Detailed information for compound 340101

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 435.645 | Formula: C28H41N3O
  • H donors: 1 H acceptors: 0 LogP: 5.28 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C(N1CCN(CC1)C1CCCCC1)CNCCc1ccc(cc1)C
  • InChi: 1S/C28H41N3O/c1-23-8-10-24(11-9-23)16-17-29-22-28(25-12-14-27(32-2)15-13-25)31-20-18-30(19-21-31)26-6-4-3-5-7-26/h8-15,26,28-29H,3-7,16-22H2,1-2H3
  • InChiKey: ZZMPTQZANQVWEF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens chemokine (C-C motif) receptor 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0007 0.0003 0.0003
Brugia malayi Nuclear hormone receptor-like 1 0.0008 0.0004 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0015 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0017 0.0016 0.0265
Schistosoma mansoni lamin 0.0017 0.0016 0.0265
Echinococcus multilocularis beta LACTamase domain containing family member 0.0025 0.0026 0.0388
Brugia malayi ecdysteroid receptor 0.0015 0.0013 0.0018
Loa Loa (eye worm) MH2 domain-containing protein 0.0005 0.0001 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0015 0.0013 0.022
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0013 0.0197
Plasmodium falciparum ataxin-2 like protein, putative 0.0013 0.001 0.0021
Onchocerca volvulus 0.0007 0.0003 0.0003
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0015 0.0013 0.0018
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0478 0.0609 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0051
Leishmania major trypanothione reductase 0.0024 0.0025 0.0075
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0015 0.0013 0.022
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0025 0.0026 0.1102
Schistosoma mansoni phosphoglucomutase 0.0032 0.0036 0.0586
Trichomonas vaginalis D-aminoacylase, putative 0.0025 0.0026 0.185
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.0299 0.4394
Echinococcus granulosus histone lysine methyltransferase setb 0.0013 0.001 0.0153
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0026 0.008
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0009 0.0006 0.0096
Loa Loa (eye worm) hypothetical protein 0.0025 0.0026 0.0434
Loa Loa (eye worm) MH1 domain-containing protein 0.0005 0.0001 0.0011
Echinococcus granulosus protection of telomeres protein 1 0.0535 0.0681 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0055 0.0065 0.3066
Trichomonas vaginalis D-aminoacylase, putative 0.0025 0.0026 0.185
Brugia malayi Pre-SET motif family protein 0.0087 0.0106 0.0146
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0007 0.0003 0.0046
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0051
Schistosoma mansoni smad 0.0005 0.0001 0.0011
Brugia malayi hypothetical protein 0.0238 0.0299 0.0412
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0007 0.0003 0.0046
Brugia malayi Steroid receptor seven-up type 2 0.0015 0.0013 0.0018
Echinococcus granulosus lamin 0.0017 0.0016 0.0237
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0006 0.0002 0.0003
Leishmania major hypothetical protein, conserved 0.0013 0.001 0.0021
Echinococcus granulosus Smad4 0.0005 0.0001 0.001
Echinococcus multilocularis lamin dm0 0.0017 0.0016 0.0237
Plasmodium vivax thioredoxin reductase, putative 0.0024 0.0025 0.0075
Brugia malayi MH1 domain containing protein 0.0005 0.0001 0.0001
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0007 0.0003 0.0051
Brugia malayi MH2 domain containing protein 0.0005 0.0001 0.0001
Giardia lamblia Ribonuclease H 0.0032 0.0036 0.0114
Echinococcus multilocularis Smad4 0.0005 0.0001 0.001
Trypanosoma brucei ingi protein (ORF1) 0.0035 0.0039 0.0127
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0015 0.0013 0.0018
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0007 0.0003 0.0004
Brugia malayi hypothetical protein 0.0106 0.013 0.0178
Plasmodium falciparum ataxin-2 like protein, putative 0.0013 0.001 0.0021
Echinococcus multilocularis mothers against decapentaplegic 5 0.0005 0.0001 0.001
Echinococcus multilocularis smad 0.0005 0.0001 0.001
Trypanosoma brucei telomerase reverse transcriptase 0.2124 0.2726 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0051
Brugia malayi Nuclear hormone receptor E75 0.0007 0.0003 0.0004
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0007 0.0003 0.0051
Loa Loa (eye worm) hypothetical protein 0.0017 0.0016 0.0259
Onchocerca volvulus 0.0025 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0051
Schistosoma mansoni nuclear receptor 0.0007 0.0003 0.0051
Loa Loa (eye worm) Smad1 0.0005 0.0001 0.0011
Echinococcus granulosus thioredoxin glutathione reductase 0.0025 0.0026 0.0375
Mycobacterium tuberculosis Probable lipase LipD 0.0025 0.0026 0.1102
Treponema pallidum ribonuclease H (rnhA) 0.0032 0.0036 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.022
Loa Loa (eye worm) MH2 domain-containing protein 0.0076 0.0092 0.1514
Plasmodium vivax glutathione reductase, putative 0.0024 0.0025 0.0075
Brugia malayi nuclear hormone receptor family member nhr-6 0.0007 0.0003 0.0004
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0008 0.0005 0.5
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0051
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0061 0.0073 0.3469
Brugia malayi Nuclear hormone receptor-like 1 0.0008 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0171
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0015 0.0013 0.0197
Brugia malayi hypothetical protein 0.0008 0.0004 0.0006
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0013 0.001 0.0171
Echinococcus multilocularis thyroid hormone receptor alpha 0.0015 0.0013 0.0197
Loa Loa (eye worm) nuclear receptor NHR-67 0.0007 0.0003 0.0051
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0013 0.001 0.0153
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0015 0.0013 0.022
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0013 0.001 0.0021
Brugia malayi Smad1 0.0005 0.0001 0.0001
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0005 0.0001 0.0011
Brugia malayi nuclear receptor NHR-67 0.0007 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.022
Echinococcus multilocularis dnaJ subfamily B 0.0204 0.0257 0.3765
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0025 0.0026 0.1102
Loa Loa (eye worm) CXXC zinc finger family protein 0.0014 0.0012 0.0203
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0051
Echinococcus multilocularis geminin 0.0109 0.0134 0.1959
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0013 0.022
Brugia malayi hypothetical protein 0.0007 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0008 0.0004 0.007
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0026 0.008
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0015 0.0013 0.0013
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0005 0 0.0004
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0025 0.0026 0.0434
Echinococcus multilocularis lamin 0.0017 0.0016 0.0237
Schistosoma mansoni nuclear hormone receptor 0.0007 0.0003 0.0051
Schistosoma mansoni zinc finger protein 0.0007 0.0003 0.0051
Echinococcus multilocularis FTZ F1 alpha 0.0015 0.0013 0.0197
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0478 0.0609 0.8942
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0055 0.0065 0.3066
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0015 0.0013 0.022
Schistosoma mansoni nuclear receptor 0.0007 0.0003 0.0051
Loa Loa (eye worm) beta-lactamase 0.0025 0.0026 0.0434
Onchocerca volvulus 0.0017 0.0016 0.0016
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0013 0.001 0.0171
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0005 0 0.0004
Brugia malayi nuclear receptor NHR-88 0.0007 0.0003 0.0004
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0015 0.0013 0.0197
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0015 0.0013 0.0197
Schistosoma mansoni smad1 5 8 and 0.0005 0.0001 0.0011
Trypanosoma brucei PAB1-binding protein , putative 0.0013 0.001 0.0021
Mycobacterium ulcerans esterase/lipase LipP 0.0025 0.0026 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0007 0.0003 0.0046
Trypanosoma brucei ribonuclease H1 0.0032 0.0036 0.0114
Schistosoma mansoni hypothetical protein 0.0109 0.0134 0.2191
Schistosoma mansoni survival motor neuron protein 0.0048 0.0056 0.0923
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0008 0.0005 0.0007
Loa Loa (eye worm) steroid hormone receptor 0.0015 0.0013 0.022
Schistosoma mansoni retinoic acid receptor RXR 0.0015 0.0013 0.022
Brugia malayi tailless protein 0.0007 0.0003 0.0004
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0478 0.0609 0.8942
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0007 0.0003 0.0046
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0015 0.0013 0.0197
Leishmania major hypothetical protein, conserved 0.0025 0.0026 0.008
Trypanosoma brucei trypanothione reductase 0.0024 0.0025 0.0075
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0015 0.0013 0.0018
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0008 0.0004 0.0062
Schistosoma mansoni coup transcription factor 0.0015 0.0013 0.022
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0015 0.0013 0.0018
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.0299 0.4394
Giardia lamblia Telomerase catalytic subunit 0.2124 0.2726 1
Trypanosoma cruzi trypanothione reductase, putative 0.0024 0.0025 0.0075
Brugia malayi Pre-SET motif family protein 0.0013 0.001 0.0014
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.2124 0.2726 1
Schistosoma mansoni nuclear hormone receptor 0.0007 0.0003 0.0051
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0015 0.0013 0.022
Echinococcus granulosus beta LACTamase domain containing family member 0.0025 0.0026 0.0388
Schistosoma mansoni hypothetical protein 0.0106 0.013 0.2128
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0025 0.0026 0.0434
Echinococcus granulosus dnaJ subfamily B 0.0204 0.0257 0.3765
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0008 0.0005 0.0069
Brugia malayi MH2 domain containing protein 0.0076 0.0092 0.0127
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0007 0.0003 0.0003
Trichomonas vaginalis penicillin-binding protein, putative 0.0025 0.0026 0.185
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0478 0.0609 0.0839
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0061 0.0073 0.3469
Loa Loa (eye worm) hypothetical protein 0.0025 0.0026 0.0434
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0008 0.0004 0.007
Echinococcus granulosus nuclear receptor nhr 48 0.0007 0.0003 0.0046
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0015 0.0013 0.022
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.0045 0.0052 0.0853
Echinococcus granulosus lamin dm0 0.0017 0.0016 0.0237
Toxoplasma gondii histone lysine methyltransferase SET1 0.0028 0.0029 0.0091
Echinococcus granulosus Nuclear hormone receptor HR96 0.0007 0.0003 0.0046
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0026 0.008
Brugia malayi Nuclear hormone receptor E75 0.0007 0.0003 0.0004
Mycobacterium tuberculosis Probable esterase LipL 0.0025 0.0026 0.1102
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0031 0.0034 0.0552
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.017
Loa Loa (eye worm) hypothetical protein 0.0008 0.0004 0.007
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0015 0.0013 0.0018
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0017 0.0016 0.0265
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0007 0.0003 0.0051
Schistosoma mansoni lamin 0.0017 0.0016 0.0265
Brugia malayi cytoplasmic intermediate filament protein 0.0009 0.0006 0.0008
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0007 0.0003 0.0046
Brugia malayi hypothetical protein 0.0106 0.013 0.0178
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0061 0.0073 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0013 0.001 0.0021
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0013 0.0197
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0025 0.0026 0.0434
Trypanosoma brucei RNA helicase, putative 0.0527 0.0671 0.245
Onchocerca volvulus Protein ultraspiracle homolog 0.0015 0.0013 0.0013
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0008 0.0004 0.007
Schistosoma mansoni hypothetical protein 0.0425 0.0541 0.8876
Trypanosoma cruzi ribonuclease H1, putative 0.0032 0.0036 0.0114
Echinococcus granulosus ecdysone induced protein 78C 0.0015 0.0013 0.0197
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.022
Echinococcus granulosus mothers against decapentaplegic 5 0.0005 0.0001 0.001
Trichomonas vaginalis D-aminoacylase, putative 0.0025 0.0026 0.185
Brugia malayi nuclear hormone receptor 0.0007 0.0003 0.0004
Echinococcus granulosus ribonuclease H1 0.0032 0.0036 0.0524
Brugia malayi steroid hormone receptor 0.0015 0.0013 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0015 0.0013 0.0018
Schistosoma mansoni cpg binding protein 0.0015 0.0013 0.0221
Brugia malayi orphan nuclear receptor NR2E1 0.0007 0.0003 0.0004
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0025 0.0026 0.1102
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0008 0.0004 0.007
Mycobacterium tuberculosis Conserved protein 0.0025 0.0026 0.1102
Onchocerca volvulus Ribonuclease H1 homolog 0.0032 0.0036 0.0036
Schistosoma mansoni thyroid hormone receptor 0.0015 0.0013 0.022
Loa Loa (eye worm) hypothetical protein 0.0008 0.0005 0.0077
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0005 0.0001 0.001
Brugia malayi beta-lactamase 0.0025 0.0026 0.0036
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0013 0.001 0.0153
Brugia malayi intermediate filament protein 0.0017 0.0016 0.0022
Brugia malayi nuclear receptor RXR 0.0008 0.0004 0.0006
Echinococcus granulosus TGF beta signal transducer SmadC 0.0005 0.0001 0.001
Brugia malayi beta-lactamase family protein 0.0025 0.0026 0.0036
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0045 0.0052 0.0853
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0478 0.0609 0.0609
Loa Loa (eye worm) intermediate filament protein 0.0017 0.0016 0.0265
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0013 0.0197
Loa Loa (eye worm) hypothetical protein 0.0008 0.0004 0.007
Loa Loa (eye worm) hypothetical protein 0.0106 0.013 0.2128
Loa Loa (eye worm) hypothetical protein 0.0106 0.013 0.2128
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0008 0.0004 0.0062
Plasmodium vivax telomerase reverse transcriptase, putative 0.2124 0.2726 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0051
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0015 0.0013 0.022
Schistosoma mansoni hypothetical protein 0.0048 0.0056 0.0923
Onchocerca volvulus 0.0013 0.001 0.001
Mycobacterium ulcerans hypothetical protein 0.0025 0.0026 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.022
Mycobacterium tuberculosis Probable oxidoreductase 0.0061 0.0073 0.3469
Schistosoma mansoni phosphoglucomutase 0.0032 0.0036 0.0586
Loa Loa (eye worm) hypothetical protein 0.0025 0.0026 0.0434
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0015 0.0013 0.022
Trichomonas vaginalis esterase, putative 0.0025 0.0026 0.185
Loa Loa (eye worm) hypothetical protein 0.0008 0.0004 0.007
Loa Loa (eye worm) DR-78 0.0007 0.0003 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0015 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0238 0.0299 0.4914
Loa Loa (eye worm) glutathione reductase 0.0024 0.0025 0.0412
Plasmodium vivax ataxin-2 like protein, putative 0.0013 0.001 0.0021
Trypanosoma brucei unspecified product 0.0035 0.0039 0.0127
Brugia malayi MH1 domain containing protein 0.0005 0.0001 0.0001
Echinococcus granulosus intermediate filament protein 0.0017 0.0016 0.0237
Onchocerca volvulus 0.0048 0.0056 0.0056
Mycobacterium tuberculosis Probable lipase LipE 0.0025 0.0026 0.1102
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0015 0.0013 0.022
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0015 0.0013 0.0197
Leishmania major telomerase reverse transcriptase, putative 0.2124 0.2726 1
Toxoplasma gondii ABC1 family protein 0.0025 0.0026 0.008
Toxoplasma gondii RNA-directed DNA polymerase 0.2124 0.2726 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0025 0.0026 1
Onchocerca volvulus 0.0007 0.0003 0.0003
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0007 0.0003 0.0046
Brugia malayi hypothetical protein 0.0007 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0008 0.0004 0.007
Echinococcus multilocularis musashi 0.0017 0.0016 0.0237
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0056 0.0077
Schistosoma mansoni steroid hormone receptor ad4bp 0.0015 0.0013 0.022
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0051
Echinococcus granulosus smad 0.0005 0.0001 0.001
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0051
Brugia malayi CXXC zinc finger family protein 0.0014 0.0012 0.0017
Onchocerca volvulus Bile acid receptor homolog 0.0015 0.0013 0.0013
Echinococcus multilocularis cpg binding protein 0.0015 0.0013 0.0197
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0015 0.0013 0.0018
Echinococcus multilocularis protection of telomeres protein 1 0.0535 0.0681 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0015 0.0013 0.022
Trypanosoma brucei ingi protein (ORF1) 0.0035 0.0039 0.0127
Echinococcus granulosus Nuclear hormone receptor HR96 0.0007 0.0003 0.0046
Toxoplasma gondii thioredoxin reductase 0.0024 0.0025 0.0075
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0015 0.0013 0.0197
Toxoplasma gondii LsmAD domain-containing protein 0.0013 0.001 0.0021
Schistosoma mansoni smad1 5 8 and 0.0005 0.0001 0.0011
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0015 0.0013 0.0197
Brugia malayi nuclear hormone receptor 0.0015 0.0013 0.0018
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0478 0.0609 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.022
Schistosoma mansoni cpg binding protein 0.0014 0.0012 0.0203
Leishmania major ribonuclease H1, putative 0.0032 0.0036 0.0114
Trypanosoma cruzi ribonuclease H1, putative 0.0032 0.0036 0.0114
Loa Loa (eye worm) histone methyltransferase 0.0005 0 0.0004
Schistosoma mansoni intermediate filament proteins 0.0017 0.0016 0.0265
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0055 0.0065 0.3066
Brugia malayi Thioredoxin reductase 0.0024 0.0025 0.0035
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0161 0.0201 1
Mycobacterium ulcerans beta-lactamase 0.0025 0.0026 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0007 0.0003 0.0046
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0051
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0015 0.0013 0.0197
Brugia malayi nuclear receptor RXR 0.0007 0.0003 0.0004
Mycobacterium tuberculosis Probable reductase 0.0055 0.0065 0.3066
Loa Loa (eye worm) hypothetical protein 0.0025 0.0026 0.0434
Brugia malayi RNase H family protein 0.0032 0.0036 0.0049
Schistosoma mansoni nuclear receptor nhr-48 0.0007 0.0003 0.0051
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.2124 0.2726 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0008 0.0005 0.007
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0006 0.0002 0.0003
Echinococcus granulosus geminin 0.0109 0.0134 0.1959
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0015 0.0013 0.022
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0008 0.0005 0.007
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0007 0.0003 0.0046
Schistosoma mansoni hypothetical protein 0.0006 0.0001 0.0021
Schistosoma mansoni cpg binding protein 0.0015 0.0013 0.0221
Brugia malayi hypothetical protein 0.0013 0.001 0.0014
Brugia malayi ecdysone receptor 0.0007 0.0003 0.0004
Plasmodium vivax SET domain protein, putative 0.0013 0.001 0.0021
Brugia malayi RNase H family protein 0.0032 0.0036 0.0049
Echinococcus multilocularis nuclear receptor nhr 48 0.0007 0.0003 0.0046
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0015 0.0013 0.022
Brugia malayi RNase H family protein 0.0032 0.0036 0.0049
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0013 0.0018
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0006 0.0001 0.0019
Mycobacterium ulcerans lipase LipD 0.0025 0.0026 1
Schistosoma mansoni thyroid hormone receptor 0.0015 0.0013 0.022
Schistosoma mansoni smad1 5 8 and 0.0005 0.0001 0.0011
Loa Loa (eye worm) hypothetical protein 0.0025 0.0026 0.0434
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0008 0.0005 0.0069
Mycobacterium tuberculosis Conserved protein 0.0025 0.0026 0.1102
Onchocerca volvulus 0.0025 0.0026 0.0026
Schistosoma mansoni phosphoglucomutase 0.0032 0.0036 0.0586
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.022
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0035 0.0039 0.0127
Brugia malayi hypothetical protein 0.0008 0.0005 0.0006
Trichomonas vaginalis ribonuclease H1, putative 0.0032 0.0036 0.2646
Loa Loa (eye worm) transcription factor SMAD2 0.0076 0.0092 0.1514
Onchocerca volvulus 0.0025 0.0026 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0015 0.0013 0.0018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0013 0.001 0.0171
Onchocerca volvulus 0.0099 0.0122 0.0122
Mycobacterium tuberculosis Probable dehydrogenase 0.0055 0.0065 0.3066
Trichomonas vaginalis set domain proteins, putative 0.0099 0.0122 1
Onchocerca volvulus 0.0015 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0025 0.0026 0.0434
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0015 0.0013 0.0018
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0013 0.0197
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0012 0.0009 0.0138
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0006 0.0001 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0015 0.0013 0.0018
Brugia malayi Intermediate filament tail domain containing protein 0.0017 0.0016 0.0022
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0051
Echinococcus multilocularis thioredoxin glutathione reductase 0.0025 0.0026 0.0375
Schistosoma mansoni serine/threonine protein kinase 0.0478 0.0609 1
Schistosoma mansoni hypothetical protein 0.0109 0.0134 0.2191
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0055 0.0065 0.3066
Mycobacterium tuberculosis Probable hydrolase 0.0025 0.0026 0.1102
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0039 0.0127
Trichomonas vaginalis penicillin-binding protein, putative 0.0025 0.0026 0.185
Brugia malayi MH2 domain containing protein 0.0005 0.0001 0.0001
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0087 0.0106 0.1745
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0015 0.0013 0.0197
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0013 0.001 0.0171
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0025 0.0026 0.0036
Mycobacterium tuberculosis Conserved protein 0.0025 0.0026 0.1102
Brugia malayi hypothetical protein 0.0008 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.022
Echinococcus granulosus cpg binding protein 0.0015 0.0013 0.0197
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0015 0.0013 0.022
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0015 0.0013 0.0018
Brugia malayi nuclear receptor NHR-88 0.0015 0.0013 0.0018
Brugia malayi Telomerase reverse transcriptase 0.5653 0.7264 1
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0032 0.0036 1
Toxoplasma gondii ribonuclease HI protein 0.0032 0.0036 0.0114
Schistosoma mansoni RAR-like nuclear receptor 0.0015 0.0013 0.022
Plasmodium falciparum telomerase reverse transcriptase 0.2124 0.2726 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0051
Loa Loa (eye worm) hypothetical protein 0.0008 0.0004 0.007
Brugia malayi nuclear hormone receptor family member odr-7 0.0007 0.0003 0.0004
Trypanosoma cruzi PAB1-binding protein , putative 0.0013 0.001 0.0021
Loa Loa (eye worm) thioredoxin reductase 0.0024 0.0025 0.0412
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0008 0.0005 0.0078
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0026 0.008
Plasmodium falciparum thioredoxin reductase 0.0024 0.0025 0.0075
Schistosoma mansoni Smad4 0.0005 0.0001 0.0011
Onchocerca volvulus 0.0017 0.0016 0.0016
Plasmodium falciparum glutathione reductase 0.0024 0.0025 0.0075
Onchocerca volvulus 0.0014 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0008 0.0004 0.007
Brugia malayi beta-lactamase family protein 0.0025 0.0026 0.0036
Echinococcus multilocularis ecdysone induced protein 78C 0.0015 0.0013 0.0197
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0024 0.0025 0.1036
Brugia malayi glutathione reductase 0.0024 0.0025 0.0035
Brugia malayi Protein kinase domain containing protein 0.0478 0.0609 0.0839
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0055 0.0065 0.8296
Echinococcus multilocularis ribonuclease H1 0.0032 0.0036 0.0524
Echinococcus granulosus FTZ F1 alpha 0.0015 0.0013 0.0197
Schistosoma mansoni hypothetical protein 0.0204 0.0257 0.421
Brugia malayi conserved hypotetical protein 0.0007 0.0003 0.0004
Loa Loa (eye worm) nuclear hormone receptor 0.0007 0.0003 0.0051
Brugia malayi photoreceptor-specific nuclear receptor 0.0015 0.0013 0.0018

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.000000914 M Inhibition of [125I]-eotaxin-1 binding to human chemokine receptor (hCCR3-C1) ChEMBL. 15743194
Ki (binding) = 0.000000914 M Inhibition of [125I]-eotaxin-1 binding to human chemokine receptor (hCCR3-C1) ChEMBL. 15743194

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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