Detailed information for compound 368287

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 515.908 | Formula: C27H21ClF3NO4
  • H donors: 0 H acceptors: 0 LogP: 6.64 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc2c(c1OC)c[n+]1c(c2Cc2cc(F)c(c(c2)F)F)c2cc3OCOc3cc2CC1.[Cl-]
  • InChi: 1S/C27H21F3NO4.ClH/c1-32-22-4-3-16-18(7-14-8-20(28)25(30)21(29)9-14)26-17-11-24-23(34-13-35-24)10-15(17)5-6-31(26)12-19(16)27(22)33-2;/h3-4,8-12H,5-7,13H2,1-2H3;1H/q+1;/p-1
  • InChiKey: DVXFVPKLAYEFQL-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0025 0.0491 0.2322
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0581 0.2666
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0011 0.0037 0.0176
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0011 0.0037 0.0041
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0076 0.2113 0.2345
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0025 0.0491 0.0545
Echinococcus multilocularis solute carrier family 22 0.0011 0.0024 0.0026
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0028 0.0581 0.2748
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0397 0.1786
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0214 0.0909
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0076 0.2113 0.2345
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0028 0.0581 0.0644
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0436 0.1973
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0014 0.0143 1
Plasmodium falciparum calcium-dependent protein kinase 4 0.0023 0.0427 0.0404
Schistosoma mansoni nephrin 0.0025 0.0491 0.2322
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0135 0.015
Schistosoma mansoni septate junction protein 0.0014 0.0135 0.0641
Schistosoma mansoni titin 0.0011 0.0037 0.0176
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0166 0.0684
Brugia malayi Fibronectin type III domain containing protein 0.0044 0.1073 0.5079
Echinococcus granulosus defective proboscis extension response 0.0044 0.1073 0.1191
Brugia malayi Major Facilitator Superfamily protein 0.0011 0.0024 0.0112
Brugia malayi lysyl-tRNA synthetase 0.0017 0.0224 0.1062
Brugia malayi Animal haem peroxidase family protein 0.0011 0.0037 0.0176
Onchocerca volvulus Peroxidasin homolog 0.0011 0.0037 0.0266
Echinococcus granulosus neuroglian 0.0025 0.0491 0.0545
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0112
Echinococcus multilocularis titin 0.0011 0.0037 0.0041
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0023 0.0426 0.0473
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0112
Echinococcus multilocularis titin 0.0011 0.0037 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0167 0.0687
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0025 0.0491 0.2322
Loa Loa (eye worm) phosphatidylinositol 3 0.0028 0.0581 0.2748
Schistosoma mansoni hypothetical protein 0.0011 0.0037 0.0176
Loa Loa (eye worm) hypothetical protein 0.0044 0.1073 0.5079
Brugia malayi Immunoglobulin I-set domain containing protein 0.0011 0.0037 0.0176
Schistosoma mansoni sugar transporter 0.0011 0.0024 0.0112
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0397 0.1786
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0023 0.0427 0.0617
Plasmodium falciparum calcium-dependent protein kinase 1 0.0023 0.0427 0.0404
Echinococcus multilocularis roundabout 2 0.0069 0.1882 0.2089
Brugia malayi Immunoglobulin I-set domain containing protein 0.0011 0.0037 0.0176
Schistosoma mansoni hypothetical protein 0.0011 0.0037 0.0176
Echinococcus granulosus Sugar transporter ERD6 protein 0.0011 0.0024 0.0026
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0025 0.0491 0.2322
Echinococcus multilocularis titin 0.0013 0.0084 0.0093
Schistosoma mansoni glucose transport protein 0.0076 0.2113 1
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.024 0.1034
Plasmodium falciparum calcium-dependent protein kinase 3 0.0023 0.0427 0.0404
Echinococcus granulosus Immunoglobulin 0.0014 0.0135 0.015
Schistosoma mansoni titin 0.0011 0.0037 0.0176
Toxoplasma gondii protein kinase, putative 0.0216 0.655 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0411 0.1946
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.0176
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0112
Brugia malayi Immunoglobulin domain containing protein 0.0014 0.0135 0.0641
Echinococcus multilocularis Immunoglobulin 0.0014 0.0135 0.015
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0491 0.2322
Entamoeba histolytica protein kinase, putative 0.0023 0.0426 0.5664
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.0014 0.0135 0.015
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0112
Loa Loa (eye worm) hypothetical protein 0.0025 0.047 0.2223
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0135 0.0641
Loa Loa (eye worm) TK protein kinase 0.0015 0.0164 0.0774
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0028 0.0581 0.0644
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0027 0.0532 0.0779
Echinococcus multilocularis Immunoglobulin 0.0044 0.1073 0.1191
Echinococcus multilocularis down syndrome cell adhesion 0.0011 0.0037 0.0041
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0084 0.0396
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0397 0.1786
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0581 0.2666
Echinococcus granulosus twitchin 0.0056 0.1475 0.1637
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0014 0.0135 0.0641
Plasmodium vivax calcium-dependent protein kinase, putative 0.0023 0.0427 0.0404
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0112
Echinococcus granulosus solute carrier family 22 0.0011 0.0024 0.0026
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0135 0.0641
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0491 0.2322
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0076 0.2113 0.2345
Schistosoma mansoni lysyl-tRNA synthetase 0.0017 0.0224 0.1062
Brugia malayi Immunoglobulin I-set domain containing protein 0.0011 0.0037 0.0176
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0167 0.0687
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0025 0.0491 0.0545
Brugia malayi Immunoglobulin I-set domain containing protein 0.0062 0.1653 0.7824
Echinococcus granulosus insulin growth factor binding 0.0011 0.0037 0.0041
Schistosoma mansoni basigin related 0.0014 0.0135 0.0641
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0014 0.0135 0.0641
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0491 0.2322
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0011 0.0037 0.0176
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0017 0.0224 0.0961
Plasmodium vivax proline--tRNA ligase, putative 0.0027 0.0532 0.051
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0011 0.0037 0.0176
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.0176
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0023 0.0426 0.0473
Schistosoma mansoni titin 0.0013 0.0084 0.0396
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0023 0.0411 0.1855
Echinococcus multilocularis peroxidasin 0.0025 0.0491 0.0545
Toxoplasma gondii facilitative glucose transporter GT1 0.0076 0.2113 0.3201
Onchocerca volvulus 0.0011 0.0037 0.0266
Echinococcus multilocularis roundabout 2 0.0025 0.0491 0.0545
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.0176
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0491 0.2322
Leishmania major glucose transporter, lmgt3 0.0024 0.0436 0.7398
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0011 0.0037 0.0176
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0112
Loa Loa (eye worm) hypothetical protein 0.0014 0.0135 0.0641
Echinococcus granulosus peroxidasin 0.0025 0.0491 0.0545
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0076 0.2113 0.2345
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0219 0.0935
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0032 0.0687 0.3254
Loa Loa (eye worm) hypothetical protein 0.0069 0.1882 0.8907
Echinococcus granulosus neuropeptide receptor A26 0.0293 0.9011 1
Brugia malayi Sugar transporter family protein 0.0011 0.0024 0.0112
Loa Loa (eye worm) hypothetical protein 0.0022 0.0369 0.1748
Trypanosoma brucei glucose transporter, putative 0.0024 0.0436 0.7398
Brugia malayi Disorganized muscle protein 1 0.0011 0.0037 0.0176
Schistosoma mansoni cell adhesion molecule 0.0058 0.1527 0.7225
Schistosoma mansoni slit 0.0011 0.0037 0.0176
Schistosoma mansoni titin 0.0011 0.0037 0.0176
Leishmania major lysyl-tRNA synthetase, putative 0.0017 0.0224 0.3605
Trypanosoma brucei glucose transporter, putative 0.0024 0.0436 0.7398
Schistosoma mansoni hypothetical protein 0.0014 0.0135 0.0641
Schistosoma mansoni sugar transporter 0.0011 0.0024 0.0112
Brugia malayi Heparan sulfate 0.0014 0.0135 0.0641
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.0176
Echinococcus granulosus leucine rich repeat containing protein 4 0.0011 0.0037 0.0041
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0011 0.0024 0.5
Schistosoma mansoni roundabout 0.0025 0.0491 0.2322
Brugia malayi Immunoglobulin I-set domain containing protein 0.0011 0.0037 0.0176
Plasmodium vivax lysine--tRNA ligase, putative 0.0017 0.0224 0.0201
Brugia malayi Myb-like DNA-binding domain containing protein 0.0011 0.0037 0.0176
Trichomonas vaginalis glucose transporter, putative 0.0024 0.0436 0.1973
Schistosoma mansoni hypothetical protein 0.0014 0.0135 0.0641
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0011 0.0037 0.0176
Brugia malayi latrophilin 2 splice variant baaae 0.0022 0.0369 0.1748
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0426 0.2017
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0014 0.0135 0.015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0166 0.0684
Echinococcus multilocularis solute carrier family 22 0.0011 0.0024 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.035 0.1564
Trypanosoma brucei glucose transporter, putative 0.0024 0.0436 0.7398
Echinococcus granulosus chromobox protein 1 0.0044 0.1087 0.1207
Toxoplasma gondii target of rapamycin (TOR), putative 0.0021 0.035 0.0501
Loa Loa (eye worm) hypothetical protein 0.0025 0.0491 0.2322
Schistosoma mansoni basigin related 0.0014 0.0135 0.0641
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0027 0.0532 0.9126
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0265 0.1157
Giardia lamblia Prolyl-tRNA synthetase 0.0023 0.0411 0.6956
Brugia malayi Major Facilitator Superfamily protein 0.0011 0.0024 0.0112
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.0176
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0023 0.0411 0.1946
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0023 0.0427 0.0404
Echinococcus granulosus leucine rich repeats and immunoglobulin 0.0011 0.0037 0.0041
Loa Loa (eye worm) one IG domain family member 0.0011 0.0037 0.0176
Onchocerca volvulus Tyrosine kinase homolog 0.0015 0.0164 0.2765
Brugia malayi Immunoglobulin I-set domain containing protein 0.0011 0.0037 0.0176
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0491 0.2322
Echinococcus granulosus pro neuregulin 2 membrane bound 0.0011 0.0037 0.0041
Schistosoma mansoni glucose transport protein 0.0076 0.2113 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0028 0.0581 1
Schistosoma mansoni protein kinase 0.0023 0.0426 0.2017
Echinococcus granulosus calcium dependent protein kinase 0.0022 0.038 0.0422
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0135 0.0641
Trypanosoma brucei THT1 - hexose transporter, putative 0.0024 0.0436 0.7398
Echinococcus granulosus neuroglian 0.0055 0.1428 0.1585
Brugia malayi Calcitonin receptor-like protein seb-1 0.0032 0.0687 0.3254
Schistosoma mansoni cell adhesion molecule 0.0025 0.0491 0.2322
Echinococcus granulosus roundabout 2 0.0025 0.0491 0.0545
Schistosoma mansoni netrin receptor unc5 0.0014 0.0135 0.0641
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0011 0.0024 0.0112
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0135 0.0641
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0112
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0025 0.0491 0.0545
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0062 0.1653 0.7824
Echinococcus granulosus lysyl tRNA synthetase 0.0017 0.0224 0.0249
Echinococcus granulosus down syndrome cell adhesion 0.0011 0.0037 0.0041
Schistosoma mansoni hypothetical protein 0.0011 0.0037 0.0176
Echinococcus multilocularis Immunoglobulin 0.0044 0.1073 0.1191
Trichomonas vaginalis glucose transporter, putative 0.0024 0.0436 0.1973
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0023 0.0426 0.2017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.035 0.1564
Schistosoma mansoni chromobox protein 0.0044 0.1087 0.5146
Brugia malayi Immunoglobulin I-set domain containing protein 0.0011 0.0037 0.0176
Schistosoma mansoni cell adhesion molecule 0.0011 0.0037 0.0176
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0017 0.0224 1
Trypanosoma brucei glucose transporter, putative 0.0024 0.0436 0.7398
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.035 0.1564
Trichomonas vaginalis sugar transporter, putative 0.0024 0.0436 0.1973
Brugia malayi chromobox protein homolog 3 0.0025 0.047 0.2223
Brugia malayi Immunoglobulin domain containing protein 0.0014 0.0135 0.0641
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0023 0.0427 0.0617
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0028 0.0581 1
Schistosoma mansoni hypothetical protein 0.0011 0.0037 0.0176
Loa Loa (eye worm) heterochromatin protein 1 0.0044 0.1087 0.5146
Plasmodium falciparum hexose transporter 0.0076 0.2113 0.2094
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0135 0.015
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0014 0.0135 0.0641
Brugia malayi Prion-like- 0.0025 0.0491 0.2322
Loa Loa (eye worm) hypothetical protein 0.0044 0.1073 0.5079
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0025 0.0491 0.2322
Loa Loa (eye worm) LAD-2 short isoform 0.0014 0.0135 0.0641
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0167 0.0687
Schistosoma mansoni septate junction protein 0.0014 0.0135 0.0641
Leishmania major glucose transporter/membrane transporter D2, putative 0.0024 0.0436 0.7398
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0017 0.0224 0.3605
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0022 0.0398 0.6712
Onchocerca volvulus Putative titin 0.0011 0.0037 0.0266
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0397 0.1786
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.0176
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0044 0.1073 0.5079
Plasmodium falciparum protein kinase 7 0.0216 0.655 0.6542
Loa Loa (eye worm) hypothetical protein 0.0014 0.0135 0.0641
Echinococcus granulosus titin 0.0011 0.0037 0.0041
Echinococcus granulosus low density lipoprotein receptor ldl 0.0014 0.0135 0.015
Trichomonas vaginalis chromobox protein, putative 0.0027 0.053 0.2421
Trypanosoma cruzi hexose transporter, putative 0.0013 0.0094 0.1262
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0027 0.053 1
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0014 0.0135 0.015
Onchocerca volvulus 0.0011 0.0037 0.0266
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.047 0.2135
Schistosoma mansoni hypothetical protein 0.0011 0.0037 0.0176
Loa Loa (eye worm) hypothetical protein 0.0069 0.1882 0.8907
Echinococcus multilocularis chromobox protein 1 0.0044 0.1087 0.1207
Brugia malayi hypothetical protein 0.0011 0.0024 0.0112
Loa Loa (eye worm) hypothetical protein 0.0014 0.0135 0.0641
Echinococcus multilocularis hemicentin 1 0.0025 0.0491 0.0545
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0023 0.0411 0.1946
Echinococcus granulosus roundabout 2 0.0069 0.1882 0.2089
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0028 0.0581 1
Schistosoma mansoni netrin receptor unc5 0.0014 0.0135 0.0641
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0076 0.2113 0.2345
Brugia malayi Immunoglobulin I-set domain containing protein 0.0044 0.1073 0.5079
Echinococcus multilocularis Immunoglobulin subtype 0.0014 0.0135 0.015
Trichomonas vaginalis chromobox protein, putative 0.0044 0.1087 0.5091
Echinococcus granulosus solute carrier family 22 0.0011 0.0024 0.0026
Loa Loa (eye worm) hypothetical protein 0.0025 0.0491 0.2322
Echinococcus granulosus lachesin 0.0025 0.0491 0.0545
Schistosoma mansoni nephrin related 0.0011 0.0037 0.0176
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.0176
Schistosoma mansoni hypothetical protein 0.0014 0.0135 0.0641
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.035 0.1564
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0058 0.1527 0.1694
Trypanosoma brucei THT1 - hexose transporter, putative 0.0024 0.0436 0.7398
Echinococcus granulosus pro neuregulin 2 membrane bound 0.0014 0.0135 0.015
Onchocerca volvulus 0.0019 0.0299 0.5453
Echinococcus multilocularis chromobox protein 1 0.0044 0.1087 0.1207
Echinococcus multilocularis neuropeptide receptor A26 0.0293 0.9011 1
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0123 0.361 0.5495
Brugia malayi Heterochromatin protein 1 0.0044 0.1087 0.5146
Schistosoma mansoni titin 0.0011 0.0037 0.0176
Loa Loa (eye worm) hypothetical protein 0.0044 0.1073 0.5079
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0023 0.0426 0.0473
Brugia malayi basement membrane proteoglycan 0.0014 0.0135 0.0641
Brugia malayi major facilitator superfamily protein 0.0011 0.0024 0.0112
Onchocerca volvulus 0.0011 0.0037 0.0266
Loa Loa (eye worm) hypothetical protein 0.0032 0.0687 0.3254
Schistosoma mansoni protein kinase 0.0023 0.0426 0.2017
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0491 0.2322
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.0176
Giardia lamblia GTOR 0.0028 0.0581 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.0176
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0023 0.0426 0.0473
Trypanosoma brucei glucose transporter, putative 0.0024 0.0436 0.7398
Trichomonas vaginalis chromobox protein, putative 0.0044 0.1087 0.5091
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0023 0.0411 0.1946
Echinococcus multilocularis tyrosine protein kinase otk 0.0025 0.0491 0.0545
Schistosoma mansoni myosin-binding protein-related 0.0011 0.0037 0.0176
Schistosoma mansoni hypothetical protein 0.0011 0.0037 0.0176
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.0176
Onchocerca volvulus 0.0011 0.0037 0.0266
Loa Loa (eye worm) hypothetical protein 0.0025 0.0491 0.2322
Brugia malayi Wrapper/rega-1/klingon homolog protein 1 0.0011 0.0037 0.0176
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0028 0.0581 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0015 0.0164 0.0774
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0436 0.1973
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0023 0.0426 0.0473
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0027 0.0537 0.2542
Onchocerca volvulus 0.0011 0.0037 0.0266
Brugia malayi Immunoglobulin I-set domain containing protein 0.0011 0.0037 0.0176
Onchocerca volvulus 0.0011 0.0037 0.0266
Trichomonas vaginalis sugar transporter, putative 0.0024 0.0436 0.1973
Trypanosoma cruzi hexose transporter, putative 0.0024 0.0436 0.7398
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0219 0.0935
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0023 0.0426 0.0473
Schistosoma mansoni basigin related 0.0014 0.0135 0.0641
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0135 0.0641
Plasmodium falciparum calcium-dependent protein kinase 2 0.0023 0.0427 0.0404
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.0176
Echinococcus multilocularis Opioid binding protein:cell adhesion molecule 0.0011 0.0037 0.0041
Echinococcus granulosus tyrosine protein kinase otk 0.0025 0.0491 0.0545
Trypanosoma brucei glucose transporter, putative 0.0024 0.0436 0.7398
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0044 0.1073 0.5079
Trichomonas vaginalis sugar transporter, putative 0.0024 0.0436 0.1973
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0025 0.0491 0.0545
Brugia malayi Immunoglobulin I-set domain containing protein 0.0013 0.0084 0.0396
Loa Loa (eye worm) hypothetical protein 0.0023 0.0411 0.1946
Echinococcus granulosus Immunoglobulin 0.0044 0.1073 0.1191
Trypanosoma brucei glucose transporter 1E 0.0024 0.0436 0.7398
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0112
Schistosoma mansoni protein kinase 0.0023 0.0426 0.2017
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.2113 1
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0023 0.0411 0.0456
Schistosoma mansoni lysyl-tRNA synthetase 0.0017 0.0224 0.1062
Loa Loa (eye worm) sugar transporter 0.0076 0.2113 1
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0023 0.0426 0.2017
Onchocerca volvulus Netrin receptor homolog 0.0011 0.0037 0.0266
Echinococcus multilocularis solute carrier family 22 0.0011 0.0024 0.0026
Plasmodium vivax CDK-related protein kinase 6, putative 0.0324 1 1
Echinococcus granulosus titin 0.0011 0.0037 0.0041
Trypanosoma brucei glucose transporter 2A 0.0024 0.0436 0.7398
Schistosoma mansoni titin 0.0011 0.0037 0.0176
Echinococcus multilocularis lachesin 0.0025 0.0491 0.0545
Echinococcus granulosus Immunoglobulin subtype 0.0014 0.0135 0.015
Schistosoma mansoni titin 0.0011 0.0037 0.0176
Loa Loa (eye worm) hypothetical protein 0.0019 0.0299 0.1417
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0014 0.0135 0.015
Schistosoma mansoni hypothetical protein 0.0022 0.0369 0.1748
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0022 0.0398 0.6712
Schistosoma mansoni sugar transporter 0.0011 0.0024 0.0112
Echinococcus multilocularis hemicentin 1 0.0025 0.0491 0.0545
Brugia malayi Immunoglobulin I-set domain containing protein 0.0011 0.0037 0.0176
Trichomonas vaginalis CAMK family protein kinase 0.0023 0.0426 0.1927
Brugia malayi Cam kinase protein 1 0.0023 0.0426 0.2017
Echinococcus granulosus 3'partial|cell adhesion molecule:down regulated by 0.0014 0.0135 0.015
Loa Loa (eye worm) hypothetical protein 0.0025 0.0491 0.2322
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0135 0.0641
Echinococcus multilocularis synaptic vesicle 2 protein 0.0011 0.0024 0.0026
Trypanosoma cruzi hexose transporter, putative 0.0024 0.0436 0.7398
Echinococcus multilocularis leucine rich repeat containing protein 4 0.0014 0.0135 0.015
Plasmodium vivax hexose transporter 0.0076 0.2113 0.2094
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.0176
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0023 0.0411 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0112
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0028 0.0581 1
Brugia malayi hypothetical protein 0.0014 0.0135 0.0641
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0017 0.0224 0.3046
Plasmodium falciparum calcium-dependent protein kinase 5 0.0023 0.0427 0.0404
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.0176
Echinococcus granulosus chromobox protein 1 0.0044 0.1087 0.1207
Echinococcus multilocularis neuropeptide s receptor 0.0293 0.9011 1
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0084 0.0396
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0032 0.0687 0.3254
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.0176
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0449 0.2037
Echinococcus granulosus contactin 0.0025 0.0491 0.0545
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.035 0.1564
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.0176
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0028 0.0581 1
Brugia malayi Sugar transporter family protein 0.0011 0.0024 0.0112
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0017 0.0224 0.3605
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0017 0.0224 1
Echinococcus granulosus synaptic vesicle 2 protein 0.0011 0.0024 0.0026
Schistosoma mansoni nephrin related 0.0014 0.0135 0.0641
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0112
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0014 0.0135 0.015
Loa Loa (eye worm) hypothetical protein 0.0058 0.1527 0.7225
Loa Loa (eye worm) hypothetical protein 0.0044 0.1073 0.5079
Brugia malayi Major Facilitator Superfamily protein 0.0011 0.0024 0.0112
Onchocerca volvulus Peroxidasin homolog 0.0011 0.0037 0.0266
Schistosoma mansoni septate junction protein 0.0025 0.0491 0.2322
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.024 0.1034
Echinococcus granulosus General substrate transporter 0.0066 0.1771 0.1965
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0014 0.0135 0.0641
Echinococcus multilocularis roundabout 2 0.0025 0.0491 0.0545
Brugia malayi kettin 0.0011 0.0037 0.0176
Echinococcus granulosus titin 0.0013 0.0084 0.0093
Trypanosoma brucei glucose transporter, putative 0.0024 0.0436 0.7398
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0112
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0166 0.0684
Echinococcus multilocularis titin 0.0011 0.0037 0.0041
Onchocerca volvulus 0.0013 0.0084 0.1185
Loa Loa (eye worm) sugar transporter 0.0011 0.0024 0.0112
Echinococcus granulosus Immunoglobulin 0.0014 0.0135 0.015
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0023 0.0426 0.0473
Brugia malayi protein unc-22 0.0013 0.0084 0.0396
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0164 0.0774
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.0176
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0023 0.0426 0.0473
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0025 0.0491 0.0545
Plasmodium falciparum mitogen-activated protein kinase 2 0.0123 0.361 0.3595
Brugia malayi Peroxidasin 0.0025 0.0491 0.2322
Trypanosoma brucei glucose transporter, putative 0.0024 0.0436 0.7398
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0167 0.0687
Echinococcus granulosus neuropeptide s receptor 0.0293 0.9011 1
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0027 0.0532 0.9126
Loa Loa (eye worm) major facilitator superfamily transporter 0.0011 0.0024 0.0112
Schistosoma mansoni hypothetical protein 0.0014 0.0135 0.0641
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0014 0.0143 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0028 0.0581 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0025 0.0491 0.0545
Echinococcus granulosus nephrin 0.0011 0.0037 0.0041
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0112
Brugia malayi Prion-like- 0.0011 0.0037 0.0176
Echinococcus multilocularis Immunoglobulin 0.0014 0.0135 0.015
Schistosoma mansoni cell adhesion molecule 0.0011 0.0037 0.0176
Schistosoma mansoni tyrosine kinase 0.0029 0.0617 0.2921
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0012 0.0055 0.0566
Loa Loa (eye worm) major facilitator superfamily transporter 0.0011 0.0024 0.0112
Brugia malayi Immunoglobulin I-set domain containing protein 0.0011 0.0037 0.0176
Loa Loa (eye worm) hypothetical protein 0.0025 0.0491 0.2322
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0025 0.0491 0.2322
Brugia malayi Immunoglobulin I-set domain containing protein 0.0011 0.0037 0.0176
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0027 0.0532 0.9126
Onchocerca volvulus 0.0011 0.0037 0.0266
Brugia malayi Immunoglobulin I-set domain containing protein 0.0011 0.0037 0.0176
Echinococcus granulosus roundabout 2 0.0025 0.0491 0.0545
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0025 0.047 0.8817
Echinococcus multilocularis leucine rich repeats and immunoglobulin 0.0011 0.0037 0.0041
Brugia malayi Immunoglobulin I-set domain containing protein 0.0011 0.0037 0.0176
Brugia malayi basement membrane proteoglycan precursor 0.0014 0.0135 0.0641
Schistosoma mansoni septate junction protein 0.0025 0.0491 0.2322
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0025 0.0491 0.9232
Loa Loa (eye worm) hypothetical protein 0.0044 0.1073 0.5079
Brugia malayi major facilitator superfamily protein 0.0011 0.0024 0.0112
Echinococcus multilocularis cell adhesion molecule:down regulated by 0.0014 0.0135 0.015
Onchocerca volvulus 0.0011 0.0037 0.0266
Echinococcus granulosus titin 0.0011 0.0037 0.0041
Echinococcus multilocularis insulin growth factor binding 0.0011 0.0037 0.0041
Loa Loa (eye worm) projectin 0.0011 0.0037 0.0176
Brugia malayi Leucine Rich Repeat family protein 0.0011 0.0037 0.0176
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0011 0.0024 0.0026
Trypanosoma cruzi hexose transporter 0.0024 0.0436 0.7398
Schistosoma mansoni hypothetical protein 0.0011 0.0037 0.0176
Onchocerca volvulus 0.0011 0.0037 0.0266
Echinococcus multilocularis neuroglian 0.0025 0.0491 0.0545
Loa Loa (eye worm) hypothetical protein 0.0023 0.0426 0.2017
Loa Loa (eye worm) hypothetical protein 0.0025 0.0491 0.2322
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0015 0.0164 0.0181
Trichomonas vaginalis chromobox protein, putative 0.0027 0.053 0.2421
Loa Loa (eye worm) animal heme peroxidase 0.0011 0.0037 0.0176
Brugia malayi hypothetical protein 0.0011 0.0024 0.0112
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0023 0.0426 0.2017
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0028 0.0581 1
Chlamydia trachomatis lysine--tRNA ligase 0.0017 0.0224 0.5
Echinococcus granulosus Opioid binding protein:cell adhesion molecule 0.0011 0.0037 0.0041
Echinococcus multilocularis transfer RNA-Phe 0.0011 0.0037 0.0041
Echinococcus multilocularis 0.0011 0.0037 0.0041
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0023 0.0411 0.5241
Schistosoma mansoni cell adhesion molecule 0.0025 0.0491 0.2322
Schistosoma mansoni vesicular amine transporter 0.0044 0.1073 0.5079
Entamoeba histolytica protein kinase, putative 0.0023 0.0426 0.5664
Plasmodium falciparum lysine--tRNA ligase 0.0017 0.0224 0.0201
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0015 0.0158 0.0641
Echinococcus granulosus titin 0.0013 0.0084 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0285 0.125
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0023 0.0427 0.0617
Schistosoma mansoni subfamily M23B non-peptidase homologue (M23 family) 0.0011 0.0037 0.0176
Brugia malayi Immunoglobulin I-set domain containing protein 0.0011 0.0037 0.0176
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.0176
Echinococcus multilocularis lysyl tRNA synthetase 0.0017 0.0224 0.0249
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0023 0.0411 0.0456
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0015 0.0164 0.0181
Brugia malayi Prion-like- 0.0011 0.0037 0.0176
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.035 0.1564
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0491 0.2322
Trypanosoma cruzi target of rapamycin kinase 3 0.0022 0.0398 0.6712
Echinococcus granulosus solute carrier family 22 0.0011 0.0024 0.0026
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0112
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0491 0.2322
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0491 0.2322
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0023 0.0426 0.7227
Trypanosoma cruzi hexose transporter, putative 0.0024 0.0436 0.7398
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0044 0.1073 0.1191
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0025 0.0491 0.2322
Loa Loa (eye worm) hypothetical protein 0.0014 0.0135 0.0641
Echinococcus multilocularis neuroglian 0.0055 0.1428 0.1585
Schistosoma mansoni hypothetical protein 0.0076 0.2113 1
Toxoplasma gondii lysine-tRNA ligase 0.0017 0.0224 0.0308
Brugia malayi Sugar transporter family protein 0.0076 0.2113 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0135 0.0641
Echinococcus multilocularis twitchin 0.0013 0.0084 0.0093
Loa Loa (eye worm) CAMK protein kinase 0.0013 0.0084 0.0396
Schistosoma mansoni cell adhesion molecule 0.0025 0.0491 0.2322
Schistosoma mansoni neuroglian 0.0025 0.0491 0.2322
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0214 0.0909
Brugia malayi Prion-like- 0.0011 0.0037 0.0176
Trypanosoma brucei THT1 - hexose transporter, putative 0.0024 0.0436 0.7398
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.035 0.1564
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0027 0.0532 0.9126
Brugia malayi Immunoglobulin I-set domain containing protein 0.0011 0.0037 0.0176
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.047 0.2135
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0112
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0027 0.0532 0.9126
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0028 0.0581 0.2748
Brugia malayi Immunoglobulin I-set domain containing protein 0.0011 0.0037 0.0176
Echinococcus granulosus solute carrier family 22 0.0011 0.0024 0.0026
Leishmania major glucose transporter, lmgt2 0.0024 0.0436 0.7398
Schistosoma mansoni hypothetical protein 0.0014 0.0135 0.0641
Leishmania major protein kinase, putative 0.0023 0.0426 0.7227
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0219 0.0935
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0112
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0013 0.0084 0.0396
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0581 0.2666
Echinococcus multilocularis solute carrier family 22 0.0011 0.0024 0.0026
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0014 0.0135 0.0641
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0011 0.0037 0.0176
Schistosoma mansoni peroxidasin 0.0014 0.0135 0.0641
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0076 0.2113 0.2345
Brugia malayi Immunoglobulin I-set domain containing protein 0.0011 0.0037 0.0176
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0397 0.1786
Echinococcus granulosus basement membrane specific heparan sulfate 0.0014 0.0135 0.015
Echinococcus multilocularis General substrate transporter 0.0066 0.1771 0.1965
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0011 0.0037 0.0176
Giardia lamblia Lysyl-tRNA synthetase 0.0017 0.0224 0.3605
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0023 0.0427 0.0404
Schistosoma mansoni sugar transporter 0.0011 0.0024 0.0112
Leishmania major glucose transporter, lmgt1 0.0024 0.0436 0.7398
Brugia malayi hypothetical protein 0.0011 0.0024 0.0112
Loa Loa (eye worm) hypothetical protein 0.0019 0.0274 0.1299
Schistosoma mansoni glucose transport protein 0.0076 0.2113 1
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0123 0.361 0.3595
Loa Loa (eye worm) hypothetical protein 0.0044 0.1073 0.5079
Schistosoma mansoni cell adhesion molecule 0.0014 0.0135 0.0641
Schistosoma mansoni nephrin 0.0055 0.1428 0.676
Schistosoma mansoni cell adhesion molecule 0.0011 0.0037 0.0176
Schistosoma mansoni hypothetical protein 0.0014 0.0135 0.0641
Schistosoma mansoni cell adhesion molecule 0.0014 0.0135 0.0641
Schistosoma mansoni glucose transporter 0.0011 0.0024 0.0112
Brugia malayi Immunoglobulin domain containing protein 0.0014 0.0135 0.0641
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.0011 0.0037 0.0041
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0023 0.0411 0.1946
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.0176
Loa Loa (eye worm) immunoglobulin domain-containing protein 0.0014 0.0135 0.0641
Brugia malayi hypothetical protein 0.0044 0.1073 0.5079
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0076 0.2113 0.2345
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0023 0.0427 0.0404
Schistosoma mansoni titin 0.0025 0.0491 0.2322
Loa Loa (eye worm) hypothetical protein 0.0017 0.0224 0.1062
Onchocerca volvulus 0.0011 0.0037 0.0266
Loa Loa (eye worm) hypothetical protein 0.0025 0.0491 0.2322
Brugia malayi Immunoglobulin I-set domain containing protein 0.0011 0.0037 0.0176
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0076 0.2113 0.2345
Echinococcus granulosus hemicentin 1 0.0025 0.0491 0.0545
Echinococcus multilocularis calcium dependent protein kinase 0.0022 0.038 0.0422
Brugia malayi Immunoglobulin I-set domain containing protein 0.0011 0.0037 0.0176
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0011 0.0037 0.0176
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0013 0.0107 0.1495
Schistosoma mansoni chromobox protein 0.0044 0.1087 0.5146
Loa Loa (eye worm) disorganized muscle protein 1 0.0011 0.0037 0.0176
Schistosoma mansoni hemicentin 0.0011 0.0037 0.0176
Plasmodium falciparum proline--tRNA ligase 0.0027 0.0532 0.051

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 64 ug ml-1 Antifungal activity against Cryptococcus neoformans ATCC 36556 by broth microdilution method ChEMBL. 16730982
MIC (functional) = 64 ug ml-1 Antifungal activity against Candida krusei ATCC 6258 by broth microdilution method ChEMBL. 16730982
MIC (functional) = 64 ug ml-1 Antifungal activity against Candida tropicalis ATCC 13803 by broth microdilution method ChEMBL. 16730982
MIC (functional) = 64 ug ml-1 Antifungal activity against Cryptococcus neoformans ATCC 36556 by broth microdilution method ChEMBL. 16730982
MIC (functional) > 128 ug ml-1 Antifungal activity against Aspergillus terreus ATCC 46941 by broth microdilution method ChEMBL. 16730982
MIC (functional) > 128 ug ml-1 Antifungal activity against Aspergillus fumigatus ATCC 16424 by broth microdilution method ChEMBL. 16730982
MIC (functional) = 128 ug ml-1 Antifungal activity against Candida lusitaniae ATCC 42720 by broth microdilution method ChEMBL. 16730982
MIC (functional) = 128 ug ml-1 Antifungal activity against Candida albicans ATCC 10231 by broth microdilution method ChEMBL. 16730982
MIC (functional) = 128 ug ml-1 Antifungal activity against Candida albicans ATCC 10231 by broth microdilution method ChEMBL. 16730982

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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