TDR Targets

Basic information

Technical information

TDR Targets ID: 501609
Name: 6-[(3,4-dichlorophenyl)methylamino]-9-(3-hydr oxypropyl)purine-2-carbonitrile
MW: 377.228 | Formula: C16H14Cl2N6O
H donors: 2 H acceptors: 5 LogP: 2.78 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: OCCCn1cnc2c1nc(C#N)nc2NCc1ccc(c(c1)Cl)Cl
InChi: 1S/C16H14Cl2N6O/c17-11-3-2-10(6-12(11)18)8-20-15-14-16(23-13(7-19)22-15)24(9-21-14)4-1-5-25/h2-3,6,9,25H,1,4-5,8H2,(H,20,22,23)
InChiKey: BDSGZPUKZJAYIB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

6-[(3,4-dichlorophenyl)methylamino]-9-(3-hydroxypropyl)-2-purinecarbonitrile
6-[(3,4-dichlorobenzyl)amino]-9-(3-hydroxypropyl)purine-2-carbonitrile

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative		References
Homo sapiens	cathepsin B	Starlite/ChEMBL	References
Homo sapiens	cathepsin L	Starlite/ChEMBL	References
Trypanosoma brucei	cysteine peptidase C (CPC)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	cysteine proteinase falcipain 2b	cysteine peptidase C (CPC)	340 aa	321 aa	26.5 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin L	333 aa	359 aa	30.1 %
Plasmodium falciparum	dipeptidyl aminopeptidase 1	cathepsin B	339 aa	368 aa	26.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.004	0.004
Echinococcus granulosus	dnaJ subfamily B	0.0473	0.5901	0.5901
Brugia malayi	Steroid receptor seven-up type 2	0.0011	0.0072	0.0172
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0066	0.0066
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0011	0.0072	0.0072
Entamoeba histolytica	cysteine proteinase 1, putative	0.0034	0.0362	0.4054
Leishmania major	cathepsin L-like protease	0.0047	0.0527	0.1557
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0072	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0072	0.0172
Onchocerca volvulus		0.0056	0.0639	1
Brugia malayi	cathepsin L precursor	0.0025	0.025	0.06
Trypanosoma cruzi	major cysteine proteinase, putative	0.0025	0.025	0.049
Onchocerca volvulus	Cathepsin L homolog	0.0025	0.025	0.3906
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0011	0.0072	0.0172
Loa Loa (eye worm)	cytochrome P450 family protein	0.0014	0.0115	0.0277
Echinococcus multilocularis	cathepsin L	0.0025	0.025	0.025
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0008	0.0018
Brugia malayi	fibroinase precursor	0.0025	0.025	0.06
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0011	0.0072	0.0172
Leishmania major	cathepsin L-like protease	0.0047	0.0527	0.1557
Plasmodium vivax	vivapain-2	0.0047	0.0527	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0047	0.0527	0.1164
Onchocerca volvulus		0.0025	0.025	0.3906
Echinococcus granulosus	cathepsin l1	0.0047	0.0527	0.0527
Entamoeba histolytica	cysteine proteinase, putative	0.0038	0.0415	0.5946
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0011	0.0072	0.0072
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0072	0.0172
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0011	0.0072	0.0172
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0047	0.0527	0.1266
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0072	0.0172
Plasmodium vivax	unspecified product	0.0025	0.025	0.4207
Loa Loa (eye worm)	hypothetical protein	0.0025	0.025	0.06
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0072	0.0172
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0011	0.0072	0.0072
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0034	0.0362	0.1214
Brugia malayi	Cathepsin L-like precursor	0.0009	0.0048	0.0116
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0335	0.4162	0.4162
Brugia malayi	cathepsin L-like precursor	0.0038	0.0415	0.0996
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0025	0.025	0.4207
Echinococcus granulosus	cathepsin l1	0.0038	0.0415	0.0415
Trypanosoma cruzi	cysteine peptidase, putative	0.0047	0.0527	0.1164
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0527	0.1818
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0072	0.0172
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0011	0.0072	0.0072
Echinococcus granulosus	cysteine protease	0.0034	0.0362	0.0362
Entamoeba histolytica	cysteine protease, putative	0.0034	0.0362	0.4054
Echinococcus granulosus	cathepsin L cysteine protease	0.0034	0.0362	0.0362
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0047	0.0527	0.0527
Trypanosoma cruzi	cysteine proteinase, putative	0.0034	0.0362	0.0763
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0006	0.0008	0.0018
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0034	0.0362	0.0933
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0025	0.025	0.06
Trypanosoma cruzi	cytochrome P450, putative	0.0014	0.0115	0.0163
Entamoeba histolytica	cysteine proteinase, putative	0.0034	0.0362	0.4054
Schistosoma mansoni	cathepsin F (C01 family)	0.0038	0.0415	0.0415
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0006	0.0008	0.0008
Schistosoma mansoni	RAR-like nuclear receptor	0.0011	0.0072	0.0072
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0527	0.1557
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.004	0.004
Loa Loa (eye worm)	hypothetical protein	0.0025	0.025	0.06
Schistosoma mansoni	cathepsin F (C01 family)	0.0047	0.0527	0.0527
Plasmodium vivax	serine-repeat antigen (SERA)	0.0025	0.025	0.4207
Giardia lamblia	Cathepsin B precursor	0.0224	0.276	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0014	0.0115	0.0277
Loa Loa (eye worm)	ctsf protein	0.0047	0.0527	0.1266
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0335	0.4162	1
Leishmania major	cathepsin L-like protease	0.0047	0.0527	0.1557
Brugia malayi	hypothetical protein	0.0006	0.0008	0.0018
Trypanosoma cruzi	cruzipain precursor, putative	0.0047	0.0527	0.1164
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0527	0.1818
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0527	0.1818
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0011	0.0072	0.0072
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0064	0.0153
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0006	0.0008	0.0008
Giardia lamblia	Cathepsin B precursor	0.0224	0.276	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0011	0.0072	0.0072
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0025	0.025	0.0802
Entamoeba histolytica	cysteine protease, putative	0.0034	0.0362	0.4054
Schistosoma mansoni	cathepsin s	0.0009	0.0048	0.0048
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0025	0.025	0.06
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0038	0.0415	0.089
Echinococcus granulosus	cathepsin L	0.0025	0.025	0.025
Schistosoma mansoni	hypothetical protein	0.0473	0.5901	0.5901
Echinococcus multilocularis	dnaJ subfamily B	0.0473	0.5901	0.5901
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0072	0.0072
Brugia malayi	nuclear hormone receptor	0.0011	0.0072	0.0172
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0034	0.0362	0.0362
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0527	0.1557
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0047	0.0527	0.0527
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0527	0.1818
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0011	0.0072	0.0172
Giardia lamblia	Cathepsin B precursor	0.0224	0.276	1
Onchocerca volvulus	Cathepsin L homolog	0.0047	0.0527	0.8244
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0011	0.0072	0.0172
Leishmania major	cysteine peptidase A (CPA)	0.0047	0.0527	0.1557
Loa Loa (eye worm)	hypothetical protein	0.0273	0.3385	0.8132
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0335	0.4162	0.4162
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0009	0.0048	0.0116
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.025	0.0802
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0047	0.0527	0.0527
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0415	0.0996
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0033	0.0355	0.0852
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0072	0.0172
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0025	0.025	0.025
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0025	0.025	0.06
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0224	0.276	0.276
Trypanosoma cruzi	cysteine peptidase, putative	0.0047	0.0527	0.1164
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0527	0.1557
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0025	0.025	0.025
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0011	0.0072	0.0172
Entamoeba histolytica	cysteine protease, putative	0.0034	0.0362	0.4054
Entamoeba histolytica	cysteine proteinase 2	0.0034	0.0362	0.4054
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0011	0.0072	0.0072
Entamoeba histolytica	cysteine protease, putative	0.0034	0.0362	0.4054
Brugia malayi	Cytochrome P450 family protein	0.0014	0.0115	0.0277
Loa Loa (eye worm)	fibroinase	0.0047	0.0527	0.1266
Brugia malayi	cathepsin F-like cysteine proteinase	0.0009	0.0048	0.0116
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0527	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0527	0.1557
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0072	0.0172
Echinococcus granulosus	FTZ F1 alpha	0.0011	0.0072	0.0072
Trypanosoma cruzi	cysteine proteinase, putative	0.0034	0.0362	0.0763
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0047	0.0527	0.1818
Echinococcus multilocularis	cathepsin L	0.0034	0.0362	0.0362
Entamoeba histolytica	cysteine protease, putative	0.0034	0.0362	0.4054
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0047	0.0527	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0072	0.0072
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0011	0.0072	0.0172
Onchocerca volvulus		0.0047	0.0527	0.8244
Echinococcus multilocularis	cysteine protease	0.0047	0.0527	0.0527
Loa Loa (eye worm)	hypothetical protein	0.0025	0.025	0.06
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0008	0.0018
Onchocerca volvulus		0.0047	0.0527	0.8244
Entamoeba histolytica	cysteine protease, putative	0.0034	0.0362	0.4054
Brugia malayi	photoreceptor-specific nuclear receptor	0.0011	0.0072	0.0172
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0066	0.0157
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.0008	0.0018
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0072	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0025	0.025	0.06
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0224	0.276	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0047	0.0527	0.0527
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0025	0.025	0.4207
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0072	0.0072
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0063	0.0729	0.1911
Plasmodium vivax	serine-repeat antigen (SERA)	0.0025	0.025	0.4207
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0048	0.0116
Echinococcus multilocularis	ecdysone induced protein 78C	0.0011	0.0072	0.0072
Brugia malayi	Cathepsin L-like precursor	0.0047	0.0527	0.1266
Trypanosoma cruzi	major cysteine proteinase, putative	0.0025	0.025	0.049
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0011	0.0072	0.0072
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0527	0.1818
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.007	0.0824	0.0824
Plasmodium vivax	vivapain-2	0.0047	0.0527	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0034	0.0362	0.1214
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0011	0.0072	0.0072
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0025	0.025	0.025
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0009	0.0048	0.0116
Onchocerca volvulus		0.0033	0.0355	0.5549
Echinococcus granulosus	survival motor neuron protein 1	0.0273	0.3385	0.3385
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0527	0.1266
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0011	0.0072	0.0072
Echinococcus multilocularis	cathepsin L cysteine protease	0.0047	0.0527	0.0527
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0025	0.025	0.0802
Entamoeba histolytica	cysteine protease, putative	0.0034	0.0362	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.0025	0.025	0.06
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0066	0.0066
Schistosoma mansoni	cpg binding protein	0.0033	0.0355	0.0355
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0025	0.025	0.06
Brugia malayi	nuclear receptor RXR	0.0006	0.0008	0.0018
Echinococcus granulosus	cathepsin b	0.0335	0.4162	0.4162
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0038	0.0415	0.0996
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0527	0.1557
Brugia malayi	ecdysteroid receptor	0.0011	0.0072	0.0172
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0011	0.0072	0.0072
Brugia malayi	nuclear receptor NHR-88	0.0011	0.0072	0.0172
Brugia malayi	steroid hormone receptor	0.0011	0.0072	0.0172
Entamoeba histolytica	cysteine protease, putative	0.0034	0.0362	0.4054
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0025	0.025	0.4207
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0047	0.0527	0.0527
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0011	0.0072	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0008	0.0018
Trypanosoma cruzi	cysteine peptidase, putative	0.0034	0.0362	0.0763
Entamoeba histolytica	cysteine proteinase, putative	0.0034	0.0362	0.4054
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0011	0.0072	0.0072
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0025	0.025	0.4207
Echinococcus granulosus	cathepsin b	0.0335	0.4162	0.4162
Plasmodium vivax	vivapain-3	0.0034	0.0362	0.6555
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0025	0.025	0.025
Onchocerca volvulus		0.0047	0.0527	0.8244
Echinococcus multilocularis	FTZ F1 alpha	0.0011	0.0072	0.0072
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0072	0.0072
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0025	0.025	0.025
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0224	0.276	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0038	0.0415	0.1406
Schistosoma mansoni	cathepsin S (C01 family)	0.0025	0.025	0.025
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0527	0.1818
Entamoeba histolytica	cysteine protease, putative	0.0034	0.0362	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0527	0.1818
Onchocerca volvulus		0.0038	0.0415	0.6486
Schistosoma mansoni	cathepsin C	0.0025	0.025	0.025
Echinococcus multilocularis	cathepsin b	0.0335	0.4162	0.4162
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0034	0.0362	0.0362
Entamoeba histolytica	cysteine protease, putative	0.0034	0.0362	0.4054
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0224	0.276	1
Onchocerca volvulus		0.0047	0.0527	0.8244
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0072	0.0072
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0011	0.0072	0.0172
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0025	0.025	0.0802
Echinococcus granulosus	ecdysone induced protein 78C	0.0011	0.0072	0.0072
Loa Loa (eye worm)	cysteine protease	0.0047	0.0527	0.1266
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0527	0.1818
Onchocerca volvulus	Cathepsin F homolog	0.0047	0.0527	0.8244
Schistosoma mansoni	retinoic acid receptor RXR	0.0011	0.0072	0.0072
Brugia malayi	cathepsin B-like cysteine proteinase	0.0335	0.4162	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.004	0.004
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0011	0.0072	0.1122
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0527	0.1818
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0072	0.0072
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.025	0.0802
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0025	0.025	0.4207
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0415	0.0996
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0006	0.0008	0.0008
Brugia malayi	cathepsin L-like cysteine proteinase	0.0025	0.025	0.06
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0034	0.0362	0.0763
Brugia malayi	hypothetical protein	0.0273	0.3385	0.8132
Loa Loa (eye worm)	hypothetical protein	0.0025	0.025	0.06
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0025	0.025	0.4207
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0527	0.1818
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0527	0.1818
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.0008	0.0018
Entamoeba histolytica	cysteine protease, putative	0.0034	0.0362	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.0047	0.0527	0.1266
Brugia malayi	Papain family cysteine protease containing protein	0.0034	0.0362	0.087
Onchocerca volvulus		0.0047	0.0527	0.8244
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0011	0.0072	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0008	0.0018
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0025	0.025	0.025
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0527	0.1818
Brugia malayi	Papain family cysteine protease containing protein	0.0025	0.025	0.06
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0025	0.025	0.4207
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0072	0.0072
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0038	0.0415	0.1406
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0072	0.0172
Leishmania major	cathepsin L-like protease	0.0047	0.0527	0.1557
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0527	0.1818
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0025	0.025	0.0802
Onchocerca volvulus	Bile acid receptor homolog	0.0011	0.0072	0.1122
Brugia malayi	hypothetical protein	0.0006	0.0008	0.0018
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0025	0.025	0.025
Brugia malayi	Cathepsin L-like precursor	0.0047	0.0527	0.1266
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0034	0.0362	0.0362
Echinococcus multilocularis	cathepsin b	0.0335	0.4162	0.4162
Brugia malayi	Cathepsin L-like precursor	0.0047	0.0527	0.1266
Entamoeba histolytica	cysteine proteinase, putative	0.0034	0.0362	0.4054
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0011	0.0072	0.0072
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0224	0.276	0.6593
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.025	0.0802
Brugia malayi	Cathepsin L-like precursor	0.0047	0.0527	0.1266
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0072	0.0172
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0056	0.0639	0.1536
Schistosoma mansoni	survival motor neuron protein	0.0056	0.0639	0.0639
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0072	0.0172
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0335	0.4162	0.4162
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0527	0.1557
Loa Loa (eye worm)	hypothetical protein	0.001	0.0064	0.0153
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0527	0.1818
Trypanosoma cruzi	cytochrome P450, putative	0.0014	0.0115	0.0163
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0025	0.025	0.025
Plasmodium vivax	unspecified product	0.0034	0.0362	0.6555
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0527	0.1818
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0047	0.0527	1
Leishmania major	cathepsin L-like protease	0.0047	0.0527	0.1557
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.025	0.0802
Trypanosoma cruzi	cysteine peptidase, putative	0.0047	0.0527	0.1164
Entamoeba histolytica	cysteine protease, putative	0.0034	0.0362	0.4054
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0025	0.025	0.06
Onchocerca volvulus		0.0011	0.0072	0.1122
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0047	0.0527	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0047	0.0527	0.0527
Loa Loa (eye worm)	hypothetical protein	0.0335	0.4162	1
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0034	0.0362	0.4054
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.025	0.0802
Schistosoma mansoni	coup transcription factor	0.0011	0.0072	0.0072
Brugia malayi	Papain family cysteine protease containing protein	0.0025	0.025	0.06
Brugia malayi	Cathepsin L-like precursor	0.0038	0.0415	0.0996
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0011	0.0072	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0415	0.0996
Schistosoma mansoni	cpg binding protein	0.0035	0.0379	0.0379
Schistosoma mansoni	cpg binding protein	0.0035	0.0379	0.0379
Entamoeba histolytica	cysteine protease, putative	0.0034	0.0362	0.4054
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0025	0.025	0.4207
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0011	0.0072	0.0172
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0025	0.025	0.06
Trypanosoma cruzi	cysteine protease, putative	0.0034	0.0362	0.0763
Echinococcus granulosus	cathepsin L	0.0034	0.0362	0.0362
Schistosoma mansoni	microtubule-associated protein tau	0.0798	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0527	0.1557
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0527	0.1818
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.025	0.0802
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0011	0.0072	0.0172
Echinococcus multilocularis	microtubule associated protein 2	0.0798	1	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.0011	0.0072	0.1122
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0527	1
Leishmania major	cathepsin L-like protease	0.0047	0.0527	0.1557
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0025	0.025	0.0802
Loa Loa (eye worm)	cathepsin B	0.0224	0.276	0.6632
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0011	0.0072	0.0072
Loa Loa (eye worm)	steroid hormone receptor	0.0011	0.0072	0.0172
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.025	0.0802
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0527	0.1557
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.025	0.0802
Echinococcus multilocularis	cpg binding protein	0.0035	0.0379	0.0379
Echinococcus granulosus	cpg binding protein	0.0035	0.0379	0.0379
Echinococcus multilocularis	survival motor neuron protein 1	0.0273	0.3385	0.3385
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0527	0.1818
Onchocerca volvulus		0.0047	0.0527	0.8244
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0025	0.025	0.0802
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0072	0.0172
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0527	0.1818
Toxoplasma gondii	cathepsin CPL	0.0047	0.0527	0.1105
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0527	0.1557
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0527	0.1818
Brugia malayi	cathepsin F-like cysteine proteinase	0.0025	0.025	0.06
Brugia malayi	Cathepsin L-like precursor	0.0047	0.0527	0.1266
Brugia malayi	CXXC zinc finger family protein	0.0033	0.0355	0.0852
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0527	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0527	0.1818
Loa Loa (eye worm)	hypothetical protein	0.0025	0.025	0.06
Onchocerca volvulus	Cathepsin L homolog	0.0047	0.0527	0.8244
Plasmodium vivax	vivapain-1	0.0034	0.0362	0.6555
Toxoplasma gondii	cathepsin B	0.0224	0.276	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0011	0.0072	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0072	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0048	0.0116
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0025	0.025	0.0802
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0014	0.0115	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0072	0.0172
Schistosoma mansoni	cathepsin B (C01 family)	0.0025	0.025	0.025
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0047	0.0527	0.1818
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0048	0.0116
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0527	0.1818
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0025	0.025	0.025
Leishmania major	cathepsin L-like protease	0.0047	0.0527	0.1557
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.004	0.004
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0025	0.025	0.4207
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.025	0.0802
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0008	0.0018
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0527	0.1557
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0072	0.0172
Brugia malayi	Cathepsin L-like precursor	0.0047	0.0527	0.1266
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0335	0.4162	0.4162
Schistosoma mansoni	hypothetical protein	0.0056	0.0639	0.0639
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0047	0.0527	0.1266
Leishmania major	cathepsin L-like protease	0.0047	0.0527	0.1557
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0527	0.1818
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0006	0.0008	0.0008
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0527	0.1818
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0527	0.1557
Loa Loa (eye worm)	CYP4Cod1	0.0014	0.0115	0.0277
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.025	0.0802
Brugia malayi	Cathepsin L-like precursor	0.0038	0.0415	0.0996
Echinococcus multilocularis	cysteine protease	0.0047	0.0527	0.0527
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0011	0.0072	0.0172
Brugia malayi	Papain family cysteine protease containing protein	0.0034	0.0362	0.087
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.025	0.0802
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0025	0.025	0.4207
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0025	0.025	0.0802
Brugia malayi	Cytochrome P450 family protein	0.0014	0.0115	0.0277
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.004	0.004
Entamoeba histolytica	cysteine proteinase, putative	0.0034	0.0362	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0034	0.0362	0.0933
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0011	0.0072	0.0172
Onchocerca volvulus		0.0047	0.0527	0.8244

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 0.11 uM	Antitrypanosomal activity against Trypanosoma brucei brucei 427-221a after 40 hrs by bioluminescence assay	ChEMBL.	20303767
EC50 (functional)	= 1.4 uM	Antitrypanosomal activity against Trypanosoma brucei after 48 hrs	ChEMBL.	21051236
EC50 (ADMET)	= 25 uM	Cytotoxicity against HEK293 cells	ChEMBL.	20303767
IC50 (functional)	= 0.11 uM	Antitrypanosomal activity against Trypanosoma brucei	ChEMBL.	18173229
IC50 (functional)	= 0.11 uM	Antitrypanosomal activity against Trypanosoma brucei	ChEMBL.	18173229
IC50 (binding)	= 0.27 uM	Inhibition of Trypanosoma brucei cathepsin B-like cysteine protease	ChEMBL.	18173229
IC50 (binding)	= 0.27 uM	Inhibition of Trypanosoma brucei cathepsin B-like cysteine protease	ChEMBL.	18173229
IC50 (binding)	= 0.3 uM	Inhibition of human liver cathepsin L	ChEMBL.	18173229
IC50 (binding)	= 0.3 uM	Inhibition of human liver cathepsin L	ChEMBL.	18173229
IC50 (binding)	= 5.43 uM	Inhibition of human liver cathepsin B	ChEMBL.	18173229
IC50 (binding)	= 5.43 uM	Inhibition of human liver cathepsin B	ChEMBL.	18173229
Potency (functional)	20.5962 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Stability (ADMET)	= 2 uM	Stability of the compound in po dosed mouse blood assessed as 6-(3,4-dichlorobenzylamino)-9-(3-hydroxypropyl)-9H-purine-2-carbonitrile level after 1 to 2 hrs	ChEMBL.	21051236
Stability (ADMET)	> 50 uM	Stability of the compound in po dosed mouse blood assessed as 5-(2-cyano-6-(3,4-dichlorobenzylamino)-9H-purin-9-yl)pentanoic acid level	ChEMBL.	21051236
Stability (ADMET)	> 50 uM	Stability of the compound in po dosed mouse blood assessed as 3-(2-cyano-6-(3,4-dichlorobenzylamino)-9H-purin-9-yl)propanoic acid level	ChEMBL.	21051236
T1/2 (ADMET)	= 5.1 hr	Half life in CD1 mouse plasma by UPLC-MS analysis	ChEMBL.	21051236

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Trypanosoma brucei gambiense		18173229
Trypanosoma brucei	ChEMBL23	18173229

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL254412
PubChem: 24777303

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 501609