Detailed information for compound 409998

Basic information

Technical information
  • TDR Targets ID: 409998
  • Name: cyclopentyl N-[(2S,3S)-3-[4-[[4-(4-chlorophen yl)-4-hydroxypiperidin-1-yl]methyl]triazol-1- yl]-1,4-diphenylbutan-2-yl]carbamate
  • MW: 628.203 | Formula: C36H42ClN5O3
  • H donors: 2 H acceptors: 4 LogP: 6.28 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(N[C@H]([C@@H](n1nnc(c1)CN1CCC(CC1)(O)c1ccc(cc1)Cl)Cc1ccccc1)Cc1ccccc1)OC1CCCC1
  • InChi: 1S/C36H42ClN5O3/c37-30-17-15-29(16-18-30)36(44)19-21-41(22-20-36)25-31-26-42(40-39-31)34(24-28-11-5-2-6-12-28)33(23-27-9-3-1-4-10-27)38-35(43)45-32-13-7-8-14-32/h1-6,9-12,15-18,26,32-34,44H,7-8,13-14,19-25H2,(H,38,43)/t33-,34-/m0/s1
  • InChiKey: CENPSRMENHBYJI-HEVIKAOCSA-N  


Substructure search Similarity search

Network

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Synonyms

  • cyclopentyl N-[(1S,2S)-1-benzyl-2-[4-[[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]methyl]triazol-1-yl]-3-phenyl-propyl]carbamate
  • N-[(1S,2S)-1-benzyl-2-[4-[[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]methyl]-1-triazolyl]-3-phenylpropyl]carbamic acid cyclopentyl ester
  • cyclopentyl N-[(2S,3S)-3-[4-[[4-(4-chlorophenyl)-4-hydroxy-piperidin-1-yl]methyl]-1,2,3-triazol-1-yl]-1,4-diphenyl-butan-2-yl]carbamate
  • N-[(1S,2S)-1-benzyl-2-[4-[[4-(4-chlorophenyl)-4-hydroxy-piperidino]methyl]triazol-1-yl]-3-phenyl-propyl]carbamic acid cyclopentyl ester
  • cyclopentyl N-[(2S,3S)-3-[4-[[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]methyl]triazol-1-yl]-1,4-di(phenyl)butan-2-yl]carbamate
  • cyclopentyl N-[(1S,2S)-2-[4-[[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]methyl]triazol-1-yl]-3-phenyl-1-(phenylmethyl)propyl]carbamate
  • N-[(1S,2S)-2-[4-[[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]methyl]-1-triazolyl]-3-phenyl-1-(phenylmethyl)propyl]carbamic acid cyclopentyl ester
  • N-[(1S,2S)-1-(benzyl)-2-[4-[[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]methyl]triazol-1-yl]-3-phenyl-propyl]carbamic acid cyclopentyl ester
  • cyclopentyl N-[(2S,3S)-3-[4-[[4-(4-chlorophenyl)-4-hydroxy-piperidin-1-yl]methyl]-1,2,3-triazol-1-yl]-1,4-di(phenyl)butan-2-yl]carbamate
  • AIDS-470571
  • AIDS470571
  • N-((1S,2S)-2-{4-[[4-Hydroxy-4-(4-chlorophenyl)piperidyl]methyl](1,2,3-triazolyl)}-3-phenyl-1-benzylpropyl)cyclopentyloxycarboxamides

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0027 0.0302 0.0297
Onchocerca volvulus 0.0309 0.4606 1
Onchocerca volvulus 0.0167 0.2432 0.512
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0151 0.0288
Schistosoma mansoni acetylcholine receptor subunit beta 0.0143 0.2067 0.3401
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0309 0.4606 0.7581
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0309 0.4606 0.7581
Echinococcus multilocularis General substrate transporter 0.0104 0.1472 0.2422
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0309 0.4606 0.7581
Trichomonas vaginalis sugar transporter, putative 0.0037 0.0462 0.2204
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0613 0.1009
Echinococcus granulosus glycine receptor subunit alpha 1 0.0309 0.4606 0.7581
Loa Loa (eye worm) hypothetical protein 0.0017 0.0151 0.0146
Brugia malayi Sugar transporter family protein 0.0017 0.0151 0.0195
Echinococcus granulosus cpg binding protein 0.003 0.0351 0.0578
Giardia lamblia Prolyl-tRNA synthetase 0.0036 0.0444 1
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0167 0.2432 0.3254
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0102 0.144 1
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0037 0.0455 0.0463
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0455 0.0749
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0014 0.0104 0.0132
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0309 0.4606 0.617
Loa Loa (eye worm) hypothetical protein 0.0309 0.4606 0.4603
Entamoeba histolytica hypothetical protein 0.0037 0.0458 0.0733
Toxoplasma gondii NADPH-glutathione reductase 0.0014 0.0104 0.0194
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0102 0.144 1
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0023 0.0241 0.1641
Toxoplasma gondii sugar transporter ST3 0.0017 0.0151 0.0286
Echinococcus multilocularis solute carrier family 22 0.0017 0.0151 0.0248
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0017 0.0151 0.4893
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0167 0.2432 0.4002
Onchocerca volvulus 0.0309 0.4606 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0167 0.2432 0.3254
Plasmodium falciparum calcium-dependent protein kinase 2 0.0037 0.0455 0.0463
Plasmodium falciparum lysine--tRNA ligase 0.0027 0.0302 0.0262
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0027 0.0302 0.4308
Loa Loa (eye worm) hypothetical protein 0.0309 0.4606 0.4603
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0151 0.0288
Schistosoma mansoni nAChR subunit 0.0309 0.4606 0.7581
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0903 0.1486
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0715 0.1397
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.064 0.1053
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0151 0.0288
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0014 0.0104 0.1428
Plasmodium falciparum mitogen-activated protein kinase 2 0.0195 0.2862 0.3635
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0151 0.0288
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0151 0.0288
Giardia lamblia Lysyl-tRNA synthetase 0.0027 0.0302 0.5847
Echinococcus granulosus cytochrome P450 2K1 0.0007 0.0005 0.0008
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.004 0.0503 0.3467
Loa Loa (eye worm) RNA binding protein 0.0066 0.0903 0.0898
Echinococcus granulosus tumor protein p63 0.0335 0.5001 0.823
Onchocerca volvulus 0.0028 0.0326 0.0395
Loa Loa (eye worm) hypothetical protein 0.0017 0.0151 0.0146
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0713 0.1174
Schistosoma mansoni hypothetical protein 0.0406 0.6076 1
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0151 0.0288
Loa Loa (eye worm) hypothetical protein 0.0036 0.0444 0.0439
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0091 0.1285 0.8917
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0143 0.2067 0.3401
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0036 0.0444 0.0666
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0037 0.0455 0.0886
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0027 0.0302 1
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0015 0.0118 0.0113
Trypanosoma brucei glucose transporter, putative 0.0037 0.0462 0.6623
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0302 0.4297
Brugia malayi Cation transporter family protein 0.0309 0.4606 0.617
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0302 0.0297
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0613 0.1009
Schistosoma mansoni cytochrome P450 0.0007 0.0005 0.0008
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0309 0.4606 0.7581
Loa Loa (eye worm) LGC-31 protein 0.0309 0.4606 0.4603
Trypanosoma brucei glucose transporter, putative 0.0037 0.0462 0.6623
Trypanosoma brucei THT1 - hexose transporter, putative 0.0037 0.0462 0.6623
Loa Loa (eye worm) hypothetical protein 0.0143 0.2067 0.2063
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0037 0.0455 0.0603
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0309 0.4606 0.617
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0309 0.4606 0.7581
Echinococcus multilocularis 0.0007 0.0005 0.0008
Plasmodium falciparum calcium-dependent protein kinase 3 0.0037 0.0455 0.0463
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0151 0.0288
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0151 0.0288
Loa Loa (eye worm) MBCTL1 0.0054 0.0713 0.0708
Entamoeba histolytica protein kinase, putative 0.0037 0.0455 0.072
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0309 0.4606 0.7581
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0143 0.2067 0.3401
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0309 0.4606 0.617
Giardia lamblia Sugar-proton symporter 0.0017 0.0151 0.138
Schistosoma mansoni neurotransmitter gated ion channel 0.0143 0.2067 0.3401
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0462 0.2204
Loa Loa (eye worm) hypothetical protein 0.0017 0.0151 0.0146
Loa Loa (eye worm) hypothetical protein 0.0167 0.2432 0.2428
Echinococcus multilocularis cpg binding protein 0.003 0.0351 0.0578
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0455 0.0749
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0302 0.0261
Loa Loa (eye worm) hypothetical protein 0.0309 0.4606 0.4603
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0462 0.2204
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0014 0.0104 0.0171
Brugia malayi RNA binding protein 0.0066 0.0903 0.1204
Toxoplasma gondii transporter, major facilitator family protein 0.0017 0.0151 0.0286
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0309 0.4606 0.617
Loa Loa (eye worm) acetylcholine receptor protein 0.0143 0.2067 0.2063
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0713 0.1174
Echinococcus granulosus lysyl tRNA synthetase 0.0027 0.0302 0.0498
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0143 0.2067 0.2765
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0151 0.0288
Loa Loa (eye worm) GABA receptor subunit 0.0167 0.2432 0.2428
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0017 0.0151 0.4893
Brugia malayi excitatory GABA receptor EXP-1A 0.0309 0.4606 0.617
Loa Loa (eye worm) hypothetical protein 0.0143 0.2067 0.2063
Plasmodium vivax sugar transporter, putative 0.0017 0.0151 0.0062
Leishmania major glucose transporter, lmgt1 0.0037 0.0462 0.6623
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0014 0.0104 0.3315
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0121 0.173 0.2847
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0309 0.4606 0.7581
Loa Loa (eye worm) hypothetical protein 0.0309 0.4606 0.4603
Brugia malayi Thioredoxin reductase 0.004 0.0503 0.0667
Loa Loa (eye worm) hypothetical protein 0.0496 0.7462 0.746
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0017 0.0151 0.0062
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0013 0.0087 0.2752
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0151 0.0288
Loa Loa (eye worm) hypothetical protein 0.0309 0.4606 0.4603
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0121 0.173 0.2847
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0613 0.1009
Echinococcus multilocularis solute carrier family 22 0.0017 0.0151 0.0248
Loa Loa (eye worm) hypothetical protein 0.0143 0.2067 0.2063
Leishmania major trypanothione reductase 0.004 0.0503 0.7208
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0151 0.0288
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0104 0.1428
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0151 0.0288
Trypanosoma brucei glucose transporter, putative 0.0037 0.0462 0.6623
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0014 0.0104 0.1428
Schistosoma mansoni protein kinase 0.0037 0.0455 0.0749
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0252 0.0415
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0151 0.0288
Plasmodium vivax hexose transporter 0.0121 0.173 0.2143
Loa Loa (eye worm) major facilitator superfamily transporter 0.0017 0.0151 0.0146
Trichomonas vaginalis sugar transporter, putative 0.0037 0.0462 0.2204
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0017 0.0151 0.0248
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0195 0.2862 0.5624
Treponema pallidum NADH oxidase 0.0014 0.0104 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.034 0.0335
Trypanosoma brucei glucose transporter 1E 0.0037 0.0462 0.6623
Loa Loa (eye worm) hypothetical protein 0.0017 0.0151 0.0146
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0458 0.0754
Loa Loa (eye worm) hypothetical protein 0.0054 0.0713 0.0708
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0613 0.1009
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0462 0.6623
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0143 0.2067 0.2765
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0042 0.0535 0.7677
Echinococcus granulosus glycine receptor subunit beta 0.0309 0.4606 0.7581
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0143 0.2067 0.2765
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0613 0.1009
Mycobacterium tuberculosis Probable oxidoreductase 0.0102 0.144 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0151 0.0146
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0903 0.1486
Toxoplasma gondii sugar transporter ST2 0.0017 0.0151 0.0286
Plasmodium vivax glutathione reductase, putative 0.004 0.0503 0.0526
Onchocerca volvulus 0.0309 0.4606 1
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0151 0.0288
Echinococcus granulosus solute carrier family 22 0.0017 0.0151 0.0248
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0091 0.1285 0.8917
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0309 0.4606 0.617
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0151 0.0288
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0309 0.4606 0.7581
Brugia malayi hypothetical protein 0.0143 0.2067 0.2765
Plasmodium falciparum flap endonuclease 1 0.0027 0.0302 0.0261
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0455 0.0749
Loa Loa (eye worm) hypothetical protein 0.0309 0.4606 0.4603
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0121 0.173 0.2847
Trypanosoma brucei glucose transporter, putative 0.0037 0.0462 0.6623
Brugia malayi mbt repeat family protein 0.0047 0.0613 0.0816
Onchocerca volvulus 0.0049 0.064 0.1098
Loa Loa (eye worm) hypothetical protein 0.0167 0.2432 0.2428
Echinococcus multilocularis nAChR subunit 0.0309 0.4606 0.7581
Loa Loa (eye worm) hypothetical protein 0.0167 0.2432 0.2428
Schistosoma mansoni sugar transporter 0.0017 0.0151 0.0248
Brugia malayi hypothetical protein 0.0037 0.0458 0.0607
Trichomonas vaginalis myo-inositol transporter, putative 0.0017 0.0151 0.0288
Trypanosoma brucei THT1 - hexose transporter, putative 0.0037 0.0462 0.6623
Echinococcus multilocularis nAChR subunit 0.0167 0.2432 0.4002
Loa Loa (eye worm) hypothetical protein 0.0309 0.4606 0.4603
Plasmodium falciparum hexose transporter 0.0121 0.173 0.2143
Leishmania major hypothetical protein, conserved 0.0053 0.0695 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0309 0.4606 0.617
Loa Loa (eye worm) hypothetical protein 0.0017 0.0151 0.0146
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0151 0.0288
Toxoplasma gondii thioredoxin reductase 0.004 0.0503 0.0979
Loa Loa (eye worm) glutathione reductase 0.004 0.0503 0.0498
Schistosoma mansoni glucose transport protein 0.0121 0.173 0.2847
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0151 0.0288
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0014 0.0104 0.0171
Loa Loa (eye worm) major facilitator superfamily transporter 0.0017 0.0151 0.0146
Schistosoma mansoni nAChR subunit 0.0309 0.4606 0.7581
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0042 0.0535 0.7677
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0151 0.0288
Echinococcus granulosus glycine receptor subunit alpha 1 0.0309 0.4606 0.7581
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0695 0.1359
Loa Loa (eye worm) hypothetical protein 0.0143 0.2067 0.2063
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0455 0.0749
Loa Loa (eye worm) hypothetical protein 0.0143 0.2067 0.2063
Plasmodium vivax proline--tRNA ligase, putative 0.0042 0.0535 0.0568
Echinococcus granulosus calcium dependent protein kinase 0.0035 0.042 0.0691
Schistosoma mansoni nAChR subunit 0.0309 0.4606 0.7581
Loa Loa (eye worm) hypothetical protein 0.0309 0.4606 0.4603
Schistosoma mansoni protein kinase 0.0037 0.0455 0.0749
Trichomonas vaginalis sugar transporter, putative 0.0037 0.0462 0.2204
Leishmania major glucose transporter, lmgt2 0.0037 0.0462 0.6623
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0309 0.4606 0.617
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0143 0.2067 0.2765
Loa Loa (eye worm) hypothetical protein 0.0167 0.2432 0.2428
Trypanosoma brucei glucose transporter, putative 0.0037 0.0462 0.6623
Schistosoma mansoni glucose transporter 0.0017 0.0151 0.0248
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0613 0.1009
Trypanosoma cruzi trypanothione reductase, putative 0.004 0.0503 0.7208
Toxoplasma gondii facilitative glucose transporter GT1 0.0121 0.173 0.3396
Brugia malayi mbt repeat family protein 0.0047 0.0613 0.0816
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0036 0.0444 0.073
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0151 0.0288
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0036 0.0444 0.073
Echinococcus granulosus dnaJ subfamily B 0.0406 0.6076 1
Loa Loa (eye worm) hypothetical protein 0.0309 0.4606 0.4603
Loa Loa (eye worm) hypothetical protein 0.0017 0.0151 0.0146
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0309 0.4606 0.617
Schistosoma mansoni lysyl-tRNA synthetase 0.0027 0.0302 0.0498
Schistosoma mansoni hypothetical protein 0.0007 0.0005 0.0008
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0309 0.4606 0.4603
Loa Loa (eye worm) hypothetical protein 0.0309 0.4606 0.4603
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0309 0.4606 0.7581
Mycobacterium ulcerans integral membrane transport protein 0.0017 0.0151 0.4893
Loa Loa (eye worm) hypothetical protein 0.0167 0.2432 0.2428
Loa Loa (eye worm) hypothetical protein 0.0017 0.0151 0.0146
Schistosoma mansoni protein kinase 0.0037 0.0455 0.0749
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0309 0.4606 0.7581
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0695 1
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0017 0.0151 0.2108
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0036 0.0444 0.0588
Loa Loa (eye worm) hypothetical protein 0.0143 0.2067 0.2063
Leishmania major glucose transporter/membrane transporter D2, putative 0.0037 0.0462 0.6623
Echinococcus granulosus glycine receptor subunit alpha 1 0.0309 0.4606 0.7581
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0309 0.4606 0.617
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0458 0.0754
Schistosoma mansoni nAChR subunit 0.0309 0.4606 0.7581
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0186 0.2734 0.45
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0151 0.0288
Loa Loa (eye worm) hypothetical protein 0.0309 0.4606 0.4603
Leishmania major glucose transporter, lmgt3 0.0037 0.0462 0.6623
Echinococcus granulosus solute carrier family 22 0.0017 0.0151 0.0248
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0104 0.1428
Loa Loa (eye worm) hypothetical protein 0.0143 0.2067 0.2063
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0042 0.0535 0.7677
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0036 0.0444 0.073
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0042 0.0535 0.7677
Echinococcus granulosus General substrate transporter 0.0104 0.1472 0.2422
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0309 0.4606 0.7581
Brugia malayi Cam kinase protein 1 0.0037 0.0455 0.0603
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0091 0.1285 0.8917
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0309 0.4606 0.7581
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0151 0.0288
Loa Loa (eye worm) hypothetical protein 0.0309 0.4606 0.4603
Loa Loa (eye worm) hypothetical protein 0.0354 0.5287 0.5285
Plasmodium vivax CDK-related protein kinase 6, putative 0.0512 0.7693 1
Loa Loa (eye worm) hypothetical protein 0.0309 0.4606 0.4603
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0309 0.4606 0.7581
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0014 0.0104 0.0777
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0023 0.0241 0.1641
Loa Loa (eye worm) sugar transporter 0.0017 0.0151 0.0146
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0903 0.1486
Loa Loa (eye worm) hypothetical protein 0.0017 0.0151 0.0146
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0309 0.4606 0.7581
Loa Loa (eye worm) hypothetical protein 0.0017 0.0151 0.0146
Onchocerca volvulus 0.0143 0.2067 0.43
Loa Loa (eye worm) hypothetical protein 0.0049 0.064 0.0635
Schistosoma mansoni sugar transporter 0.0017 0.0151 0.0248
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0151 0.0195
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0151 0.0288
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0104 0.1428
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0151 0.0288
Schistosoma mansoni nAChR subunit 0.0143 0.2067 0.3401
Schistosoma mansoni glucose transport protein 0.0121 0.173 0.2847
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0695 0.0779
Schistosoma mansoni nAChR subunit 0.0309 0.4606 0.7581
Leishmania major hypothetical protein, conserved 0.0017 0.0151 0.2108
Brugia malayi hypothetical protein 0.0143 0.2067 0.2765
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0104 0.1428
Schistosoma mansoni glucose transport protein 0.0121 0.173 0.2847
Entamoeba histolytica protein kinase, putative 0.0037 0.0455 0.072
Onchocerca volvulus Putative nachr subunit 0.0309 0.4606 1
Echinococcus granulosus tar DNA binding protein 0.0066 0.0903 0.1486
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0309 0.4606 0.7581
Echinococcus multilocularis solute carrier family 22 0.0017 0.0151 0.0248
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0151 0.0195
Brugia malayi hypothetical protein 0.0017 0.0151 0.0195
Echinococcus multilocularis calcium dependent protein kinase 0.0035 0.042 0.0691
Brugia malayi TAR-binding protein 0.0066 0.0903 0.1204
Plasmodium falciparum glutathione reductase 0.004 0.0503 0.0526
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0143 0.2067 0.3401
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0121 0.173 0.2847
Leishmania major lysyl-tRNA synthetase, putative 0.0027 0.0302 0.4308
Brugia malayi major facilitator superfamily protein 0.0017 0.0151 0.0195
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0143 0.2067 0.3401
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0695 0.0779
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0462 0.6623
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0102 0.144 1
Echinococcus granulosus flap endonuclease 1 0.0027 0.0302 0.0496
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.173 1
Loa Loa (eye worm) hypothetical protein 0.0143 0.2067 0.2063
Loa Loa (eye worm) hypothetical protein 0.0309 0.4606 0.4603
Onchocerca volvulus 0.0143 0.2067 0.43
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0713 0.1174
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0151 0.0288
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0143 0.2067 0.2765
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0309 0.4606 0.7581
Mycobacterium tuberculosis Probable reductase 0.0091 0.1285 0.8917
Schistosoma mansoni nAChR subunit 0.0309 0.4606 0.7581
Brugia malayi hypothetical protein 0.0143 0.2067 0.2765
Echinococcus granulosus solute carrier family 22 0.0017 0.0151 0.0248
Plasmodium falciparum protein kinase 6 0.0512 0.7693 1
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0027 0.0302 0.1222
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0695 0.0779
Echinococcus multilocularis synaptic vesicle 2 protein 0.0017 0.0151 0.0248
Echinococcus multilocularis tumor protein p63 0.0335 0.5001 0.823
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0455 0.0749
Loa Loa (eye worm) hypothetical protein 0.0167 0.2432 0.2428
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0151 0.0288
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0613 0.0609
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0036 0.0444 0.0588
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0613 0.1039
Echinococcus multilocularis thioredoxin glutathione reductase 0.0041 0.0511 0.084
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0151 0.0288
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0037 0.0455 0.6518
Schistosoma mansoni neurotransmitter gated ion channel 0.0143 0.2067 0.3401
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0017 0.0151 0.1014
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0151 0.0288
Brugia malayi hypothetical protein 0.0017 0.0151 0.0195
Trypanosoma brucei glucose transporter, putative 0.0037 0.0462 0.6623
Brugia malayi hypothetical protein 0.0143 0.2067 0.2765
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0813 0.1338
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0036 0.0444 0.3056
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0695 1
Trypanosoma brucei sugar transporter, putative 0.0017 0.0151 0.2108
Loa Loa (eye worm) hypothetical protein 0.0017 0.0151 0.0146
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0695 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0309 0.4606 0.617
Leishmania major protein kinase, putative 0.0037 0.0455 0.6518
Brugia malayi Sugar transporter family protein 0.0121 0.173 0.2313
Entamoeba histolytica hypothetical protein 0.0037 0.0458 0.0733
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0037 0.0455 0.0463
Onchocerca volvulus 0.0309 0.4606 1
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0496 0.7462 1
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0309 0.4606 0.617
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0903 0.1486
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0014 0.0104 0.1428
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0042 0.0535 0.1043
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0104 0.1428
Loa Loa (eye worm) hypothetical protein 0.0143 0.2067 0.2063
Schistosoma mansoni sugar transporter 0.0017 0.0151 0.0248
Onchocerca volvulus 0.0143 0.2067 0.43
Echinococcus multilocularis glycine receptor subunit beta 0.0309 0.4606 0.7581
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0302 0.5825
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0151 0.0288
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0455 0.0749
Brugia malayi major facilitator superfamily protein 0.0017 0.0151 0.0195
Loa Loa (eye worm) thioredoxin reductase 0.004 0.0503 0.0498
Echinococcus granulosus nAChR subunit 0.0309 0.4606 0.7581
Loa Loa (eye worm) hypothetical protein 0.0036 0.0444 0.0439
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0014 0.0104 0.3315
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0037 0.0455 0.0463
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0309 0.4606 0.4603
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0309 0.4606 0.617
Schistosoma mansoni neurotransmitter gated ion channel 0.0167 0.2432 0.4002
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0017 0.0151 1
Echinococcus granulosus solute carrier family 22 0.0017 0.0151 0.0248
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0026 0.0021
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0036 0.0444 0.073
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0309 0.4606 0.7581
Brugia malayi glutathione reductase 0.004 0.0503 0.0667
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0143 0.2067 0.3401
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0302 0.1217
Trypanosoma cruzi sugar transporter, putative 0.0017 0.0151 0.2108
Loa Loa (eye worm) hypothetical protein 0.0143 0.2067 0.2063
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0903 0.1204
Schistosoma mansoni cpg binding protein 0.0028 0.0326 0.0537
Schistosoma mansoni cpg binding protein 0.003 0.0351 0.0578
Loa Loa (eye worm) hypothetical protein 0.0017 0.0151 0.0146
Brugia malayi CXXC zinc finger family protein 0.0028 0.0326 0.0431
Echinococcus multilocularis lysyl tRNA synthetase 0.0027 0.0302 0.0498
Trichomonas vaginalis glucose transporter, putative 0.0037 0.0462 0.2204
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0014 0.0104 0.1428
Entamoeba histolytica hypothetical protein 0.0167 0.2432 1
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0903 0.0898
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0302 0.0496
Trypanosoma brucei glucose transporter 2A 0.0037 0.0462 0.6623
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0143 0.2067 0.2063
Toxoplasma gondii protein kinase, putative 0.0341 0.5085 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0309 0.4606 0.7581
Echinococcus multilocularis dnaJ subfamily B 0.0406 0.6076 1
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0455 0.216
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0121 0.173 0.2847
Plasmodium falciparum calcium-dependent protein kinase 4 0.0037 0.0455 0.0463
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0309 0.4606 0.7581
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0455 0.0749
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0151 0.0288
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0017 0.0151 0.1014
Loa Loa (eye worm) hypothetical protein 0.0017 0.0151 0.0146
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0014 0.0104 0.1428
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0151 0.0288
Schistosoma mansoni acetylcholine receptor-related 0.0143 0.2067 0.3401
Brugia malayi Cytochrome P450 family protein 0.0027 0.031 0.0408
Trichomonas vaginalis glucose transporter, putative 0.0017 0.0151 0.0288
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0309 0.4606 0.7581
Plasmodium falciparum calcium-dependent protein kinase 5 0.0037 0.0455 0.0463
Toxoplasma gondii sugar transporter ST1 0.0017 0.0151 0.0286
Loa Loa (eye worm) hypothetical protein 0.0143 0.2067 0.2063
Echinococcus granulosus nAChR subunit 0.0167 0.2432 0.4002
Loa Loa (eye worm) hypothetical protein 0.0017 0.0151 0.0146
Chlamydia trachomatis lysine--tRNA ligase 0.0027 0.0302 1
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0309 0.4606 0.7581
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0302 0.4297
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0026 0.0044
Leishmania major myo-inositol/proton symporter (MIT) 0.0017 0.0151 0.2108
Trypanosoma brucei glucose transporter, putative 0.0037 0.0462 0.6623
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0027 0.0302 0.2072
Loa Loa (eye worm) hypothetical protein 0.0143 0.2067 0.2063
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0167 0.2432 0.4002
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0151 0.0195
Loa Loa (eye worm) hypothetical protein 0.0143 0.2067 0.2063
Schistosoma mansoni hypothetical protein 0.0288 0.4276 0.7038
Plasmodium vivax calcium-dependent protein kinase, putative 0.0037 0.0455 0.0463
Schistosoma mansoni hypothetical protein 0.0024 0.0252 0.0415
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0309 0.4606 0.4603
Schistosoma mansoni lysyl-tRNA synthetase 0.0027 0.0302 0.0498
Loa Loa (eye worm) hypothetical protein 0.0017 0.0151 0.0146
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0151 0.0288
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0151 0.2108
Trypanosoma cruzi hexose transporter, putative 0.002 0.0204 0.2878
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0151 0.0288
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0309 0.4606 0.7581
Trichomonas vaginalis glucose transporter, putative 0.0037 0.0462 0.2204
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0713 0.095
Schistosoma mansoni nAChR subunit 0.0143 0.2067 0.3401
Loa Loa (eye worm) hypothetical protein 0.0143 0.2067 0.2063
Echinococcus multilocularis solute carrier family 22 0.0017 0.0151 0.0248
Mycobacterium ulcerans sugar transporter 0.0017 0.0151 0.4893
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0121 0.173 0.2847
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0309 0.4606 0.7581
Loa Loa (eye worm) hypothetical protein 0.0053 0.0695 0.069
Schistosoma mansoni sugar transporter 0.0017 0.0151 0.0248
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0014 0.0104 0.3315
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0014 0.0104 0.1428
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.001 0.0048 0.0057
Loa Loa (eye worm) hypothetical protein 0.0167 0.2432 0.2428
Mycobacterium tuberculosis Probable dehydrogenase 0.0091 0.1285 0.8917
Trypanosoma cruzi trypanothione reductase, putative 0.0014 0.0104 0.1428
Toxoplasma gondii lysine-tRNA ligase 0.0027 0.0302 0.0585
Brugia malayi hypothetical protein 0.0017 0.0151 0.0195
Giardia lamblia Hexose transporter 0.0017 0.0151 0.138
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0037 0.0455 0.045
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0091 0.1285 0.8917
Brugia malayi Cation transporter family protein 0.0309 0.4606 0.617
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0326 0.0321
Entamoeba histolytica hypothetical protein 0.0037 0.0458 0.0733
Plasmodium vivax thioredoxin reductase, putative 0.004 0.0503 0.0526
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0025 0.0026
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0151 0.0288
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0713 0.1174
Trypanosoma brucei trypanothione reductase 0.004 0.0503 0.7208
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0017 0.0151 0.0248
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0462 0.6623
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0903 0.0898
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0037 0.0455 0.045
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0151 0.0288
Schistosoma mansoni flap endonuclease-1 0.0024 0.0262 0.0432
Echinococcus granulosus synaptic vesicle 2 protein 0.0017 0.0151 0.0248
Onchocerca volvulus 0.0047 0.0613 0.1039
Onchocerca volvulus 0.0167 0.2432 0.512
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0042 0.0535 0.7677
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0903 0.1486
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0143 0.2067 0.2765
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0143 0.2067 0.2063
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0151 0.0288
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0014 0.0104 0.1428
Loa Loa (eye worm) ACC-1 protein 0.0309 0.4606 0.4603
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0167 0.2432 0.3254
Trypanosoma brucei THT1 - hexose transporter, putative 0.0037 0.0462 0.6623
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0309 0.4606 0.4603
Schistosoma mansoni hypothetical protein 0.0121 0.173 0.2847
Loa Loa (eye worm) hypothetical protein 0.0309 0.4606 0.4603
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0458 0.0754
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0309 0.4606 0.4603
Loa Loa (eye worm) hypothetical protein 0.0167 0.2432 0.2428
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0186 0.2734 0.45
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0014 0.0104 0.0194
Brugia malayi lysyl-tRNA synthetase 0.0027 0.0302 0.0399
Entamoeba histolytica hypothetical protein 0.0027 0.0302 0.0004
Plasmodium falciparum calcium-dependent protein kinase 1 0.0037 0.0455 0.0463
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0121 0.173 0.2847
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0252 0.0911
Entamoeba histolytica hypothetical protein 0.0037 0.0458 0.0733
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0014 0.0104 0.1428
Onchocerca volvulus 0.0309 0.4606 1
Plasmodium falciparum proline--tRNA ligase 0.0042 0.0535 0.0568
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0151 0.0288
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0195 0.2862 0.3635
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0151 0.0288
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0309 0.4606 0.7581
Echinococcus granulosus glycine receptor subunit beta 0.0309 0.4606 0.7581
Loa Loa (eye worm) hypothetical protein 0.0037 0.0455 0.045
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0037 0.0455 0.0886
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0903 0.1486
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0121 0.173 0.2847
Echinococcus granulosus Sugar transporter ERD6 protein 0.0017 0.0151 0.0248
Brugia malayi Flap endonuclease-1 0.0027 0.0302 0.0398
Schistosoma mansoni cpg binding protein 0.003 0.0351 0.0578
Onchocerca volvulus 0.0309 0.4606 1
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0023 0.0241 0.1641
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0014 0.0104 0.0687
Plasmodium vivax lysine--tRNA ligase, putative 0.0027 0.0302 0.0262
Loa Loa (eye worm) hypothetical protein 0.0047 0.0613 0.0609
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.031 0.0305
Schistosoma mansoni nAChR subunit 0.0309 0.4606 0.7581
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0014 0.0104 0.0171
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0036 0.0444 0.209
Echinococcus granulosus thioredoxin glutathione reductase 0.0041 0.0511 0.084
Brugia malayi Sugar transporter family protein 0.0017 0.0151 0.0195
Loa Loa (eye worm) sugar transporter 0.0121 0.173 0.1726
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0151 0.0288
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0713 0.1174
Plasmodium falciparum thioredoxin reductase 0.004 0.0503 0.0526
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0026 0.0044
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0151 0.0288
Brugia malayi hypothetical protein 0.0034 0.0411 0.0544
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0309 0.4606 0.4603
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0037 0.0455 0.0886
Schistosoma mansoni hypothetical protein 0.0037 0.0458 0.0754
Trichomonas vaginalis sugar transport protein, putative 0.0017 0.0151 0.0288
Echinococcus multilocularis glycine receptor subunit beta 0.0309 0.4606 0.7581
Trypanosoma brucei glucose transporter, putative 0.0037 0.0462 0.6623
Loa Loa (eye worm) hypothetical protein 0.0309 0.4606 0.4603
Plasmodium falciparum protein kinase 7 0.0341 0.5085 0.6564
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0309 0.4606 0.617
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0091 0.1285 0.8917
Trypanosoma cruzi glucose transporter, putative 0.0017 0.0151 0.2108
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0037 0.0455 0.0749
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0151 0.0288
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0309 0.4606 0.617
Loa Loa (eye worm) hypothetical protein 0.0309 0.4606 0.4603
Trypanosoma cruzi hexose transporter 0.0037 0.0462 0.6623
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0104 0.1428
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.001 0.0048 0.0057
Brugia malayi hypothetical protein 0.0143 0.2067 0.2765
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0252 0.0415
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0455 0.0749
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0167 0.2432 0.3254
Brugia malayi hypothetical protein 0.0053 0.0695 0.0926
Loa Loa (eye worm) hypothetical protein 0.0143 0.2067 0.2063
Brugia malayi Cation transporter family protein 0.0309 0.4606 0.617
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0302 0.4297
Loa Loa (eye worm) ACC-1 protein 0.0309 0.4606 0.4603
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0014 0.0104 0.1428
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0027 0.0302 0.4308
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0014 0.0104 0.1428
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0309 0.4606 0.617
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0027 0.0302 1
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0302 0.0584
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0613 0.1009

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 26 % Inhibition of HIV1 protease at 5 uM ChEMBL. 17181152
Inhibition (binding) = 26 % Inhibition of HIV1 protease at 5 uM ChEMBL. 17181152

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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