 83-1 0.0066 0.083 1
Schistosoma mansoni lipoxygenase 0.0117 0.1575 0.1575
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0013 0.0067 0.0146
Trypanosoma cruzi heat shock protein 85, putative 0.0066 0.083 1
Brugia malayi kinase, mitochondrial precursor 0.0013 0.007 0.0153
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0027 0.0267 0.0267
Loa Loa (eye worm) hypothetical protein 0.0089 0.1169 0.2544
Echinococcus multilocularis cpg binding protein 0.0031 0.0321 0.0321
Loa Loa (eye worm) hypothetical protein 0.0045 0.0533 0.116
Mycobacterium tuberculosis Possible two component sensor kinase 0.0013 0.007 0.1105
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0013 0.007 0.007
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0024 0.0072
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0786 0.0786
Echinococcus multilocularis protein quaking 0.0028 0.0275 0.0275
Trichomonas vaginalis heat shock protein, putative 0.0052 0.0635 0.1891
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0053
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0338 0.4069
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0108 0.1299
Leishmania major heat shock protein 83-1 0.0066 0.083 1
Trypanosoma brucei unspecified product 0.002 0.0159 0.1918
Leishmania major heat shock protein 83-1 0.0066 0.083 1
Schistosoma mansoni caspase-3 (C14 family) 0.0201 0.2789 0.2789
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0108 0.1299
Echinococcus granulosus survival motor neuron protein 1 0.0239 0.3345 0.3345
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0159 0.1918
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0013 0.007 0.1105
Trypanosoma brucei Heat shock protein 83, putative 0.0066 0.083 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0655 0.1949
Trypanosoma brucei heat shock protein 84, putative 0.0027 0.0267 0.3215
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0159 0.1918
Treponema pallidum heat shock protein 90 0.0052 0.0635 1
Leishmania major heat shock protein 83-1 0.0066 0.083 1
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0013 0.007 0.0741
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0404 0.0404
Leishmania major heat shock protein 83-1 0.0066 0.083 1
Leishmania major heat shock protein 83-1 0.0066 0.083 1
Trypanosoma cruzi metacaspase 5, putative 0.0054 0.0655 0.7892
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0338 0.4069
Mycobacterium ulcerans putative regultory protein 0.0013 0.007 0.1105
Echinococcus granulosus dna polymerase kappa 0.002 0.0159 0.0159
Plasmodium vivax heat shock protein, putative 0.0027 0.0267 0.3215
Toxoplasma gondii heat shock protein 75, putative 0.0027 0.0267 0.3215
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0366 0.1089
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0584 0.127
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0159 0.1918
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0366 0.0797
Leishmania major heat shock protein 83-1 0.0066 0.083 1
Trichomonas vaginalis heat shock protein, putative 0.004 0.0461 0.1372
Plasmodium falciparum metacaspase-like protein 0.0054 0.0655 0.7892
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.016 0.016
Onchocerca volvulus Cell death protein 3 homolog 0.0054 0.0655 0.1949
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0159 0.0346
Trypanosoma cruzi metacaspase 5, putative 0.0054 0.0655 0.7892
Brugia malayi hypothetical protein 0.002 0.016 0.0348
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0013 0.007 0.0741
Loa Loa (eye worm) endoplasmin 0.0066 0.083 0.1806
Echinococcus granulosus dnaJ subfamily B 0.0414 0.5877 0.5877
Plasmodium vivax heat shock protein 90, putative 0.0027 0.0267 0.3215
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0024 0.0024
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0024 0.0024
Loa Loa (eye worm) heat shock protein 75 0.0027 0.0267 0.0581
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0013 0.007 0.0846
Mycobacterium tuberculosis Conserved protein 0.0013 0.007 0.1105
Trichomonas vaginalis receptor histidine kinase, putative 0.0013 0.007 0.0209
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0024 0.0053
Echinococcus granulosus endoplasmin 0.0052 0.0635 0.0635
Loa Loa (eye worm) hypothetical protein 0.0239 0.3345 0.7282
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0024 0.0024
Trypanosoma brucei heat shock protein, putative 0.0066 0.083 1
Trypanosoma brucei heat shock protein, putative 0.0066 0.083 1
Mycobacterium ulcerans heat shock protein 90 0.0052 0.0635 1
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0013 0.007 0.0209
Echinococcus granulosus dna polymerase eta 0.0045 0.0533 0.0533
Trypanosoma brucei DNA topoisomerase ii 0.0013 0.007 0.0846
Schistosoma mansoni DNA topoisomerase II 0.0013 0.007 0.007
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0024 0.0053
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0013 0.007 0.0846
Brugia malayi nuclear hormone receptor 0.001 0.0024 0.0053
Trichomonas vaginalis endoplasmin, putative 0.004 0.0461 0.1372
Onchocerca volvulus 0.0049 0.0584 0.1737
Schistosoma mansoni rab6-interacting 0.002 0.016 0.016
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0024 0.0024
Onchocerca volvulus 0.0031 0.0323 0.0962
Mycobacterium leprae Probable two component sensor kinase MprB 0.0013 0.007 0.1105
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0655 0.1949
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0013 0.007 0.007
Trichomonas vaginalis rotamase, putative 0.0033 0.0354 0.1055
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0655 0.1949
Leishmania major heat shock protein 83-1 0.0066 0.083 1
Schistosoma mansoni cpg binding protein 0.0029 0.0297 0.0297
Schistosoma mansoni survival motor neuron protein 0.0049 0.0584 0.0584
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0323 0.0323
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0027 0.0267 0.0794
Trichomonas vaginalis heat shock protein, putative 0.0052 0.0635 0.1891
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0024 0.0024
Schistosoma mansoni lamin 0.0027 0.0272 0.0272
Plasmodium vivax hypothetical protein, conserved 0.0054 0.0655 0.7892
Schistosoma mansoni nuclear hormone receptor 0.001 0.0024 0.0024
Echinococcus multilocularis musashi 0.0027 0.0272 0.0272
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0655 0.1949
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0159 0.2504
Schistosoma mansoni caspase-7 (C14 family) 0.0054 0.0655 0.0655
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0354 0.4273
Schistosoma mansoni hypothetical protein 0.002 0.016 0.016
Mycobacterium ulcerans DNA gyrase subunit B 0.0013 0.007 0.1105
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0024 0.0053
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0022 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0024 0.0053
Echinococcus multilocularis RUN 0.002 0.016 0.016
Echinococcus multilocularis endoplasmin 0.0052 0.0635 0.0635
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0013 0.007 0.1105
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0159 0.1918
Leishmania major heat shock protein 83-1 0.0066 0.083 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0108 0.1299
Leishmania major heat shock protein 83-1 0.0066 0.083 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0071 0.0859
Leishmania major heat shock protein, putative 0.0027 0.0267 0.3215
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0053
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0024 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0024 0.0053
Entamoeba histolytica hypothetical protein 0.0036 0.0404 0.4867
Schistosoma mansoni thyroid hormone receptor 0.001 0.0024 0.0024
Loa Loa (eye worm) TOPoisomerase family member 0.0013 0.007 0.0153
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.0439 0.529
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0201 0.2789 0.2789
Echinococcus granulosus FTZ F1 alpha 0.001 0.0024 0.0024
Trichomonas vaginalis rotamase, putative 0.0034 0.0366 0.1089
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0013 0.007 0.007
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0108 0.0108
Plasmodium falciparum heat shock protein 90, putative 0.0027 0.0267 0.3215
Plasmodium vivax SET domain protein, putative 0.0031 0.0323 0.3895
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0267 0.0794
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0655 0.1949
Toxoplasma gondii Hsp90 domain-containing protein 0.0027 0.0267 0.3215
Trypanosoma cruzi heat shock protein 90, putative 0.0052 0.0635 0.7659
Schistosoma mansoni heat shock protein 0.0066 0.083 0.083
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0024 0.0024
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0013 0.007 0.1105
Mycobacterium leprae Probable two-component sensor kinase 0.0013 0.007 0.1105
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0025 0.0301
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0323 0.0323
Trypanosoma cruzi DNA topoisomerase II, putative 0.0013 0.007 0.0846
Entamoeba histolytica hypothetical protein 0.0036 0.0404 0.4867
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0054 0.0655 0.7892
Entamoeba histolytica DNA topoisomerase II, putative 0.0013 0.007 0.0846
Echinococcus multilocularis caspase 0.0201 0.2789 0.2789
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0053
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.001 0.0025 0.0301
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0013 0.007 0.1105
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0013 0.007 0.1105
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0108 0.0108
Echinococcus multilocularis expressed protein 0.0034 0.0366 0.0366
Echinococcus granulosus expressed protein 0.0034 0.0366 0.0366
Schistosoma mansoni cpg binding protein 0.0031 0.0321 0.0321
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0354 0.4273
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0159 0.1918
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0024 0.0053
Leishmania major heat shock protein 83-1 0.0066 0.083 1
Echinococcus multilocularis dna polymerase kappa 0.002 0.0159 0.0159
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0404 0.0404
Loa Loa (eye worm) hypothetical protein 0.0013 0.007 0.0153
Echinococcus multilocularis tumor protein p63 0.0342 0.4833 0.4833
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0108 0.1299
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0272 0.0591
Trypanosoma brucei metacaspase MCA3 0.0054 0.0655 0.7892
Chlamydia trachomatis DNA gyrase subunit B 0.0013 0.007 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0053
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.016 0.016
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0052 0.0635 1
Plasmodium falciparum metacaspase 1 0.0054 0.0655 0.7892
Leishmania major metacaspase, putative 0.0054 0.0655 0.7892
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0013 0.007 0.007
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0354 0.4273
Schistosoma mansoni endoplasmin 0.0066 0.083 0.083
Trypanosoma brucei heat shock protein, putative 0.0066 0.083 1
Schistosoma mansoni DNA polymerase eta 0.0045 0.0533 0.0533
Trypanosoma brucei heat shock protein, putative 0.0066 0.083 1
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0024 0.0053
Echinococcus granulosus caspase 2 0.0054 0.0655 0.0655
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0013 0.007 0.0741
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0013 0.006 0.013
Echinococcus granulosus hypothetical protein 0.0028 0.0275 0.0275
Brugia malayi Doublecortin family protein 0.002 0.016 0.0348
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0013 0.007 0.0209
Echinococcus granulosus caspase 8 0.0054 0.0655 0.0655
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0655 0.1949
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0013 0.007 0.0846
Schistosoma mansoni thyroid hormone receptor 0.001 0.0024 0.0024
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.001 0.0025 0.0301
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.002 0.016 0.0348
Schistosoma mansoni lipoxygenase 0.0082 0.1064 0.1064
Schistosoma mansoni hypothetical protein 0.0414 0.5877 0.5877
Loa Loa (eye worm) hypothetical protein 0.0031 0.0323 0.0703
Trypanosoma brucei heat shock protein, putative 0.0066 0.083 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0159 0.1918
Leishmania major heat shock protein 83-1 0.0066 0.083 1
Trypanosoma cruzi heat shock protein 85, putative 0.0066 0.083 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0159 0.1918
Brugia malayi hypothetical protein 0.0028 0.0275 0.0599
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0159 0.1918
Brugia malayi heat shock protein 90 0.0066 0.083 0.1806
Trichomonas vaginalis set domain proteins, putative 0.024 0.336 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0108 0.0108
Trypanosoma cruzi DNA topoisomerase II, putative 0.0013 0.007 0.0846
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0024 0.0053
Giardia lamblia Heat shock protein HSP 90-alpha 0.0052 0.0635 0.7659
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0024 0.0024
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0022 0.0022
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0108 0.1299
Leishmania major DNA topoisomerase ii 0.0013 0.007 0.0846
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0024 0.0072
Onchocerca volvulus 0.001 0.0024 0.0072
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0024 0.0024
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0013 0.007 0.0209
Echinococcus granulosus cpg binding protein 0.0031 0.0321 0.0321
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0655 0.1949
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0024 0.0053
Loa Loa (eye worm) hypothetical protein 0.0013 0.007 0.0153
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0013 0.007 0.1105
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0013 0.007 0.1105
Brugia malayi Temporarily assigned gene name protein 44 0.0028 0.0275 0.0599
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0159 0.1918
Leishmania major mitochondrial DNA topoisomerase II 0.0013 0.007 0.0846
Onchocerca volvulus 0.024 0.336 1
Trypanosoma brucei metacaspase MCA2 0.0054 0.0655 0.7892
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0108 0.1299
Trypanosoma brucei developmentally regulated phosphoprotein 0.0013 0.007 0.0846
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0013 0.007 0.0209
Onchocerca volvulus 0.005 0.0602 0.179
Plasmodium falciparum LCCL domain-containing protein 0.002 0.016 0.1929
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0024 0.0024
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0025 0.0301
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0323 0.0323
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0052 0.0635 0.7659
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0024 0.0024
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0054 0.0655 0.1425
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0323 0.0323
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0201 0.2789 0.2789
Schistosoma mansoni lamin 0.0027 0.0272 0.0272
Schistosoma mansoni rab6-interacting 0.002 0.016 0.016
Leishmania major heat shock protein 83-1 0.0066 0.083 1
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0013 0.007 0.0846
Brugia malayi hypothetical protein 0.002 0.016 0.0348
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0013 0.007 0.0846
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0602 0.0602
Brugia malayi hypothetical protein 0.0036 0.0404 0.0879
Loa Loa (eye worm) hypothetical protein 0.0027 0.0272 0.0591
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0088 0.0191
Schistosoma mansoni hypothetical protein 0.0049 0.0584 0.0584
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0053
Schistosoma mansoni heat shock protein 0.0027 0.0267 0.0267
Echinococcus multilocularis heat shock protein 90 0.0066 0.083 0.083
Echinococcus multilocularis heat shock protein 90 0.0052 0.0635 0.0635
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0013 0.007 0.1105
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0024 0.0053
Echinococcus granulosus heat shock protein 90 0.0066 0.083 0.083
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0117 0.1575 0.1575
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.016 0.1929
Echinococcus granulosus lamin dm0 0.0027 0.0272 0.0272
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0024 0.0053
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0013 0.007 0.1105
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0159 0.0159
Trichomonas vaginalis heat shock protein, putative 0.0052 0.0635 0.1891
Schistosoma mansoni endoplasmin 0.0066 0.083 0.083
Schistosoma mansoni loxhd1 0.002 0.016 0.016
Trypanosoma cruzi Heat shock protein 83, putative 0.0066 0.083 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0024 0.0024
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0052 0.0635 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0067 0.0067
Echinococcus granulosus heat shock protein 90 0.0052 0.0635 0.0635
Trypanosoma cruzi heat shock protein, putative 0.0027 0.0267 0.3215
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0298 0.0298
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0013 0.007 0.1105
Brugia malayi Endoplasmin precursor 0.0066 0.083 0.1806
Giardia lamblia DINP protein human, muc B family 0.002 0.0159 0.1918
Entamoeba histolytica heat shock protein 90, putative 0.0066 0.083 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0054 0.0655 0.7892
Schistosoma mansoni hypothetical protein 0.0028 0.0275 0.0275
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0655 0.1949
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0655 0.1949
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0159 0.1918
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0024 0.0053
Schistosoma mansoni heat shock protein 0.0066 0.083 0.083
Giardia lamblia Heat shock protein HSP 90-alpha 0.0066 0.083 1
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0013 0.007 0.1105
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0655 0.1949
Loa Loa (eye worm) heat shock protein 90 0.0066 0.083 0.1806
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0024 0.0024
Schistosoma mansoni polycystin 1-related 0.002 0.016 0.016
Trypanosoma brucei heat shock protein, putative 0.0066 0.083 1
Schistosoma mansoni intermediate filament proteins 0.0027 0.0272 0.0272
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0159 0.1918
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0024 0.0024
Leishmania major heat shock protein 83-1 0.0066 0.083 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0159 0.1918
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0159 0.0346
Brugia malayi Hsp90 protein 0.0027 0.0267 0.0581
Plasmodium falciparum DNA gyrase subunit B 0.0013 0.007 0.0846
Mycobacterium tuberculosis Probable two component sensor kinase 0.0013 0.007 0.1105
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0159 0.0474
Loa Loa (eye worm) hypothetical protein 0.0013 0.006 0.013
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0024 0.0053
Leishmania major hypothetical protein, conserved 0.0013 0.007 0.0846
Echinococcus granulosus lamin 0.0027 0.0272 0.0272
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0013 0.007 0.1105
Trypanosoma brucei unspecified product 0.0013 0.0071 0.0859
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0013 0.007 0.1105
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0024 0.0024
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0013 0.007 0.0846
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0323 0.0323
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0108 0.0108
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0027 0.0267 0.0267
Trypanosoma brucei DNA polymerase eta, putative 0.0045 0.0533 0.6422
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0354 0.4273
Brugia malayi ecdysteroid receptor 0.001 0.0024 0.0053
Echinococcus granulosus intermediate filament protein 0.0027 0.0272 0.0272
Trypanosoma brucei unspecified product 0.0013 0.0071 0.0859
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0108 0.1299
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0655 0.1949
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0159 0.1918
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0067 0.0067
Entamoeba histolytica hypothetical protein 0.0036 0.0404 0.4867
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0108 0.0235
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0354 0.4273
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0024 0.0024
Leishmania major DNA polymerase eta, putative 0.0045 0.0533 0.6422
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0533 0.6422
Brugia malayi hypothetical protein 0.0089 0.1169 0.2544
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0013 0.007 0.0846
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0159 0.1918
Brugia malayi intermediate filament protein 0.0027 0.0272 0.0591
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0108 0.0235
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0013 0.007 0.0153
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0323 0.0323
Loa Loa (eye worm) hypothetical protein 0.0054 0.0655 0.1425
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0013 0.007 0.0153
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.016 0.016
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0013 0.007 0.1105
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0013 0.007 0.1105
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0013 0.007 0.1105
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0013 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0089 0.1169 0.2544
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0159 0.2504
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0013 0.007 0.0209
Loa Loa (eye worm) hypothetical protein 0.005 0.0602 0.1309
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0533 0.116
Trypanosoma cruzi metacaspase, putative 0.0054 0.0655 0.7892
Trichomonas vaginalis receptor histidine kinase, putative 0.0013 0.007 0.0209
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0108 0.0108
Trichomonas vaginalis DNA topoisomerase II, putative 0.0013 0.007 0.0209
Echinococcus multilocularis caspase 2 0.0054 0.0655 0.0655
Leishmania major DNA polymerase eta, putative 0.0032 0.0338 0.4069

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 27 nM In vitro inhibitory activity against human leukocyte elastase (HLE) mediated hydrolysis of the synthetic substrate MeOSuc-Ala-Ala-Pro-Val-pNA ChEMBL. 7837244
Ki (binding) = 27 nM In vitro inhibitory activity against human leukocyte elastase (HLE) mediated hydrolysis of the synthetic substrate MeOSuc-Ala-Ala-Pro-Val-pNA ChEMBL. 7837244

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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