Detailed information for compound 312010

Basic information

Technical information
  • TDR Targets ID: 312010
  • Name: 1-[2-[(4-benzylpiperidin-1-yl)methyl]cyclohex yl]-3-(3-methoxyphenyl)urea
  • MW: 435.602 | Formula: C27H37N3O2
  • H donors: 2 H acceptors: 1 LogP: 5.35 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)NC(=O)NC1CCCCC1CN1CCC(CC1)Cc1ccccc1
  • InChi: 1S/C27H37N3O2/c1-32-25-12-7-11-24(19-25)28-27(31)29-26-13-6-5-10-23(26)20-30-16-14-22(15-17-30)18-21-8-3-2-4-9-21/h2-4,7-9,11-12,19,22-23,26H,5-6,10,13-18,20H2,1H3,(H2,28,29,31)
  • InChiKey: FSIZZJSQRKUBMT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[2-[(4-benzyl-1-piperidyl)methyl]cyclohexyl]-3-(3-methoxyphenyl)urea
  • 1-[2-[(4-benzyl-1-piperidinyl)methyl]cyclohexyl]-3-(3-methoxyphenyl)urea
  • 1-(3-methoxyphenyl)-3-[2-[[4-(phenylmethyl)piperidin-1-yl]methyl]cyclohexyl]urea
  • 1-[2-[(4-benzylpiperidino)methyl]cyclohexyl]-3-(3-methoxyphenyl)urea
  • 3-(3-methoxyphenyl)-1-[2-[[4-(phenylmethyl)piperidin-1-yl]methyl]cyclohexyl]urea
  • 3-(3-methoxyphenyl)-1-[2-[[4-(phenylmethyl)-1-piperidyl]methyl]cyclohexyl]urea
  • 3-(3-methoxyphenyl)-1-[2-[[4-(phenylmethyl)-1-piperidinyl]methyl]cyclohexyl]urea
  • 1-[2-[[4-(benzyl)-1-piperidyl]methyl]cyclohexyl]-3-(3-methoxyphenyl)urea

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens chemokine (C-C motif) receptor 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0123 0.1084 0.1533
Echinococcus granulosus lipoxygenase domain containing protein 0.0103 0.0869 0.1179
Loa Loa (eye worm) hypothetical protein 0.0192 0.1842 0.2618
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0139 0.1257 0.2119
Echinococcus granulosus fatty acid amide hydrolase 1 0.0098 0.0817 0.1107
Loa Loa (eye worm) hypothetical protein 0.0058 0.037 0.051
Trypanosoma cruzi major cysteine proteinase, putative 0.0059 0.038 0.3698
Loa Loa (eye worm) hypothetical protein 0.0105 0.0886 0.1249
Schistosoma mansoni single-minded 0.0057 0.0361 0.0585
Brugia malayi tailless protein 0.0058 0.037 0.0503
Schistosoma mansoni nAChR subunit 0.0064 0.0436 0.0713
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0139 0.1257 0.1755
Brugia malayi Nuclear hormone receptor-like 1 0.0065 0.0447 0.0612
Loa Loa (eye worm) hypothetical protein 0.0139 0.1257 0.1781
Brugia malayi amidase 0.0098 0.0817 0.1143
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0324 0.0521
Brugia malayi RNA, U transporter 1 0.0085 0.0671 0.0934
Schistosoma mansoni fatty-acid amide hydrolase 0.0098 0.0817 0.1365
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0123 0.1084 0.1526
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0049 0.0275 0.0373
Schistosoma mansoni hypothetical protein 0.0037 0.014 0.0207
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0324 0.0521
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0123 0.1084 0.1479
Schistosoma mansoni lipoxygenase 0.0557 0.5863 1
Brugia malayi orphan nuclear receptor NR2E1 0.0058 0.037 0.0503
Loa Loa (eye worm) latrophilin receptor protein 2 0.0037 0.014 0.018
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0139 0.1257 0.1719
Schistosoma mansoni nuclear receptor nhr-48 0.0058 0.037 0.0601
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0932 1 1
Loa Loa (eye worm) TAR-binding protein 0.014 0.1276 0.1807
Brugia malayi Peroxidasin 0.0105 0.0886 0.1242
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.005 0.0279 0.0445
Loa Loa (eye worm) hypothetical protein 0.0139 0.1257 0.1781
Schistosoma mansoni jun-related protein 0.0234 0.2307 0.3915
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0019 0.0008
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0063 0.043 0.0589
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0345 0.0474
Brugia malayi Nuclear hormone receptor-like 1 0.0065 0.0447 0.0612
Schistosoma mansoni hypothetical protein 0.0037 0.014 0.0207
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0123 0.1084 0.151
Brugia malayi Serotonin receptor 0.0458 0.4776 0.6816
Loa Loa (eye worm) hypothetical protein 0.0075 0.0554 0.0773
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0058 0.037 0.0497
Entamoeba histolytica hypothetical protein 0.0036 0.0133 0.2403
Schistosoma mansoni nuclear receptor 0.0058 0.037 0.0601
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0139 0.1257 0.1774
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0123 0.1084 0.1823
Plasmodium falciparum importin beta, putative 0.003 0.0062 0.0411
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0201 0.1946 0.2767
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.005 0.0053
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0239 0.2359 0.3248
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.032 0.3257 0.4644
Loa Loa (eye worm) hypothetical protein 0.0088 0.0697 0.0978
Echinococcus granulosus nAChR subunit 0.0139 0.1257 0.1719
Leishmania major cathepsin L-like protease 0.0075 0.0557 0.5414
Echinococcus multilocularis GPCR, family 2 0.0037 0.014 0.0171
Echinococcus granulosus FTZ F1 alpha 0.0123 0.1084 0.1479
Echinococcus multilocularis Ankyrin 0.005 0.0279 0.0369
Echinococcus multilocularis nAChR subunit 0.0075 0.0554 0.0758
Schistosoma mansoni nAChR subunit 0.0139 0.1257 0.2119
Loa Loa (eye worm) hypothetical protein 0.0103 0.0869 0.1224
Brugia malayi Latrophilin receptor protein 2 0.0037 0.014 0.0173
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0139 0.1257 0.1719
Loa Loa (eye worm) hypothetical protein 0.0064 0.0436 0.0604
Loa Loa (eye worm) hypothetical protein 0.0139 0.1257 0.1781
Onchocerca volvulus Peroxidasin homolog 0.0105 0.0886 0.3873
Loa Loa (eye worm) hypothetical protein 0.0139 0.1257 0.1781
Echinococcus multilocularis FTZ F1 alpha 0.0123 0.1084 0.151
Mycobacterium ulcerans proteasome PrcA 0.0932 1 1
Loa Loa (eye worm) hypothetical protein 0.0139 0.1257 0.1781
Schistosoma mansoni hypothetical protein 0.0049 0.0275 0.0437
Loa Loa (eye worm) hypothetical protein 0.0139 0.1257 0.1781
Loa Loa (eye worm) hypothetical protein 0.0105 0.0886 0.1249
Schistosoma mansoni neurotransmitter gated ion channel 0.0075 0.0554 0.0915
Onchocerca volvulus 0.0139 0.1257 0.5534
Onchocerca volvulus 0.0105 0.0886 0.3873
Brugia malayi Cation transporter family protein 0.0139 0.1257 0.1774
Schistosoma mansoni nAChR subunit 0.0139 0.1257 0.2119
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0139 0.1257 0.1774
Brugia malayi Pre-SET motif family protein 0.0201 0.1946 0.2761
Brugia malayi hypothetical protein 0.0058 0.037 0.0503
Echinococcus granulosus carbonic anhydrase 0.0027 0.0028 0.0012
Loa Loa (eye worm) hypothetical protein 0.0065 0.0447 0.0619
Echinococcus granulosus jun protein 0.0288 0.29 0.4
Loa Loa (eye worm) hypothetical protein 0.0098 0.0817 0.1149
Echinococcus multilocularis netrin receptor unc 5 0.0049 0.0275 0.0362
Loa Loa (eye worm) hypothetical protein 0.0545 0.5736 0.8193
Brugia malayi ecdysteroid receptor 0.0123 0.1084 0.1526
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0123 0.1084 0.1533
Schistosoma mansoni RAR-like nuclear receptor 0.0123 0.1084 0.1823
Loa Loa (eye worm) GABA receptor subunit 0.0075 0.0554 0.0773
Loa Loa (eye worm) hypothetical protein 0.0103 0.0869 0.1224
Brugia malayi Cation transporter family protein 0.0139 0.1257 0.1774
Loa Loa (eye worm) acetylcholine receptor protein 0.0064 0.0436 0.0604
Loa Loa (eye worm) hypothetical protein 0.0058 0.037 0.051
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0463 0.4831 0.8234
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.0324 0.0432
Onchocerca volvulus 0.0057 0.0356 0.1505
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0027 0.0028 0.0013
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.014 0.1276 0.1807
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0139 0.1257 0.1755
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.1099 0.1554
Schistosoma mansoni thyroid hormone receptor 0.0123 0.1084 0.1823
Schistosoma mansoni hypothetical protein 0.032 0.3257 0.5541
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0288 0.29 0.4
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0065 0.0447 0.0731
Brugia malayi nuclear receptor NHR-88 0.0123 0.1084 0.1526
Brugia malayi hypothetical protein 0.0065 0.0447 0.0612
Loa Loa (eye worm) hypothetical protein 0.0049 0.0275 0.0373
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0123 0.1084 0.1479
Loa Loa (eye worm) hypothetical protein 0.0075 0.0554 0.0773
Schistosoma mansoni importin beta-1 0.003 0.0062 0.0074
Loa Loa (eye worm) nuclear receptor NHR-67 0.0058 0.037 0.051
Echinococcus granulosus lipoxygenase domain containing protein 0.0103 0.0869 0.1179
Schistosoma mansoni neurotransmitter gated ion channel 0.0064 0.0436 0.0713
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0123 0.1084 0.1533
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0123 0.1084 0.151
Schistosoma mansoni carbonic anhydrase-related 0.0027 0.0028 0.0015
Brugia malayi Calcitonin receptor-like protein seb-1 0.0117 0.1021 0.1435
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0064 0.0436 0.0578
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0557 0.5117
Loa Loa (eye worm) hypothetical protein 0.0139 0.1257 0.1781
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0123 0.1084 0.1526
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0123 0.1084 0.1823
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0058 0.037 0.0497
Echinococcus granulosus nuclear factor of activated T cells 5 0.0252 0.251 0.3458
Onchocerca volvulus 0.0123 0.1084 0.476
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0139 0.1257 0.1719
Entamoeba histolytica hypothetical protein 0.0036 0.0133 0.2403
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0557 0.5117
Onchocerca volvulus 0.0064 0.0436 0.1862
Onchocerca volvulus 0.0226 0.222 0.9836
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0139 0.1257 0.1774
Loa Loa (eye worm) hypothetical protein 0.0065 0.0447 0.0619
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0117 0.1021 0.1435
Loa Loa (eye worm) hypothetical protein 0.0105 0.0886 0.1249
Loa Loa (eye worm) hypothetical protein 0.0123 0.1084 0.1533
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0557 0.5117
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0075 0.0554 0.0915
Brugia malayi RNA binding protein 0.014 0.1276 0.1801
Echinococcus granulosus importin subunit beta 1 0.003 0.0062 0.006
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0139 0.1257 0.1719
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0058 0.037 0.0503
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.0324 0.0432
Brugia malayi hypothetical protein 0.0064 0.0436 0.0597
Loa Loa (eye worm) hypothetical protein 0.0088 0.0697 0.0978
Brugia malayi Cytochrome P450 family protein 0.0107 0.0913 0.1281
Loa Loa (eye worm) hypothetical protein 0.0105 0.0886 0.1249
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0037 0.014 0.0173
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0054 0.0324 0.0443
Schistosoma mansoni nAChR subunit 0.0139 0.1257 0.2119
Schistosoma mansoni hypothetical protein 0.0199 0.1921 0.3255
Echinococcus multilocularis carbonic anhydrase II 0.0118 0.1029 0.1431
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0098 0.0817 0.1131
Schistosoma mansoni carbonic anhydrase-related 0.0027 0.0028 0.0015
Brugia malayi nuclear receptor RXR 0.0058 0.037 0.0503
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0118 0.1029 0.1447
Loa Loa (eye worm) RNA binding protein 0.014 0.1276 0.1807
Onchocerca volvulus 0.0075 0.0554 0.239
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.005 0.0053
Loa Loa (eye worm) hypothetical protein 0.028 0.2814 0.4009
Onchocerca volvulus 0.0105 0.0886 0.3873
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0065 0.0447 0.0593
Schistosoma mansoni tar DNA-binding protein 0.014 0.1276 0.2151
Brugia malayi nuclear receptor RXR 0.0065 0.0447 0.0612
Echinococcus granulosus thyroid hormone receptor alpha 0.0058 0.037 0.0487
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0123 0.1084 0.1526
Onchocerca volvulus Dual oxidase homolog 0.0105 0.0886 0.3873
Brugia malayi hypothetical protein 0.0103 0.0869 0.1217
Schistosoma mansoni hypothetical protein 0.0027 0.0028 0.0015
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0063 0.043 0.0237
Schistosoma mansoni carbonic anhydrase 0.0027 0.0028 0.0015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0557 0.5117
Brugia malayi PAS domain containing protein 0.0057 0.0361 0.049
Onchocerca volvulus 0.0064 0.0436 0.1862
Echinococcus multilocularis snurportin 1 0.032 0.3257 0.459
Onchocerca volvulus 0.0042 0.0198 0.0798
Brugia malayi hypothetical protein 0.0064 0.0436 0.0597
Brugia malayi TAR-binding protein 0.014 0.1276 0.1801
Schistosoma mansoni nAChR subunit 0.0139 0.1257 0.2119
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0123 0.1084 0.1526
Echinococcus multilocularis glycine receptor subunit beta 0.0139 0.1257 0.1755
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0139 0.1257 0.1774
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0037 0.014 0.0171
Brugia malayi Cation transporter family protein 0.0139 0.1257 0.1774
Schistosoma mansoni steroid hormone receptor ad4bp 0.0123 0.1084 0.1823
Plasmodium vivax importin-beta 2, putative 0.003 0.0062 0.0154
Echinococcus multilocularis survival motor neuron protein 1 0.0278 0.2789 0.3927
Loa Loa (eye worm) hypothetical protein 0.0037 0.014 0.018
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0123 0.1084 0.1526
Loa Loa (eye worm) ACC-1 protein 0.0139 0.1257 0.1781
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0324 0.0521
Loa Loa (eye worm) hypothetical protein 0.0064 0.0436 0.0604
Brugia malayi follicle stimulating hormone receptor 0.0236 0.2329 0.331
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0057 0.0356 0.0482
Echinococcus multilocularis carbonic anhydrase 0.0027 0.0028 0.0012
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0063 0.043 0.0237
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0123 0.1084 0.1479
Schistosoma mansoni aryl hydrocarbon receptor 0.0057 0.0361 0.0585
Onchocerca volvulus Protein ultraspiracle homolog 0.0123 0.1084 0.476
Brugia malayi Nuclear hormone receptor E75 0.0058 0.037 0.0503
Loa Loa (eye worm) hypothetical protein 0.0064 0.0436 0.0604
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0075 0.0554 0.0766
Schistosoma mansoni acetylcholine receptor subunit beta 0.0064 0.0436 0.0713
Loa Loa (eye worm) hypothetical protein 0.0058 0.037 0.051
Loa Loa (eye worm) animal heme peroxidase 0.0105 0.0886 0.1249
Onchocerca volvulus Peroxidasin homolog 0.0105 0.0886 0.3873
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0139 0.1257 0.2119
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0139 0.1257 0.1774
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0123 0.1084 0.1526
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.005 0.635
Schistosoma mansoni carbonic anhydrase-related 0.0027 0.0028 0.0015
Echinococcus multilocularis lipoxygenase domain containing protein 0.0103 0.0869 0.1204
Schistosoma mansoni survival motor neuron protein 0.0057 0.0356 0.0576
Onchocerca volvulus 0.0105 0.0886 0.3873
Plasmodium vivax multidomain scavenger receptor, putative 0.0103 0.0869 1
Echinococcus granulosus snurportin 1 0.032 0.3257 0.4495
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0139 0.1257 0.1774
Loa Loa (eye worm) hypothetical protein 0.0139 0.1257 0.1781
Echinococcus granulosus death domain containing protein 0.0049 0.0275 0.0355
Loa Loa (eye worm) hypothetical protein 0.0139 0.1257 0.1781
Trypanosoma cruzi cysteine peptidase, putative 0.0075 0.0557 0.5414
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0139 0.1257 0.1774
Brugia malayi hypothetical protein 0.0064 0.0436 0.0597
Echinococcus granulosus tar DNA binding protein 0.014 0.1276 0.1745
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0139 0.1257 0.1755
Echinococcus granulosus carbonic anhydrase II 0.0118 0.1029 0.1402
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0557 0.5117
Brugia malayi Animal haem peroxidase family protein 0.0105 0.0886 0.1242
Schistosoma mansoni neurotransmitter gated ion channel 0.0064 0.0436 0.0713
Onchocerca volvulus 0.0058 0.037 0.1568
Loa Loa (eye worm) hypothetical protein 0.0058 0.037 0.051
Plasmodium falciparum LCCL domain-containing protein 0.0103 0.0869 1
Onchocerca volvulus 0.0103 0.0869 0.3797
Loa Loa (eye worm) hypothetical protein 0.0064 0.0436 0.0604
Trypanosoma brucei carbonic anhydrase-like protein 0.0118 0.1029 1
Brugia malayi Blistered cuticle protein 3 0.0105 0.0886 0.1242
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0058 0.037 0.1568
Schistosoma mansoni nuclear hormone receptor 0.0123 0.1084 0.1823
Schistosoma mansoni peroxidasin 0.0105 0.0886 0.1483
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0037 0.014 0.0168
Brugia malayi hypothetical protein 0.0278 0.2789 0.397
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0139 0.1257 0.1719
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0054 0.0324 0.0436
Echinococcus multilocularis carbonic anhydrase 0.0027 0.0028 0.0012
Schistosoma mansoni netrin receptor unc5 0.0049 0.0275 0.0437
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0123 0.1084 0.1479
Treponema pallidum sodium- and chloride- dependent transporter 0.0088 0.0697 0.5
Echinococcus granulosus ecdysone induced protein 78C 0.0123 0.1084 0.1479
Schistosoma mansoni tar DNA-binding protein 0.014 0.1276 0.2151
Loa Loa (eye worm) norepinephrine transporter 0.0088 0.0697 0.0978
Loa Loa (eye worm) LGC-31 protein 0.0139 0.1257 0.1781
Loa Loa (eye worm) hypothetical protein 0.0139 0.1257 0.1781
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0123 0.1084 0.1533
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0139 0.1257 0.1774
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0139 0.1257 0.1781
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.005 0.0053
Trypanosoma cruzi cruzipain precursor, putative 0.0075 0.0557 0.5414
Schistosoma mansoni hypothetical protein 0.0057 0.0356 0.0576
Loa Loa (eye worm) hypothetical protein 0.0058 0.037 0.051
Loa Loa (eye worm) hypothetical protein 0.008 0.0613 0.0858
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0139 0.1257 0.2119
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0139 0.1257 0.1774
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0252 0.251 0.3532
Loa Loa (eye worm) serotonin transporter b 0.0088 0.0697 0.0978
Onchocerca volvulus 0.0029 0.005 0.0137
Echinococcus granulosus glycine receptor subunit alpha 1 0.0139 0.1257 0.1719
Loa Loa (eye worm) doublecortin family protein 0.0103 0.0869 0.1224
Brugia malayi conserved hypotetical protein 0.0058 0.037 0.0503
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0557 0.5117
Loa Loa (eye worm) carbonic anhydrase 3 0.0118 0.1029 0.1453
Loa Loa (eye worm) hypothetical protein 0.0139 0.1257 0.1781
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0064 0.0436 0.0597
Loa Loa (eye worm) hypothetical protein 0.0029 0.005 0.0051
Echinococcus multilocularis lipoxygenase domain containing protein 0.0103 0.0869 0.1204
Schistosoma mansoni nAChR subunit 0.0139 0.1257 0.2119
Brugia malayi Nuclear hormone receptor E75 0.0058 0.037 0.0503
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0088 0.0697 0.0971
Onchocerca volvulus Peroxidase homolog 0.0105 0.0886 0.3873
Loa Loa (eye worm) DR-78 0.0058 0.037 0.051
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0557 0.5117
Loa Loa (eye worm) hypothetical protein 0.0064 0.0436 0.0604
Brugia malayi hypothetical protein 0.0065 0.0447 0.0612
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0058 0.037 0.1568
Brugia malayi latrophilin 2 splice variant baaae 0.008 0.0613 0.0851
Echinococcus granulosus glycine receptor subunit alpha 1 0.0139 0.1257 0.1719
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0064 0.0436 0.0597
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0139 0.1257 0.1774
Echinococcus multilocularis nuclear receptor nhr 48 0.0058 0.037 0.0497
Loa Loa (eye worm) hypothetical protein 0.0027 0.0028 0.002
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0139 0.1257 0.1781
Schistosoma mansoni ankyrin 23/unc44 0.0049 0.0275 0.0437
Echinococcus multilocularis nAChR subunit 0.0139 0.1257 0.1755
Loa Loa (eye worm) hypothetical protein 0.0075 0.0554 0.0773
Trypanosoma cruzi cysteine peptidase, putative 0.0075 0.0557 0.5414
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0075 0.0554 0.0766
Loa Loa (eye worm) steroid hormone receptor 0.0123 0.1084 0.1533
Brugia malayi bZIP transcription factor family protein 0.0288 0.29 0.4129
Loa Loa (eye worm) hypothetical protein 0.0117 0.1021 0.1442
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0027 0.0028 0.0013
Echinococcus granulosus Polycystic kidney disease protein 0.0103 0.0869 0.1179
Loa Loa (eye worm) hypothetical protein 0.0088 0.0697 0.0978
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0088 0.0697 0.116
Loa Loa (eye worm) hypothetical protein 0.0064 0.0436 0.0604
Schistosoma mansoni amidase 0.0098 0.0817 0.1365
Echinococcus granulosus nAChR subunit 0.0075 0.0554 0.0742
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0058 0.037 0.0497
Loa Loa (eye worm) hypothetical protein 0.0278 0.2789 0.3974
Loa Loa (eye worm) hypothetical protein 0.0105 0.0886 0.1249
Loa Loa (eye worm) hypothetical protein 0.0123 0.1084 0.1533
Echinococcus granulosus carbonic anhydrase 0.0027 0.0028 0.0012
Loa Loa (eye worm) hypothetical protein 0.0058 0.037 0.051
Schistosoma mansoni hypothetical protein 0.0103 0.0869 0.1454
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0068 0.0485 0.4718
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0064 0.0436 0.0597
Echinococcus granulosus peroxidasin 0.0105 0.0886 0.1203
Brugia malayi Doublecortin family protein 0.0103 0.0869 0.1217
Loa Loa (eye worm) hypothetical protein 0.0105 0.0886 0.1249
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0075 0.0554 0.0766
Echinococcus granulosus Nuclear hormone receptor HR96 0.0058 0.037 0.0487
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.1099 0.1554
Loa Loa (eye worm) hypothetical protein 0.0105 0.0886 0.1249
Loa Loa (eye worm) hypothetical protein 0.0026 0.0019 0.0008
Schistosoma mansoni nAChR subunit 0.0064 0.0436 0.0713
Loa Loa (eye worm) hypoxia-induced factor 1 0.0177 0.1679 0.2384
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0123 0.1084 0.1526
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0123 0.1084 0.1526
Echinococcus granulosus single minded 2 0.0042 0.0198 0.0248
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0049 0.0275 0.0355
Schistosoma mansoni hypothetical protein 0.0234 0.2307 0.3915
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0139 0.1257 0.1719
Loa Loa (eye worm) hypothetical protein 0.0123 0.1084 0.1533
Brugia malayi Steroid receptor seven-up type 2 0.0123 0.1084 0.1526
Onchocerca volvulus 0.0229 0.2257 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0064 0.0436 0.0597
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0123 0.1084 0.1823
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0064 0.0436 0.0597
Loa Loa (eye worm) hypothetical protein 0.0105 0.0886 0.1249
Loa Loa (eye worm) hypothetical protein 0.0139 0.1257 0.1781
Echinococcus granulosus GPCR family 2 0.0037 0.014 0.0168
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0557 0.5863 0.8284
Schistosoma mansoni rab6-interacting 0.0103 0.0869 0.1454
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0123 0.1084 0.151
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0118 0.1029 0.1728
Loa Loa (eye worm) hypothetical protein 0.0064 0.0436 0.0604
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0058 0.037 0.0487
Brugia malayi nuclear receptor NHR-67 0.0058 0.037 0.0503
Brugia malayi RNA recognition motif domain containing protein 0.014 0.1276 0.1801
Onchocerca volvulus Netrin receptor homolog 0.0049 0.0275 0.1142
Loa Loa (eye worm) hypothetical protein 0.0065 0.0447 0.0619
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0139 0.1257 0.1774
Loa Loa (eye worm) animal heme peroxidase 0.0105 0.0886 0.1249
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0123 0.1084 0.1526
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0118 0.1029 0.1447
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0049 0.0275 0.0362
Loa Loa (eye worm) hypothetical protein 0.0075 0.0554 0.0773
Brugia malayi Uncoordinated protein 44 0.0049 0.0275 0.0366
Loa Loa (eye worm) hypothetical protein 0.0064 0.0436 0.0604
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0139 0.1257 0.1755
Brugia malayi hypothetical protein 0.0064 0.0436 0.0597
Entamoeba histolytica hypothetical protein 0.0036 0.0133 0.2403
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0123 0.1084 0.1533
Echinococcus granulosus fatty acid amide hydrolase 1 0.0098 0.0817 0.1107
Loa Loa (eye worm) hypothetical protein 0.0065 0.0447 0.0619
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0065 0.0447 0.0606
Echinococcus multilocularis serotonin transporter 0.0088 0.0697 0.0961
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.005 0.0043
Entamoeba histolytica hypothetical protein 0.0036 0.0133 0.2403
Brugia malayi nuclear hormone receptor family member nhr-6 0.0058 0.037 0.0503
Loa Loa (eye worm) animal heme peroxidase 0.0105 0.0886 0.1249
Loa Loa (eye worm) hypothetical protein 0.0058 0.037 0.051
Onchocerca volvulus 0.0075 0.0554 0.239
Loa Loa (eye worm) hypothetical protein 0.0123 0.1084 0.1533
Echinococcus granulosus geminin 0.0199 0.1921 0.264
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0139 0.1257 0.1781
Brugia malayi Animal haem peroxidase family protein 0.0105 0.0886 0.1242
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0139 0.1257 0.1755
Echinococcus granulosus carbonic anhydrase 0.0027 0.0028 0.0012
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0139 0.1257 0.1755
Onchocerca volvulus Putative nachr subunit 0.0139 0.1257 0.5534
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0118 0.1029 0.1728
Schistosoma mansoni thyroid hormone receptor 0.0123 0.1084 0.1823
Brugia malayi Pre-SET motif family protein 0.0029 0.005 0.0044
Onchocerca volvulus 0.0139 0.1257 0.5534
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0063 0.043 0.0703
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0139 0.1257 0.2119
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0037 0.014 0.0168
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0557 0.5117
Brugia malayi MH2 domain containing protein 0.0124 0.1099 0.1548
Leishmania major cathepsin L-like protease 0.0075 0.0557 0.5414
Loa Loa (eye worm) hypothetical protein 0.0105 0.0886 0.1249
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0027 0.0028 0.0013
Loa Loa (eye worm) hypothetical protein 0.0058 0.037 0.051
Brugia malayi ecdysone receptor 0.0058 0.037 0.0503
Schistosoma mansoni nAChR subunit 0.0139 0.1257 0.2119
Loa Loa (eye worm) hypothetical protein 0.0123 0.1084 0.1533
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0609 0.6439 0.92
Loa Loa (eye worm) hypothetical protein 0.0064 0.0436 0.0604
Loa Loa (eye worm) ACC-1 protein 0.0139 0.1257 0.1781
Onchocerca volvulus 0.0088 0.0697 0.3029
Loa Loa (eye worm) hypothetical protein 0.0064 0.0436 0.0604
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0123 0.1084 0.1533
Brugia malayi photoreceptor-specific nuclear receptor 0.0123 0.1084 0.1526
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0123 0.1084 0.1823
Onchocerca volvulus Chorion peroxidase homolog 0.0105 0.0886 0.3873
Echinococcus granulosus hypothetical protein 0.068 0.7223 1
Brugia malayi hypothetical protein 0.0103 0.0869 0.1217
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0123 0.1084 0.476
Schistosoma mansoni coup transcription factor 0.0123 0.1084 0.1823
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0123 0.1084 0.1526
Loa Loa (eye worm) hypothetical protein 0.0064 0.0436 0.0604
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0065 0.0447 0.0619
Loa Loa (eye worm) hypothetical protein 0.005 0.0279 0.038
Loa Loa (eye worm) hypothetical protein 0.0058 0.037 0.051
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0064 0.0436 0.0597
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0117 0.1021 0.1442
Brugia malayi Animal haem peroxidase family protein 0.0105 0.0886 0.1242
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0064 0.0436 0.0578
Onchocerca volvulus 0.0139 0.1257 0.5534
Brugia malayi Animal haem peroxidase family protein 0.0105 0.0886 0.1242
Loa Loa (eye worm) hypothetical protein 0.0064 0.0436 0.0604
Echinococcus granulosus netrin receptor unc 5 0.0049 0.0275 0.0355
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0027 0.0028 0.002
Echinococcus multilocularis geminin 0.0199 0.1921 0.2696
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0038 0.0026
Brugia malayi Death domain containing protein 0.0049 0.0275 0.0366
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0133 0.0195
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0058 0.037 0.0601
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0062 1
Loa Loa (eye worm) hypothetical protein 0.0139 0.1257 0.1781
Echinococcus granulosus RUN 0.0103 0.0869 0.1179
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0123 0.1084 0.1479
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0236 0.2329 0.3315
Loa Loa (eye worm) solute carrier family 6 member 4 0.0088 0.0697 0.0978
Brugia malayi nuclear hormone receptor 0.0123 0.1084 0.1526
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0058 0.037 0.0497
Schistosoma mansoni tar DNA-binding protein 0.014 0.1276 0.2151
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0123 0.1084 0.151
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.005 0.0043
Echinococcus multilocularis importin subunit beta 1 0.003 0.0062 0.0061
Schistosoma mansoni hypothetical protein 0.0036 0.0133 0.0195
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0123 0.1084 0.1526
Loa Loa (eye worm) hypothetical protein 0.0435 0.452 0.6452
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.0324 0.0423
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0139 0.1257 0.1781
Trichomonas vaginalis set domain proteins, putative 0.0229 0.2252 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0436 0.0604
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0139 0.1257 0.1719
Echinococcus multilocularis transfer RNA-Lys 0.0042 0.0198 0.0253
Echinococcus multilocularis peroxidasin 0.0105 0.0886 0.1229
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0123 0.1084 0.151
Echinococcus granulosus glycine receptor subunit alpha 1 0.0139 0.1257 0.1719
Loa Loa (eye worm) hypothetical protein 0.0105 0.0886 0.1249
Schistosoma mansoni nuclear hormone receptor 0.0058 0.037 0.0601
Schistosoma mansoni polycystin 1-related 0.0103 0.0869 0.1454
Echinococcus granulosus survival motor neuron protein 1 0.0278 0.2789 0.3846
Loa Loa (eye worm) hypothetical protein 0.0139 0.1257 0.1781
Echinococcus granulosus Ankyrin 0.005 0.0279 0.0361
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0123 0.1084 0.1533
Loa Loa (eye worm) hypothetical protein 0.0065 0.0447 0.0619
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0133 0.0162
Schistosoma mansoni tar DNA-binding protein 0.014 0.1276 0.2151
Brugia malayi nuclear hormone receptor 0.0058 0.037 0.0503
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0064 0.0436 0.0604
Echinococcus multilocularis ecdysone induced protein 78C 0.0123 0.1084 0.151
Echinococcus multilocularis conserved hypothetical protein 0.0667 0.7073 1
Schistosoma mansoni lipoxygenase 0.0371 0.3817 0.6499
Schistosoma mansoni tar DNA-binding protein 0.014 0.1276 0.2151
Schistosoma mansoni nuclear hormone receptor 0.0058 0.037 0.0601
Leishmania major carbonic anhydrase-like protein 0.0118 0.1029 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.0554 0.0773
Echinococcus multilocularis tar DNA binding protein 0.014 0.1276 0.1782
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0123 0.1084 0.1823
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0139 0.1257 0.1774
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0139 0.1257 0.1719
Loa Loa (eye worm) hypothetical protein 0.0058 0.037 0.051
Brugia malayi Nuclear hormone receptor-like 1 0.0123 0.1084 0.1526
Loa Loa (eye worm) hypothetical protein 0.0123 0.1084 0.1533
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0064 0.0436 0.0591
Entamoeba histolytica hypothetical protein 0.0075 0.0554 1
Onchocerca volvulus 0.0103 0.0869 0.3797
Brugia malayi Importin beta-1 subunit 0.003 0.0062 0.0062
Echinococcus granulosus Nuclear hormone receptor HR96 0.0058 0.037 0.0487
Brugia malayi hypothetical protein 0.0192 0.1842 0.2612
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0557 0.5117
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0118 0.1029 0.1453
Echinococcus granulosus nuclear receptor nhr 48 0.0058 0.037 0.0487
Schistosoma mansoni hypothetical protein 0.0037 0.014 0.0207
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0064 0.0436 0.0591
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0064 0.0436 0.0604
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0063 0.043 0.0583
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0027 0.0028 0.0013
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0075 0.0554 0.0915
Loa Loa (eye worm) hypothetical protein 0.066 0.6998 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0118 0.1029 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.037 0.051
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0123 0.1084 0.1479
Trypanosoma cruzi cysteine peptidase, putative 0.0075 0.0557 0.5414
Brugia malayi steroid hormone receptor 0.0123 0.1084 0.1526
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0063 0.043 0.0571
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0123 0.1084 0.1526
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0063 0.043 0.4181
Echinococcus granulosus glycine receptor subunit beta 0.0139 0.1257 0.1719
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0557 0.5117
Schistosoma mansoni nuclear receptor 0.0058 0.037 0.0601
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0058 0.037 0.051
Brugia malayi hypothetical protein 0.0058 0.037 0.0503
Echinococcus multilocularis Polycystic kidney disease protein 0.0103 0.0869 0.1204
Brugia malayi hypothetical protein 0.0064 0.0436 0.0597
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0123 0.1084 0.1526
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0139 0.1257 0.1755
Loa Loa (eye worm) hypothetical protein 0.0123 0.1084 0.1533
Brugia malayi nuclear receptor NHR-88 0.0058 0.037 0.0503
Loa Loa (eye worm) hypothetical protein 0.0139 0.1257 0.1781
Loa Loa (eye worm) animal heme peroxidase 0.0105 0.0886 0.1249
Loa Loa (eye worm) hypothetical protein 0.0075 0.0554 0.0773
Schistosoma mansoni sodium/chloride dependent transporter 0.0088 0.0697 0.116
Brugia malayi small heat shock protein 0.066 0.6998 1
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0019 0.0008
Echinococcus multilocularis RUN 0.0103 0.0869 0.1204
Onchocerca volvulus Bile acid receptor homolog 0.0123 0.1084 0.476
Schistosoma mansoni retinoic acid receptor RXR 0.0239 0.2359 0.4004
Onchocerca volvulus Peroxidase homolog 0.0105 0.0886 0.3873
Echinococcus multilocularis thyroid hormone receptor alpha 0.0123 0.1084 0.151
Brugia malayi bHLH-PAS transcription factor 0.0042 0.0198 0.0256
Brugia malayi Protein kinase domain containing protein 0.0049 0.0275 0.0366
Echinococcus granulosus glycine receptor subunit beta 0.0139 0.1257 0.1719
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0075 0.0554 0.0766
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.0324 0.0423
Loa Loa (eye worm) hypothetical protein 0.0609 0.6439 0.92
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0133 0.0158
Onchocerca volvulus 0.0139 0.1257 0.5534
Loa Loa (eye worm) hypothetical protein 0.0105 0.0886 0.1249
Echinococcus multilocularis glycine receptor subunit beta 0.0139 0.1257 0.1755
Onchocerca volvulus 0.0139 0.1257 0.5534
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0557 0.5863 0.8112
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0064 0.0436 0.0591
Echinococcus multilocularis carbonic anhydrase 0.0027 0.0028 0.0012
Schistosoma mansoni hypothetical protein 0.0037 0.014 0.0207
Brugia malayi hypothetical protein 0.0105 0.0886 0.1242
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0139 0.1257 0.1774
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0098 0.0817 0.1131
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0058 0.037 0.0487
Schistosoma mansoni zinc finger protein 0.0058 0.037 0.0601
Brugia malayi Immunoglobulin I-set domain containing protein 0.0049 0.0275 0.0366
Loa Loa (eye worm) hypothetical protein 0.0075 0.0554 0.0773
Brugia malayi excitatory GABA receptor EXP-1A 0.0139 0.1257 0.1774
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0118 0.1029 1
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0139 0.1257 0.1774
Schistosoma mansoni loxhd1 0.0103 0.0869 0.1454
Echinococcus granulosus serotonin transporter 0.0088 0.0697 0.0941
Schistosoma mansoni peroxidasin 0.0105 0.0886 0.1483
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0139 0.1257 0.1774
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0139 0.1257 0.1781
Loa Loa (eye worm) hypothetical protein 0.0058 0.037 0.051
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0139 0.1257 0.2119
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0123 0.1084 0.1533
Loa Loa (eye worm) hypothetical protein 0.0064 0.0436 0.0604
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.005 0.0043
Brugia malayi hypothetical protein 0.0226 0.222 0.3154
Loa Loa (eye worm) hypothetical protein 0.0139 0.1257 0.1781
Loa Loa (eye worm) blistered cuticle protein 3 0.0105 0.0886 0.1249
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0065 0.0447 0.0731
Loa Loa (eye worm) hypothetical protein 0.0105 0.0886 0.1249
Loa Loa (eye worm) hypothetical protein 0.0064 0.0436 0.0604
Loa Loa (eye worm) hypothetical protein 0.0139 0.1257 0.1781
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0557 0.5117
Loa Loa (eye worm) hypothetical protein 0.003 0.0062 0.007
Loa Loa (eye worm) hypothetical protein 0.0027 0.0028 0.002
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0123 0.1084 0.151
Brugia malayi nuclear hormone receptor family member odr-7 0.0058 0.037 0.0503
Schistosoma mansoni rab6-interacting 0.0103 0.0869 0.1454
Schistosoma mansoni hypothetical protein 0.0199 0.1921 0.3255
Brugia malayi hypoxia-induced factor 1 0.0177 0.1679 0.2378
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0139 0.1257 0.2119
Loa Loa (eye worm) nuclear hormone receptor 0.0058 0.037 0.051
Brugia malayi Animal haem peroxidase family protein 0.0105 0.0886 0.1242
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0139 0.1257 0.1755
Schistosoma mansoni acetylcholine receptor-related 0.0064 0.0436 0.0713
Onchocerca volvulus 0.0139 0.1257 0.5534
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0123 0.1084 0.1823
Brugia malayi hypothetical protein 0.0036 0.0133 0.0163
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0027 0.0028 0.0013
Loa Loa (eye worm) hypothetical protein 0.0075 0.0554 0.0773
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.005 0.0053
Loa Loa (eye worm) hypothetical protein 0.0105 0.0886 0.1249
Schistosoma mansoni nAChR subunit 0.0139 0.1257 0.2119
Loa Loa (eye worm) hypothetical protein 0.0058 0.037 0.051
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0174 0.1645 0.2304
Loa Loa (eye worm) hypothetical protein 0.0027 0.0028 0.002
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0139 0.1257 0.1755
Onchocerca volvulus 0.0064 0.0436 0.1862
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0288 0.29 0.4084
Schistosoma mansoni hypothetical protein 0.008 0.0613 0.1016
Loa Loa (eye worm) cytochrome P450 family protein 0.0107 0.0913 0.1288
Leishmania major cathepsin L-like protease 0.0075 0.0557 0.5414
Loa Loa (eye worm) hypothetical protein 0.0105 0.0886 0.1249
Echinococcus multilocularis jun protein 0.0288 0.29 0.4084
Onchocerca volvulus 0.0058 0.037 0.1568
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0139 0.1257 0.1781
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0139 0.1257 0.1755
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0037 0.014 0.0171

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 67 nM Inhibition of [125I]-eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells ChEMBL. 15771462
IC50 (binding) = 67 nM Inhibition of [125I]-eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells ChEMBL. 15771462
IC50 (binding) = 423 nM Inhibition of [125I]-eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells ChEMBL. 15771462
IC50 (binding) = 423 nM Inhibition of [125I]-eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells ChEMBL. 15771462
Ki (binding) 0 nM Inhibitory constant for 5-hydroxytryptamine 2A receptor (NT= Not tested) ChEMBL. 15771462
Ki (binding) 0 nM Inhibitory constant for 5-hydroxytryptamine 2C receptor (NT= Not tested) ChEMBL. 15771462
Ki (binding) 0 nM Inhibitory constant for Dopamine receptor D2 (NT= Not tested) ChEMBL. 15771462

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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