Detailed information for compound 40836

Basic information

Technical information
  • TDR Targets ID: 40836
  • Name: 1-(2-methylpropylamino)-3-naphthalen-1-yloxyp ropan-2-ol
  • MW: 273.37 | Formula: C17H23NO2
  • H donors: 2 H acceptors: 1 LogP: 3.43 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(COc1cccc2c1cccc2)CNCC(C)C
  • InChi: 1S/C17H23NO2/c1-13(2)10-18-11-15(19)12-20-17-9-5-7-14-6-3-4-8-16(14)17/h3-9,13,15,18-19H,10-12H2,1-2H3
  • InChiKey: BBNJVDLLHMJGCV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(isobutylamino)-3-(1-naphthyloxy)propan-2-ol
  • 1-(isobutylamino)-3-(1-naphthalenyloxy)-2-propanol
  • 1-(2-methylpropylamino)-3-naphthalen-1-yloxy-propan-2-ol
  • 1-(isobutylamino)-3-(1-naphthoxy)propan-2-ol

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Cavia porcellus Beta-2 adrenergic receptor Starlite/ChEMBL References
Cavia porcellus Beta-1 adrenergic receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Beta-2 adrenergic receptor   418 aa 338 aa 19.5 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Beta-2 adrenergic receptor   418 aa 341 aa 25.2 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Beta-2 adrenergic receptor   418 aa 366 aa 33.1 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Beta-2 adrenergic receptor   418 aa 346 aa 33.5 %
Onchocerca volvulus Beta-2 adrenergic receptor   418 aa 352 aa 28.1 %
Schistosoma mansoni biogenic amine (5HT) receptor Beta-2 adrenergic receptor   418 aa 366 aa 31.7 %
Echinococcus multilocularis orexin receptor type 2 Beta-2 adrenergic receptor   418 aa 370 aa 24.3 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Beta-2 adrenergic receptor   418 aa 385 aa 33.5 %
Loa Loa (eye worm) hypothetical protein Beta-2 adrenergic receptor   418 aa 360 aa 23.3 %
Onchocerca volvulus Phospholipase d-related homolog Beta-2 adrenergic receptor   418 aa 385 aa 22.9 %
Echinococcus granulosus orexin receptor type 2 Beta-2 adrenergic receptor   418 aa 370 aa 24.1 %
Onchocerca volvulus Beta-2 adrenergic receptor   418 aa 348 aa 19.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0021 0.0156 0.0076
Echinococcus granulosus voltage dependent calcium channel subunit 0.0131 0.318 0.3645
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0026 0.0273 0.0213
Loa Loa (eye worm) G-protein coupled receptor 0.0021 0.0156 0.0065
Brugia malayi Cation transporter family protein 0.002 0.0109 0.0109
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0026 0.0273 0.0273
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.002 0.0109 0.0017
Onchocerca volvulus 0.0021 0.0156 0.0577
Echinococcus multilocularis G protein coupled receptor 139 0.0021 0.0156 0.0076
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0021 0.0156 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.0273 0.0273
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0238 0.0527
Schistosoma mansoni biogenic amine receptor 0.0021 0.0156 0.0065
Brugia malayi Melatonin receptor type 1A 0.0021 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.005 0.0956 0.0872
Schistosoma mansoni amine GPCR 0.0021 0.0156 0.0065
Onchocerca volvulus 0.0021 0.0156 0.0577
Echinococcus granulosus tm gpcr rhodopsin 0.0021 0.0156 0.0076
Echinococcus granulosus biogenic amine 5HT receptor 0.0168 0.4209 0.486
Schistosoma mansoni hypothetical protein 0.0021 0.0156 0.0065
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0026 0.0273 0.0213
Schistosoma mansoni opsin-like receptor 0.0021 0.0156 0.0065
Echinococcus granulosus neuropeptide receptor 0.0021 0.0156 0.0076
Schistosoma mansoni opsin-like receptor 0.0021 0.0156 0.0065
Onchocerca volvulus Neuropeptide F receptor homolog 0.0021 0.0156 0.0577
Brugia malayi Dopamine receptor protein 2 0.0021 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.002 0.0109 0.0017
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0021 0.0156 0.0065
Echinococcus multilocularis glycine receptor subunit beta 0.002 0.0109 0.002
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Onchocerca volvulus 0.0026 0.0273 0.2002
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.0109 0.002
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.0273 0.0273
Schistosoma mansoni biogenic amine receptor 0.0021 0.0156 0.0065
Brugia malayi excitatory GABA receptor EXP-1A 0.002 0.0109 0.0109
Echinococcus granulosus slit 2 protein 0.005 0.0956 0.102
Echinococcus granulosus pikachurin 0.005 0.0956 0.102
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0021 0.0156 0.0076
Brugia malayi steroid hormone receptor 0.0026 0.0273 0.0273
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0021 0.0156 0.0076
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0109 0.0109
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0021 0.0156 0.0076
Onchocerca volvulus 0.0021 0.0156 0.0577
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.0049 0.0927 1
Brugia malayi hypothetical protein 0.0021 0.0156 0.0156
Echinococcus multilocularis somatostatin receptor 0.0021 0.0156 0.0076
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0026 0.0273 0.2002
Echinococcus granulosus G protein coupled receptor 139 0.0021 0.0156 0.0076
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0525 0.0511
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0156 0.0076
Schistosoma mansoni nAChR subunit 0.002 0.0109 0.0017
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0026 0.0273 0.0213
Echinococcus multilocularis allatostatin A receptor 0.0021 0.0156 0.0076
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0021 0.0156 0.0076
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.2868 1
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.002 0.0109 0.002
Brugia malayi Serine carboxypeptidase F41C3.5 precursor 0.0049 0.0927 0.0927
Echinococcus multilocularis nAChR subunit 0.002 0.0109 0.002
Schistosoma mansoni steroid hormone receptor ad4bp 0.0026 0.0273 0.0183
Loa Loa (eye worm) hypothetical protein 0.002 0.0109 0.0017
Brugia malayi ORL1-like opioid receptor 0.0021 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Echinococcus granulosus dro:myosuppressin receptor 0.0021 0.0156 0.0076
Echinococcus multilocularis neuropeptide Y receptor 0.0021 0.0156 0.0076
Brugia malayi Kringle domain containing protein 0.0022 0.0178 0.0178
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.002 0.0109 0.002
Echinococcus multilocularis FTZ F1 alpha 0.0026 0.0273 0.0213
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Echinococcus granulosus g protein coupled receptor 0.0021 0.0156 0.0076
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0021 0.0156 0.0065
Echinococcus multilocularis G-protein coupled receptor, putative 0.0021 0.0156 0.0076
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0156 0.0076
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.002 0.0109 0.0109
Echinococcus multilocularis fmrfamide receptor 0.0021 0.0156 0.0076
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0156 0.0065
Echinococcus granulosus 7TM GPCR rhodopsin 0.0021 0.0156 0.0076
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Entamoeba histolytica hypothetical protein 0.0035 0.0525 1
Brugia malayi EGF-like domain containing protein 0.005 0.0956 0.0956
Schistosoma mansoni serine-rich repeat protein 0.0068 0.1433 0.1354
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0026 0.0273 0.0183
Echinococcus granulosus neuropeptide FF receptor 2 0.0021 0.0156 0.0076
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0026 0.0273 0.0183
Echinococcus granulosus FTZ F1 alpha 0.0026 0.0273 0.0213
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0021 0.0156 0.0577
Loa Loa (eye worm) hypothetical protein 0.0058 0.1166 0.1085
Echinococcus granulosus intermediate filament protein 0.0027 0.0315 0.0263
Echinococcus granulosus neuropeptide Y receptor 0.0021 0.0156 0.0076
Brugia malayi Dopamine receptor 0.0021 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0156 0.0076
Echinococcus multilocularis orexin receptor type 2 0.0021 0.0156 0.0076
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0109 0.0109
Brugia malayi hypothetical protein 0.0035 0.0525 0.0525
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0156 0.0076
Loa Loa (eye worm) hypothetical protein 0.005 0.0956 0.0872
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.002 0.0109 0.0109
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.0156 0.0065
Brugia malayi Dopamine receptor protein 1 0.0021 0.0156 0.0156
Brugia malayi sulfakinin receptor protein 0.0021 0.0156 0.0156
Brugia malayi GnHR receptor homolog 0.0021 0.0156 0.0156
Brugia malayi Tachykinin-like peptides receptor 99D 0.0021 0.0156 0.0156
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0021 0.0156 0.0065
Echinococcus granulosus g protein coupled receptor 0.0021 0.0156 0.0076
Onchocerca volvulus 0.0027 0.0315 0.2517
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0021 0.0156 0.0065
Brugia malayi intermediate filament protein 0.0027 0.0315 0.0315
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0021 0.0156 0.0065
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0156 0.0076
Schistosoma mansoni coup transcription factor 0.0026 0.0273 0.0183
Echinococcus granulosus peptide allatostatin:somatostatin 0.0021 0.0156 0.0076
Brugia malayi nuclear receptor NHR-88 0.0026 0.0273 0.0273
Echinococcus granulosus g-protein coupled receptor 0.0021 0.0156 0.0076
Loa Loa (eye worm) neuropeptide F receptor 0.0021 0.0156 0.0065
Brugia malayi ecdysteroid receptor 0.0026 0.0273 0.0273
Toxoplasma gondii aldehyde dehydrogenase 0.012 0.2868 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.2868 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0021 0.0156 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0026 0.0273 0.0273
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0026 0.0273 0.0213
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.002 0.0109 0.002
Loa Loa (eye worm) hypothetical protein 0.0022 0.0178 0.0087
Echinococcus granulosus alpha 1A adrenergic receptor 0.0021 0.0156 0.0076
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0021 0.0156 0.0076
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0026 0.0273 0.0183
Leishmania major hypothetical protein, conserved 0.0024 0.0238 0.0527
Schistosoma mansoni histamine h1 receptor 0.0021 0.0156 0.0065
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0156 0.0065
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Echinococcus granulosus orexin receptor type 2 0.0021 0.0156 0.0076
Schistosoma mansoni hypothetical protein 0.0021 0.0156 0.0065
Echinococcus multilocularis neuropeptide s receptor 0.0021 0.0156 0.0076
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.002 0.0109 0.002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0156 0.0065
Schistosoma mansoni nAChR subunit 0.002 0.0109 0.0017
Onchocerca volvulus 0.0022 0.0178 0.0841
Schistosoma mansoni neuropeptide receptor 0.0021 0.0156 0.0065
Schistosoma mansoni RAR-like nuclear receptor 0.0026 0.0273 0.0183
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Schistosoma mansoni amine GPCR 0.0021 0.0156 0.0065
Echinococcus multilocularis lamin dm0 0.0027 0.0315 0.0263
Echinococcus granulosus neurogenic locus notch protein 0.005 0.0956 0.102
Echinococcus multilocularis g protein coupled receptor 0.0021 0.0156 0.0076
Brugia malayi Cation transporter family protein 0.002 0.0109 0.0109
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0026 0.0273 0.0183
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0156 0.0076
Loa Loa (eye worm) hypothetical protein 0.002 0.0109 0.0017
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.005 0.0956 0.0956
Schistosoma mansoni growth hormone secretagogue receptor 0.0021 0.0156 0.0065
Toxoplasma gondii kringle domain-containing protein 0.0022 0.0178 0.0309
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0026 0.0273 0.0213
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0092 0.5
Loa Loa (eye worm) steroid hormone receptor 0.0026 0.0273 0.0183
Echinococcus granulosus serotonin receptor 0.0021 0.0156 0.0076
Onchocerca volvulus 0.0021 0.0156 0.0577
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.0109 0.002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0273 0.0183
Echinococcus multilocularis dro:myosuppressin receptor 0.0021 0.0156 0.0076
Echinococcus multilocularis ecdysone induced protein 78C 0.0026 0.0273 0.0213
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.0109 0.002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0273 0.0183
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0021 0.0156 0.0076
Onchocerca volvulus 0.0021 0.0156 0.0577
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0156 0.0076
Onchocerca volvulus 0.0021 0.0156 0.0577
Loa Loa (eye worm) hypothetical protein 0.002 0.0109 0.0017
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0238 1
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0315 0.0225
Brugia malayi hypothetical protein 0.0021 0.0156 0.0156
Brugia malayi hypothetical protein 0.0021 0.0156 0.0156
Echinococcus multilocularis tissue type plasminogen activator 0.0022 0.0178 0.0101
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0194 0.0103
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0021 0.0156 0.0065
Brugia malayi hypothetical protein 0.0021 0.0156 0.0156
Brugia malayi larval opioid receptor 0.0021 0.0156 0.0156
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0126 0.3033 0.2968
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.002 0.0109 0.0017
Loa Loa (eye worm) hypothetical protein 0.002 0.0109 0.0017
Echinococcus granulosus tm gpcr rhodopsin 0.0021 0.0156 0.0076
Loa Loa (eye worm) hypothetical protein 0.002 0.0109 0.0017
Brugia malayi hypothetical protein 0.0024 0.0238 0.0238
Loa Loa (eye worm) hypothetical protein 0.002 0.0109 0.0017
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.002 0.0109 0.0109
Echinococcus granulosus g protein coupled receptor 0.0021 0.0156 0.0076
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0109 0.0109
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.0049 0.0927 1
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0273 0.0273
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0021 0.0156 0.0076
Echinococcus granulosus lamin 0.0027 0.0315 0.0263
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0021 0.0156 0.0076
Schistosoma mansoni adenoreceptor 0.0021 0.0156 0.0065
Echinococcus granulosus neuropeptide s receptor 0.0021 0.0156 0.0076
Schistosoma mansoni hypothetical protein 0.0022 0.0178 0.0087
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.2919 0.3337
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0109 0.0109
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0238 0.175
Brugia malayi putative neuropeptide receptor 0.0021 0.0156 0.0156
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0022 0.0178 0.5874
Loa Loa (eye worm) hypothetical protein 0.005 0.0956 0.0872
Echinococcus granulosus lysosomal protective protein 0.0049 0.0927 0.0986
Brugia malayi G-protein coupled receptor 0.0021 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0026 0.0273 0.0183
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0315 0.0225
Loa Loa (eye worm) hypothetical protein 0.0026 0.0273 0.0183
Loa Loa (eye worm) hypothetical protein 0.002 0.0109 0.0017
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0156 0.0065
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.002 0.0109 0.002
Echinococcus granulosus 7tm_1 domain containing protein 0.0021 0.0156 0.0076
Loa Loa (eye worm) hypothetical protein 0.0026 0.0273 0.0183
Schistosoma mansoni nAChR subunit 0.002 0.0109 0.0017
Trypanosoma cruzi serine peptidase, Clan SC, Family S10, putative 0.0049 0.0927 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0273 0.0213
Leishmania major serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 0.0049 0.0927 0.3008
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.002 0.0109 0.002
Onchocerca volvulus 0.0021 0.0156 0.0577
Onchocerca volvulus 0.0021 0.0156 0.0577
Echinococcus granulosus tissue type plasminogen activator 0.0022 0.0178 0.0101
Echinococcus granulosus somatostatin receptor 0.0021 0.0156 0.0076
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Echinococcus multilocularis musashi 0.0027 0.0315 0.0263
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0156 0.0065
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0288 0.7512 0.8758
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0156 0.0065
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0238 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0092 0.5
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.002 0.0109 0.002
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.002 0.0109 0.0017
Brugia malayi Steroid receptor seven-up type 2 0.0026 0.0273 0.0273
Schistosoma mansoni neuropeptide receptor 0.0021 0.0156 0.0065
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0156 0.0076
Echinococcus multilocularis serotonin receptor 0.0168 0.4209 0.486
Echinococcus multilocularis lysosomal protective protein 0.0049 0.0927 0.0986
Onchocerca volvulus 0.0021 0.0156 0.0577
Schistosoma mansoni lamin 0.0027 0.0315 0.0225
Schistosoma mansoni neuropeptide F-like receptor 0.0021 0.0156 0.0065
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.002 0.0109 0.002
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0021 0.0156 0.0065
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.002 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.002 0.0109 0.0017
Echinococcus granulosus fmrfamide receptor 0.0021 0.0156 0.0076
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.002 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.002 0.0109 0.0017
Echinococcus granulosus glycine receptor subunit beta 0.002 0.0109 0.002
Loa Loa (eye worm) hypothetical protein 0.002 0.0109 0.0017
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0092 0.5
Echinococcus granulosus lamin dm0 0.0027 0.0315 0.0263
Echinococcus granulosus neuropeptides capa receptor 0.0021 0.0156 0.0076
Echinococcus multilocularis lamin 0.0027 0.0315 0.0263
Echinococcus granulosus tachykinin peptides receptor 99D 0.0021 0.0156 0.0076
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0156 0.0065
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.0156 0.0065
Onchocerca volvulus 0.0021 0.0156 0.0577
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0021 0.0156 0.0076
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Echinococcus multilocularis slit 2 protein 0.005 0.0956 0.102
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0063 0.1314 0.1233
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Echinococcus multilocularis fmrfamide receptor 0.0021 0.0156 0.0076
Onchocerca volvulus Uncharacterized serine carboxypeptidase homolog 0.0049 0.0927 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.012 0.2868 0.3277
Loa Loa (eye worm) hypothetical protein 0.0379 1 1
Onchocerca volvulus 0.0021 0.0156 0.0577
Loa Loa (eye worm) TYRA-2 protein 0.0021 0.0156 0.0065
Schistosoma mansoni family S10 non-peptidase homologue (S10 family) 0.0049 0.0927 0.0843
Brugia malayi G protein-coupled receptor F59B2.13 0.0021 0.0156 0.0156
Schistosoma mansoni nAChR subunit 0.002 0.0109 0.0017
Schistosoma mansoni amine GPCR 0.0021 0.0156 0.0065
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Schistosoma mansoni intermediate filament proteins 0.0027 0.0315 0.0225
Echinococcus multilocularis neuropeptide receptor A26 0.0021 0.0156 0.0076
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0026 0.0273 0.0183
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.2919 0.3337
Brugia malayi Cation transporter family protein 0.002 0.0109 0.0109
Schistosoma mansoni family S10 unassigned peptidase (S10 family) 0.0049 0.0927 0.0843
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0238 0.175
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.2868 1
Brugia malayi hypothetical protein 0.0021 0.0156 0.0156
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0021 0.0156 0.0065
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Schistosoma mansoni nAChR subunit 0.002 0.0109 0.0017
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0273 0.0213
Echinococcus granulosus voltage dependent calcium channel subunit 0.0288 0.7512 0.8758
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.002 0.0109 0.0109
Loa Loa (eye worm) melatonin receptor type 1A 0.0021 0.0156 0.0065
Echinococcus multilocularis tumor protein p63 0.0326 0.8564 1
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.002 0.0109 0.002
Loa Loa (eye worm) hypothetical protein 0.002 0.0109 0.0017
Schistosoma mansoni hypothetical protein 0.0068 0.1433 0.1354
Echinococcus granulosus biogenic amine 5HT receptor 0.0021 0.0156 0.0076
Echinococcus granulosus neuropeptide Y receptor 0.0021 0.0156 0.0076
Schistosoma mansoni alpha-1 adrenergic receptor 0.0021 0.0156 0.0065
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0026 0.0273 0.0183
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0021 0.0156 0.0076
Loa Loa (eye worm) hypothetical protein 0.0049 0.0927 0.0843
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0021 0.0156 0.0076
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.2868 0.2802
Echinococcus multilocularis neuropeptide receptor 0.0021 0.0156 0.0076
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0021 0.0156 0.0156
Schistosoma mansoni laminin gamma-3 chain 0.005 0.0956 0.0872
Echinococcus granulosus sex peptide receptor 0.0021 0.0156 0.0076
Loa Loa (eye worm) hypothetical protein 0.002 0.0109 0.0017
Onchocerca volvulus 0.0021 0.0156 0.0577
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.0109 0.002
Schistosoma mansoni biogenic amine receptor 0.0021 0.0156 0.0065
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Loa Loa (eye worm) hypothetical protein 0.0027 0.0315 0.0225
Echinococcus granulosus allatostatin A receptor 0.0021 0.0156 0.0076
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.002 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Brugia malayi neuropeptide F receptor 0.0021 0.0156 0.0156
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.0273 0.0273
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0092 0.0092
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.002 0.0109 0.0017
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.002 0.0109 0.0017
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Schistosoma mansoni thyroid hormone receptor 0.0147 0.3625 0.3566
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.2868 0.2802
Trypanosoma cruzi serine peptidase, Clan SC, Family S10, putative 0.0049 0.0927 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0021 0.0156 0.0076
Echinococcus multilocularis neuropeptide receptor 0.0021 0.0156 0.0076
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0156 0.0076
Echinococcus granulosus glycine receptor subunit beta 0.002 0.0109 0.002
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0026 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.002 0.0109 0.0017
Loa Loa (eye worm) G-protein coupled receptor 0.0021 0.0156 0.0065
Brugia malayi Cytochrome P450 family protein 0.0023 0.0194 0.0194
Loa Loa (eye worm) TK/ROR protein kinase 0.0022 0.0178 0.0087
Brugia malayi photoreceptor-specific nuclear receptor 0.0026 0.0273 0.0273
Onchocerca volvulus 0.0021 0.0156 0.0577
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0026 0.0273 0.0213
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0021 0.0156 0.0065
Schistosoma mansoni myosin xvIII 0.0021 0.0156 0.0065
Loa Loa (eye worm) hypothetical protein 0.0026 0.0273 0.0183
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0092 0.5
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0026 0.0273 0.0183
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0021 0.0156 0.0076
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0273 0.0213
Entamoeba histolytica hypothetical protein 0.0035 0.0525 1
Echinococcus multilocularis family S10 non peptidase ue (S10 family) 0.0044 0.0792 0.0827
Schistosoma mansoni neuropeptide receptor 0.0021 0.0156 0.0065
Schistosoma mansoni amine GPCR 0.0021 0.0156 0.0065
Loa Loa (eye worm) hypothetical protein 0.0168 0.4209 0.4156
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0156 0.0076
Entamoeba histolytica hypothetical protein 0.0035 0.0525 1
Schistosoma mansoni hypothetical protein 0.0122 0.2919 0.2853
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0021 0.0156 0.0076
Loa Loa (eye worm) hypothetical protein 0.0048 0.0884 0.0799
Brugia malayi hypothetical protein 0.0021 0.0156 0.0156
Plasmodium falciparum cysteine repeat modular protein 1 0.0022 0.0178 0.5874
Schistosoma mansoni neuropeptide f receptor 76f 0.0021 0.0156 0.0065
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0026 0.0273 0.0183
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0525 0.0511
Schistosoma mansoni cell polarity protein 0.005 0.0956 0.0872
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0238 0.175
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0021 0.0156 0.0076
Entamoeba histolytica hypothetical protein 0.0035 0.0525 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0026 0.0273 0.2002
Echinococcus multilocularis sex peptide receptor 0.0021 0.0156 0.0076
Schistosoma mansoni retinoic acid receptor RXR 0.0026 0.0273 0.0183
Loa Loa (eye worm) neuropeptide F receptor 0.0021 0.0156 0.0065
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0109 0.0109
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.002 0.0109 0.002
Schistosoma mansoni nuclear hormone receptor 0.0026 0.0273 0.0183
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0026 0.0273 0.0273
Brugia malayi laminin-like protein K08C7.3 precursor 0.005 0.0956 0.0956
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.0049 0.0927 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.0109 0.002
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0021 0.0156 0.0065
Brugia malayi nuclear hormone receptor 0.0026 0.0273 0.0273
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.002 0.0109 0.0017
Schistosoma mansoni opsin-like receptor 0.0021 0.0156 0.0065
Onchocerca volvulus Bile acid receptor homolog 0.0026 0.0273 0.2002
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.002 0.0109 0.002
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0021 0.0156 0.0076
Brugia malayi neuropeptide F receptor 0.0021 0.0156 0.0156
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0156 0.0076
Brugia malayi hypothetical protein 0.0021 0.0156 0.0156
Onchocerca volvulus 0.0021 0.0156 0.0577
Echinococcus granulosus neuropeptide receptor A26 0.0021 0.0156 0.0076
Loa Loa (eye worm) LGC-31 protein 0.002 0.0109 0.0017
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.002 0.0109 0.002
Echinococcus multilocularis neuropeptides capa receptor 0.0021 0.0156 0.0076
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0021 0.0156 0.0076
Schistosoma mansoni hypothetical protein 0.0035 0.0525 0.0437
Echinococcus granulosus tumor protein p63 0.0326 0.8564 1
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.002 0.0109 0.0017
Loa Loa (eye worm) hypothetical protein 0.0168 0.4209 0.4156
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.002 0.0109 0.0017
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0273 0.0213
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.002 0.0109 0.002
Onchocerca volvulus 0.0021 0.0156 0.0577
Echinococcus multilocularis g protein coupled receptor 0.0021 0.0156 0.0076
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0021 0.0156 0.0065
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0178 0.1028
Loa Loa (eye worm) hypothetical protein 0.002 0.0109 0.0017
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.0267 0.6924 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0156 0.0076
Schistosoma mansoni hypothetical protein 0.0021 0.0156 0.0065
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.012 0.2868 1
Schistosoma mansoni nAChR subunit 0.002 0.0109 0.0017
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0379 1 1
Brugia malayi follicle stimulating hormone receptor 0.0021 0.0156 0.0156
Leishmania major hypothetical protein, conserved 0.0022 0.0178 0.0309
Echinococcus granulosus hypothetical protein 0.0021 0.0156 0.0076
Echinococcus multilocularis glycine receptor subunit beta 0.002 0.0109 0.002
Echinococcus granulosus family S10 non peptidase ue S10 family 0.0044 0.0792 0.0827
Echinococcus multilocularis pikachurin 0.005 0.0956 0.102
Brugia malayi hypothetical protein 0.0021 0.0156 0.0156
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0026 0.0273 0.0183
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Echinococcus multilocularis neuropeptides capa receptor 0.0021 0.0156 0.0076
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.002 0.0109 0.0017
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.012 0.2868 0.3277
Brugia malayi putative neuropeptide receptor NPR1 0.0021 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Brugia malayi Serotonin receptor 0.0021 0.0156 0.0156
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0026 0.0273 0.0273
Schistosoma mansoni neuropeptide F-like receptor 0.0021 0.0156 0.0065
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0109 0.0109
Schistosoma mansoni thyroid hormone receptor 0.0147 0.3625 0.3566
Echinococcus multilocularis serotonin receptor 0.0168 0.4209 0.486
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0315 0.0315
Loa Loa (eye worm) hypothetical protein 0.0027 0.0301 0.0211
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0525 0.0437
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0026 0.0273 0.0213
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0026 0.0273 0.0183
Brugia malayi Protein kinase domain containing protein 0.0022 0.0178 0.0178
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0109 0.0017
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Loa Loa (eye worm) abnormal epIthelia family member 0.005 0.0956 0.0872
Loa Loa (eye worm) hypothetical protein 0.0026 0.0273 0.0183
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0156 0.0065
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0026 0.0273 0.0183
Brugia malayi Cache domain containing protein 0.0058 0.1166 0.1166
Schistosoma mansoni biogenic amine (5HT) receptor 0.0021 0.0156 0.0065
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0156 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0026 0.0273 0.0273
Loa Loa (eye worm) ACC-1 protein 0.002 0.0109 0.0017
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0021 0.0156 0.0156
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0238 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0109 0.0017
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0026 0.0273 0.0183
Schistosoma mansoni slit 0.005 0.0956 0.0872
Onchocerca volvulus 0.0048 0.0884 0.9472
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0026 0.0273 0.0273
Echinococcus multilocularis g protein coupled receptor 0.0021 0.0156 0.0076
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0021 0.0156 0.0065
Trypanosoma cruzi serine carboxypeptidase (CBP1), putative 0.0049 0.0927 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0109 0.0017
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0021 0.0156 0.0076
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0026 0.0273 0.0213
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0131 0.318 0.3645
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0021 0.0156 0.0076
Echinococcus multilocularis neurogenic locus notch protein 0.005 0.0956 0.102
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0109 0.0109
Echinococcus multilocularis thyroid hormone receptor alpha 0.0147 0.3625 0.417
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.002 0.0109 0.002
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0026 0.0273 0.0183
Echinococcus granulosus ecdysone induced protein 78C 0.0026 0.0273 0.0213
Brugia malayi G-protein coupled receptor 0.0021 0.0156 0.0156
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.0156 0.0065
Schistosoma mansoni neuropeptide receptor 0.0021 0.0156 0.0065
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Echinococcus multilocularis neuropeptide Y receptor 0.0021 0.0156 0.0076
Echinococcus multilocularis g-protein coupled receptor 0.0021 0.0156 0.0076
Loa Loa (eye worm) hypothetical protein 0.0379 1 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0021 0.0156 0.0156
Brugia malayi laminin alpha chain 0.005 0.0956 0.0956
Loa Loa (eye worm) hypothetical protein 0.002 0.0109 0.0017
Echinococcus granulosus tm gpcr rhodopsin 0.0021 0.0156 0.0076
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0884 0.0799
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0156 0.0076
Schistosoma mansoni biogenic amine (5HT) receptor 0.0168 0.4209 0.4156
Onchocerca volvulus 0.0021 0.0156 0.0577
Loa Loa (eye worm) hypothetical protein 0.0024 0.0238 0.0148
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Brugia malayi hypothetical protein 0.0021 0.0156 0.0156
Schistosoma mansoni nAChR subunit 0.002 0.0109 0.0017
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0021 0.0156 0.0065
Echinococcus granulosus neuropeptide receptor 0.0021 0.0156 0.0076
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0026 0.0273 0.0183
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0026 0.0273 0.0213
Schistosoma mansoni lamin 0.0027 0.0315 0.0225
Onchocerca volvulus 0.0027 0.0315 0.2517
Schistosoma mansoni amine GPCR 0.0021 0.0156 0.0065
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.005 0.0956 0.0872
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.012 0.2868 1
Echinococcus granulosus neuropeptides capa receptor 0.0021 0.0156 0.0076
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.002 0.0109 0.002
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.0109 0.002
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0021 0.0156 0.0156
Brugia malayi hypothetical protein 0.0021 0.0156 0.0156
Brugia malayi G protein-coupled receptor 0.0021 0.0156 0.0156
Trypanosoma cruzi serine carboxypeptidase (CBP1), putative 0.0049 0.0927 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0109 0.0017
Loa Loa (eye worm) hypothetical protein 0.002 0.0109 0.0017
Echinococcus granulosus nAChR subunit 0.002 0.0109 0.002
Onchocerca volvulus 0.0021 0.0156 0.0577
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0109 0.0017
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Loa Loa (eye worm) ACC-1 protein 0.002 0.0109 0.0017
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Brugia malayi AKH receptor 0.0021 0.0156 0.0156
Brugia malayi Serotonin receptor 0.0021 0.0156 0.0156
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0156 0.0065
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0156 0.0076
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Schistosoma mansoni hypothetical protein 0.0021 0.0156 0.0065
Brugia malayi RE15519p 0.0021 0.0156 0.0156

Activities

Activity type Activity value Assay description Source Reference
(functional) 0 Manually curated assays from literature Starlite. 6130153
Kd (binding) = 8.7 In vitro ability to block beta-1 adrenergic receptor in guinea pig right atria. ChEMBL. 6130153
Kd (binding) = 8.9 In vitro ability to block beta-2 adrenergic receptor in guinea pig trachea. ChEMBL. 6130153
Kd (functional) = 46 In vivo inihibtion of Beta-1 adrenergic receptor in guinea pig right atria after 40 min ChEMBL. 6130153
Kd (functional) > 60 The compound was tested in vivo for its ability to block Beta-1 adrenergic receptor ChEMBL. 6130153
pA2 (binding) = 8.7 In vitro ability to block beta-1 adrenergic receptor in guinea pig right atria. ChEMBL. 6130153
pA2 (binding) = 8.9 In vitro ability to block beta-2 adrenergic receptor in guinea pig trachea. ChEMBL. 6130153
pA2 (functional) = 46 In vivo inihibtion of Beta-1 adrenergic receptor in guinea pig right atria after 40 min ChEMBL. 6130153
pA2 (functional) > 60 The compound was tested in vivo for its ability to block Beta-1 adrenergic receptor ChEMBL. 6130153

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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