TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 220.307 | Formula: C14H20O2
H donors: 1 H acceptors: 2 LogP: 4.09 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCC(Cc1cccc(c1)C(C(=O)O)C)C
InChi: 1S/C14H20O2/c1-4-10(2)8-12-6-5-7-13(9-12)11(3)14(15)16/h5-7,9-11H,4,8H2,1-3H3,(H,15,16)
InChiKey: MKEVMCJZLHDVPO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	STE family protein kinase	0.0041	0.0011	0.0273
Trypanosoma brucei	epsilon tubulin	0.0065	0.0131	0.1864
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0055	0.0079	0.0713
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0144	0.0525	0.5042
Trypanosoma brucei	epsilon tubulin	0.0065	0.0131	0.1864
Toxoplasma gondii	chorismate synthase, putative	0.0744	0.3514	1
Toxoplasma gondii	alpha-tubulin I, putative	0.0121	0.041	0.0828
Schistosoma mansoni	tubulin subunit beta	0.0065	0.0131	0.1181
Echinococcus multilocularis		0.0144	0.0525	0.5411
Entamoeba histolytica	tubulin gamma chain	0.0065	0.0131	0.3017
Leishmania major	beta tubulin	0.0065	0.0131	0.0041
Leishmania major	beta tubulin	0.0065	0.0131	0.0041
Chlamydia trachomatis	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0.0198	0.0795	0.1165
Trypanosoma brucei	tubulin gamma chain	0.0065	0.0131	0.1864
Toxoplasma gondii	shikimate dehydrogenase substrate binding domain-containing protein	0.0325	0.1425	0.3828
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0144	0.0525	1
Plasmodium vivax	hypothetical protein, conserved	0.0144	0.0525	0.1167
Trichomonas vaginalis	tubulin beta chain, putative	0.0121	0.041	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0068	0.0344
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0269	0.1369
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0121	0.041	1
Schistosoma mansoni	alpha tubulin	0.0121	0.041	0.3914
Trichomonas vaginalis	tubulin beta chain, putative	0.0121	0.041	1
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.1901	0.9282	1
Echinococcus granulosus	tubulin subunit TubB	0.0121	0.041	0.4201
Loa Loa (eye worm)	alpha-tubulin	0.0121	0.041	0.2086
Leishmania major	alpha tubulin	0.0121	0.041	0.7091
Trypanosoma cruzi	alpha tubulin, putative	0.0121	0.041	0.7487
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0226	0.1151
Echinococcus granulosus	tubulin subunit beta	0.0065	0.0131	0.1267
Schistosoma mansoni	vam6/vps39 related	0.0052	0.0068	0.0554
Echinococcus granulosus	tubulin beta 1 chain	0.0065	0.0131	0.1267
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0093	0.0269	0.1369
Echinococcus granulosus	tubulin alpha 1C chain	0.0121	0.041	0.4201
Leishmania major	beta tubulin	0.0065	0.0131	0.0041
Schistosoma mansoni	alpha tubulin	0.0121	0.041	0.3914
Chlamydia trachomatis	phosphoshikimate 1-carboxyl vinyltransferase	0.0325	0.1425	0.3212
Schistosoma mansoni	hypothetical protein	0.0052	0.0068	0.0554
Leishmania major	beta tubulin	0.0065	0.0131	0.0041
Leishmania major	alpha tubulin	0.0121	0.041	0.7091
Leishmania major	alpha tubulin	0.0121	0.041	0.7091
Echinococcus granulosus	GTPase activating Rap:RanGAP domain 3	0.0052	0.0068	0.0595
Plasmodium falciparum	alpha tubulin 2	0.0121	0.041	0.0828
Brugia malayi	Protein kinase domain containing protein	0.0433	0.1965	1
Leishmania major	beta tubulin	0.0065	0.0131	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0144	0.0525	0.267
Loa Loa (eye worm)	hypothetical protein	0.0115	0.0378	0.1924
Brugia malayi	amine oxidase, flavin-containing family protein	0.0144	0.0525	0.2628
Echinococcus multilocularis	Tubulin beta 2C chain	0.0065	0.0131	0.1267
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0144	0.0525	0.5411
Trypanosoma brucei	beta tubulin	0.0065	0.0131	0.1864
Schistosoma mansoni	amine oxidase	0.0144	0.0525	0.5042
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0121	0.041	0.4201
Entamoeba histolytica	tubulin alpha-1 chain	0.0121	0.041	1
Loa Loa (eye worm)	BEN-1 protein	0.0065	0.0131	0.0669
Brugia malayi	Protein kinase domain containing protein	0.0065	0.0129	0.0601
Echinococcus granulosus	Tubulin beta 2C chain	0.0065	0.0131	0.1267
Echinococcus multilocularis	tubulin gamma 1 chain	0.0065	0.0131	0.1267
Toxoplasma gondii	alpha tubulin TUBA1	0.0121	0.041	0.0828
Chlamydia trachomatis	chorismate synthase	0.0744	0.3514	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0121	0.041	1
Leishmania major	beta tubulin	0.0065	0.0131	0.0041
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0144	0.0525	0.0734
Loa Loa (eye worm)	hypothetical protein	0.0144	0.0525	0.267
Schistosoma mansoni	tubulin subunit beta	0.0065	0.0131	0.1181
Loa Loa (eye worm)	tubulin beta-2A chain	0.0065	0.0131	0.0669
Brugia malayi	tubulin alpha-2 chain	0.0121	0.041	0.2041
Leishmania major	beta tubulin	0.0065	0.0131	0.0041
Echinococcus granulosus	Tubulin beta 2C chain	0.0065	0.0131	0.1267
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.017	0.0652	0.6756
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0144	0.0525	0.1167
Plasmodium vivax	hypothetical protein, conserved	0.0144	0.0525	0.1167
Brugia malayi	Protein kinase domain containing protein	0.017	0.0652	0.3282
Echinococcus granulosus	tubulin alpha 3 chain	0.0121	0.041	0.4201
Echinococcus granulosus	Tubulin beta 2C chain	0.0065	0.0131	0.1267
Echinococcus granulosus	serine:threonine protein kinase mig 15	0.0115	0.0378	0.3866
Echinococcus granulosus	tubulin beta 4A class IVa	0.0065	0.0131	0.1267
Plasmodium vivax	tubulin gamma chain, putative	0.0065	0.0131	0.0005
Trichomonas vaginalis	tubulin beta chain, putative	0.0121	0.041	1
Loa Loa (eye worm)	CMGC/CLK protein kinase	0.0065	0.013	0.0661
Leishmania major	beta tubulin	0.0065	0.0131	0.0041
Schistosoma mansoni	serine/threonine protein kinase	0.0055	0.0079	0.0664
Loa Loa (eye worm)	STE/STE20/KHS protein kinase	0.017	0.0652	0.332
Loa Loa (eye worm)	camk/mapkapk/mnk protein kinase	0.0433	0.1965	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0121	0.041	1
Echinococcus multilocularis	casein kinase I gamma	0.0065	0.0129	0.1237
Echinococcus multilocularis	tubulin subunit beta	0.0065	0.0131	0.1267
Treponema pallidum	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0.0198	0.0795	0.5
Plasmodium falciparum	protoporphyrinogen oxidase	0.0144	0.0525	0.1167
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0144	0.0525	0.1167
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0065	0.0131	0.3207
Echinococcus multilocularis	tubulin alpha 3 chain	0.0121	0.041	0.4201
Trichomonas vaginalis	tubulin alpha chain, putative	0.0065	0.0131	0.3207
Mycobacterium ulcerans	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0.0198	0.0795	0.0375
Echinococcus multilocularis	peroxisome assembly protein 26	0.0121	0.041	0.4201
Leishmania major	alpha tubulin	0.0121	0.041	0.7091
Loa Loa (eye worm)	hypothetical protein	0.0144	0.0525	0.267
Mycobacterium leprae	probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS	0.0325	0.1425	0.8249
Leishmania major	epsilon tubulin, putative	0.0065	0.0131	0.0041
Plasmodium vivax	chorismate synthase	0.0744	0.3514	1
Giardia lamblia	Kinase, CMGC CLK	0.0065	0.013	0.2976
Trypanosoma brucei	beta tubulin	0.0065	0.0131	0.1864
Mycobacterium leprae	Chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase).	0.0367	0.1635	1
Entamoeba histolytica	tubulin family protein	0.0065	0.0131	0.3017
Trypanosoma brucei	alpha tubulin	0.0121	0.041	1
Schistosoma mansoni	tubulin subunit alpha	0.0121	0.041	0.3914
Entamoeba histolytica	tubulin alpha chain, putative	0.0121	0.041	1
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0084	0.0226	0.1151
Echinococcus multilocularis	GTPase activating Rap:RanGAP domain 3	0.0052	0.0068	0.0595
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0065	0.0131	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0144	0.0525	0.267
Trichomonas vaginalis	tubulin alpha chain, putative	0.0065	0.0131	0.3207
Plasmodium vivax	tubulin beta chain, putative	0.0065	0.0131	0.0005
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0144	0.0525	0.5042
Toxoplasma gondii	beta tubulin	0.0065	0.0131	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0297	0.1513
Trichomonas vaginalis	tubulin, putative	0.0065	0.0131	0.3207
Onchocerca volvulus		0.0144	0.0525	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0065	0.0131	0.1267
Echinococcus granulosus	Vam6:Vps39 protein	0.0052	0.0068	0.0595
Trypanosoma brucei	beta tubulin	0.0065	0.0131	0.1864
Plasmodium vivax	tubulin epsilon chain, putative	0.0065	0.0131	0.0005
Toxoplasma gondii	beta-1 tubulin, putative	0.0065	0.0131	0.0005
Schistosoma mansoni	tubulin subunit alpha	0.0121	0.041	0.3914
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.017	0.0652	0.6756
Entamoeba histolytica	tubulin family protein	0.0065	0.0131	0.3017
Trichomonas vaginalis	tubulin gamma chain, putative	0.0065	0.0131	0.3207
Leishmania major	beta tubulin	0.0065	0.0131	0.0041
Schistosoma mansoni	mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3	0.0052	0.0068	0.0554
Echinococcus multilocularis	cdgsh iron sulfur domain containing protein	0.0231	0.096	1
Echinococcus multilocularis	tubulin alpha chain	0.0121	0.041	0.4201
Plasmodium falciparum	alpha tubulin 1	0.0121	0.041	0.0828
Trypanosoma brucei	kinetoplastid kinetochore protein 19	0.0065	0.013	0.1817
Trypanosoma cruzi	tubulin gamma chain	0.0065	0.0131	0.1396
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0144	0.0525	0.0286
Trypanosoma cruzi	epsilon tubulin, putative	0.0065	0.0131	0.1396
Loa Loa (eye worm)	casein kinase	0.0062	0.0117	0.0597
Loa Loa (eye worm)	tubulin gamma chain	0.0065	0.0131	0.0669
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.0065	0.013	0.136
Schistosoma mansoni	hypothetical protein	0.0245	0.103	1
Echinococcus granulosus	tubulin alpha chain	0.0121	0.041	0.4201
Wolbachia endosymbiont of Brugia malayi	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0.0198	0.0795	0.5
Giardia lamblia	Alpha-tubulin	0.0121	0.041	1
Echinococcus granulosus	alpha tubulin	0.0121	0.041	0.4201
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0119	0.0604
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0144	0.0525	0.5411
Giardia lamblia	Beta tubulin	0.0065	0.0131	0.3017
Loa Loa (eye worm)	tubulin beta chain	0.0065	0.0131	0.0669
Trypanosoma cruzi	beta tubulin, putative	0.0065	0.0131	0.1396
Echinococcus multilocularis	dual specificity protein kinase clk2	0.0065	0.013	0.125
Echinococcus multilocularis	Tubulin beta 2C chain	0.0065	0.0131	0.1267
Mycobacterium ulcerans	3-phosphoshikimate 1-carboxyvinyltransferase	0.0325	0.1425	0.1033
Echinococcus multilocularis	tubulin alpha chain	0.0121	0.041	0.4201
Echinococcus granulosus	Tubulin alpha 1 chain	0.0121	0.041	0.4201
Leishmania major	alpha tubulin	0.0121	0.041	0.7091
Brugia malayi	Tubulin alpha-2 chain	0.0121	0.041	0.2041
Echinococcus multilocularis	hypothetical protein	0.0121	0.041	0.4201
Echinococcus granulosus	Tubulin alpha 1 chain	0.0121	0.041	0.4201
Schistosoma mansoni	serine/threonine protein kinase	0.0065	0.013	0.1165
Schistosoma mansoni	tubulin subunit epsilon	0.0065	0.0131	0.1181
Echinococcus multilocularis	tubulin subunit TubB	0.0121	0.041	0.4201
Schistosoma mansoni	tubulin subunit beta	0.0065	0.0131	0.1181
Echinococcus multilocularis	tubulin epsilon chain	0.0065	0.0131	0.1267
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.0065	0.013	0.136
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0068	0.0344
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0121	0.041	0.2086
Loa Loa (eye worm)	tubulin alpha 2	0.0093	0.0269	0.1369
Schistosoma mansoni	tubulin subunit beta	0.0065	0.0131	0.1181
Plasmodium falciparum	tubulin gamma chain	0.0065	0.0131	0.0005
Brugia malayi	SWIRM domain containing protein	0.0144	0.0525	0.2628
Leishmania major	beta tubulin	0.0065	0.0131	0.0041
Schistosoma mansoni	amine oxidase	0.0144	0.0525	0.5042
Echinococcus granulosus	tubulin alpha chain	0.0121	0.041	0.4201
Loa Loa (eye worm)	tubulin beta-4 chain	0.0065	0.0131	0.0669
Plasmodium vivax	tubulin alpha chain, putative	0.0121	0.041	0.0828
Schistosoma mansoni	serine/threonine protein kinase	0.0065	0.013	0.1165
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0055	0.0079	0.0713
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0065	0.0131	0.3207
Echinococcus multilocularis	tubulin alpha	0.0065	0.0131	0.1267
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.0065	0.013	0.136
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0144	0.0525	0.1167
Loa Loa (eye worm)	hypothetical protein	0.0144	0.0525	0.267
Loa Loa (eye worm)	beta-tubulin	0.0065	0.0131	0.0669
Trypanosoma brucei	alpha tubulin	0.0121	0.041	1
Brugia malayi	Tubulin beta-1 chain	0.0065	0.0131	0.0616
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0121	0.041	1
Loa Loa (eye worm)	tubulin beta-1 chain	0.0065	0.0131	0.0669
Echinococcus granulosus	Tubulin alpha 1 chain	0.0121	0.041	0.4201
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0084	0.0226	0.552
Schistosoma mansoni	serine/threonine protein kinase	0.0055	0.0079	0.0664
Brugia malayi	Tubulin alpha-2 chain	0.0121	0.041	0.2041
Echinococcus multilocularis	Tubulin beta 2C chain	0.0065	0.0131	0.1267
Schistosoma mansoni	serine/threonine protein kinase	0.0065	0.0129	0.1152
Schistosoma mansoni	3-dehydroquinate synthase	0.0126	0.0437	0.4179
Echinococcus multilocularis	tubulin alpha 1C chain	0.0121	0.041	0.4201
Loa Loa (eye worm)	tubulin alpha 2	0.0093	0.0269	0.1369
Mycobacterium ulcerans	chorismate synthase	0.0744	0.3514	0.3218
Loa Loa (eye worm)	alpha-tubulin	0.0121	0.041	0.2086
Toxoplasma gondii	beta-tubulin, putative	0.0065	0.0131	0.0005
Leishmania major	UDP-galactopyranose mutase	0.0144	0.0525	1
Leishmania major	beta tubulin	0.0065	0.0131	0.0041
Plasmodium falciparum	chorismate synthase	0.0744	0.3514	1
Toxoplasma gondii	histone lysine-specific demethylase	0.0144	0.0525	0.1167
Leishmania major	beta tubulin	0.0065	0.0131	0.0041
Loa Loa (eye worm)	STE/STE20/MSN protein kinase	0.0065	0.0129	0.0654
Schistosoma mansoni	tubulin subunit gamma	0.0065	0.0131	0.1181
Loa Loa (eye worm)	tubulin alpha chain	0.0121	0.041	0.2086
Echinococcus granulosus	Tubulin beta 2C chain	0.0065	0.0131	0.1267
Trichomonas vaginalis	tubulin beta chain, putative	0.0121	0.041	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0068	0.0344
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.2045	1	1
Plasmodium falciparum	tubulin epsilon chain, putative	0.0065	0.0131	0.0005
Schistosoma mansoni	serine/threonine protein kinase	0.0117	0.0392	0.3736
Loa Loa (eye worm)	hypothetical protein	0.0121	0.041	0.2086
Echinococcus granulosus	casein kinase I gamma	0.0065	0.0129	0.1237
Trypanosoma cruzi	epsilon tubulin, putative	0.0065	0.0131	0.1396
Mycobacterium ulcerans	dehydrogenase	0.0144	0.0525	0.0092
Schistosoma mansoni	alpha tubulin	0.0121	0.041	0.3914
Echinococcus granulosus	tubulin alpha	0.0065	0.0131	0.1267
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0055	0.0079	0.0713
Giardia lamblia	Beta tubulin	0.0065	0.0131	0.3017
Giardia lamblia	Gamma tubulin	0.0065	0.0131	0.3017
Mycobacterium tuberculosis	Probable chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase)	0.0367	0.1635	0.1354
Echinococcus multilocularis	tubulin alpha 1C chain	0.0121	0.041	0.4201
Loa Loa (eye worm)	BEN-1 protein	0.0065	0.0131	0.0669
Echinococcus multilocularis	tubulin alpha chain	0.0121	0.041	0.4201
Trypanosoma brucei	alpha tubulin	0.0121	0.041	1
Leishmania major	alpha tubulin	0.0121	0.041	0.7091
Schistosoma mansoni	rap gtpase-activating protein	0.0052	0.0068	0.0554
Leishmania major	alpha tubulin	0.0121	0.041	0.7091
Brugia malayi	Uncharacterized hematopoietic stem/progenitor cells protein MDS029	0.0098	0.0297	0.1464
Leishmania major	beta tubulin	0.0065	0.0131	0.0041
Schistosoma mansoni	tubulin subunit beta	0.0065	0.0131	0.1181
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0093	0.0269	0.6562
Brugia malayi	beta-tubulin, identical	0.0065	0.0131	0.0616
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0055	0.0079	0.0713
Trypanosoma brucei	epsilon tubulin	0.0065	0.0131	0.1864
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0121	0.041	1
Mycobacterium ulcerans	oxidoreductase	0.0144	0.0525	0.0092
Echinococcus multilocularis	beta tubulin	0.0065	0.0131	0.1267
Trypanosoma brucei	beta tubulin	0.0065	0.0131	0.1864
Echinococcus granulosus	beta tubulin	0.0065	0.0131	0.1267
Trichomonas vaginalis	tubulin gamma chain, putative	0.0065	0.0131	0.3207
Brugia malayi	probable protein kinase	0.0117	0.0389	0.1935
Trichomonas vaginalis	tubulin beta chain, putative	0.0065	0.0131	0.3207
Brugia malayi	tubulin alpha chain - mouse	0.0121	0.041	0.2041
Leishmania major	gamma-tubulin	0.0065	0.0131	0.0041
Echinococcus granulosus	Tubulin beta 2C chain	0.0065	0.0131	0.1267
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0121	0.041	0.4201
Brugia malayi	Temporarily assigned gene name protein 59	0.0052	0.0068	0.0289
Echinococcus granulosus	tubulin alpha chain	0.0121	0.041	0.4201
Trichomonas vaginalis	CMGC family protein kinase	0.0065	0.013	0.3168
Leishmania major	beta tubulin	0.0065	0.0131	0.0041
Trichomonas vaginalis	tubulin gamma chain, putative	0.0065	0.0131	0.3207
Leishmania major	beta tubulin	0.0065	0.0131	0.0041
Trypanosoma brucei	alpha tubulin	0.0121	0.041	1
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0144	0.0525	0.5411
Brugia malayi	Protein kinase domain containing protein	0.0065	0.013	0.0607
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0144	0.0525	0.1167
Echinococcus multilocularis	tubulin alpha chain	0.0121	0.041	0.4201
Echinococcus multilocularis	Tubulin beta 2C chain	0.0065	0.0131	0.1267
Echinococcus multilocularis	tubulin alpha chain	0.0121	0.041	0.4201
Echinococcus multilocularis	tubulin alpha 3 chain	0.0121	0.041	0.4201
Echinococcus granulosus	cdgsh iron sulfur domain containing protein	0.0231	0.096	1
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0144	0.0525	0.5411
Schistosoma mansoni	protein kinase	0.017	0.0652	0.6295
Echinococcus granulosus	dual specificity protein kinase clk2	0.0065	0.013	0.125
Schistosoma mansoni	tubulin subunit beta	0.0065	0.0131	0.1181
Leishmania major	alpha tubulin	0.0121	0.041	0.7091
Onchocerca volvulus		0.0098	0.0297	0.5024
Mycobacterium ulcerans	monoamine oxidase	0.0144	0.0525	0.0092
Schistosoma mansoni	mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3	0.0052	0.0068	0.0554
Leishmania major	alpha tubulin	0.0121	0.041	0.7091
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0065	0.0131	0.1267
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.0065	0.013	0.136
Trichomonas vaginalis	STE family protein kinase	0.0041	0.0011	0.0273
Brugia malayi	hypothetical protein	0.0144	0.0525	0.2628
Echinococcus granulosus	hypothetical protein	0.0063	0.0119	0.1133
Mycobacterium tuberculosis	Possible oxidoreductase	0.0144	0.0525	0.0099
Giardia lamblia	Beta tubulin	0.0065	0.0131	0.3017
Leishmania major	alpha tubulin	0.0121	0.041	0.7091
Echinococcus granulosus	protein kinase	0.0065	0.0129	0.1237
Echinococcus granulosus	tubulin epsilon chain	0.0065	0.0131	0.1267
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0144	0.0525	1
Leishmania major	beta tubulin	0.0065	0.0131	0.0041
Schistosoma mansoni	CDGSH-type Zn finger-containing protein-like protein	0.0245	0.103	1
Brugia malayi	hypothetical protein	0.0052	0.0068	0.0289
Trichomonas vaginalis	STE family protein kinase	0.0041	0.0011	0.0273
Trypanosoma brucei	beta tubulin	0.0065	0.0131	0.1864
Brugia malayi	Tubulin gamma chain	0.0065	0.0131	0.0616
Schistosoma mansoni	tubulin subunit alpha	0.0121	0.041	0.3914
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0144	0.0525	0.1167
Echinococcus multilocularis	tubulin beta 1 chain	0.0065	0.0131	0.1267
Echinococcus multilocularis		0.0065	0.0129	0.1237
Giardia lamblia	Alpha-tubulin	0.0121	0.041	1
Echinococcus multilocularis		0.0063	0.0119	0.1133
Trichomonas vaginalis	STE family protein kinase	0.0041	0.0011	0.0273
Echinococcus granulosus	tubulin alpha chain	0.0121	0.041	0.4201
Loa Loa (eye worm)	tubulin alpha chain	0.0121	0.041	0.2086
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0121	0.041	0.4201
Leishmania major	alpha tubulin	0.0121	0.041	0.7091
Echinococcus granulosus	tubulin alpha 3 chain	0.0121	0.041	0.4201
Plasmodium vivax	tubulin alpha chain, putative	0.0121	0.041	0.0828
Brugia malayi	Tubulin alpha chain	0.0121	0.041	0.2041
Trypanosoma brucei	kinetoplastid kinetochore protein 10	0.0065	0.013	0.1817
Loa Loa (eye worm)	tubulin alpha 2	0.0056	0.0085	0.0434
Plasmodium falciparum	tubulin beta chain	0.0065	0.0131	0.0005
Echinococcus granulosus	tubulin alpha 1C chain	0.0121	0.041	0.4201
Leishmania major	beta tubulin	0.0065	0.0131	0.0041
Echinococcus granulosus	beta tubulin	0.0065	0.0131	0.1267
Echinococcus granulosus	tubulin gamma 1 chain	0.0065	0.0131	0.1267
Leishmania major	alpha tubulin	0.0121	0.041	0.7091
Echinococcus multilocularis	beta tubulin	0.0065	0.0131	0.1267
Echinococcus granulosus	peroxisome assembly protein 26	0.0121	0.041	0.4201
Brugia malayi	alpha-tubulin	0.0121	0.041	0.2041
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0065	0.0129	0.0654
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.0144	0.0525	0.0092
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0144	0.0525	0.0099
Leishmania major	beta tubulin	0.0065	0.0131	0.0041
Schistosoma mansoni	protein kinase	0.0065	0.0129	0.1152
Loa Loa (eye worm)	hypothetical protein	0.0144	0.0525	0.267
Echinococcus granulosus	tubulin alpha chain	0.0121	0.041	0.4201
Schistosoma mansoni	protein kinase	0.0117	0.0389	0.3712

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)	= 58 %	Inhibition of CXCL8-induced chemotaxis of human polymorphonuclear cells at 10e-8 M	ChEMBL.	15974585
Inhibition (functional)	= 58 %	Inhibition of CXCL8-induced chemotaxis of human polymorphonuclear cells at 10e-8 M	ChEMBL.	15974585

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 332065