Detailed information for compound 430244

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 578.401 | Formula: C25H25Cl2N5O7
  • H donors: 2 H acceptors: 7 LogP: 4.08 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(N[C@@H]1CCCCNC1=O)/C=C/[C@H](N(C(=O)c1cc(cc(c1)[N+](=O)[O-])[N+](=O)[O-])C)Cc1ccc(c(c1)Cl)Cl
  • InChi: 1S/C25H25Cl2N5O7/c1-30(25(35)16-12-18(31(36)37)14-19(13-16)32(38)39)17(10-15-5-7-20(26)21(27)11-15)6-8-23(33)29-22-4-2-3-9-28-24(22)34/h5-8,11-14,17,22H,2-4,9-10H2,1H3,(H,28,34)(H,29,33)/b8-6+/t17-,22+/m0/s1
  • InChiKey: JHUKJMFMSFZCSW-KISUKSLOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0253 0.0253
Loa Loa (eye worm) hypothetical protein 0.002 0.0136 0.0242
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.001 0.0016 0.0029
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0135 0.0135
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0002 0.0003
Brugia malayi Calcitonin receptor-like protein seb-1 0.015 0.1787 0.3177
Loa Loa (eye worm) hypothetical protein 0.0046 0.0471 0.0838
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0136 0.2429
Loa Loa (eye worm) hypothetical protein 0.002 0.0136 0.0242
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0135 0.0239
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0486 0.0486
Brugia malayi hypothetical protein 0.0073 0.0808 0.1437
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0056 0.0099
Toxoplasma gondii propionate-CoA ligase 0.0014 0.0056 0.0997
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0253 0.0451
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0009 0.0001 0.0026
Onchocerca volvulus 0.0029 0.0253 0.0447
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0003
Brugia malayi nuclear hormone receptor 0.002 0.0135 0.0239
Plasmodium vivax hypothetical protein, conserved 0.0009 0.0001 0.0046
Leishmania major importin beta-1 subunit, putative 0.0023 0.0173 0.3086
Loa Loa (eye worm) hypothetical protein 0.002 0.0135 0.0239
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0003
Onchocerca volvulus 0.0048 0.0497 0.0881
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0118 0.21
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0135 0.0239
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0135 0.0239
Loa Loa (eye worm) glycogen phosphorylase 0.0452 0.5625 1
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0056 0.0103
Brugia malayi CHE-14 protein 0.0041 0.0407 0.0724
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0135 0.0239
Trichomonas vaginalis ran, putative 0.0021 0.0146 0.0162
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0118 0.0111
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0118 0.0268
Loa Loa (eye worm) hypothetical protein 0.002 0.0135 0.0239
Brugia malayi topoisomerase 0.002 0.0136 0.0242
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.1185 0.2106
Echinococcus granulosus survival motor neuron protein 1 0.0231 0.2818 0.501
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0118 0.3651
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0135 0.0239
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0056 0.0103
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0245 0.0436
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.0561 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0407 0.0724
Entamoeba histolytica hypothetical protein 0.002 0.0136 0.0144
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.001 0.0016 0.0029
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0299 0.1143
Echinococcus multilocularis GPCR, family 2 0.0047 0.0486 0.0486
Giardia lamblia Replication factor C, subunit 1 0.002 0.0136 0.0034
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0486 0.0863
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0561 1
Schistosoma mansoni glycogen phosphorylase 0.0452 0.5625 1
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0135 0.0239
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0323 0.1155
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0135 0.0239
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0056 0.0099
Echinococcus granulosus thyroid hormone receptor alpha 0.0009 0.0002 0.0003
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0056 0.0056
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0.0136 0.0144
Echinococcus granulosus nuclear receptor nhr 48 0.0009 0.0002 0.0003
Trichomonas vaginalis replication factor C large subunit, putative 0.002 0.0136 0.0144
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.0561 1
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.0321 0.0571
Loa Loa (eye worm) hypothetical protein 0.0013 0.0045 0.008
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.1068 0.1899
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0135 0.0135
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0016 0.0029
Schistosoma mansoni ran 0.0021 0.0146 0.026
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0195 0.2366 1
Brugia malayi nuclear receptor RXR 0.0009 0.0002 0.0003
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.034 0.0604
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0056 0.0103
Schistosoma mansoni hypothetical protein 0.004 0.0388 0.069
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.0561 0.0561
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0146 0.026
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0056 0.0099
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0245 0.0436
Loa Loa (eye worm) hypothetical protein 0.0014 0.0056 0.0099
Brugia malayi hypothetical protein 0.0231 0.2818 0.501
Loa Loa (eye worm) hypothetical protein 0.0028 0.0245 0.0436
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0046 0.0471 1
Chlamydia trachomatis glycogen phosphorylase 0.0452 0.5625 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0056 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0136 0.0144
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.03 0.3701 0.658
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0321 0.0571
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0486 0.0863
Schistosoma mansoni hypothetical protein 0.0165 0.1986 0.3531
Loa Loa (eye worm) hypothetical protein 0.002 0.0136 0.0242
Entamoeba histolytica glycogen phosphorylase, putative 0.0452 0.5625 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0009 0.0002 0.0003
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0135 0.0135
Onchocerca volvulus 0.0014 0.0056 0.0096
Entamoeba histolytica acyl-coA synthetase, putative 0.0046 0.0471 0.0746
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0146 0.2608
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0015 0.0028
Echinococcus granulosus voltage gated potassium channel 0.001 0.0015 0.0028
Brugia malayi ecdysteroid receptor 0.002 0.0135 0.0239
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0002 0.0003
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0173 0.0211
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0135 0.0239
Toxoplasma gondii ATPase, AAA family protein 0.002 0.0136 0.2429
Loa Loa (eye worm) hypothetical protein 0.0029 0.0253 0.0451
Loa Loa (eye worm) hypothetical protein 0.0102 0.1185 0.2106
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0245 0.0436
Schistosoma mansoni hypothetical protein 0.0047 0.0482 0.0857
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0056 0.0099
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0118 0.0118
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.1104 0.1882
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0135 0.0135
Entamoeba histolytica hypothetical protein 0.0073 0.0808 0.1351
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.2464 0.4381
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0014 0.0056 0.1733
Trypanosoma brucei protein kinase, putative 0.0053 0.0561 1
Brugia malayi intermediate filament protein 0.0026 0.0218 0.0387
Schistosoma mansoni ap endonuclease 0.0018 0.0118 0.021
Echinococcus granulosus FTZ F1 alpha 0.002 0.0135 0.0239
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0195 0.2366 1
Onchocerca volvulus 0.0231 0.2821 0.5014
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0471 0.0838
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.001 0.0016 0.0016
Echinococcus granulosus importin subunit beta 1 0.0028 0.0241 0.0428
Toxoplasma gondii exonuclease III APE 0.0018 0.0118 0.21
Echinococcus granulosus jumonji domain containing protein 0.004 0.0387 0.0688
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0471 0.84
Plasmodium vivax SET domain protein, putative 0.0029 0.0253 0.7852
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.034 0.0604
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0003
Entamoeba histolytica hypothetical protein 0.0073 0.0808 0.1351
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.0561 0.0998
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0241 0.0241
Onchocerca volvulus 0.0014 0.0056 0.0096
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0299 0.1143
Entamoeba histolytica glycogen phosphorylase, putative 0.0452 0.5625 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0241 0.429
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0135 0.0239
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0471 0.0838
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0486 0.0863
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0056 0.0997
Loa Loa (eye worm) oxidoreductase 0.0014 0.0056 0.0099
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.0029
Schistosoma mansoni DNA ligase IV 0.002 0.0136 0.0242
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.1104 0.1963
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.0561 0.0998
Schistosoma mansoni thyroid hormone receptor 0.002 0.0135 0.0239
Schistosoma mansoni importin beta-1 0.0028 0.0241 0.0428
Schistosoma mansoni hypothetical protein 0.0009 0.0001 0.0003
Loa Loa (eye worm) DR-78 0.0009 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0035 0.0323 0.0574
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0407 0.0724
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.1104 0.1104
Schistosoma mansoni hypothetical protein 0.03 0.3701 0.658
Schistosoma mansoni nuclear receptor nhr-48 0.0009 0.0002 0.0003
Onchocerca volvulus 0.0026 0.0218 0.0384
Schistosoma mansoni lamin 0.0026 0.0218 0.0387
Brugia malayi nuclear hormone receptor family member nhr-6 0.0009 0.0002 0.0003
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.002 0.0136 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0218 0.0387
Echinococcus multilocularis glycogen phosphorylase 0.0452 0.5625 0.5625
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0009 0.0002 0.0002
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0096 0.1104 0.1963
Loa Loa (eye worm) hypothetical protein 0.002 0.0136 0.0242
Loa Loa (eye worm) hypothetical protein 0.0046 0.0471 0.0838
Loa Loa (eye worm) hypothetical protein 0.0049 0.0504 0.0895
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0135 0.0239
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0241 0.429
Brugia malayi nuclear receptor NHR-88 0.002 0.0135 0.0239
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.1068 0.1068
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0046 0.0471 0.1799
Schistosoma mansoni glycogen phosphorylase 0.0452 0.5625 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0003
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0387 0.0387
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0003
Echinococcus multilocularis protein dispatched 1 0.0047 0.0481 0.0481
Brugia malayi Bromodomain containing protein 0.0028 0.0245 0.0436
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0002 0.0003
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0323 0.034
Brugia malayi jmjC domain containing protein 0.0093 0.1068 0.1899
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0146 0.0146
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0561 0.0908
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.1365 0.2426
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0056 0.0997
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.0561 0.0998
Onchocerca volvulus 0.0017 0.0104 0.0181
Echinococcus multilocularis Glycosyl transferase, family 35 0.0452 0.5625 0.5625
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0056 0.0103
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0009 0.0001 0.0026
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.002 0.0136 0.0348
Entamoeba histolytica glycogen phosphorylase, putative 0.0195 0.2366 0.4148
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.0561 1
Onchocerca volvulus Alhambra homolog 0.0028 0.0245 0.0433
Brugia malayi MAP kinase sur-1 0.0053 0.0561 0.0998
Brugia malayi carbohydrate phosphorylase 0.0452 0.5625 1
Brugia malayi MH2 domain containing protein 0.0117 0.1365 0.2426
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0003
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0808 0.1437
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0471 0.84
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0003
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0056 0.0997
Schistosoma mansoni ap endonuclease 0.0018 0.0118 0.021
Schistosoma mansoni intermediate filament proteins 0.0026 0.0218 0.0387
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0135 0.0135
Brugia malayi steroid hormone receptor 0.002 0.0135 0.0239
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0808 0.1437
Echinococcus multilocularis peregrin 0.0028 0.0245 0.0245
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0253 0.4515
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0471 0.1799
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0056 0.0103
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.001 0.0016 0.0029
Echinococcus granulosus peregrin 0.0028 0.0245 0.0436
Loa Loa (eye worm) hypothetical protein 0.002 0.0136 0.0242
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0135 0.0239
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.1104 0.1963
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0056 0.0103
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0002 0.0003
Echinococcus multilocularis nuclear receptor nhr 48 0.0009 0.0002 0.0002
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0561 0.0998
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0118 0.0368
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.0561 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.063 0.1121
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0321 0.0571
Brugia malayi hypothetical protein 0.001 0.0016 0.0029
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0016 0.0029
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0136 0.2429
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.034 0.034
Onchocerca volvulus 0.002 0.0136 0.0239
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0135 0.0236
Plasmodium vivax acetyl-CoA synthetase, putative 0.0014 0.0056 0.1733
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.0471 0.0746
Mycobacterium ulcerans hypothetical protein 0.0046 0.0471 0.1799
Brugia malayi PHD-finger family protein 0.0009 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0014 0.0056 0.0099
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0323 0.1246
Schistosoma mansoni chromosome transmission fidelity factor 0.002 0.0136 0.0242
Brugia malayi conserved hypotetical protein 0.0009 0.0002 0.0003
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0135 0.0239
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0015 0.0028
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0009 0.0002 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0135 0.0239
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0321 0.0321
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0003
Echinococcus multilocularis geminin 0.0165 0.1986 0.1986
Onchocerca volvulus 0.0047 0.0482 0.0854
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0253 0.0451
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0118 0.21
Entamoeba histolytica hypothetical protein 0.0073 0.0808 0.1351
Echinococcus multilocularis voltage gated potassium channel 0.001 0.0015 0.0015
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0002 0.0003
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.1123 0.1997
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0135 0.0239
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0245 0.4365
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0056 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0136 0.0144
Schistosoma mansoni hypothetical protein 0.0047 0.0486 0.0863
Echinococcus multilocularis lamin dm0 0.0026 0.0218 0.0218
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.0561 0.0561
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0135 0.0239
Echinococcus granulosus intermediate filament protein 0.0026 0.0218 0.0387
Loa Loa (eye worm) hypothetical protein 0.0048 0.0497 0.0884
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0173 0.0211
Schistosoma mansoni nuclear receptor 0.0009 0.0002 0.0003
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.031 0.0456
Brugia malayi Pre-SET motif family protein 0.0203 0.2464 0.4381
Loa Loa (eye worm) hypothetical protein 0.002 0.0135 0.0239
Brugia malayi nuclear receptor RXR 0.001 0.0016 0.0029
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0253 0.0253
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0561 1
Schistosoma mansoni hypothetical protein 0.0102 0.1185 0.2106
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0002 0.0002
Echinococcus granulosus geminin 0.0165 0.1986 0.3531
Schistosoma mansoni hypothetical protein 0.0073 0.0808 0.1437
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.024 0.0426
Onchocerca volvulus 0.002 0.0135 0.0236
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.001 0.0015 0.0015
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.1628 0.2895
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.002 0.0135 0.0239
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0118 0.21
Entamoeba histolytica hypothetical protein 0.0023 0.0173 0.0211
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0486 0.0863
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0135 0.0239
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0045 0.0045
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0173 0.0211
Brugia malayi Pre-SET motif family protein 0.0029 0.0253 0.0451
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.0056 0.0997
Echinococcus multilocularis replication factor c subunit 1 0.002 0.0136 0.0136
Schistosoma mansoni ran 0.0021 0.0146 0.026
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0146 0.4536
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0056 0.0099
Entamoeba histolytica glycogen phosphorylase, putative 0.0195 0.2366 0.4148
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0009 0.0002 0.0002
Brugia malayi hypothetical protein 0.0009 0.0002 0.0003
Schistosoma mansoni topbp1 0.002 0.0136 0.0242
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0135 0.0239
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0056 0.0103
Echinococcus multilocularis protein patched 0.0041 0.0407 0.0407
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.002 0.0136 0.1935
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0063 0.0111
Brugia malayi nuclear hormone receptor 0.0009 0.0002 0.0003
Giardia lamblia PHD finger protein 15 0.0028 0.0245 0.0231
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0135 0.0239
Schistosoma mansoni topbp1 0.002 0.0136 0.0242
Echinococcus multilocularis snurportin 1 0.03 0.3701 0.3701
Echinococcus granulosus GPCR family 2 0.0047 0.0486 0.0863
Loa Loa (eye worm) pigment dispersing factor receptor c 0.015 0.1787 0.3177
Echinococcus multilocularis lamin 0.0026 0.0218 0.0218
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0046 0.0471 1
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0135 0.0239
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0056 0.0997
Onchocerca volvulus Glycogen phosphorylase homolog 0.0452 0.5625 1
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0561 0.0908
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0825 0.1466
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0135 0.0239
Echinococcus granulosus replication factor c subunit 1 0.002 0.0136 0.0242
Onchocerca volvulus 0.0014 0.0056 0.0096
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0135 0.0239
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0135 0.0239
Brugia malayi AF-10 protein 0.0009 0.0001 0.0003
Onchocerca volvulus 0.0046 0.0471 0.0835
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.002 0.0136 0.0144
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0253 0.0451
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0146 0.2608
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0056 0.0099
Loa Loa (eye worm) nuclear hormone receptor 0.0009 0.0002 0.0003
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0321 0.0571
Brugia malayi ecdysone receptor 0.0009 0.0002 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0135 0.0239
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0118 0.021
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0009 0.0002 0.0003
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0382 0.0679
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0136 0.0144
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0407 0.0724
Loa Loa (eye worm) hypothetical protein 0.0035 0.0323 0.0574
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0471 0.84
Loa Loa (eye worm) hypothetical protein 0.0028 0.0241 0.0428
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.0029
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0046 0.0471 0.1799
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.0029
Loa Loa (eye worm) hypothetical protein 0.002 0.0135 0.0239
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.0069
Schistosoma mansoni hypothetical protein 0.0047 0.0486 0.0863
Schistosoma mansoni patched 1 0.0041 0.0407 0.0724
Echinococcus granulosus potassium voltage gated channel subfamily H 0.001 0.0015 0.0028
Brugia malayi jmjC domain containing protein 0.0034 0.0321 0.0571
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0002 0.0003
Loa Loa (eye worm) nuclear receptor NHR-67 0.0009 0.0002 0.0003
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0009 0.0001 0.0046
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.1628 0.1628
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0136 0.0144
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.0561 0.0805
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0135 0.0239
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0382 0.0679
Brugia malayi hypothetical protein 0.002 0.0136 0.0242
Brugia malayi nuclear hormone receptor family member odr-7 0.0009 0.0002 0.0003
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0056 0.0997
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0135 0.0239
Schistosoma mansoni hypothetical protein 0.0047 0.0486 0.0863
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0015 0.0027
Schistosoma mansoni nuclear receptor 0.0009 0.0002 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0253 0.0451
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0135 0.0236
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0046 0.0471 0.1799
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0241 0.429
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0056 0.0997
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0135 0.0239
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0482 0.0857
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0118 0.21
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.0136 0.0144
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.0561 1
Trichomonas vaginalis set domain proteins, putative 0.0231 0.2821 0.4965
Loa Loa (eye worm) hypothetical protein 0.015 0.1787 0.3177
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0056 0.0103
Echinococcus granulosus glycogen phosphorylase 0.0452 0.5625 1
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0056 0.0103
Loa Loa (eye worm) hypothetical protein 0.0031 0.0279 0.0497
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0253 0.0451
Schistosoma mansoni hypothetical protein 0.004 0.0388 0.069
Echinococcus multilocularis tumor protein p63 0.033 0.4077 0.4077
Brugia malayi orphan nuclear receptor NR2E1 0.0009 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.002 0.0136 0.0242
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0135 0.0239
Loa Loa (eye worm) hypothetical protein 0.0035 0.0323 0.0574
Echinococcus granulosus lamin dm0 0.0026 0.0218 0.0387
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0009 0.0002 0.0003
Brugia malayi hypothetical protein 0.001 0.0016 0.0029
Entamoeba histolytica Ran family GTPase 0.0021 0.0146 0.0162
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0135 0.0239
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0118 0.0111
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0135 0.0239
Echinococcus multilocularis nibrin 0.002 0.0136 0.0136
Schistosoma mansoni lamin 0.0026 0.0218 0.0387
Schistosoma mansoni thyroid hormone receptor 0.002 0.0135 0.0239
Brugia malayi nuclear receptor NHR-67 0.0009 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0028
Treponema pallidum DNA ligase (lig) 0.002 0.0136 1
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.0136 0.0144
Plasmodium vivax replication factor C subunit 1, putative 0.002 0.0136 0.4224
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0063 0.0111
Loa Loa (eye worm) hypothetical protein 0.002 0.0135 0.0239
Brugia malayi nuclear receptor NHR-88 0.0009 0.0002 0.0003
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0015 0.0027
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0056 0.0099
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0561 0.0908
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0135 0.0239
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0045 0.008
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.002 0.0136 0.2429
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0056 0.0099
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.1365 0.2426
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0218 0.0387
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0118 0.021
Brugia malayi RNA, U transporter 1 0.008 0.09 0.16
Leishmania major GTP-binding protein, putative 0.0021 0.0146 0.2608
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0218 0.0387
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0135 0.0239
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0009 0.0001 0.0026
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.0561 1
Trypanosoma cruzi FHA domain containing protein, putative 0.002 0.0136 0.2429
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0.0136 0.2429
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0135 0.0135
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0135 0.0239
Giardia lamblia Glycogen phosphorylase 0.0452 0.5625 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0135 0.0239
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0056 0.0997
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0056 0.0997
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0407 0.0724
Loa Loa (eye worm) hypothetical protein 0.0231 0.2818 0.501
Echinococcus granulosus glycogen phosphorylase 0.0452 0.5625 1
Schistosoma mansoni hypothetical protein 0.0028 0.0245 0.0436
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0046 0.0471 0.1883
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0471 0.0838
Echinococcus multilocularis expressed conserved protein 0.009 0.103 0.103
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0135 0.0239
Schistosoma mansoni survival motor neuron protein 0.0047 0.0482 0.0857
Plasmodium falciparum replication factor C subunit 1, putative 0.002 0.0136 0.4224
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0.0136 0.2429
Brugia malayi Pax transcription activation domain interacting protein 0.002 0.0136 0.0242
Loa Loa (eye worm) hypothetical protein 0.0035 0.0323 0.0574
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0299 0.1143
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.031 0.0456
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0245 0.0245
Echinococcus multilocularis musashi 0.0026 0.0218 0.0218
Brugia malayi DKFZp564C0469 protein 0.002 0.0136 0.0242
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0136 0.0144
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0135 0.0239
Schistosoma mansoni hypothetical protein 0.004 0.0388 0.069
Echinococcus multilocularis glycogen phosphorylase 0.0452 0.5625 0.5625
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0118 0.021
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0003
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0407 0.0407
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0173 0.3086
Loa Loa (eye worm) hypothetical protein 0.002 0.0135 0.0239
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0486 0.0863
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.0029
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0016 0.0029
Echinococcus granulosus lamin 0.0026 0.0218 0.0387
Schistosoma mansoni nuclear hormone receptor 0.002 0.0135 0.0239
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0135 0.0135
Toxoplasma gondii PHD-finger domain-containing protein 0.0009 0.0001 0.0026
Entamoeba histolytica glycogenphosphorylase, putative 0.0195 0.2366 0.4148
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.0069
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0135 0.0236
Echinococcus granulosus snurportin 1 0.03 0.3701 0.658
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0003
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.034 0.0604
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0146 0.4536
Loa Loa (eye worm) hypothetical protein 0.0035 0.0323 0.0574
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0056 0.0103
Brugia malayi Importin beta-1 subunit 0.0028 0.0241 0.0428
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0003
Echinococcus granulosus nibrin 0.002 0.0136 0.0242
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0135 0.0239
Schistosoma mansoni hypothetical protein 0.0047 0.0486 0.0863
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0323 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0486 0.0486
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0135 0.0239
Loa Loa (eye worm) hypothetical protein 0.0026 0.0212 0.0376
Echinococcus granulosus tumor protein p63 0.033 0.4077 0.7248
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0471 0.1799
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.0471 0.0746
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0009 0.0002 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0135 0.0239
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0002 0.0002
Echinococcus multilocularis survival motor neuron protein 1 0.0231 0.2818 0.2818
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0245 0.7591
Echinococcus granulosus Glycosyl transferase family 35 0.0452 0.5625 1
Schistosoma mansoni coup transcription factor 0.002 0.0135 0.0239
Loa Loa (eye worm) hypothetical protein 0.002 0.0135 0.0239
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0003
Trichomonas vaginalis glycogen phosphorylase, putative 0.0452 0.5625 1
Brugia malayi PHD-finger family protein 0.0028 0.0245 0.0436
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0323 1
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0056 0.0099
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0218 0.0387
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0407 0.0631
Onchocerca volvulus 0.0026 0.0218 0.0384
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0003
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0118 0.0111
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0146 0.2608
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0046 0.0471 0.1883
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0135 0.0239
Schistosoma mansoni hypothetical protein 0.004 0.0388 0.069
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0561 0.0908
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0146 0.026
Plasmodium vivax importin-beta 2, putative 0.0028 0.0241 0.7461
Plasmodium falciparum importin beta, putative 0.0028 0.0241 0.7461
Loa Loa (eye worm) hypothetical protein 0.0046 0.0471 0.0838
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0471 0.1799
Plasmodium falciparum phd finger protein, putative 0.0028 0.0245 0.7591
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0056 0.0997
Brugia malayi hypothetical protein 0.002 0.0136 0.0242
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0146 0.2608
Loa Loa (eye worm) hypothetical protein 0.0047 0.0486 0.0863
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0056 0.0997
Brugia malayi tailless protein 0.0009 0.0002 0.0003
Trichomonas vaginalis glycogen phosphorylase, putative 0.0452 0.5625 1
Schistosoma mansoni glycogen phosphorylase 0.0195 0.2366 0.4206
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.0029
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0118 0.3651
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0046 0.0471 0.1799
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.001 0.0015 0.0028
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0.0136 0.0144
Schistosoma mansoni zinc finger protein 0.0009 0.0002 0.0003
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0808 0.0808
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.002 0.0136 0.0242
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0135 0.0239
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0245 0.4365
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0135 0.0239
Brugia malayi hypothetical protein 0.0009 0.0002 0.0003
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0146 0.026
Schistosoma mansoni hypothetical protein 0.0165 0.1986 0.3531
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0299 0.1143
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0146 0.0052
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.015 0.1787 0.3177
Loa Loa (eye worm) hypothetical protein 0.005 0.0525 0.0934
Entamoeba histolytica hypothetical protein 0.0073 0.0808 0.1351
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0497 0.0884
Echinococcus granulosus expressed conserved protein 0.009 0.103 0.1832

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 96.1 % Antagonist activity at NK2 receptor in guinea pig trachea as inhibition of [beta-Ala8]NKA(4-10)-induced bronchoconstriction relative to control ChEMBL. 17169559
Activity (functional) = 96.1 % Antagonist activity at NK1 receptor in guinea pig trachea as inhibition of ASM-SP-induced bronchoconstriction relative to control ChEMBL. 17169559
Activity (functional) = 96.1 % Antagonist activity at NK2 receptor in guinea pig trachea as inhibition of [beta-Ala8]NKA(4-10)-induced bronchoconstriction relative to control ChEMBL. 17169559
Activity (functional) = 96.1 % Antagonist activity at NK1 receptor in guinea pig trachea as inhibition of ASM-SP-induced bronchoconstriction relative to control ChEMBL. 17169559
pKb (functional) = 7.87 Antagonist activity at NK2 receptor in guinea pig trachea as inhibition of [beta-Ala8]NKA(4-10)-induced bronchoconstriction ChEMBL. 17169559
pKb (functional) = 8.4 Antagonist activity at NK1 receptor in guinea pig trachea as inhibition of ASM-SP-induced bronchoconstriction ChEMBL. 17169559

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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