Detailed information for compound 325249

Basic information

Technical information
  • TDR Targets ID: 325249
  • Name: 2-azaniumyl-5-(carbamoylamino)pentanoate
  • MW: 175.186 | Formula: C6H13N3O3
  • H donors: 4 H acceptors: 3 LogP: -3.91 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=O)NCCCC(C(=O)O)N
  • InChi: 1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)
  • InChiKey: RHGKLRLOHDJJDR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-azaniumyl-5-ureido-pentanoate
  • 2-ammonio-5-ureidopentanoate
  • 5-(aminocarbonylamino)-2-azaniumyl-pentanoate
  • 2-ammonio-5-ureido-valerate
  • 2-amino-5-(carbamoylamino)pentanoic acid
  • 2-amino-5-ureido-pentanoic acid
  • 2-amino-5-ureidopentanoic acid
  • 5-(aminocarbonylamino)-2-azanyl-pentanoic acid
  • 2-amino-5-ureido-valeric acid
  • Citrulline
  • 2-amino-5-(aminocarbonylamino)pentanoic acid
  • 627-77-0
  • 372-75-8
  • 13594-51-9
  • N(5)-carbamoyl-DL-ornithine
  • N(5)-carbamoylornithine
  • citrulina
  • KBioSS_000397
  • DivK1c_006619
  • BSPBio_002570
  • SDCCGMLS-0066976.P001
  • EINECS 211-012-2
  • to_000034
  • DL-Citrulline
  • NSC46711
  • Spectrum5_001792
  • L-Ornithine, N(5)-(aminocarbonyl)-
  • KBio3_001790
  • Ornithine, N5-carbamoyl-, L-
  • KBio2_002965
  • KBio2_005533
  • SPBio_001322
  • Spectrum4_001185
  • KBioGR_001849
  • KBio2_000397
  • SpecPlus_000523
  • SGCUT00061
  • Sitrulline
  • Spectrum2_001371
  • Spectrum3_001045
  • DL-Ornithine, N(5)-(aminocarbonyl)-
  • NSC206276
  • KBio1_001563
  • .alpha.-Amino-.delta.-ureidovaleric acid
  • .delta.-Ureidonorvaline
  • CITRULLINE,(L)
  • L-Cytrulline
  • L-Ornithine, N5-(aminocarbonyl)-
  • N(.delta.)-Carbamylornithine
  • N.delta.-Carbamylornithine
  • N5-Carbamoyl-L-ornithine
  • NSC27425
  • L-CITRULLINE
  • N5-(Aminocarbonyl)-L-ornithine
  • Ngamma-carbamylornithine
  • alpha-amino-gamma-ureidovaleric acid
  • gammaureidonorvaline
  • Spectrum_000037
  • 2-Amino-5-uredovaleric acid
  • CHEBI:18211
  • Citrullin
  • DL-2-amino-5-ureidovaleric acid
  • N(5)-(aminocarbonyl)-DL-ornithine
  • N(5)-(aminocarbonyl)ornithine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0041 0.032 0.1214
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0047 0.015
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0279 1
Echinococcus multilocularis protoporphyrinogen oxidase 0.0021 0.0102 0.0082
Schistosoma mansoni hypothetical protein 0.0015 0.0042 0.0087
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0041 0.032 0.5068
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0021 0.0102 0.1379
Schistosoma mansoni sodium/chloride dependent transporter 0.0239 0.2488 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0047 0.0086
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0191 0.0614
Onchocerca volvulus Alhambra homolog 0.0029 0.0191 0.0371
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0191 0.2065
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0132 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0279 0.0898
Loa Loa (eye worm) hypothetical protein 0.0023 0.0132 0.0425
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0061 0.004
Loa Loa (eye worm) hypothetical protein 0.0017 0.0068 0.0218
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0329
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0628 0.2018
Loa Loa (eye worm) hypothetical protein 0.0041 0.032 0.1028
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0021 0.0102 0.1379
Schistosoma mansoni hypothetical protein 0.0016 0.0047 0.0108
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0061 0.0163
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0531 0.1538
Loa Loa (eye worm) hypothetical protein 0.0034 0.0244 0.0785
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0314 0.0295
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0531 0.2072
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0041 0.032 0.03
Schistosoma mansoni ap endonuclease 0.0037 0.0279 0.1051
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0278 0.0833
Brugia malayi Bromodomain containing protein 0.0038 0.029 0.0931
Brugia malayi PHD-finger family protein 0.0029 0.0191 0.0614
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0617 0.242
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0041 0.032 0.1028
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0617 0.242
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0191 0.2065
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0279 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0047 0.015
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0293 0.3083 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0191 0.0553
Toxoplasma gondii hypothetical protein 0.0041 0.032 0.5068
Echinococcus multilocularis chromobox protein 1 0.0069 0.0628 0.0609
Loa Loa (eye worm) hypothetical protein 0.0041 0.032 0.1028
Loa Loa (eye worm) serotonin transporter b 0.0239 0.2488 0.7996
Echinococcus multilocularis chromobox protein 1 0.0069 0.0628 0.0609
Loa Loa (eye worm) hypothetical protein 0.003 0.0207 0.0665
Echinococcus multilocularis sodium and chloride dependent glycine 0.0041 0.032 0.03
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0067 0.0216
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0061 0.013
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0244 0.0785
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0273 0.2857 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0068 0.0037
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0906 0.2867
Schistosoma mansoni hypothetical protein 0.0016 0.0047 0.0108
Loa Loa (eye worm) hypothetical protein 0.0296 0.3111 1
Schistosoma mansoni ap endonuclease 0.0037 0.0279 0.1051
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0279 0.2309
Loa Loa (eye worm) hypothetical protein 0.0039 0.0298 0.0957
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0531 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0279 0.8397
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.012 0.01
Plasmodium vivax amine transporter, putative 0.0041 0.032 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0041 0.032 0.1214
Trypanosoma cruzi UDP-galactopyranose mutase 0.0021 0.0102 0.2558
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0264 0.0789
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0628 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0132 0.0286
Loa Loa (eye worm) norepinephrine transporter 0.0239 0.2488 0.7996
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0021 0.0102 0.0082
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0047 0.0086
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0617 0.242
Plasmodium falciparum protoporphyrinogen oxidase 0.0021 0.0102 0.1379
Onchocerca volvulus 0.0041 0.032 0.0912
Schistosoma mansoni chromobox protein 0.0069 0.0628 0.2463
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0279 0.0794
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0531 0.1538
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0047 0.0027
Echinococcus granulosus peregrin 0.0031 0.0217 0.0635
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0041 0.032 0.1214
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0279 1
Plasmodium vivax hypothetical protein, conserved 0.0041 0.032 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0191 0.0614
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0021 0.0102 0.1379
Onchocerca volvulus 0.0041 0.032 0.0912
Mycobacterium ulcerans dehydrogenase 0.0021 0.0102 0.0115
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0021 0.0102 0.0115
Brugia malayi RNA binding protein 0.0068 0.0617 0.1985
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0329
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0368 0.1183
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0041 0.032 0.1028
Echinococcus multilocularis muscleblind protein 0.0296 0.3111 0.3097
Echinococcus granulosus chromobox protein 1 0.0069 0.0628 0.1966
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0531 0.1654
Brugia malayi PHD-finger family protein 0.0025 0.0145 0.0467
Loa Loa (eye worm) hypothetical protein 0.0017 0.0068 0.0218
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0041 0.032 0.0969
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0041 0.032 0.1214
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0368 0.1125
Brugia malayi Muscleblind-like protein 0.0296 0.3111 1
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0041 0.032 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.032 0.1028
Echinococcus granulosus zinc finger protein 0.0019 0.0088 0.0219
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0041 0.032 0.1028
Onchocerca volvulus 0.0023 0.0132 0.0125
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0414 0.1331
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0047 0.015
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0298 0.2714
Schistosoma mansoni bromodomain containing protein 0.0062 0.0559 0.2184
Echinococcus multilocularis serotonin transporter 0.0239 0.2488 0.2472
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0102 0.1379
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0041 0.032 0.1028
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0279 1
Schistosoma mansoni hypothetical protein 0.0194 0.1992 0.7992
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0329
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0906 0.0888
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0526 0.169
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0191 0.0692
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0041 0.032 0.03
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0041 0.032 0.1214
Echinococcus multilocularis geminin 0.0194 0.1992 0.1976
Loa Loa (eye worm) hypothetical protein 0.0239 0.2488 0.7996
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0368 0.141
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0132 0.0214
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0041 0.032 0.1214
Loa Loa (eye worm) solute carrier family 6 member 4 0.0239 0.2488 0.7996
Brugia malayi jmjC domain containing protein 0.0094 0.0906 0.2913
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0132 0.0425
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0628 1
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0041 0.032 0.03
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0617 0.1985
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0278 0.1044
Plasmodium falciparum transporter, putative 0.0041 0.032 1
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0099 0.0319
Loa Loa (eye worm) hypothetical protein 0.0041 0.032 0.1028
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0368 0.0349
Brugia malayi Bromodomain containing protein 0.0031 0.0217 0.0696
Schistosoma mansoni amine oxidase 0.0021 0.0102 0.0333
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0041 0.032 0.1028
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0279 0.8397
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0279 0.0702
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.0195
Echinococcus granulosus lysine specific histone demethylase 1A 0.0021 0.0102 0.0266
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0368 0.1183
Treponema pallidum sodium- and chloride- dependent transporter 0.0239 0.2488 1
Schistosoma mansoni sodium-dependent amino acid transporter 0.0041 0.032 0.1214
Echinococcus multilocularis 0.0021 0.0102 0.0082
Schistosoma mansoni hypothetical protein 0.0194 0.1992 0.7992
Echinococcus granulosus sodium and chloride dependent glycine 0.0041 0.032 0.0969
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0132 0.0214
Echinococcus multilocularis zinc finger protein 0.0019 0.0088 0.0068
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0264 0.0244
Echinococcus multilocularis GPCR, family 2 0.0016 0.0047 0.0027
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0279 0.0839
Loa Loa (eye worm) hypothetical protein 0.0049 0.0414 0.1331
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0298 0.0819
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0132 0.0286
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0191 0.0171
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0531 0.1538
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0329
Brugia malayi Heterochromatin protein 1 0.0069 0.0628 0.2018
Mycobacterium tuberculosis Possible oxidoreductase 0.0021 0.0102 0.0161
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0041 0.032 0.0969
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0617 0.242
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0132 0.0214
Trichomonas vaginalis chromobox protein, putative 0.0041 0.033 0.3419
Onchocerca volvulus 0.003 0.0207 0.0438
Echinococcus granulosus muscleblind protein 0.0296 0.3111 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0061 0.0163
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0279 0.5
Schistosoma mansoni hypothetical protein 0.0029 0.0191 0.0692
Loa Loa (eye worm) hypothetical protein 0.0017 0.0068 0.0218
Echinococcus granulosus sodium and chloride dependent glycine 0.0041 0.032 0.0969
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0279 0.0898
Loa Loa (eye worm) hypothetical protein 0.0049 0.0416 0.1336
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0293 0.3083 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0279 0.075
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0021 0.0102 0.0333
Brugia malayi amine oxidase, flavin-containing family protein 0.0021 0.0102 0.0329
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0531 0.0512
Brugia malayi hypothetical protein 0.0041 0.032 0.1028
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0041 0.032 0.1214
Trypanosoma cruzi UDP-galactopyranose mutase 0.0021 0.0102 0.2558
Echinococcus multilocularis peregrin 0.0031 0.0217 0.0197
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0047 0.0027
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0041 0.032 0.0969
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.002 0.0065
Loa Loa (eye worm) hypothetical protein 0.0042 0.0337 0.1082
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0368 0.1125
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0617 0.1985
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0041 0.032 0.1028
Schistosoma mansoni amine oxidase 0.0021 0.0102 0.0333
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0102 0.1379
Onchocerca volvulus 0.0055 0.0483 0.1596
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0414 0.1331
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0368 0.141
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0329
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0239 0.2488 1
Echinococcus multilocularis sodium and chloride dependent glycine 0.0041 0.032 0.03
Plasmodium falciparum amino acid transporter, putative 0.0041 0.032 1
Leishmania major UDP-galactopyranose mutase 0.0021 0.0102 0.0192
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0191 0.4891
Loa Loa (eye worm) hypothetical protein 0.004 0.0316 0.1016
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0132 0.0425
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0329
Loa Loa (eye worm) hypothetical protein 0.0296 0.3111 1
Loa Loa (eye worm) hypothetical protein 0.0239 0.2488 0.7996
Loa Loa (eye worm) hypothetical protein 0.0017 0.0068 0.0218
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0531 0.2072
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0132 0.0425
Schistosoma mansoni sodium/chloride dependent transporter 0.0041 0.032 0.1214
Loa Loa (eye worm) hypothetical protein 0.0041 0.032 0.1028
Schistosoma mansoni hypothetical protein 0.0016 0.0047 0.0108
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0617 0.1985
Echinococcus granulosus serotonin transporter 0.0239 0.2488 0.7983
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0132 0.0214
Echinococcus multilocularis muscleblind protein 1 0.0296 0.3111 0.3097
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0279 0.2309
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0617 0.242
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0041 0.032 0.0969
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0298 0.2714
Echinococcus granulosus lysine specific histone demethylase 1A 0.0021 0.0102 0.0266
Echinococcus granulosus geminin 0.0194 0.1992 0.638
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0368 0.141
Loa Loa (eye worm) hypothetical protein 0.0017 0.0068 0.0218
Schistosoma mansoni zinc finger protein 0.0015 0.0042 0.0087
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0279 0.026
Mycobacterium ulcerans hypothetical protein 0.0023 0.0132 0.0214
Loa Loa (eye worm) hypothetical protein 0.0023 0.0132 0.0425
Onchocerca volvulus 0.0041 0.032 0.0912
Chlamydia trachomatis protoporphyrinogen oxidase 0.0021 0.0102 0.1379
Schistosoma mansoni chromobox protein 0.0069 0.0628 0.2463
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0041 0.032 0.5068
Brugia malayi jmjC domain containing protein 0.0037 0.0278 0.0893
Echinococcus granulosus tar DNA binding protein 0.0068 0.0617 0.1932
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0041 0.032 0.1214
Mycobacterium ulcerans oxidoreductase 0.0021 0.0102 0.0115
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0278 0.0893
Loa Loa (eye worm) hypothetical protein 0.0041 0.032 0.1028
Loa Loa (eye worm) hypothetical protein 0.0023 0.0132 0.0425
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.052 0.1618
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.012 0.0322
Loa Loa (eye worm) hypothetical protein 0.0041 0.032 0.1028
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.012 0.0403
Trichomonas vaginalis chromobox protein, putative 0.0041 0.033 0.3419
Loa Loa (eye worm) hypothetical protein 0.0239 0.2488 0.7996
Schistosoma mansoni hypothetical protein 0.002 0.0099 0.032
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.033 0.0953
Schistosoma mansoni hypothetical protein 0.0034 0.0244 0.0908
Toxoplasma gondii exonuclease III APE 0.0037 0.0279 0.4126
Echinococcus granulosus chromobox protein 1 0.0069 0.0628 0.1966
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0132 1
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0695 0.2734
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.015
Schistosoma mansoni zinc finger protein 0.0019 0.0088 0.0274
Echinococcus granulosus jumonji domain containing protein 0.004 0.0314 0.0951
Brugia malayi SWIRM domain containing protein 0.0021 0.0102 0.0329
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0531 0.1693
Loa Loa (eye worm) RNA binding protein 0.0068 0.0617 0.1985
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0132 0.0214
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0132 0.0268
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0239 0.2488 0.7996
Schistosoma mansoni sodium/chloride dependent transporter 0.0041 0.032 0.1214
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0061 0.0163
Plasmodium falciparum phd finger protein, putative 0.0029 0.0191 0.4891
Schistosoma mansoni hypothetical protein 0.0016 0.0047 0.0108
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0061 0.004
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0061 0.013
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0279 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0132 0.0214
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0132 0.0214
Onchocerca volvulus 0.0239 0.2488 1
Leishmania major cysteine desulfhydrase 0.0305 0.3212 1
Echinococcus granulosus GPCR family 2 0.0016 0.0047 0.0086
Brugia malayi Bromodomain containing protein 0.0074 0.0685 0.2203
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0021 0.0102 0.1379
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0102 0.0161
Mycobacterium ulcerans monoamine oxidase 0.0021 0.0102 0.0115
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0132 0.0268
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.052 0.0501
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0414 0.1331
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0041 0.032 0.5068
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0257 0.0237
Loa Loa (eye worm) hypothetical protein 0.0038 0.029 0.0933
Loa Loa (eye worm) hypothetical protein 0.007 0.0639 0.2055
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0061 0.0163
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0021 0.0102 0.0333
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0531 0.1545
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0132 0.0286
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0617 0.0598
Toxoplasma gondii hypothetical protein 0.0041 0.032 0.5068
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0368 0.0349
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0278 0.1044
Brugia malayi CHD4 protein 0.0013 0.002 0.0065
Brugia malayi chromobox protein homolog 3 0.0039 0.0298 0.0957
Brugia malayi TAR-binding protein 0.0068 0.0617 0.1985
Brugia malayi hypothetical protein 0.0021 0.0102 0.0329

Activities

Activity type Activity value Assay description Source Reference
Kd = 68 uM Dissociation constant of the compound ChEMBL. 15293991

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

26 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.