Detailed information for compound 424861

Basic information

Technical information
  • TDR Targets ID: 424861
  • Name: 1-methyl-2-[(E)-2-phenylethenyl]benzimidazole
  • MW: 234.296 | Formula: C16H14N2
  • H donors: 0 H acceptors: 1 LogP: 3.74 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cn1c(/C=C/c2ccccc2)nc2c1cccc2
  • InChi: 1S/C16H14N2/c1-18-15-10-6-5-9-14(15)17-16(18)12-11-13-7-3-2-4-8-13/h2-12H,1H3/b12-11+
  • InChiKey: QDZVXONVFRIVPN-VAWYXSNFSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-methyl-2-[(E)-styryl]benzimidazole
  • 1-methyl-2-(2-phenylethenyl)benzimidazole
  • 1-methyl-2-(2-phenylvinyl)benzimidazole
  • 1-methyl-2-[(E)-2-phenylvinyl]benzimidazole
  • 1-Methyl-2-styryl-1H-benzoimidazole
  • BAS 06347392
  • STOCK3S-48001
  • ZINC04003246
  • MLS000718372
  • SMR000290640

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Photuris pennsylvanica Luciferase Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens pyruvate kinase, muscle Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Leishmania mexicana pyruvate kinase, putative Starlite/ChEMBL No references
Human herpesvirus 4 (strain B95-8) Latent membrane protein 1 Starlite/ChEMBL No references
Human immunodeficiency virus 1 Aberrant vpr protein Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium berghei pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Entamoeba histolytica pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania mexicana pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei pyruvate kinase 1 Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum ko:K00873 pyruvate kinase [EC2.7.1.40], putative Get druggable targets OG5_126685 All targets in OG5_126685
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium leprae Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Babesia bovis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum Pyruvate kinase isozyme R, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Giardia lamblia Pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma congolense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Neospora caninum Pyruvate kinase (EC 2.7.1.40), related Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pyruvate kinase, muscle isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium parvum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium falciparum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Toxoplasma gondii pyruvate kinase PyK1 Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pyruvate kinase, M2 isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium knowlesi pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) pyruvate kinase-PB Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Plasmodium vivax long-chain fatty acid CoA ligase, putative Luciferase   552 aa 453 aa 24.5 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferase   552 aa 491 aa 23.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Schistosoma mansoni long-chain-fatty-acid--CoA ligase Luciferase   552 aa 526 aa 22.2 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Theileria parva acetyl-coenzyme A synthetase, putative Luciferase   552 aa 580 aa 22.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Onchocerca volvulus Luciferase   552 aa 553 aa 24.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferase   552 aa 468 aa 20.5 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferase   552 aa 451 aa 22.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferase   552 aa 510 aa 23.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) Luciferase   552 aa 512 aa 22.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Neospora caninum hypothetical protein Luciferase   552 aa 529 aa 22.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Brugia malayi AMP-binding enzyme family protein Luciferase   552 aa 492 aa 24.8 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferase   552 aa 481 aa 25.6 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium tuberculosis Long-chain-fatty-acid-CoA ligase FadD15 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferase   552 aa 483 aa 23.6 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferase   552 aa 476 aa 25.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative Luciferase   552 aa 544 aa 21.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferase   552 aa 470 aa 25.1 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Babesia bovis acetyl-CoA synthetase, putative Luciferase   552 aa 545 aa 21.3 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Giardia lamblia Long chain fatty acid CoA ligase 5 Luciferase   552 aa 491 aa 21.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferase   552 aa 481 aa 20.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Leishmania mexicana long-chain-fatty-acid-CoA ligase, putative,acyl-CoA synthetase, putative,fatty acid thiokinase (long chain), putative Luciferase   552 aa 472 aa 21.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferase   552 aa 481 aa 23.7 %
Echinococcus granulosus pyruvate kinase pyruvate kinase, putative 498 aa 515 aa 27.6 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Echinococcus granulosus pyruvate kinase pyruvate kinase, muscle 605 aa 521 aa 34.9 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus cpg binding protein 0.0037 0.0269 0.0315
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0017 0.0064 0.0074
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0057 0.0482 0.6344
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0017 0.0134
Schistosoma mansoni amine GPCR 0.0013 0.0027 0.0013
Brugia malayi Dopamine receptor 0.0013 0.0027 0.0242
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0013 0.0027 0.0026
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0017 0.0015
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Loa Loa (eye worm) hypothetical protein 0.0043 0.0332 0.2923
Schistosoma mansoni pyruvate kinase 0.0041 0.0318 0.0355
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0017 0.0064 0.0354
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0017 0.0015
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Brugia malayi Serotonin receptor 0.0013 0.0027 0.0242
Schistosoma mansoni pyruvate kinase 0.0081 0.0722 0.0833
Loa Loa (eye worm) hypothetical protein 0.0043 0.0332 0.2923
Echinococcus granulosus neuropeptide receptor A26 0.0013 0.0027 0.0031
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0013 0.0027 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0017 0.0147
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0017 0.0134
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0569 0.1139
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0417 0.3674
Echinococcus granulosus g protein coupled receptor 0.0013 0.0027 0.0031
Trypanosoma brucei pyruvate kinase 1 0.0081 0.0722 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.1118 1
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0017 0.0018
Schistosoma mansoni tar DNA-binding protein 0.0076 0.068 0.0783
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0017 0.0015
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Brugia malayi hypothetical protein 0.0013 0.0027 0.0242
Echinococcus granulosus neuropeptide Y receptor 0.0013 0.0027 0.0031
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0043 0.0332 0.4074
Plasmodium falciparum acyl-CoA synthetase 0.0043 0.0332 0.4074
Brugia malayi ORL1-like opioid receptor 0.0013 0.0027 0.0242
Onchocerca volvulus 0.0013 0.0027 0.0154
Entamoeba histolytica acyl-CoA synthetase, putative 0.0057 0.0482 0.3962
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0017 0.0147
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0417 0.049
Echinococcus multilocularis neuropeptide s receptor 0.0013 0.0027 0.0026
Brugia malayi follicle stimulating hormone receptor 0.0013 0.0027 0.0242
Echinococcus multilocularis serotonin receptor 0.0013 0.0027 0.0026
Echinococcus multilocularis pyruvate kinase 0.0064 0.0547 0.0546
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0017 0.0018
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0013 0.0027 0.0026
Brugia malayi hypothetical protein 0.0013 0.0027 0.0242
Echinococcus multilocularis neuropeptide receptor 0.0013 0.0027 0.0026
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0013 0.0027 0.0026
Onchocerca volvulus 0.0017 0.0064 0.0674
Onchocerca volvulus Pyruvate kinase homolog 0.0081 0.0722 1
Echinococcus multilocularis g protein coupled receptor 0.0013 0.0027 0.0026
Brugia malayi G protein-coupled receptor 0.0013 0.0027 0.0242
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0017 0.0147
Onchocerca volvulus 0.0057 0.0482 0.6591
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Echinococcus multilocularis tar DNA binding protein 0.0076 0.068 0.0679
Leishmania major pyruvate kinase 0.0081 0.0722 1
Echinococcus multilocularis g protein coupled receptor 0.0013 0.0027 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0064 0.0555
Leishmania major pyruvate kinase 0.0081 0.0722 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0057 0.0482 0.6344
Entamoeba histolytica pyruvate kinase, putative 0.0056 0.0471 0.3857
Echinococcus multilocularis pyruvate kinase 0.0081 0.0722 0.0721
Mycobacterium ulcerans acyl-CoA synthetase 0.0057 0.0482 0.6344
Schistosoma mansoni patched 1 0.0051 0.0417 0.0473
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.068 0.5997
Echinococcus multilocularis g-protein coupled receptor 0.0013 0.0027 0.0026
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Schistosoma mansoni hypothetical protein 0.0082 0.074 0.0854
Loa Loa (eye worm) oxidoreductase 0.0017 0.0064 0.0555
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0038 0.0284 0.0283
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0038 0.0284 0.2505
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0017 0.0147
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0017 0.0134
Entamoeba histolytica hypothetical protein 0.0043 0.0339 0.2609
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0013 0.0027 0.0242
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0013 0.0027 0.0013
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0134
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Onchocerca volvulus Pyruvate kinase homolog 0.0081 0.0722 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0027 0.0013
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Brugia malayi Dopamine receptor protein 2 0.0013 0.0027 0.0242
Schistosoma mansoni tar DNA-binding protein 0.0076 0.068 0.0783
Echinococcus granulosus tachykinin peptides receptor 99D 0.0013 0.0027 0.0031
Leishmania major 4-coumarate:coa ligase-like protein 0.0057 0.0482 0.6344
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0027 0.0013
Schistosoma mansoni histamine h1 receptor 0.0013 0.0027 0.0013
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.8494 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0017 0.0018
Brugia malayi AMP-binding enzyme family protein 0.0057 0.0482 0.425
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0057 0.0482 0.6344
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.8494 0.8494
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0017 0.0064 0.0555
Echinococcus granulosus neuropeptide FF receptor 2 0.0013 0.0027 0.0031
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0017 0.0147
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0017 0.0064 0.0566
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Brugia malayi CXXC zinc finger family protein 0.0035 0.0249 0.2194
Schistosoma mansoni hypothetical protein 0.0038 0.0284 0.0315
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0134
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0027 0.0013
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0013 0.0027 0.0026
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Brugia malayi G-protein coupled receptor 0.0013 0.0027 0.0242
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0017 0.0134
Echinococcus granulosus hypothetical protein 0.0013 0.0027 0.0031
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0038 0.0284 0.0333
Echinococcus granulosus pyruvate kinase 0.0041 0.0318 0.0372
Echinococcus multilocularis dro:myosuppressin receptor 0.0013 0.0027 0.0026
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0017 0.0147
Plasmodium vivax pyruvate kinase 2, putative 0.0041 0.0318 0.3849
Echinococcus granulosus alpha 1A adrenergic receptor 0.0013 0.0027 0.0031
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0027 0.0013
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0134
Loa Loa (eye worm) TAR-binding protein 0.0076 0.068 0.5997
Plasmodium vivax acyl-CoA synthetase, putative 0.0043 0.0332 0.4074
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0013 0.0027 0.0013
Echinococcus multilocularis GPCR, family 2 0.0038 0.0284 0.0283
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0134
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.1118 0.9863
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0013 0.0027 0.0026
Schistosoma mansoni hypothetical protein 0.0038 0.0284 0.0315
Onchocerca volvulus 0.0013 0.0027 0.0154
Entamoeba histolytica hypothetical protein 0.0043 0.0339 0.2609
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0017 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0017 0.0134
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0417 0.5366
Onchocerca volvulus 0.0013 0.0027 0.0154
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0017 0.0015
Brugia malayi neuropeptide F receptor 0.0013 0.0027 0.0242
Trypanosoma brucei pyruvate kinase 1, putative 0.0081 0.0722 1
Loa Loa (eye worm) RNA binding protein 0.0076 0.068 0.5997
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Schistosoma mansoni amine GPCR 0.0013 0.0027 0.0013
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0013 0.0027 0.0026
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0057 0.0482 0.6344
Brugia malayi AMP-binding enzyme family protein 0.0017 0.0064 0.0566
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0057 0.0482 0.6344
Echinococcus multilocularis neuropeptide receptor 0.0013 0.0027 0.0026
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.012 0.1134 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0013 0.0027 0.0031
Plasmodium vivax pyruvate kinase, putative 0.0081 0.0722 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Toxoplasma gondii pyruvate kinase PyK1 0.0081 0.0722 0.1486
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0017 0.0147
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Brugia malayi AMP-binding enzyme family protein 0.0057 0.0482 0.425
Loa Loa (eye worm) hypothetical protein 0.0082 0.074 0.6526
Brugia malayi AMP-binding enzyme family protein 0.0057 0.0482 0.425
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.1118 0.1117
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0024 0.0142 0.1255
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0013 0.0027 0.0026
Trichomonas vaginalis pyruvate kinase, putative 0.0081 0.0722 1
Brugia malayi pyruvate kinase, muscle isozyme 0.0017 0.0066 0.0581
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0027 0.0026
Onchocerca volvulus 0.0013 0.0027 0.0154
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0027 0.0031
Loa Loa (eye worm) hypothetical protein 0.0057 0.0482 0.4243
Schistosoma mansoni alpha-1 adrenergic receptor 0.0013 0.0027 0.0013
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0017 0.0015
Echinococcus granulosus pyruvate kinase 0.0041 0.0318 0.0372
Loa Loa (eye worm) G-protein coupled receptor 0.0013 0.0027 0.023
Echinococcus granulosus G protein coupled receptor 139 0.0013 0.0027 0.0031
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0013 0.0027 0.0242
Schistosoma mansoni hypothetical protein 0.0049 0.0398 0.045
Onchocerca volvulus 0.0013 0.0027 0.0154
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0013 0.0027 0.0026
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0013 0.0027 0.0013
Schistosoma mansoni hypothetical protein 0.0049 0.0398 0.045
Schistosoma mansoni neuropeptide F-like receptor 0.0013 0.0027 0.0013
Onchocerca volvulus 0.0017 0.0064 0.0674
Onchocerca volvulus 0.0013 0.0027 0.0154
Onchocerca volvulus 0.0013 0.0027 0.0154
Loa Loa (eye worm) hypothetical protein 0.0062 0.0536 0.4721
Onchocerca volvulus Pyruvate kinase homolog 0.0081 0.0722 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0013 0.0027 0.0031
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0013 0.0027 0.0013
Onchocerca volvulus 0.0035 0.0249 0.3288
Entamoeba histolytica acyl-CoA synthetase, putative 0.0057 0.0482 0.3962
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0013 0.0027 0.0026
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0057 0.0482 0.6344
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0013 0.0027 0.0031
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0017 0.0064 0.0555
Brugia malayi G-protein coupled receptor 0.0013 0.0027 0.0242
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0013 0.0027 0.0154
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Echinococcus multilocularis expressed conserved protein 0.0112 0.1044 0.1042
Loa Loa (eye worm) neuropeptide F receptor 0.0013 0.0027 0.023
Schistosoma mansoni tar DNA-binding protein 0.0076 0.068 0.0783
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0017 0.0015
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.004 0.0308 0.393
Onchocerca volvulus 0.0013 0.0027 0.0154
Echinococcus multilocularis neuropeptide Y receptor 0.0013 0.0027 0.0026
Schistosoma mansoni neuropeptide f receptor 76f 0.0013 0.0027 0.0013
Echinococcus granulosus somatostatin receptor 0.0013 0.0027 0.0031
Schistosoma mansoni hypothetical protein 0.0013 0.0027 0.0013
Echinococcus granulosus allatostatin A receptor 0.0013 0.0027 0.0031
Echinococcus multilocularis protein patched 0.0051 0.0417 0.0416
Mycobacterium ulcerans acyl-CoA synthetase 0.0057 0.0482 0.6344
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0013 0.0027 0.0242
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0017 0.0147
Onchocerca volvulus 0.0013 0.0027 0.0154
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1645 0.1644
Brugia malayi GnHR receptor homolog 0.0013 0.0027 0.0242
Brugia malayi RNA binding protein 0.0076 0.068 0.6002
Schistosoma mansoni biogenic amine receptor 0.0013 0.0027 0.0013
Echinococcus granulosus neuropeptide s receptor 0.0013 0.0027 0.0031
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0013 0.0027 0.0013
Brugia malayi RE15519p 0.0013 0.0027 0.0242
Loa Loa (eye worm) hypothetical protein 0.0056 0.0471 0.4145
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Loa Loa (eye worm) melatonin receptor type 1A 0.0013 0.0027 0.023
Echinococcus granulosus pyruvate kinase 0.0081 0.0722 0.0849
Brugia malayi Latrophilin receptor protein 2 0.0038 0.0284 0.2505
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Brugia malayi pyruvate kinase 0.0017 0.0066 0.0581
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.1137 0.1322
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0038 0.0284 0.0333
Echinococcus multilocularis pyruvate kinase 0.0041 0.0318 0.0316
Echinococcus granulosus tar DNA binding protein 0.0076 0.068 0.0799
Loa Loa (eye worm) pyruvate kinase 0.0081 0.0722 0.6368
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0027 0.0013
Schistosoma mansoni tar DNA-binding protein 0.0076 0.068 0.0783
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0013 0.0027 0.0026
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.004 0.0308 0.393
Echinococcus granulosus g-protein coupled receptor 0.0013 0.0027 0.0031
Echinococcus multilocularis sex peptide receptor 0.0013 0.0027 0.0026
Loa Loa (eye worm) hypothetical protein 0.0043 0.0332 0.2923
Onchocerca volvulus 0.0013 0.0027 0.0154
Echinococcus multilocularis somatostatin receptor 0.0013 0.0027 0.0026
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0017 0.0064 0.0063
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0017 0.0064 0.0354
Echinococcus granulosus sex peptide receptor 0.0013 0.0027 0.0031
Schistosoma mansoni amine GPCR 0.0013 0.0027 0.0013
Onchocerca volvulus 0.0013 0.0027 0.0154
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0017 0.0147
Brugia malayi AMP-binding enzyme family protein 0.0017 0.0064 0.0566
Brugia malayi Calcitonin receptor-like protein seb-1 0.012 0.1134 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.068 0.0783
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Schistosoma mansoni biogenic amine (5HT) receptor 0.0013 0.0027 0.0013
Echinococcus multilocularis neuropeptide receptor A26 0.0013 0.0027 0.0026
Schistosoma mansoni hypothetical protein 0.0013 0.0027 0.0013
Echinococcus multilocularis cpg binding protein 0.0037 0.0269 0.0268
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0013 0.0027 0.023
Brugia malayi CHE-14 protein 0.0051 0.0417 0.3682
Echinococcus multilocularis pyruvate kinase 0.0041 0.0318 0.0316
Loa Loa (eye worm) pigment dispersing factor receptor c 0.012 0.1134 1
Onchocerca volvulus 0.0013 0.0027 0.0154
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0017 0.0147
Schistosoma mansoni acetyl-CoA synthetase 0.0017 0.0064 0.0056
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0017 0.0064 0.0354
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0134
Brugia malayi putative neuropeptide receptor NPR1 0.0013 0.0027 0.0242
Schistosoma mansoni cpg binding protein 0.0037 0.0269 0.0298
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0017 0.0015
Schistosoma mansoni neuropeptide receptor 0.0013 0.0027 0.0013
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0027 0.0013
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0013 0.0027 0.0026
Trichomonas vaginalis pyruvate kinase, putative 0.0081 0.0722 1
Echinococcus granulosus expressed conserved protein 0.0112 0.1044 0.1227
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0017 0.0064 0.0354
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0013 0.0027 0.0013
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0013 0.0027 0.0013
Loa Loa (eye worm) hypothetical protein 0.0043 0.0332 0.2923
Brugia malayi sulfakinin receptor protein 0.0013 0.0027 0.0242
Echinococcus granulosus neuropeptide receptor 0.0013 0.0027 0.0031
Echinococcus granulosus dro:myosuppressin receptor 0.0013 0.0027 0.0031
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.068 0.6002
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0013 0.0027 0.023
Onchocerca volvulus Neuropeptide F receptor homolog 0.0013 0.0027 0.0154
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0017 0.0064 0.0354
Echinococcus multilocularis protein dispatched 1 0.0058 0.0492 0.049
Brugia malayi Pyruvate kinase, M2 isozyme 0.0081 0.0722 0.6372
Brugia malayi steroid hormone receptor 0.0012 0.0017 0.0147
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0027 0.0026
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0057 0.0482 0.6474
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0027 0.0031
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0027 0.0013
Onchocerca volvulus 0.0013 0.0027 0.0154
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0027 0.0031
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Loa Loa (eye worm) TYRA-2 protein 0.0013 0.0027 0.023
Brugia malayi Melatonin receptor type 1A 0.0013 0.0027 0.0242
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0013 0.0027 0.0026
Loa Loa (eye worm) pyruvate kinase 0.0081 0.0722 0.6368
Echinococcus granulosus neuropeptides capa receptor 0.0013 0.0027 0.0031
Brugia malayi hypothetical protein 0.0043 0.0339 0.2992
Echinococcus multilocularis pyruvate kinase 0.0081 0.0722 0.0721
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0017 0.0018
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0134
Brugia malayi hypothetical protein 0.0013 0.0027 0.0242
Loa Loa (eye worm) neuropeptide F receptor 0.0013 0.0027 0.023
Brugia malayi hypothetical protein 0.0013 0.0027 0.0242
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0017 0.0147
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0013 0.0027 0.0013
Brugia malayi hypothetical protein 0.0013 0.0027 0.0242
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0027 0.0031
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0017 0.0018
Echinococcus granulosus tm gpcr rhodopsin 0.0013 0.0027 0.0031
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0017 0.0018
Brugia malayi neuropeptide F receptor 0.0013 0.0027 0.0242
Loa Loa (eye worm) pyruvate kinase-PB 0.0056 0.0471 0.4145
Schistosoma mansoni cpg binding protein 0.0037 0.0269 0.0298
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0339 0.038
Echinococcus granulosus tm gpcr rhodopsin 0.0013 0.0027 0.0031
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0017 0.0147
Schistosoma mansoni biogenic amine (5HT) receptor 0.0013 0.0027 0.0013
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0043 0.0332 0.4283
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0013 0.0027 0.0013
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0038 0.0284 0.0283
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0057 0.0482 0.6344
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0134
Brugia malayi TAR-binding protein 0.0076 0.068 0.6002
Loa Loa (eye worm) pyruvate kinase 0.0017 0.0066 0.0569
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0013 0.0027 0.0031
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0064 0.0354
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0017 0.0018
Schistosoma mansoni pyruvate kinase 0.0081 0.0722 0.0833
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0017 0.0134
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0027 0.0013
Loa Loa (eye worm) hypothetical protein 0.0057 0.0482 0.4243
Echinococcus multilocularis g protein coupled receptor 0.0013 0.0027 0.0026
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0249 0.2184
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0017 0.0147
Schistosoma mansoni amine GPCR 0.0013 0.0027 0.0013
Brugia malayi hypothetical protein 0.0013 0.0027 0.0242
Trypanosoma cruzi pyruvate kinase 2, putative 0.0081 0.0722 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0027 0.0026
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0017 0.0064 0.0566
Schistosoma mansoni hypothetical protein 0.0038 0.0284 0.0315
Echinococcus granulosus g protein coupled receptor 0.0013 0.0027 0.0031
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0027 0.0026
Mycobacterium ulcerans hypothetical protein 0.0057 0.0482 0.6344
Echinococcus granulosus biogenic amine 5HT receptor 0.0013 0.0027 0.0031
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0017 0.0147
Brugia malayi putative neuropeptide receptor 0.0013 0.0027 0.0242
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0027 0.0026
Schistosoma mansoni hypothetical protein 0.0049 0.0398 0.045
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0017 0.0134
Brugia malayi hypothetical protein 0.0013 0.0027 0.0242
Onchocerca volvulus 0.0013 0.0027 0.0154
Mycobacterium ulcerans pyruvate kinase 0.0081 0.0722 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.004 0.0308 0.393
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0064 0.0354
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0027 0.0031
Loa Loa (eye worm) G-protein coupled receptor 0.0013 0.0027 0.023
Entamoeba histolytica hypothetical protein 0.0043 0.0339 0.2609
Brugia malayi AKH receptor 0.0013 0.0027 0.0242
Loa Loa (eye worm) hypothetical protein 0.0119 0.1118 0.9862
Schistosoma mansoni neuropeptide receptor 0.0013 0.0027 0.0013
Echinococcus granulosus neuropeptide Y receptor 0.0013 0.0027 0.0031
Brugia malayi latrophilin 2 splice variant baaae 0.0082 0.074 0.6531
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0027 0.0031
Loa Loa (eye worm) hypothetical protein 0.0051 0.0417 0.3674
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0064 0.0354
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0339 0.0398
Echinococcus multilocularis neuropeptide Y receptor 0.0013 0.0027 0.0026
Echinococcus multilocularis fmrfamide receptor 0.0013 0.0027 0.0026
Plasmodium falciparum pyruvate kinase 0.0081 0.0722 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0057 0.0482 0.6344
Echinococcus granulosus pyruvate kinase 0.0081 0.0722 0.0849
Trypanosoma cruzi pyruvate kinase 2, putative 0.0081 0.0722 1
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1645 0.1935
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Schistosoma mansoni biogenic amine receptor 0.0013 0.0027 0.0013
Echinococcus granulosus microtubule associated protein 2 0.0833 0.8494 1
Echinococcus multilocularis neuropeptides capa receptor 0.0013 0.0027 0.0026
Echinococcus multilocularis pyruvate kinase 0.0041 0.0318 0.0316
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0013 0.0027 0.023
Echinococcus granulosus neuropeptide receptor 0.0013 0.0027 0.0031
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Echinococcus granulosus 7TM GPCR rhodopsin 0.0013 0.0027 0.0031
Brugia malayi Dopamine receptor protein 1 0.0013 0.0027 0.0242
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0027 0.0026
Schistosoma mansoni hypothetical protein 0.0038 0.0284 0.0315
Echinococcus multilocularis orexin receptor type 2 0.0013 0.0027 0.0026
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0027 0.0031
Echinococcus granulosus g protein coupled receptor 0.0013 0.0027 0.0031
Loa Loa (eye worm) pyruvate kinase 0.0081 0.0722 0.6368
Schistosoma mansoni biogenic amine receptor 0.0013 0.0027 0.0013
Brugia malayi Tachykinin-like peptides receptor 99D 0.0013 0.0027 0.0242
Schistosoma mansoni opsin-like receptor 0.0013 0.0027 0.0013
Giardia lamblia Pyruvate kinase 0.0081 0.0722 1
Schistosoma mansoni hypothetical protein 0.0043 0.0339 0.038
Loa Loa (eye worm) hypothetical protein 0.0081 0.0722 0.6368
Entamoeba histolytica hypothetical protein 0.0043 0.0339 0.2609
Echinococcus multilocularis neuropeptides capa receptor 0.0013 0.0027 0.0026
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0081 0.0722 1
Echinococcus multilocularis fmrfamide receptor 0.0013 0.0027 0.0026
Schistosoma mansoni hypothetical protein 0.0013 0.0027 0.0013
Loa Loa (eye worm) hypothetical protein 0.0057 0.0482 0.4243
Loa Loa (eye worm) hypothetical protein 0.012 0.1134 1
Echinococcus granulosus serotonin receptor 0.0013 0.0027 0.0031
Echinococcus granulosus tm gpcr rhodopsin 0.0013 0.0027 0.0031
Onchocerca volvulus 0.0013 0.0027 0.0154
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.065 0.0747
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Brugia malayi larval opioid receptor 0.0013 0.0027 0.0242
Schistosoma mansoni opsin-like receptor 0.0013 0.0027 0.0013
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0013 0.0027 0.0242
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0057 0.0482 0.6474
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Echinococcus granulosus GPCR family 2 0.0038 0.0284 0.0333
Schistosoma mansoni neuropeptide receptor 0.0013 0.0027 0.0013
Schistosoma mansoni neuropeptide F-like receptor 0.0013 0.0027 0.0013
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.004 0.0308 0.393
Schistosoma mansoni amine GPCR 0.0013 0.0027 0.0013
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0013 0.0027 0.0026
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0064 0.0354
Loa Loa (eye worm) hypothetical protein 0.0017 0.0064 0.0555
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0017 0.0018
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0013 0.0027 0.0031
Brugia malayi AMP-binding enzyme family protein 0.0017 0.0064 0.0566
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0013 0.0027 0.0242
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0017 0.0134
Loa Loa (eye worm) hypothetical protein 0.0043 0.0332 0.2923
Schistosoma mansoni cpg binding protein 0.0035 0.0249 0.0274
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0013 0.0027 0.0013
Onchocerca volvulus 0.0017 0.0064 0.0674
Loa Loa (eye worm) latrophilin receptor protein 2 0.0038 0.0284 0.2495
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Brugia malayi nuclear receptor NHR-88 0.0012 0.0017 0.0147
Echinococcus granulosus pyruvate kinase 0.0041 0.0318 0.0372
Onchocerca volvulus 0.0013 0.0027 0.0154
Leishmania major 4-coumarate:coa ligase-like protein 0.0057 0.0482 0.6344
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0339 0.0338
Brugia malayi G protein-coupled receptor F59B2.13 0.0013 0.0027 0.0242
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.1118 0.1315
Plasmodium falciparum pyruvate kinase 2 0.0041 0.0318 0.3849
Brugia malayi nuclear hormone receptor 0.0012 0.0017 0.0147
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0013 0.0027 0.0013
Brugia malayi AMP-binding enzyme family protein 0.0017 0.0064 0.0566
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0017 0.0147
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0027 0.0013
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0134
Echinococcus granulosus fmrfamide receptor 0.0013 0.0027 0.0031
Echinococcus granulosus neuropeptides capa receptor 0.0013 0.0027 0.0031
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0017 0.0064 0.0354
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0017 0.0147
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0013 0.0027 0.023
Brugia malayi ecdysteroid receptor 0.0012 0.0017 0.0147
Echinococcus granulosus biogenic amine 5HT receptor 0.0013 0.0027 0.0031
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0013 0.0027 0.023
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Chlamydia trachomatis pyruvate kinase 0.0081 0.0722 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0027 0.0026
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0027 0.0026
Mycobacterium leprae Probable pyruvate kinase PykA 0.0081 0.0722 1
Toxoplasma gondii pyruvate kinase PyKII 0.0041 0.0318 0.0572
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0013 0.0027 0.0013
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0417 0.049
Schistosoma mansoni growth hormone secretagogue receptor 0.0013 0.0027 0.0013
Echinococcus multilocularis neuropeptide FF receptor 2 0.0013 0.0027 0.0026
Onchocerca volvulus 0.0017 0.0064 0.0674
Entamoeba histolytica acyl-coA synthetase, putative 0.0057 0.0482 0.3962
Schistosoma mansoni hypothetical protein 0.0049 0.0398 0.045
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Echinococcus multilocularis allatostatin A receptor 0.0013 0.0027 0.0026
Echinococcus granulosus orexin receptor type 2 0.0013 0.0027 0.0031
Brugia malayi Serotonin receptor 0.0013 0.0027 0.0242
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0017 0.0015
Onchocerca volvulus 0.0013 0.0027 0.0154
Brugia malayi hypothetical protein 0.0013 0.0027 0.0242
Echinococcus granulosus 7tm_1 domain containing protein 0.0013 0.0027 0.0031
Echinococcus multilocularis G-protein coupled receptor, putative 0.0013 0.0027 0.0026
Echinococcus multilocularis G protein coupled receptor 139 0.0013 0.0027 0.0026
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0017 0.0064 0.0354
Schistosoma mansoni opsin-like receptor 0.0013 0.0027 0.0013
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0013 0.0027 0.0013
Brugia malayi Pyruvate kinase, muscle isozyme 0.0081 0.0722 0.6372
Echinococcus multilocularis serotonin receptor 0.0013 0.0027 0.0026
Schistosoma mansoni neuropeptide receptor 0.0013 0.0027 0.0013
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0017 0.0015
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0417 0.0416
Schistosoma mansoni adenoreceptor 0.0013 0.0027 0.0013
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0013 0.0027 0.0031
Loa Loa (eye worm) hypothetical protein 0.0038 0.0284 0.2495
Brugia malayi hypothetical protein 0.0013 0.0027 0.0242
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0013 0.0027 0.0031
Schistosoma mansoni hypothetical protein 0.0013 0.0027 0.0013
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.023
Schistosoma mansoni myosin xvIII 0.0013 0.0027 0.0013
Brugia malayi hypothetical protein 0.0013 0.0027 0.0242
Toxoplasma gondii 1,3-beta-glucan synthase component protein 0.0446 0.4495 1

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 3.81 uM PUBCHEM_BIOASSAY: Inhibitors of Epstein-Barr LMP1 inducible NF-kappaB luciferase reporter Measured in Cell-Based System Using Plate Reader - 2122-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504586] ChEMBL. No reference
AC50 (functional) = 9.762 uM PUBCHEM_BIOASSAY: Viability counterscreen of potential LMP-1 inhibitors in HEK293 cell background Measured in Cell-Based System Using Plate Reader - 2122-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504586] ChEMBL. No reference
AC50 (functional) = 13.873 uM PUBCHEM_BIOASSAY: Lymphoblastoid Cells (LCL) Cytotoxicity Secondary Assay Measured in Cell-Based System Using Plate Reader - 2122-03_Inhibitor_Dose_CherryPick_Activity_Set2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504586] ChEMBL. No reference
EC50 (binding) = 1.091 um PUBCHEM_BIOASSAY: Luminescence Biochemical Dose Response HTS to Identify Inhibitors of Luciferase. (Class of assay: confirmatory) [Related pubchem assays: 1663 (Primary HTS), 1678 (Summary of Project)] ChEMBL. No reference
EC50 (functional) = 7.951 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to BJeLR RAS-Dependent Fibroblast. (Class of assay: confirmatory) [Related pubchem assays: 1674 (Project Summary), 1554 (Primary HTS)] ChEMBL. No reference
EC50 (functional) = 10.773 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to BJ-TERT RAS-Independent Fibroblast. (Class of assay: confirmatory) [Related pubchem assays: 1674 (Project Summary), 1554 (Primary HTS)] ChEMBL. No reference
EC50 (functional) = 18.878 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to BJ-TERT-LT-ST RAS-Independent Fibroblast. (Class of assay: confirmatory) [Related pubchem assays: 1674 (Project Summary), 1554 (Primary HTS)] ChEMBL. No reference
Ki (binding) = 18.7 uM Inhibition baboon liver mitochondrial MAOB ChEMBL. 17416530
Potency (functional) 0.1346 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 0.231 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 0.2936 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 0.3661 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 0.3696 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 0.3981 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.5623 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.4581 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 4.4668 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase (LmPK). (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Leishmania Mexicana Pyruvate Kinase (LmPK). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: Counterscreen for Luciferase (Kinase-Glo TM) Inhibition. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (binding) = 10 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 37.933 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.