Detailed information for compound 421853

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 243.347 | Formula: C14H15N2S+
  • H donors: 0 H acceptors: 0 LogP: 3.55 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(c1ccc2c(c1)c1c(s2)ccc[n+]1C)C
  • InChi: 1S/C14H15N2S/c1-15(2)10-6-7-12-11(9-10)14-13(17-12)5-4-8-16(14)3/h4-9H,1-3H3/q+1
  • InChiKey: JRTFLVVRPKSJDH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma cruzi trypanothione reductase, putative Curated by TDR Targets References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast trypanothione reductase, putative 492 aa 548 aa 21.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi gonadotropin-releasing hormone receptor 2 0.00800788 0.0242941 0.0357663
Loa Loa (eye worm) hypothetical protein 0.00701941 0.0175052 0.0574095
Entamoeba histolytica rodhanase-like domain containing protein 0.0350034 0.209701 1
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.00478437 0.00215479 0.00728778
Brugia malayi glutathione reductase 0.0175629 0.0899186 0.13238
Echinococcus granulosus tm gpcr rhodopsin 0.00800788 0.0242941 0.0809088
Schistosoma mansoni amine GPCR 0.00800788 0.0242941 0.0726461
Brugia malayi Melatonin receptor type 1A 0.00800788 0.0242941 0.0357663
Brugia malayi Dopamine receptor protein 1 0.00800788 0.0242941 0.0357663
Echinococcus multilocularis tachykinin peptides receptor 99D 0.00800788 0.0242941 0.0809088
Brugia malayi Tachykinin-like peptides receptor 99D 0.00800788 0.0242941 0.0357663
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.00661528 0.0147296 0.0130296
Trichomonas vaginalis guanylate cyclase, putative 0.00478437 0.00215479 0.00728778
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00800788 0.0242941 0.0726461
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088
Trichomonas vaginalis AGC family protein kinase 0.0140166 0.0655625 0.248301
Trichomonas vaginalis conserved hypothetical protein 0.00478437 0.00215479 0.00728778
Echinococcus multilocularis dro:myosuppressin receptor 0.00800788 0.0242941 0.0809088
Schistosoma mansoni serine/threonine protein kinase 0.0067146 0.0154118 0.0450404
Schistosoma mansoni neuropeptide receptor 0.00800788 0.0242941 0.0726461
Brugia malayi Cyclic-nucleotide gated cation channel 0.0104727 0.0412225 0.0606886
Onchocerca volvulus 0.00800788 0.0242941 0.0097075
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.00661528 0.0147296 0.0478021
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.00661528 0.0147296 0.0429203
Trypanosoma cruzi hypothetical protein, conserved 0.00661528 0.0147296 0.0130296
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.00661528 0.0147296 0.0478021
Trichomonas vaginalis guanylate cyclase, putative 0.00478437 0.00215479 0.00728778
Schistosoma mansoni neuropeptide F-like receptor 0.00800788 0.0242941 0.0726461
Echinococcus granulosus rhodopsin orphan GPCR 0.00800788 0.0242941 0.0809088
Brugia malayi Dopamine receptor protein 2 0.00800788 0.0242941 0.0357663
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0466686 0.289818 1
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0104727 0.0412225 0.139505
Mycobacterium tuberculosis Possible mycolic acid synthase UmaA 0.0141088 0.0661958 0.69904
Onchocerca volvulus 0.00800788 0.0242941 0.0097075
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0067146 0.0154118 0.0501633
Schistosoma mansoni voltage-gated potassium channel 0.0152571 0.0740819 0.227383
Echinococcus granulosus cGMP dependent protein kinase 1 0.0067146 0.0154118 0.0501633
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0104727 0.0412225 0.139505
Brugia malayi ORL1-like opioid receptor 0.00800788 0.0242941 0.0357663
Schistosoma mansoni alpha-1 adrenergic receptor 0.00800788 0.0242941 0.0726461
Echinococcus granulosus rhodopsin orphan GPCR 0.00800788 0.0242941 0.0809088
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.00883198 0.0299541 0.1005
Loa Loa (eye worm) hypothetical protein 0.0320784 0.189612 0.653144
Echinococcus granulosus single minded 2 0.00478437 0.00215479 0.00427542
Brugia malayi RE15519p 0.00800788 0.0242941 0.0357663
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.00661528 0.0147296 0.0130296
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.00800788 0.0242941 0.0726461
Onchocerca volvulus 0.00800788 0.0242941 0.0097075
Trichomonas vaginalis guanylate cyclase, putative 0.00478437 0.00215479 0.00728778
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088
Mycobacterium tuberculosis Conserved hypothetical protein 0.00661528 0.0147296 0.0461113
Echinococcus granulosus g protein coupled receptor 0.00800788 0.0242941 0.0809088
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.00608607 0.0110949 0.0287522
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.00608607 0.0110949 0.031624
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00800788 0.0242941 0.0726461
Schistosoma mansoni voltage-gated potassium channel 0.051453 0.322678 1
Brugia malayi hypothetical protein 0.00800788 0.0242941 0.0357663
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.00608607 0.0110949 0.5
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.00800788 0.0242941 0.0726461
Echinococcus granulosus peptide allatostatin:somatostatin 0.00800788 0.0242941 0.0809088
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0104727 0.0412225 0.125258
Trichomonas vaginalis AGC family protein kinase 0.00460453 0.000919629 0.00259291
Echinococcus multilocularis g protein coupled receptor 0.00800788 0.0242941 0.0809088
Echinococcus granulosus serine/threonine protein kinase 0.00951143 0.0346205 0.116653
Plasmodium falciparum glutathione reductase 0.0175629 0.0899186 0.282568
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088
Echinococcus granulosus allatostatin A receptor 0.00800788 0.0242941 0.0809088
Brugia malayi hypothetical protein 0.00800788 0.0242941 0.0357663
Onchocerca volvulus 0.00800788 0.0242941 0.0097075
Mycobacterium leprae Conserved hypothetical protein 0.00661528 0.0147296 1
Echinococcus granulosus neuropeptide receptor 0.00800788 0.0242941 0.0809088
Mycobacterium ulcerans hypothetical protein 0.00661528 0.0147296 0.0659638
Trichomonas vaginalis conserved hypothetical protein 0.00661528 0.0147296 0.0550847
Entamoeba histolytica protein kinase, putative 0.0140166 0.0655625 0.30962
Mycobacterium tuberculosis Conserved protein 0.00661528 0.0147296 0.0461113
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0350034 0.209701 0.796174
Echinococcus granulosus voltage gated potassium channel 0.0152571 0.0740819 0.253245
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.00800788 0.0242941 0.0726461
Plasmodium vivax glutathione reductase, putative 0.0175629 0.0899186 0.282568
Brugia malayi Phospholipase A2 family protein 0.00701941 0.0175052 0.0257714
Echinococcus multilocularis patatin phospholipase domain containing protein 0.00661528 0.0147296 0.0478021
Echinococcus multilocularis neuropeptides capa receptor 0.00800788 0.0242941 0.0809088
Mycobacterium ulcerans regulatory protein 0.00661528 0.0147296 0.0659638
Echinococcus multilocularis rac serine:threonine kinase 0.00951143 0.0346205 0.116653
Echinococcus granulosus m phase inducer phosphatasecdc25 0.0350034 0.209701 0.722681
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0350034 0.209701 0.796174
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00800788 0.0242941 0.0726461
Onchocerca volvulus Phospholipase A2 homolog 0.00701941 0.0175052 0.00281707
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00800788 0.0242941 0.0809088
Echinococcus multilocularis serotonin receptor 0.00800788 0.0242941 0.0809088
Echinococcus granulosus serine threonine protein kinase nrc 0.00893131 0.0306362 0.102862
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088
Brugia malayi AKH receptor 0.00800788 0.0242941 0.0357663
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0175629 0.0899186 1
Mycobacterium ulcerans transcriptional regulatory protein 0.00661528 0.0147296 0.0659638
Echinococcus granulosus hypothetical protein 0.00800788 0.0242941 0.0809088
Trichomonas vaginalis AGC family protein kinase 0.0140166 0.0655625 0.248301
Echinococcus granulosus neuropeptide s receptor 0.00800788 0.0242941 0.0809088
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.00800788 0.0242941 0.0809088
Mycobacterium tuberculosis Conserved hypothetical protein 0.00661528 0.0147296 0.0461113
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.00661528 0.0147296 0.0130296
Loa Loa (eye worm) neuropeptide F receptor 0.00800788 0.0242941 0.0809088
Trichomonas vaginalis AGC family protein kinase 0.0140166 0.0655625 0.248301
Leishmania major hypothetical protein, conserved 0.00661528 0.0147296 0.0130296
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088
Onchocerca volvulus 0.00800788 0.0242941 0.0097075
Trichomonas vaginalis guanylate cyclase, putative 0.00478437 0.00215479 0.00728778
Trichomonas vaginalis adenylate cyclase type VI, putative 0.00478437 0.00215479 0.00728778
Onchocerca volvulus 0.0350034 0.209701 0.197886
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.00661528 0.0147296 0.0478021
Schistosoma mansoni opsin-like receptor 0.00800788 0.0242941 0.0726461
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0466686 0.289818 0.426676
Entamoeba histolytica PH domain containing protein kinase, putative 0.00951143 0.0346205 0.161417
Echinococcus multilocularis rhodopsin orphan GPCR 0.00800788 0.0242941 0.0809088
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0350034 0.209701 0.796174
Schistosoma mansoni similar to Protein C20orf152 homolog 0.00661528 0.0147296 0.0429203
Echinococcus multilocularis neuropeptide Y receptor 0.00800788 0.0242941 0.0809088
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088
Echinococcus granulosus nervana 2 0.00883198 0.0299541 0.1005
Echinococcus granulosus cGMP dependent protein kinase 1 0.0067146 0.0154118 0.0501633
Echinococcus granulosus 7tm_1 domain containing protein 0.00800788 0.0242941 0.0809088
Trypanosoma brucei telomerase reverse transcriptase 0.0467022 0.290049 1
Trichomonas vaginalis conserved hypothetical protein 0.00478437 0.00215479 0.00728778
Trichomonas vaginalis conserved hypothetical protein 0.00478437 0.00215479 0.00728778
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088
Onchocerca volvulus 0.0350034 0.209701 0.197886
Echinococcus granulosus thyrotropin releasing hormone receptor 0.00800788 0.0242941 0.0809088
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0104727 0.0412225 0.125258
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0350034 0.209701 0.796174
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.00800788 0.0242941 0.0809088
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.00661528 0.0147296 0.0461113
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.00608607 0.0110949 0.710957
Loa Loa (eye worm) G-protein coupled receptor 0.00800788 0.0242941 0.0809088
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0466686 0.289818 1
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.00661528 0.0147296 0.0478021
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.00893131 0.0306362 0.102862
Loa Loa (eye worm) thioredoxin reductase 0.0175629 0.0899186 0.308063
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.00800788 0.0242941 0.0357663
Echinococcus multilocularis rhodopsin orphan GPCR 0.00800788 0.0242941 0.0809088
Echinococcus multilocularis m phase inducer phosphatase(cdc25) 0.0350034 0.209701 0.722681
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.00800788 0.0242941 0.0726461
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.00608607 0.0110949 0.035221
Toxoplasma gondii RNA-directed DNA polymerase 0.0467022 0.290049 1
Giardia lamblia CAMP-dependent protein kinase regulatory chain 0.00661528 0.0147296 0.0130296
Loa Loa (eye worm) AGC/PKG protein kinase 0.0067146 0.0154118 0.0501633
Trichomonas vaginalis AGC family protein kinase 0.0140166 0.0655625 0.248301
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0234291 0.130208 0.191695
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.00661528 0.0147296 0.0414071
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.00800788 0.0242941 0.0809088
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088
Toxoplasma gondii AGC kinase 0.0134365 0.0615782 0.180974
Leishmania major trypanothione reductase 0.0175629 0.0899186 0.282568
Loa Loa (eye worm) hypothetical protein 0.00661528 0.0147296 0.0478021
Echinococcus multilocularis alpha 1A adrenergic receptor 0.00800788 0.0242941 0.0809088
Echinococcus multilocularis hyperpolarization activated cyclic 0.0104727 0.0412225 0.139505
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.00608607 0.0110949 0.0287522
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0234291 0.130208 0.447521
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0467022 0.290049 1
Entamoeba histolytica protein kinase, putative 0.0140166 0.0655625 0.30962
Brugia malayi Protein kinase domain containing protein 0.0140166 0.0655625 0.0965224
Echinococcus multilocularis fmrfamide receptor 0.00800788 0.0242941 0.0809088
Echinococcus multilocularis G-protein coupled receptor, putative 0.00800788 0.0242941 0.0809088
Echinococcus multilocularis voltage gated potassium channel 0.0152571 0.0740819 0.253245
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.00800788 0.0242941 0.0809088
Echinococcus granulosus serotonin receptor 0.00800788 0.0242941 0.0809088
Echinococcus multilocularis rhodopsin orphan GPCR 0.00800788 0.0242941 0.0809088
Brugia malayi putative neuropeptide receptor 0.00800788 0.0242941 0.0357663
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.00661528 0.0147296 0.0429203
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.00661528 0.0147296 0.0429203
Trypanosoma cruzi rac serine-threonine kinase, putative 0.00893131 0.0306362 0.070052
Brugia malayi protein kinase C II. 0.00460453 0.000919629 0.0013539
Plasmodium vivax phosphoethanolamine N-methyltransferase 0.0150315 0.0725325 0.220243
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.00883198 0.0299541 0.1005
Schistosoma mansoni neuropeptide f receptor 76f 0.00800788 0.0242941 0.0726461
Echinococcus multilocularis somatostatin receptor 0.00800788 0.0242941 0.0809088
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0428112 0.263325 1
Echinococcus granulosus g protein coupled receptor 0.00800788 0.0242941 0.0809088
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.00661528 0.0147296 0.0130296
Echinococcus multilocularis rhodopsin orphan GPCR 0.00800788 0.0242941 0.0809088
Trichomonas vaginalis AGC family protein kinase 0.0140166 0.0655625 0.248301
Schistosoma mansoni voltage-gated potassium channel 0.0152571 0.0740819 0.227383
Trichomonas vaginalis guanylate cyclase, putative 0.00478437 0.00215479 0.00728778
Trichomonas vaginalis adenylate cyclase, putative 0.00478437 0.00215479 0.00728778
Onchocerca volvulus 0.00800788 0.0242941 0.0097075
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.00800788 0.0242941 0.0809088
Trichomonas vaginalis conserved hypothetical protein 0.00478437 0.00215479 0.00728778
Trichomonas vaginalis conserved hypothetical protein 0.00478437 0.00215479 0.00728778
Echinococcus granulosus fmrfamide receptor 0.00800788 0.0242941 0.0809088
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0104727 0.0412225 0.139505
Toxoplasma gondii thioredoxin reductase 0.0175629 0.0899186 0.282568
Echinococcus granulosus g protein coupled receptor 0.00800788 0.0242941 0.0809088
Trichomonas vaginalis guanylate cyclase, putative 0.00478437 0.00215479 0.00728778
Mycobacterium ulcerans transmembrane transport protein 0.00661528 0.0147296 0.0659638
Mycobacterium ulcerans hypothetical protein 0.00661528 0.0147296 0.0659638
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.00661528 0.0147296 0.0429203
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0104727 0.0412225 0.139505
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.00800788 0.0242941 0.0809088
Echinococcus multilocularis neuropeptide receptor 0.00800788 0.0242941 0.0809088
Brugia malayi Protein kinase domain containing protein 0.00460453 0.000919629 0.0013539
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.00608607 0.0110949 0.0287522
Trichomonas vaginalis cdc25b, putative 0.0350034 0.209701 0.796174
Echinococcus granulosus thioredoxin glutathione reductase 0.0175629 0.0899186 0.308063
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088
Onchocerca volvulus 0.00800788 0.0242941 0.0097075
Trichomonas vaginalis mercuric reductase, putative 0.00608607 0.0110949 0.0412693
Trichomonas vaginalis AGC family protein kinase 0.00518464 0.0049039 0.0177372
Trichomonas vaginalis conserved hypothetical protein 0.00478437 0.00215479 0.00728778
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.00800788 0.0242941 0.0357663
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0104727 0.0412225 0.139505
Echinococcus granulosus Glutaredoxin protein 5 0.00883198 0.0299541 0.1005
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.00800788 0.0242941 0.0726461
Trichomonas vaginalis adenylate cyclase type vIII, putative 0.00478437 0.00215479 0.00728778
Loa Loa (eye worm) glutathione reductase 0.0175629 0.0899186 0.308063
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.00661528 0.0147296 0.0429203
Leishmania major telomerase reverse transcriptase, putative 0.0467022 0.290049 1
Trichomonas vaginalis guanylate cyclase, putative 0.00478437 0.00215479 0.00728778
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088
Trichomonas vaginalis adenylate cyclase type III, putative 0.00478437 0.00215479 0.00728778
Brugia malayi neuropeptide F receptor 0.00800788 0.0242941 0.0357663
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.00661528 0.0147296 0.0429203
Trichomonas vaginalis guanylate cyclase beta 1 subunit, putative 0.00478437 0.00215479 0.00728778
Brugia malayi hypothetical protein 0.00800788 0.0242941 0.0357663
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.00661528 0.0147296 0.0550847
Schistosoma mansoni opsin-like receptor 0.00800788 0.0242941 0.0726461
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088
Plasmodium vivax thioredoxin reductase, putative 0.0175629 0.0899186 0.282568
Trichomonas vaginalis adenylate cyclase type, putative 0.00478437 0.00215479 0.00728778
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.00661528 0.0147296 0.0478021
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0152571 0.0740819 0.109065
Mycobacterium ulcerans hypothetical protein 0.00661528 0.0147296 0.0659638
Brugia malayi putative neuropeptide receptor NPR1 0.00800788 0.0242941 0.0357663
Onchocerca volvulus 0.00800788 0.0242941 0.0097075
Loa Loa (eye worm) hypothetical protein 0.0350034 0.209701 0.722681
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0104727 0.0412225 0.125258
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.00661528 0.0147296 0.0216852
Echinococcus granulosus neuropeptide Y receptor 0.00800788 0.0242941 0.0809088
Schistosoma mansoni biogenic amine (5HT) receptor 0.00800788 0.0242941 0.0726461
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.00608607 0.0110949 0.0287522
Leishmania major hypothetical protein, conserved 0.00661528 0.0147296 0.0130296
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00800788 0.0242941 0.0726461
Brugia malayi Rhodanese-like domain containing protein 0.0350034 0.209701 0.308726
Echinococcus granulosus rhodopsin orphan GPCR 0.00800788 0.0242941 0.0809088
Trichomonas vaginalis guanylate cyclase, putative 0.00478437 0.00215479 0.00728778
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088
Echinococcus multilocularis neuropeptide FF receptor 2 0.00800788 0.0242941 0.0809088
Echinococcus granulosus tm gpcr rhodopsin 0.00800788 0.0242941 0.0809088
Echinococcus multilocularis hyperpolarization activated cyclic 0.0104727 0.0412225 0.139505
Mycobacterium ulcerans methyltransferase 0.0141088 0.0661958 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.00800788 0.0242941 0.0809088
Trichomonas vaginalis adenylate cyclase, putative 0.00478437 0.00215479 0.00728778
Trypanosoma cruzi rac serine-threonine kinase, putative 0.00951143 0.0346205 0.0843349
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00800788 0.0242941 0.0726461
Leishmania major protein kinase, putative 0.0067146 0.0154118 0.015475
Brugia malayi G protein-coupled receptor F59B2.13 0.00800788 0.0242941 0.0357663
Echinococcus multilocularis allatostatin A receptor 0.00800788 0.0242941 0.0809088
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00800788 0.0242941 0.0809088
Plasmodium falciparum phosphoethanolamine N-methyltransferase 0.0150315 0.0725325 0.220243
Trichomonas vaginalis hypothetical protein 0.00478437 0.00215479 0.00728778
Trichomonas vaginalis cdc25b, putative 0.0350034 0.209701 0.796174
Brugia malayi Thioredoxin reductase 0.0175629 0.0899186 0.13238
Trichomonas vaginalis adenylate cyclase, putative 0.00478437 0.00215479 0.00728778
Loa Loa (eye worm) AGC/AKT protein kinase 0.0140166 0.0655625 0.223756
Onchocerca volvulus 0.00800788 0.0242941 0.0097075
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.00661528 0.0147296 0.0461113
Brugia malayi Egg laying defective protein 4 0.0067146 0.0154118 0.0226895
Onchocerca volvulus 0.00800788 0.0242941 0.0097075
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088
Brugia malayi Protein kinase domain containing protein 0.00460453 0.000919629 0.0013539
Trichomonas vaginalis AGC family protein kinase 0.0140166 0.0655625 0.248301
Trichomonas vaginalis guanylate cyclase, putative 0.00478437 0.00215479 0.00728778
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.00478437 0.00215479 0.00728778
Plasmodium falciparum thioredoxin reductase 0.0175629 0.0899186 0.282568
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.00661528 0.0147296 0.0478021
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.00800788 0.0242941 0.0809088
Schistosoma mansoni biogenic amine receptor 0.00800788 0.0242941 0.0726461
Echinococcus multilocularis neuropeptide receptor 0.00800788 0.0242941 0.0809088
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.00661528 0.0147296 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.00800788 0.0242941 0.0809088
Mycobacterium tuberculosis Possible methyltransferase (methylase) 0.0141088 0.0661958 0.69904
Trichomonas vaginalis adenylate cyclase, putative 0.00478437 0.00215479 0.00728778
Trichomonas vaginalis AGC family protein kinase 0.0140166 0.0655625 0.248301
Trichomonas vaginalis conserved hypothetical protein 0.00478437 0.00215479 0.00728778
Brugia malayi Serotonin receptor 0.00800788 0.0242941 0.0357663
Schistosoma mansoni hypothetical protein 0.00661528 0.0147296 0.0429203
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.00661528 0.0147296 0.0130296
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.00893131 0.0306362 0.102862
Schistosoma mansoni serine/threonine protein kinase 0.0067146 0.0154118 0.0450404
Trichomonas vaginalis guanylate cyclase, putative 0.00478437 0.00215479 0.00728778
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.00800788 0.0242941 0.0726461
Schistosoma mansoni biogenic amine receptor 0.00800788 0.0242941 0.0726461
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088
Schistosoma mansoni opsin-like receptor 0.00800788 0.0242941 0.0726461
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.00661528 0.0147296 0.0130296
Plasmodium falciparum telomerase reverse transcriptase 0.0467022 0.290049 1
Trypanosoma brucei rac serine-threonine kinase, putative 0.0140166 0.0655625 0.218395
Brugia malayi N-terminal motif family protein 0.00661528 0.0147296 0.0216852
Echinococcus multilocularis orexin receptor type 2 0.00800788 0.0242941 0.0809088
Trypanosoma cruzi Protein kinase B 0.00951143 0.0346205 0.0843349
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088
Trichomonas vaginalis guanylate cyclase, putative 0.00478437 0.00215479 0.00728778
Loa Loa (eye worm) hypothetical protein 0.0320784 0.189612 0.653144
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0104727 0.0412225 0.155785
Trichomonas vaginalis cdc25c, putative 0.0350034 0.209701 0.796174
Echinococcus granulosus rhodopsin orphan GPCR 0.00800788 0.0242941 0.0809088
Brugia malayi larval opioid receptor 0.00800788 0.0242941 0.0357663
Echinococcus multilocularis rhodopsin orphan GPCR 0.00800788 0.0242941 0.0809088
Schistosoma mansoni growth hormone secretagogue receptor 0.00800788 0.0242941 0.0726461
Echinococcus multilocularis nervana 2 0.00883198 0.0299541 0.1005
Trichomonas vaginalis guanylate cyclase, putative 0.00478437 0.00215479 0.00728778
Schistosoma mansoni amine GPCR 0.00800788 0.0242941 0.0726461
Trichomonas vaginalis guanylate cyclase, putative 0.00478437 0.00215479 0.00728778
Trichomonas vaginalis guanylate cyclase beta 2 subunit, putative 0.00478437 0.00215479 0.00728778
Brugia malayi hypothetical protein 0.00800788 0.0242941 0.0357663
Schistosoma mansoni serine/threonine protein kinase 0.0067146 0.0154118 0.0450404
Schistosoma mansoni amine GPCR 0.00800788 0.0242941 0.0726461
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.00800788 0.0242941 0.0809088
Trichomonas vaginalis adenylate cyclase, putative 0.00478437 0.00215479 0.00728778
Loa Loa (eye worm) hypothetical protein 0.0152571 0.0740819 0.253245
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088
Onchocerca volvulus 0.00800788 0.0242941 0.0097075
Echinococcus granulosus 7TM GPCR rhodopsin 0.00800788 0.0242941 0.0809088
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088
Trichomonas vaginalis adenylate cyclase type IX, putative 0.00478437 0.00215479 0.00728778
Echinococcus multilocularis expressed conserved protein 0.0067146 0.0154118 0.0501633
Brugia malayi hypothetical protein 0.00800788 0.0242941 0.0357663
Trypanosoma brucei Flagellar Member 6 0.00661528 0.0147296 0.0414071
Echinococcus granulosus neuropeptide receptor A26 0.00800788 0.0242941 0.0809088
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.00478437 0.00215479 0.00728778
Leishmania major regulatory subunit of protein kinase a-like protein 0.00661528 0.0147296 0.0130296
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088
Onchocerca volvulus 0.00800788 0.0242941 0.0097075
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.00661528 0.0147296 0.0130296
Echinococcus granulosus sex peptide receptor 0.00800788 0.0242941 0.0809088
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.00661528 0.0147296 0.0429203
Echinococcus multilocularis nervana 2 0.00883198 0.0299541 0.1005
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.00661528 0.0147296 0.0550847
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.00800788 0.0242941 0.0809088
Giardia lamblia Kinase, AGC PKA 0.00893131 0.0306362 0.070052
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0104727 0.0412225 0.139505
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.00478437 0.00215479 0.00728778
Onchocerca volvulus 0.00800788 0.0242941 0.0097075
Onchocerca volvulus Phospholipase A2 homolog 0.00701941 0.0175052 0.00281707
Schistosoma mansoni neuropeptide F-like receptor 0.00800788 0.0242941 0.0726461
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0234291 0.130208 0.447521
Echinococcus granulosus rhodopsin orphan GPCR 0.00800788 0.0242941 0.0809088
Echinococcus granulosus patatin phospholipase domain containing protein 0.00661528 0.0147296 0.0478021
Echinococcus multilocularis sex peptide receptor 0.00800788 0.0242941 0.0809088
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088
Schistosoma mansoni hypothetical protein 0.00800788 0.0242941 0.0726461
Plasmodium falciparum cGMP-dependent protein kinase 0.0067146 0.0154118 0.015475
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088
Brugia malayi sulfakinin receptor protein 0.00800788 0.0242941 0.0357663
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088
Mycobacterium ulcerans hypothetical protein 0.00661528 0.0147296 0.0659638
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.00478437 0.00215479 0.00728778
Trypanosoma brucei cAMP binding protein, putative 0.00661528 0.0147296 0.0414071
Trichomonas vaginalis glutathione reductase, putative 0.00608607 0.0110949 0.0412693
Brugia malayi Rhodanese-like domain containing protein 0.0350034 0.209701 0.308726
Leishmania major hypothetical protein, unknown function 0.00661528 0.0147296 0.0130296
Trichomonas vaginalis adenylate cyclase type IX, putative 0.00478437 0.00215479 0.00728778
Echinococcus granulosus cGMP dependent protein kinase 0.0067146 0.0154118 0.0501633
Echinococcus granulosus biogenic amine 5HT receptor 0.00800788 0.0242941 0.0809088
Trichomonas vaginalis AGC family protein kinase 0.00460453 0.000919629 0.00259291
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.00661528 0.0147296 0.0130296
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00800788 0.0242941 0.0726461
Schistosoma mansoni histamine h1 receptor 0.00800788 0.0242941 0.0726461
Trichomonas vaginalis adenylate cyclase type IX, putative 0.00478437 0.00215479 0.00728778
Trichomonas vaginalis conserved hypothetical protein 0.00478437 0.00215479 0.00728778
Echinococcus granulosus g-protein coupled receptor 0.00800788 0.0242941 0.0809088
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.00478437 0.00215479 0.00728778
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0428112 0.263325 1
Trichomonas vaginalis guanylate cyclase, putative 0.00478437 0.00215479 0.00728778
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088
Trichomonas vaginalis guanylate cyclase, putative 0.00478437 0.00215479 0.00728778
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.00800788 0.0242941 0.0809088
Trichomonas vaginalis adenylate cyclase, putative 0.00478437 0.00215479 0.00728778
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.00800788 0.0242941 0.0809088
Echinococcus granulosus neuropeptides capa receptor 0.00800788 0.0242941 0.0809088
Trichomonas vaginalis guanylate cyclase, putative 0.00478437 0.00215479 0.00728778
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088
Trichomonas vaginalis conserved hypothetical protein 0.00478437 0.00215479 0.00728778
Echinococcus granulosus cyclic nucleotide gated cation channel 0.00661528 0.0147296 0.0478021
Echinococcus multilocularis G protein coupled receptor 139 0.00800788 0.0242941 0.0809088
Onchocerca volvulus 0.00800788 0.0242941 0.0097075
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.00478437 0.00215479 0.00728778
Echinococcus granulosus dro:myosuppressin receptor 0.00800788 0.0242941 0.0809088
Schistosoma mansoni neuropeptide receptor 0.00800788 0.0242941 0.0726461
Schistosoma mansoni hypothetical protein 0.00478437 0.00215479 0.0038388
Trichomonas vaginalis conserved hypothetical protein 0.00478437 0.00215479 0.00728778
Brugia malayi Serotonin/octopamine receptor family protein 7 0.00800788 0.0242941 0.0357663
Treponema pallidum cyclic nucleotide binding protein 0.00661528 0.0147296 1
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.00661528 0.0147296 0.0429203
Trichomonas vaginalis adenylyl cyclase type V, putative 0.00478437 0.00215479 0.00728778
Schistosoma mansoni adenoreceptor 0.00800788 0.0242941 0.0726461
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088
Schistosoma mansoni neuropeptide receptor 0.00800788 0.0242941 0.0726461
Trichomonas vaginalis guanylate cyclase, putative 0.00478437 0.00215479 0.00728778
Echinococcus granulosus neuropeptide Y receptor 0.00800788 0.0242941 0.0809088
Brugia malayi G protein-coupled receptor 0.00800788 0.0242941 0.0357663
Trichomonas vaginalis adenylate cyclase type, putative 0.00478437 0.00215479 0.00728778
Leishmania major protein kinase A regulatory subunit, putative 0.00661528 0.0147296 0.0130296
Trichomonas vaginalis adenylate cyclase type, putative 0.00478437 0.00215479 0.00728778
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0104727 0.0412225 0.155785
Echinococcus granulosus neuropeptides capa receptor 0.00800788 0.0242941 0.0809088
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.00661528 0.0147296 0.0130296
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.00661528 0.0147296 0.0130296
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.00661528 0.0147296 0.0429203
Schistosoma mansoni biogenic amine receptor 0.00800788 0.0242941 0.0726461
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.00661528 0.0147296 0.0130296
Brugia malayi follicle stimulating hormone receptor 0.00800788 0.0242941 0.0357663
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00800788 0.0242941 0.0726461
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0134365 0.0615782 0.209965
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0234291 0.130208 0.447521
Trypanosoma cruzi Flagellar Member 6 0.00661528 0.0147296 0.0130296
Trypanosoma cruzi cAMP binding protein, putative 0.00661528 0.0147296 0.0130296
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.00478437 0.00215479 0.00728778
Onchocerca volvulus 0.00800788 0.0242941 0.0097075
Trypanosoma cruzi cAMP response protein 1 0.00661528 0.0147296 0.0130296
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088
Entamoeba histolytica PH domain containing protein kinase, putative 0.00951143 0.0346205 0.161417
Trypanosoma cruzi protein kinase A regulatory subunit 0.00661528 0.0147296 0.0130296
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0104727 0.0412225 0.139505
Echinococcus granulosus rhodopsin orphan GPCR 0.00800788 0.0242941 0.0809088
Trypanosoma brucei protein kinase A regulatory subunit 0.00661528 0.0147296 0.0414071
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.00661528 0.0147296 0.0429203
Trichomonas vaginalis adenylate cyclase, putative 0.00478437 0.00215479 0.00728778
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.00478437 0.00215479 0.00728778
Echinococcus granulosus biogenic amine 5HT receptor 0.00800788 0.0242941 0.0809088
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.00800788 0.0242941 0.0809088
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.00661528 0.0147296 0.0478021
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.00800788 0.0242941 0.0357663
Echinococcus multilocularis neuropeptide s receptor 0.00800788 0.0242941 0.0809088
Schistosoma mansoni hypothetical protein 0.00800788 0.0242941 0.0726461
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088
Schistosoma mansoni voltage-gated potassium channel 0.00864178 0.0286477 0.0861768
Trichomonas vaginalis guanylate cyclase, putative 0.00478437 0.00215479 0.00728778
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.00661528 0.0147296 0.0216852
Schistosoma mansoni voltage-gated potassium channel 0.051453 0.322678 1
Leishmania major protein kinase, putative 0.0067146 0.0154118 0.015475
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0234291 0.130208 0.447521
Entamoeba histolytica rodhanase-like domain containing protein 0.0350034 0.209701 1
Entamoeba histolytica protein kinase, putative 0.0134365 0.0615782 0.290536
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.00478437 0.00215479 0.00728778
Schistosoma mansoni hypothetical protein 0.00800788 0.0242941 0.0726461
Brugia malayi neuropeptide F receptor 0.00800788 0.0242941 0.0357663
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0104727 0.0412225 0.125258
Leishmania major cyclic nucleotide-binding protein-like protein 0.00661528 0.0147296 0.0130296
Loa Loa (eye worm) hypothetical protein 0.0104727 0.0412225 0.139505
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00800788 0.0242941 0.0726461
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088
Loa Loa (eye worm) melatonin receptor type 1A 0.00800788 0.0242941 0.0809088
Trichomonas vaginalis adenylate cyclase, putative 0.00478437 0.00215479 0.00728778
Treponema pallidum catabolite gene activator 0.00661528 0.0147296 1
Onchocerca volvulus 0.0350034 0.209701 0.197886
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.00608607 0.0110949 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.00800788 0.0242941 0.0809088
Trichomonas vaginalis adenylate cyclase, putative 0.00478437 0.00215479 0.00728778
Echinococcus multilocularis rhodopsin orphan GPCR 0.00800788 0.0242941 0.0809088
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00800788 0.0242941 0.0726461
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.00661528 0.0147296 0.0478021
Loa Loa (eye worm) TYRA-2 protein 0.00800788 0.0242941 0.0809088
Echinococcus multilocularis rhodopsin orphan GPCR 0.00800788 0.0242941 0.0809088
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0350034 0.209701 0.796174
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.00478437 0.00215479 0.00728778
Schistosoma mansoni peptide (allatostatin)-like receptor 0.00800788 0.0242941 0.0726461
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.00661528 0.0147296 0.0414071
Echinococcus multilocularis g protein coupled receptor 0.00800788 0.0242941 0.0809088
Echinococcus granulosus hyperpolarization activated cyclic 0.0104727 0.0412225 0.139505
Brugia malayi GnHR receptor homolog 0.00800788 0.0242941 0.0357663
Onchocerca volvulus Neuropeptide F receptor homolog 0.00800788 0.0242941 0.0097075
Echinococcus granulosus hyperpolarization activated cyclic 0.0104727 0.0412225 0.139505
Echinococcus granulosus tm gpcr rhodopsin 0.00800788 0.0242941 0.0809088
Echinococcus granulosus rhodopsin orphan GPCR 0.00800788 0.0242941 0.0809088
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.00800788 0.0242941 0.0726461
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.00608607 0.0110949 0.0163342
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.00800788 0.0242941 0.0809088
Trypanosoma brucei cAMP response protein 1, putative 0.00661528 0.0147296 0.0414071
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.00661528 0.0147296 0.0550847
Echinococcus granulosus somatostatin receptor 0.00800788 0.0242941 0.0809088
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088
Echinococcus multilocularis g-protein coupled receptor 0.00800788 0.0242941 0.0809088
Trypanosoma brucei trypanothione reductase 0.0175629 0.0899186 0.303196
Brugia malayi hypothetical protein 0.00800788 0.0242941 0.0357663
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0234291 0.130208 0.447521
Schistosoma mansoni neuropeptide receptor 0.00800788 0.0242941 0.0726461
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.00661528 0.0147296 0.0429203
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.0350034 0.209701 0.648878
Onchocerca volvulus 0.00800788 0.0242941 0.0097075
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.00478437 0.00215479 0.00317233
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0067146 0.0154118 0.0501633
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.00661528 0.0147296 0.0478021
Trichomonas vaginalis adenylate cyclase type III, putative 0.00478437 0.00215479 0.00728778
Brugia malayi G-protein coupled receptor 0.00800788 0.0242941 0.0357663
Brugia malayi Hr1 repeat family protein 0.00460453 0.000919629 0.0013539
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0467022 0.290049 1
Schistosoma mansoni amine GPCR 0.00800788 0.0242941 0.0726461
Brugia malayi Dopamine receptor 0.00800788 0.0242941 0.0357663
Echinococcus granulosus neuropeptide receptor 0.00800788 0.0242941 0.0809088
Mycobacterium ulcerans mycolic acid synthase UmaA 0.0141088 0.0661958 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00800788 0.0242941 0.0726461
Schistosoma mansoni biogenic amine (5HT) receptor 0.00800788 0.0242941 0.0726461
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0104727 0.0412225 0.139505
Brugia malayi hypothetical protein 0.00800788 0.0242941 0.0357663
Echinococcus multilocularis thioredoxin glutathione reductase 0.0175629 0.0899186 0.308063
Brugia malayi G-protein coupled receptor 0.00800788 0.0242941 0.0357663
Echinococcus multilocularis Glutaredoxin protein 5 0.00883198 0.0299541 0.1005
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.00893131 0.0306362 0.070052
Echinococcus multilocularis neuropeptides capa receptor 0.00800788 0.0242941 0.0809088
Plasmodium vivax telomerase reverse transcriptase, putative 0.0467022 0.290049 1
Trichomonas vaginalis adenylate cyclase type IX, putative 0.00478437 0.00215479 0.00728778
Trichomonas vaginalis guanylate cyclase, putative 0.00478437 0.00215479 0.00728778
Loa Loa (eye worm) hypothetical protein 0.00701941 0.0175052 0.0574095
Giardia lamblia Telomerase catalytic subunit 0.0467022 0.290049 1
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088
Trichomonas vaginalis AGC family protein kinase 0.00460453 0.000919629 0.00259291
Schistosoma mansoni myosin xvIII 0.00800788 0.0242941 0.0726461
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.00800788 0.0242941 0.0726461
Schistosoma mansoni hypothetical protein 0.00800788 0.0242941 0.0726461
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.00800788 0.0242941 0.0809088
Onchocerca volvulus 0.00800788 0.0242941 0.0097075
Echinococcus granulosus G protein coupled receptor 139 0.00800788 0.0242941 0.0809088
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.00800788 0.0242941 0.0097075
Schistosoma mansoni amine GPCR 0.00800788 0.0242941 0.0726461
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00800788 0.0242941 0.0809088
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.00800788 0.0242941 0.0809088
Trichomonas vaginalis adenylate cyclase, putative 0.00478437 0.00215479 0.00728778
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.00800788 0.0242941 0.0809088
Brugia malayi p70 ribosomal S6 kinase beta 0.0134365 0.0615782 0.0906567
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088
Leishmania major hypothetical protein, conserved 0.00661528 0.0147296 0.0130296
Onchocerca volvulus 0.0350034 0.209701 0.197886
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0466686 0.289818 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.00608607 0.0110949 0.035221
Schistosoma mansoni voltage-gated potassium channel 0.0104727 0.0412225 0.125258
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.00661528 0.0147296 0.0461113
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.00478437 0.00215479 0.00728778
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088
Echinococcus granulosus neuropeptide FF receptor 2 0.00800788 0.0242941 0.0809088
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.00800788 0.0242941 0.0809088
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0067146 0.0154118 0.015475
Schistosoma mansoni serine/threonine-protein kinase 0.00951143 0.0346205 0.10474
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.00893131 0.0306362 0.070052
Trichomonas vaginalis guanylate cyclase, putative 0.00478437 0.00215479 0.00728778
Loa Loa (eye worm) follicle stimulating hormone receptor 0.00800788 0.0242941 0.0809088
Echinococcus granulosus orexin receptor type 2 0.00800788 0.0242941 0.0809088
Echinococcus multilocularis serotonin receptor 0.00800788 0.0242941 0.0809088
Trichomonas vaginalis adenylate cyclase, putative 0.00478437 0.00215479 0.00728778
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088
Brugia malayi hypothetical protein 0.00800788 0.0242941 0.0357663
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0152571 0.0740819 0.253245
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.00661528 0.0147296 0.0461113
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.00800788 0.0242941 0.0726461
Trypanosoma cruzi cAMP response protein 1, putative 0.00661528 0.0147296 0.0130296
Brugia malayi hypothetical protein 0.00800788 0.0242941 0.0357663
Schistosoma mansoni serine/threonine-protein kinase 0.00951143 0.0346205 0.10474
Trichomonas vaginalis adenylate cyclase, putative 0.00478437 0.00215479 0.00728778
Trypanosoma cruzi trypanothione reductase, putative 0.0175629 0.0899186 0.282568
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0104727 0.0412225 0.125258
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0104727 0.0412225 0.139505
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0234291 0.130208 0.401818
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0152571 0.0740819 0.253245
Loa Loa (eye worm) hypothetical protein 0.0350034 0.209701 0.722681
Loa Loa (eye worm) neuropeptide F receptor 0.00800788 0.0242941 0.0809088
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088
Trichomonas vaginalis adenylate cyclase, putative 0.00478437 0.00215479 0.00728778
Treponema pallidum cyclic nucleotide binding protein 0.00661528 0.0147296 1
Entamoeba histolytica protein kinase 2, putative 0.00893131 0.0306362 0.142333
Schistosoma mansoni 60S ribosomal protein L21 0.00864178 0.0286477 0.0861768
Trichomonas vaginalis intestinal guanylate cyclase, putative 0.00478437 0.00215479 0.00728778
Loa Loa (eye worm) hypothetical protein 0.0400533 0.244384 0.842733
Echinococcus multilocularis g protein coupled receptor 0.00800788 0.0242941 0.0809088
Entamoeba histolytica rodhanase-like domain containing protein 0.0350034 0.209701 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.00661528 0.0147296 0.0550847
Brugia malayi hypothetical protein 0.00800788 0.0242941 0.0357663
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.00478437 0.00215479 0.00728778
Echinococcus multilocularis fmrfamide receptor 0.00800788 0.0242941 0.0809088
Loa Loa (eye worm) hypothetical protein 0.00661528 0.0147296 0.0478021
Loa Loa (eye worm) G-protein coupled receptor 0.00800788 0.0242941 0.0809088
Echinococcus multilocularis biogenic amine (5HT) receptor 0.00800788 0.0242941 0.0809088
Trichomonas vaginalis adenylate cyclase, putative 0.00478437 0.00215479 0.00728778
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.150072 1 1
Treponema pallidum catabolite gene activator (Crp) 0.00661528 0.0147296 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00800788 0.0242941 0.0726461
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.00478437 0.00215479 0.00728778
Brugia malayi Telomerase reverse transcriptase 0.10337 0.679246 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00800788 0.0242941 0.0726461
Echinococcus granulosus tachykinin peptides receptor 99D 0.00800788 0.0242941 0.0809088
Echinococcus granulosus nervana 2 0.00883198 0.0299541 0.1005
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088
Brugia malayi Serotonin receptor 0.00800788 0.0242941 0.0357663
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.00661528 0.0147296 0.0216852
Echinococcus multilocularis neuropeptide receptor A26 0.00800788 0.0242941 0.0809088
Loa Loa (eye worm) hypothetical protein 0.00800788 0.0242941 0.0809088

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.18 ug ml-1 Antiinfective activity against Plasmodium falciparum D6 infected red blood cells ChEMBL. 17134906
IC50 (functional) = 0.2 ug ml-1 Antiinfective activity against Plasmodium falciparum W2 in red blood cells ChEMBL. 17134906
IC50 (functional) = 0.2 ug ml-1 Antiinfective activity against Plasmodium falciparum W2 in red blood cells ChEMBL. 17134906
IC50 (functional) = 3 ug ml-1 Antileishmanial activity against Leishmania donovani promastigotes ChEMBL. 17134906
IC50 (functional) = 3 ug ml-1 Antileishmanial activity against Leishmania donovani promastigotes ChEMBL. 17134906
IC50 (functional) = 15 ug ml-1 Antibacterial activity against Mycobacterium intracellulare ATCC 23068 ChEMBL. 17134906
IC50 (ADMET) > 23.8 ug ml-1 Cytotoxicity against Vero cells ChEMBL. 17134906
MIC (functional) > 20 ug ml-1 Antifungal activity against Cryptococcus neoformans ATCC 90113 ChEMBL. 17134906
MIC (functional) > 20 ug ml-1 Antifungal activity against Candida albicans ATCC 90028 ChEMBL. 17134906
MIC (functional) > 20 ug ml-1 Antibacterial activity against Aspergillus fumigatus ATCC 90906 ChEMBL. 17134906
MIC (functional) > 20 ug ml-1 Antifungal activity against Cryptococcus neoformans ATCC 90113 ChEMBL. 17134906
MIC (functional) > 20 ug ml-1 Antifungal activity against Candida albicans ATCC 90028 ChEMBL. 17134906

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 17134906
Leishmania donovani ChEMBL23 17134906

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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