Detailed information for compound 311909

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 851.003 | Formula: C42H62N10O9
  • H donors: 10 H acceptors: 9 LogP: 2.44 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 3
  • SMILES: CC[C@@H]([C@@H]1NC(=O)[C@@H](CCCCNC(=O)[C@@H](NC(=O)[C@@H](N(C(=O)[C@@H](NC1=O)CCc1ccc(cc1)O)C)C)Cc1ccccc1)NC(=O)N[C@H](C(=O)O)CCCNC(=N)N)C
  • InChi: 1S/C42H62N10O9/c1-5-25(2)34-38(57)47-31(21-18-27-16-19-29(53)20-17-27)39(58)52(4)26(3)35(54)48-33(24-28-12-7-6-8-13-28)36(55)45-22-10-9-14-30(37(56)51-34)49-42(61)50-32(40(59)60)15-11-23-46-41(43)44/h6-8,12-13,16-17,19-20,25-26,30-34,53H,5,9-11,14-15,18,21-24H2,1-4H3,(H,45,55)(H,47,57)(H,48,54)(H,51,56)(H,59,60)(H4,43,44,46)(H2,49,50,61)/t25-,26-,30+,31-,32-,33-,34-/m0/s1
  • InChiKey: RAUPUVQHUFXDQT-IYLLGVDMSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens carboxypeptidase A1 (pancreatic) Starlite/ChEMBL References
Homo sapiens carboxypeptidase B2 (plasma) Starlite/ChEMBL References
Homo sapiens coagulation factor XI Starlite/ChEMBL References
Homo sapiens carboxypeptidase N, polypeptide 1 Starlite/ChEMBL References
Homo sapiens coagulation factor II (thrombin) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii PAN domain-containing protein Get druggable targets OG5_134971 All targets in OG5_134971
Toxoplasma gondii PAN domain-containing protein Get druggable targets OG5_134971 All targets in OG5_134971
Neospora caninum hypothetical protein Get druggable targets OG5_134971 All targets in OG5_134971
Neospora caninum hypothetical protein Get druggable targets OG5_134971 All targets in OG5_134971
Neospora caninum hypothetical protein Get druggable targets OG5_134971 All targets in OG5_134971
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) hypothetical protein carboxypeptidase B2 (plasma) 386 aa 324 aa 34.9 %
Echinococcus multilocularis subfamily M14A unassigned peptidase carboxypeptidase A1 (pancreatic) 419 aa 402 aa 33.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) TAR-binding protein 0.0211 0.2473 0.4819
Leishmania major hypothetical protein, conserved 0.0023 0.0021 0.0301
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0025 0.0054 0.0202
Onchocerca volvulus Cytosolic carboxypeptidase 1 homolog 0.0035 0.018 0.1092
Brugia malayi ImpB/MucB/SamB family protein 0.0061 0.0513 0.1
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0023 0.0021 0.0301
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0023 0.0021 0.0042
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.0513 0.7189
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0061 0.0513 0.3138
Leishmania major heat shock protein 83-1 0.0032 0.0138 0.1936
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0513 0.7102
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0021 0.0301
Loa Loa (eye worm) hypothetical protein 0.0066 0.0584 0.1139
Onchocerca volvulus 0.0023 0.0022 0.013
Trypanosoma brucei heat shock protein, putative 0.0032 0.0138 0.1686
Loa Loa (eye worm) hypothetical protein 0.0113 0.1193 0.2326
Brugia malayi Sodium:solute symporter family protein 0.0046 0.032 0.0623
Brugia malayi hypothetical protein 0.0113 0.1195 0.233
Onchocerca volvulus Subfamily M14A unassigned peptidase homolog 0.0148 0.165 1
Onchocerca volvulus 0.0148 0.165 1
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0023 0.0021 0.0021
Mycobacterium ulcerans DNA polymerase IV 0.0061 0.0513 0.3138
Echinococcus granulosus heat shock protein 90 0.0025 0.0054 0.0054
Toxoplasma gondii heat shock protein HSP90 0.0032 0.0138 0.0317
Brugia malayi PAN domain containing protein 0.0023 0.0022 0.0042
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0023 0.0021 0.0021
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0023 0.0021 0.0301
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0022 0.0043
Leishmania major DNA polymerase kappa, putative 0.0061 0.0513 0.7189
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0043
Trypanosoma brucei heat shock protein, putative 0.0032 0.0138 0.1686
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.3538 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0061 0.0513 0.1
Echinococcus granulosus Zinc carboxypeptidase family protein 0.0035 0.018 0.018
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0023 0.0021 0.0301
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0253 0.0494
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0138 0.1936
Echinococcus multilocularis cytosolic carboxypeptidase protein 5 0.0035 0.018 0.018
Loa Loa (eye worm) zinc carboxypeptidase 0.0035 0.018 0.0351
Plasmodium vivax basic transcription factor 3b, putative 0.0076 0.0713 1
Leishmania major cAMP-specific phosphodiesterase, putative 0.0023 0.0021 0.0301
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0056 0.0452 0.0452
Schistosoma mansoni endoplasmin 0.0032 0.0138 0.0269
Echinococcus multilocularis musashi 0.0116 0.1233 0.1233
Loa Loa (eye worm) endoplasmin 0.0032 0.0138 0.0269
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0021 0.0301
Schistosoma mansoni high-affinity choline transporter 0.0416 0.5131 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0023 0.0021 0.0042
Echinococcus granulosus sodium:myo inositol cotransporter 0.0046 0.032 0.032
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0513 0.7102
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0061 0.0513 0.7189
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0023 0.0021 0.0042
Brugia malayi PAN domain containing protein 0.0023 0.0022 0.0042
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0035 0.018 0.0451
Echinococcus multilocularis tar DNA binding protein 0.0211 0.2473 0.2473
Toxoplasma gondii hypothetical protein 0.0023 0.0022 0.0049
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0021 0.0301
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0023 0.0021 0.0042
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0022 0.0043
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0023 0.0021 0.0042
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0138 0.033
Loa Loa (eye worm) hypothetical protein 0.0023 0.0021 0.0042
Giardia lamblia Nuclear ATP/GTP-binding protein 0.0035 0.018 0.0451
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0021 0.0301
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.0513 0.7189
Echinococcus granulosus intermediate filament protein 0.0116 0.1233 0.1233
Schistosoma mansoni inositol transporter 0.0046 0.032 0.0623
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0021 0.0301
Entamoeba histolytica transcription factor BTF3, putative 0.0076 0.0713 0.1967
Echinococcus multilocularis solute carrier family 5 0.0046 0.032 0.032
Trypanosoma brucei Carboxypeptidase-like protein 0.0035 0.018 0.2294
Leishmania major heat shock protein 83-1 0.0032 0.0138 0.1936
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0021 0.0301
Schistosoma mansoni carboxypeptidase N (M14 family) 0.0035 0.018 0.0351
Mycobacterium tuberculosis Conserved hypothetical protein 0.0061 0.0513 0.3138
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0062 0.0532 0.1037
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0138 0.1686
Onchocerca volvulus 0.0023 0.0022 0.013
Trypanosoma brucei transcription factor BTF3, putative 0.0076 0.0713 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.018 0.0351
Trypanosoma brucei heat shock protein, putative 0.0032 0.0138 0.1686
Loa Loa (eye worm) heat shock protein 90 0.0032 0.0138 0.0269
Onchocerca volvulus 0.0035 0.018 0.1092
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0054 0.0091
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0035 0.018 0.0451
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0138 0.1936
Onchocerca volvulus 0.0047 0.0339 0.2054
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0021 0.0049
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0046 0.032 0.032
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0513 0.7102
Trypanosoma cruzi Heat shock protein 83, putative 0.0032 0.0138 0.1936
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0153 0.1709 0.333
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0023 0.0021 0.0021
Leishmania major basic transcription factor 3a, putative 0.0076 0.0713 1
Trypanosoma brucei heat shock protein, putative 0.0032 0.0138 0.1686
Schistosoma mansoni protease m14 carboxypeptidase 0.0035 0.018 0.0351
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0023 0.0021 0.0301
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0499 0.0972
Onchocerca volvulus 0.0035 0.018 0.1092
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.0513 0.7102
Echinococcus multilocularis lamin dm0 0.0116 0.1233 0.1233
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0035 0.018 0.0451
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0155 0.0849
Loa Loa (eye worm) hypothetical protein 0.0035 0.018 0.0351
Brugia malayi heat shock protein 90 0.0032 0.0138 0.0269
Echinococcus granulosus lamin 0.0116 0.1233 0.1233
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0021 0.0049
Schistosoma mansoni hypothetical protein 0.0203 0.2359 0.4598
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0116 0.1233 0.2404
Trypanosoma cruzi heat shock protein 90, putative 0.0025 0.0054 0.0751
Schistosoma mansoni sodium/solute symporter 0.0046 0.032 0.0623
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0022 0.0043
Giardia lamblia Heat shock protein HSP 90-alpha 0.0032 0.0138 0.0332
Brugia malayi Cytochrome P450 family protein 0.0023 0.002 0.0039
Trypanosoma cruzi transcription factor btf3, putative 0.0076 0.0713 1
Schistosoma mansoni endoplasmin 0.0032 0.0138 0.0269
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0713 0.1968
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0035 0.018 0.0451
Loa Loa (eye worm) RNA binding protein 0.0211 0.2473 0.4819
Entamoeba histolytica hypothetical protein 0.0113 0.1195 0.3338
Echinococcus granulosus muscleblind protein 0.0145 0.1605 0.1605
Schistosoma mansoni intermediate filament proteins 0.0116 0.1233 0.2404
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0243 0.2884 0.5622
Brugia malayi cytoplasmic intermediate filament protein 0.0062 0.0532 0.1037
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0211 0.2473 0.4819
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.3538 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0153 0.1709 0.1709
Trypanosoma brucei Heat shock protein 83, putative 0.0032 0.0138 0.1686
Brugia malayi Zinc carboxypeptidase family protein 0.0066 0.0584 0.1139
Toxoplasma gondii flagellar/basal body protein 0.0035 0.018 0.0413
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0023 0.0021 0.0042
Toxoplasma gondii zinc carboxypeptidase superfamily protein 0.0035 0.018 0.0413
Loa Loa (eye worm) hypothetical protein 0.0023 0.0021 0.0042
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0143 0.1587 1
Trichomonas vaginalis carboxypeptidase regulatory region-containing protein, putative 0.0031 0.0127 0.0301
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0143 0.1587 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0023 0.0021 0.0042
Schistosoma mansoni inositol monophosphatase 0.0037 0.0205 0.04
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0023 0.0021 0.0021
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.0513 0.7189
Brugia malayi Intermediate filament tail domain containing protein 0.0116 0.1233 0.2404
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0061 0.0513 0.0513
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0021 0.0049
Onchocerca volvulus 0.0023 0.0022 0.013
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0205 0.0523
Echinococcus multilocularis dna polymerase eta 0.0061 0.0513 0.0513
Trypanosoma cruzi zinc carboxypeptidase, putative 0.0035 0.018 0.2526
Loa Loa (eye worm) hypothetical protein 0.0035 0.018 0.0351
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0205 0.2876
Schistosoma mansoni inositol transporter 0.0046 0.032 0.0623
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0021 0.0049
Brugia malayi hypothetical protein 0.0146 0.1629 0.3175
Echinococcus granulosus endoplasmin 0.0025 0.0054 0.0054
Echinococcus granulosus heat shock protein 90 0.0032 0.0138 0.0138
Onchocerca volvulus 0.0023 0.0022 0.013
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0023 0.0021 0.0042
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0021 0.0049
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.002 0.0039
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0023 0.0021 0.0042
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0153 0.1709 0.333
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0513 0.7102
Loa Loa (eye worm) hypothetical protein 0.0035 0.018 0.0351
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0153 0.1709 0.333
Schistosoma mansoni tar DNA-binding protein 0.0211 0.2473 0.4819
Mycobacterium ulcerans DNA polymerase IV 0.0061 0.0513 0.3138
Plasmodium vivax hypothetical protein, conserved 0.0035 0.018 0.2526
Echinococcus multilocularis heat shock protein 0.0032 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0042
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0202 0.2354 0.2354
Loa Loa (eye worm) PAN domain-containing protein 0.0023 0.0022 0.0042
Toxoplasma gondii PAN/Apple domain-containing protein 0.0023 0.0022 0.0049
Loa Loa (eye worm) hypothetical protein 0.0023 0.0021 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0513 0.7102
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0513 0.7102
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0021 0.0301
Loa Loa (eye worm) hypothetical protein 0.0146 0.1629 0.3175
Toxoplasma gondii zinc carboxypeptidase superfamily protein 0.0035 0.018 0.0413
Schistosoma mansoni hypothetical protein 0.0035 0.018 0.0351
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.2742 0.2742
Giardia lamblia Nuclear ATP/GTP-binding protein 0.0035 0.018 0.0451
Brugia malayi Zinc carboxypeptidase family protein 0.0035 0.018 0.0351
Loa Loa (eye worm) hypothetical protein 0.0232 0.2742 0.5344
Loa Loa (eye worm) hypothetical protein 0.0145 0.1605 0.3129
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0042
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.0513 0.7102
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.3538 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0043
Schistosoma mansoni inositol monophosphatase 0.0037 0.0205 0.04
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0035 0.018 0.0451
Toxoplasma gondii hypothetical protein 0.0023 0.0022 0.0049
Echinococcus granulosus lamin dm0 0.0116 0.1233 0.1233
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0138 0.1936
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0138 0.1686
Brugia malayi TAR-binding protein 0.0211 0.2473 0.4819
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0138 0.1936
Onchocerca volvulus 0.0023 0.0022 0.013
Leishmania major heat shock protein 83-1 0.0032 0.0138 0.1936
Brugia malayi PAN domain containing protein 0.0023 0.0022 0.0042
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0138 0.0332
Loa Loa (eye worm) hypothetical protein 0.0035 0.018 0.0351
Echinococcus multilocularis endoplasmin 0.0025 0.0054 0.0054
Plasmodium vivax heat shock protein 86, putative 0.0032 0.0138 0.1936
Trypanosoma brucei DNA polymerase eta, putative 0.0061 0.0513 0.7102
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0339 0.066
Loa Loa (eye worm) hypothetical protein 0.0061 0.0513 0.1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0499 0.0972
Brugia malayi hypothetical protein 0.0232 0.2742 0.5344
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0023 0.0021 0.0301
Schistosoma mansoni hypothetical protein 0.0041 0.0253 0.0494
Loa Loa (eye worm) hypothetical protein 0.0243 0.2884 0.5622
Schistosoma mansoni transcription factor btf3 0.0076 0.0713 0.139
Trypanosoma cruzi metallo-peptidase, Clan MC, Family M14 0.0035 0.018 0.2526
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0713 0.1968
Loa Loa (eye worm) hypothetical protein 0.0041 0.0253 0.0494
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0021 0.0301
Loa Loa (eye worm) hypothetical protein 0.0146 0.1629 0.3175
Trypanosoma brucei heat shock protein, putative 0.0032 0.0138 0.1686
Entamoeba histolytica hypothetical protein 0.0113 0.1195 0.3338
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.3538 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0021 0.0049
Echinococcus multilocularis subfamily M14A unassigned peptidase 0.0148 0.165 0.165
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0054 0.0091
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0023 0.0021 0.0042
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0035 0.018 0.0451
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0513 0.7102
Brugia malayi Zinc carboxypeptidase family protein 0.0035 0.018 0.0351
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0023 0.0021 0.0301
Plasmodium falciparum basic transcription factor 3b, putative 0.0076 0.0713 1
Leishmania major heat shock protein 83-1 0.0032 0.0138 0.1936
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0025 0.0054 0.0054
Onchocerca volvulus 0.0148 0.165 1
Plasmodium vivax phosphodiesterase gamma, putative 0.0023 0.0021 0.0301
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0023 0.0021 0.0301
Toxoplasma gondii PAN domain-containing protein 0.0023 0.0022 0.0049
Onchocerca volvulus 0.0023 0.0022 0.013
Schistosoma mansoni tar DNA-binding protein 0.0211 0.2473 0.4819
Toxoplasma gondii subtilisin SUB12 0.0023 0.0022 0.0049
Loa Loa (eye worm) hypothetical protein 0.0416 0.5131 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0205 0.0521
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0042
Loa Loa (eye worm) PAN domain-containing protein 0.0023 0.0022 0.0042
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0023 0.0021 0.0301
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0205 0.0205
Loa Loa (eye worm) hypothetical protein 0.0031 0.0127 0.0248
Brugia malayi GH02984p 0.0416 0.5131 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0023 0.0021 0.0042
Leishmania major heat shock protein 83-1 0.0032 0.0138 0.1936
Giardia lamblia Fructose-bisphosphate aldolase 0.0293 0.3538 1
Leishmania major heat shock protein 83-1 0.0032 0.0138 0.1936
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0138 0.033
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0061 0.0513 0.0513
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0021 0.0049
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0061 0.0513 0.1
Leishmania major hypothetical protein, conserved 0.0023 0.0021 0.0301
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0021 0.0301
Schistosoma mansoni heat shock protein 0.0032 0.0138 0.0269
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0023 0.0021 0.0021
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0023 0.0021 0.0042
Onchocerca volvulus 0.0023 0.0022 0.0133
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0023 0.0021 0.0021
Onchocerca volvulus Huntingtin homolog 0.0146 0.1629 0.9872
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0023 0.0021 0.0021
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0023 0.0021 0.0021
Brugia malayi PAN domain containing protein 0.0023 0.0022 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0268 0.356
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0023 0.0021 0.0021
Schistosoma mansoni transcription factor LCR-F1 0.0113 0.1195 0.233
Loa Loa (eye worm) PDE1B protein 0.0023 0.0021 0.0042
Brugia malayi Inositol-1 0.0037 0.0205 0.04
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0023 0.0021 0.0042
Onchocerca volvulus Huntingtin homolog 0.0146 0.1629 0.9872
Leishmania major heat shock protein 83-1 0.0032 0.0138 0.1936
Echinococcus granulosus geminin 0.0203 0.2359 0.2359
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0023 0.0021 0.0301
Leishmania major heat shock protein 83-1 0.0032 0.0138 0.1936
Schistosoma mansoni tar DNA-binding protein 0.0211 0.2473 0.4819
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0023 0.0021 0.0301
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.3538 1
Brugia malayi intermediate filament protein 0.0116 0.1233 0.2404
Brugia malayi beta-NAC-like protein 0.0076 0.0713 0.139
Schistosoma mansoni lamin 0.0116 0.1233 0.2404
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0513 0.7102
Toxoplasma gondii microneme protein, putative 0.0023 0.0022 0.0049
Loa Loa (eye worm) zinc carboxypeptidase 0.0066 0.0584 0.1139
Toxoplasma gondii microneme protein MIC4 0.0023 0.0022 0.0049
Leishmania major heat shock protein 83-1 0.0032 0.0138 0.1936
Schistosoma mansoni tar DNA-binding protein 0.0211 0.2473 0.4819
Echinococcus multilocularis high affinity choline transporter 1 0.0416 0.5131 0.5131
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0268 0.356
Mycobacterium ulcerans heat shock protein 90 0.0025 0.0054 0.0202
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0035 0.018 0.0451
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0021 0.0301
Echinococcus multilocularis 0.0035 0.018 0.018
Brugia malayi Zinc carboxypeptidase family protein 0.0035 0.018 0.0351
Echinococcus granulosus subfamily M14A unassigned peptidase 0.0148 0.165 0.165
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0153 0.1709 0.333
Loa Loa (eye worm) hypothetical protein 0.0035 0.018 0.0351
Brugia malayi PAN domain containing protein 0.0023 0.0022 0.0042
Echinococcus granulosus tar DNA binding protein 0.0211 0.2473 0.2473
Brugia malayi Zinc carboxypeptidase family protein 0.0035 0.018 0.0351
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0021 0.0049
Trypanosoma brucei heat shock protein, putative 0.0032 0.0138 0.1686
Loa Loa (eye worm) hypothetical protein 0.0035 0.018 0.0351
Trypanosoma brucei unspecified product 0.0042 0.0268 0.356
Trypanosoma brucei heat shock protein, putative 0.0032 0.0138 0.1686
Brugia malayi LD47325p 0.0031 0.0127 0.0248
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0205 0.0523
Loa Loa (eye worm) intermediate filament protein 0.0116 0.1233 0.2404
Schistosoma mansoni peptidase 0.0035 0.018 0.0351
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0022 0.0307
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0205 0.1172
Entamoeba histolytica hypothetical protein 0.0113 0.1195 0.3338
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0023 0.0021 0.0301
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0023 0.0021 0.0021
Toxoplasma gondii PAN domain-containing protein 0.0023 0.0022 0.0049
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0023 0.0022 0.0049
Onchocerca volvulus 0.0148 0.165 1
Echinococcus multilocularis dna polymerase kappa 0.0061 0.0513 0.0513
Leishmania major heat shock protein 83-1 0.0032 0.0138 0.1936
Schistosoma mansoni family M14 non-peptidase homologue (M14 family) 0.0035 0.018 0.0351
Giardia lamblia Grp94/Hsp90 0.0025 0.0054 0.0091
Toxoplasma gondii PAN domain-containing protein 0.0023 0.0022 0.0049
Brugia malayi Endoplasmin precursor 0.0032 0.0138 0.0269
Loa Loa (eye worm) ICD-1 protein 0.0076 0.0713 0.139
Trichomonas vaginalis DNA polymerase eta, putative 0.0061 0.0513 0.1398
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0113 0.1195 0.1195
Onchocerca volvulus 0.0023 0.0022 0.013
Schistosoma mansoni DNA polymerase eta 0.0061 0.0513 0.1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0021 0.0049
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0042
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.3538 1
Echinococcus granulosus heat shock protein 0.0032 0.0138 0.0138
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0113 0.1195 0.1195
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0202 0.2354 0.2354
Loa Loa (eye worm) zinc carboxypeptidase 0.0035 0.018 0.0351
Trypanosoma cruzi transcription factor btf3, putative 0.0076 0.0713 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0293 0.3538 1
Echinococcus multilocularis transcription factor btf3 0.0076 0.0713 0.0713
Echinococcus granulosus solute carrier family 5 0.0046 0.032 0.032
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0042
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0153 0.1709 0.1709
Schistosoma mansoni subfamily M14A unassigned peptidase (M14 family) 0.0148 0.165 0.3216
Trypanosoma cruzi metallo-peptidase, Clan MC, Family M14, putative 0.0035 0.018 0.2526
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0054 0.0091
Toxoplasma gondii heat shock protein 90, putative 0.0032 0.0138 0.0317
Plasmodium falciparum phosphodiesterase delta, putative 0.0023 0.0021 0.0301
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.3538 1
Trypanosoma brucei metallo-peptidase, Clan MC, Family M14, putative 0.0035 0.018 0.2294
Schistosoma mansoni peptidase 0.0035 0.018 0.0351
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.0513 0.7189
Echinococcus multilocularis heat shock protein 90 0.0025 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0054 0.0424 0.0827
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0205 1
Leishmania major heat shock protein 83-1 0.0032 0.0138 0.1936
Leishmania major heat shock protein 83-1 0.0032 0.0138 0.1936
Echinococcus granulosus high affinity choline transporter 1 0.0416 0.5131 0.5131
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0022 0.0307
Onchocerca volvulus 0.0023 0.0022 0.013
Leishmania major zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 0.0035 0.018 0.2526
Onchocerca volvulus 0.0116 0.1233 0.7474
Onchocerca volvulus 0.0023 0.0022 0.013
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0043
Trypanosoma brucei unspecified product 0.0042 0.0268 0.356
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0046 0.032 0.0733
Loa Loa (eye worm) hypothetical protein 0.0145 0.1605 0.3129
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0785 0.9938 0.9938
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0153 0.1709 0.1709
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0025 0.0054 0.0751
Loa Loa (eye worm) hypothetical protein 0.0035 0.018 0.0351
Loa Loa (eye worm) PAN domain-containing protein 0.0023 0.0022 0.0042
Brugia malayi Zinc carboxypeptidase family protein 0.0035 0.018 0.0351
Echinococcus multilocularis muscleblind protein 1 0.0145 0.1605 0.1605
Toxoplasma gondii zinc carboxypeptidase, putative 0.0035 0.018 0.0413
Leishmania major heat shock protein 83-1 0.0032 0.0138 0.1936
Onchocerca volvulus 0.0023 0.0022 0.013
Echinococcus granulosus dna polymerase kappa 0.0061 0.0513 0.0513
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0023 0.0021 0.0021
Brugia malayi PAN domain containing protein 0.0023 0.0022 0.0042
Brugia malayi PAN domain containing protein 0.0023 0.0022 0.0042
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0021 0.0049
Toxoplasma gondii NAC domain-containing protein 0.0076 0.0713 0.1637
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.3538 1
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0023 0.0021 0.0042
Brugia malayi RNA binding protein 0.0211 0.2473 0.4819
Schistosoma mansoni survival motor neuron protein 0.0047 0.0339 0.066
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0042
Schistosoma mansoni peptidase 0.0035 0.018 0.0351
Schistosoma mansoni heat shock protein 0.0032 0.0138 0.0269
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0205 0.2876
Brugia malayi RNA recognition motif domain containing protein 0.0211 0.2473 0.4819
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0155 0.0849
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0035 0.018 0.0451
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0046 0.032 0.032
Schistosoma mansoni hypothetical protein 0.0047 0.0339 0.066
Brugia malayi Zinc carboxypeptidase family protein 0.0066 0.0584 0.1139
Brugia malayi ImpB/MucB/SamB family protein 0.0061 0.0513 0.1
Brugia malayi PAN domain containing protein 0.0023 0.0022 0.0042
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0021 0.0049
Echinococcus multilocularis lamin 0.0116 0.1233 0.1233
Toxoplasma gondii PAN domain-containing protein 0.0356 0.4358 1
Treponema pallidum fructose-bisphosphate aldolase 0.0293 0.3538 1
Onchocerca volvulus 0.0116 0.1233 0.7474
Loa Loa (eye worm) hypothetical protein 0.0116 0.1233 0.2404
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0046 0.032 0.032
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0021 0.0049
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0023 0.0021 0.0042
Entamoeba histolytica hypothetical protein 0.0113 0.1195 0.3338
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0056 0.0452 0.0452
Loa Loa (eye worm) hypothetical protein 0.0023 0.0021 0.0042
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0035 0.018 0.0451
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0046 0.032 0.032
Plasmodium falciparum phosphodiesterase gamma, putative 0.0023 0.0021 0.0301
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0205 0.0205
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0025 0.0054 0.0202
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0293 0.3538 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0513 0.7102
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0023 0.0021 0.0042
Onchocerca volvulus 0.0148 0.165 1
Plasmodium falciparum heat shock protein 90 0.0032 0.0138 0.1936
Loa Loa (eye worm) hypothetical protein 0.0114 0.1206 0.235
Leishmania major DNA polymerase eta, putative 0.0061 0.0513 0.7189
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0205 0.2876
Leishmania major zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 0.0035 0.018 0.2526
Leishmania major zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 0.0035 0.018 0.2526
Leishmania major heat shock protein 83-1 0.0032 0.0138 0.1936
Giardia lamblia Nuclear ATP/GTP-binding protein 0.0035 0.018 0.0451
Echinococcus multilocularis muscleblind protein 0.0145 0.1605 0.1605
Brugia malayi Muscleblind-like protein 0.0145 0.1605 0.3129
Schistosoma mansoni terminal deoxycytidyl transferase 0.0061 0.0513 0.1
Echinococcus multilocularis geminin 0.0203 0.2359 0.2359
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0023 0.0021 0.0021
Toxoplasma gondii PAN domain-containing protein 0.0023 0.0022 0.0049
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0035 0.018 0.0451
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0021 0.0049
Loa Loa (eye worm) PAN domain-containing protein 0.0023 0.0022 0.0042
Onchocerca volvulus 0.0023 0.0022 0.013
Loa Loa (eye worm) hypothetical protein 0.0054 0.0424 0.0827
Echinococcus granulosus transcription factor btf3 0.0076 0.0713 0.0713
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0023 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0056 0.0452 0.0881
Trypanosoma cruzi heat shock protein 85, putative 0.0025 0.0054 0.0751
Trypanosoma brucei metallo-peptidase, Clan MC, Family M14, putative 0.0035 0.018 0.2294
Trypanosoma cruzi DNA polymerase eta, putative 0.0061 0.0513 0.7189
Toxoplasma gondii microneme protein MIC17C 0.0023 0.0022 0.0049
Toxoplasma gondii microneme protein MIC17B 0.0023 0.0022 0.0049
Trypanosoma brucei heat shock protein, putative 0.0032 0.0138 0.1686
Echinococcus granulosus dna polymerase eta 0.0061 0.0513 0.0513
Schistosoma mansoni tar DNA-binding protein 0.0211 0.2473 0.4819
Plasmodium vivax endoplasmin, putative 0.0032 0.0138 0.1936
Loa Loa (eye worm) hypothetical protein 0.0035 0.018 0.0351
Echinococcus multilocularis Zinc carboxypeptidase family protein 0.0035 0.018 0.018
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0023 0.0021 0.0042
Leishmania major heat shock protein 83-1 0.0032 0.0138 0.1936
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0205 0.0523
Schistosoma mansoni lamin 0.0116 0.1233 0.2404
Schistosoma mansoni hypothetical protein 0.0203 0.2359 0.4598
Toxoplasma gondii PAN domain-containing protein 0.0356 0.4358 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.032 0.0623
Entamoeba histolytica hypothetical protein 0.0076 0.0713 0.1967
Schistosoma mansoni metallocarboxypeptidase D peptidase unit 2 (M14 family) 0.0035 0.018 0.0351
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0021 0.0049
Echinococcus granulosus sodium:glucose cotransporter 0.0046 0.032 0.032
Echinococcus granulosus cytosolic carboxypeptidase 1 0.0035 0.018 0.018
Leishmania major heat shock protein 83-1 0.0032 0.0138 0.1936
Loa Loa (eye worm) zinc carboxypeptidase 0.0035 0.018 0.0351
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0205 0.2656
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0021 0.0049
Leishmania major heat shock protein 83-1 0.0032 0.0138 0.1936
Entamoeba histolytica deoxycytidyl transferase, putative 0.0061 0.0513 0.1397
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0021 0.0049
Toxoplasma gondii microneme protein MIC17A 0.0023 0.0022 0.0049
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0268 0.356
Echinococcus multilocularis heat shock protein 90 0.0032 0.0138 0.0138
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0061 0.0513 0.1398
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0023 0.0021 0.0021
Loa Loa (eye worm) PAN domain-containing protein 0.0023 0.0022 0.0042
Brugia malayi Carboxypeptidase A2 precursor 0.0035 0.018 0.0351
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0035 0.018 0.0451
Trypanosoma cruzi Carboxypeptidase-like protein 0.0035 0.018 0.2526
Brugia malayi PAN domain containing protein 0.0023 0.0022 0.0042
Giardia lamblia DINP protein human, muc B family 0.0061 0.0513 0.1398
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0042
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0021 0.0049
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.2742 0.2742
Trypanosoma brucei unspecified product 0.0061 0.0513 0.7102
Trypanosoma cruzi metallo-peptidase, Clan MC, Family M14, putative 0.0035 0.018 0.2526
Schistosoma mansoni hypothetical protein 0.0113 0.1195 0.233
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0713 0.1968
Brugia malayi Zinc carboxypeptidase family protein 0.0035 0.018 0.0351
Echinococcus granulosus cytosolic carboxypeptidase protein 5 0.0035 0.018 0.018
Loa Loa (eye worm) inositol-1 0.0037 0.0205 0.04
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0023 0.0021 0.0301
Giardia lamblia Heat shock protein HSP 90-alpha 0.0025 0.0054 0.0091
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0153 0.1709 0.333
Brugia malayi PAN domain containing protein 0.0023 0.0022 0.0042
Onchocerca volvulus Carboxypeptidase D homolog 0.0066 0.0584 0.354
Onchocerca volvulus 0.0046 0.032 0.1937
Echinococcus granulosus sodium:glucose cotransporter 2 0.0046 0.032 0.032
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0022 0.0307
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.0513 0.7102
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0021 0.0049
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0143 0.1587 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0513 0.7102
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0205 0.0471
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.079 1 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0023 0.0021 0.0042
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0153 0.1709 0.1709

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Inhibition of carboxypeptidase A at 10 ug/ml ChEMBL. 11000037
Activity (binding) Inhibition of human dual specificity protein phosphatase VHR expressed in Escherichia coli JM109 at 100 ug/mL ChEMBL. 11520225
Activity (binding) Inhibition of human dual specificity protein phosphatase Cdc25B expressed in Escherichia coli BL21 (DE3) at 100 ug/mL ChEMBL. 11520225
IC50 (binding) NA 0 ug ml-1 Ability to inhibit Carboxypeptidase A from cyanobacterium Oscillatoria agardhii (microalgae) at a concentration of 50 ug/mL; No Activity ChEMBL. 10340607
IC50 (binding) = 0.0015 uM Inhibition of human activated TAFI incubated for 15 mins by microtiter plate reader based assay ChEMBL. 25990761
IC50 (binding) = 0.35 uM Inhibition of factor2a (unknown origin) ChEMBL. 25990761
IC50 (binding) = 1.1 uM Inhibition of CPA (unknown origin) ChEMBL. 25990761
IC50 (binding) = 2.7 uM Inhibition of CPN (unknown origin) ChEMBL. 25990761
IC50 (binding) = 3.9 uM Inhibition of factor11a (unknown origin) ChEMBL. 25990761
IC50 (binding) = 35 uM Inhibition of factor7a (unknown origin) ChEMBL. 25990761
IC50 (binding) = 38 uM Inhibition of factor10a (unknown origin) ChEMBL. 25990761
Inhibition (binding) Inhibition of trypsin (unknown origin) using benzoyl-L-arginine-p-nitroanilide hydrochloride as substrate preincubated at 45.5 uM for 5 mins before substrate addition measured after 30 mins ChEMBL. 24261937
Inhibition (binding) Inhibition of thrombin (unknown origin) using z-Gly-Pro-Arg-4MbetaNA-acetate as substrate preincubated at 45.5 uM for 20 mins before substrate addition measured after 20 mins ChEMBL. 24261937

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

5 literature references were collected for this gene.

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