Detailed information for compound 402723

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1064.14 | Formula: C52H69N7O17
  • H donors: 14 H acceptors: 16 LogP: 0.82 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 4
  • SMILES: CCCCC(C(=O)N[C@@H]1C[C@@H](O)[C@@H](O)NC(=O)C2[C@@H](O)[C@H](CN2C(=O)C(NC(=O)C(NC(=O)C2N(C(=O)C(NC1=O)C(O)C)C[C@@H](C2)O)[C@H]([C@H](c1ccc(cc1)O)O)O)C(O)C)C)Oc1ccc(cc1)c1ccccc1
  • InChi: 1S/C52H69N7O17/c1-5-6-12-37(76-33-19-15-29(16-20-33)28-10-8-7-9-11-28)48(71)53-34-22-36(64)47(70)57-50(73)41-42(65)25(2)23-59(41)52(75)39(27(4)61)55-49(72)40(44(67)43(66)30-13-17-31(62)18-14-30)56-46(69)35-21-32(63)24-58(35)51(74)38(26(3)60)54-45(34)68/h7-11,13-20,25-27,32,34-44,47,60-67,70H,5-6,12,21-24H2,1-4H3,(H,53,71)(H,54,68)(H,55,72)(H,56,69)(H,57,73)/t25-,26?,27?,32+,34-,35?,36+,37?,38?,39?,40?,41?,42-,43-,44-,47+/m0/s1
  • InChiKey: QAFLCRPTOZYECX-UXEGEOGCSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi ecdysone receptor 0.002 0.0029 0.0034
Loa Loa (eye worm) hypothetical protein 0.0116 0.0909 0.1139
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0025 0.0076 0.0077
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0026 0.0087 0.0109
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0116 0.0909 0.1064
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0068 0.0086
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0047 0.0282 0.0274
Brugia malayi hypothetical protein 0.0158 0.1298 0.1521
Echinococcus granulosus neuropeptide Y receptor 0.0158 0.1298 0.1292
Loa Loa (eye worm) hypothetical protein 0.0158 0.1298 0.1627
Schistosoma mansoni neuropeptide receptor 0.0158 0.1298 0.1619
Echinococcus granulosus g protein coupled receptor 0.0158 0.1298 0.1292
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0889 0.7981 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0158 0.1298 0.1292
Brugia malayi neuropeptide F receptor 0.0158 0.1298 0.1521
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.014 0.0157
Schistosoma mansoni nAChR subunit 0.021 0.177 0.221
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0066 0.0452 0.0444
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0116 0.0909 0.113
Loa Loa (eye worm) hypothetical protein 0.0158 0.1298 0.1627
Echinococcus multilocularis serotonin receptor 0.0368 0.3215 0.321
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0028 0.0105 0.0132
Echinococcus granulosus hypothetical protein 0.0951 0.855 0.8549
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.021 0.177 0.2073
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0229 0.0278
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.021 0.177 0.221
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0229 0.0287
Echinococcus multilocularis rhodopsin orphan GPCR 0.0158 0.1298 0.1292
Brugia malayi putative neuropeptide receptor 0.0158 0.1298 0.1521
Loa Loa (eye worm) nuclear receptor NHR-67 0.002 0.0029 0.0037
Loa Loa (eye worm) G-protein coupled receptor 0.0158 0.1298 0.1627
Schistosoma mansoni hypothetical protein 0.0158 0.1298 0.1619
Brugia malayi FAD binding domain containing protein 0.0017 0.0008 0.0009
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0889 0.7981 0.9348
Echinococcus granulosus glycine receptor subunit beta 0.021 0.177 0.1763
Brugia malayi larval opioid receptor 0.0158 0.1298 0.1521
Schistosoma mansoni hypothetical protein 0.0066 0.0452 0.0557
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.002 0.0029 0.0034
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0889 0.7981 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.0712 0.0892
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0047 0.0282 0.0344
Brugia malayi nuclear receptor NHR-88 0.002 0.0029 0.0034
Echinococcus granulosus tachykinin peptides receptor 99D 0.0158 0.1298 0.1292
Echinococcus multilocularis neuropeptide s receptor 0.0398 0.3495 0.349
Schistosoma mansoni amine GPCR 0.0158 0.1298 0.1619
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0229 0.0278
Brugia malayi Melatonin receptor type 1A 0.0158 0.1298 0.1521
Leishmania major cytochrome P450 reductase, putative 0.0025 0.0076 0.0095
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0158 0.1298 0.1619
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0038
Schistosoma mansoni myosin xvIII 0.0158 0.1298 0.1619
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0158 0.1298 0.1521
Echinococcus multilocularis neuropeptide Y receptor 0.0158 0.1298 0.1292
Brugia malayi nuclear receptor RXR 0.0022 0.0051 0.0059
Echinococcus multilocularis fmrfamide receptor 0.0158 0.1298 0.1292
Plasmodium vivax amine transporter, putative 0.0047 0.0282 0.0323
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0037
Schistosoma mansoni nuclear receptor 0.002 0.0029 0.0027
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0229 0.0847
Trichomonas vaginalis penicillin-binding protein, putative 0.0024 0.0068 0.0067
Loa Loa (eye worm) hypothetical protein 0.0047 0.0282 0.0353
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0229 0.0278
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0229 0.0269
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0229 0.0269
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0158 0.1298 0.1292
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0047 0.0282 0.0274
Echinococcus granulosus neuropeptide receptor 0.0158 0.1298 0.1292
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0047 0.0282 0.0323
Echinococcus multilocularis neuropeptide receptor 0.0158 0.1298 0.1292
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0158 0.1298 0.1619
Loa Loa (eye worm) hypothetical protein 0.0029 0.012 0.015
Loa Loa (eye worm) hypothetical protein 0.0158 0.1298 0.1627
Loa Loa (eye worm) hypothetical protein 0.0024 0.0068 0.0086
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0019 0.0027 0.0019
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.0229 0.0222
Schistosoma mansoni sodium/chloride dependent transporter 0.0047 0.0282 0.0344
Loa Loa (eye worm) hypothetical protein 0.0041 0.0229 0.0287
Loa Loa (eye worm) norepinephrine transporter 0.0278 0.2391 0.2996
Schistosoma mansoni growth hormone secretagogue receptor 0.0158 0.1298 0.1619
Loa Loa (eye worm) hypothetical protein 0.021 0.177 0.2217
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0029 0.0021
Loa Loa (eye worm) ACC-1 protein 0.021 0.177 0.2217
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.021 0.177 0.221
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.021 0.177 0.1763
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0061 0.0408 0.0511
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0029 0.012 0.0112
Loa Loa (eye worm) hypothetical protein 0.0158 0.1298 0.1627
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0061 0.0408 0.04
Loa Loa (eye worm) hypothetical protein 0.0116 0.0909 0.1139
Loa Loa (eye worm) hypothetical protein 0.0603 0.5371 0.6729
Leishmania major C-8 sterol isomerase-like protein 0.0423 0.372 0.4661
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0229 0.0847
Echinococcus multilocularis sex peptide receptor 0.0158 0.1298 0.1292
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0229 0.0269
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0769 0.6888 0.8068
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0061 0.0408 0.0511
Loa Loa (eye worm) hypothetical protein 0.0158 0.1298 0.1627
Brugia malayi Dopamine receptor 0.0158 0.1298 0.1521
Brugia malayi hypothetical protein 0.0019 0.0022 0.0026
Loa Loa (eye worm) hypothetical protein 0.021 0.177 0.2217
Brugia malayi Importin beta-1 subunit 0.0019 0.0025 0.0029
Onchocerca volvulus 0.0158 0.1298 0.5373
Onchocerca volvulus Putative nachr subunit 0.021 0.177 0.7369
Loa Loa (eye worm) hypothetical protein 0.0158 0.1298 0.1627
Onchocerca volvulus 0.002 0.0034 0.002
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0158 0.1298 0.1292
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0158 0.1298 0.1627
Echinococcus granulosus glycine receptor subunit alpha 1 0.021 0.177 0.1763
Schistosoma mansoni hypothetical protein 0.0088 0.066 0.0817
Echinococcus granulosus intermediate filament protein 0.002 0.0034 0.0026
Plasmodium vivax flavodoxin domain containing protein 0.0025 0.0076 0.0064
Loa Loa (eye worm) hypothetical protein 0.0116 0.0909 0.1139
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0158 0.1298 0.1627
Brugia malayi putative neuropeptide receptor NPR1 0.0158 0.1298 0.1521
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0029 0.0021
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1109 1 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0229 0.0269
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0229 0.0278
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0032 0.014 0.0145
Schistosoma mansoni neuropeptide receptor 0.0158 0.1298 0.1619
Echinococcus multilocularis neuropeptide receptor A26 0.0398 0.3495 0.349
Echinococcus multilocularis g protein coupled receptor 0.0158 0.1298 0.1292
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0043 0.0044
Onchocerca volvulus 0.0047 0.0282 0.107
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0889 0.7981 1
Echinococcus multilocularis musashi 0.002 0.0034 0.0026
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0019 0.0022 0.0015
Echinococcus granulosus somatostatin receptor 0.0158 0.1298 0.1292
Loa Loa (eye worm) hypothetical protein 0.0047 0.0282 0.0353
Trichomonas vaginalis sulfite reductase, putative 0.0028 0.0105 0.0113
Loa Loa (eye worm) hypothetical protein 0.0634 0.5649 0.7078
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0028 0.0105 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0019 0.0027 0.0019
Onchocerca volvulus 0.0158 0.1298 0.5373
Echinococcus granulosus rhodopsin orphan GPCR 0.0158 0.1298 0.1292
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0229 0.0222
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0094 0.0712 0.0892
Loa Loa (eye worm) hypothetical protein 0.0024 0.0068 0.0086
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.021 0.177 0.2073
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0061 0.0408 0.0501
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0158 0.1298 0.1619
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.002 0.0029 0.0027
Echinococcus multilocularis rhodopsin orphan GPCR 0.0158 0.1298 0.1292
Loa Loa (eye worm) hypothetical protein 0.0158 0.1298 0.1627
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0019 0.0027 0.0031
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.021 0.177 0.2217
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0423 0.372 0.4357
Schistosoma mansoni nuclear hormone receptor 0.002 0.0029 0.0027
Schistosoma mansoni sodium/chloride dependent transporter 0.0278 0.2391 0.2989
Loa Loa (eye worm) G-protein coupled receptor 0.0158 0.1298 0.1627
Echinococcus granulosus beta LACTamase domain containing family member 0.0024 0.0068 0.0061
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0037
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0158 0.1298 0.1292
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.021 0.177 0.1763
Onchocerca volvulus 0.0158 0.1298 0.5373
Schistosoma mansoni neuropeptide receptor 0.0158 0.1298 0.1619
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0094 0.0712 0.0704
Echinococcus granulosus snurportin 1 0.0204 0.1713 0.1707
Loa Loa (eye worm) hypothetical protein 0.0158 0.1298 0.1627
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.021 0.177 0.1763
Toxoplasma gondii hypothetical protein 0.0047 0.0282 0.0323
Schistosoma mansoni amine GPCR 0.0158 0.1298 0.1619
Trypanosoma brucei C-8 sterol isomerase, putative 0.0423 0.372 0.4661
Loa Loa (eye worm) hypothetical protein 0.0158 0.1298 0.1627
Echinococcus granulosus rhodopsin orphan GPCR 0.0158 0.1298 0.1292
Echinococcus multilocularis neuropeptides capa receptor 0.0158 0.1298 0.1292
Echinococcus granulosus lamin dm0 0.002 0.0034 0.0026
Schistosoma mansoni opsin-like receptor 0.0158 0.1298 0.1619
Echinococcus multilocularis rhodopsin orphan GPCR 0.0158 0.1298 0.1292
Brugia malayi RNA, U transporter 1 0.0054 0.0347 0.0406
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.021 0.177 0.1763
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0229 0.0222
Loa Loa (eye worm) hypothetical protein 0.0024 0.0068 0.0086
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0158 0.1298 0.1521
Loa Loa (eye worm) hypothetical protein 0.0498 0.4406 0.5521
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.021 0.177 0.2217
Loa Loa (eye worm) neuropeptide F receptor 0.0158 0.1298 0.1627
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.021 0.177 0.2073
Schistosoma mansoni cytochrome P450 reductase 0.0028 0.0105 0.0122
Loa Loa (eye worm) hypothetical protein 0.021 0.177 0.2217
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.021 0.177 0.2217
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0889 0.7981 0.798
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0889 0.7981 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.0712 0.0892
Loa Loa (eye worm) melatonin receptor type 1A 0.0158 0.1298 0.1627
Echinococcus multilocularis glycine receptor subunit alpha 1 0.021 0.177 0.1763
Brugia malayi nuclear receptor NHR-88 0.0041 0.0229 0.0269
Loa Loa (eye worm) hypothetical protein 0.021 0.177 0.2217
Loa Loa (eye worm) hypothetical protein 0.0423 0.372 0.4661
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0037
Schistosoma mansoni intermediate filament proteins 0.002 0.0034 0.0033
Loa Loa (eye worm) hypothetical protein 0.021 0.177 0.2217
Echinococcus multilocularis neuropeptide Y receptor 0.0158 0.1298 0.1292
Loa Loa (eye worm) hypothetical protein 0.0158 0.1298 0.1627
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0158 0.1298 0.1619
Echinococcus granulosus thyroid hormone receptor alpha 0.002 0.0029 0.0021
Echinococcus granulosus fmrfamide receptor 0.0158 0.1298 0.1292
Schistosoma mansoni nAChR subunit 0.021 0.177 0.221
Onchocerca volvulus 0.0158 0.1298 0.5373
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.021 0.177 0.2073
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.021 0.177 0.1763
Echinococcus multilocularis beta LACTamase domain containing family member 0.0024 0.0068 0.0061
Loa Loa (eye worm) hypothetical protein 0.0158 0.1298 0.1627
Loa Loa (eye worm) hypothetical protein 0.0094 0.0712 0.0892
Echinococcus multilocularis g-protein coupled receptor 0.0158 0.1298 0.1292
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0889 0.7981 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0158 0.1298 0.1619
Loa Loa (eye worm) TYRA-2 protein 0.0158 0.1298 0.1627
Loa Loa (eye worm) nuclear receptor nhr-7B 0.002 0.0029 0.0037
Schistosoma mansoni nAChR subunit 0.021 0.177 0.221
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.021 0.177 0.1763
Onchocerca volvulus 0.0158 0.1298 0.5373
Loa Loa (eye worm) hypothetical protein 0.0769 0.6888 0.8631
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.021 0.177 0.2073
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0047 0.0282 1
Brugia malayi beta-lactamase family protein 0.0024 0.0068 0.008
Brugia malayi hypothetical protein 0.0158 0.1298 0.1521
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.021 0.177 0.221
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0029 0.012 0.014
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0051 0.0043
Brugia malayi orphan nuclear receptor NR2E1 0.002 0.0029 0.0034
Onchocerca volvulus 0.0158 0.1298 0.5373
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0031
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.021 0.177 0.1763
Echinococcus granulosus rhodopsin orphan GPCR 0.0158 0.1298 0.1292
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0037
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.021 0.177 0.2217
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0037
Brugia malayi hypothetical protein 0.0158 0.1298 0.1521
Entamoeba histolytica acetyltransferase, GNAT family 0.0029 0.0116 0.0118
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.021 0.177 0.221
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0229 0.0269
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.021 0.177 0.2073
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0158 0.1298 0.1619
Schistosoma mansoni nuclear receptor 0.002 0.0029 0.0027
Brugia malayi ecdysteroid receptor 0.0041 0.0229 0.0269
Loa Loa (eye worm) hypothetical protein 0.0158 0.1298 0.1627
Onchocerca volvulus 0.0158 0.1298 0.5373
Echinococcus granulosus g protein coupled receptor 0.0158 0.1298 0.1292
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0028 0.0105 0.0132
Loa Loa (eye worm) hypothetical protein 0.0158 0.1298 0.1627
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0029 0.0021
Trichomonas vaginalis esterase, putative 0.0024 0.0068 0.0067
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0047 0.0282 0.0323
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0037
Loa Loa (eye worm) hypothetical protein 0.0041 0.0229 0.0287
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0047 0.0282 0.0344
Schistosoma mansoni importin beta-1 0.0019 0.0025 0.0022
Onchocerca volvulus 0.021 0.177 0.7369
Trypanosoma cruzi p450 reductase, putative 0.0028 0.0105 0.0132
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0889 0.7981 1
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0028 0.0105 0.0132
Brugia malayi Nuclear hormone receptor E75 0.002 0.0029 0.0034
Echinococcus granulosus g-protein coupled receptor 0.0158 0.1298 0.1292
Trichomonas vaginalis set domain proteins, putative 0.0124 0.0981 0.1213
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0229 0.0269
Loa Loa (eye worm) hypothetical protein 0.0158 0.1298 0.1627
Loa Loa (eye worm) hypothetical protein 0.0094 0.0712 0.0892
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0889 0.7981 0.798
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.021 0.177 0.1763
Onchocerca volvulus 0.0094 0.0712 0.2889
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0158 0.1298 0.1292
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0047 0.0282 0.0344
Schistosoma mansoni nAChR subunit 0.0094 0.0712 0.0883
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0024 0.0068 0.6507
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.021 0.177 0.2073
Onchocerca volvulus 0.0158 0.1298 0.5373
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0047 0.0282 0.0344
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0158 0.1298 0.1619
Onchocerca volvulus 0.0024 0.0068 0.0166
Onchocerca volvulus 0.0116 0.0909 0.3724
Echinococcus multilocularis sodium and chloride dependent glycine 0.0047 0.0282 0.0274
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0158 0.1298 0.1619
Echinococcus multilocularis allatostatin A receptor 0.0158 0.1298 0.1292
Loa Loa (eye worm) hypothetical protein 0.0047 0.0282 0.0353
Echinococcus multilocularis sodium and chloride dependent glycine 0.0047 0.0282 0.0274
Schistosoma mansoni hypothetical protein 0.0204 0.1713 0.2139
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0094 0.0712 0.0704
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0229 0.0269
Treponema pallidum sodium- and chloride- dependent transporter 0.0278 0.2391 0.5
Brugia malayi Cation transporter family protein 0.021 0.177 0.2073
Loa Loa (eye worm) solute carrier family 6 member 4 0.0278 0.2391 0.2996
Schistosoma mansoni neurotransmitter gated ion channel 0.0116 0.0909 0.113
Leishmania major hypothetical protein, conserved 0.0024 0.0068 0.0086
Echinococcus granulosus histone acetyltransferase KAT2B 0.0105 0.0809 0.0801
Schistosoma mansoni biogenic amine (5HT) receptor 0.059 0.5254 0.6579
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0026 0.0087 0.0079
Schistosoma mansoni sodium-dependent amino acid transporter 0.0047 0.0282 0.0344
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0029 0.0021
Brugia malayi hypothetical protein 0.002 0.0029 0.0034
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0229 0.0222
Brugia malayi acetyltransferase, GNAT family protein 0.0108 0.0836 0.0979
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0029 0.012 0.0112
Echinococcus granulosus serotonin transporter 0.0278 0.2391 0.2385
Schistosoma mansoni biogenic amine receptor 0.0158 0.1298 0.1619
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0158 0.1298 0.1521
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.021 0.177 0.221
Echinococcus multilocularis glycine receptor subunit beta 0.021 0.177 0.1763
Loa Loa (eye worm) hypothetical protein 0.0022 0.0051 0.0063
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0094 0.0712 0.0704
Echinococcus granulosus neuropeptides capa receptor 0.0158 0.1298 0.1292
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0889 0.7981 1
Echinococcus multilocularis geminin 0.0088 0.066 0.0652
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0889 0.7981 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0229 0.0222
Schistosoma mansoni hypothetical protein 0.0158 0.1298 0.1619
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0229 0.0222
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0158 0.1298 0.1619
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.0229 0.0222
Schistosoma mansoni lamin 0.002 0.0034 0.0033
Loa Loa (eye worm) acetylcholine receptor protein 0.0094 0.0712 0.0892
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0047 0.0282 0.0344
Onchocerca volvulus 0.0158 0.1298 0.5373
Echinococcus multilocularis g protein coupled receptor 0.0158 0.1298 0.1292
Loa Loa (eye worm) hypothetical protein 0.021 0.177 0.2217
Echinococcus multilocularis rhodopsin orphan GPCR 0.0158 0.1298 0.1292
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0278 0.2391 0.2801
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0047 0.0282 0.0323
Loa Loa (eye worm) hypothetical protein 0.0158 0.1298 0.1627
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0229 0.0269
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0068 0.0055
Echinococcus granulosus tm gpcr rhodopsin 0.0753 0.6737 0.6734
Echinococcus granulosus serotonin receptor 0.0158 0.1298 0.1292
Loa Loa (eye worm) hypothetical protein 0.0278 0.2391 0.2996
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0094 0.0712 0.0892
Echinococcus multilocularis conserved hypothetical protein 0.0792 0.7102 0.71
Schistosoma mansoni nAChR subunit 0.021 0.177 0.221
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0158 0.1298 0.1292
Brugia malayi hypothetical protein 0.0158 0.1298 0.1521
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0029 0.012 0.0112
Echinococcus multilocularis somatostatin receptor 0.0158 0.1298 0.1292
Loa Loa (eye worm) hypothetical protein 0.0022 0.0051 0.0063
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.021 0.177 0.2217
Loa Loa (eye worm) hypothetical protein 0.0675 0.6027 0.7552
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0047 0.0282 0.033
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.021 0.177 0.2073
Echinococcus granulosus histone acetyltransferase KAT2B 0.0032 0.014 0.0133
Giardia lamblia Histone acetyltransferase GCN5 0.0029 0.0116 0.9207
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0116 0.0909 0.1064
Echinococcus granulosus sodium and chloride dependent glycine 0.0047 0.0282 0.0274
Brugia malayi nuclear receptor RXR 0.002 0.0029 0.0034
Schistosoma mansoni nuclear receptor nhr-48 0.002 0.0029 0.0027
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0028 0.0105 0.0132
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0889 0.7981 1
Mycobacterium ulcerans hypothetical protein 0.0024 0.0068 0.6507
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0047 0.0282 0.0344
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0158 0.1298 0.1627
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0047 0.0282 0.0353
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0029 0.0021
Brugia malayi hypothetical protein 0.0047 0.0282 0.033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0229 0.0287
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0051 0.0059
Brugia malayi excitatory GABA receptor EXP-1A 0.021 0.177 0.2073
Echinococcus granulosus neuropeptide FF receptor 2 0.0158 0.1298 0.1292
Trypanosoma brucei importin beta-1 subunit, putative 0.0019 0.0025 0.0031
Onchocerca volvulus 0.0158 0.1298 0.5373
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0061 0.0408 0.0477
Schistosoma mansoni neuropeptide receptor 0.0158 0.1298 0.1619
Echinococcus granulosus glycine receptor subunit alpha 1 0.021 0.177 0.1763
Brugia malayi hypothetical protein 0.0158 0.1298 0.1521
Loa Loa (eye worm) hypothetical protein 0.0158 0.1298 0.1627
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0116 0.0909 0.1064
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0094 0.0712 0.0833
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.021 0.177 0.2073
Brugia malayi hypothetical protein 0.002 0.0029 0.0034
Brugia malayi Nuclear hormone receptor E75 0.002 0.0029 0.0034
Loa Loa (eye worm) hypothetical protein 0.0368 0.3215 0.4028
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0043
Loa Loa (eye worm) hypothetical protein 0.0158 0.1298 0.1627
Echinococcus multilocularis G-protein coupled receptor, putative 0.0158 0.1298 0.1292
Brugia malayi Dopamine receptor protein 1 0.0634 0.5649 0.6616
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0229 0.0269
Mycobacterium ulcerans esterase/lipase LipP 0.0024 0.0068 0.6507
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0094 0.0712 0.0833
Loa Loa (eye worm) hypothetical protein 0.0094 0.0712 0.0892
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.0229 0.0269
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0029 0.012 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.002 0.0034 0.0043
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0889 0.7981 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0158 0.1298 0.1619
Brugia malayi beta-lactamase 0.0024 0.0068 0.008
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0229 0.0222
Echinococcus multilocularis orexin receptor type 2 0.0158 0.1298 0.1292
Loa Loa (eye worm) hypothetical protein 0.0041 0.0229 0.0287
Loa Loa (eye worm) hypothetical protein 0.021 0.177 0.2217
Echinococcus granulosus neuropeptide receptor 0.0158 0.1298 0.1292
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0047 0.0282 0.033
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0116 0.0909 0.113
Brugia malayi intermediate filament protein 0.002 0.0034 0.004
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0047 0.0282 0.033
Echinococcus multilocularis neuropeptides capa receptor 0.0158 0.1298 0.1292
Echinococcus granulosus dro:myosuppressin receptor 0.0158 0.1298 0.1292
Echinococcus multilocularis transcription factor Dp 1 0.0035 0.0173 0.0165
Schistosoma mansoni coup transcription factor 0.0041 0.0229 0.0278
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0024 0.0068 0.0076
Schistosoma mansoni sodium/chloride dependent transporter 0.0047 0.0282 0.0344
Echinococcus multilocularis g protein coupled receptor 0.0158 0.1298 0.1292
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.021 0.177 0.1763
Loa Loa (eye worm) hypothetical protein 0.0158 0.1298 0.1627
Loa Loa (eye worm) hypothetical protein 0.0158 0.1298 0.1627
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0032 0.014 0.0145
Brugia malayi beta-lactamase family protein 0.0024 0.0068 0.008
Loa Loa (eye worm) hypothetical protein 0.0024 0.0068 0.0086
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.021 0.177 0.1763
Onchocerca volvulus 0.0024 0.0068 0.0166
Echinococcus multilocularis thyroid hormone receptor alpha 0.0107 0.083 0.0823
Loa Loa (eye worm) hypothetical protein 0.0047 0.0282 0.0353
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0051 0.0054
Echinococcus multilocularis snurportin 1 0.0204 0.1713 0.1707
Echinococcus multilocularis serotonin transporter 0.0278 0.2391 0.2385
Trichomonas vaginalis D-aminoacylase, putative 0.0024 0.0068 0.0067
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0061 0.0408 0.04
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0229 0.0222
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0024 0.0068 0.0086
Loa Loa (eye worm) hypothetical protein 0.021 0.177 0.2217
Echinococcus granulosus transcription factor Dp 1 0.0035 0.0173 0.0165
Mycobacterium ulcerans beta-lactamase 0.0024 0.0068 0.6507
Schistosoma mansoni neuropeptide F-like receptor 0.0158 0.1298 0.1619
Echinococcus multilocularis lamin dm0 0.002 0.0034 0.0026
Schistosoma mansoni biogenic amine (5HT) receptor 0.0368 0.3215 0.4022
Trichomonas vaginalis D-aminoacylase, putative 0.0024 0.0068 0.0067
Loa Loa (eye worm) hypothetical protein 0.0278 0.2391 0.2996
Schistosoma mansoni amine GPCR 0.0158 0.1298 0.1619
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0004
Onchocerca volvulus 0.0158 0.1298 0.5373
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0061 0.0408 0.0511
Onchocerca volvulus 0.021 0.177 0.7369
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0031 0.0131 0.0134
Loa Loa (eye worm) hypothetical protein 0.0022 0.0051 0.0063
Loa Loa (eye worm) hypothetical protein 0.021 0.177 0.2217
Echinococcus multilocularis rhodopsin orphan GPCR 0.0158 0.1298 0.1292
Loa Loa (eye worm) hypothetical protein 0.0498 0.4406 0.5521
Brugia malayi GnHR receptor homolog 0.0158 0.1298 0.1521
Echinococcus granulosus biogenic amine 5HT receptor 0.0368 0.3215 0.321
Loa Loa (eye worm) hypothetical protein 0.0158 0.1298 0.1627
Brugia malayi G-protein coupled receptor 0.0158 0.1298 0.1521
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0032 0.014 0.0157
Brugia malayi Dopamine receptor protein 2 0.0158 0.1298 0.1521
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0037
Schistosoma mansoni hypothetical protein 0.0158 0.1298 0.1619
Brugia malayi Serotonin receptor 0.0949 0.8538 1
Echinococcus granulosus biogenic amine 5HT receptor 0.059 0.5254 0.525
Loa Loa (eye worm) hypothetical protein 0.0278 0.2391 0.2996
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0108 0.0836 0.0829
Loa Loa (eye worm) hypothetical protein 0.021 0.177 0.2217
Onchocerca volvulus 0.0047 0.0282 0.107
Schistosoma mansoni acetylcholine receptor subunit beta 0.0094 0.0712 0.0883
Loa Loa (eye worm) FAD binding domain-containing protein 0.0017 0.0008 0.001
Schistosoma mansoni neurotransmitter gated ion channel 0.0094 0.0712 0.0883
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0229 0.0287
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0047 0.0282 0.033
Onchocerca volvulus 0.0041 0.0229 0.0847
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0158 0.1298 0.1292
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0158 0.1298 0.1619
Brugia malayi nuclear receptor NHR-67 0.002 0.0029 0.0034
Onchocerca volvulus 0.0158 0.1298 0.5373
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0229 0.0278
Echinococcus multilocularis nAChR subunit 0.0116 0.0909 0.0902
Schistosoma mansoni nAChR subunit 0.021 0.177 0.221
Brugia malayi hypothetical protein 0.0094 0.0712 0.0833
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0158 0.1298 0.1292
Loa Loa (eye worm) hypothetical protein 0.021 0.177 0.2217
Loa Loa (eye worm) hypothetical protein 0.0158 0.1298 0.1627
Loa Loa (eye worm) beta-lactamase 0.0024 0.0068 0.0086
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0094 0.0712 0.0833
Echinococcus multilocularis lamin 0.002 0.0034 0.0026
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0116 0.0909 0.1064
Schistosoma mansoni neurotransmitter gated ion channel 0.0094 0.0712 0.0883
Loa Loa (eye worm) hypothetical protein 0.0094 0.0712 0.0892
Onchocerca volvulus 0.0158 0.1298 0.5373
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0061 0.0408 0.0484
Brugia malayi Cation transporter family protein 0.021 0.177 0.2073
Schistosoma mansoni lamin 0.002 0.0034 0.0033
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0229 0.0287
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0047 0.0282 0.0344
Echinococcus granulosus nuclear receptor nhr 48 0.002 0.0029 0.0021
Loa Loa (eye worm) serotonin transporter b 0.0278 0.2391 0.2996
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0889 0.7981 1
Schistosoma mansoni transcription factor LCR-F1 0.0019 0.0022 0.0018
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0109 0.0844 0.1058
Brugia malayi G-protein coupled receptor 0.0158 0.1298 0.1521
Schistosoma mansoni nAChR subunit 0.021 0.177 0.221
Brugia malayi hypothetical protein 0.0158 0.1298 0.1521
Brugia malayi Cation transporter family protein 0.021 0.177 0.2073
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0047 0.0282 0.0274
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0029 0.0021
Loa Loa (eye worm) hypothetical protein 0.0041 0.0229 0.0287
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0158 0.1298 0.1627
Echinococcus granulosus rhodopsin orphan GPCR 0.0158 0.1298 0.1292
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0158 0.1298 0.1619
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0051 0.0043
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.021 0.177 0.2073
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0061 0.0408 0.0511
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0028 0.0105 0.0097
Loa Loa (eye worm) hypothetical protein 0.021 0.177 0.2217
Plasmodium falciparum amino acid transporter, putative 0.0047 0.0282 0.0323
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0158 0.1298 0.1619
Onchocerca volvulus 0.021 0.177 0.7369
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0152 0.1242 1
Echinococcus granulosus neuropeptide receptor A26 0.0398 0.3495 0.349
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0229 0.0222
Loa Loa (eye worm) hypothetical protein 0.021 0.177 0.2217
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0158 0.1298 0.1292
Echinococcus granulosus 7tm_1 domain containing protein 0.0158 0.1298 0.1292
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0229 0.0847
Loa Loa (eye worm) hypothetical protein 0.0041 0.0229 0.0287
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0029 0.012 0.0112
Onchocerca volvulus 0.002 0.0034 0.002
Loa Loa (eye worm) hypothetical protein 0.0116 0.0909 0.1139
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0094 0.0712 0.0704
Brugia malayi follicle stimulating hormone receptor 0.0158 0.1298 0.1521
Loa Loa (eye worm) hypothetical protein 0.0024 0.0068 0.0086
Schistosoma mansoni nuclear hormone receptor 0.002 0.0029 0.0027
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0423 0.372 0.4661
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0028 0.0105 0.0132
Echinococcus granulosus sodium and chloride dependent glycine 0.0047 0.0282 0.0274
Echinococcus granulosus glycine receptor subunit alpha 1 0.021 0.177 0.1763
Onchocerca volvulus Neuropeptide F receptor homolog 0.0158 0.1298 0.5373
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0047 0.0282 0.0274
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.021 0.177 0.1763
Echinococcus multilocularis rhodopsin orphan GPCR 0.0158 0.1298 0.1292
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0066 0.0452 0.0444
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0158 0.1298 0.1627
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0229 0.0287
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0047 0.0282 0.0353
Trypanosoma brucei importin beta-1 subunit, putative 0.0019 0.0025 0.0031
Loa Loa (eye worm) hypothetical protein 0.021 0.177 0.2217
Brugia malayi G protein-coupled receptor 0.0158 0.1298 0.1521
Brugia malayi FAD binding domain containing protein 0.0028 0.0105 0.0123
Loa Loa (eye worm) hypothetical protein 0.0028 0.0105 0.0132
Brugia malayi ORL1-like opioid receptor 0.0158 0.1298 0.1521
Loa Loa (eye worm) hypothetical protein 0.0158 0.1298 0.1627
Schistosoma mansoni histamine h1 receptor 0.0158 0.1298 0.1619
Brugia malayi hypothetical protein 0.0094 0.0712 0.0833
Onchocerca volvulus 0.021 0.177 0.7369
Loa Loa (eye worm) hypothetical protein 0.0216 0.1828 0.2291
Loa Loa (eye worm) hypothetical protein 0.0158 0.1298 0.1627
Schistosoma mansoni hypothetical protein 0.0158 0.1298 0.1619
Schistosoma mansoni amine GPCR 0.0823 0.7385 0.9253
Brugia malayi hypothetical protein 0.0094 0.0712 0.0833
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0158 0.1298 0.1619
Loa Loa (eye worm) hypothetical protein 0.0094 0.0712 0.0892
Loa Loa (eye worm) hypothetical protein 0.0158 0.1298 0.1627
Echinococcus granulosus g protein coupled receptor 0.0158 0.1298 0.1292
Echinococcus multilocularis neuropeptide receptor 0.0158 0.1298 0.1292
Trichomonas vaginalis penicillin-binding protein, putative 0.0024 0.0068 0.0067
Echinococcus granulosus G protein coupled receptor 139 0.0158 0.1298 0.1292
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0229 0.0287
Brugia malayi nuclear hormone receptor family member nhr-6 0.002 0.0029 0.0034
Schistosoma mansoni nAChR subunit 0.021 0.177 0.221
Onchocerca volvulus 0.0047 0.0282 0.107
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0158 0.1298 0.1619
Plasmodium vivax hypothetical protein, conserved 0.0047 0.0282 0.0323
Entamoeba histolytica hypothetical protein 0.0116 0.0909 0.1114
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0229 0.0222
Loa Loa (eye worm) intermediate filament protein 0.002 0.0034 0.0043
Brugia malayi tailless protein 0.002 0.0029 0.0034
Schistosoma mansoni nAChR subunit 0.0094 0.0712 0.0883
Echinococcus granulosus geminin 0.0088 0.066 0.0652
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0061 0.0408 0.0511
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0158 0.1298 0.1292
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0229 0.0287
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0158 0.1298 0.1292
Trichomonas vaginalis D-aminoacylase, putative 0.0024 0.0068 0.0067
Loa Loa (eye worm) hypothetical protein 0.0158 0.1298 0.1627
Echinococcus granulosus orexin receptor type 2 0.0158 0.1298 0.1292
Onchocerca volvulus 0.0116 0.0909 0.3724
Brugia malayi hypothetical protein 0.0094 0.0712 0.0833
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0889 0.7981 0.9348
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0047 0.0282 0.0344
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0158 0.1298 0.1619
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0158 0.1298 0.1619
Brugia malayi conserved hypotetical protein 0.002 0.0029 0.0034
Plasmodium falciparum nitric oxide synthase, putative 0.0028 0.0105 0.0101
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0037
Loa Loa (eye worm) hypothetical protein 0.0158 0.1298 0.1627
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.021 0.177 0.1763
Loa Loa (eye worm) hypothetical protein 0.0094 0.0712 0.0892
Loa Loa (eye worm) hypothetical protein 0.0158 0.1298 0.1627
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0047 0.0282 0.0274
Plasmodium falciparum transporter, putative 0.0047 0.0282 0.0323
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0158 0.1298 0.1619
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0028 0.0105 0.0097
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0068 0.5
Brugia malayi Serotonin receptor 0.0158 0.1298 0.1521
Schistosoma mansoni hypothetical protein 0.0088 0.066 0.0817
Echinococcus multilocularis glycine receptor subunit alpha 1 0.021 0.177 0.1763
Brugia malayi hypothetical protein 0.0158 0.1298 0.1521
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0158 0.1298 0.1292
Loa Loa (eye worm) hypothetical protein 0.0158 0.1298 0.1627
Brugia malayi Tachykinin-like peptides receptor 99D 0.0158 0.1298 0.1521
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0051 0.0059
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0122 0.0968 0.0961
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0158 0.1298 0.1292
Brugia malayi neuropeptide F receptor 0.0158 0.1298 0.1521
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0094 0.0712 0.0833
Echinococcus multilocularis serotonin receptor 0.0368 0.3215 0.321
Echinococcus granulosus neuropeptides capa receptor 0.0158 0.1298 0.1292
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.0229 0.0269
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0094 0.0712 0.0833
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0158 0.1298 0.1292
Leishmania major p450 reductase, putative 0.0028 0.0105 0.0132
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.002 0.0029 0.0021
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.021 0.177 0.2073
Schistosoma mansoni retinoic acid receptor RXR 0.0144 0.1168 0.1456
Loa Loa (eye worm) hypothetical protein 0.0368 0.3215 0.4028
Echinococcus multilocularis biogenic amine (5HT) receptor 0.059 0.5254 0.525
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.021 0.177 0.1763
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0024 0.0068 0.0076
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0024 0.0068 0.008
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.021 0.177 0.221
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0498 0.4406 0.5516
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0229 0.0269
Echinococcus multilocularis glycine receptor subunit alpha 1 0.021 0.177 0.1763
Echinococcus granulosus rhodopsin orphan GPCR 0.0158 0.1298 0.1292
Echinococcus granulosus glycine receptor subunit beta 0.021 0.177 0.1763
Echinococcus granulosus importin subunit beta 1 0.0019 0.0025 0.0017
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0158 0.1298 0.1292
Loa Loa (eye worm) hypothetical protein 0.0116 0.0909 0.1139
Loa Loa (eye worm) acetyltransferase 0.0108 0.0836 0.1048
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0229 0.0287
Schistosoma mansoni amine GPCR 0.0158 0.1298 0.1619
Loa Loa (eye worm) hypothetical protein 0.0158 0.1298 0.1627
Loa Loa (eye worm) hypothetical protein 0.0094 0.0712 0.0892
Onchocerca volvulus 0.0124 0.0981 0.4031
Schistosoma mansoni acetylcholine receptor-related 0.0094 0.0712 0.0883
Schistosoma mansoni thyroid hormone receptor 0.0107 0.083 0.1032
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.021 0.177 0.1763
Brugia malayi Intermediate filament tail domain containing protein 0.002 0.0034 0.004
Loa Loa (eye worm) hypothetical protein 0.0158 0.1298 0.1627
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0158 0.1298 0.1292
Echinococcus granulosus rhodopsin orphan GPCR 0.0158 0.1298 0.1292
Brugia malayi hypothetical protein 0.0094 0.0712 0.0833
Echinococcus granulosus tm gpcr rhodopsin 0.0158 0.1298 0.1292
Schistosoma mansoni zinc finger protein 0.002 0.0029 0.0027
Loa Loa (eye worm) hypothetical protein 0.0047 0.0282 0.0353
Brugia malayi RE15519p 0.0158 0.1298 0.1521
Schistosoma mansoni biogenic amine receptor 0.0158 0.1298 0.1619
Onchocerca volvulus 0.0024 0.0068 0.0166
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0229 0.0269
Loa Loa (eye worm) neuropeptide F receptor 0.0158 0.1298 0.1627
Brugia malayi hypothetical protein 0.0158 0.1298 0.1521
Echinococcus granulosus peptide allatostatin:somatostatin 0.0158 0.1298 0.1292
Loa Loa (eye worm) hypothetical protein 0.0116 0.0909 0.1139
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0028 0.0105 0.0132
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0158 0.1298 0.1521
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0229 0.0269
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0094 0.0712 0.0704
Loa Loa (eye worm) hypothetical protein 0.0024 0.0068 0.0086
Echinococcus multilocularis glycine receptor subunit beta 0.021 0.177 0.1763
Echinococcus granulosus lamin 0.002 0.0034 0.0026
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0204 0.1713 0.2147
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0043 0.0044
Echinococcus granulosus nAChR subunit 0.0116 0.0909 0.0902
Loa Loa (eye worm) hypothetical protein 0.0634 0.5649 0.7078
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0229 0.0222
Echinococcus multilocularis neuropeptide FF receptor 2 0.0158 0.1298 0.1292
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0229 0.0269
Loa Loa (eye worm) hypothetical protein 0.0158 0.1298 0.1627
Loa Loa (eye worm) hypothetical protein 0.0158 0.1298 0.1627
Loa Loa (eye worm) hypothetical protein 0.0041 0.0229 0.0287
Echinococcus multilocularis G protein coupled receptor 139 0.0158 0.1298 0.1292
Loa Loa (eye worm) hypothetical protein 0.0116 0.0909 0.1139
Loa Loa (eye worm) hypothetical protein 0.021 0.177 0.2217
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0158 0.1298 0.1619
Loa Loa (eye worm) hypothetical protein 0.0116 0.0909 0.1139
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0026 0.0087 0.0079
Loa Loa (eye worm) LGC-31 protein 0.021 0.177 0.2217
Mycobacterium leprae Probable lipase LipE 0.0024 0.0068 0.5
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0108 0.0836 0.1039
Brugia malayi hypothetical protein 0.0158 0.1298 0.1521
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0037
Loa Loa (eye worm) hypothetical protein 0.0158 0.1298 0.1627
Loa Loa (eye worm) hypothetical protein 0.021 0.177 0.2217
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0019 0.0022 0.0015
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0068 0.0086
Loa Loa (eye worm) hypothetical protein 0.0634 0.5649 0.7078
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0032 0.014 0.0145
Loa Loa (eye worm) hypothetical protein 0.0041 0.0229 0.0287
Schistosoma mansoni adenoreceptor 0.0158 0.1298 0.1619
Loa Loa (eye worm) hypothetical protein 0.0094 0.0712 0.0892
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.021 0.177 0.1763
Brugia malayi hypothetical protein 0.0158 0.1298 0.1521
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0229 0.0278
Schistosoma mansoni opsin-like receptor 0.0158 0.1298 0.1619
Onchocerca volvulus 0.0158 0.1298 0.5373
Echinococcus multilocularis fmrfamide receptor 0.0158 0.1298 0.1292
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0037
Brugia malayi flavodoxin family protein 0.0028 0.0105 0.0123
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0068 0.0086
Schistosoma mansoni biogenic amine receptor 0.0158 0.1298 0.1619
Schistosoma mansoni neuropeptide F-like receptor 0.0158 0.1298 0.1619
Brugia malayi nuclear hormone receptor 0.002 0.0029 0.0034
Loa Loa (eye worm) FAD binding domain-containing protein 0.0028 0.0105 0.0132
Loa Loa (eye worm) hypothetical protein 0.021 0.177 0.2217
Loa Loa (eye worm) hypothetical protein 0.0022 0.0051 0.0063
Plasmodium falciparum histone acetyltransferase GCN5 0.0029 0.0116 0.0115
Brugia malayi Pre-SET motif family protein 0.0109 0.0844 0.0989
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0229 0.0278
Schistosoma mansoni hypothetical protein 0.0019 0.0022 0.0018
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0028 0.0105 0.0101
Echinococcus multilocularis dro:myosuppressin receptor 0.0158 0.1298 0.1292
Echinococcus multilocularis nAChR subunit 0.021 0.177 0.1763
Brugia malayi nuclear hormone receptor family member odr-7 0.002 0.0029 0.0034
Loa Loa (eye worm) hypothetical protein 0.0094 0.0712 0.0892
Onchocerca volvulus 0.0094 0.0712 0.2889
Loa Loa (eye worm) hypothetical protein 0.0158 0.1298 0.1627
Echinococcus multilocularis rhodopsin orphan GPCR 0.0158 0.1298 0.1292
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.021 0.177 0.2073
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0229 0.0222
Brugia malayi hypothetical protein 0.0022 0.0051 0.0059
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0889 0.7981 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0282 0.0353
Loa Loa (eye worm) GABA receptor subunit 0.0116 0.0909 0.1139
Schistosoma mansoni thyroid hormone receptor 0.0107 0.083 0.1032
Loa Loa (eye worm) hypothetical protein 0.0047 0.0282 0.0353
Brugia malayi nuclear hormone receptor 0.0041 0.0229 0.0269
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.002 0.0029 0.0021
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0158 0.1298 0.1619
Mycobacterium ulcerans lipase LipD 0.0024 0.0068 0.6507
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0158 0.1298 0.1619
Echinococcus granulosus 7TM GPCR rhodopsin 0.0158 0.1298 0.1292
Onchocerca volvulus 0.0158 0.1298 0.5373
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0028 0.0105 0.0132
Onchocerca volvulus 0.0158 0.1298 0.5373
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0158 0.1298 0.1292
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0158 0.1298 0.1619
Echinococcus granulosus nAChR subunit 0.021 0.177 0.1763
Echinococcus multilocularis nuclear receptor nhr 48 0.002 0.0029 0.0021
Schistosoma mansoni alpha-1 adrenergic receptor 0.0158 0.1298 0.1619
Brugia malayi AKH receptor 0.0158 0.1298 0.1521
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0158 0.1298 0.5373
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0229 0.0269
Brugia malayi hypothetical protein 0.0022 0.0051 0.0059
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0229 0.0222
Loa Loa (eye worm) hypothetical protein 0.0158 0.1298 0.1627
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0498 0.4406 0.516
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0019 0.0027 0.0033
Echinococcus multilocularis importin subunit beta 1 0.0019 0.0025 0.0017
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0889 0.7981 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0229 0.0222
Echinococcus granulosus neuropeptide Y receptor 0.0158 0.1298 0.1292
Toxoplasma gondii ABC1 family protein 0.0024 0.0068 0.0055
Schistosoma mansoni opsin-like receptor 0.0158 0.1298 0.1619
Onchocerca volvulus 0.0094 0.0712 0.2889
Loa Loa (eye worm) hypothetical protein 0.0041 0.0229 0.0287
Onchocerca volvulus 0.021 0.177 0.7369
Brugia malayi steroid hormone receptor 0.0041 0.0229 0.0269
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0047 0.0282 0.0274
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0229 0.0278
Loa Loa (eye worm) hypothetical protein 0.0158 0.1298 0.1627
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.021 0.177 0.2073
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0753 0.6737 0.6734
Loa Loa (eye worm) DR-78 0.002 0.0029 0.0037
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0037
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0051 0.0063
Brugia malayi sulfakinin receptor protein 0.0158 0.1298 0.1521
Echinococcus granulosus alpha 1A adrenergic receptor 0.0158 0.1298 0.1292
Onchocerca volvulus 0.021 0.177 0.7369
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0229 0.0222
Loa Loa (eye worm) hypothetical protein 0.0094 0.0712 0.0892
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0278 0.2391 0.2989
Loa Loa (eye worm) hypothetical protein 0.0094 0.0712 0.0892
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.021 0.177 0.2073
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0028 0.0105 0.0132
Loa Loa (eye worm) hypothetical protein 0.0022 0.0051 0.0063
Loa Loa (eye worm) nuclear hormone receptor 0.002 0.0029 0.0037
Toxoplasma gondii hypothetical protein 0.0047 0.0282 0.0323
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.021 0.177 0.2073
Echinococcus granulosus allatostatin A receptor 0.0158 0.1298 0.1292
Echinococcus multilocularis rhodopsin orphan GPCR 0.0158 0.1298 0.1292
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0051 0.0054
Onchocerca volvulus 0.0278 0.2391 1
Loa Loa (eye worm) hypothetical protein 0.0158 0.1298 0.1627
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0028 0.0105 0.0097
Echinococcus granulosus sex peptide receptor 0.0158 0.1298 0.1292
Brugia malayi G protein-coupled receptor F59B2.13 0.0158 0.1298 0.1521
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0028 0.0105 0.0097
Loa Loa (eye worm) hypothetical protein 0.0094 0.0712 0.0892
Loa Loa (eye worm) ACC-1 protein 0.021 0.177 0.2217
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0229 0.0278
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0037
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.021 0.177 0.2217
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0158 0.1298 0.1292
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0365 0.319 0.399
Echinococcus granulosus neuropeptide s receptor 0.0398 0.3495 0.349
Loa Loa (eye worm) hypothetical protein 0.0094 0.0712 0.0892
Onchocerca volvulus 0.0158 0.1298 0.5373
Loa Loa (eye worm) hypothetical protein 0.021 0.177 0.2217
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0047 0.0282 0.0274
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0094 0.0712 0.0833
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0026 0.0087 0.0102
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0144 0.1168 0.1161

Activities

Activity type Activity value Assay description Source Reference
clogP = 4.21 Calculated partition coefficient (clogP) ChEMBL. 7650681
Inhibition (binding) = 55.1 % In vitro inhibition of glucan synthase obtained from C. albicans at a concentration of 10 ug/mL. ChEMBL. 7650681
MIC (functional) = 80 ug ml-1 Antifungal activity against Candida albicans ChEMBL. 7650681

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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