Detailed information for compound 502400

Basic information

Technical information
  • TDR Targets ID: 502400
  • Name: 2-amino-N-[2-(naphthalen-2-ylmethylamino)ethy l]-1,3-benzothiazole-6-carboxamide
  • MW: 376.475 | Formula: C21H20N4OS
  • H donors: 3 H acceptors: 2 LogP: 3.62 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1sc2c(n1)ccc(c2)C(=O)NCCNCc1ccc2c(c1)cccc2
  • InChi: 1S/C21H20N4OS/c22-21-25-18-8-7-17(12-19(18)27-21)20(26)24-10-9-23-13-14-5-6-15-3-1-2-4-16(15)11-14/h1-8,11-12,23H,9-10,13H2,(H2,22,25)(H,24,26)
  • InChiKey: YIUWZBJYJHWFIV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-amino-N-[2-(2-naphthylmethylamino)ethyl]-1,3-benzothiazole-6-carboxamide
  • 2-amino-N-[2-(2-naphthalenylmethylamino)ethyl]-1,3-benzothiazole-6-carboxamide
  • 2-azanyl-N-[2-(naphthalen-2-ylmethylamino)ethyl]-1,3-benzothiazole-6-carboxamide
  • 6-Benzothiazolecarboxamide, 2-amino-N-[2-[(2-naphthalenylmethyl)amino]ethyl]-
  • AIDS-227205
  • AIDS227205

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Candida albicans myristoyl-CoA:protein N-myristoyltransferase that is capable of functional substitution for S. cerevisiae NMT1 (YLR195C) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense N-myristoyl transferase, putative Get druggable targets OG5_127597 All targets in OG5_127597
Cryptosporidium parvum N-myristoyltransferase Get druggable targets OG5_127597 All targets in OG5_127597
Trypanosoma cruzi N-myristoyl transferase, putative Get druggable targets OG5_127597 All targets in OG5_127597
Neospora caninum hypothetical protein Get druggable targets OG5_127597 All targets in OG5_127597
Cryptosporidium hominis N-myristoyltransferase Get druggable targets OG5_127597 All targets in OG5_127597
Leishmania mexicana N-myristoyl transferase, putative Get druggable targets OG5_127597 All targets in OG5_127597
Trypanosoma brucei N-myristoyltransferase Get druggable targets OG5_127597 All targets in OG5_127597
Giardia lamblia CDC72 Get druggable targets OG5_127597 All targets in OG5_127597
Trypanosoma brucei gambiense N-myristoyl transferase, putative Get druggable targets OG5_127597 All targets in OG5_127597
Leishmania infantum N-myristoyltransferase Get druggable targets OG5_127597 All targets in OG5_127597
Schistosoma japonicum ko:K00671 glycylpeptide N-tetradecanoyltransferase [EC2.3.1.97], putative Get druggable targets OG5_127597 All targets in OG5_127597
Trypanosoma cruzi N-myristoyl transferase, putative Get druggable targets OG5_127597 All targets in OG5_127597
Plasmodium yoelii N-myristoyltransferase Get druggable targets OG5_127597 All targets in OG5_127597
Babesia bovis myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain containing protein Get druggable targets OG5_127597 All targets in OG5_127597
Plasmodium vivax glycylpeptide N-tetradecanoyltransferase, putative Get druggable targets OG5_127597 All targets in OG5_127597
Plasmodium falciparum glycylpeptide N-tetradecanoyltransferase Get druggable targets OG5_127597 All targets in OG5_127597
Echinococcus granulosus glycylpeptide N tetradecanoyltransferase Get druggable targets OG5_127597 All targets in OG5_127597
Loa Loa (eye worm) N-myristoyltransferase 2 Get druggable targets OG5_127597 All targets in OG5_127597
Trypanosoma brucei N-myristoyl transferase, putative Get druggable targets OG5_127597 All targets in OG5_127597
Entamoeba histolytica glycylpeptide N-tetradecanoyltransferase, putative Get druggable targets OG5_127597 All targets in OG5_127597
Leishmania major N-myristoyl transferase, putative Get druggable targets OG5_127597 All targets in OG5_127597
Candida albicans myristoyl-CoA:protein N-myristoyltransferase that is capable of functional substitution for S. cerevisiae NMT1 (YLR195C) Get druggable targets OG5_127597 All targets in OG5_127597
Echinococcus multilocularis glycylpeptide N tetradecanoyltransferase Get druggable targets OG5_127597 All targets in OG5_127597
Plasmodium knowlesi glycylpeptide N-tetradecanoyltransferase, putative Get druggable targets OG5_127597 All targets in OG5_127597
Schistosoma mansoni N-myristoyltransferase Get druggable targets OG5_127597 All targets in OG5_127597
Candida albicans myristoyl-CoA:protein N-myristoyltransferase that is capable of functional substitution for S. cerevisiae NMT1 (YLR195C) Get druggable targets OG5_127597 All targets in OG5_127597
Leishmania donovani N-myristoyltransferase Get druggable targets OG5_127597 All targets in OG5_127597
Brugia malayi N-myristoyltransferase 2 Get druggable targets OG5_127597 All targets in OG5_127597
Leishmania braziliensis N-myristoyl transferase, putative Get druggable targets OG5_127597 All targets in OG5_127597
Trichomonas vaginalis N-myristoyl transferase, putative Get druggable targets OG5_127597 All targets in OG5_127597
Plasmodium berghei glycylpeptide N-tetradecanoyltransferase, putative Get druggable targets OG5_127597 All targets in OG5_127597
Theileria parva N-myristoyltransferase, putative Get druggable targets OG5_127597 All targets in OG5_127597
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Thioredoxin reductase 0.0054 0.0479 0.1696
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0252 0.0488
Schistosoma mansoni N-myristoyltransferase 0.0216 0.2482 0.3217
Brugia malayi N-myristoyltransferase 2 0.0216 0.2482 0.9104
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0046 0.0096
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0047 0.0056
Schistosoma mansoni lamin 0.0031 0.0195 0.0228
Mycobacterium tuberculosis Probable oxidoreductase 0.0136 0.1492 0.1475
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0122 0.1324 0.1307
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0086 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0086 0.013
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0036 0.0268 0.0533
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0019 0.0047 0.0027
Plasmodium vivax SET domain protein, putative 0.0034 0.0235 0.0216
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.03 0.0588
Trypanosoma brucei DNA polymerase IV, putative 0.0046 0.0392 0.0781
Leishmania major DNA polymerase kappa, putative 0.0024 0.0113 0.0194
Echinococcus multilocularis musashi 0.0031 0.0195 0.0387
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0136 0.1492 0.1475
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0392 0.0781
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0019 0.0047 0.0001
Echinococcus granulosus carboxylesterase 5A 0.0153 0.1711 0.3402
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0195 0.0646
Echinococcus granulosus glutamate receptor NMDA 0.0089 0.092 0.1828
Plasmodium vivax glutamine synthetase, putative 0.0825 1 1
Mycobacterium ulcerans DNA polymerase IV 0.0046 0.0392 0.0347
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0086 0.0171
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0086 0.0086
Toxoplasma gondii glutamine synthetase, type I, putative 0.0825 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0086 0.0086
Brugia malayi Carboxylesterase family protein 0.0026 0.0138 0.0437
Loa Loa (eye worm) PXA domain-containing protein 0.0022 0.0086 0.018
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0022 0.0086 0.0244
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0046 0.0026
Mycobacterium ulcerans DNA polymerase IV 0.0046 0.0392 0.0347
Plasmodium vivax glycylpeptide N-tetradecanoyltransferase, putative 0.0216 0.2482 0.2467
Echinococcus granulosus neuroligin 0.0026 0.0138 0.0275
Brugia malayi Carboxylesterase family protein 0.0026 0.0138 0.0437
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0122 0.1324 0.1307
Loa Loa (eye worm) N-myristoyltransferase 2 0.0216 0.2482 0.5201
Brugia malayi Carboxylesterase family protein 0.0026 0.0138 0.0437
Trypanosoma brucei trypanothione reductase 0.0054 0.0479 0.0964
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0281 0.0558
Entamoeba histolytica hypothetical protein 0.0023 0.0101 0.0329
Echinococcus multilocularis NMDA receptor 0.0024 0.0116 0.023
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0228 0.0592
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0086 0.0171
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0016 0.002 0.0041
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0036 0.0268 0.0533
Toxoplasma gondii 6-phosphofructokinase 0.0033 0.0228 0.0211
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.0824 0.1639
Mycobacterium ulcerans hypothetical protein 0.0424 0.5046 0.5023
Schistosoma mansoni ATP-binding cassette transporter 0.0024 0.0116 0.0124
Schistosoma mansoni glutamate receptor kainate 0.0024 0.0116 0.0124
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0235 0.0467
Loa Loa (eye worm) glutathione reductase 0.0054 0.0479 0.1003
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0062 0.058 0.4142
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0392 0.0781
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0022 0.0086 0.0086
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0392 0.0781
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0617 0.1256
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0101 0.1016
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0024 0.0113 0.0092
Loa Loa (eye worm) carboxylesterase 0.0026 0.0138 0.0289
Onchocerca volvulus 0.0031 0.0195 0.0122
Echinococcus multilocularis dna polymerase kappa 0.0046 0.0392 0.0779
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0047 0.0056
Trichomonas vaginalis glutathione reductase, putative 0.0019 0.0047 0.0004
Trichomonas vaginalis spcc417.12 protein, putative 0.0026 0.0138 0.03
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0101 0.0073
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.005 0.0062
Schistosoma mansoni glutamate receptor AMPA 0.0024 0.0116 0.0124
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0252 0.0488
Echinococcus multilocularis dna polymerase eta 0.0016 0.002 0.0041
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0043
Brugia malayi Carboxylesterase family protein 0.0026 0.0138 0.0437
Trypanosoma cruzi N-myristoyl transferase, putative 0.0216 0.2482 0.5181
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0101 0.0084
Mycobacterium tuberculosis Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) 0.0825 1 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0136 0.1492 0.1475
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0024 0.0116 0.023
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0019 0.0047 0.0001
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.1336 0.4189
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0392 0.0781
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0122 0.1324 0.1307
Brugia malayi hypothetical protein 0.0022 0.0086 0.0244
Loa Loa (eye worm) hypothetical protein 0.0026 0.0138 0.0289
Mycobacterium ulcerans hypothetical protein 0.0213 0.2447 0.2412
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0228 0.0592
Schistosoma mansoni glutamate receptor kainate 0.0024 0.0116 0.0124
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0047 0.0056
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0019 0.0047 0.0001
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0047 0.0056
Entamoeba histolytica phosphofructokinase, putative 0.0123 0.1336 0.5344
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0046 0.0054
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0047 0.0056
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0101 0.0056
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0016 0.002 0.0041
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0026 0.0138 0.0275
Brugia malayi Carboxylesterase family protein 0.0153 0.1711 0.6254
Schistosoma mansoni lamin 0.0031 0.0195 0.0228
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.005 0.0062
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0022 0.0086 0.018
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0392 0.0781
Loa Loa (eye worm) carboxylesterase 0.0026 0.0138 0.0289
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0019 0.0047 0.0056
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0617 0.1256
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0086 0.0171
Echinococcus multilocularis acetylcholinesterase 0.0153 0.1711 0.3402
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0086 0.0086
Echinococcus granulosus acetylcholinesterase 0.0153 0.1711 0.3402
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0062 0.058 0.0537
Echinococcus multilocularis glutamine synthetase 0.0402 0.4773 0.9487
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0617 0.1227
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0235 0.0281
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0022 0.0086 0.0171
Toxoplasma gondii NADPH-glutathione reductase 0.0019 0.0047 0.003
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0116 0.0228
Trypanosoma cruzi glutamine synthetase, putative 0.0402 0.4773 1
Leishmania major trypanothione reductase 0.0054 0.0479 0.0964
Echinococcus granulosus Regulator of G protein signaling 20 0.0022 0.0086 0.0171
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.0047 0.0056
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0113 0.0194
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.0047 0.0027
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0036 0.0268 0.0533
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0062 0.058 1
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0101 0.0056
Plasmodium falciparum glycylpeptide N-tetradecanoyltransferase 0.0216 0.2482 0.2448
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0392 0.0781
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0086 0.0086
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0047 0.0094
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0086 0.0086
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0228 0.0592
Entamoeba histolytica phosphofructokinase, putative 0.0123 0.1336 0.5344
Echinococcus granulosus dna polymerase eta 0.0016 0.002 0.0041
Echinococcus granulosus para nitrobenzyl esterase 0.0026 0.0138 0.0275
Loa Loa (eye worm) hypothetical protein 0.0026 0.0138 0.0289
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0235 0.0467
Echinococcus multilocularis glycylpeptide N tetradecanoyltransferase 0.0216 0.2482 0.4934
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0024 0.0116 0.023
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0036 0.0268 0.0533
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0047 0.0056
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0046 0.0392 0.1123
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0392 0.0781
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0086 0.0086
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0022 0.0086 0.0171
Plasmodium vivax thioredoxin reductase, putative 0.0054 0.0479 0.046
Echinococcus multilocularis glutamate receptor 2 0.0024 0.0116 0.023
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0026 0.0138 0.0154
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0235 0.0467
Echinococcus granulosus nmda type glutamate receptor 0.0102 0.1072 0.2131
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.002 0.0001
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0228 0.3399
Brugia malayi polk-prov protein 0.0035 0.0252 0.0859
Loa Loa (eye worm) hypothetical protein 0.0022 0.0086 0.018
Loa Loa (eye worm) thioredoxin reductase 0.0054 0.0479 0.1003
Toxoplasma gondii exonuclease III APE 0.0018 0.0046 0.0029
Giardia lamblia NADH oxidase lateral transfer candidate 0.0019 0.0047 0.0005
Plasmodium falciparum glutathione reductase 0.0054 0.0479 0.0435
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0122 0.1324 0.1236
Loa Loa (eye worm) hypothetical protein 0.0026 0.0138 0.0289
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0024 0.0116 0.023
Loa Loa (eye worm) hypothetical protein 0.0026 0.0138 0.0289
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0054 0.0043
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0024 0.0116 0.023
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0116 0.0228
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0026 0.0138 0.03
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0046 0.0026
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0617 0.078
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.005 0.0062
Trichomonas vaginalis glutamine synthetase, putative 0.0213 0.2447 0.7795
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0228 0.0183
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0046 0.0054
Plasmodium falciparum thioredoxin reductase 0.0054 0.0479 0.0435
Onchocerca volvulus 0.0034 0.0235 0.0209
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0122 0.1324 0.1307
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0024 0.0116 0.023
Loa Loa (eye worm) hypothetical protein 0.003 0.0188 0.0394
Loa Loa (eye worm) acetylcholinesterase 1 0.0153 0.1711 0.3586
Echinococcus multilocularis regulator of G protein signaling 0.0022 0.0086 0.0171
Trichomonas vaginalis DNA polymerase eta, putative 0.0046 0.0392 0.1123
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.1336 0.4189
Leishmania major N-myristoyl transferase, putative 0.0216 0.2482 0.5181
Brugia malayi Carboxylesterase family protein 0.0153 0.1711 0.6254
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0024 0.0116 0.023
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0047 0.0056
Trichomonas vaginalis glutamine synthetase-bacteria, putative 0.0213 0.2447 0.7795
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0086 0.0171
Loa Loa (eye worm) hypothetical protein 0.0022 0.0086 0.018
Schistosoma mansoni neuroligin 3 (S09 family) 0.0026 0.0138 0.0154
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0116 0.0356
Plasmodium vivax glutathione reductase, putative 0.0054 0.0479 0.046
Brugia malayi regulator of G-protein signaling rgs-7 0.0022 0.0086 0.0244
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0101 0.0082
Echinococcus granulosus expressed protein 0.0423 0.503 1
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0026 0.0138 0.0118
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0026 0.0138 0.0118
Trypanosoma cruzi N-myristoyl transferase, putative 0.0216 0.2482 0.5181
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0019 0.0047 0.003
Giardia lamblia CDC72 0.0216 0.2482 1
Brugia malayi phosphofructokinase 0.0123 0.1336 0.4866
Onchocerca volvulus 0.0031 0.0195 0.0122
Loa Loa (eye worm) hypothetical protein 0.0026 0.0138 0.0289
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0033 0.0228 0.0211
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0036 0.0268 0.0533
Echinococcus granulosus glutamate NMDA receptor subunit 0.0024 0.0116 0.023
Schistosoma mansoni 6-phosphofructokinase 0.0123 0.1336 0.1719
Leishmania major ATP-dependent phosphofructokinase 0.0123 0.1336 0.2769
Trichomonas vaginalis mercuric reductase, putative 0.0019 0.0047 0.0004
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0086 0.0171
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0047 0.0056
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0123 0.1336 0.2769
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0062 0.058 0.4142
Toxoplasma gondii thioredoxin reductase 0.0054 0.0479 0.0462
Mycobacterium tuberculosis Probable dehydrogenase 0.0122 0.1324 0.1307
Entamoeba histolytica phosphofructokinase, putative 0.0123 0.1336 0.5344
Brugia malayi 6-phosphofructokinase 0.0123 0.1336 0.4866
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.1336 0.4189
Plasmodium falciparum thioredoxin reductase 0.0019 0.0047 0.0001
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.1336 0.4189
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0086 0.013
Loa Loa (eye worm) hypothetical protein 0.0019 0.0056 0.0117
Mycobacterium ulcerans glutamine synthetase GlnA1 0.0825 1 1
Entamoeba histolytica hypothetical protein 0.0022 0.0086 0.0266
Schistosoma mansoni hypothetical protein 0.0024 0.0116 0.0124
Trypanosoma cruzi DNA polymerase kappa, putative 0.0046 0.0392 0.0781
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0281 0.0558
Loa Loa (eye worm) hypothetical protein 0.0082 0.0824 0.1727
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0026 0.0138 0.0154
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0101 0.0429
Loa Loa (eye worm) hypothetical protein 0.0022 0.0086 0.018
Schistosoma mansoni acetylcholinesterase 0.0026 0.0138 0.0154
Echinococcus multilocularis glutamate receptor NMDA 0.0089 0.092 0.1828
Trypanosoma cruzi DNA polymerase kappa, putative 0.0046 0.0392 0.0781
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.0824 0.2975
Mycobacterium tuberculosis Conserved hypothetical protein 0.0424 0.5046 0.5036
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0086 0.0171
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0062 0.058 0.0561
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0235 0.0218
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0047 0.0002
Loa Loa (eye worm) 6-phosphofructokinase 0.0123 0.1336 0.28
Echinococcus multilocularis thioredoxin glutathione reductase 0.0054 0.0479 0.0951
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0046 0.0096
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0086 0.0086
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0086 0.0086
Loa Loa (eye worm) carboxylesterase 0.0153 0.1711 0.3586
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.0047 0.0027
Echinococcus multilocularis para nitrobenzyl esterase 0.0026 0.0138 0.0275
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0046 0.0054
Schistosoma mansoni glutamine synthetase bacteria 0.0637 0.7674 1
Mycobacterium tuberculosis Carboxylesterase LipT 0.0026 0.0138 0.0118
Loa Loa (eye worm) hypothetical protein 0.0022 0.0086 0.018
Echinococcus granulosus beta-adrenergic receptor kinase 0.0022 0.0086 0.0171
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0047 0.0035
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0086 0.0086
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0101 0.0084
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0046 0.0091
Echinococcus granulosus glutamate receptor subunit protein glur 0.0024 0.0116 0.023
Echinococcus granulosus glycylpeptide N tetradecanoyltransferase 0.0216 0.2482 0.4934
Brugia malayi PXA domain containing protein 0.0022 0.0086 0.0244
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0086 0.0171
Loa Loa (eye worm) RGS-3 protein 0.0022 0.0086 0.018
Trypanosoma brucei N-myristoyltransferase 0.0216 0.2482 0.5181
Trypanosoma cruzi DNA polymerase kappa, putative 0.0046 0.0392 0.0781
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0228 0.0209
Mycobacterium ulcerans glutamine synthetase 0.0825 1 1
Echinococcus granulosus lamin 0.0031 0.0195 0.0387
Schistosoma mansoni BC026374 protein (S09 family) 0.0026 0.0138 0.0154
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0022 0.0086 0.018
Brugia malayi Glutamate receptor 2 precursor 0.0024 0.0116 0.0353
Loa Loa (eye worm) hypothetical protein 0.0153 0.1711 0.3586
Trypanosoma brucei N-myristoyl transferase, putative 0.0216 0.2482 0.5181
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0101 0.0056
Brugia malayi 6-phosphofructokinase 0.0123 0.1336 0.4866
Mycobacterium tuberculosis Glutamine synthetase GlnA1 (glutamine synthase) (GS-I) 0.0424 0.5046 0.5036
Echinococcus multilocularis BC026374 protein (S09 family) 0.0026 0.0138 0.0275
Schistosoma mansoni glutamine synthetase 1 2 (glutamate-amonia ligase) (gs) 0.0402 0.4773 0.6209
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0123 0.1336 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0392 0.0781
Schistosoma mansoni ap endonuclease 0.0018 0.0046 0.0033
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0047 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0086 0.013
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0022 0.0086 0.013
Echinococcus multilocularis nmda type glutamate receptor 0.0175 0.1979 0.3934
Brugia malayi regulator of G-protein signaling egl-10 0.0022 0.0086 0.0244
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0153 0.1711 0.2209
Loa Loa (eye worm) glutamate receptor 1 0.0024 0.0116 0.0242
Mycobacterium tuberculosis Probable reductase 0.0122 0.1324 0.1307
Loa Loa (eye worm) Gln-2 protein 0.0402 0.4773 1
Echinococcus granulosus lamin dm0 0.0031 0.0195 0.0387
Loa Loa (eye worm) hypothetical protein 0.0035 0.0252 0.0529
Mycobacterium ulcerans 6-phosphofructokinase 0.0123 0.1336 0.1296
Schistosoma mansoni glutamate receptor AMPA 0.0024 0.0116 0.0124
Trypanosoma brucei DNA polymerase IV, putative 0.0046 0.0392 0.0781
Wolbachia endosymbiont of Brugia malayi glutamine synthetase 0.0637 0.7674 1
Trichomonas vaginalis set domain proteins, putative 0.0268 0.3126 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0016 0.002 0.0043
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0101 0.017
Echinococcus multilocularis neuroligin 0.0026 0.0138 0.0275
Echinococcus granulosus glutamate receptor 2 0.0036 0.0268 0.0533
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0033 0.0228 0.1414
Echinococcus multilocularis nmda type glutamate receptor 0.0102 0.1072 0.2131
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.002 0.0042
Onchocerca volvulus Glutamine synthetase homolog 0.0402 0.4773 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0047 0.0056
Loa Loa (eye worm) hypothetical protein 0.0153 0.1711 0.3586
Entamoeba histolytica glutamine synthetase, putative 0.0213 0.2447 0.9855
Echinococcus multilocularis Regulator of G protein signaling 20 0.0022 0.0086 0.0171
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0228 0.0183
Echinococcus granulosus dna polymerase kappa 0.0046 0.0392 0.0779
Schistosoma mansoni z-protein (S1r protein) 0.0022 0.0086 0.0086
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0123 0.1336 0.1247
Echinococcus granulosus nmda type glutamate receptor 0.0175 0.1979 0.3934
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0617 0.1293
Toxoplasma gondii phosphofructokinase PFKII 0.0033 0.0228 0.0211
Brugia malayi glutathione reductase 0.0054 0.0479 0.1696
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0235 0.0281
Schistosoma mansoni intermediate filament proteins 0.0031 0.0195 0.0228
Echinococcus granulosus BC026374 protein S09 family 0.0026 0.0138 0.0275
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0033 0.0228 0.0749
Schistosoma mansoni glutamine synthetase bacteria 0.0637 0.7674 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0046 0.0091
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0026 0.0138 0.0275
Loa Loa (eye worm) hypothetical protein 0.0022 0.0086 0.018
Echinococcus multilocularis 6 phosphofructokinase 0.0123 0.1336 0.2656
Loa Loa (eye worm) hypothetical protein 0.0022 0.0086 0.018
Brugia malayi Pre-SET motif family protein 0.0034 0.0235 0.0795
Giardia lamblia DINP protein human, muc B family 0.0024 0.0113 0.0274
Entamoeba histolytica glutamine synthetase, putative 0.0213 0.2447 0.9855
Brugia malayi Pre-SET motif family protein 0.0236 0.2724 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0086 0.0244
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0617 0.2424
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0047 0.0002
Schistosoma mansoni ap endonuclease 0.0018 0.0046 0.0033
Onchocerca volvulus 0.0268 0.3126 0.6447
Brugia malayi A-kinase anchor protein 10, precursor 0.0022 0.0086 0.0244
Schistosoma mansoni gliotactin 0.0026 0.0138 0.0154
Brugia malayi hypothetical protein 0.0026 0.0138 0.0437
Trypanosoma brucei unspecified product 0.0039 0.03 0.0588
Brugia malayi intermediate filament protein 0.0031 0.0195 0.0646
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0086 0.013
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0036 0.0268 0.0533
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0086 0.0171
Echinococcus multilocularis lamin 0.0031 0.0195 0.0387
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0136 0.1492 0.1405
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0086 0.0171
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0086 0.0244
Echinococcus granulosus intermediate filament protein 0.0031 0.0195 0.0387
Entamoeba histolytica glycylpeptide N-tetradecanoyltransferase, putative 0.0216 0.2482 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0235 0.0493
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0036 0.0268 0.0533
Echinococcus multilocularis carboxylesterase 5A 0.0153 0.1711 0.3402
Trypanosoma cruzi DNA polymerase kappa, putative 0.0046 0.0392 0.0781
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0086 0.0086
Mycobacterium ulcerans carboxylesterase, LipT 0.0026 0.0138 0.0093
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0086 0.0171
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0019 0.0047 0.0001
Entamoeba histolytica hypothetical protein 0.0022 0.0086 0.0266
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0195 0.0408
Echinococcus multilocularis lamin dm0 0.0031 0.0195 0.0387
Schistosoma mansoni glutamate receptor NMDA 0.0024 0.0116 0.0124
Echinococcus granulosus glutamine synthetase 0.0402 0.4773 0.9487
Loa Loa (eye worm) 6-phosphofructokinase 0.0123 0.1336 0.28
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.022 0.0437
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0086 0.013
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0047 0.0056
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0019 0.0047 0.0001
Trichomonas vaginalis N-myristoyl transferase, putative 0.0142 0.1569 0.4944
Trichomonas vaginalis N-myristoyl transferase, putative 0.0216 0.2482 0.791
Loa Loa (eye worm) RecQ helicase 0.0024 0.0116 0.0244
Trypanosoma brucei glutamine synthetase, putative 0.0402 0.4773 1
Echinococcus multilocularis glutamate receptor 2 0.0036 0.0268 0.0533
Chlamydia trachomatis glutamine binding protein 0.0062 0.058 1
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0086 0.0171
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0617 0.2208
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0617 0.1227
Mycobacterium leprae GLUTAMINE SYNTHETASE GLNA1 (GLUTAMINE SYNTHASE) (Glutamate--ammonia ligase 1) (GS-I) 0.0424 0.5046 0.4995
Echinococcus multilocularis acetylcholinesterase 0.0153 0.1711 0.3402
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0086 0.0086
Loa Loa (eye worm) glutamate receptor 2 0.0024 0.0116 0.0242
Plasmodium falciparum glutamine synthetase, putative 0.0825 1 1
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0195 0.0408
Loa Loa (eye worm) hypothetical protein 0.0026 0.0138 0.0289
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0123 0.1336 0.1318
Schistosoma mansoni 6-phosphofructokinase 0.0123 0.1336 0.1719
Echinococcus granulosus thioredoxin glutathione reductase 0.0054 0.0479 0.0951
Schistosoma mansoni glutamate receptor kainate 0.0024 0.0116 0.0124
Mycobacterium tuberculosis Probable glutamine synthetase GlnA3 (glutamine synthase) (GS-I) 0.0637 0.7674 0.7669
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0086 0.013
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0036 0.0268 0.0533
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0228 0.0209
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0235 0.0281
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.008 0.0034
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0617 0.1256
Mycobacterium tuberculosis Probable glutamine synthetase GlnA4 (glutamine synthase) (GS-II) 0.0424 0.5046 0.5036
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0019 0.0047 0.0056
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0033 0.0228 0.0592
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0617 0.1256
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0123 0.1336 0.2769
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0086 0.0878 0.1745
Echinococcus granulosus bloom syndrome protein 0.0024 0.0116 0.0231
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.002 0.0001
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.0824 0.1639
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0047 0.0094
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0392 0.0781
Onchocerca volvulus 0.0082 0.0824 0.1481
Loa Loa (eye worm) hypothetical protein 0.0031 0.0195 0.0408
Echinococcus granulosus 6 phosphofructokinase 0.0123 0.1336 0.2656
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0101 0.0081
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0228 0.0592
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0047 0.0056
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0235 0.0281
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0024 0.0116 0.023
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0086 0.0171
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0047 0.01
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0022 0.0086 0.018
Trypanosoma cruzi trypanothione reductase, putative 0.0054 0.0479 0.0964
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0101 0.017
Leishmania major glutamine synthetase, putative 0.0402 0.4773 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0026 0.0138 0.0154
Brugia malayi PXA domain containing protein 0.0022 0.0086 0.0244
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0228 0.0592
Loa Loa (eye worm) hypothetical protein 0.0026 0.0138 0.0289
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0054 0.0479 0.0459
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0046 0.0054
Echinococcus granulosus acetylcholinesterase 0.0153 0.1711 0.3402
Entamoeba histolytica hypothetical protein 0.0022 0.0086 0.0266
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0046 0.0104
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0228 0.3399
Echinococcus multilocularis beta adrenergic receptor kinase 0.0022 0.0086 0.0171
Treponema pallidum NADH oxidase 0.0019 0.0047 0.0009
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0228 0.0592
Echinococcus multilocularis expressed protein 0.0423 0.503 1
Brugia malayi Glutamate receptor 1 precursor 0.0024 0.0116 0.0353
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0033 0.0228 0.0845
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0047 0.0056
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.0824 0.1051
Loa Loa (eye worm) phosphofructokinase 0.0123 0.1336 0.28
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0047 0.0056
Plasmodium falciparum glutathione reductase 0.0019 0.0047 0.0001
Schistosoma mansoni glutamate receptor NMDA 0.0126 0.1369 0.1762
Trypanosoma cruzi glutamine synthetase, putative 0.0402 0.4773 1
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0116 0.0231
Brugia malayi hypothetical protein 0.0022 0.0086 0.0244
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0024 0.0113 0.0194
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0236 0.2724 0.5709

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 10 uM Inhibition of Candida albicans N-myristoyltransferse ChEMBL. 17349719
IC50 (binding) > 10 uM Inhibition of Candida albicans N-myristoyltransferse ChEMBL. 17349719
Log IC50 (binding) = -1 uM Inhibition of Candida albicans N-myristoyltransferse ChEMBL. 17349719
Log IC50 (binding) = -1 uM Inhibition of Candida albicans N-myristoyltransferse ChEMBL. 17349719

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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