Detailed information for compound 332958

Basic information

Technical information
  • TDR Targets ID: 332958
  • Name: 2-(3-butylphenyl)propanoic acid
  • MW: 206.281 | Formula: C13H18O2
  • H donors: 1 H acceptors: 2 LogP: 3.84 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCc1cccc(c1)C(C(=O)O)C
  • InChi: 1S/C13H18O2/c1-3-4-6-11-7-5-8-12(9-11)10(2)13(14)15/h5,7-10H,3-4,6H2,1-2H3,(H,14,15)
  • InChiKey: RYDHTZRQIQMPSZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(3-butylphenyl)propionic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis peroxisome assembly protein 26 0.0121 0.041 0.4201
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0055 0.0079 0.0713
Toxoplasma gondii beta-1 tubulin, putative 0.0065 0.0131 0.0005
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0144 0.0525 0.5042
Toxoplasma gondii beta tubulin 0.0065 0.0131 0.0005
Mycobacterium ulcerans dehydrogenase 0.0144 0.0525 0.0092
Leishmania major alpha tubulin 0.0121 0.041 0.7091
Leishmania major alpha tubulin 0.0121 0.041 0.7091
Loa Loa (eye worm) hypothetical protein 0.0052 0.0068 0.0344
Echinococcus granulosus Tubulin beta 2C chain 0.0065 0.0131 0.1267
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0052 0.0068 0.0595
Plasmodium vivax tubulin gamma chain, putative 0.0065 0.0131 0.0005
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0144 0.0525 0.5042
Loa Loa (eye worm) beta-tubulin 0.0065 0.0131 0.0669
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0115 0.0378 0.3866
Trypanosoma brucei epsilon tubulin 0.0065 0.0131 0.1864
Echinococcus multilocularis Tubulin alpha 1 chain 0.0121 0.041 0.4201
Toxoplasma gondii alpha tubulin TUBA1 0.0121 0.041 0.0828
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0065 0.013 0.136
Echinococcus multilocularis protoporphyrinogen oxidase 0.0144 0.0525 0.5411
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0052 0.0068 0.0595
Leishmania major beta tubulin 0.0065 0.0131 0.0041
Echinococcus multilocularis tubulin gamma 1 chain 0.0065 0.0131 0.1267
Echinococcus multilocularis tubulin alpha 1C chain 0.0121 0.041 0.4201
Echinococcus multilocularis tubulin alpha chain 0.0121 0.041 0.4201
Loa Loa (eye worm) hypothetical protein 0.0063 0.0119 0.0604
Schistosoma mansoni tubulin subunit alpha 0.0121 0.041 0.3914
Loa Loa (eye worm) hypothetical protein 0.0052 0.0068 0.0344
Giardia lamblia Alpha-tubulin 0.0121 0.041 1
Leishmania major beta tubulin 0.0065 0.0131 0.0041
Echinococcus granulosus peroxisome assembly protein 26 0.0121 0.041 0.4201
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.013 0.1165
Plasmodium vivax hypothetical protein, conserved 0.0144 0.0525 0.1167
Trichomonas vaginalis tubulin beta chain, putative 0.0121 0.041 1
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0065 0.013 0.1817
Echinococcus granulosus beta tubulin 0.0065 0.0131 0.1267
Loa Loa (eye worm) hypothetical protein 0.0115 0.0378 0.1924
Trichomonas vaginalis tubulin epsilon chain, putative 0.0121 0.041 1
Mycobacterium ulcerans oxidoreductase 0.0144 0.0525 0.0092
Giardia lamblia Beta tubulin 0.0065 0.0131 0.3017
Giardia lamblia Gamma tubulin 0.0065 0.0131 0.3017
Loa Loa (eye worm) hypothetical protein 0.0084 0.0226 0.1151
Schistosoma mansoni CDGSH-type Zn finger-containing protein-like protein 0.0245 0.103 1
Echinococcus granulosus tubulin alpha 0.0065 0.0131 0.1267
Onchocerca volvulus 0.0144 0.0525 1
Brugia malayi Tubulin alpha-2 chain 0.0121 0.041 0.2041
Leishmania major alpha tubulin 0.0121 0.041 0.7091
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0144 0.0525 0.1167
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0325 0.1425 0.1033
Loa Loa (eye worm) protein kinase domain-containing protein 0.0065 0.0129 0.0654
Onchocerca volvulus 0.0098 0.0297 0.5024
Echinococcus granulosus cdgsh iron sulfur domain containing protein 0.0231 0.096 1
Toxoplasma gondii chorismate synthase, putative 0.0744 0.3514 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0065 0.0131 0.1267
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0079 0.0664
Leishmania major beta tubulin 0.0065 0.0131 0.0041
Echinococcus multilocularis Tubulin beta 2C chain 0.0065 0.0131 0.1267
Leishmania major beta tubulin 0.0065 0.0131 0.0041
Echinococcus multilocularis 0.0144 0.0525 0.5411
Leishmania major beta tubulin 0.0065 0.0131 0.0041
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0084 0.0226 0.552
Echinococcus granulosus protein kinase 0.0065 0.0129 0.1237
Echinococcus granulosus Tubulin beta 2C chain 0.0065 0.0131 0.1267
Brugia malayi Tubulin alpha-2 chain 0.0121 0.041 0.2041
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0055 0.0079 0.0713
Trichomonas vaginalis tubulin beta chain, putative 0.0121 0.041 1
Leishmania major beta tubulin 0.0065 0.0131 0.0041
Mycobacterium tuberculosis Possible oxidoreductase 0.0144 0.0525 0.0099
Leishmania major beta tubulin 0.0065 0.0131 0.0041
Trypanosoma brucei beta tubulin 0.0065 0.0131 0.1864
Brugia malayi Protein kinase domain containing protein 0.017 0.0652 0.3282
Trichomonas vaginalis STE family protein kinase 0.0041 0.0011 0.0273
Trypanosoma brucei beta tubulin 0.0065 0.0131 0.1864
Echinococcus granulosus tubulin alpha 1C chain 0.0121 0.041 0.4201
Leishmania major UDP-galactopyranose mutase 0.0144 0.0525 1
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0065 0.0131 0.1267
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0144 0.0525 0.1167
Leishmania major alpha tubulin 0.0121 0.041 0.7091
Trichomonas vaginalis tubulin beta chain, putative 0.0121 0.041 1
Echinococcus granulosus dual specificity protein kinase clk2 0.0065 0.013 0.125
Echinococcus multilocularis tubulin alpha 1C chain 0.0121 0.041 0.4201
Leishmania major beta tubulin 0.0065 0.0131 0.0041
Giardia lamblia Kinase, CMGC CLK 0.0065 0.013 0.2976
Loa Loa (eye worm) alpha-tubulin 0.0121 0.041 0.2086
Leishmania major alpha tubulin 0.0121 0.041 0.7091
Echinococcus granulosus tubulin alpha chain 0.0121 0.041 0.4201
Trypanosoma cruzi beta tubulin, putative 0.0065 0.0131 0.1396
Trypanosoma brucei alpha tubulin 0.0121 0.041 1
Brugia malayi Protein kinase domain containing protein 0.0065 0.013 0.0607
Echinococcus granulosus tubulin alpha chain 0.0121 0.041 0.4201
Trichomonas vaginalis STE family protein kinase 0.0041 0.0011 0.0273
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0065 0.013 0.0661
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0079 0.0664
Schistosoma mansoni tubulin subunit beta 0.0065 0.0131 0.1181
Entamoeba histolytica tubulin family protein 0.0065 0.0131 0.3017
Echinococcus multilocularis beta tubulin 0.0065 0.0131 0.1267
Echinococcus multilocularis Tubulin alpha 1 chain 0.0121 0.041 0.4201
Brugia malayi Protein kinase domain containing protein 0.0433 0.1965 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0121 0.041 0.4201
Trypanosoma brucei alpha tubulin 0.0121 0.041 1
Schistosoma mansoni serine/threonine protein kinase 0.0117 0.0392 0.3736
Trichomonas vaginalis tubulin gamma chain, putative 0.0065 0.0131 0.3207
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0052 0.0068 0.0554
Echinococcus granulosus tubulin beta 1 chain 0.0065 0.0131 0.1267
Echinococcus granulosus Tubulin beta 2C chain 0.0065 0.0131 0.1267
Mycobacterium ulcerans monoamine oxidase 0.0144 0.0525 0.0092
Mycobacterium leprae Chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase). 0.0367 0.1635 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0121 0.041 1
Loa Loa (eye worm) tubulin alpha chain 0.0121 0.041 0.2086
Loa Loa (eye worm) hypothetical protein 0.0144 0.0525 0.267
Schistosoma mansoni amine oxidase 0.0144 0.0525 0.5042
Plasmodium vivax tubulin epsilon chain, putative 0.0065 0.0131 0.0005
Plasmodium falciparum tubulin beta chain 0.0065 0.0131 0.0005
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0065 0.0131 0.0005
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0144 0.0525 0.1167
Trichomonas vaginalis STE family protein kinase 0.0041 0.0011 0.0273
Trichomonas vaginalis tubulin beta chain, putative 0.0121 0.041 1
Echinococcus multilocularis 0.0063 0.0119 0.1133
Echinococcus granulosus hypothetical protein 0.0063 0.0119 0.1133
Leishmania major alpha tubulin 0.0121 0.041 0.7091
Schistosoma mansoni tubulin subunit beta 0.0065 0.0131 0.1181
Chlamydia trachomatis UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0198 0.0795 0.1165
Loa Loa (eye worm) alpha-tubulin 0.0121 0.041 0.2086
Trypanosoma brucei alpha tubulin 0.0121 0.041 1
Echinococcus multilocularis 0.0065 0.0129 0.1237
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0325 0.1425 0.3828
Toxoplasma gondii beta-tubulin, putative 0.0065 0.0131 0.0005
Leishmania major beta tubulin 0.0065 0.0131 0.0041
Echinococcus granulosus Tubulin beta 2C chain 0.0065 0.0131 0.1267
Brugia malayi probable protein kinase 0.0117 0.0389 0.1935
Trypanosoma cruzi tubulin gamma chain 0.0065 0.0131 0.1396
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0055 0.0079 0.0713
Brugia malayi Protein kinase domain containing protein 0.0065 0.0129 0.0601
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.017 0.0652 0.6756
Trypanosoma brucei beta tubulin 0.0065 0.0131 0.1864
Schistosoma mansoni hypothetical protein 0.0245 0.103 1
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0055 0.0079 0.0713
Schistosoma mansoni alpha tubulin 0.0121 0.041 0.3914
Plasmodium falciparum protoporphyrinogen oxidase 0.0144 0.0525 0.1167
Brugia malayi amine oxidase, flavin-containing family protein 0.0144 0.0525 0.2628
Echinococcus multilocularis casein kinase I gamma 0.0065 0.0129 0.1237
Plasmodium falciparum alpha tubulin 2 0.0121 0.041 0.0828
Loa Loa (eye worm) BEN-1 protein 0.0065 0.0131 0.0669
Brugia malayi Tubulin gamma chain 0.0065 0.0131 0.0616
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.1901 0.9282 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0144 0.0525 0.0099
Echinococcus granulosus tubulin alpha 3 chain 0.0121 0.041 0.4201
Loa Loa (eye worm) tubulin gamma chain 0.0065 0.0131 0.0669
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.2045 1 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0065 0.0131 0.1267
Brugia malayi tubulin alpha-2 chain 0.0121 0.041 0.2041
Leishmania major beta tubulin 0.0065 0.0131 0.0041
Trypanosoma brucei epsilon tubulin 0.0065 0.0131 0.1864
Echinococcus multilocularis cdgsh iron sulfur domain containing protein 0.0231 0.096 1
Plasmodium falciparum tubulin epsilon chain, putative 0.0065 0.0131 0.0005
Brugia malayi Temporarily assigned gene name protein 59 0.0052 0.0068 0.0289
Trichomonas vaginalis CMGC family protein kinase 0.0065 0.013 0.3168
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0052 0.0068 0.0554
Echinococcus granulosus Tubulin alpha 1 chain 0.0121 0.041 0.4201
Leishmania major alpha tubulin 0.0121 0.041 0.7091
Schistosoma mansoni tubulin subunit beta 0.0065 0.0131 0.1181
Brugia malayi alpha-tubulin 0.0121 0.041 0.2041
Leishmania major beta tubulin 0.0065 0.0131 0.0041
Schistosoma mansoni tubulin subunit gamma 0.0065 0.0131 0.1181
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0065 0.013 0.136
Trypanosoma brucei beta tubulin 0.0065 0.0131 0.1864
Entamoeba histolytica tubulin family protein 0.0065 0.0131 0.3017
Echinococcus granulosus tubulin alpha chain 0.0121 0.041 0.4201
Leishmania major alpha tubulin 0.0121 0.041 0.7091
Trypanosoma cruzi UDP-galactopyranose mutase 0.0144 0.0525 1
Leishmania major alpha tubulin 0.0121 0.041 0.7091
Schistosoma mansoni protein kinase 0.0065 0.0129 0.1152
Echinococcus multilocularis Tubulin beta 2C chain 0.0065 0.0131 0.1267
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0198 0.0795 0.5
Echinococcus multilocularis tubulin alpha chain 0.0121 0.041 0.4201
Echinococcus granulosus lysine specific histone demethylase 1A 0.0144 0.0525 0.5411
Schistosoma mansoni tubulin subunit beta 0.0065 0.0131 0.1181
Entamoeba histolytica tubulin alpha-1 chain 0.0121 0.041 1
Echinococcus multilocularis hypothetical protein 0.0121 0.041 0.4201
Leishmania major beta tubulin 0.0065 0.0131 0.0041
Loa Loa (eye worm) tubulin alpha 2 0.0056 0.0085 0.0434
Echinococcus multilocularis dual specificity protein kinase clk2 0.0065 0.013 0.125
Echinococcus multilocularis tubulin alpha chain 0.0121 0.041 0.4201
Echinococcus multilocularis tubulin alpha 0.0065 0.0131 0.1267
Trypanosoma cruzi UDP-galactopyranose mutase 0.0144 0.0525 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0068 0.0344
Echinococcus granulosus beta tubulin 0.0065 0.0131 0.1267
Brugia malayi Tubulin beta-1 chain 0.0065 0.0131 0.0616
Loa Loa (eye worm) tubulin beta-1 chain 0.0065 0.0131 0.0669
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.017 0.0652 0.6756
Echinococcus multilocularis tubulin epsilon chain 0.0065 0.0131 0.1267
Leishmania major beta tubulin 0.0065 0.0131 0.0041
Loa Loa (eye worm) tubulin alpha-2 chain 0.0121 0.041 0.2086
Loa Loa (eye worm) tubulin beta-4 chain 0.0065 0.0131 0.0669
Schistosoma mansoni 3-dehydroquinate synthase 0.0126 0.0437 0.4179
Trichomonas vaginalis tubulin alpha chain, putative 0.0065 0.0131 0.3207
Leishmania major alpha tubulin 0.0121 0.041 0.7091
Echinococcus multilocularis tubulin beta 1 chain 0.0065 0.0131 0.1267
Mycobacterium ulcerans chorismate synthase 0.0744 0.3514 0.3218
Loa Loa (eye worm) tubulin beta chain 0.0065 0.0131 0.0669
Trichomonas vaginalis tubulin, putative 0.0065 0.0131 0.3207
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.013 0.1165
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0093 0.0269 0.1369
Trichomonas vaginalis tubulin epsilon chain, putative 0.0065 0.0131 0.3207
Leishmania major alpha tubulin 0.0121 0.041 0.7091
Giardia lamblia Beta tubulin 0.0065 0.0131 0.3017
Schistosoma mansoni tubulin subunit alpha 0.0121 0.041 0.3914
Loa Loa (eye worm) tubulin alpha chain 0.0121 0.041 0.2086
Echinococcus granulosus lysine specific histone demethylase 1A 0.0144 0.0525 0.5411
Echinococcus granulosus Tubulin beta 2C chain 0.0065 0.0131 0.1267
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0144 0.0525 0.5411
Loa Loa (eye worm) casein kinase 0.0062 0.0117 0.0597
Echinococcus multilocularis tubulin alpha 3 chain 0.0121 0.041 0.4201
Echinococcus multilocularis tubulin alpha chain 0.0121 0.041 0.4201
Loa Loa (eye worm) hypothetical protein 0.0144 0.0525 0.267
Echinococcus multilocularis tubulin alpha 3 chain 0.0121 0.041 0.4201
Brugia malayi SWIRM domain containing protein 0.0144 0.0525 0.2628
Trypanosoma brucei beta tubulin 0.0065 0.0131 0.1864
Leishmania major alpha tubulin 0.0121 0.041 0.7091
Brugia malayi beta-tubulin, identical 0.0065 0.0131 0.0616
Trichomonas vaginalis tubulin beta chain, putative 0.0121 0.041 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0065 0.0131 0.3207
Schistosoma mansoni tubulin subunit beta 0.0065 0.0131 0.1181
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0093 0.0269 0.6562
Toxoplasma gondii alpha-tubulin I, putative 0.0121 0.041 0.0828
Echinococcus granulosus tubulin alpha chain 0.0121 0.041 0.4201
Echinococcus multilocularis tubulin subunit TubB 0.0121 0.041 0.4201
Echinococcus granulosus tubulin alpha 3 chain 0.0121 0.041 0.4201
Echinococcus granulosus Vam6:Vps39 protein 0.0052 0.0068 0.0595
Echinococcus granulosus tubulin subunit beta 0.0065 0.0131 0.1267
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0325 0.1425 0.3212
Brugia malayi hypothetical protein 0.0052 0.0068 0.0289
Schistosoma mansoni vam6/vps39 related 0.0052 0.0068 0.0554
Echinococcus multilocularis beta tubulin 0.0065 0.0131 0.1267
Echinococcus multilocularis Tubulin beta 2C chain 0.0065 0.0131 0.1267
Plasmodium falciparum alpha tubulin 1 0.0121 0.041 0.0828
Schistosoma mansoni alpha tubulin 0.0121 0.041 0.3914
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0129 0.1152
Plasmodium vivax chorismate synthase 0.0744 0.3514 1
Loa Loa (eye worm) BEN-1 protein 0.0065 0.0131 0.0669
Schistosoma mansoni amine oxidase 0.0144 0.0525 0.5042
Brugia malayi Uncharacterized hematopoietic stem/progenitor cells protein MDS029 0.0098 0.0297 0.1464
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0198 0.0795 0.5
Plasmodium vivax tubulin beta chain, putative 0.0065 0.0131 0.0005
Loa Loa (eye worm) tubulin beta-2A chain 0.0065 0.0131 0.0669
Trichomonas vaginalis tubulin beta chain, putative 0.0121 0.041 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.0297 0.1513
Mycobacterium tuberculosis Probable chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase) 0.0367 0.1635 0.1354
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.017 0.0652 0.332
Trypanosoma brucei alpha tubulin 0.0121 0.041 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0121 0.041 0.4201
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0121 0.041 1
Leishmania major beta tubulin 0.0065 0.0131 0.0041
Trichomonas vaginalis tubulin epsilon chain, putative 0.0065 0.0131 0.3207
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0144 0.0525 0.1167
Plasmodium vivax tubulin alpha chain, putative 0.0121 0.041 0.0828
Leishmania major beta tubulin 0.0065 0.0131 0.0041
Trypanosoma brucei epsilon tubulin 0.0065 0.0131 0.1864
Echinococcus granulosus alpha tubulin 0.0121 0.041 0.4201
Schistosoma mansoni tubulin subunit epsilon 0.0065 0.0131 0.1181
Toxoplasma gondii histone lysine-specific demethylase 0.0144 0.0525 0.1167
Loa Loa (eye worm) tubulin alpha 2 0.0093 0.0269 0.1369
Entamoeba histolytica tubulin gamma chain 0.0065 0.0131 0.3017
Leishmania major gamma-tubulin 0.0065 0.0131 0.0041
Chlamydia trachomatis protoporphyrinogen oxidase 0.0144 0.0525 0.0286
Trichomonas vaginalis STE family protein kinase 0.0041 0.0011 0.0273
Echinococcus multilocularis tubulin subunit beta 0.0065 0.0131 0.1267
Trichomonas vaginalis tubulin beta chain, putative 0.0065 0.0131 0.3207
Brugia malayi Tubulin alpha chain 0.0121 0.041 0.2041
Schistosoma mansoni tubulin subunit alpha 0.0121 0.041 0.3914
Leishmania major beta tubulin 0.0065 0.0131 0.0041
Loa Loa (eye worm) hypothetical protein 0.0144 0.0525 0.267
Echinococcus multilocularis tubulin alpha chain 0.0121 0.041 0.4201
Echinococcus granulosus casein kinase I gamma 0.0065 0.0129 0.1237
Schistosoma mansoni hypothetical protein 0.0052 0.0068 0.0554
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0144 0.0525 0.0092
Plasmodium falciparum chorismate synthase 0.0744 0.3514 1
Trypanosoma cruzi epsilon tubulin, putative 0.0065 0.0131 0.1396
Schistosoma mansoni rap gtpase-activating protein 0.0052 0.0068 0.0554
Schistosoma mansoni alpha tubulin 0.0121 0.041 0.3914
Trypanosoma brucei tubulin gamma chain 0.0065 0.0131 0.1864
Echinococcus granulosus tubulin alpha chain 0.0121 0.041 0.4201
Leishmania major beta tubulin 0.0065 0.0131 0.0041
Echinococcus granulosus tubulin epsilon chain 0.0065 0.0131 0.1267
Echinococcus granulosus tubulin alpha 1C chain 0.0121 0.041 0.4201
Loa Loa (eye worm) hypothetical protein 0.0144 0.0525 0.267
Loa Loa (eye worm) hypothetical protein 0.0144 0.0525 0.267
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0144 0.0525 0.1167
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0065 0.013 0.136
Trichomonas vaginalis tubulin gamma chain, putative 0.0065 0.0131 0.3207
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0433 0.1965 1
Entamoeba histolytica tubulin alpha chain, putative 0.0121 0.041 1
Giardia lamblia Alpha-tubulin 0.0121 0.041 1
Leishmania major beta tubulin 0.0065 0.0131 0.0041
Schistosoma mansoni protein kinase 0.0117 0.0389 0.3712
Leishmania major epsilon tubulin, putative 0.0065 0.0131 0.0041
Plasmodium vivax hypothetical protein, conserved 0.0144 0.0525 0.1167
Echinococcus multilocularis Tubulin alpha 1 chain 0.0121 0.041 0.4201
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0144 0.0525 0.0734
Plasmodium falciparum tubulin gamma chain 0.0065 0.0131 0.0005
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0065 0.013 0.136
Loa Loa (eye worm) tubulin alpha 2 0.0093 0.0269 0.1369
Schistosoma mansoni protein kinase 0.017 0.0652 0.6295
Echinococcus granulosus tubulin gamma 1 chain 0.0065 0.0131 0.1267
Trypanosoma cruzi epsilon tubulin, putative 0.0065 0.0131 0.1396
Loa Loa (eye worm) tubulin alpha-3 chain 0.0084 0.0226 0.1151
Trichomonas vaginalis tubulin gamma chain, putative 0.0065 0.0131 0.3207
Echinococcus granulosus tubulin subunit TubB 0.0121 0.041 0.4201
Brugia malayi tubulin alpha chain - mouse 0.0121 0.041 0.2041
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0065 0.013 0.1817
Loa Loa (eye worm) hypothetical protein 0.0121 0.041 0.2086
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0325 0.1425 0.8249
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0065 0.0129 0.0654
Plasmodium vivax tubulin alpha chain, putative 0.0121 0.041 0.0828
Schistosoma mansoni tubulin subunit beta 0.0065 0.0131 0.1181
Trypanosoma cruzi alpha tubulin, putative 0.0121 0.041 0.7487
Brugia malayi hypothetical protein 0.0144 0.0525 0.2628
Echinococcus granulosus tubulin beta 4A class IVa 0.0065 0.0131 0.1267
Loa Loa (eye worm) hypothetical protein 0.0093 0.0269 0.1369
Giardia lamblia Beta tubulin 0.0065 0.0131 0.3017
Loa Loa (eye worm) hypothetical protein 0.0144 0.0525 0.267
Chlamydia trachomatis chorismate synthase 0.0744 0.3514 1
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0198 0.0795 0.0375

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) 0 Inhibition of CXCL1-induced cell migration in human PMN cells at 0.01 uM by chemotaxis assay ChEMBL. 17665889
Inhibition (functional) 0 % Inhibition of CXCL8-induced chemotaxis of human polymorphonuclear cells at 10e-8 M: not active ChEMBL. 15974585
Inhibition (functional) = 3 % Inhibition of CXCL8-induced cell migration in human PMN cells at 0.01 uM by chemotaxis assay ChEMBL. 17665889

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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