Detailed information for compound 307817

Basic information

Technical information
  • TDR Targets ID: 307817
  • Name: 5H-pyrido[3,2-b]indol-8-ol
  • MW: 184.194 | Formula: C11H8N2O
  • H donors: 2 H acceptors: 2 LogP: 2.05 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc2c(c1)c1ncccc1[nH]2
  • InChi: 1S/C11H8N2O/c14-7-3-4-9-8(6-7)11-10(13-9)2-1-5-12-11/h1-6,13-14H
  • InChiKey: NYZURWHDDKWNDP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0036 0.0404 0.4867
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0024 0.0053
Giardia lamblia Pms1-like protein 0.0013 0.007 0.0846
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0024 0.0024
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0053
Toxoplasma gondii Hsp90 domain-containing protein 0.0027 0.0267 0.3215
Echinococcus granulosus hypothetical protein 0.0027 0.0275 0.0275
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0024 0.0053
Trypanosoma cruzi heat shock protein 90, putative 0.0052 0.0635 0.7659
Schistosoma mansoni heat shock protein 0.0066 0.083 0.083
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0024 0.0053
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0201 0.2789 0.2789
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.0439 0.529
Loa Loa (eye worm) TOPoisomerase family member 0.0013 0.007 0.0153
Trichomonas vaginalis rotamase, putative 0.0034 0.0366 0.1089
Mycobacterium tuberculosis Conserved protein 0.0013 0.007 0.1105
Brugia malayi isocitrate dehydrogenase 0.0016 0.0108 0.0235
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0027 0.0267 0.0267
Toxoplasma gondii heat shock protein 75, putative 0.0027 0.0267 0.3215
Loa Loa (eye worm) hypothetical protein 0.0031 0.0323 0.0703
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0655 0.1949
Entamoeba histolytica hypothetical protein 0.0036 0.0404 0.4867
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0054 0.0655 0.7892
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0024 0.0053
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0323 0.0323
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0013 0.007 0.0209
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0013 0.007 0.0846
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0013 0.007 0.1105
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0108 0.1299
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0366 0.0797
Echinococcus granulosus expressed protein 0.0034 0.0366 0.0366
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0013 0.007 0.007
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0024 0.0053
Schistosoma mansoni thyroid hormone receptor 0.001 0.0024 0.0024
Echinococcus multilocularis caspase 0.0201 0.2789 0.2789
Brugia malayi kinase, mitochondrial precursor 0.0013 0.007 0.0153
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0013 0.007 0.1105
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0655 0.1949
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0354 0.4273
Trichomonas vaginalis receptor histidine kinase, putative 0.0013 0.007 0.0209
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0655 0.1949
Leishmania major heat shock protein 83-1 0.0066 0.083 1
Schistosoma mansoni survival motor neuron protein 0.0049 0.0584 0.0584
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0298 0.0298
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0323 0.0323
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0013 0.007 0.007
Plasmodium vivax hypothetical protein, conserved 0.0054 0.0655 0.7892
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0655 0.1949
Echinococcus multilocularis musashi 0.0027 0.0272 0.0272
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0024 0.0024
Schistosoma mansoni cpg binding protein 0.0031 0.0321 0.0321
Onchocerca volvulus 0.0027 0.0272 0.0808
Schistosoma mansoni intermediate filament proteins 0.0027 0.0272 0.0272
Trichomonas vaginalis heat shock protein, putative 0.0052 0.0635 0.1891
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0024 0.0053
Mycobacterium leprae Probable two-component sensor kinase 0.0013 0.007 0.1105
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0024 0.0024
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0024 0.0024
Schistosoma mansoni caspase-7 (C14 family) 0.0054 0.0655 0.0655
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0167 0.0167
Echinococcus granulosus dna polymerase kappa 0.0019 0.0159 0.0159
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0354 0.4273
Trichomonas vaginalis DNA topoisomerase II, putative 0.0013 0.007 0.0209
Onchocerca volvulus 0.002 0.0167 0.0496
Leishmania major heat shock protein 83-1 0.0066 0.083 1
Leishmania major heat shock protein 83-1 0.0066 0.083 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0108 0.0108
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0024 0.0053
Echinococcus multilocularis endoplasmin 0.0052 0.0635 0.0635
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0159 0.1918
Trypanosoma brucei unspecified product 0.0013 0.0071 0.0859
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0655 0.1949
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0024 0.0053
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0053
Echinococcus granulosus protein quaking 0.0027 0.0275 0.0275
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0067 0.0067
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0159 0.0159
Leishmania major developmentally regulated phosphoprotein-like protein 0.0013 0.007 0.0846
Echinococcus granulosus caspase 8 0.0054 0.0655 0.0655
Brugia malayi hypothetical protein 0.002 0.0167 0.0363
Trypanosoma cruzi heat shock protein 85, putative 0.0066 0.083 1
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0167 0.2008
Leishmania major heat shock protein 83-1 0.0066 0.083 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0264 0.0576
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0159 0.1918
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0167 0.0167
Plasmodium vivax SET domain protein, putative 0.0031 0.0323 0.3895
Schistosoma mansoni hypothetical protein 0.0413 0.5877 0.5877
Schistosoma mansoni lipoxygenase 0.0084 0.1091 0.1091
Trypanosoma brucei heat shock protein, putative 0.0066 0.083 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0052 0.0635 0.7659
Echinococcus granulosus FTZ F1 alpha 0.001 0.0024 0.0024
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0024 0.0053
Brugia malayi heat shock protein 90 0.0066 0.083 0.1806
Trichomonas vaginalis set domain proteins, putative 0.024 0.336 1
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0108 0.1299
Plasmodium vivax DNA gyrase subunit B, putative 0.0013 0.007 0.0846
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0013 0.006 0.013
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0655 0.1949
Schistosoma mansoni cpg binding protein 0.0031 0.0321 0.0321
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0024 0.0024
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0013 0.007 0.0846
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0024 0.0072
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0024 0.0024
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0108 0.0235
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0159 0.0346
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0053
Leishmania major heat shock protein 83-1 0.0066 0.083 1
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0354 0.4273
Brugia malayi Pre-SET motif family protein 0.0031 0.0323 0.0703
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0013 0.007 0.0153
Echinococcus multilocularis tumor protein p63 0.0341 0.4833 0.4833
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0108 0.1299
Trypanosoma brucei metacaspase MCA3 0.0054 0.0655 0.7892
Loa Loa (eye worm) hypothetical protein 0.0027 0.0275 0.0599
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0067 0.0067
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0159 0.1918
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0404 0.0404
Leishmania major metacaspase, putative 0.0054 0.0655 0.7892
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0013 0.007 0.0846
Schistosoma mansoni endoplasmin 0.0066 0.083 0.083
Trypanosoma brucei heat shock protein, putative 0.0066 0.083 1
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0354 0.4273
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0159 0.1918
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0024 0.0024
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0052 0.0635 1
Plasmodium falciparum metacaspase 1 0.0054 0.0655 0.7892
Echinococcus granulosus caspase 2 0.0054 0.0655 0.0655
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0013 0.007 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0053
Schistosoma mansoni DNA polymerase eta 0.0045 0.0533 0.0533
Trypanosoma brucei heat shock protein, putative 0.0066 0.083 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0024 0.0053
Echinococcus multilocularis heat shock protein 90 0.0066 0.083 0.083
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0049 0.0584 0.0584
Loa Loa (eye worm) hypothetical protein 0.0027 0.0272 0.0591
Echinococcus granulosus arachidonate 5 lipoxygenase 0.012 0.1614 0.1614
Loa Loa (eye worm) hypothetical protein 0.002 0.0167 0.0363
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0272 0.0591
Echinococcus multilocularis heat shock protein 90 0.0052 0.0635 0.0635
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0013 0.007 0.0209
Echinococcus granulosus heat shock protein 90 0.0066 0.083 0.083
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0022 0.0022
Brugia malayi Doublecortin family protein 0.002 0.0167 0.0363
Trichomonas vaginalis heat shock protein, putative 0.0052 0.0635 0.1891
Schistosoma mansoni endoplasmin 0.0066 0.083 0.083
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0159 0.1918
Onchocerca volvulus 0.001 0.0024 0.0072
Trypanosoma cruzi Heat shock protein 83, putative 0.0066 0.083 1
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0052 0.0635 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0025 0.0301
Trypanosoma cruzi DNA topoisomerase II, putative 0.0013 0.007 0.0846
Schistosoma mansoni lamin 0.0027 0.0272 0.0272
Brugia malayi Endoplasmin precursor 0.0066 0.083 0.1806
Plasmodium falciparum DNA gyrase subunit B 0.0013 0.007 0.0846
Brugia malayi CXXC zinc finger family protein 0.0029 0.0297 0.0647
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0167 0.0167
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0013 0.007 0.0209
Echinococcus granulosus heat shock protein 90 0.0052 0.0635 0.0635
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0013 0.007 0.0846
Trypanosoma brucei metacaspase MCA2 0.0054 0.0655 0.7892
Plasmodium vivax hypothetical protein, conserved 0.0013 0.007 0.0846
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0108 0.1299
Onchocerca volvulus 0.024 0.336 1
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0013 0.007 0.0209
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0013 0.007 0.0153
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0024 0.0053
Loa Loa (eye worm) hypothetical protein 0.0013 0.0067 0.0146
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0013 0.007 0.1105
Echinococcus multilocularis protein quaking 0.0027 0.0275 0.0275
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0159 0.2504
Onchocerca volvulus 0.005 0.0602 0.179
Schistosoma mansoni hypothetical protein 0.002 0.0167 0.0167
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0024 0.0072
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0201 0.2789 0.2789
Brugia malayi hypothetical protein 0.0027 0.0275 0.0599
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0323 0.0323
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.001 0.0025 0.0301
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0052 0.0635 0.7659
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0024 0.0024
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0323 0.3895
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0054 0.0655 0.1425
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0159 0.0474
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0013 0.007 0.1105
Brugia malayi hypothetical protein 0.0036 0.0404 0.0879
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0602 0.0602
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0088 0.0191
Schistosoma mansoni heat shock protein 0.0027 0.0267 0.0267
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0159 0.1918
Leishmania major heat shock protein 83-1 0.0066 0.083 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.007 0.0153
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0024 0.0053
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0533 0.6422
Leishmania major DNA polymerase eta, putative 0.0045 0.0533 0.6422
Trypanosoma cruzi DNA topoisomerase II, putative 0.0013 0.007 0.0846
Brugia malayi hypothetical protein 0.0089 0.1169 0.2544
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0108 0.0108
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0108 0.0108
Entamoeba histolytica hypothetical protein 0.0036 0.0404 0.4867
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0013 0.007 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0655 0.1949
Echinococcus granulosus RUN 0.002 0.0167 0.0167
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0354 0.4273
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0027 0.0267 0.0267
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0108 0.1299
Echinococcus granulosus cpg binding protein 0.0031 0.0321 0.0321
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0013 0.007 0.0846
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0159 0.1918
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0013 0.007 0.007
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0159 0.2504
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0013 0.007 0.1105
Trypanosoma brucei developmentally regulated phosphoprotein 0.0013 0.007 0.0846
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0013 0.007 0.0209
Loa Loa (eye worm) hypothetical protein 0.0054 0.0655 0.1425
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0013 0.007 0.1105
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0013 0.007 0.1105
Trypanosoma cruzi metacaspase, putative 0.0054 0.0655 0.7892
Trypanosoma brucei unspecified product 0.0013 0.0071 0.0859
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0108 0.1299
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0338 0.4069
Echinococcus multilocularis caspase 2 0.0054 0.0655 0.0655
Loa Loa (eye worm) hypothetical protein 0.0089 0.1169 0.2544
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0533 0.116
Plasmodium vivax DNA topoisomerase II, putative 0.0013 0.007 0.0846
Loa Loa (eye worm) hypothetical protein 0.005 0.0602 0.1309
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0159 0.1918
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0053
Schistosoma mansoni loxhd1 0.002 0.0167 0.0167
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0013 0.007 0.0209
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0655 0.1949
Giardia lamblia Heat shock protein HSP 90-alpha 0.0066 0.083 1
Schistosoma mansoni heat shock protein 0.0066 0.083 0.083
Loa Loa (eye worm) heat shock protein 90 0.0066 0.083 0.1806
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0054 0.0655 0.7892
Entamoeba histolytica heat shock protein 90, putative 0.0066 0.083 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0655 0.1949
Loa Loa (eye worm) heat shock protein 75 0.0027 0.0267 0.0581
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0655 0.1949
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0053
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0159 0.0159
Leishmania major heat shock protein 83-1 0.0066 0.083 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0159 0.0474
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0159 0.1918
Onchocerca volvulus 0.0027 0.0272 0.0808
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0013 0.007 0.1105
Trichomonas vaginalis sensor histidine kinase, putative 0.0013 0.007 0.0209
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0159 0.0159
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0024 0.0072
Trypanosoma brucei heat shock protein, putative 0.0066 0.083 1
Echinococcus granulosus intermediate filament protein 0.0027 0.0272 0.0272
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0024 0.0024
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0159 0.1918
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0013 0.007 0.1105
Plasmodium falciparum heat shock protein 90, putative 0.0027 0.0267 0.3215
Entamoeba histolytica DNA topoisomerase II, putative 0.0013 0.007 0.0846
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0013 0.007 0.1105
Leishmania major mitochondrial DNA topoisomerase II 0.0013 0.007 0.0846
Loa Loa (eye worm) hypothetical protein 0.0013 0.007 0.0153
Echinococcus multilocularis lamin 0.0027 0.0272 0.0272
Leishmania major hypothetical protein, conserved 0.0013 0.007 0.0846
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0024 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0071 0.0859
Trypanosoma brucei DNA polymerase eta, putative 0.0045 0.0533 0.6422
Trypanosoma cruzi heat shock protein, putative 0.0027 0.0267 0.3215
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0108 0.1299
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0323 0.0323
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0024 0.0053
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0354 0.4273
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0013 0.007 0.1105
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0024 0.0024
Echinococcus multilocularis dna polymerase eta 0.0045 0.0533 0.0533
Brugia malayi Temporarily assigned gene name protein 44 0.0027 0.0275 0.0599
Trypanosoma brucei Metacaspase-4 0.0054 0.0655 0.7892
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0404 0.0404
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0025 0.0301
Echinococcus multilocularis heat shock protein 0.0066 0.083 0.083
Trypanosoma cruzi heat shock protein 85, putative 0.0066 0.083 1
Trypanosoma brucei heat shock protein, putative 0.0066 0.083 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0323 0.0323
Trypanosoma brucei heat shock protein 84, putative 0.0027 0.0267 0.3215
Giardia lamblia Grp94/Hsp90 0.0052 0.0635 0.7659
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0159 0.1918
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0655 0.1949
Plasmodium falciparum heat shock protein 90 0.0066 0.083 1
Brugia malayi Pre-SET motif family protein 0.0211 0.2939 0.6396
Loa Loa (eye worm) tumor suppressor 0.0325 0.4594 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0024 0.0024
Plasmodium falciparum endoplasmin, putative 0.004 0.0461 0.5556
Trypanosoma brucei heat shock protein 90, putative 0.0066 0.083 1
Echinococcus granulosus heat shock protein 0.0066 0.083 0.083
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0159 0.1918
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0027 0.0267 0.0794
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0323 0.0323
Schistosoma mansoni rotamase 0.0034 0.0366 0.0366
Leishmania major DNA polymerase kappa, putative 0.0019 0.0159 0.1918
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0024 0.0024
Trypanosoma cruzi metacaspase, putative 0.0054 0.0655 0.7892
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0108 0.1299
Entamoeba histolytica heat shock protein 90, putative 0.0066 0.083 1
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0054 0.0655 0.0655
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0013 0.007 0.0846
Trypanosoma cruzi heat shock protein 85, putative 0.0052 0.0635 0.7659
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0053
Leishmania major heat shock protein 83-1 0.0066 0.083 1
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0013 0.007 0.1105
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0366 0.0797
Toxoplasma gondii DNA topoisomerase 2, putative 0.0013 0.007 0.0846
Echinococcus multilocularis microtubule associated protein 2 0.0697 1 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.007 0.0153
Leishmania major heat shock protein 83-1 0.0066 0.083 1
Echinococcus multilocularis caspase 3 0.0147 0.201 0.201
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0022 0.0022
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0272 0.0591
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0167 0.2008
Trypanosoma brucei metacaspase 5, putative 0.0054 0.0655 0.7892
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0159 0.1918
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0052 0.0635 0.0635
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0013 0.007 0.1105
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0272 0.0591
Mycobacterium ulcerans two component sensor kinase MprB 0.0013 0.007 0.1105
Schistosoma mansoni cpg binding protein 0.0029 0.0297 0.0297
Schistosoma mansoni nuclear hormone receptor 0.001 0.0024 0.0024
Trypanosoma cruzi metacaspase, putative 0.0054 0.0655 0.7892
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0024 0.0024
Trichomonas vaginalis rotamase, putative 0.0033 0.0354 0.1055
Schistosoma mansoni rab6-interacting 0.002 0.0167 0.0167
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0267 0.0794
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0167 0.0167
Brugia malayi tumor suppressor. 0.0325 0.4594 1
Onchocerca volvulus 0.0029 0.0297 0.0885
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0024 0.0024
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.012 0.1614 0.1614
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0159 0.1918
Schistosoma mansoni thyroid hormone receptor 0.001 0.0024 0.0024
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0323 0.0323
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0053
Echinococcus granulosus lamin 0.0027 0.0272 0.0272
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0159 0.1918
Mycobacterium ulcerans DNA gyrase subunit B 0.0013 0.007 0.1105
Mycobacterium ulcerans putative regultory protein 0.0013 0.007 0.1105
Plasmodium falciparum DNA topoisomerase 2 0.0013 0.007 0.0846
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0108 0.0108
Brugia malayi hypothetical protein 0.002 0.0167 0.0363
Loa Loa (eye worm) doublecortin family protein 0.002 0.0167 0.0363
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0013 0.007 0.1105
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.069 0.8321
Loa Loa (eye worm) hypothetical protein 0.0054 0.0655 0.1425
Brugia malayi Cell death protein 3 precursor 0.0054 0.0655 0.1425
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0655 0.1949
Brugia malayi ecdysteroid receptor 0.001 0.0024 0.0053
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0297 0.0647
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0024 0.0024
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0013 0.007 0.0741
Schistosoma mansoni eyes absent homolog 0.0089 0.1169 0.1169
Leishmania major heat shock protein 83-1 0.0066 0.083 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0108 0.1696
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0013 0.007 0.1105
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0013 0.007 0.1105
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0024 0.0053
Trypanosoma brucei heat shock protein 90, putative 0.0066 0.083 1
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0013 0.007 0.0741
Echinococcus granulosus lamin dm0 0.0027 0.0272 0.0272
Loa Loa (eye worm) hypothetical protein 0.002 0.0167 0.0363
Trichomonas vaginalis heat shock protein, putative 0.0066 0.083 0.2469
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0024 0.0053
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0013 0.007 0.0741
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0013 0.007 0.1105
Toxoplasma gondii heat shock protein 90, putative 0.0066 0.083 1
Schistosoma mansoni microtubule-associated protein tau 0.0697 1 1
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0013 0.007 0.0846
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0013 0.007 0.0846
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0024 0.0053
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0159 0.1918
Brugia malayi Hsp90 protein 0.0027 0.0267 0.0581
Entamoeba histolytica hypothetical protein 0.0036 0.0404 0.4867
Trypanosoma brucei DNA topoisomerase ii 0.0013 0.007 0.0846
Plasmodium vivax heat shock protein 90, putative 0.0027 0.0267 0.3215
Brugia malayi hypothetical protein 0.0239 0.3345 0.7282
Echinococcus granulosus caspase 0.0201 0.2789 0.2789
Echinococcus multilocularis caspase 8 0.0054 0.0655 0.0655
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0167 0.0167
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0024 0.0053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0024 0.0053
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0024 0.0024
Echinococcus multilocularis survival motor neuron protein 1 0.0239 0.3345 0.3345
Trypanosoma cruzi heat shock protein 90, putative 0.0066 0.083 1
Schistosoma mansoni lamin 0.0027 0.0272 0.0272
Trypanosoma cruzi metacaspase, putative 0.0054 0.0655 0.7892
Plasmodium vivax metacaspase 1, putative 0.0054 0.0655 0.7892
Giardia lamblia DINP protein human, muc B family 0.0019 0.0159 0.1918
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0108 0.0108
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0108 0.0235
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0013 0.007 0.1105
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.2939 0.6396
Onchocerca volvulus 0.0031 0.0323 0.0962
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0025 0.0301
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0024 0.0024
Schistosoma mansoni rab6-interacting 0.002 0.0167 0.0167
Schistosoma mansoni polycystin 1-related 0.002 0.0167 0.0167
Leishmania major heat shock protein 83-1 0.0066 0.083 1
Schistosoma mansoni lipoxygenase 0.012 0.1614 0.1614
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0024 0.0053
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0052 0.0635 1
Brugia malayi steroid hormone receptor 0.001 0.0024 0.0053
Trichomonas vaginalis receptor histidine kinase, putative 0.0013 0.007 0.0209
Trypanosoma cruzi heat shock protein 85, putative 0.0066 0.083 1
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0013 0.007 0.007
Brugia malayi intermediate filament protein 0.0027 0.0272 0.0591
Loa Loa (eye worm) hypothetical protein 0.0089 0.1169 0.2544
Brugia malayi nuclear receptor NHR-88 0.001 0.0024 0.0053
Chlamydia trachomatis DNA gyrase subunit B 0.0013 0.007 1
Schistosoma mansoni hypothetical protein 0.0027 0.0275 0.0275
Trichomonas vaginalis heat shock protein, putative 0.0052 0.0635 0.1891
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0108 0.1299
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.001 0.0025 0.0301
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0338 0.4069
Mycobacterium tuberculosis Probable two component sensor kinase 0.0013 0.007 0.1105
Loa Loa (eye worm) hypothetical protein 0.0045 0.0533 0.116
Echinococcus multilocularis cpg binding protein 0.0031 0.0321 0.0321
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0024 0.0024
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0013 0.007 0.0209
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0786 0.0786
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0655 0.1949
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0013 0.007 0.0209
Echinococcus multilocularis dnaJ subfamily B 0.0413 0.5877 0.5877
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0027 0.0267 0.3215
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0024 0.0053
Echinococcus granulosus tumor protein p63 0.0341 0.4833 0.4833
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0013 0.007 0.0846
Toxoplasma gondii heat shock protein HSP90 0.0066 0.083 1
Chlamydia trachomatis DNA gyrase subunit B 0.0013 0.007 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0024 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0071 0.0859
Plasmodium vivax heat shock protein 86, putative 0.0066 0.083 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.006 0.013
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0655 0.1949
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0108 0.0108
Trypanosoma brucei metacaspase 0.0054 0.0655 0.7892
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0159 0.1918
Brugia malayi Probable DNA topoisomerase II 0.0013 0.007 0.0153
Schistosoma mansoni DNA topoisomerase II 0.0013 0.007 0.007
Trypanosoma brucei heat shock protein, putative 0.0066 0.083 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0024 0.0053
Echinococcus granulosus caspase 3 0.0147 0.201 0.201
Schistosoma mansoni hypothetical protein 0.0036 0.0404 0.0404
Plasmodium vivax endoplasmin, putative 0.0066 0.083 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0024 0.0024
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0054 0.0655 0.7892
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0167 0.0167
Schistosoma mansoni caspase-7 (C14 family) 0.0201 0.2789 0.2789
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0088 0.0191
Mycobacterium leprae Probable two component sensor kinase MprB 0.0013 0.007 0.1105
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0013 0.007 0.1105
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0024 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0159 0.1918
Plasmodium vivax heat shock protein, putative 0.0027 0.0267 0.3215
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0013 0.007 0.0846
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0013 0.007 0.1105
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0071 0.0859
Echinococcus granulosus dnaJ subfamily B 0.0413 0.5877 0.5877
Loa Loa (eye worm) endoplasmin 0.0066 0.083 0.1806
Mycobacterium tuberculosis Possible two component sensor kinase 0.0013 0.007 0.1105
Echinococcus multilocularis lamin dm0 0.0027 0.0272 0.0272
Loa Loa (eye worm) histone methyltransferase 0.001 0.0022 0.0049
Brugia malayi nuclear hormone receptor 0.001 0.0024 0.0053
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0024 0.0024
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0024 0.0024
Echinococcus granulosus endoplasmin 0.0052 0.0635 0.0635
Loa Loa (eye worm) hypothetical protein 0.0239 0.3345 0.7282
Echinococcus granulosus dna polymerase eta 0.0045 0.0533 0.0533
Leishmania major DNA topoisomerase ii 0.0013 0.007 0.0846
Trypanosoma brucei heat shock protein, putative 0.0066 0.083 1
Trypanosoma brucei heat shock protein, putative 0.0066 0.083 1
Mycobacterium ulcerans heat shock protein 90 0.0052 0.0635 1
Onchocerca volvulus 0.0049 0.0584 0.1737
Trypanosoma brucei unspecified product 0.0019 0.0159 0.1918
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0021 0.0045
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0013 0.007 0.1105
Mycobacterium ulcerans two component regulator - sensor kinase 0.0013 0.007 0.1105
Schistosoma mansoni coup transcription factor 0.001 0.0024 0.0024
Trichomonas vaginalis endoplasmin, putative 0.004 0.0461 0.1372
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0024 0.0053
Schistosoma mansoni pyruvate dehydrogenase 0.0013 0.007 0.007
Echinococcus multilocularis RUN 0.002 0.0167 0.0167
Echinococcus granulosus survival motor neuron protein 1 0.0239 0.3345 0.3345
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0108 0.0108
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0013 0.007 0.1105
Trypanosoma brucei Heat shock protein 83, putative 0.0066 0.083 1
Leishmania major heat shock protein 83-1 0.0066 0.083 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0159 0.2504
Schistosoma mansoni caspase-3 (C14 family) 0.0201 0.2789 0.2789
Leishmania major heat shock protein 83-1 0.0066 0.083 1
Leishmania major heat shock protein 83-1 0.0066 0.083 1
Leishmania major heat shock protein 83-1 0.0066 0.083 1
Trypanosoma cruzi metacaspase 5, putative 0.0054 0.0655 0.7892
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0159 0.0159
Leishmania major DNA polymerase eta, putative 0.0032 0.0338 0.4069
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0013 0.007 0.0846
Schistosoma mansoni hypothetical protein 0.0027 0.0275 0.0275
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0655 0.1949
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0159 0.0159
Treponema pallidum heat shock protein 90 0.0052 0.0635 1
Leishmania major heat shock protein 83-1 0.0066 0.083 1
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0013 0.007 0.1105
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0404 0.0404
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0584 0.127
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0366 0.1089
Echinococcus multilocularis expressed protein 0.0034 0.0366 0.0366
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0159 0.2504
Plasmodium falciparum heat shock protein 90, putative 0.0027 0.0267 0.3215
Leishmania major heat shock protein, putative 0.0027 0.0267 0.3215
Onchocerca volvulus Cell death protein 3 homolog 0.0054 0.0655 0.1949
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0159 0.0346
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0159 0.1918
Trypanosoma cruzi metacaspase 5, putative 0.0054 0.0655 0.7892
Trichomonas vaginalis heat shock protein, putative 0.004 0.0461 0.1372
Leishmania major heat shock protein 83-1 0.0066 0.083 1
Onchocerca volvulus 0.002 0.0167 0.0496
Plasmodium falciparum metacaspase-like protein 0.0054 0.0655 0.7892

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 56.5 uM Antiplasmodial activity against chloroquine-resistant K1 strain of Plasmodium falciparum ChEMBL. 11300877
IC50 (functional) = 56.5 uM Antiplasmodial activity against chloroquine-resistant K1 strain of Plasmodium falciparum ChEMBL. 11300877
IC50 (functional) = 122 uM Antitrypanosomial activity against Trypanosoma cruzi amastigotes ChEMBL. 11300877
IC50 (functional) = 122 uM Antitrypanosomial activity against Trypanosoma cruzi amastigotes ChEMBL. 11300877
IC50 (functional) = 129 uM Antitrypanosomial activity against Trypanosoma cruzi epimastigotes ChEMBL. 11300877
IC50 (functional) = 129 uM Antitrypanosomial activity against Trypanosoma cruzi epimastigotes ChEMBL. 11300877
IC50 (functional) = 200 uM Antitrypanosomial activity against (T. cruzi) trypomastigotes (concentration of compound tested on trypomastigote motility) ChEMBL. 11300877
IC50 (functional) = 200 uM Antitrypanosomial activity against (T. cruzi) trypomastigotes (concentration of compound tested on trypomastigote motility) ChEMBL. 11300877
IC50 (functional) = 235 uM In vitro cytotoxicity against L6 cells ChEMBL. 11300877
IS (functional) = 1.9 Index of selectivity was determined in T. cruzi ChEMBL. 11300877
IS (functional) = 4.2 Index of selectivity was determined in P. falciparum ChEMBL. 11300877

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.