Detailed information for compound 433577

Basic information

Technical information
  • TDR Targets ID: 433577
  • Name: 8-chloro-4-(3-chloro-4-fluoroanilino)-6-(2H-t etrazol-5-ylmethylamino)quinoline-3-carbonitr ile
  • MW: 429.238 | Formula: C18H11Cl2FN8
  • H donors: 3 H acceptors: 5 LogP: 4.42 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1cnc2c(c1Nc1ccc(c(c1)Cl)F)cc(cc2Cl)NCc1n[nH]nn1
  • InChi: 1S/C18H11Cl2FN8/c19-13-4-10(1-2-15(13)21)25-17-9(6-22)7-24-18-12(17)3-11(5-14(18)20)23-8-16-26-28-29-27-16/h1-5,7,23H,8H2,(H,24,25)(H,26,27,28,29)
  • InChiKey: IPSFZCMYKQHAMQ-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • 8-chloro-4-(3-chloro-4-fluoro-anilino)-6-(2H-tetrazol-5-ylmethylamino)quinoline-3-carbonitrile
  • 8-chloro-4-(3-chloro-4-fluoroanilino)-6-(2H-tetrazol-5-ylmethylamino)-3-quinolinecarbonitrile
  • 8-chloro-4-[(3-chloro-4-fluoro-phenyl)amino]-6-(2H-1,2,3,4-tetrazol-5-ylmethylamino)quinoline-3-carbonitrile

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase kinase kinase 8 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0025 0.0088 0.0088
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0013 0.0009 0.0021
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.001 0.0014
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0073 0.0383
Schistosoma mansoni survival motor neuron protein 0.0053 0.0267 0.0267
Echinococcus granulosus FTZ F1 alpha 0.0025 0.0088 0.0088
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.009 0.0511 0.0511
Loa Loa (eye worm) hypothetical protein 0.0025 0.0088 0.0196
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0073 0.0383
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0286 0.2623
Onchocerca volvulus 0.006 0.0311 0.2044
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.02 0.0439
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0025 0.0088 0.0196
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0013 0.0009 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0025 0.0088 0.0196
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0025 0.0088 0.0088
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0073 0.0383
Mycobacterium ulcerans acyl-CoA synthetase 0.0079 0.0438 0.4183
Schistosoma mansoni inositol monophosphatase 0.0043 0.02 0.02
Mycobacterium ulcerans acyl-CoA synthetase 0.0079 0.0438 0.4183
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0025 0.0088 0.0088
Toxoplasma gondii macrophage migration inhibitory factor, putative 0.0697 0.4473 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0321 0.2016 0.4503
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.001 0.0014
Loa Loa (eye worm) FYVE finger-containing phosphoinositide kinase 0.0013 0.0004 0.0008
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.013 0.013
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.001 0.0014
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0286 0.2623
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0025 0.0088 0.0196
Toxoplasma gondii Erv1 / Alr family protein 0.0035 0.0152 0.0332
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.013 0.013
Echinococcus granulosus inositol monophosphatase 1 0.0043 0.02 0.02
Brugia malayi Isocitrate dehydrogenase 0.0033 0.014 0.0314
Loa Loa (eye worm) histone methyltransferase 0.002 0.0049 0.011
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0074 0.0386
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0089 0.0192
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.02 0.1082
Schistosoma mansoni thyroid hormone receptor 0.0025 0.0088 0.0088
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0073 0.0163
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0156 0.0943 0.0943
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0048 0.0107
Echinococcus multilocularis cpg binding protein 0.0063 0.0333 0.0333
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.011 0.0238
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0174 0.1056 0.6945
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.009 0.0511 0.1135
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.029 0.1819 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0031 0.0125 0.0271
Leishmania major mitochondrial DNA polymerase beta 0.029 0.1819 0.4062
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0059 0.0307 0.2859
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0245 0.0245
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0023 0.0073 0.0383
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0025 0.0088 0.0088
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0023 0.0073 0.0236
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0321 0.2016 0.4503
Loa Loa (eye worm) hypothetical protein 0.0079 0.0438 0.0979
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0311 0.0695
Echinococcus granulosus dnaJ subfamily B 0.0848 0.5464 0.5464
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0073 0.0163
Plasmodium falciparum importin beta, putative 0.0032 0.0128 0.0279
Brugia malayi Calcitonin receptor-like protein seb-1 0.0158 0.0953 0.213
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type I 0.0013 0.0004 0.0004
Trichomonas vaginalis alpha-glucosidase, putative 0.0077 0.0427 0.0947
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0025 0.0088 0.0088
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.0073 0.0156
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0026 0.0026
Brugia malayi hypothetical protein 0.0013 0.0009 0.0021
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0025 0.0088 0.0088
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0338 0.2127 0.4756
Leishmania major alpha glucosidase II subunit, putative 0.0077 0.0427 0.0947
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0079 0.0438 0.4183
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0035 0.0152 0.0817
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0023 0.0073 0.0236
Entamoeba histolytica acyl-CoA synthetase, putative 0.0079 0.0438 0.0971
Brugia malayi Bm-MIF-1, identical 0.0697 0.4473 1
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0035 0.0152 0.0152
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.0073 0.0236
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0088 0.0088
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0026 0.0026
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0245 0.0245
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0337 0.0337
Brugia malayi nuclear hormone receptor 0.0025 0.0088 0.0196
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0073 0.0236
Loa Loa (eye worm) hypothetical protein 0.0032 0.013 0.0292
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0337 0.0337
Loa Loa (eye worm) hypothetical protein 0.005 0.0248 0.0554
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0038 0.0171 0.1119
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0101 0.0219
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0049 0.0049
Echinococcus granulosus cpg binding protein 0.0063 0.0333 0.0333
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0188 0.1018
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0035 0.0152 0.0332
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0002 0.0002
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.014 0.014
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0025 0.0088 0.0088
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.013 0.013
Echinococcus multilocularis ecdysone induced protein 78C 0.0025 0.0088 0.0088
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0079 0.0438 0.4183
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0031 0.0125 0.059
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0245 0.0548
Echinococcus multilocularis microtubule associated protein 2 0.1543 1 1
Brugia malayi nuclear receptor RXR 0.0013 0.0009 0.0021
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0188 0.1018
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0074 0.0074
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0321 0.2016 0.4503
Schistosoma mansoni hypothetical protein 0.0012 0.0002 0.0002
Plasmodium falciparum macrophage migration inhibitory factor 0.0697 0.4473 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0073 0.0163
Loa Loa (eye worm) hypothetical protein 0.0025 0.0088 0.0196
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.001 0.0014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0245 0.0245
Toxoplasma gondii hypothetical protein 0.0031 0.0125 0.0271
Schistosoma mansoni ran 0.0023 0.0074 0.0074
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0013 0.0009 0.0009
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.014 0.014
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0089 0.0472
Loa Loa (eye worm) hypothetical protein 0.0059 0.0307 0.0687
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0059 0.0307 0.2686
Echinococcus multilocularis lysosomal alpha glucosidase 0.0349 0.2199 0.2199
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0079 0.0438 0.4183
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0321 0.2016 0.4503
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0023 0.0073 0.0073
Echinococcus granulosus Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0013 0.0004 0.0004
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0286 0.2623
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0033 0.014 0.099
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.014 0.014
Brugia malayi Latrophilin receptor protein 2 0.005 0.0248 0.0554
Onchocerca volvulus 0.0025 0.0088 0.0578
Schistosoma mansoni retinoic acid receptor RXR 0.0025 0.0088 0.0088
Schistosoma mansoni RAR-like nuclear receptor 0.0025 0.0088 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.001 0.0014
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0023 0.0073 0.0236
Trypanosoma brucei glycosyl hydrolase-like protein 0.0029 0.011 0.0585
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0074 0.0386
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0023 0.0073 0.0236
Toxoplasma gondii Erv1 / Alr family protein 0.0035 0.0152 0.0332
Leishmania major macrophage migration inhibitory factor-like protein 0.0697 0.4473 1
Loa Loa (eye worm) pip kinase 1 0.0013 0.0004 0.0008
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.0073 0.0156
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.0073 0.0156
Mycobacterium ulcerans hypothetical protein 0.0153 0.0921 0.9727
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0013 0.0009 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0025 0.0088 0.0196
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.009 0.0511 0.5021
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0162 0.0162
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.011 0.0238
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.001 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0025 0.0088 0.0196
Brugia malayi hypothetical protein 0.0259 0.1616 0.3613
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0321 0.2016 0.4503
Brugia malayi hypothetical protein 0.0028 0.0101 0.0227
Trichomonas vaginalis maltase-glucoamylase, putative 0.0077 0.0427 0.0947
Echinococcus granulosus survival motor neuron protein 1 0.0259 0.1616 0.1616
Trichomonas vaginalis ran, putative 0.0023 0.0074 0.0157
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.009 0.0511 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0077 0.0427 0.0947
Leishmania major macrophage migration inhibitory factor-like protein 0.0697 0.4473 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0157 0.0945 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0088 0.0088
Entamoeba histolytica hypothetical protein 0.0026 0.0089 0.0192
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0023 0.0073 0.0236
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0259 0.1616 0.3613
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0033 0.014 0.0306
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0074 0.0157
Brugia malayi Glycosyl hydrolases family 31 protein 0.0077 0.0427 0.0954
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.0073 0.0156
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.011 0.0238
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0021
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0025 0.0088 0.0088
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0063 0.0336 0.1833
Loa Loa (eye worm) hypothetical protein 0.0032 0.0128 0.0287
Giardia lamblia Macrophage migration inhibitory factor 0.0697 0.4473 1
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0073 0.0156
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.0088 0.0196
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0089 0.0192
Echinococcus multilocularis FTZ F1 alpha 0.0025 0.0088 0.0088
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0025 0.0088 0.0196
Brugia malayi Pre-SET motif family protein 0.0032 0.013 0.0292
Loa Loa (eye worm) hypothetical protein 0.0025 0.0088 0.0196
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0248 0.0554
Toxoplasma gondii hypothetical protein 0.0047 0.0228 0.0501
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.001 0.0014
Schistosoma mansoni hypothetical protein 0.005 0.0248 0.0248
Brugia malayi Glycosyl hydrolases family 31 protein 0.0029 0.011 0.0245
Toxoplasma gondii propionate-CoA ligase 0.0023 0.0073 0.0156
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0156 0.0943 0.0943
Loa Loa (eye worm) hypothetical protein 0.0079 0.0438 0.0979
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0321 0.2016 0.4503
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0297 0.1863 0.4165
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0245 0.0245
Echinococcus granulosus lysosomal alpha glucosidase 0.0349 0.2199 0.2199
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0337 0.0746
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0025 0.0088 0.0196
Schistosoma mansoni phosphatidylinositol-4-phosphate-5-kinaseputativ e 0.0013 0.0004 0.0004
Trichomonas vaginalis alpha-glucosidase, putative 0.0077 0.0427 0.0947
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0025 0.0088 0.0196
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0026 0.0026
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0077 0.0427 0.0947
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.02 0.0439
Loa Loa (eye worm) hypothetical protein 0.0025 0.0088 0.0196
Entamoeba histolytica macrophage migration inhibitory factor-like protein 0.0697 0.4473 1
Loa Loa (eye worm) FYVE zinc finger family protein 0.0013 0.0004 0.0008
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0063 0.0336 0.0336
Brugia malayi FYVE finger-containing phosphoinositide kinase, putative 0.0013 0.0004 0.0008
Leishmania major glycosyl hydrolase-like protein 0.0029 0.011 0.0238
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0063 0.0336 0.0336
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0079 0.0438 0.4183
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0025 0.0088 0.0196
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0101 0.054
Brugia malayi Importin beta-1 subunit 0.0032 0.0128 0.0287
Mycobacterium tuberculosis Conserved hypothetical protein 0.0153 0.0921 0.9733
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.013 0.013
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0128 0.0687
Schistosoma mansoni coup transcription factor 0.0025 0.0088 0.0088
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.014 0.014
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0023 0.0073 0.0156
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.02 0.0439
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0156 0.0943 0.0943
Brugia malayi AMP-binding enzyme family protein 0.0079 0.0438 0.0979
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.001 0.0014
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0035 0.0152 0.0332
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0079 0.0438 0.4183
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0137 0.0819 0.4495
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0025 0.0088 0.0088
Echinococcus multilocularis dnaJ subfamily B 0.0848 0.5464 0.5464
Brugia malayi latrophilin 2 splice variant baaae 0.0108 0.0627 0.1401
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.1327 0.2967
Loa Loa (eye worm) hypothetical protein 0.0059 0.0307 0.0687
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0128 0.0687
Schistosoma mansoni importin beta-1 0.0032 0.0128 0.0128
Brugia malayi Steroid receptor seven-up type 2 0.0025 0.0088 0.0196
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0063 0.0336 0.0752
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0079 0.0438 0.4321
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0247 0.134
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.014 0.0314
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0035 0.0152 0.0817
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0188 0.1018
Loa Loa (eye worm) hypothetical protein 0.0023 0.0073 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.001 0.0014
Loa Loa (eye worm) pip kinase 2 0.0156 0.0943 0.2107
Loa Loa (eye worm) hypothetical protein 0.0029 0.011 0.0245
Schistosoma mansoni thyroid hormone receptor 0.0025 0.0088 0.0088
Brugia malayi Nuclear hormone receptor-like 1 0.0013 0.0009 0.0021
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0158 0.0953 0.213
Echinococcus multilocularis inositol monophosphatase 1 0.0043 0.02 0.02
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0025 0.0088 0.0196
Brugia malayi CXXC zinc finger family protein 0.006 0.0311 0.0695
Schistosoma mansoni alpha-glucosidase 0.03 0.1882 0.1882
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.02 0.1082
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.001 0.0014
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0077 0.0427 0.0947
Trichomonas vaginalis inositol monophosphatase, putative 0.0043 0.02 0.0439
Mycobacterium ulcerans acyl-CoA synthetase 0.0079 0.0438 0.4183
Schistosoma mansoni peptidase Clp (S14 family) 0.009 0.0511 0.0511
Treponema pallidum fructose-bisphosphate aldolase 0.0321 0.2016 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0088 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0025 0.0088 0.0196
Onchocerca volvulus Protein ultraspiracle homolog 0.0025 0.0088 0.0578
Leishmania major GTP-binding protein, putative 0.0023 0.0074 0.0157
Echinococcus granulosus peptidase Clp S14 family 0.0059 0.0308 0.0308
Loa Loa (eye worm) hepatopoietin HPO2 0.0035 0.0152 0.0339
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0023 0.0073 0.0163
Brugia malayi AMP-binding enzyme family protein 0.0079 0.0438 0.0979
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.009 0.0511 0.5021
Loa Loa (eye worm) macrophage migration inhibitory factor 0.0697 0.4473 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0188 0.1018
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0245 0.0548
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.011 0.0238
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0089 0.0192
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.0073 0.0383
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0248 0.0248
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0248 0.0248
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0321 0.2016 0.4503
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0321 0.2016 0.4503
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.009 0.0511 1
Echinococcus multilocularis phosphatidylinositol phosphate 5 kinase type III 0.0013 0.0004 0.0004
Brugia malayi Pip kinase protein 2 0.0156 0.0943 0.2107
Plasmodium vivax SET domain protein, putative 0.0032 0.013 0.0284
Trichomonas vaginalis maltase-glucoamylase, putative 0.0029 0.011 0.0238
Loa Loa (eye worm) hypothetical protein 0.0156 0.0943 0.2107
Loa Loa (eye worm) hypothetical protein 0.0059 0.0307 0.0687
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.001 0.0014
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0079 0.0438 0.4321
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0073 0.0236
Plasmodium vivax macrophage migration inhibitory factor, putative 0.0697 0.4473 1
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0035 0.0152 0.0817
Brugia malayi hypothetical protein 0.0018 0.0038 0.0084
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0245 0.0245
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.014 0.014
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0029 0.011 0.0238
Schistosoma mansoni hypothetical protein 0.005 0.0248 0.0248
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0043 0.02 0.1454
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0025 0.0088 0.0196
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0025 0.0088 0.0088
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0156 0.0943 0.0943
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.001 0.0014
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.014 0.014
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0245 0.0245
Giardia lamblia Fructose-bisphosphate aldolase 0.0321 0.2016 0.4503
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0059 0.0308 0.2692
Echinococcus multilocularis thyroid hormone receptor alpha 0.0025 0.0088 0.0088
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0074 0.0165
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0013 0.0009 0.0009
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0337 0.0746
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0077 0.0427 0.0947
Echinococcus granulosus snurportin 1 0.0338 0.2127 0.2127
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0063 0.0336 0.1833
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0074 0.0386
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0063 0.0336 0.0744
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0073 0.0163
Plasmodium vivax acetyl-CoA synthetase, putative 0.0023 0.0073 0.0156
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0073 0.0236
Brugia malayi AMP-binding enzyme family protein 0.0079 0.0438 0.0979
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0025 0.0088 0.0088
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0101 0.0219
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0025 0.0088 0.0088
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.009 0.0511 0.2042
Brugia malayi ecdysteroid receptor 0.0025 0.0088 0.0196
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0115 0.0115
Leishmania major hypothetical protein, conserved 0.0035 0.0152 0.0332
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0029 0.011 0.0585
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0026 0.0026
Onchocerca volvulus 0.0023 0.0073 0.0481
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0029 0.011 0.0585
Loa Loa (eye worm) hypothetical protein 0.0059 0.0307 0.0687
Schistosoma mansoni hypothetical protein 0.0338 0.2127 0.2127
Plasmodium falciparum acyl-CoA synthetase 0.0059 0.0307 0.068
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0137 0.0819 0.4495
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0162 0.0162
Leishmania major 4-coumarate:coa ligase-like protein 0.0079 0.0438 0.0971
Schistosoma mansoni hypothetical protein 0.005 0.0248 0.0248
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0079 0.0438 0.4183
Brugia malayi RNA, U transporter 1 0.009 0.0509 0.1138
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0427 0.2332
Leishmania major hypothetical protein, conserved 0.0028 0.0101 0.0219
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0025 0.0088 0.0196
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0137 0.0819 0.1826
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0063 0.0336 0.1833
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0063 0.0336 0.0744
Echinococcus multilocularis neutral alpha glucosidase AB 0.0077 0.0427 0.0427
Trichomonas vaginalis alpha-glucosidase, putative 0.0077 0.0427 0.0947
Loa Loa (eye worm) hypothetical protein 0.0025 0.0088 0.0196
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0267 0.0597
Loa Loa (eye worm) hypothetical protein 0.0108 0.0627 0.1401
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.014 0.0754
Trypanosoma brucei mitochondrial DNA polymerase beta 0.029 0.1819 1
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0023 0.0073 0.0156
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.014 0.0754
Echinococcus multilocularis survival motor neuron protein 1 0.0259 0.1616 0.1616
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0035 0.0152 0.0152
Brugia malayi Augmenter of liver regeneration 0.0035 0.0152 0.0339
Brugia malayi N-terminal motif family protein 0.0174 0.1056 0.236
Loa Loa (eye worm) oxidoreductase 0.0023 0.0073 0.0163
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.014 0.0306
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0025 0.0088 0.0196
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0935 0.6031 0.6031
Schistosoma mansoni steroid hormone receptor ad4bp 0.0025 0.0088 0.0088
Onchocerca volvulus 0.0023 0.0073 0.0481
Loa Loa (eye worm) hypothetical protein 0.0023 0.0073 0.0163
Brugia malayi Pip kinase protein 1 0.0013 0.0004 0.0008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0321 0.2016 0.4503
Schistosoma mansoni cpg binding protein 0.0063 0.0333 0.0333
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.014 0.0754
Echinococcus multilocularis Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0013 0.0004 0.0004
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0158 0.0953 0.213
Echinococcus multilocularis snurportin 1 0.0338 0.2127 0.2127
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0013 0.0004 0.0004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.001 0.0014
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0157 0.0945 1
Brugia malayi Pre-SET motif family protein 0.0215 0.1327 0.2967
Loa Loa (eye worm) hypothetical protein 0.0079 0.0438 0.0979
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0077 0.0427 0.0954
Brugia malayi Nuclear hormone receptor-like 1 0.0013 0.0009 0.0021
Onchocerca volvulus 0.0245 0.152 1
Onchocerca volvulus 0.0023 0.0073 0.0481
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0033 0.014 0.0306
Onchocerca volvulus 0.0202 0.1239 0.8148
Onchocerca volvulus Bile acid receptor homolog 0.0025 0.0088 0.0578
Brugia malayi hypothetical protein 0.0013 0.0009 0.0021
Echinococcus multilocularis GPCR, family 2 0.005 0.0248 0.0248
Echinococcus granulosus neutral alpha glucosidase AB 0.0077 0.0427 0.0427
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0023 0.0073 0.0156
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0025 0.0088 0.0196
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0077 0.0427 0.0947
Schistosoma mansoni hypothetical protein 0.0053 0.0267 0.0267
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.014 0.0306
Trypanosoma brucei glucosidase, putative 0.0077 0.0427 0.2332
Echinococcus multilocularis lysosomal alpha glucosidase 0.0349 0.2199 0.2199
Trichomonas vaginalis helicase, putative 0.0013 0.001 0.0014
Loa Loa (eye worm) steroid hormone receptor 0.0025 0.0088 0.0196
Schistosoma mansoni hypothetical protein 0.0108 0.0627 0.0627
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.009 0.0511 0.1135
Schistosoma mansoni hypothetical protein 0.005 0.0248 0.0248
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.014 0.0306
Loa Loa (eye worm) inositol-1 0.0043 0.02 0.0447
Trichomonas vaginalis alpha-glucosidase, putative 0.0077 0.0427 0.0947
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0025 0.0088 0.0196
Loa Loa (eye worm) hypothetical protein 0.0025 0.0088 0.0196
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0245 0.0245
Brugia malayi Glycosyl hydrolases family 31 protein 0.0349 0.2199 0.4915
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0043 0.02 0.0439
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0023 0.0073 0.0156
Brugia malayi Probable ClpP-like protease 0.009 0.0511 0.1142
Leishmania major importin beta-1 subunit, putative 0.0026 0.0089 0.0192
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0023 0.0073 0.0073
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0029 0.011 0.0238
Trichomonas vaginalis macrophage migration inhibitory factor, mif, putative 0.0697 0.4473 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0021
Loa Loa (eye worm) hypothetical protein 0.0025 0.0088 0.0196
Leishmania major 4-coumarate:coa ligase-like protein 0.0079 0.0438 0.0971
Entamoeba histolytica acyl-coA synthetase, putative 0.0079 0.0438 0.0971
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0337 0.0337
Loa Loa (eye worm) hypothetical protein 0.0059 0.0307 0.0687
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0128 0.0279
Loa Loa (eye worm) hypothetical protein 0.0025 0.0088 0.0196
Entamoeba histolytica Ran family GTPase 0.0023 0.0074 0.0157
Plasmodium vivax acyl-CoA synthetase, putative 0.0059 0.0307 0.068
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0073 0.0163
Brugia malayi Inositol-1 0.0043 0.02 0.0447
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0349 0.2199 0.4915
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0088 0.0088
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0063 0.0336 0.0336
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.001 0.0014
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0029 0.011 0.0238
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.009 0.0511 0.1135
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.011 0.0238
Schistosoma mansoni cpg binding protein 0.0063 0.0333 0.0333
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.001 0.0014
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0427 0.2332
Trichomonas vaginalis conserved hypothetical protein 0.0697 0.4473 1
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0101 0.054
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0074 0.0074
Echinococcus granulosus importin subunit beta 1 0.0032 0.0128 0.0128
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0038 0.0171 0.1329
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0074 0.0157
Plasmodium vivax importin-beta 2, putative 0.0032 0.0128 0.0279
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0031 0.0125 0.0271
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0074 0.0165
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0101 0.0219
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0063 0.0336 0.0752
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.02 0.1082
Schistosoma mansoni cpg binding protein 0.006 0.0311 0.0311
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0337 0.3189
Loa Loa (eye worm) hypothetical protein 0.0158 0.0953 0.213
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0021
Brugia malayi photoreceptor-specific nuclear receptor 0.0025 0.0088 0.0196
Brugia malayi isocitrate dehydrogenase 0.0033 0.014 0.0314
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0337 0.0337
Schistosoma mansoni microtubule-associated protein tau 0.1543 1 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.013 0.0284
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0023 0.0073 0.0236
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0157 0.0945 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0059 0.0308 0.2865
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0286 0.2623
Onchocerca volvulus 0.0053 0.0267 0.1758
Toxoplasma gondii histone lysine methyltransferase SET1 0.0114 0.0666 0.1483
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.013 0.013
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.009 0.0511 0.0511
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0025 0.0088 0.0196
Entamoeba histolytica acyl-CoA synthetase, putative 0.0079 0.0438 0.0971
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0074 0.0157
Echinococcus granulosus GPCR family 2 0.005 0.0248 0.0248
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.0073 0.0383
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0074 0.0157
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0337 0.3025
Onchocerca volvulus 0.0032 0.013 0.0858
Loa Loa (eye worm) hypothetical protein 0.0028 0.0101 0.0227
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0029 0.011 0.0722
Echinococcus granulosus ecdysone induced protein 78C 0.0025 0.0088 0.0088
Schistosoma mansoni acetyl-CoA synthetase 0.0023 0.0073 0.0073
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0025 0.0088 0.0578
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0002 0.0002
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.009 0.0511 0.1135
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0025 0.0088 0.0196
Trichomonas vaginalis alpha-glucosidase, putative 0.0077 0.0427 0.0947
Loa Loa (eye worm) hypothetical protein 0.0174 0.1056 0.236
Schistosoma mansoni hypothetical protein 0.0848 0.5464 0.5464
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0337 0.3025
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0059 0.0308 0.2865
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0025 0.0088 0.0196
Onchocerca volvulus 0.0023 0.0073 0.0481
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0073 0.0163
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0021
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0073 0.0236
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0077 0.0427 0.0947
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.0073 0.0163
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0025 0.0088 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0025 0.0088 0.0196
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0025 0.0088 0.0088
Schistosoma mansoni alpha-glucosidase 0.03 0.1882 0.1882
Echinococcus granulosus phosphatidylinositol phosphate 5 kinase type III 0.0013 0.0004 0.0004
Onchocerca volvulus 0.0156 0.0943 0.6202
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0128 0.0128
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0025 0.0088 0.0088
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0101 0.0219
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.009 0.0511 0.5021
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.013 0.013
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0248 0.0248
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0043 0.02 0.0439
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0049 0.0049
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0101 0.054
Echinococcus multilocularis peptidase Clp (S14 family) 0.0059 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0021
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0013 0.0004 0.0004
Brugia malayi nuclear receptor NHR-88 0.0025 0.0088 0.0196
Loa Loa (eye worm) hypothetical protein 0.009 0.0511 0.1142
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0088 0.0088
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0033 0.014 0.0754
Trichomonas vaginalis set domain proteins, putative 0.0245 0.152 0.3393
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0127 0.0754 0.0754
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0035 0.0152 0.0817
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.001 0.0014
Onchocerca volvulus 0.0079 0.0438 0.288
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0248 0.0248
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.029 0.1819 1
Brugia malayi steroid hormone receptor 0.0025 0.0088 0.0196
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0337 0.3025
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.009 0.0511 1
Mycobacterium ulcerans hypothetical protein 0.0079 0.0438 0.4183
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.013 0.013
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.001 0.0014
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0248 0.0554
Schistosoma mansoni inositol monophosphatase 0.0043 0.02 0.02
Schistosoma mansoni ran 0.0023 0.0074 0.0074
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.014 0.014
Leishmania major 4-coumarate:coa ligase-like protein 0.0079 0.0438 0.0971
Schistosoma mansoni alpha glucosidase 0.0077 0.0427 0.0427
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0297 0.1863 0.4165
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0321 0.2016 0.4503

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) > 5000 nM Inhibition of LPS-stimulated TNFalpha production in monocytes ChEMBL. 17715908
Activity (functional) > 20000 nM Inhibition of LPS-stimulated TNFalpha production in human blood ChEMBL. 17715908
Activity (functional) > 20000 nM Inhibition of LPS-stimulated TNFalpha production in human blood ChEMBL. 17715908
IC50 (binding) = 2 nM Inhibition of Tpl2 by ELISA ChEMBL. 17715908
IC50 (binding) = 2 nM Inhibition of Tpl2 by ELISA ChEMBL. 17715908

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.