TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 1327.02 | Formula: C50H72I2N16O11
H donors: 13 H acceptors: 11 LogP: -4.16 Rotable bonds: 35
Rule of 5 violations (Lipinski): 4
SMILES: OCC(C(=O)N1CCCC1C(=O)NC(C(=O)NC(C(=O)O)CCCN=C(N)N)Cc1cc(I)c(c(c1)I)N)NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)C1CCCN1C(=O)C1CCCN1C(=O)C(CCCN=C(N)N)N
InChi: 1S/C50H72I2N16O11/c51-29-21-28(22-30(52)40(29)54)24-34(42(72)63-32(48(78)79)12-5-17-60-50(57)58)64-44(74)37-14-7-18-66(37)46(76)35(26-69)65-41(71)33(23-27-9-2-1-3-10-27)62-39(70)25-61-43(73)36-13-6-19-67(36)47(77)38-15-8-20-68(38)45(75)31(53)11-4-16-59-49(55)56/h1-3,9-10,21-22,31-38,69H,4-8,11-20,23-26,53-54H2,(H,61,73)(H,62,70)(H,63,72)(H,64,74)(H,65,71)(H,78,79)(H4,55,56,59)(H4,57,58,60)
InChiKey: KDANGSAIDSRONO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	voltage-gated potassium channel	0.0176	0.1058	0.24
Schistosoma mansoni	hypothetical protein	0.0162	0.0951	0.2157
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.004	0.0061	0.0138
Schistosoma mansoni	neuropeptide F-like receptor	0.0162	0.0951	0.2157
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0088	0.0407	0.1084
Echinococcus granulosus	sex peptide receptor	0.0162	0.0951	0.1047
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0105	0.0538	0.1057
Echinococcus granulosus	sodium and chloride dependent glycine	0.004	0.0061	0.0067
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0096	0.0472	0.0929
Onchocerca volvulus		0.0162	0.0951	0.1771
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0162	0.0951	0.1047
Schistosoma mansoni	eyes absent homolog	0.0102	0.0514	0.1166
Leishmania major	hypothetical protein, conserved	0.0219	0.1368	0.5041
Echinococcus granulosus	neuropeptide receptor A26	0.0162	0.0951	0.1047
Trichomonas vaginalis	set domain proteins, putative	0.0726	0.5086	1
Trypanosoma cruzi	target of rapamycin kinase 3	0.0108	0.0555	0.2252
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0091	0.0436	0.099
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Loa Loa (eye worm)	jmjC domain-containing protein	0.0133	0.0741	0.167
Brugia malayi	hypothetical protein	0.0052	0.0144	0.0325
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0088	0.0412	0.0453
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0091	0.0436	0.099
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0162	0.0951	0.2157
Echinococcus granulosus	neuropeptide Y receptor	0.0162	0.0951	0.1047
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0162	0.0951	0.2157
Echinococcus multilocularis	ferritin	0.0038	0.0045	0.005
Onchocerca volvulus		0.0219	0.1368	0.26
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0099	0.0489	0.0962
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0117	0.062	0.0682
Brugia malayi	GnHR receptor homolog	0.0162	0.0951	0.2142
Loa Loa (eye worm)	hypothetical protein	0.0219	0.1368	0.308
Loa Loa (eye worm)	hypothetical protein	0.004	0.0061	0.0138
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0108	0.0554	0.109
Schistosoma mansoni	jumonji domain containing protein	0.0168	0.0995	0.2257
Loa Loa (eye worm)	hypothetical protein	0.004	0.0061	0.0138
Echinococcus granulosus	rhodopsin orphan GPCR	0.0162	0.0951	0.1047
Brugia malayi	FAT domain containing protein	0.0038	0.0046	0.0103
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0049	0.0128	0.0251
Onchocerca volvulus		0.0162	0.0951	0.1771
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0162	0.0951	0.2142
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0064	0.0238	0.0541
Brugia malayi	Melatonin receptor type 1A	0.0162	0.0951	0.2142
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0219	0.1368	0.308
Schistosoma mansoni	ferritin	0.0038	0.0045	0.0102
Trichomonas vaginalis	penicillin-binding protein, putative	0.0219	0.1368	0.2689
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0117	0.062	0.2519
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0162	0.0951	0.2142
Schistosoma mansoni	ferritin	0.0038	0.0045	0.0102
Echinococcus granulosus	orexin receptor type 2	0.0162	0.0951	0.1047
Schistosoma mansoni	hypothetical protein	0.0162	0.0951	0.2157
Echinococcus multilocularis	neuropeptides capa receptor	0.0162	0.0951	0.1047
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0108	0.0555	0.1691
Loa Loa (eye worm)	hypothetical protein	0.0168	0.0998	0.2249
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0219	0.1368	0.1329
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0162	0.0951	0.2142
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0047	0.0109	0.0245
Loa Loa (eye worm)	transcription factor SMAD2	0.0234	0.1482	0.3338
Mycobacterium ulcerans	lipase LipD	0.0219	0.1368	1
Brugia malayi	Serotonin receptor	0.0162	0.0951	0.2142
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0088	0.0407	0.0917
Loa Loa (eye worm)	TYRA-2 protein	0.0162	0.0951	0.2142
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Echinococcus granulosus	rhodopsin orphan GPCR	0.0162	0.0951	0.1047
Echinococcus granulosus	dro:myosuppressin receptor	0.0162	0.0951	0.1047
Plasmodium falciparum	ataxin-2 like protein, putative	0.0052	0.0144	0.4682
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0046	0.009
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0436	0.0983
Schistosoma mansoni	hypothetical protein	0.0162	0.0951	0.2157
Brugia malayi	Pre-SET motif family protein	0.0091	0.0436	0.0983
Echinococcus multilocularis	geminin	0.0181	0.1091	0.1201
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0162	0.0951	0.1047
Loa Loa (eye worm)	hypothetical protein	0.0237	0.1506	0.3391
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0161	0.0949	0.2138
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0105	0.0538	0.1057
Brugia malayi	neuropeptide F receptor	0.0162	0.0951	0.2142
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0162	0.0951	0.1047
Echinococcus granulosus	somatostatin receptor	0.0162	0.0951	0.1047
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0162	0.0951	0.1047
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Echinococcus multilocularis	neuropeptide Y receptor	0.0162	0.0951	0.1047
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0049	0.0128	0.08
Echinococcus granulosus	fmrfamide receptor	0.0162	0.0951	0.1047
Echinococcus granulosus	ferritin	0.0038	0.0045	0.005
Echinococcus granulosus	microtubule associated protein 2	0.0634	0.4409	0.4854
Loa Loa (eye worm)	hypothetical protein	0.0237	0.1506	0.3391
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.004	0.0061	0.0067
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0091	0.0436	0.2871
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0161	0.0949	0.1045
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0162	0.0951	0.1047
Loa Loa (eye worm)	PHD-finger family protein	0.0064	0.0238	0.0537
Schistosoma mansoni	hypothetical protein	0.0181	0.1091	0.2474
Schistosoma mansoni	apoferritin-2	0.0038	0.0045	0.0102
Entamoeba histolytica	DNA repair and recombination protein RAD52, putative	0.0376	0.2519	1
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0162	0.0951	0.1047
Echinococcus granulosus	voltage gated potassium channel	0.0047	0.0109	0.012
Echinococcus granulosus	neuropeptide receptor	0.0162	0.0951	0.1047
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0162	0.0951	0.2157
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0117	0.062	0.4451
Toxoplasma gondii	LsmAD domain-containing protein	0.0052	0.0144	0.0635
Echinococcus multilocularis	orexin receptor type 2	0.0162	0.0951	0.1047
Echinococcus multilocularis	neuropeptide s receptor	0.0162	0.0951	0.1047
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0162	0.0951	0.1047
Onchocerca volvulus		0.0091	0.0436	0.0747
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0162	0.0951	0.1047
Echinococcus multilocularis	g protein coupled receptor	0.0162	0.0951	0.1047
Schistosoma mansoni	hypothetical protein	0.0064	0.0238	0.0541
Echinococcus granulosus	neuropeptide s receptor	0.0162	0.0951	0.1047
Echinococcus multilocularis	serotonin receptor	0.0162	0.0951	0.1047
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0162	0.0951	0.2157
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0096	0.0472	0.0929
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0162	0.0951	0.2157
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Brugia malayi	hypothetical protein	0.0162	0.0951	0.2142
Brugia malayi	Dopamine receptor protein 2	0.0162	0.0951	0.2142
Echinococcus multilocularis	tumor protein p63	0.1271	0.9084	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0108	0.0554	0.109
Schistosoma mansoni	ferritin light chain	0.0038	0.0045	0.0102
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0049	0.0128	0.0505
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0219	0.1368	0.1506
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0162	0.0951	0.1047
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0162	0.0951	0.1047
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Schistosoma mansoni	opsin-like receptor	0.0162	0.0951	0.2157
Echinococcus multilocularis	expressed protein	0.0038	0.0045	0.005
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0004	0.0009
Onchocerca volvulus		0.0162	0.0951	0.1771
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0211	0.1313	0.1446
Onchocerca volvulus		0.0162	0.0951	0.1771
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0088	0.0407	0.0924
Onchocerca volvulus		0.0162	0.0951	0.1771
Mycobacterium tuberculosis	Conserved protein	0.0219	0.1368	0.1329
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.004	0.0061	0.0138
Schistosoma mansoni	opsin-like receptor	0.0162	0.0951	0.2157
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0238	0.0537
Brugia malayi	hypothetical protein	0.0162	0.0951	0.2142
Loa Loa (eye worm)	melatonin receptor type 1A	0.0162	0.0951	0.2142
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0067	0.0258	0.0508
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0091	0.0436	0.048
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0108	0.0554	0.109
Mycobacterium tuberculosis	Conserved protein	0.0219	0.1368	0.1329
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0211	0.1313	0.1446
Onchocerca volvulus		0.0162	0.0951	0.1771
Brugia malayi	ORL1-like opioid receptor	0.0162	0.0951	0.2142
Echinococcus granulosus	neuropeptide FF receptor 2	0.0162	0.0951	0.1047
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0162	0.0951	0.1047
Echinococcus granulosus	G protein coupled receptor 139	0.0162	0.0951	0.1047
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0162	0.0951	0.2157
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.004	0.0061	0.0138
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0162	0.0951	0.1047
Mycobacterium ulcerans	esterase/lipase LipP	0.0219	0.1368	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0162	0.0951	0.2157
Brugia malayi	beta-lactamase family protein	0.0219	0.1368	0.308
Brugia malayi	follicle stimulating hormone receptor	0.0162	0.0951	0.2142
Echinococcus granulosus	jumonji domain containing protein	0.009	0.0423	0.0466
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0117	0.062	0.1218
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0096	0.0473	0.0929
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.1049	0.7455	0.8207
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0162	0.0951	0.2157
Brugia malayi	latrophilin 2 splice variant baaae	0.0038	0.0044	0.0099
Brugia malayi	G protein-coupled receptor	0.0162	0.0951	0.2142
Brugia malayi	Serotonin receptor	0.0162	0.0951	0.2142
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0064	0.0234	0.1592
Mycobacterium ulcerans	hypothetical protein	0.0219	0.1368	1
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0049	0.0128	0.0289
Brugia malayi	hypothetical protein	0.0162	0.0951	0.2142
Loa Loa (eye worm)	beta-lactamase	0.0219	0.1368	0.308
Echinococcus multilocularis	G protein coupled receptor 139	0.0162	0.0951	0.1047
Mycobacterium ulcerans	beta-lactamase	0.0219	0.1368	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0049	0.0128	0.0251
Onchocerca volvulus	Alhambra homolog	0.0064	0.0238	0.0353
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0219	0.1368	0.1329
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Trichomonas vaginalis	D-aminoacylase, putative	0.0219	0.1368	0.2689
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.004	0.0061	0.0138
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0049	0.0128	0.0287
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0038	0.0046	0.005
Schistosoma mansoni	apoferritin-2	0.0038	0.0045	0.0102
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0237	0.1506	0.3391
Plasmodium vivax	ataxin-2 like protein, putative	0.0052	0.0144	0.0635
Mycobacterium tuberculosis	Probable hydrolase	0.0219	0.1368	0.1329
Entamoeba histolytica	hypothetical protein	0.0107	0.0549	0.1763
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0088	0.0407	0.0801
Echinococcus granulosus	rhodopsin orphan GPCR	0.0162	0.0951	0.1047
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0162	0.0951	0.1047
Schistosoma mansoni	sodium/chloride dependent transporter	0.004	0.0061	0.0139
Trichomonas vaginalis	penicillin-binding protein, putative	0.0219	0.1368	0.2689
Schistosoma mansoni	histamine h1 receptor	0.0162	0.0951	0.2157
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Schistosoma mansoni	biogenic amine receptor	0.0162	0.0951	0.2157
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0096	0.0473	0.0929
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0109	0.0245
Onchocerca volvulus		0.0237	0.1506	0.2875
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0161	0.0949	0.2138
Echinococcus granulosus	tm gpcr rhodopsin	0.0162	0.0951	0.1047
Onchocerca volvulus		0.0162	0.0951	0.1771
Brugia malayi	G protein-coupled receptor F59B2.13	0.0162	0.0951	0.2142
Trichomonas vaginalis	ferritin, putative	0.0038	0.0045	0.0089
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0162	0.0951	0.1047
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0162	0.0951	0.1047
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.004	0.0061	0.0139
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0162	0.0951	0.2157
Echinococcus granulosus	geminin	0.0181	0.1091	0.1201
Loa Loa (eye worm)	hypothetical protein	0.0186	0.113	0.2544
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Mycobacterium tuberculosis	Conserved protein	0.0219	0.1368	0.1329
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0219	0.1368	0.1329
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0088	0.0407	0.1084
Schistosoma mansoni	microtubule-associated protein tau	0.0634	0.4409	1
Schistosoma mansoni	ferritin	0.0038	0.0045	0.0102
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0088	0.0407	0.0801
Loa Loa (eye worm)	hypothetical protein	0.0219	0.1368	0.308
Schistosoma mansoni	voltage-gated potassium channel	0.0047	0.0109	0.0247
Echinococcus granulosus	biogenic amine 5HT receptor	0.0162	0.0951	0.1047
Onchocerca volvulus		0.0162	0.0951	0.1771
Loa Loa (eye worm)	hypothetical protein	0.004	0.0061	0.0138
Schistosoma mansoni	voltage-gated potassium channel	0.0176	0.1058	0.24
Onchocerca volvulus		0.0219	0.1368	0.26
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0162	0.0951	0.2142
Echinococcus granulosus	g-protein coupled receptor	0.0162	0.0951	0.1047
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.004	0.0061	0.0067
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0049	0.0128	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0219	0.1368	0.308
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0105	0.0538	0.1057
Echinococcus multilocularis	g protein coupled receptor	0.0162	0.0951	0.1047
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0108	0.0554	0.109
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Brugia malayi	AKH receptor	0.0162	0.0951	0.2142
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0162	0.0951	0.2157
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0055	0.0169	0.0825
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0162	0.0951	0.2157
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0162	0.0951	0.1771
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0237	0.1506	0.3415
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0162	0.0951	0.1047
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0067	0.0258	0.0508
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0111	0.0579	0.0637
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0162	0.0951	0.2142
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0049	0.0128	0.014
Echinococcus granulosus	neuropeptides capa receptor	0.0162	0.0951	0.1047
Brugia malayi	Bromodomain containing protein	0.0064	0.0238	0.0537
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.004	0.0061	0.0139
Onchocerca volvulus		0.0162	0.0951	0.1771
Schistosoma mansoni	biogenic amine receptor	0.0162	0.0951	0.2157
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Loa Loa (eye worm)	hypothetical protein	0.0219	0.1368	0.308
Plasmodium vivax	hypothetical protein, conserved	0.0064	0.0238	0.1356
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.004	0.0061	0.0139
Loa Loa (eye worm)	hypothetical protein	0.004	0.0061	0.0138
Loa Loa (eye worm)	phosphatidylinositol 3	0.0088	0.0407	0.0917
Echinococcus multilocularis	serotonin receptor	0.0162	0.0951	0.1047
Schistosoma mansoni	sodium/chloride dependent transporter	0.004	0.0061	0.0139
Brugia malayi	hypothetical protein	0.0162	0.0951	0.2142
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.004	0.0061	0.0139
Echinococcus granulosus	g protein coupled receptor	0.0162	0.0951	0.1047
Schistosoma mansoni	hypothetical protein	0.0038	0.0044	0.0099
Brugia malayi	hypothetical protein	0.0162	0.0951	0.2142
Brugia malayi	hypothetical protein	0.0033	0.001	0.0023
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0105	0.0538	0.3648
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0117	0.062	0.2058
Onchocerca volvulus		0.0168	0.0998	0.1865
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0088	0.0407	0.0801
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0108	0.0555	0.3968
Echinococcus multilocularis	serotonin transporter	0.0237	0.1506	0.1658
Onchocerca volvulus		0.0162	0.0951	0.1771
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0173	0.0388
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0162	0.0951	0.1047
Echinococcus multilocularis	jumonji domain containing protein	0.009	0.0423	0.0466
Onchocerca volvulus		0.0162	0.0951	0.1771
Schistosoma mansoni	amine GPCR	0.0162	0.0951	0.2157
Echinococcus granulosus	hypothetical protein	0.0162	0.0951	0.1047
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0162	0.0951	0.2157
Echinococcus granulosus	rhodopsin orphan GPCR	0.0162	0.0951	0.1047
Schistosoma mansoni	hypothetical protein	0.0181	0.1091	0.2474
Echinococcus granulosus	tm gpcr rhodopsin	0.0162	0.0951	0.1047
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0162	0.0951	0.1047
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0004	0.0008
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0162	0.0951	0.1047
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Toxoplasma gondii	ABC1 family protein	0.0219	0.1368	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0162	0.0951	0.1047
Loa Loa (eye worm)	norepinephrine transporter	0.0237	0.1506	0.3391
Giardia lamblia	GTOR	0.0117	0.062	0.1672
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Loa Loa (eye worm)	serotonin transporter b	0.0237	0.1506	0.3391
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0219	0.1368	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0162	0.0951	0.1047
Brugia malayi	beta-lactamase	0.0219	0.1368	0.308
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0162	0.0951	0.1047
Schistosoma mansoni	neuropeptide receptor	0.0162	0.0951	0.2157
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Echinococcus multilocularis	g-protein coupled receptor	0.0162	0.0951	0.1047
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0049	0.0128	0.0287
Echinococcus multilocularis	neuropeptide Y receptor	0.0162	0.0951	0.1047
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0151	0.0871	0.1713
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0049	0.0128	0.0289
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0237	0.1506	0.3391
Loa Loa (eye worm)	hypothetical protein	0.004	0.0061	0.0138
Trichomonas vaginalis	conserved hypothetical protein	0.0055	0.0169	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Brugia malayi	hypothetical protein	0.0102	0.0514	0.1157
Brugia malayi	hypothetical protein	0.0162	0.0951	0.2142
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0117	0.062	0.2058
Brugia malayi	Dopamine receptor protein 1	0.0162	0.0951	0.2142
Brugia malayi	neuropeptide F receptor	0.0162	0.0951	0.2142
Plasmodium vivax	hypothetical protein, conserved	0.0219	0.1368	1
Entamoeba histolytica	hypothetical protein	0.0111	0.0579	0.1887
Schistosoma mansoni	myosin xvIII	0.0162	0.0951	0.2157
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Echinococcus multilocularis	serine protein kinase ATM	0.0049	0.0128	0.014
Schistosoma mansoni	amine GPCR	0.0162	0.0951	0.2157
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Echinococcus granulosus	beta LACTamase domain containing family member	0.0219	0.1368	0.1506
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Echinococcus granulosus	PHD finger protein rhinoceros	0.0064	0.0238	0.0262
Brugia malayi	sulfakinin receptor protein	0.0162	0.0951	0.2142
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0162	0.0951	0.2142
Entamoeba histolytica	hypothetical protein	0.0111	0.0579	0.1887
Brugia malayi	hypothetical protein	0.0162	0.0951	0.2142
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0162	0.0951	0.1047
Brugia malayi	jmjC domain containing protein	0.0211	0.1313	0.2958
Trichomonas vaginalis	D-aminoacylase, putative	0.0219	0.1368	0.2689
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0046	0.0103
Mycobacterium tuberculosis	Probable esterase LipL	0.0219	0.1368	0.1329
Schistosoma mansoni	ferritin light chain	0.0038	0.0045	0.0102
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.1049	0.7455	0.8207
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0117	0.062	0.1218
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.004	0.0061	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0219	0.1368	0.308
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0514	0.1157
Echinococcus multilocularis	fmrfamide receptor	0.0162	0.0951	0.1047
Trypanosoma cruzi	hypothetical protein, conserved	0.0219	0.1368	0.5579
Trypanosoma cruzi	PAB1-binding protein , putative	0.0052	0.0144	0.0573
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.004	0.0061	0.0067
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0162	0.0951	0.2157
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0576	0.1297
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0162	0.0951	0.1047
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0162	0.0951	0.1047
Brugia malayi	PHD-finger family protein	0.0064	0.0238	0.0537
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0162	0.0951	0.1047
Brugia malayi	hypothetical protein	0.0162	0.0951	0.2142
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0162	0.0951	0.2157
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0117	0.062	0.1959
Schistosoma mansoni	amine GPCR	0.0162	0.0951	0.2157
Loa Loa (eye worm)	G-protein coupled receptor	0.0162	0.0951	0.2142
Entamoeba histolytica	hypothetical protein	0.0111	0.0579	0.1887
Mycobacterium leprae	conserved hypothetical protein	0.0219	0.1368	1
Echinococcus granulosus	serotonin receptor	0.0162	0.0951	0.1047
Echinococcus multilocularis	neuropeptides capa receptor	0.0162	0.0951	0.1047
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.004	0.0061	0.0067
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.004	0.0061	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0162	0.0951	0.1047
Mycobacterium leprae	Probable lipase LipE	0.0219	0.1368	1
Echinococcus multilocularis	somatostatin receptor	0.0162	0.0951	0.1047
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0047	0.0109	0.012
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Schistosoma mansoni	growth hormone secretagogue receptor	0.0162	0.0951	0.2157
Echinococcus multilocularis	allatostatin A receptor	0.0162	0.0951	0.1047
Trypanosoma cruzi	hypothetical protein, conserved	0.0366	0.2448	1
Schistosoma mansoni	biogenic amine receptor	0.0162	0.0951	0.2157
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Onchocerca volvulus		0.0186	0.113	0.2126
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0091	0.0436	0.048
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0162	0.0951	0.2142
Echinococcus granulosus	lysine specific demethylase 5A	0.0078	0.0338	0.0372
Onchocerca volvulus		0.0162	0.0951	0.1771
Schistosoma mansoni	amine GPCR	0.0162	0.0951	0.2157
Schistosoma mansoni	neuropeptide receptor	0.0162	0.0951	0.2157
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0044	0.0099
Echinococcus multilocularis	neuropeptide receptor A26	0.0162	0.0951	0.1047
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0047	0.0109	0.012
Schistosoma mansoni	sodium/chloride dependent transporter	0.0237	0.1506	0.3415
Echinococcus granulosus	histone lysine methyltransferase setb	0.0091	0.0436	0.048
Toxoplasma gondii	FATC domain-containing protein	0.0049	0.0128	0.0508
Giardia lamblia	DNA repair protein RAD52	0.0376	0.2519	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0067	0.0258	0.0508
Brugia malayi	jmjC domain containing protein	0.0078	0.0338	0.0761
Echinococcus multilocularis	lysine specific demethylase 5A	0.0078	0.0338	0.0372
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0162	0.0951	0.2142
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0128	0.0287
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0078	0.0338	0.0766
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0111	0.0579	0.0637
Schistosoma mansoni	hypothetical protein	0.0162	0.0951	0.2157
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0162	0.0951	0.2157
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0117	0.062	0.1218
Trypanosoma brucei	PAB1-binding protein , putative	0.0052	0.0144	0.0923
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0105	0.0538	0.1057
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0162	0.0951	0.2157
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0162	0.0951	0.1047
Toxoplasma gondii	PHD-finger domain-containing protein	0.0064	0.0238	0.1356
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0162	0.0951	0.2157
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Echinococcus multilocularis	voltage gated potassium channel	0.0047	0.0109	0.012
Brugia malayi	beta-lactamase family protein	0.0219	0.1368	0.308
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Trichomonas vaginalis	D-aminoacylase, putative	0.0219	0.1368	0.2689
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0064	0.0238	0.0262
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0038	0.0046	0.005
Echinococcus granulosus	neuropeptides capa receptor	0.0162	0.0951	0.1047
Mycobacterium tuberculosis	Probable lipase LipE	0.0219	0.1368	0.1329
Trypanosoma brucei	hypothetical protein, conserved	0.0219	0.1368	1
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.004	0.0061	0.0139
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0055	0.0173	0.0388
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0096	0.0473	0.0929
Schistosoma mansoni	adenoreceptor	0.0162	0.0951	0.2157
Schistosoma mansoni	transcription factor LCR-F1	0.0111	0.0579	0.1313
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0162	0.0951	0.1047
Mycobacterium tuberculosis	Probable lipase LipD	0.0219	0.1368	0.1329
Leishmania major	hypothetical protein, conserved	0.0383	0.2571	1
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Echinococcus multilocularis	peregrin	0.0064	0.0238	0.0262
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0088	0.0407	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Brugia malayi	putative neuropeptide receptor NPR1	0.0162	0.0951	0.2142
Trichomonas vaginalis	esterase, putative	0.0219	0.1368	0.2689
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0162	0.0951	0.2157
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0117	0.062	0.1959
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0105	0.0538	0.1057
Brugia malayi	hypothetical protein	0.004	0.0061	0.0138
Brugia malayi	hypothetical protein	0.0162	0.0951	0.2142
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0162	0.0951	0.1047
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0075	0.0316	0.0621
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0638	0.4441	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0105	0.0538	0.1057
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0049	0.0128	0.014
Echinococcus granulosus	7tm_1 domain containing protein	0.0162	0.0951	0.1047
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0088	0.0407	0.1649
Schistosoma mansoni	sodium-dependent amino acid transporter	0.004	0.0061	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0144	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0162	0.0951	0.2157
Onchocerca volvulus		0.0162	0.0951	0.1771
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0161	0.0949	0.1045
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Entamoeba histolytica	Rad52/22 family double-strand break repair protein, putative	0.0107	0.0549	0.1763
Brugia malayi	RE15519p	0.0162	0.0951	0.2142
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0162	0.0951	0.2142
Brugia malayi	larval opioid receptor	0.0162	0.0951	0.2142
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0219	0.1368	0.3102
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.004	0.0061	0.0138
Onchocerca volvulus		0.0726	0.5086	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0091	0.0436	0.099
Echinococcus granulosus	sodium and chloride dependent glycine	0.004	0.0061	0.0067
Echinococcus multilocularis	g protein coupled receptor	0.0162	0.0951	0.1047
Brugia malayi	hypothetical protein	0.0162	0.0951	0.2142
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Treponema pallidum	sodium- and chloride- dependent transporter	0.0237	0.1506	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0099	0.0489	0.0962
Echinococcus granulosus	serine protein kinase ATM	0.0049	0.0128	0.014
Echinococcus granulosus	neuropeptide receptor	0.0162	0.0951	0.1047
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.0275	0.054
Loa Loa (eye worm)	phosphatidylinositol 3	0.0117	0.062	0.1396
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0169	0.038
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0055	0.0173	0.0388
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0096	0.0472	0.0929
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0162	0.0951	0.2157
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0105	0.0538	0.1057
Brugia malayi	Pre-SET motif family protein	0.0638	0.4441	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0088	0.0407	0.0801
Echinococcus granulosus	neuropeptide Y receptor	0.0162	0.0951	0.1047
Schistosoma mansoni	neuropeptide F-like receptor	0.0162	0.0951	0.2157
Plasmodium falciparum	phd finger protein, putative	0.0064	0.0238	1
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0088	0.0407	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0162	0.0951	0.1047
Echinococcus multilocularis	sodium and chloride dependent glycine	0.004	0.0061	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Schistosoma mansoni	opsin-like receptor	0.0162	0.0951	0.2157
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0108	0.0554	0.109
Echinococcus granulosus	g protein coupled receptor	0.0162	0.0951	0.1047
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.004	0.0061	0.0067
Schistosoma mansoni	neuropeptide receptor	0.0162	0.0951	0.2157
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0514	0.1157
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0162	0.0951	0.2157
Echinococcus multilocularis	fmrfamide receptor	0.0162	0.0951	0.1047
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0162	0.0951	0.1047
Plasmodium vivax	SET domain protein, putative	0.0091	0.0436	0.2871
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0117	0.062	0.0682
Echinococcus granulosus	serotonin transporter	0.0237	0.1506	0.1658
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.004	0.0061	0.0138
Trypanosoma cruzi	PAB1-binding protein , putative	0.0052	0.0144	0.0573
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0219	0.1368	0.3102
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.004	0.0061	0.0067
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0162	0.0951	0.1047
Loa Loa (eye worm)	G-protein coupled receptor	0.0162	0.0951	0.2142
Echinococcus granulosus	tumor protein p63	0.1271	0.9084	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0162	0.0951	0.1047
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0088	0.0407	0.2875
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0117	0.062	0.4451
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0162	0.0951	0.2157
Echinococcus granulosus	rhodopsin orphan GPCR	0.0162	0.0951	0.1047
Brugia malayi	G-protein coupled receptor	0.0162	0.0951	0.2142
Schistosoma mansoni	neuropeptide receptor	0.0162	0.0951	0.2157
Schistosoma mansoni	neuropeptide f receptor 76f	0.0162	0.0951	0.2157
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0088	0.0407	0.1649
Schistosoma mansoni	voltage-gated potassium channel	0.0047	0.0109	0.0247
Loa Loa (eye worm)	neuropeptide F receptor	0.0162	0.0951	0.2142
Echinococcus granulosus	tm gpcr rhodopsin	0.0162	0.0951	0.1047
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.004	0.0061	0.0139
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0004	0.0008
Echinococcus granulosus	expressed protein	0.0038	0.0045	0.005
Loa Loa (eye worm)	hypothetical protein	0.0237	0.1506	0.3391
Onchocerca volvulus		0.0162	0.0951	0.1771
Onchocerca volvulus		0.0162	0.0951	0.1771
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0151	0.0871	0.1713
Entamoeba histolytica	hypothetical protein	0.0111	0.0579	0.1887
Brugia malayi	hypothetical protein	0.0168	0.0998	0.2249
Plasmodium falciparum	ataxin-2 like protein, putative	0.0052	0.0144	0.4682
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0049	0.0128	0.0505
Onchocerca volvulus		0.0162	0.0951	0.1771
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0078	0.034	0.0669
Echinococcus multilocularis	sodium and chloride dependent glycine	0.004	0.0061	0.0067
Brugia malayi	hypothetical protein	0.0111	0.0579	0.1304
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0117	0.062	0.1405
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0162	0.0951	0.1047
Loa Loa (eye worm)	hypothetical protein	0.014	0.0793	0.1786
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0162	0.0951	0.2157
Loa Loa (eye worm)	hypothetical protein	0.004	0.0061	0.0138
Schistosoma mansoni	ferritin	0.0038	0.0045	0.0102
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0162	0.0951	0.1047
Onchocerca volvulus		0.0162	0.0951	0.1771
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0078	0.0338	0.0766
Echinococcus multilocularis	microtubule associated protein 2	0.0634	0.4409	0.4854
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0117	0.062	0.1396
Loa Loa (eye worm)	neuropeptide F receptor	0.0162	0.0951	0.2142
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0162	0.0951	0.2142
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0088	0.0407	0.2875
Echinococcus granulosus	rhodopsin orphan GPCR	0.0162	0.0951	0.1047
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.004	0.0061	0.0067
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0055	0.0173	0.0388
Schistosoma mansoni	amine GPCR	0.0162	0.0951	0.2157
Brugia malayi	Dopamine receptor	0.0162	0.0951	0.2142
Echinococcus multilocularis	neuropeptide receptor	0.0162	0.0951	0.1047
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.004	0.0061	0.0139
Brugia malayi	MH2 domain containing protein	0.0234	0.1482	0.3338
Loa Loa (eye worm)	hypothetical protein	0.004	0.0061	0.0138
Loa Loa (eye worm)	jmjC domain-containing protein	0.0078	0.0338	0.0761
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0162	0.0951	0.2157
Echinococcus multilocularis	dro:myosuppressin receptor	0.0162	0.0951	0.1047
Brugia malayi	putative neuropeptide receptor	0.0162	0.0951	0.2142
Echinococcus granulosus	peregrin	0.0064	0.0238	0.0262
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0162	0.0951	0.2142
Brugia malayi	G-protein coupled receptor	0.0162	0.0951	0.2142
Wolbachia endosymbiont of Brugia malayi	bacterioferritin/cytochrome b1	0.0038	0.0045	0.5
Toxoplasma gondii	PHD-finger domain-containing protein	0.0064	0.0238	0.1356
Echinococcus multilocularis	sex peptide receptor	0.0162	0.0951	0.1047
Trypanosoma cruzi	hypothetical protein, conserved	0.0219	0.1368	0.5579
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0096	0.0473	0.0929
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0117	0.062	0.2519
Echinococcus multilocularis	neuropeptide receptor	0.0162	0.0951	0.1047
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0951	0.2142
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0162	0.0951	0.1771
Loa Loa (eye worm)	hypothetical protein	0.0219	0.1368	0.308
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0162	0.0951	0.2157
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0219	0.1368	0.308
Schistosoma mansoni	cellular tumor antigen P53	0.0186	0.113	0.2562
Onchocerca volvulus		0.0219	0.1368	0.26
Schistosoma mansoni	hypothetical protein	0.0038	0.0046	0.0103
Echinococcus granulosus	g protein coupled receptor	0.0162	0.0951	0.1047
Echinococcus granulosus	allatostatin A receptor	0.0162	0.0951	0.1047
Loa Loa (eye worm)	MH2 domain-containing protein	0.0234	0.1482	0.3338
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0088	0.0407	0.0801
Schistosoma mansoni	hypothetical protein	0.0111	0.0579	0.1313
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0091	0.0436	0.099

Activities

Activity type	Activity value	Assay description	Source	Reference
ED50 (functional)	> 10 nM	In vitro 50 % Maximal response in jugular vein expressing B2 receptor	ChEMBL.	6118437
pD (functional)	< 4 M	In vitro 50 % Maximal response in jugular vein expressing B2 receptor	ChEMBL.	6118437
Relative affinity (functional)	< 0.01 %	Percent agonistic activity in rabbit jugular vein expressing B2 receptor relative to bradykinin	ChEMBL.	6118437

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: 143914

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 377953