TDR Targets

Basic information

Technical information

TDR Targets ID: 433785
Name: 4-bromo-3-(carboxymethyloxy)-5-[3-(oxan-4-yla mino)phenyl]thiophene-2-carboxylic acid
MW: 456.308 | Formula: C18H18BrNO6S
H donors: 3 H acceptors: 4 LogP: 3.77 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)COc1c(Br)c(sc1C(=O)O)c1cccc(c1)NC1CCOCC1
InChi: 1S/C18H18BrNO6S/c19-14-15(26-9-13(21)22)17(18(23)24)27-16(14)10-2-1-3-12(8-10)20-11-4-6-25-7-5-11/h1-3,8,11,20H,4-7,9H2,(H,21,22)(H,23,24)
InChiKey: SEPNCGVQVYWECA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-bromo-3-(carboxymethyloxy)-5-[3-(tetrahydropyran-4-ylamino)phenyl]thiophene-2-carboxylic acid
4-bromo-3-(carboxymethyloxy)-5-[3-(4-tetrahydropyranylamino)phenyl]-2-thiophenecarboxylic acid
4-bromo-3-(carboxymethyloxy)-5-[3-(tetrahydropyran-4-ylamino)phenyl]-2-thenoic acid

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	protein tyrosine phosphatase, non-receptor type 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	Get druggable targets OG5_133865	All targets in OG5_133865
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	Get druggable targets OG5_133865	All targets in OG5_133865
Schistosoma japonicum	expressed protein	Get druggable targets OG5_133865	All targets in OG5_133865
Brugia malayi	Protein-tyrosine phosphatase containing protein	Get druggable targets OG5_133865	All targets in OG5_133865
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	Get druggable targets OG5_133865	All targets in OG5_133865
Loa Loa (eye worm)	protein-tyrosine phosphatase	Get druggable targets OG5_133865	All targets in OG5_133865
Schistosoma japonicum	ko:K05696 protein tyrosine phosphatase, non-receptor type 1, putative	Get druggable targets OG5_133865	All targets in OG5_133865

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	pcd6 interacting protein-related	0.0011	0.0044	0.0097
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0011	0.0044	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0044	0.0109
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0054	0.0132
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0054	0.0054
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0039	0.0095
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0072	0.0641	0.1587
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0011	0.0044	0.0109
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0246	0.3704
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0054	0.0132
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0011	0.0044	0.0044
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0011	0.0044	0.0109
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0011	0.0044	0.0044
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0072	0.0641	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0011	0.0044	0.0109
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0012	0.0054	0.0054
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0011	0.0044	0.0097
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0072	0.0641	0.1748
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0014	0.0075	0.0165
Echinococcus granulosus	ecdysone induced protein 78C	0.0012	0.0054	0.0054
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0011	0.0044	0.0044
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0381	0.5852
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0012	0.0054	0.0132
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0041	0.0335	0.083
Trypanosoma cruzi	target of rapamycin kinase 3	0.0072	0.0641	0.1748
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0041	0.0335	0.4881
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0014	0.0075	0.0075
Brugia malayi	Steroid receptor seven-up type 2	0.0012	0.0054	0.0132
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0072	0.0641	0.1748
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0011	0.0044	0.0044
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0011	0.0044	0.0109
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0011	0.0044	0.0109
Toxoplasma gondii	FATC domain-containing protein	0.0041	0.0335	0.3506
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0072	0.0641	1
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0091	0.0818	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0044	0.0109
Schistosoma mansoni	peptidase Clp (S14 family)	0.0091	0.0818	0.1805
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0059	0.0515	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0075	0.0185
Brugia malayi	Protein-tyrosine phosphatase	0.0011	0.0044	0.0109
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0014	0.0075	0.0984
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0044	0.0109
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0072	0.0641	1
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	0.0031	0.0242	0.2255
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0031	0.0242	0.2255
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0423	0.404	0.404
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0044	0.0109
Onchocerca volvulus		0.0014	0.0075	0.1415
Onchocerca volvulus		0.0014	0.0075	0.1415
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0011	0.0044	0.0109
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0014	0.0075	0.009
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0014	0.0075	0.0518
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0044	0.0109
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0091	0.0818	0.5
Entamoeba histolytica	hypothetical protein	0.0014	0.0075	0.0518
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0044	0.0109
Entamoeba histolytica	hypothetical protein	0.0014	0.0075	0.0518
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0011	0.0044	0.0109
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0335	0.5133
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0072	0.0641	1
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0014	0.0075	0.0165
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0014	0.0075	0.0075
Brugia malayi	FAT domain containing protein	0.0032	0.0246	0.0608
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0041	0.0335	0.083
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0041	0.0335	0.0335
Schistosoma mansoni	hypothetical protein	0.0014	0.0075	0.0165
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0072	0.0641	0.7619
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0014	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0381	0.0942
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0014	0.0075	0.0984
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0011	0.0044	0.0097
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0011	0.0044	0.0044
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.0381	0.5852
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0072	0.0641	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0335	0.5133
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0011	0.0044	0.0109
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0011	0.0044	0.0044
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0012	0.0054	0.0118
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.002	0.002
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0014	0.0075	0.0185
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0012	0.0054	0.0132
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0011	0.0044	0.0109
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0014	0.0075	0.0984
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0014	0.0075	0.0165
Schistosoma mansoni	cpg binding protein	0.0033	0.0262	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0044	0.0109
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0041	0.0335	0.0853
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0012	0.0054	0.0132
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0335	0.5133
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0072	0.0641	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0072	0.0641	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0072	0.0641	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0054	0.0132
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0012	0.0054	0.0054
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0014	0.0075	0.0984
Brugia malayi	Probable ClpP-like protease	0.0091	0.0818	0.2024
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0044	0.0109
Leishmania major	hypothetical protein, unknown function	0.0014	0.0075	0.0087
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0072	0.0641	1
Echinococcus multilocularis	dnaJ subfamily B	0.0474	0.4531	0.4531
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0011	0.0044	0.0109
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0011	0.0044	0.0044
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0072	0.0641	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0072	0.0641	1
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0014	0.0075	0.009
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0012	0.0054	0.0054
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0014	0.0075	0.0984
Schistosoma mansoni	protein tyrosine phosphatase	0.0011	0.0044	0.0097
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0054	0.0118
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0011	0.0044	0.0097
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0045	0.0381	0.4114
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0014	0.0075	0.0518
Schistosoma mansoni	cpg binding protein	0.0035	0.0281	0.062
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0014	0.0075	0.0075
Brugia malayi	nuclear receptor NHR-88	0.0012	0.0054	0.0132
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.0054	0.0118
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0012	0.0054	0.0132
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0072	0.0641	0.1682
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0011	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0054	0.0132
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0011	0.0044	0.0097
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0011	0.0044	0.0109
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0072	0.0641	0.1682
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0011	0.0044	0.0109
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0014	0.0075	0.0165
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0072	0.0641	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0054	0.0132
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0072	0.0641	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0011	0.0044	0.0109
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0041	0.0335	0.074
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0011	0.0044	0.0044
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0014	0.0075	0.0185
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0072	0.0641	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0044	0.0109
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0011	0.0044	0.0044
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0054	0.0132
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0014	0.0075	0.0075
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0011	0.0044	0.0109
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0091	0.0818	0.5
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0072	0.0641	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0011	0.0044	0.0109
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0014	0.0075	0.009
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0072	0.0641	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0011	0.0044	0.0109
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0011	0.0044	0.0044
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0059	0.0515	0.5929
Schistosoma mansoni	hypothetical protein	0.0032	0.0246	0.0542
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0072	0.0641	0.1587
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0014	0.0075	0.0518
Toxoplasma gondii	hypothetical protein	0.0031	0.0242	0.2255
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0818	0.2024
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0044	0.0109
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0072	0.0641	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0011	0.0044	0.0109
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0011	0.0044	0.0044
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0014	0.0075	0.0984
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0011	0.0044	0.0109
Loa Loa (eye worm)	phosphatidylinositol 3	0.0014	0.0075	0.0185
Echinococcus multilocularis		0.0014	0.0075	0.0075
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0091	0.0818	0.5
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0054	0.0132
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0012	0.0054	0.0118
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0011	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0044	0.0109
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0011	0.0044	0.0109
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0071	0.0624	0.1377
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0044	0.0109
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0011	0.0044	0.0044
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0011	0.0044	0.0044
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0014	0.0075	0.0087
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0423	0.404	0.8917
Loa Loa (eye worm)	histone methyltransferase	0.001	0.004	0.0099
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0011	0.0044	0.0097
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0011	0.0044	0.0044
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.004	0.004
Echinococcus granulosus	cpg binding protein	0.0035	0.0281	0.0281
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0014	0.0075	0.0984
Entamoeba histolytica	hypothetical protein	0.0041	0.0335	0.4881
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.002	0.002
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0011	0.0044	0.0044
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0012	0.0054	0.0132
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0014	0.0075	0.0185
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0012	0.0054	0.0054
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0091	0.0818	0.5
Brugia malayi	Protein-tyrosine phosphatase 1	0.0011	0.0044	0.0109
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0014	0.0075	0.0185
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0054	0.0132
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0072	0.0641	0.0641
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0011	0.0044	0.0097
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0014	0.0075	0.0984
Loa Loa (eye worm)	phosphatidylinositol 3	0.0072	0.0641	0.1587
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0014	0.0075	0.0984
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0012	0.0054	0.0054
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0014	0.0075	0.0518
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0423	0.404	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0011	0.0044	0.0044
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0011	0.0044	0.0044
Echinococcus granulosus	serine protein kinase ATM	0.0041	0.0335	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0044	0.0109
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0012	0.0054	0.0054
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0012	0.0054	0.0054
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0011	0.0044	0.0044
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0011	0.0044	0.0097
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0014	0.0075	0.0984
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0041	0.0335	0.0853
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0014	0.0075	0.0518
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0011	0.0044	0.0109
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0011	0.0044	0.0109
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0014	0.0075	0.0185
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0012	0.0054	0.0132
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0014	0.0075	0.009
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0011	0.0044	0.0044
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0014	0.0075	0.0075
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0011	0.0044	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0044	0.0109
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0011	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0044	0.0109
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0041	0.0335	0.074
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0032	0.0246	0.0246
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0072	0.0641	0.1748
Schistosoma mansoni	retinoic acid receptor RXR	0.0012	0.0054	0.0118
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0054	0.0132
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0091	0.0818	0.0818
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0054	0.0054
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0012	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0044	0.0109
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0011	0.0044	0.0044
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0014	0.0075	0.0518
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0044	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0044	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0044	0.0109
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0014	0.0075	0.0165
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0014	0.0075	0.0518
Giardia lamblia	GTOR	0.0072	0.0641	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0012	0.0054	0.0132
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0072	0.0641	1
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0014	0.0075	0.0518
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0011	0.0044	0.0109
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0011	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0246	0.0608
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0014	0.0075	0.009
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0012	0.0054	0.0118
Schistosoma mansoni	hypothetical protein	0.0474	0.4531	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0012	0.0054	0.0132
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0012	0.0054	0.0132
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0011	0.0044	0.0109
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0072	0.0641	1
Echinococcus multilocularis	cpg binding protein	0.0035	0.0281	0.0281
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0423	0.404	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.0012	0.0054	0.0435
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0011	0.0044	0.0109
Brugia malayi	ecdysteroid receptor	0.0012	0.0054	0.0132
Echinococcus granulosus	dnaJ subfamily B	0.0474	0.4531	0.4531
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0044	0.0109
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0011	0.0044	0.0109
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0011	0.0044	0.0097
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0011	0.0044	0.0109
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0014	0.0075	0.0075
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0011	0.0044	0.0044
Giardia lamblia	Hypothetical protein	0.0014	0.0075	0.0518
Brugia malayi	hypothetical protein	0.0011	0.0044	0.0109
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0014	0.0075	0.0075
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0014	0.0075	0.0075
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0014	0.0075	0.0518
Brugia malayi	nuclear hormone receptor	0.0012	0.0054	0.0132
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0012	0.0054	0.0118
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0072	0.0641	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0012	0.0054	0.0132
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0011	0.0044	0.0044
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0072	0.0641	0.1415
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0014	0.0075	0.0087
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0072	0.0641	1
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0014	0.0075	0.0518
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0201	0.0496
Onchocerca volvulus		0.0033	0.0262	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0014	0.0075	0.0518
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0423	0.404	0.404
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0011	0.0044	0.0109
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0011	0.0044	0.0109
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0072	0.0641	1
Echinococcus granulosus	FTZ F1 alpha	0.0012	0.0054	0.0054
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0014	0.0075	0.0984
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0054	0.0118
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0072	0.0641	1
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0032	0.0246	0.0246
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0072	0.0641	0.0641
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0011	0.0044	0.0044
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0012	0.0054	0.0132
Brugia malayi	hypothetical protein	0.0011	0.0044	0.0109
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0091	0.0818	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0044	0.0109
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0072	0.0641	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0201	0.2985
Loa Loa (eye worm)	steroid hormone receptor	0.0012	0.0054	0.0132
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0041	0.0335	0.4881
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0012	0.0054	0.0118
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0014	0.0075	0.0075
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0014	0.0075	0.0984
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0012	0.0054	0.0132
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0054	0.0054
Brugia malayi	hypothetical protein	0.0011	0.0044	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0054	0.0132
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0014	0.0075	0.0518
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0011	0.0044	0.0044
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0091	0.0818	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0011	0.0044	0.0044
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0014	0.0075	0.0984
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0072	0.0641	1
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0091	0.0818	0.0818
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0014	0.0075	0.009
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0063	0.0551	0.6405
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0014	0.0075	0.0984
Onchocerca volvulus		0.0012	0.0054	0.0435
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0335	0.5133
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0014	0.0075	0.0075
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0027	0.0201	0.0458
Entamoeba histolytica	hypothetical protein	0.0014	0.0075	0.0518
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0091	0.0818	1
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0072	0.0641	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0054	0.0132
Entamoeba histolytica	hypothetical protein	0.0014	0.0075	0.0518
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0072	0.0641	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0335	0.5133
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0012	0.0054	0.0118
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0072	0.0641	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0054	0.0132
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0011	0.0044	0.0109
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0011	0.0044	0.0109
Schistosoma mansoni	nuclear hormone receptor	0.0012	0.0054	0.0118
Echinococcus multilocularis	serine protein kinase ATM	0.0041	0.0335	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0054	0.0132
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.1038	1	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0014	0.0075	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0054	0.0132
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0011	0.0044	0.0109
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0012	0.0054	0.0435
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0011	0.0044	0.0109
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0072	0.0641	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0072	0.0641	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0044	0.0109
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0014	0.0075	0.0165
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0011	0.0044	0.0109
Schistosoma mansoni	protein tyrosine phosphatase	0.0011	0.0044	0.0097
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0011	0.0044	0.0044
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.004	0.004
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0091	0.0818	0.5
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0033	0.0262	0.065
Brugia malayi	CXXC zinc finger family protein	0.0033	0.0262	0.065
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0011	0.0044	0.0044
Brugia malayi	steroid hormone receptor	0.0012	0.0054	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0044	0.0109
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0335	0.5133
Onchocerca volvulus	Bile acid receptor homolog	0.0012	0.0054	0.0435
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0014	0.0075	0.0185
Echinococcus multilocularis	Zinc finger, PHD finger	0.0014	0.0075	0.0075
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0012	0.0054	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0335	0.083
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0011	0.0044	0.0097
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0014	0.0075	0.0518
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0011	0.0044	0.0044
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0072	0.0641	0.1682
Trypanosoma cruzi	hypothetical protein, conserved	0.0363	0.3459	1
Brugia malayi	Protein-tyrosine phosphatase	0.0011	0.0044	0.0109
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0054	0.0132
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0014	0.0075	0.009
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0072	0.0641	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0072	0.0641	1
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0014	0.0075	0.0518
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0011	0.0044	0.0097
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0011	0.0044	0.0044
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0201	0.2985
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0014	0.0075	0.0984
Echinococcus multilocularis	FTZ F1 alpha	0.0012	0.0054	0.0054
Loa Loa (eye worm)	phosphatidylinositol 3	0.0014	0.0075	0.0185
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0091	0.0818	1
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0014	0.0075	0.0075
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0011	0.0044	0.0109
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0011	0.0044	0.0097
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0014	0.0075	0.0185
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.002	0.002
Schistosoma mansoni	protein tyrosine phosphatase	0.0011	0.0044	0.0097
Echinococcus granulosus	peptidase Clp S14 family	0.0059	0.0515	0.0515
Leishmania major	phosphatidylinositol kinase, putative	0.0014	0.0075	0.0087
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0011	0.0044	0.0044
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0072	0.0641	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0072	0.0641	1
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0014	0.0075	0.009
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.002	0.002
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0075	0.0185
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0059	0.0515	1
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0072	0.0641	0.0641
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0011	0.0044	0.0109
Echinococcus multilocularis	ecdysone induced protein 78C	0.0012	0.0054	0.0054
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0072	0.0641	0.1682
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0014	0.0075	0.0518
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0335	0.5133
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0014	0.0075	0.0185
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0014	0.0075	0.0518
Brugia malayi	hypothetical protein	0.0011	0.0044	0.0109
Echinococcus multilocularis		0.0011	0.0044	0.0044
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0011	0.0044	0.0109
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0011	0.0044	0.0044
Leishmania major	hypothetical protein, conserved	0.0377	0.3593	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0011	0.0044	0.0044
Loa Loa (eye worm)	phosphatidylinositol 3	0.0072	0.0641	0.1587
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0072	0.0641	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0044	0.0109
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0072	0.0641	0.0641
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0011	0.0044	0.0044
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0014	0.0075	0.0984
Trichomonas vaginalis	pten, drome, putative	0.0011	0.0044	0.0492
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0014	0.0075	0.0087
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0012	0.0054	0.0054
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0072	0.0641	0.1415
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0091	0.0818	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0014	0.0075	0.0185
Loa Loa (eye worm)	phosphatidylinositol 3	0.0014	0.0075	0.0185
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0072	0.0641	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0011	0.0044	0.0109
Schistosoma mansoni	cpg binding protein	0.0035	0.0281	0.062
Brugia malayi	hypothetical protein	0.0011	0.0044	0.0109
Schistosoma mansoni	coup transcription factor	0.0012	0.0054	0.0118
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0011	0.0044	0.0097
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0335	0.5133
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0014	0.0075	0.0165
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0059	0.0515	0.0515
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0072	0.0641	1
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0031	0.0242	0.2255
Entamoeba histolytica	protein kinase rad3, putative	0.0041	0.0335	0.4881
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0044	0.0109
Echinococcus multilocularis	hypothetical protein	0.0011	0.0044	0.0044
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0014	0.0075	0.009
Brugia malayi	photoreceptor-specific nuclear receptor	0.0012	0.0054	0.0132
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0054	0.0054
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0014	0.0075	0.0087
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0012	0.0054	0.0054
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.002	0.0044
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0011	0.0044	0.0044
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0011	0.0044	0.0109
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0011	0.0044	0.0109
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0041	0.0335	0.0335
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0011	0.0044	0.0097
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0011	0.0044	0.0044
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0014	0.0075	0.0185
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0011	0.0044	0.0109
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0011	0.0044	0.0097
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0072	0.0641	0.1748
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0045	0.0381	0.5637
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0011	0.0044	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0044	0.0109
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0012	0.0054	0.0132
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0014	0.0075	0.009
Schistosoma mansoni	RAR-like nuclear receptor	0.0012	0.0054	0.0118

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 0.31 uM	Inhibition of human recombinant PTP1B	ChEMBL.	17705360
Ki (binding)	= 0.31 uM	Inhibition of human recombinant PTP1B	ChEMBL.	17705360

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 17758007

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 433785