Detailed information for compound 432751

Basic information

Technical information
  • TDR Targets ID: 432751
  • Name: 1H-indol-5-yl-(3,4,5-trimethoxyphenyl)methano ne
  • MW: 311.332 | Formula: C18H17NO4
  • H donors: 1 H acceptors: 1 LogP: 3.3 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(cc(c1OC)OC)C(=O)c1ccc2c(c1)cc[nH]2
  • InChi: 1S/C18H17NO4/c1-21-15-9-13(10-16(22-2)18(15)23-3)17(20)12-4-5-14-11(8-12)6-7-19-14/h4-10,19H,1-3H3
  • InChiKey: MPXGSKMOQWDKQF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tubulin, beta 2B class IIb Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta-1 tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-7 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-4 chain Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium hominis beta-catenin-like repeat protein Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi Tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Babesia bovis tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta-tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-2A chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma congolense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Theileria parva tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium parvum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin alpha chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-4 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium falciparum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin, beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium berghei tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma cruzi beta tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi beta-tubulin, identical Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium vivax tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium yoelii tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin gamma chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum tubulin gamma chain tubulin, beta 2B class IIb 445 aa 438 aa 32.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Zinc finger, PHD finger 0.0041 0.0087 0.0085
Loa Loa (eye worm) hypothetical protein 0.0133 0.0392 0.601
Leishmania major beta tubulin 0.003 0.0051 0.0129
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0087 0.1273
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0119 0.0347 0.5288
Loa Loa (eye worm) phosphatidylinositol 3 0.0041 0.0087 0.1329
Loa Loa (eye worm) phosphatidylinositol 3 0.0212 0.0652 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0078 0.5844
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0041 0.0087 0.1273
Echinococcus multilocularis expressed conserved protein 0.0103 0.0291 0.0289
Loa Loa (eye worm) hypothetical protein 0.004 0.0085 0.1302
Trichomonas vaginalis tubulin, putative 0.003 0.0051 0.0716
Echinococcus granulosus Tubulin beta 2C chain 0.003 0.0051 0.0049
Loa Loa (eye worm) hypothetical protein 0.0031 0.0055 0.085
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0041 0.0087 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0041 0.0087 0.1273
Trichomonas vaginalis tubulin beta chain, putative 0.003 0.0051 0.0716
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.0257 0.3905
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0041 0.0087 0.1273
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.004 0.0085 0.6421
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0054 0.013 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0041 0.0087 0.1273
Trypanosoma brucei beta tubulin 0.003 0.0051 0.0716
Leishmania major beta tubulin 0.003 0.0051 0.0129
Echinococcus multilocularis Tubulin beta 2C chain 0.003 0.0051 0.0049
Loa Loa (eye worm) hypothetical protein 0.0109 0.0313 0.4802
Schistosoma mansoni lamin 0.0031 0.0055 0.079
Echinococcus multilocularis Niemann Pick C1 protein 0.0156 0.0468 0.0466
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0041 0.0087 0.0238
Trypanosoma cruzi target of rapamycin kinase 3 0.0212 0.0652 0.1871
Leishmania major 4-coumarate:coa ligase-like protein 0.0054 0.013 0.0349
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0055 0.085
Echinococcus multilocularis tubulin, beta 4A class IVa 0.003 0.0051 0.0049
Loa Loa (eye worm) tubulin beta chain 0.003 0.0051 0.0776
Onchocerca volvulus 0.0031 0.0055 0.4074
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0041 0.0087 0.1273
Leishmania major beta tubulin 0.003 0.0051 0.0129
Onchocerca volvulus 0.0041 0.0087 0.6562
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0087 0.1273
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0212 0.0652 1
Giardia lamblia GTOR 0.0212 0.0652 1
Brugia malayi AMP-binding enzyme family protein 0.0054 0.013 0.194
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0041 0.0087 0.1273
Entamoeba histolytica acyl-CoA synthetase, putative 0.0054 0.013 0.194
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1839 0.6036 0.6035
Plasmodium falciparum acyl-CoA synthetase 0.004 0.0085 0.9786
Echinococcus multilocularis protein dispatched 1 0.0053 0.0129 0.0127
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0041 0.0087 0.1273
Echinococcus multilocularis Niemann Pick C1 protein 0.0109 0.0313 0.0311
Echinococcus granulosus tubulin subunit beta 0.003 0.0051 0.0049
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0041 0.0087 0.0599
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0119 0.0347 0.5288
Schistosoma mansoni tubulin subunit beta 0.003 0.0051 0.0716
Leishmania major beta tubulin 0.003 0.0051 0.0129
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0041 0.0087 0.0238
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0041 0.0087 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0212 0.0652 0.1871
Loa Loa (eye worm) phosphatidylinositol 3 0.0212 0.0652 1
Schistosoma mansoni hypothetical protein 0.0045 0.0101 0.15
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0212 0.0652 0.065
Loa Loa (eye worm) BEN-1 protein 0.003 0.0051 0.0776
Echinococcus multilocularis Tubulin beta 2C chain 0.003 0.0051 0.0049
Leishmania major beta tubulin 0.003 0.0051 0.0129
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0212 0.0652 0.1801
Loa Loa (eye worm) hypothetical protein 0.0054 0.013 0.1992
Onchocerca volvulus 0.0041 0.0087 0.6562
Leishmania major beta tubulin 0.003 0.0051 0.0129
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0119 0.0347 0.0345
Trichomonas vaginalis PIKK family atypical protein kinase 0.0212 0.0652 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.013 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0212 0.0652 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0041 0.0087 0.1273
Schistosoma mansoni tubulin subunit beta 0.003 0.0051 0.0716
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0041 0.0087 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0212 0.0652 0.1801
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0041 0.0087 0.1273
Echinococcus granulosus beta tubulin 0.003 0.0051 0.0049
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0041 0.0087 0.0085
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0041 0.0087 0.0085
Loa Loa (eye worm) hypothetical protein 0.0119 0.0347 0.5319
Loa Loa (eye worm) beta-tubulin 0.003 0.0051 0.0776
Schistosoma mansoni hypothetical protein 0.0041 0.0087 0.1273
Entamoeba histolytica tubulin family protein 0.003 0.0051 0.0716
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0212 0.0652 0.1871
Echinococcus multilocularis beta tubulin 0.003 0.0051 0.0049
Trypanosoma brucei beta tubulin 0.003 0.0051 0.0716
Loa Loa (eye worm) oxidoreductase 0.0016 0.0004 0.0065
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0041 0.0087 0.0599
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0041 0.0087 0.1273
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0195 0.2944
Brugia malayi CHE-14 protein 0.0047 0.0107 0.1586
Toxoplasma gondii beta-tubulin, putative 0.003 0.0051 0.0716
Echinococcus multilocularis tar DNA binding protein 0.0073 0.0195 0.0193
Trichomonas vaginalis PIKK family atypical protein kinase 0.0212 0.0652 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0078 0.5844
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0054 0.013 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0041 0.0087 0.0238
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0212 0.0652 1
Entamoeba histolytica hypothetical protein 0.0041 0.0087 0.1273
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0212 0.0652 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0041 0.0087 0.1273
Brugia malayi TAR-binding protein 0.0073 0.0195 0.2944
Loa Loa (eye worm) hypothetical protein 0.0092 0.0257 0.3945
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0041 0.0087 0.0229
Schistosoma mansoni fkbp-rapamycin associated protein 0.0119 0.0347 0.5288
Trichomonas vaginalis PIKK family atypical protein kinase 0.0212 0.0652 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0007 0.0113
Schistosoma mansoni patched 1 0.0047 0.0107 0.1586
Echinococcus granulosus Niemann Pick C1 protein 0.0109 0.0313 0.0311
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0029
Plasmodium falciparum tubulin beta chain 0.003 0.0051 0.5628
Echinococcus granulosus lamin 0.0031 0.0055 0.0054
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0079 0.0212 0.06
Echinococcus granulosus Tubulin beta 2C chain 0.003 0.0051 0.0049
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0087 0.6562
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0054 0.013 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0212 0.3209
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0041 0.0087 0.1273
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0041 0.0087 0.1273
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0041 0.0087 0.1273
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0041 0.0087 0.1273
Echinococcus multilocularis serine protein kinase ATM 0.0119 0.0347 0.0345
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0092 0.0257 0.0255
Trichomonas vaginalis PIKK family atypical protein kinase 0.0212 0.0652 1
Toxoplasma gondii beta tubulin 0.003 0.0051 0.0716
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0041 0.0087 0.0238
Trichomonas vaginalis PIKK family atypical protein kinase 0.0212 0.0652 1
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0041 0.0087 0.1273
Leishmania major beta tubulin 0.003 0.0051 0.0129
Trichomonas vaginalis PIKK family atypical protein kinase 0.0212 0.0652 1
Trichomonas vaginalis tubulin alpha chain, putative 0.003 0.0051 0.0716
Trypanosoma cruzi hypothetical protein, conserved 0.1062 0.3466 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0041 0.0087 0.1273
Entamoeba histolytica protein kinase rad3, putative 0.0119 0.0347 0.5288
Trichomonas vaginalis PIKK family atypical protein kinase 0.0212 0.0652 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0041 0.0087 0.1273
Leishmania major beta tubulin 0.003 0.0051 0.0129
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0119 0.0347 0.0345
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0078 0.5844
Giardia lamblia Phosphatidylinositol 4-kinase 0.0041 0.0087 0.0599
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0016 0.0004 0.0002
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0109 0.0313 0.4768
Onchocerca volvulus 0.0031 0.0055 0.4074
Leishmania major phosphatidylinositol 3-kinase, putative 0.0041 0.0087 0.0229
Loa Loa (eye worm) hypothetical protein 0.0041 0.0087 0.1329
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0041 0.0087 0.1273
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0041 0.0087 0.1273
Loa Loa (eye worm) RNA binding protein 0.0073 0.0195 0.299
Schistosoma mansoni hypothetical protein 0.0045 0.0101 0.15
Trypanosoma cruzi beta tubulin, putative 0.003 0.0051 0.0134
Entamoeba histolytica hypothetical protein 0.0041 0.0087 0.1273
Leishmania major beta tubulin 0.003 0.0051 0.0129
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0065
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0133 0.0392 0.5984
Leishmania major phosphatidylinositol 4-kinase, putative 0.0041 0.0087 0.0229
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0212 0.0652 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0212 0.0652 1
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0041 0.0087 0.0085
Trichomonas vaginalis PIKK family atypical protein kinase 0.0119 0.0347 0.5288
Leishmania major beta tubulin 0.003 0.0051 0.0129
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0016 0.0004 0.0065
Plasmodium vivax acyl-CoA synthetase, putative 0.004 0.0085 0.9786
Trichomonas vaginalis PIKK family atypical protein kinase 0.0119 0.0347 0.5288
Schistosoma mansoni lamin 0.0031 0.0055 0.079
Loa Loa (eye worm) tubulin beta-2A chain 0.003 0.0051 0.0776
Leishmania major beta tubulin 0.003 0.0051 0.0129
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0055 0.085
Loa Loa (eye worm) hypothetical protein 0.0054 0.013 0.1992
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0133 0.0392 0.5984
Echinococcus multilocularis lamin 0.0031 0.0055 0.0054
Echinococcus granulosus Tubulin beta 2C chain 0.003 0.0051 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0212 0.0652 1
Plasmodium vivax hypothetical protein 0.0041 0.0087 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.004 0.0085 0.6421
Leishmania major beta tubulin 0.003 0.0051 0.0129
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0041 0.0087 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0119 0.0347 0.5288
Schistosoma mansoni hypothetical protein 0.0092 0.0257 0.3905
Brugia malayi Niemann-Pick C1 protein precursor 0.0109 0.0313 0.4768
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0041 0.0087 0.1273
Echinococcus multilocularis musashi 0.0031 0.0055 0.0054
Brugia malayi RNA recognition motif domain containing protein 0.0073 0.0195 0.2944
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0119 0.0347 0.5288
Echinococcus multilocularis Tubulin beta 2C chain 0.003 0.0051 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0212 0.0652 1
Echinococcus granulosus expressed conserved protein 0.0103 0.0291 0.0289
Trichomonas vaginalis PIKK family atypical protein kinase 0.0212 0.0652 1
Brugia malayi Tubulin beta-1 chain 0.003 0.0051 0.0716
Schistosoma mansoni tubulin subunit beta 0.003 0.0051 0.0716
Trichomonas vaginalis PIKK family atypical protein kinase 0.0212 0.0652 1
Mycobacterium ulcerans hypothetical protein 0.0054 0.013 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0119 0.0347 0.5288
Trichomonas vaginalis tubulin gamma chain, putative 0.003 0.0051 0.0716
Entamoeba histolytica hypothetical protein 0.0041 0.0087 0.1273
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0054 0.013 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0212 0.0652 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0212 0.0652 0.1801
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0054 0.013 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0212 0.0652 1
Plasmodium vivax tubulin beta chain, putative 0.003 0.0051 0.5628
Loa Loa (eye worm) phosphatidylinositol 3 0.0041 0.0087 0.1329
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0041 0.0087 0.0238
Echinococcus granulosus sterol regulatory element binding protein 0.0047 0.0107 0.0105
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0054 0.013 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0047 0.0107 0.164
Echinococcus granulosus tar DNA binding protein 0.0073 0.0195 0.0193
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0041 0.0087 0.1273
Echinococcus multilocularis beta tubulin 0.003 0.0051 0.0049
Leishmania major beta tubulin 0.003 0.0051 0.0129
Echinococcus granulosus serine protein kinase ATM 0.0119 0.0347 0.0345
Trichomonas vaginalis PIKK family atypical protein kinase 0.0212 0.0652 1
Trypanosoma brucei beta tubulin 0.003 0.0051 0.0716
Trypanosoma brucei beta tubulin 0.003 0.0051 0.0716
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0212 0.0652 0.065
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0041 0.0087 0.0085
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0041 0.0087 0.1273
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0041 0.0087 0.1273
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0212 0.0652 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0212 0.0652 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0054 0.0821
Loa Loa (eye worm) phosphatidylinositol 3 0.0041 0.0087 0.1329
Entamoeba histolytica hypothetical protein 0.0119 0.0347 0.5288
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0195 0.2944
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0041 0.0087 0.1273
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0195 0.2944
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0016 0.0004 0.0065
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0041 0.0087 0.0238
Toxoplasma gondii target of rapamycin (TOR), putative 0.0212 0.0652 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0119 0.0347 0.5288
Brugia malayi FAT domain containing protein 0.0092 0.0257 0.3905
Leishmania major beta tubulin 0.003 0.0051 0.0129
Echinococcus granulosus tubulin beta 4A class IVa 0.003 0.0051 0.0049
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0054 0.013 1
Leishmania major phosphatidylinositol kinase related protein, putative 0.0041 0.0087 0.0229
Giardia lamblia Hypothetical protein 0.0041 0.0087 0.0599
Loa Loa (eye worm) hypothetical protein 0.004 0.0085 0.1302
Echinococcus multilocularis lamin dm0 0.0031 0.0055 0.0054
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0041 0.0087 0.0238
Echinococcus granulosus tubulin beta 1 chain 0.003 0.0051 0.0049
Leishmania major beta tubulin 0.003 0.0051 0.0129
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0041 0.0087 1
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0195 0.2944
Trichomonas vaginalis PIKK family atypical protein kinase 0.0119 0.0347 0.5288
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0111 0.0319 0.4854
Loa Loa (eye worm) BEN-1 protein 0.003 0.0051 0.0776
Echinococcus multilocularis Tubulin beta 2C chain 0.003 0.0051 0.0049
Echinococcus multilocularis sterol regulatory element binding protein 0.0047 0.0107 0.0105
Echinococcus multilocularis Tubulin beta 2C chain 0.003 0.0051 0.0049
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0041 0.0087 0.1273
Entamoeba histolytica tubulin family protein 0.003 0.0051 0.0716
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0041 0.0087 0.1273
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0092 0.0257 0.0255
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0041 0.0087 0.1273
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0041 0.0087 0.1273
Loa Loa (eye worm) hypothetical protein 0.0079 0.0212 0.3253
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0041 0.0087 0.1273
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0041 0.0087 0.1273
Leishmania major phosphatidylinositol kinase, putative 0.0041 0.0087 0.0229
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0212 0.0652 0.065
Leishmania major beta tubulin 0.003 0.0051 0.0129
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.0392 0.5984
Trichomonas vaginalis PIKK family atypical protein kinase 0.0212 0.0652 1
Loa Loa (eye worm) phosphatidylinositol kinase 0.0041 0.0087 0.1329
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0041 0.0087 0.1273
Echinococcus multilocularis 0.0041 0.0087 0.0085
Trichomonas vaginalis PIKK family atypical protein kinase 0.0212 0.0652 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0054 0.013 1
Toxoplasma gondii beta-1 tubulin, putative 0.003 0.0051 0.0716
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0107 0.1586
Loa Loa (eye worm) phosphatidylinositol 3 0.0041 0.0087 0.1329
Schistosoma mansoni intermediate filament proteins 0.0031 0.0055 0.079
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0016 0.0004 0.0002
Schistosoma mansoni hypothetical protein 0.0045 0.0101 0.15
Trichomonas vaginalis PIKK family atypical protein kinase 0.0212 0.0652 1
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0007 0.0049
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0041 0.0087 0.1273
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0119 0.0347 0.5288
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0212 0.0652 1
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0041 0.0087 0.1329
Trichomonas vaginalis PIKK family atypical protein kinase 0.0212 0.0652 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.003 0.0051 0.0716
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0041 0.0087 0.1273
Loa Loa (eye worm) hypothetical protein 0.004 0.0085 0.1302
Leishmania major beta tubulin 0.003 0.0051 0.0129
Trichomonas vaginalis PIKK family atypical protein kinase 0.0133 0.0392 0.5984
Loa Loa (eye worm) phosphatidylinositol 3 0.0041 0.0087 0.1329
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0119 0.0347 0.0989
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0212 0.3209
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0041 0.0087 0.0085
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0041 0.0087 0.1273
Toxoplasma gondii FATC domain-containing protein 0.0119 0.0347 0.5288
Brugia malayi beta-tubulin, identical 0.003 0.0051 0.0716
Trichomonas vaginalis tubulin epsilon chain, putative 0.003 0.0051 0.0716
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0041 0.0087 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0212 0.0652 1
Echinococcus granulosus Tubulin beta 2C chain 0.003 0.0051 0.0049
Loa Loa (eye worm) hypothetical protein 0.004 0.0085 0.1302
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0041 0.0087 0.1273
Loa Loa (eye worm) hypothetical protein 0.0041 0.0087 0.1329
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0055 0.079
Brugia malayi AMP-binding enzyme family protein 0.0054 0.013 0.194
Entamoeba histolytica hypothetical protein 0.0041 0.0087 0.1273
Schistosoma mansoni tubulin subunit beta 0.003 0.0051 0.0716
Echinococcus multilocularis tubulin subunit beta 0.003 0.0051 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0212 0.0652 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0119 0.0347 0.5288
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0087 0.1273
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0119 0.0347 0.0989
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0212 0.0652 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0087 0.6562
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0041 0.0087 0.1273
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0041 0.0087 0.0085
Leishmania major 4-coumarate:coa ligase-like protein 0.0054 0.013 0.0349
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0087 1
Loa Loa (eye worm) TAR-binding protein 0.0073 0.0195 0.299
Echinococcus granulosus Niemann Pick C1 protein 0.0156 0.0468 0.0466
Echinococcus granulosus Protein patched homolog 1 0.0047 0.0107 0.0105
Trichomonas vaginalis PIKK family atypical protein kinase 0.0212 0.0652 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0054 0.013 0.0349
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0041 0.0087 0.0085
Brugia malayi RNA binding protein 0.0073 0.0195 0.2944
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0212 0.0652 1
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0041 0.0087 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.004 0.0085 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0212 0.0652 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0073 0.0195 0.299
Loa Loa (eye worm) tubulin beta-4 chain 0.003 0.0051 0.0776
Echinococcus granulosus lamin dm0 0.0031 0.0055 0.0054
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0041 0.0087 0.0085
Leishmania major hypothetical protein, unknown function 0.0041 0.0087 0.0229
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0041 0.0087 0.1273
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.3037 1 1
Brugia malayi intermediate filament protein 0.0031 0.0055 0.079
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0041 0.0087 0.1273
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0212 0.0652 1
Schistosoma mansoni tubulin subunit beta 0.003 0.0051 0.0716
Trichomonas vaginalis PIKK family atypical protein kinase 0.0212 0.0652 1
Onchocerca volvulus 0.0054 0.013 1
Leishmania major beta tubulin 0.003 0.0051 0.0129
Loa Loa (eye worm) hypothetical protein 0.0054 0.013 0.1992
Trichomonas vaginalis PIKK family atypical protein kinase 0.0212 0.0652 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0212 0.0652 0.065
Loa Loa (eye worm) hypothetical protein 0.0057 0.0142 0.2175
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0041 0.0087 0.0238
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0212 0.0652 0.1871
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0041 0.0087 0.1273
Leishmania major hypothetical protein, conserved 0.1103 0.3601 1
Schistosoma mansoni tubulin subunit beta 0.003 0.0051 0.0716
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0041 0.0087 0.1273
Echinococcus granulosus beta tubulin 0.003 0.0051 0.0049
Brugia malayi AMP-binding enzyme family protein 0.0054 0.013 0.194
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0041 0.0087 0.0085
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0041 0.0087 0.1273
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0041 0.0087 0.0238
Loa Loa (eye worm) hypothetical protein 0.0047 0.0107 0.164
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0041 0.0087 0.1273
Trichomonas vaginalis PIKK family atypical protein kinase 0.0212 0.0652 1
Echinococcus granulosus intermediate filament protein 0.0031 0.0055 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0212 0.0652 1
Echinococcus multilocularis tubulin beta 1 chain 0.003 0.0051 0.0049
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0041 0.0087 0.0085
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0041 0.0087 0.0085
Echinococcus multilocularis protein patched 0.0047 0.0107 0.0105
Trichomonas vaginalis PIKK family atypical protein kinase 0.0119 0.0347 0.5288
Echinococcus granulosus Tubulin beta 2C chain 0.003 0.0051 0.0049
Mycobacterium ulcerans acyl-CoA synthetase 0.0054 0.013 1
Schistosoma mansoni hypothetical protein 0.0045 0.0101 0.15
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0212 0.0652 0.1871
Entamoeba histolytica acyl-CoA synthetase, putative 0.0054 0.013 0.194
Leishmania major phosphatidylinositol 3-kinase, putative 0.0212 0.0652 0.1801
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0041 0.0087 0.1273
Trichomonas vaginalis PIKK family atypical protein kinase 0.0119 0.0347 0.5288
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0041 0.0087 0.1273
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0078 0.5844
Entamoeba histolytica acyl-coA synthetase, putative 0.0054 0.013 0.194
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0212 0.0652 0.1801
Loa Loa (eye worm) tubulin beta-1 chain 0.003 0.0051 0.0776
Loa Loa (eye worm) hypothetical protein 0.004 0.0085 0.1302
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0212 0.0652 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0054 0.013 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0212 0.0652 1
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0041 0.0087 0.0238
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0041 0.0087 0.0085
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0195 0.2944

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 71 % Displacement of [3H]colchicine from tubulin at 5 uM ChEMBL. 17685504
Activity (binding) = 71 % Displacement of [3H]colchicine from tubulin at 5 uM ChEMBL. 17685504
IC50 (functional) = 88 nM Growth inhibition of human MKN45 cells after 72 hrs by methylene blue dye assay ChEMBL. 17685504
IC50 (functional) = 88 nM Growth inhibition of human MKN45 cells after 72 hrs by methylene blue dye assay ChEMBL. 17685504
IC50 (functional) = 100 nM Growth inhibition of human HT29 cells after 72 hrs by methylene blue dye assay ChEMBL. 17685504
IC50 (functional) = 100 nM Growth inhibition of human HT29 cells after 72 hrs by methylene blue dye assay ChEMBL. 17685504
IC50 (functional) = 103 nM Growth inhibition of human TSGH cells after 72 hrs by methylene blue dye assay ChEMBL. 17685504
IC50 (functional) = 103 nM Growth inhibition of human TSGH cells after 72 hrs by methylene blue dye assay ChEMBL. 17685504
IC50 (functional) = 104 nM Growth inhibition of human KB cells after 72 hrs by methylene blue dye assay ChEMBL. 17685504
IC50 (functional) = 104 nM Growth inhibition of human KB cells after 72 hrs by methylene blue dye assay ChEMBL. 17685504
IC50 (functional) = 111 nM Growth inhibition of human KB-vin10 cells after 72 hrs by methylene blue dye assay ChEMBL. 17685504
IC50 (functional) = 112 nM Growth inhibition of human H460 cells after 72 hrs by methylene blue dye assay ChEMBL. 17685504
IC50 (functional) = 112 nM Growth inhibition of human H460 cells after 72 hrs by methylene blue dye assay ChEMBL. 17685504
IC50 (functional) = 225 nM Antiproliferative activity against human CEM cells ChEMBL. 17482458
IC50 (functional) = 225 nM Antiproliferative activity against human CEM cells ChEMBL. 17482458
IC50 (binding) = 2.2 uM Inhibition of tubulin polymerization in presence of microtubule associated proteins after 30 mins ChEMBL. 17685504
IC50 (binding) = 2.2 uM Inhibition of tubulin polymerization in presence of microtubule associated proteins after 30 mins ChEMBL. 17685504

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 17482458

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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