Detailed information for compound 427450

Basic information

Technical information
  • TDR Targets ID: 427450
  • Name: N-[4-(6,7-dimethoxy-3,4-dihydro-1H-isoquinoli n-2-yl)butyl]-2-(2-fluoroethoxy)-5-iodobenzam ide
  • MW: 556.409 | Formula: C24H30FIN2O4
  • H donors: 1 H acceptors: 1 LogP: 4.39 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: FCCOc1ccc(cc1C(=O)NCCCCN1CCc2c(C1)cc(c(c2)OC)OC)I
  • InChi: 1S/C24H30FIN2O4/c1-30-22-13-17-7-11-28(16-18(17)14-23(22)31-2)10-4-3-9-27-24(29)20-15-19(26)5-6-21(20)32-12-8-25/h5-6,13-15H,3-4,7-12,16H2,1-2H3,(H,27,29)
  • InChiKey: IRFSOVRQSWDTBI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)butyl]-2-(2-fluoroethoxy)-5-iodo-benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus sigma non-opioid intracellular receptor 1 Starlite/ChEMBL References
Cavia porcellus Sigma-1 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi ERG2 and Sigma1 receptor like protein Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania mexicana C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma brucei gambiense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131051 All targets in OG5_131051
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania major C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma congolense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma congolense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania infantum C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Candida albicans sterol C8-C7 isomerase Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma brucei C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Candida albicans sterol C8-C7 isomerase Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania donovani C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma cruzi C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania braziliensis C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0039 0.0225 0.0912
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0039 0.0225 0.0912
Brugia malayi hypothetical protein 0.0036 0.0203 0.0316
Schistosoma mansoni hypothetical protein 0.0031 0.0172 0.0196
Schistosoma mansoni hypothetical protein 0.0031 0.0172 0.0196
Loa Loa (eye worm) hypothetical protein 0.0018 0.0076 0.0115
Treponema pallidum fructose-bisphosphate aldolase 0.0293 0.2051 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0033 0.0058
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0136 0.0152
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0008 0.0003 0.0005
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0039 0.0225 0.0912
Loa Loa (eye worm) peptidase family M13 containing protein 0.0069 0.0442 0.0695
Mycobacterium tuberculosis Probable homoserine O-acetyltransferase MetA (homoserine O-trans-acetylase) (homoserine transacetylase) (HTA) 0.0039 0.0225 0.0184
Onchocerca volvulus 0.0024 0.0119 0.0994
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0042 0.0057
Brugia malayi CXXC zinc finger family protein 0.0029 0.0156 0.0241
Schistosoma mansoni lamin 0.0027 0.0143 0.0162
Loa Loa (eye worm) hypothetical protein 0.0093 0.0616 0.0971
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0255 0.372
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0069 0.0028
Brugia malayi hydrolase, alpha/beta fold family protein 0.0039 0.0225 0.0351
Loa Loa (eye worm) hypothetical protein 0.0071 0.0454 0.0713
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0203 0.0231
Mycobacterium ulcerans exported protease 0.0039 0.0225 0.0184
Echinococcus multilocularis abhydrolase domain containing protein 3 0.0039 0.0225 0.0397
Mycobacterium leprae Probable exported protease 0.0039 0.0225 0.1231
Loa Loa (eye worm) hypothetical protein 0.0024 0.0119 0.0184
Trypanosoma brucei hydrolase, alpha/beta fold family, putative 0.0039 0.0225 0.0292
Entamoeba histolytica alpha/beta hydrolase domain protein, putative 0.0039 0.0225 0.0546
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0293 0.2051 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0059 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0209 0.0833
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0006 0.0007
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.023 0.0937
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0008 0.0003 0.0005
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0069 0.0028
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0059 0.0309
Mycobacterium ulcerans hypothetical protein 0.0039 0.0225 0.0184
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0059 0.0028
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0143 0.0221
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.0559 0.0519
Echinococcus multilocularis smad 0.0008 0.0006 0.001
Brugia malayi HAD-superfamily hydrolase, subfamily IA, variant 1 containing protein 0.0036 0.0209 0.0325
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.117 0.5617
Brugia malayi Thioredoxin reductase 0.0037 0.0216 0.0337
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0119 0.0078
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0036 0.0209 0.0833
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0278 0.0376
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0041 0.0047
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0012 0.0014
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0059 0.0944
Entamoeba histolytica HAD hydrolase, family IA, variant 3 0.0036 0.0209 0.0464
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0036 0.0209 0.0833
Mycobacterium tuberculosis Probable oxidoreductase 0.0039 0.0225 0.0184
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0423 0.0609
Loa Loa (eye worm) haloacid dehalogenase-like hydrolase 0.0036 0.0209 0.0325
Plasmodium vivax glutathione reductase, putative 0.0037 0.0216 0.8169
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0278 0.0492
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0013 0.0022
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0423 0.0482
Mycobacterium ulcerans bromoperoxidase BpoC 0.0039 0.0225 0.0184
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0255 0.1064
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0059 0.0831
Mycobacterium ulcerans hydrolase 0.0039 0.0225 0.0184
Mycobacterium ulcerans hypothetical protein 0.0039 0.0225 0.0184
Echinococcus multilocularis abhydrolase domain containing protein 11 0.0039 0.0225 0.0397
Mycobacterium ulcerans lipase/esterase 0.0039 0.0225 0.0184
Echinococcus granulosus geminin 0.017 0.1167 0.1579
Schistosoma mansoni Smad4 0.0008 0.0006 0.0007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0278 0.0317
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0047 0.0285 0.0325
Mycobacterium tuberculosis Probable haloalkane dehalogenase 0.0039 0.0225 0.0184
Echinococcus multilocularis lamin 0.0027 0.0143 0.0252
Onchocerca volvulus 0.0027 0.0143 0.1195
Loa Loa (eye worm) Smad1 0.0008 0.0006 0.0004
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0039 0.0225 0.1231
Loa Loa (eye worm) hypothetical protein 0.0069 0.0442 0.0695
Mycobacterium ulcerans 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD 0.0039 0.0225 0.0184
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0172 0.0305
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0069 0.0028
Brugia malayi intermediate filament protein 0.0027 0.0143 0.0221
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0076 0.0035
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0076 0.1625
Trypanosoma cruzi glycosyl hydrolase, putative 0.0036 0.0209 0.0267
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0076 0.1845
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0013 0.0015
Trypanosoma cruzi hydrolase-like protein, putative 0.0039 0.0225 0.0292
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0042 0.0075
Mycobacterium leprae Probable hydrolase 0.0036 0.0209 0.1046
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0119 0.0184
Echinococcus granulosus neuropeptide s receptor 0.0465 0.3282 0.4439
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0095 0.0627 0.0588
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0036 0.0209 0.0833
Mycobacterium ulcerans haloalkane dehalogenase 0.0039 0.0225 0.0184
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.1236 0.5945
Loa Loa (eye worm) HAD-superfamily hydrolase 0.0036 0.0209 0.0325
Schistosoma mansoni hypothetical protein 0.017 0.1167 0.1328
Loa Loa (eye worm) glutathione reductase 0.0037 0.0216 0.0337
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0788 0.1243
Mycobacterium ulcerans epoxide hydrolase EphE 0.0039 0.0225 0.0184
Echinococcus granulosus Solute carrier family 22 5 0.1039 0.7394 1
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.181 0.8803
Loa Loa (eye worm) HAD-superfamily hydrolase 0.0036 0.0209 0.0325
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0006 0.0004
Brugia malayi isocitrate dehydrogenase 0.0015 0.0059 0.0089
Schistosoma mansoni hypothetical protein 0.0012 0.0033 0.0037
Schistosoma mansoni steroid hormone receptor ad4bp 0.0008 0.0003 0.0004
Brugia malayi hypothetical protein 0.0017 0.007 0.0106
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0008 0.0003 0.0005
Mycobacterium ulcerans hypothetical protein 0.0024 0.0119 0.0078
Loa Loa (eye worm) hypothetical protein 0.0069 0.0442 0.0695
Loa Loa (eye worm) hypothetical protein 0.0071 0.0454 0.0713
Loa Loa (eye worm) hypothetical protein 0.0027 0.0143 0.0221
Brugia malayi HAD-superfamily hydrolase, subfamily IA, variant 3 containing protein 0.0036 0.0209 0.0325
Mycobacterium ulcerans epoxide hydrolase EphB 0.0039 0.0225 0.0184
Entamoeba histolytica haloacid dehalogenase-like hydrolase domain-containing protein 0.0036 0.0209 0.0464
Echinococcus granulosus Smad4 0.0008 0.0006 0.0008
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0119 0.0078
Loa Loa (eye worm) hypothetical protein 0.0046 0.0279 0.0437
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0059 0.0028
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0656 0.1033
Schistosoma mansoni hydrolase 0.0039 0.0225 0.0255
Echinococcus granulosus histone acetyltransferase KAT2B 0.0141 0.0962 0.1301
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0143 0.0975 1
Echinococcus granulosus abhydrolase domain containing protein 0.0039 0.0225 0.0304
Loa Loa (eye worm) hypothetical protein 0.0031 0.0172 0.0268
Echinococcus granulosus ephrin type A receptor 4 A 0.0063 0.0396 0.0536
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0432 0.0679
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0255 0.0345
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0036 0.0209 0.0833
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0059 0.0028
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0136 0.0152
Mycobacterium ulcerans lipase/esterase 0.0039 0.0225 0.0184
Brugia malayi MH2 domain containing protein 0.0008 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0071 0.0454 0.0713
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0006 0.001
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0036 0.0209 0.0325
Brugia malayi MH1 domain containing protein 0.0008 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0889 0.6319 1
Entamoeba histolytica hypothetical protein 0.0036 0.0203 0.0434
Loa Loa (eye worm) HAD-superfamily hydrolase 0.0036 0.0209 0.0325
Entamoeba histolytica alpha/beta hydrolase fold protein, putative 0.0039 0.0225 0.0546
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0008 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0093 0.0616 0.0971
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0041 0.006
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0036 0.0209 0.0833
Mycobacterium tuberculosis Probable carboxylesterase CaeA 0.0039 0.0225 0.0184
Mycobacterium tuberculosis Conserved protein 0.0039 0.0225 0.0184
Brugia malayi glutathione reductase 0.0037 0.0216 0.0337
Mycobacterium tuberculosis Probable oxidoreductase 0.0095 0.0627 0.0588
Entamoeba histolytica HAD hydrolase, family IA, variant 3 0.0036 0.0209 0.0464
Mycobacterium ulcerans haloalkane dehalogenase 0.0039 0.0225 0.0184
Plasmodium falciparum glutathione reductase 0.0037 0.0216 0.9277
Leishmania major hydrolase-like protein,esterase-like protein 0.0039 0.0225 0.0292
Schistosoma mansoni hypothetical protein 0.0024 0.0123 0.014
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0008 0.0003 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0225 0.0292
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.117 0.5617
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0209 0.0833
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0023 0.0111 0.0126
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0143 0.0975 0.0938
Leishmania major trypanothione reductase 0.0037 0.0216 0.0278
Leishmania major hydrolase, alpha/beta fold family, putative 0.0039 0.0225 0.0292
Schistosoma mansoni intermediate filament proteins 0.0027 0.0143 0.0162
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0076 0.0035
Echinococcus multilocularis abhydrolase domain containing protein 16A 0.0039 0.0225 0.0397
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0216 0.0278
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.2051 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0095 0.0627 0.5926
Loa Loa (eye worm) zinc metallopeptidase 4 0.0023 0.0111 0.0171
Schistosoma mansoni neprilysin 0.0024 0.0123 0.014
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0255 0.372
Loa Loa (eye worm) hypothetical protein 0.0093 0.0616 0.0971
Mycobacterium leprae POSSIBLE EPOXIDE HYDROLASE EPHE (EPOXIDE HYDRATASE) (ARENE-OXIDE HYDRATASE) 0.0039 0.0225 0.1231
Loa Loa (eye worm) hypothetical protein 0.0013 0.0039 0.0056
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0039 0.0225 0.0184
Entamoeba histolytica HAD hydrolase, family IA, variant 3 0.0036 0.0209 0.0464
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.022 0.0297
Onchocerca volvulus Lipase homolog 0.0039 0.0225 0.1897
Loa Loa (eye worm) hydrolase 0.0039 0.0225 0.0351
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0036 0.0209 0.0833
Echinococcus granulosus GPCR family 2 0.0031 0.0172 0.0233
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.117 0.5617
Giardia lamblia Hydrolase, putative 0.0036 0.0209 0.0833
Echinococcus multilocularis Smad4 0.0008 0.0006 0.001
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0036 0.0209 0.0833
Brugia malayi Alpha/beta hydrolase 0.0039 0.0225 0.0351
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.2051 1
Toxoplasma gondii homoserine O-acetyltransferase, putative 0.0039 0.0225 0.3188
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0423 0.0665
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0008 0.0003 0.0005
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0255 1
Mycobacterium ulcerans epoxide hydrolase EphF 0.0039 0.0225 0.0184
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0076 0.2076
Schistosoma mansoni smad1 5 8 and 0.0008 0.0006 0.0007
Brugia malayi peptidase family M13 containing protein 0.0023 0.0111 0.0171
Echinococcus granulosus abhydrolase domain containing protein 11 0.0039 0.0225 0.0304
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0036 0.0209 0.0833
Brugia malayi Smad1 0.0008 0.0006 0.0004
Onchocerca volvulus 0.0027 0.0143 0.1195
Schistosoma mansoni choline dehydrogenase 0.0036 0.0209 0.0237
Entamoeba histolytica HAD hydrolase, family IA, variant 3 0.0036 0.0209 0.0464
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0278 0.0376
Echinococcus granulosus neuropeptide receptor A26 0.0465 0.3282 0.4439
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0119 0.0078
Brugia malayi UPF0017 protein CG3488 0.0039 0.0225 0.0351
Entamoeba histolytica haloacid dehalogenase-like hydrolase domain-containing protein 0.0036 0.0209 0.0464
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0036 0.0209 0.0833
Echinococcus multilocularis cpg binding protein 0.0031 0.0167 0.0296
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0119 0.0078
Schistosoma mansoni thyroid hormone receptor 0.0008 0.0003 0.0004
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0039 0.0225 0.0912
Loa Loa (eye worm) peptidase family M13 containing protein 0.0069 0.0442 0.0695
Schistosoma mansoni hypothetical protein 0.0024 0.0123 0.014
Wolbachia endosymbiont of Brugia malayi phosphatase 0.0036 0.0209 1
Brugia malayi hypothetical protein 0.0026 0.0136 0.0211
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0278 0.0317
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0039 0.0225 0.0912
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0036 0.0209 0.0833
Schistosoma mansoni smad1 5 8 and 0.0008 0.0006 0.0007
Schistosoma mansoni hypothetical protein 0.0024 0.0123 0.014
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0225 0.0292
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.181 0.8803
Schistosoma mansoni lamin 0.0027 0.0143 0.0162
Entamoeba histolytica haloacid dehalogenase-like hydrolase domain-containing protein 0.0036 0.0209 0.0464
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0036 0.0209 0.0833
Schistosoma mansoni cpg binding protein 0.0029 0.0156 0.0177
Onchocerca volvulus 0.0029 0.0156 0.1307
Schistosoma mansoni hypothetical protein 0.0024 0.0123 0.014
Loa Loa (eye worm) hypothetical protein 0.0069 0.0442 0.0695
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.023 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0119 0.0124
Plasmodium falciparum haloacid dehalogenase-like hydrolase, putative 0.0036 0.0209 0.8889
Loa Loa (eye worm) hypothetical protein 0.0039 0.0225 0.0351
Mycobacterium ulcerans hydrolase 0.0036 0.0209 0.0168
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0119 0.0078
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.026 0.181 0.2861
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0225 0.8569
Trypanosoma cruzi hydrolase-like protein, putative 0.0039 0.0225 0.0292
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0059 0.0104
Mycobacterium tuberculosis Probable exported protease 0.0039 0.0225 0.0184
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0036 0.0209 0.0325
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0008 0.0003 0.0005
Giardia lamblia ENC6 protein 0.0039 0.0225 0.0912
Onchocerca volvulus 0.0062 0.0392 0.3329
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0216 0.8169
Echinococcus granulosus lamin 0.0027 0.0143 0.0193
Schistosoma mansoni hypothetical protein 0.0036 0.0203 0.0231
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0136 0.5055
Toxoplasma gondii thioredoxin reductase 0.0037 0.0216 0.3039
Loa Loa (eye worm) hypothetical protein 0.0018 0.0076 0.0115
Echinococcus granulosus abhydrolase domain containing protein 3 0.0039 0.0225 0.0304
Brugia malayi Hypothetical 54.7 kDa protein F37A4.1 in chromosome III 0.0039 0.0225 0.0351
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.023 0.0572
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0209 0.0267
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0119 0.0078
Plasmodium falciparum alpha/beta hydrolase, putative 0.0039 0.0225 0.9731
Echinococcus granulosus lamin dm0 0.0027 0.0143 0.0193
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0052 0.0078
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0119 0.0078
Loa Loa (eye worm) hypothetical protein 0.0024 0.0119 0.0184
Mycobacterium ulcerans short chain dehydrogenase 0.0039 0.0225 0.0184
Entamoeba histolytica hypothetical protein 0.0036 0.0203 0.0434
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.001 0.0017 0.0021
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0172 0.0268
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0036 0.0209 0.0833
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0156 0.0241
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0143 0.0221
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0209 0.0833
Mycobacterium ulcerans hydrolase 0.0036 0.0209 0.0168
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.0039 0.0225 0.0292
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.0559 0.0519
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0036 0.0209 0.0833
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0059 0.0104
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0008 0.0003 0.0004
Onchocerca volvulus Lipase homolog 0.0039 0.0225 0.1897
Loa Loa (eye worm) acetyltransferase 0.0146 0.0991 0.1564
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0036 0.0209 0.0325
Loa Loa (eye worm) hypothetical protein 0.0018 0.0076 0.0115
Mycobacterium leprae probable zinc metalloprotease 0.0093 0.0616 0.5805
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0047 0.0285 0.0325
Echinococcus multilocularis musashi 0.0027 0.0143 0.0252
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0224 0.1557 0.177
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.0991 0.1564
Chlamydia trachomatis phosphoglycolate phosphatase 0.0036 0.0209 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0059 0.008
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0278 0.0492
Plasmodium vivax alpha/beta hydrolase, putative 0.0039 0.0225 0.8569
Loa Loa (eye worm) hypothetical protein 0.0062 0.0392 0.0615
Loa Loa (eye worm) hypothetical protein 0.0067 0.0432 0.0679
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.1236 0.5945
Schistosoma mansoni neprilysin-2 (M13 family) 0.0047 0.0285 0.0325
Echinococcus multilocularis haloacid dehalogenase hydrolase 0.0036 0.0209 0.0369
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0041 0.0073
Entamoeba histolytica hypothetical protein 0.0039 0.0225 0.0546
Mycobacterium ulcerans peroxidase BpoB 0.0039 0.0225 0.0184
Brugia malayi alpha/beta hydrolase 0.0039 0.0225 0.0351
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.117 0.5617
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0209 0.0833
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0172 0.0233
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0278 0.0436
Onchocerca volvulus Glucosylceramidase homolog 0.0171 0.117 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0423 0.0609
Schistosoma mansoni 2-deoxyglucose-6-phosphate phosphatase 0.0036 0.0209 0.0237
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0023 0.0111 0.0126
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.0559 0.0519
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0796 0.5653 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0293 0.2051 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0454 0.0713
Echinococcus multilocularis endothelin converting enzyme 1 0.0093 0.0616 0.109
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0039 0.0225 0.0912
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.117 0.5617
Brugia malayi Peptidase family M13 containing protein 0.0093 0.0616 0.0971
Trichomonas vaginalis hydrolase, putative 0.0039 0.0225 0.0912
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0036 0.0209 0.0833
Mycobacterium ulcerans hypothetical protein 0.0039 0.0225 0.0184
Mycobacterium ulcerans lignin peroxidase LipJ 0.0039 0.0225 0.0184
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0656 0.1033
Echinococcus multilocularis lysosomal acid lipase:cholesteryl ester 0.0039 0.0225 0.0397
Leishmania major serine peptidase, putative,serine peptidase, Clan SC, Family S9D 0.0039 0.0225 0.0292
Loa Loa (eye worm) hypothetical protein 0.0018 0.0076 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0209 0.0833
Plasmodium falciparum epoxide hydrolase 1 0.0039 0.0225 0.9731
Echinococcus granulosus smad 0.0008 0.0006 0.0008
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0423 0.0665
Mycobacterium ulcerans non-heme haloperoxidase Hpx 0.0039 0.0225 0.0184
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0889 0.6319 1
Schistosoma mansoni nuclear hormone receptor 0.0008 0.0003 0.0004
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0216 0.0337
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0036 0.0209 0.0833
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.181 0.8803
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0013 0.0017
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0278 0.0436
Schistosoma mansoni endothelin-converting enzyme-related 0.0023 0.0111 0.0126
Mycobacterium ulcerans oxidoreductase 0.0039 0.0225 0.0184
Brugia malayi MH1 domain containing protein 0.0008 0.0006 0.0004
Brugia malayi hydrolase, alpha/beta fold family protein 0.0039 0.0225 0.0351
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0036 0.0209 0.0833
Mycobacterium tuberculosis Possible haloalkane dehalogenase 0.0039 0.0225 0.0184
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0059 0.0028
Mycobacterium leprae POSSIBLE SECRETED PROTEASE 0.0039 0.0225 0.1231
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0423 0.0749
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0036 0.0209 0.0833
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.2051 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.0059 0.0018
Toxoplasma gondii alpha/beta hydrolase, putative 0.0039 0.0225 0.3188
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0172 0.0305
Leishmania major hydrolase-like protein 0.0039 0.0225 0.0292
Schistosoma mansoni cpg binding protein 0.0031 0.0167 0.019
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0203 0.0359
Mycobacterium ulcerans epoxide hydrolase EphA 0.1403 1 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0008 0.0003 0.0004
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0143 0.0221
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0136 0.1656
Trypanosoma brucei hydrolase, alpha/beta fold family, putative 0.0039 0.0225 0.0292
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0059 0.0104
Mycobacterium ulcerans zinc metalloprotease 0.0093 0.0616 0.0577
Echinococcus multilocularis geminin 0.017 0.1167 0.2065
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0209 0.0833
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0006 0.001
Schistosoma mansoni hypothetical protein 0.0031 0.0172 0.0196
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0172 0.0233
Echinococcus granulosus intermediate filament protein 0.0027 0.0143 0.0193
Loa Loa (eye worm) hypothetical protein 0.0099 0.0656 0.1033
Schistosoma mansoni coup transcription factor 0.0008 0.0003 0.0004
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0047 0.0285 0.0325
Loa Loa (eye worm) hypothetical protein 0.0071 0.0454 0.0713
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0423 0.0573
Loa Loa (eye worm) hypothetical protein 0.0071 0.0454 0.0713
Schistosoma mansoni RAR-like nuclear receptor 0.0008 0.0003 0.0004
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.117 0.5617
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0036 0.0209 0.0325
Schistosoma mansoni hypothetical protein 0.0024 0.0123 0.014
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.181 0.8803
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0059 0.0309
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0052 0.0078
Mycobacterium ulcerans exported protease 0.0039 0.0225 0.0184
Brugia malayi ephrin receptor 1 precursor 0.003 0.0162 0.0252
Echinococcus multilocularis GPCR, family 2 0.0031 0.0172 0.0305
Echinococcus granulosus cpg binding protein 0.0031 0.0167 0.0226
Loa Loa (eye worm) haloacid dehalogenase-like hydrolase 0.0036 0.0209 0.0325
Mycobacterium ulcerans hypothetical protein 0.0036 0.0209 0.0168
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0203 0.0274
Entamoeba histolytica hypothetical protein 0.0036 0.0209 0.0464
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0008 0.0003 0.0005
Echinococcus multilocularis ecdysone induced protein 78C 0.0008 0.0003 0.0005
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0006 0.0008
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0008 0.0003 0.0004
Schistosoma mansoni smad 0.0008 0.0006 0.0007
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0036 0.0209 0.0833
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0008 0.0003 0.0004
Mycobacterium ulcerans hydrolase 0.0039 0.0225 0.0184
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0008 0.0003 0.0004
Loa Loa (eye worm) abhydrolase domain-containing protein 2 0.0039 0.0225 0.0351
Schistosoma mansoni hypothetical protein 0.0067 0.0432 0.0491
Echinococcus multilocularis thyroid hormone receptor alpha 0.0008 0.0003 0.0005
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0047 0.0285 0.0325
Entamoeba histolytica hypothetical protein 0.0036 0.0203 0.0434
Plasmodium vivax haloacid dehalogenase-like hydrolase, putative 0.0036 0.0209 0.7827
Loa Loa (eye worm) hypothetical protein 0.0036 0.0209 0.0325
Echinococcus granulosus haloacid dehalogenase hydrolase 0.0036 0.0209 0.0282
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0059 0.0104
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0216 0.0175
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.2051 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0423 0.0609
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0223 0.0302
Schistosoma mansoni hypothetical protein 0.017 0.1167 0.1328
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0023 0.0111 0.0126
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0008 0.0003 0.0004
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.2051 1
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0136 0.0152
Mycobacterium leprae Probable homoserine o-acetyltransferase MetA 0.0039 0.0225 0.1231
Loa Loa (eye worm) hypothetical protein 0.0455 0.3205 0.5069
Plasmodium falciparum acid cluster protein 33 homologue, putative 0.0039 0.0225 0.9731
Giardia lamblia Phosphoglycolate phosphatase 0.0036 0.0209 0.0833
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0225 0.8569
Mycobacterium tuberculosis Conserved hypothetical protein 0.0036 0.0209 0.0168
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.0026 0.0136 0.0211
Echinococcus multilocularis haloacid dehalogenase hydrolase 0.0036 0.0209 0.0369
Echinococcus multilocularis abhydrolase domain containing 3 0.0039 0.0225 0.0397
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1235 0.8792 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.0991 0.1127
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0036 0.0209 0.0833
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0059 0.0089
Schistosoma mansoni hypothetical protein 0.0024 0.0123 0.014
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0093 0.0616 0.0701
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0209 0.0168
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0059 0.0028
Mycobacterium ulcerans homoserine O-acetyltransferase 0.0039 0.0225 0.0184
Mycobacterium ulcerans hypothetical protein 0.0039 0.0225 0.0184
Trypanosoma cruzi hydrolase-like protein 0.0039 0.0225 0.0292
Loa Loa (eye worm) TK/EPH protein kinase 0.0079 0.0518 0.0815
Loa Loa (eye worm) hypothetical protein 0.0018 0.0076 0.0115
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0136 0.5055
Leishmania major hypothetical protein, conserved 0.0039 0.0225 0.0292
Loa Loa (eye worm) hypothetical protein 0.0031 0.0174 0.0271
Loa Loa (eye worm) hypothetical protein 0.0039 0.0225 0.0351
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.181 0.8803
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0223 0.0395
Schistosoma mansoni hypothetical protein 0.0031 0.0172 0.0196
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.0991 0.1753
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0119 0.0184
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0059 0.0089
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.181 0.8803
Echinococcus granulosus endothelin converting enzyme 1 0.0093 0.0616 0.0833
Onchocerca volvulus 0.0036 0.0209 0.1762
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0036 0.0209 0.0833
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0033 0.0044
Echinococcus multilocularis lamin dm0 0.0027 0.0143 0.0252
Echinococcus granulosus ecdysone induced protein 78C 0.0008 0.0003 0.0004
Echinococcus multilocularis lysosomal acid lipase:cholesteryl ester 0.0039 0.0225 0.0397
Echinococcus multilocularis FTZ F1 alpha 0.0008 0.0003 0.0005
Mycobacterium ulcerans proline iminopeptidase PIP 0.0039 0.0225 0.0184
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0008 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0013 0.0039 0.0056
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.2051 1
Entamoeba histolytica hypothetical protein 0.0036 0.0203 0.0434
Entamoeba histolytica HAD hydrolase, family IA, variant 3 0.0036 0.0209 0.0464
Loa Loa (eye worm) HAD-superfamily hydrolase 0.0036 0.0209 0.0325
Loa Loa (eye worm) hypothetical protein 0.0024 0.0119 0.0184
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0008 0.0003 0.0004
Giardia lamblia Hydrolase, haloacid dehalogenase-like family 0.0036 0.0209 0.0833
Loa Loa (eye worm) hypothetical protein 0.0013 0.0042 0.0062
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0788 0.1243
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0172 0.0268
Loa Loa (eye worm) hypothetical protein 0.0069 0.0442 0.0695
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0036 0.0209 0.0833
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0293 0.2051 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0423 0.0609
Onchocerca volvulus 0.0036 0.0209 0.1762
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0095 0.0627 0.0588
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0023 0.0111 0.0126
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.2051 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0039 0.0225 0.0912
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0041 0.0056
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0119 0.0078
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.026 0.181 0.2861
Leishmania major hypothetical protein, conserved 0.0026 0.0136 0.0152
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0036 0.0209 0.0833
Treponema pallidum phosphoglycolate phosphatase 0.0036 0.0209 0.0833
Echinococcus multilocularis ephrin type A receptor 4 A 0.0063 0.0396 0.0701
Brugia malayi MH2 domain containing protein 0.0117 0.0788 0.1243
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0119 0.0078
Onchocerca volvulus 0.0046 0.0279 0.2367
Leishmania major C-8 sterol isomerase-like protein 0.0889 0.6319 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0059 0.0104
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0024 0.0123 0.014
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0889 0.6319 1
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0225 0.8569
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0008 0.0003 0.0004
Mycobacterium ulcerans hypothetical protein 0.0036 0.0209 0.0168
Schistosoma mansoni family S33 non-peptidase homologue (S33 family) 0.0039 0.0225 0.0255
Mycobacterium tuberculosis Possible epoxide hydrolase EphE (epoxide hydratase) (arene-oxide hydratase) 0.0039 0.0225 0.0184
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0172 0.0268
Schistosoma mansoni retinoic acid receptor RXR 0.0008 0.0003 0.0004
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0008 0.0003 0.0004
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0136 0.4452
Entamoeba histolytica HAD hydrolase, family IA, variant 3 0.0036 0.0209 0.0464
Echinococcus granulosus FTZ F1 alpha 0.0008 0.0003 0.0004
Mycobacterium tuberculosis Possible epoxide hydrolase EphF (epoxide hydratase) (arene-oxide hydratase) 0.0039 0.0225 0.0184
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0023 0.0111 0.0126
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0143 0.0975 0.0938
Leishmania major hypothetical protein, conserved 0.0039 0.0225 0.0292
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0656 0.1033
Brugia malayi MH2 domain containing protein 0.0008 0.0006 0.0004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0008 0.0003 0.0004
Echinococcus multilocularis neuropeptide s receptor 0.0465 0.3282 0.5806
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0255 0.1064
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.001 0.0017 0.0021
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0119 0.0184
Schistosoma mansoni cpg binding protein 0.0031 0.0167 0.019
Loa Loa (eye worm) hypothetical protein 0.0027 0.0139 0.0215
Echinococcus multilocularis abhydrolase domain containing protein 0.0039 0.0225 0.0397
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0006 0.0004
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0069 0.0028
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.022 0.0388
Trypanosoma brucei C-8 sterol isomerase, putative 0.0889 0.6319 1
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0093 0.0616 0.0971
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0119 0.0124
Mycobacterium tuberculosis Protein tyrosine kinase transcriptional regulatory protein PtkA 0.0036 0.0209 0.0168
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0278 0.0317
Schistosoma mansoni ephrin receptor 0.0063 0.0396 0.0451
Mycobacterium tuberculosis Possible phosphatase 0.0036 0.0209 0.0168
Schistosoma mansoni smad1 5 8 and 0.0008 0.0006 0.0007
Plasmodium falciparum thioredoxin reductase 0.0037 0.0216 0.9277
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.0423 0.1575
Mycobacterium tuberculosis Possible haloalkane dehalogenase DhaA (1-chlorohexane halidohydrolase) 0.0039 0.0225 0.0184
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0085 0.0559 0.5132
Onchocerca volvulus Epoxide hydrolase 1 homolog 0.0039 0.0225 0.1897
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0209 0.0833
Leishmania major hydrolase, alpha/beta fold family-like protein 0.0039 0.0225 0.0292
Leishmania major hydrolase-like protein,esterase-like protein 0.0039 0.0225 0.0292
Schistosoma mansoni thyroid hormone receptor 0.0008 0.0003 0.0004
Mycobacterium ulcerans acyl-CoA synthetase 0.0039 0.0231 0.0191
Loa Loa (eye worm) ab-hydrolase associated lipase region family protein 0.0039 0.0225 0.0351
Echinococcus granulosus haloacid dehalogenase hydrolase 0.0036 0.0209 0.0282
Echinococcus granulosus lysosomal acid lipase:cholesteryl ester 0.0039 0.0225 0.0304
Entamoeba histolytica hypothetical protein 0.0036 0.0209 0.0464
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0366 0.5654
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.117 0.5617
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.0559 0.0519
Mycobacterium tuberculosis Possible peroxidase BpoB (non-haem peroxidase) 0.0039 0.0225 0.0184
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0119 0.0124
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.0559 0.0519
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0225 0.0292
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0209 0.0833
Mycobacterium leprae Probable exported protease 0.0039 0.0225 0.1231
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0388 0.0441
Toxoplasma gondii peptidase family M13 protein 0.0093 0.0616 1
Giardia lamblia Phosphoglycolate phosphatase 0.0036 0.0209 0.0833
Trypanosoma brucei trypanothione reductase 0.0037 0.0216 0.0278
Treponema pallidum phosphoglycolate phosphatase 0.0036 0.0209 0.0833
Echinococcus multilocularis neuropeptide receptor A26 0.0465 0.3282 0.5806
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.2051 1
Mycobacterium tuberculosis Probable reductase 0.0085 0.0559 0.0519
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0036 0.0209 0.0833
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0093 0.0616 0.0577

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 1.06 nM Displacement of [3H]DTG from sigma 2 receptor in rat liver membrane after 120 mins ChEMBL. 17579383
Ki (binding) = 1300 nM Displacement of [3H](+)pentazocine from sigma 1 receptor in guinea pig brain membrane after 90 mins ChEMBL. 17579383
Ki (binding) = 1300 nM Displacement of [3H](+)pentazocine from sigma 1 receptor in guinea pig brain membrane after 90 mins ChEMBL. 17579383
Ki (binding) = 1300 nM Displacement of 5-bromo-N-(4-(3,4-dihydro-6,7-dimethoxyisoquinolin-2(1H)-yl)butyl)-2,3-dimethoxybenzamide from sigma-1 receptor in mouse EMT6 cell membranes after 60 mins by Scatchard plot analysis ChEMBL. 24821398
Ratio Ki (binding) = 1230 Selectivity for rat liver sigma 2 receptor over guinea pig brain sigma 1 receptor ChEMBL. 17579383

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.