Detailed information for compound 449439

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 517.474 | Formula: C20H38IN8-
  • H donors: 2 H acceptors: 2 LogP: 5.08 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 2
  • SMILES: CN(/C(=N/C#N)/NCCCCCCCCCCCCN/C(=N/C#N)/N(C)C)C.[I-]
  • InChi: 1S/C20H38N8.HI/c1-27(2)19(25-17-21)23-15-13-11-9-7-5-6-8-10-12-14-16-24-20(26-18-22)28(3)4;/h5-16H2,1-4H3,(H,23,25)(H,24,26);1H/p-1
  • InChiKey: NCDAQYVJZPODOV-UHFFFAOYSA-M  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0041 0.0364 0.5587
Trichomonas vaginalis sugar transporter, putative 0.003 0.0247 0.0956
Loa Loa (eye worm) hypothetical protein 0.003 0.0247 0.0562
Plasmodium falciparum threonine--tRNA ligase 0.0012 0.0047 0.0046
Schistosoma mansoni sugar transporter 0.003 0.0247 0.0562
Toxoplasma gondii hypothetical protein 0.0009 0.001 0.0014
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0131 0.013
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.003 0.016
Plasmodium falciparum calcium-dependent protein kinase 4 0.0066 0.0641 0.064
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0247 0.0956
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.001 0.0024
Loa Loa (eye worm) hypothetical protein 0.0042 0.0378 0.0859
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.003 0.0069
Echinococcus granulosus glycyl tRNA synthetase 0.0012 0.0047 0.0107
Schistosoma mansoni smad1 5 8 and 0.0018 0.0107 0.0244
Echinococcus granulosus solute carrier family 22 0.003 0.0247 0.0562
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0641 0.1456
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.003 0.0069
Loa Loa (eye worm) transcription factor SMAD2 0.0258 0.2762 0.6272
Schistosoma mansoni inositol transporter 0.0045 0.0409 0.0928
Mycobacterium tuberculosis Conserved protein 0.0042 0.0378 0.1216
Loa Loa (eye worm) hypothetical protein 0.0011 0.003 0.0069
Schistosoma mansoni thyroid hormone receptor 0.0011 0.003 0.0069
Trichomonas vaginalis sugar transporter, putative 0.003 0.0247 0.0956
Plasmodium falciparum calcium-dependent protein kinase 1 0.0066 0.0641 0.064
Onchocerca volvulus 0.0042 0.0378 0.2006
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.0378 0.1216
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.001 0.0024
Loa Loa (eye worm) nuclear factor I 0.001 0.0021 0.0047
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0045 0.0409 0.044
Trichomonas vaginalis sugar transporter, putative 0.003 0.0247 0.0956
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0048 0.0444 0.6932
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0247 0.0562
Trichomonas vaginalis glucose transporter, putative 0.0067 0.065 0.274
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.003 0.0247 0.303
Schistosoma mansoni hypothetical protein 0.0215 0.229 0.52
Echinococcus granulosus calcium dependent protein kinase 0.0062 0.0596 0.1353
Echinococcus granulosus solute carrier family 22 0.003 0.0247 0.0562
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.0504 0.0542
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.001 0.0024
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.003 0.0032
Brugia malayi hypothetical protein 0.003 0.0247 0.0562
Trypanosoma cruzi hexose transporter, putative 0.0067 0.065 0.868
Loa Loa (eye worm) hypothetical protein 0.0065 0.0626 0.1422
Trichomonas vaginalis sugar transporter, putative 0.003 0.0247 0.0956
Mycobacterium ulcerans lipase LipD 0.0042 0.0378 0.8415
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0075 0.0744 1
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0247 0.0956
Loa Loa (eye worm) hypothetical protein 0.003 0.0247 0.0562
Trypanosoma brucei glucose transporter, putative 0.0067 0.065 0.868
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0215 0.229 0.2464
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0131 0.1412
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0066 0.0641 0.0597
Trichomonas vaginalis sugar transporter, putative 0.003 0.0247 0.0956
Trypanosoma brucei sugar transporter, putative 0.003 0.0247 0.303
Echinococcus granulosus sodium:myo inositol cotransporter 0.0045 0.0409 0.0928
Echinococcus multilocularis solute carrier family 22 0.003 0.0247 0.0266
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0045 0.0409 0.0615
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.003 0.0069
Trypanosoma brucei THT1 - hexose transporter, putative 0.0067 0.065 0.868
Trichomonas vaginalis sugar transporter, putative 0.003 0.0247 0.0956
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.003 0.0069
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.003 0.0247 0.0757
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0378 0.0859
Schistosoma mansoni dishevelled 0.0009 0.001 0.0024
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.003 0.0069
Loa Loa (eye worm) hypothetical protein 0.003 0.0247 0.0562
Trypanosoma brucei glucose transporter, putative 0.0067 0.065 0.868
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0378 0.0859
Trichomonas vaginalis sugar transporter, putative 0.003 0.0247 0.0956
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.003 0.0069
Brugia malayi MH1 domain containing protein 0.001 0.0021 0.0047
Echinococcus granulosus Sugar transporter ERD6 protein 0.003 0.0247 0.0562
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.003 0.0069
Onchocerca volvulus 0.003 0.0247 0.1311
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0075 0.0744 1
Schistosoma mansoni high-affinity choline transporter 0.0407 0.4404 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0247 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0247 0.0956
Schistosoma mansoni glycyl-tRNA synthetase 0.0012 0.0047 0.0107
Loa Loa (eye worm) hypothetical protein 0.0042 0.0378 0.0859
Loa Loa (eye worm) hypothetical protein 0.003 0.0247 0.0562
Loa Loa (eye worm) hypothetical protein 0.0065 0.0626 0.1422
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0075 0.0744 0.1121
Schistosoma mansoni sodium/solute symporter 0.0045 0.0409 0.0928
Toxoplasma gondii sugar transporter ST2 0.003 0.0247 0.0371
Onchocerca volvulus 0.003 0.0247 0.1311
Onchocerca volvulus Putative transporter 0.003 0.0247 0.1311
Echinococcus multilocularis solute carrier family 22 0.003 0.0247 0.0266
Echinococcus granulosus solute carrier family 22 0.003 0.0247 0.0562
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.0641 0.069
Plasmodium vivax hexose transporter 0.0215 0.229 0.2253
Trypanosoma brucei glucose transporter, putative 0.0067 0.065 0.868
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.003 0.0247 0.5239
Trichomonas vaginalis sugar transporter, putative 0.003 0.0247 0.0956
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0048 0.0444 0.5783
Leishmania major hypothetical protein, conserved 0.0011 0.0031 0.0405
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0027 0.0206 0.0468
Schistosoma mansoni glucose transport protein 0.0215 0.229 0.52
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.003 0.0247 0.5239
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.003 0.0069
Plasmodium falciparum hexose transporter 0.0215 0.229 0.2289
Leishmania major glucose transporter/membrane transporter D2, putative 0.0067 0.065 0.8734
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0065 0.0626 0.9752
Brugia malayi nuclear receptor NHR-88 0.0011 0.003 0.0069
Plasmodium falciparum calcium-dependent protein kinase 5 0.0066 0.0641 0.064
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0066 0.0641 0.1456
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0131 0.2412
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.003 0.0069
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0075 0.0744 1
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.065 0.274
Plasmodium vivax proline--tRNA ligase, putative 0.0075 0.0744 0.0701
Loa Loa (eye worm) hypothetical protein 0.0407 0.4404 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.085 0.9295 1
Brugia malayi beta-lactamase family protein 0.0042 0.0378 0.0859
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.003 0.0247 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0378 0.1536
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0247 0.0562
Echinococcus granulosus General substrate transporter 0.0185 0.1956 0.4441
Brugia malayi major facilitator superfamily protein 0.003 0.0247 0.0562
Trichomonas vaginalis sugar transporter, putative 0.003 0.0247 0.0956
Schistosoma mansoni lysyl-tRNA synthetase 0.0048 0.0444 0.1008
Toxoplasma gondii sugar transporter ST1 0.003 0.0247 0.0371
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0008 0.0001 0.0001
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.003 0.0069
Loa Loa (eye worm) hypothetical protein 0.0011 0.003 0.0069
Plasmodium falciparum calcium-dependent protein kinase 3 0.0066 0.0641 0.064
Leishmania major glucose transporter, lmgt3 0.0067 0.065 0.8734
Plasmodium falciparum lysine--tRNA ligase 0.0048 0.0444 0.0442
Brugia malayi ecdysteroid receptor 0.0011 0.003 0.0069
Trichomonas vaginalis sugar transporter, putative 0.0067 0.065 0.274
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0378 0.1536
Giardia lamblia Sugar-proton symporter 0.003 0.0247 0.346
Schistosoma mansoni coup transcription factor 0.0011 0.003 0.0069
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0504 0.1145
Echinococcus granulosus FTZ F1 alpha 0.0011 0.003 0.0069
Brugia malayi hypothetical protein 0.0009 0.001 0.0024
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0012 0.0047 0.0107
Trypanosoma cruzi sugar transporter, putative 0.003 0.0247 0.303
Toxoplasma gondii lysine-tRNA ligase 0.0048 0.0444 0.0668
Onchocerca volvulus 0.0009 0.001 0.0055
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0378 0.0333
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.001 0.0011
Leishmania major glucose transporter, lmgt2 0.0067 0.065 0.8734
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0012 0.0047 0.0377
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.003 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.065 0.274
Trichomonas vaginalis sugar transporter, putative 0.003 0.0247 0.0956
Schistosoma mansoni protein kinase 0.0066 0.0641 0.1456
Onchocerca volvulus 0.0011 0.003 0.016
Loa Loa (eye worm) beta-lactamase 0.0042 0.0378 0.0859
Plasmodium vivax calcium-dependent protein kinase, putative 0.0066 0.0641 0.0597
Trichomonas vaginalis myo-inositol transporter, putative 0.003 0.0247 0.0956
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0215 0.229 0.2464
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0485 0.1102
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0215 0.229 0.52
Schistosoma mansoni thyroid hormone receptor 0.0011 0.003 0.0069
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0066 0.0641 0.1456
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0066 0.0641 0.855
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0012 0.0047 0.0069
Trichomonas vaginalis sugar transporter, putative 0.003 0.0247 0.0956
Echinococcus granulosus smad 0.0018 0.0107 0.0244
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0065 0.0626 1
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0066 0.0641 0.0966
Schistosoma mansoni dishevelled 0.0009 0.001 0.0024
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.003 0.0032
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0012 0.0047 0.0055
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0504 0.1145
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0378 0.4866
Echinococcus multilocularis expressed conserved protein 0.0008 0.0001 0.0001
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0012 0.0047 0.0377
Trypanosoma brucei THT1 - hexose transporter, putative 0.0067 0.065 0.868
Trichomonas vaginalis sugar transporter, putative 0.003 0.0247 0.0956
Echinococcus granulosus cGMP dependent protein kinase 0.0008 0.0001 0.0003
Trichomonas vaginalis sugar transport protein, putative 0.003 0.0247 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0067 0.065 0.274
Onchocerca volvulus 0.003 0.0247 0.1311
Mycobacterium tuberculosis Conserved protein 0.0042 0.0378 0.1216
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0065 0.0626 0.1422
Schistosoma mansoni sugar transporter 0.003 0.0247 0.0562
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0131 0.1395
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.003 0.0069
Echinococcus multilocularis tumor protein p63 0.0354 0.3822 0.4112
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0131 0.0297
Loa Loa (eye worm) hypothetical protein 0.003 0.0247 0.0562
Onchocerca volvulus 0.0042 0.0378 0.2006
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0107 0.0244
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.003 0.0069
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.003 0.0069
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0066 0.0641 0.1456
Trichomonas vaginalis sugar transporter, putative 0.003 0.0247 0.0956
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.003 0.0069
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0378 0.4866
Trichomonas vaginalis conserved hypothetical protein 0.0215 0.229 1
Leishmania major hypothetical protein, conserved 0.0042 0.0378 0.5075
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.003 0.0069
Trichomonas vaginalis sugar transporter, putative 0.0067 0.065 0.274
Brugia malayi MH1 domain containing protein 0.0018 0.0107 0.0244
Onchocerca volvulus 0.003 0.0247 0.1311
Loa Loa (eye worm) sugar transporter 0.003 0.0247 0.0562
Loa Loa (eye worm) hypothetical protein 0.0045 0.0409 0.0928
Toxoplasma gondii glycyl-tRNA synthetase 0.0012 0.0047 0.0069
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0131 0.0348
Trypanosoma brucei glucose transporter 2A 0.0067 0.065 0.868
Trichomonas vaginalis sugar transporter, putative 0.003 0.0247 0.0956
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.0641 0.069
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.0641 0.069
Mycobacterium ulcerans integral membrane transport protein 0.003 0.0247 0.5239
Schistosoma mansoni dep domain containing protein 0.0009 0.001 0.0024
Trichomonas vaginalis sugar transporter, putative 0.003 0.0247 0.0956
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0131 0.4184
Schistosoma mansoni smad1 5 8 and 0.0018 0.0107 0.0244
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0378 0.0859
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0045 0.0409 0.044
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0316 0.3994
Brugia malayi GH02984p 0.0407 0.4404 1
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.001 0.0024
Schistosoma mansoni ap endonuclease 0.002 0.0131 0.0297
Brugia malayi steroid hormone receptor 0.0011 0.003 0.0069
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0048 0.0444 1
Brugia malayi MH2 domain containing protein 0.0258 0.2762 0.6272
Trichomonas vaginalis sugar transporter, putative 0.003 0.0247 0.0956
Loa Loa (eye worm) hypothetical protein 0.0011 0.003 0.0069
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.003 0.016
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.0378 0.1216
Echinococcus multilocularis solute carrier family 22 0.003 0.0247 0.0266
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0179 0.1887 1
Schistosoma mansoni protein kinase 0.0066 0.0641 0.1456
Echinococcus multilocularis Sugar transporter ERD6 protein 0.003 0.0247 0.0266
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.001 0.0024
Toxoplasma gondii ABC1 family protein 0.0042 0.0378 0.0569
Trichomonas vaginalis sugar transporter, putative 0.003 0.0247 0.0956
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.001 0.0024
Schistosoma mansoni Smad4 0.0018 0.0107 0.0244
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0066 0.0641 0.0597
Echinococcus granulosus solute carrier family 22 0.003 0.0247 0.0562
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.0504 0.1145
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0131 0.1395
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0054 0.0504 0.1145
Loa Loa (eye worm) hypothetical protein 0.0009 0.001 0.0024
Trichomonas vaginalis sugar transporter, putative 0.003 0.0247 0.0956
Loa Loa (eye worm) hypothetical protein 0.0011 0.003 0.0069
Schistosoma mansoni glucose transport protein 0.0215 0.229 0.52
Loa Loa (eye worm) hypothetical protein 0.003 0.0247 0.0562
Trypanosoma brucei glucose transporter, putative 0.0067 0.065 0.868
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0215 0.229 0.2464
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0008 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0042 0.0378 0.0859
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0215 0.229 0.52
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0247 0.0562
Echinococcus multilocularis lysyl tRNA synthetase 0.0048 0.0444 0.0477
Brugia malayi hypothetical protein 0.0009 0.001 0.0024
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0107
Echinococcus multilocularis calcium dependent protein kinase 0.0062 0.0596 0.0641
Chlamydia trachomatis lysine--tRNA ligase 0.0048 0.0444 1
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.003 0.0032
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.0378 0.1216
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0131 0.0084
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0215 0.229 0.2464
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0048 0.0444 1
Schistosoma mansoni sugar transporter 0.003 0.0247 0.0562
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.003 0.0069
Loa Loa (eye worm) hypothetical protein 0.0009 0.001 0.0024
Toxoplasma gondii sugar transporter ST3 0.003 0.0247 0.0371
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.003 0.0069
Echinococcus granulosus cGMP dependent protein kinase 1 0.0008 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.003 0.0247 0.0562
Echinococcus granulosus sodium:glucose cotransporter 2 0.0045 0.0409 0.0928
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0378 0.1536
Trichomonas vaginalis sugar transporter, putative 0.003 0.0247 0.0956
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.003 0.0069
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.001 0.0055
Brugia malayi N-terminal motif family protein 0.0179 0.1887 0.4284
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.003 0.0069
Toxoplasma gondii protein kinase, putative 0.0609 0.6628 1
Entamoeba histolytica protein kinase, putative 0.0066 0.0641 1
Onchocerca volvulus 0.0052 0.0485 0.2573
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.003 0.0069
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0065 0.0626 0.1422
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0054 0.0504 0.1145
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.003 0.0069
Echinococcus multilocularis solute carrier family 22 0.003 0.0247 0.0266
Schistosoma mansoni smad 0.0018 0.0107 0.0244
Loa Loa (eye worm) Smad1 0.0018 0.0107 0.0244
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0012 0.0047 0.0107
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.0641 0.2699
Loa Loa (eye worm) hypothetical protein 0.001 0.0021 0.0047
Giardia lamblia Prolyl-tRNA synthetase 0.0065 0.0626 1
Plasmodium vivax lysine--tRNA ligase, putative 0.0048 0.0444 0.0399
Schistosoma mansoni serine/threonine protein kinase 0.0008 0.0001 0.0003
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0066 0.0641 0.1456
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.001 0.0011
Trichomonas vaginalis glucose transporter, putative 0.003 0.0247 0.0956
Entamoeba histolytica hypothetical protein 0.0048 0.0444 0.6679
Trichomonas vaginalis sugar transporter, putative 0.003 0.0247 0.0956
Leishmania major lysyl-tRNA synthetase, putative 0.0048 0.0444 0.5954
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0378 0.1536
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.003 0.0069
Echinococcus granulosus Threonyl tRNA synthetase C 0.0012 0.0047 0.0107
Echinococcus granulosus synaptic vesicle 2 protein 0.003 0.0247 0.0562
Plasmodium falciparum calcium-dependent protein kinase 2 0.0066 0.0641 0.064
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.001 0.0011
Leishmania major hypothetical protein, conserved 0.0011 0.0031 0.0405
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.003 0.0069
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0012 0.0047 0.0069
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.003 0.0069
Echinococcus multilocularis smad 0.0018 0.0107 0.0115
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0075 0.0744 1
Brugia malayi major facilitator superfamily protein 0.003 0.0247 0.0562
Brugia malayi glycyl-tRNA synthetase 0.0012 0.0047 0.0107
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0041 0.0364 0.1165
Trichomonas vaginalis sugar transporter, putative 0.003 0.0247 0.0956
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.003 0.0069
Trichomonas vaginalis sugar transporter, putative 0.003 0.0247 0.0956
Loa Loa (eye worm) hypothetical protein 0.003 0.0247 0.0562
Schistosoma mansoni ap endonuclease 0.002 0.0131 0.0297
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.0378 0.1216
Leishmania major glucose transporter, lmgt1 0.0067 0.065 0.8734
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0107 0.0244
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.003 0.0069
Trichomonas vaginalis sugar transporter, putative 0.003 0.0247 0.0956
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.003 0.0069
Onchocerca volvulus 0.0042 0.0378 0.2006
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0065 0.0626 0.2634
Trypanosoma brucei glucose transporter, putative 0.0067 0.065 0.868
Onchocerca volvulus 0.003 0.0247 0.1311
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0065 0.0626 0.1422
Trichomonas vaginalis esterase, putative 0.0042 0.0378 0.1536
Plasmodium falciparum proline--tRNA ligase 0.0075 0.0744 0.0743
Brugia malayi lysyl-tRNA synthetase 0.0048 0.0444 0.1008
Loa Loa (eye worm) hypothetical protein 0.0053 0.0493 0.1118
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.003 0.0069
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0378 0.0407
Trichomonas vaginalis sugar transporter, putative 0.003 0.0247 0.0956
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.003 0.0069
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.0504 0.1145
Onchocerca volvulus 0.003 0.0247 0.1311
Trichomonas vaginalis sugar transporter, putative 0.003 0.0247 0.0956
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.0378 0.1216
Plasmodium vivax sugar transporter, putative 0.003 0.0247 0.0201
Echinococcus multilocularis glycyl tRNA synthetase 0.0012 0.0047 0.0051
Brugia malayi nuclear hormone receptor 0.0011 0.003 0.0069
Loa Loa (eye worm) hypothetical protein 0.0009 0.001 0.0024
Loa Loa (eye worm) hypothetical protein 0.003 0.0247 0.0562
Loa Loa (eye worm) hypothetical protein 0.0066 0.0641 0.1456
Brugia malayi Egg laying defective protein 4 0.0008 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.003 0.0247 0.0562
Loa Loa (eye worm) hypothetical protein 0.0042 0.0378 0.0859
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0012 0.0047 0.0051
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.003 0.0247 0.0562
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0131 0.044
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0107 0.0115
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0065 0.0626 0.1422
Entamoeba histolytica protein kinase, putative 0.0066 0.0641 1
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0247 0.0956
Loa Loa (eye worm) sugar transporter 0.0215 0.229 0.52
Toxoplasma gondii facilitative glucose transporter GT1 0.0215 0.229 0.3454
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0066 0.0641 0.0966
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0012 0.0047 0.0107
Echinococcus multilocularis Smad4 0.0018 0.0107 0.0115
Brugia malayi DIX domain containing protein 0.0009 0.001 0.0024
Schistosoma mansoni smad1 5 8 and 0.0018 0.0107 0.0244
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0131 0.71
Mycobacterium ulcerans beta-lactamase 0.0042 0.0378 0.8415
Loa Loa (eye worm) hypothetical protein 0.0011 0.003 0.0069
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.0378 0.1216
Brugia malayi hypothetical protein 0.003 0.0247 0.0562
Onchocerca volvulus 0.003 0.0247 0.1311
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.001 0.0024
Leishmania major protein kinase, putative 0.0066 0.0641 0.8608
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0066 0.0641 0.0597
Schistosoma mansoni regulator of G protein signaling 0.0009 0.001 0.0024
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0066 0.0641 0.1456
Loa Loa (eye worm) hypothetical protein 0.003 0.0247 0.0562
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0012 0.0047 0.0107
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.003 0.016
Mycobacterium leprae Probable lipase LipE 0.0042 0.0378 0.5833
Loa Loa (eye worm) hypothetical protein 0.003 0.0247 0.0562
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.003 0.0069
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0215 0.229 0.52
Echinococcus multilocularis high affinity choline transporter 1 0.0407 0.4404 0.4738
Loa Loa (eye worm) hypothetical protein 0.0179 0.1887 0.4284
Trypanosoma brucei glucose transporter 1E 0.0067 0.065 0.868
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0247 0.0562
Giardia lamblia Hexose transporter 0.003 0.0247 0.346
Trichomonas vaginalis sugar transporter, putative 0.003 0.0247 0.0956
Trichomonas vaginalis sugar transporter, putative 0.003 0.0247 0.0956
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0131 0.0297
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0215 0.229 0.52
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.003 0.0032
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.0378 0.8415
Schistosoma mansoni nuclear hormone receptor 0.0011 0.003 0.0069
Brugia malayi Sugar transporter family protein 0.003 0.0247 0.0562
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.003 0.0069
Plasmodium falciparum mitogen-activated protein kinase 2 0.0348 0.3754 0.3753
Onchocerca volvulus 0.003 0.0247 0.1311
Trichomonas vaginalis sugar transporter, putative 0.003 0.0247 0.0956
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0107 0.0244
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0107 0.0244
Echinococcus granulosus Smad4 0.0018 0.0107 0.0244
Onchocerca volvulus 0.003 0.0247 0.1311
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.001 0.0024
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0066 0.0641 0.1456
Trypanosoma brucei glucose transporter, putative 0.0067 0.065 0.868
Schistosoma mansoni serine/threonine protein kinase 0.0008 0.0001 0.0003
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0107 0.0244
Brugia malayi Smad1 0.0018 0.0107 0.0244
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0048 0.0444 0.5783
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0269 0.2885 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0065 0.0626 0.1422
Onchocerca volvulus 0.003 0.0247 0.1311
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0012 0.0047 0.0262
Loa Loa (eye worm) hypothetical protein 0.0048 0.0444 0.1008
Trichomonas vaginalis sugar transporter, putative 0.003 0.0247 0.0956
Onchocerca volvulus 0.003 0.0247 0.1311
Schistosoma mansoni serine/threonine protein kinase 0.0008 0.0001 0.0003
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0348 0.3754 0.3724
Trypanosoma cruzi hexose transporter, putative 0.0067 0.065 0.868
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.003 0.0247 0.0246
Echinococcus granulosus solute carrier family 5 0.0045 0.0409 0.0928
Loa Loa (eye worm) hypothetical protein 0.0042 0.0378 0.0859
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0131 0.044
Mycobacterium tuberculosis Conserved protein 0.0042 0.0378 0.1216
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.003 0.0032
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0012 0.0047 0.0218
Leishmania major threonyl-tRNA synthetase, putative 0.0012 0.0047 0.0615
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0066 0.0641 0.0966
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0378 0.0859
Brugia malayi Cam kinase protein 1 0.0066 0.0641 0.1456
Trichomonas vaginalis sugar transporter, putative 0.003 0.0247 0.0956
Loa Loa (eye worm) hypothetical protein 0.0042 0.0378 0.0859
Trypanosoma cruzi hexose transporter, putative 0.0067 0.065 0.868
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0045 0.0409 0.0928
Loa Loa (eye worm) hypothetical protein 0.0011 0.003 0.0069
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0041 0.0364 0.1165
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0075 0.0744 1
Brugia malayi Sodium:solute symporter family protein 0.0045 0.0409 0.0928
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.0378 0.8415
Echinococcus granulosus lysyl tRNA synthetase 0.0048 0.0444 0.1008
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0378 0.1536
Toxoplasma gondii exonuclease III APE 0.002 0.0131 0.0196
Trypanosoma cruzi hexose transporter, putative 0.003 0.0247 0.303
Brugia malayi hypothetical protein 0.003 0.0247 0.0562
Schistosoma mansoni lysyl-tRNA synthetase 0.0048 0.0444 0.1008
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.003 0.0069
Brugia malayi MH2 domain containing protein 0.0018 0.0107 0.0244
Onchocerca volvulus 0.003 0.0247 0.1311
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0247 0.0956
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.003 0.0069
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.003 0.0247 0.0757
Onchocerca volvulus 0.003 0.0247 0.1311
Mycobacterium ulcerans sugar transporter 0.003 0.0247 0.5239
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.0504 0.0542
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.003 0.0069
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0348 0.3754 0.5662
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0047 0.0218
Trichomonas vaginalis sugar transporter, putative 0.003 0.0247 0.0956
Trichomonas vaginalis sugar transporter, putative 0.003 0.0247 0.0956
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.003 0.0069
Plasmodium vivax CDK-related protein kinase 6, putative 0.0914 1 1
Mycobacterium ulcerans hypothetical protein 0.0042 0.0378 0.8415
Brugia malayi MH1 domain containing protein 0.0018 0.0107 0.0244
Brugia malayi Sugar transporter family protein 0.0215 0.229 0.52
Mycobacterium leprae conserved hypothetical protein 0.0042 0.0378 0.5833
Schistosoma mansoni protein kinase 0.0066 0.0641 0.1456
Schistosoma mansoni sugar transporter 0.003 0.0247 0.0562
Onchocerca volvulus 0.003 0.0247 0.1311
Echinococcus multilocularis synaptic vesicle 2 protein 0.003 0.0247 0.0266
Loa Loa (eye worm) MH2 domain-containing protein 0.0258 0.2762 0.6272
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0378 0.0859
Brugia malayi MH1 domain containing protein 0.001 0.0021 0.0047
Onchocerca volvulus 0.003 0.0247 0.1311
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.001 0.0024
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0378 0.4866
Chlamydia trachomatis proline--tRNA ligase 0.0023 0.0165 0.2978
Trichomonas vaginalis sugar transporter, putative 0.003 0.0247 0.0956
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.003 0.0032
Schistosoma mansoni inositol transporter 0.0045 0.0409 0.0928
Toxoplasma gondii transporter, major facilitator family protein 0.003 0.0247 0.0371
Giardia lamblia Lysyl-tRNA synthetase 0.0048 0.0444 0.6849
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.003 0.0069
Loa Loa (eye worm) hypothetical protein 0.0011 0.003 0.0069
Loa Loa (eye worm) hypothetical protein 0.003 0.0247 0.0562
Echinococcus granulosus cGMP dependent protein kinase 1 0.0008 0.0001 0.0003
Treponema pallidum prolyl-tRNA synthetase 0.0023 0.0165 1
Trypanosoma cruzi hexose transporter 0.0067 0.065 0.868
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.003 0.0032
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0247 0.0562
Loa Loa (eye worm) hypothetical protein 0.0011 0.003 0.0069
Trichomonas vaginalis sugar transporter, putative 0.003 0.0247 0.0956
Onchocerca volvulus 0.0045 0.0409 0.2165
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.003 0.0069
Trypanosoma brucei glucose transporter, putative 0.0067 0.065 0.868
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0131 0.1395
Loa Loa (eye worm) AGC/PKG protein kinase 0.0008 0.0001 0.0003
Leishmania major myo-inositol/proton symporter (MIT) 0.003 0.0247 0.3312
Loa Loa (eye worm) hypothetical protein 0.0052 0.0485 0.1102
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.0378 0.1216
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.001 0.0024
Trichomonas vaginalis glucose transporter, putative 0.0067 0.065 0.274
Plasmodium falciparum protein kinase 7 0.0609 0.6628 0.6627
Echinococcus multilocularis solute carrier family 5 0.0045 0.0409 0.044
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.003 0.0069
Echinococcus granulosus sodium:glucose cotransporter 0.0045 0.0409 0.0928
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0131 0.0297
Schistosoma mansoni glucose transport protein 0.0215 0.229 0.52
Loa Loa (eye worm) hypothetical protein 0.003 0.0247 0.0562
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0023 0.0165 0.3243
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.003 0.0032
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0065 0.0626 0.0674
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0012 0.0047 0.0218
Echinococcus multilocularis General substrate transporter 0.0185 0.1956 0.2104
Trypanosoma brucei THT1 - hexose transporter, putative 0.0067 0.065 0.868
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0042 0.0378 0.1536
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0066 0.0641 0.1456
Echinococcus granulosus high affinity choline transporter 1 0.0407 0.4404 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0247 0.0562
Echinococcus granulosus tumor protein p63 0.0354 0.3822 0.868
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0045 0.0409 0.044
Brugia malayi MH2 domain containing protein 0.0018 0.0107 0.0244
Brugia malayi beta-lactamase family protein 0.0042 0.0378 0.0859
Onchocerca volvulus 0.003 0.0247 0.1311
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0504 0.1145
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0047 0.0218
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.001 0.0024
Leishmania major hypothetical protein, conserved 0.003 0.0247 0.3312
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0131 0.1448
Brugia malayi beta-lactamase 0.0042 0.0378 0.0859
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.001 0.0011
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0131 0.0141
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0131 0.1743
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.001 0.0011
Trypanosoma cruzi glucose transporter, putative 0.003 0.0247 0.303
Trypanosoma brucei glucose transporter, putative 0.0067 0.065 0.868
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.003 0.0032
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0107 0.0115
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.001 0.0024
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.0011 0.0031 0.0045
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0048 0.0444 0.1826
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.003 0.0069
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.003 0.0069
Schistosoma mansoni glucose transporter 0.003 0.0247 0.0562
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.0641 0.069
Brugia malayi Sugar transporter family protein 0.003 0.0247 0.0562

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 8500 nM Antimalarial activity against Plasmodium falciparum Nigerian in human erythrocytes after 48 hrs ChEMBL. 18004799
pKa 0 Dissociation constant, pKa of the compound by potentiometric titration ChEMBL. 18004799

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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