Detailed information for compound 510408

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 435.423 | Formula: C24H19F2N3O3
  • H donors: 1 H acceptors: 4 LogP: 3.56 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=Cc1ccc(cc1)c1ccc(cc1)OCC(c1ccc(cc1F)F)(Cn1cncn1)O
  • InChi: 1S/C24H19F2N3O3/c25-20-7-10-22(23(26)11-20)24(31,13-29-16-27-15-28-29)14-32-21-8-5-19(6-9-21)18-3-1-17(12-30)2-4-18/h1-12,15-16,31H,13-14H2
  • InChiKey: OYLMWOTWWNLJDR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0442 0.0617
Brugia malayi intermediate filament protein 0.0028 0.0546 0.1746
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0284 0.6928 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0422 0.243
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0074 0.1689 1
Echinococcus granulosus RUN 0.0024 0.0427 0.0412
Loa Loa (eye worm) hypothetical protein 0.0029 0.0558 0.0723
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0074 0.1689 0.1676
Onchocerca volvulus 0.0029 0.0552 0.1764
Echinococcus granulosus intermediate filament protein 0.0028 0.0546 0.0532
Mycobacterium ulcerans hypothetical protein 0.0024 0.0442 0.0617
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.0427 0.0595
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0442 0.2551
Plasmodium vivax importin-beta 2, putative 0.0029 0.0558 0.0785
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0442 0.0617
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0218 0.0269
Loa Loa (eye worm) hypothetical protein 0.0013 0.0167 0.0202
Echinococcus multilocularis musashi 0.0028 0.0546 0.0532
Schistosoma mansoni hypothetical protein 0.0305 0.7451 0.7447
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0206 0.1136
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1347 0.1926
Schistosoma mansoni hypothetical protein 0.0024 0.0427 0.0412
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0345 0.1968
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0427 0.0412
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0422 0.2501
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0558 0.0544
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0284 0.6928 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0345 0.1968
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0427 0.0412
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.018 0.0165
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1347 0.1926
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0552 0.0714
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0074 0.1689 0.1676
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0981 0.0967
Loa Loa (eye worm) hypothetical protein 0.0129 0.3055 0.4047
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0981 0.0967
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0284 0.6928 1
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.1347 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0558 0.3244
Brugia malayi RNA, U transporter 1 0.0082 0.1886 0.6154
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0442 0.2551
Trypanosoma brucei unspecified product 0.002 0.0345 0.1968
Plasmodium falciparum importin beta, putative 0.0029 0.0558 0.0785
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.1352 0.1338
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.1091 0.1077
Brugia malayi hypothetical protein 0.0024 0.0427 0.1354
Leishmania major cytochrome p450-like protein 0.0015 0.0206 0.1136
Schistosoma mansoni lamin 0.0028 0.0546 0.0532
Schistosoma mansoni cpg binding protein 0.003 0.0593 0.0578
Loa Loa (eye worm) CYP4Cod1 0.0015 0.0206 0.0253
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.1091 0.3537
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0345 0.1968
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0442 0.0617
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0059 0.0058
Schistosoma mansoni rab6-interacting 0.0024 0.0427 0.0412
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0442 0.0617
Entamoeba histolytica hypothetical protein 0.0023 0.0422 0.243
Schistosoma mansoni sex comb on midleg homolog 0.005 0.1091 0.1077
Onchocerca volvulus 0.0024 0.0427 0.1354
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0345 0.1083
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0345 0.1968
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.1091 0.1077
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0442 0.0617
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0345 0.1968
Echinococcus multilocularis ubiquitin specific protease 41 0.0074 0.1689 0.1676
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0345 0.0438
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0016 0.0093
Trypanosoma cruzi DNA polymerase eta, putative 0.0033 0.0664 0.3878
Loa Loa (eye worm) hypothetical protein 0.0018 0.029 0.0365
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0981 0.0967
Loa Loa (eye worm) hypothetical protein 0.0024 0.0427 0.0548
Loa Loa (eye worm) hypothetical protein 0.0057 0.1264 0.1662
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0345 0.2043
Loa Loa (eye worm) hypothetical protein 0.0028 0.0546 0.0707
Onchocerca volvulus 0.0028 0.0546 0.1746
Schistosoma mansoni loxhd1 0.0024 0.0427 0.0412
Onchocerca volvulus 0.0024 0.0427 0.1354
Schistosoma mansoni hypothetical protein 0.0408 1 1
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0427 0.0412
Trypanosoma brucei unspecified product 0.0014 0.0188 0.1028
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0141 0.3361 0.3351
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0016 0.0093
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0345 0.1968
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.029 0.0396
Onchocerca volvulus Huntingtin homolog 0.0129 0.3055 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0074 0.1689 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.1264 0.125
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0074 0.1689 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0345 0.1968
Onchocerca volvulus 0.005 0.1091 0.3537
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.029 0.0396
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0558 0.3244
Echinococcus granulosus dna polymerase eta 0.0047 0.1014 0.1
Schistosoma mansoni cpg binding protein 0.0029 0.0552 0.0537
Echinococcus multilocularis lamin dm0 0.0028 0.0546 0.0532
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0442 0.0617
Echinococcus granulosus lamin dm0 0.0028 0.0546 0.0532
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0265 0.0361
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.1091 0.1077
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.119 0.8822
Loa Loa (eye worm) hypothetical protein 0.0018 0.029 0.0365
Loa Loa (eye worm) hypothetical protein 0.0028 0.0533 0.0689
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.029 0.0396
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0345 0.0476
Brugia malayi Importin beta-1 subunit 0.0029 0.0558 0.1786
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0345 0.1968
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0345 0.0476
Schistosoma mansoni polycystin 1-related 0.0024 0.0427 0.0412
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0427 0.0412
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0558 0.4077
Trypanosoma cruzi DNA polymerase eta, putative 0.0047 0.1014 0.5966
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0442 0.2551
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.1347 0.1333
Loa Loa (eye worm) hypothetical protein 0.0014 0.018 0.0219
Trypanosoma brucei DNA polymerase eta, putative 0.0047 0.1014 0.5966
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.1264 0.125
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0033 0.0664 0.4873
Leishmania major importin beta-1 subunit, putative 0.0023 0.0422 0.243
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.029 0.0396
Echinococcus granulosus snurportin 1 0.0308 0.7525 0.7522
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0345 0.0476
Schistosoma mansoni intermediate filament proteins 0.0028 0.0546 0.0532
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0198 0.4773 0.4765
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0141 0.3361 0.3351
Schistosoma mansoni lamin 0.0028 0.0546 0.0532
Schistosoma mansoni hypothetical protein 0.0062 0.1383 0.137
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0345 0.1968
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0345 0.1968
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0427 0.0412
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0422 0.2501
Onchocerca volvulus Huntingtin homolog 0.0129 0.3055 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0442 0.2551
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0442 0.2551
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1347 0.1333
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0345 0.1968
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0981 0.0967
Loa Loa (eye worm) hypothetical protein 0.0018 0.029 0.0365
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0981 0.0967
Leishmania major DNA polymerase eta, putative 0.0047 0.1014 0.5966
Loa Loa (eye worm) hypothetical protein 0.0024 0.0427 0.0548
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0442 0.0617
Loa Loa (eye worm) hypothetical protein 0.0129 0.3055 0.4047
Loa Loa (eye worm) hypothetical protein 0.005 0.1091 0.1431
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.1347 0.7958
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0345 0.1968
Schistosoma mansoni DNA polymerase eta 0.0047 0.1014 0.1
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0345 0.1968
Schistosoma mansoni importin beta-1 0.0029 0.0558 0.0544
Echinococcus granulosus cpg binding protein 0.003 0.0593 0.0578
Schistosoma mansoni sex comb on midleg homolog 0.005 0.1091 0.1077
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0427 0.0548
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0345 0.033
Loa Loa (eye worm) hypothetical protein 0.0024 0.0442 0.0568
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0442 0.1404
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.018 0.0165
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0265 0.0361
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0981 0.1285
Loa Loa (eye worm) hypothetical protein 0.0047 0.1014 0.1329
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0218 0.0664
Brugia malayi mbt repeat family protein 0.005 0.1091 0.3537
Echinococcus multilocularis dna polymerase kappa 0.002 0.0345 0.033
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0546 0.1746
Echinococcus granulosus lamin 0.0028 0.0546 0.0532
Treponema pallidum hypothetical protein 0.0284 0.6928 0.5
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0345 0.033
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0442 0.1404
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0546 0.0707
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.1091 0.1077
Plasmodium vivax multidomain scavenger receptor, putative 0.0024 0.0427 0.0595
Onchocerca volvulus 0.0024 0.0442 0.1404
Trypanosoma brucei unspecified product 0.0014 0.0188 0.1028
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0981 0.0967
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0074 0.1689 0.1676
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0442 0.0617
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0981 0.0967
Brugia malayi mbt repeat family protein 0.005 0.1091 0.3537
Schistosoma mansoni cpg binding protein 0.003 0.0593 0.0578
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0074 0.1689 0.1676
Loa Loa (eye worm) hypothetical protein 0.0011 0.01 0.0112
Echinococcus granulosus importin subunit beta 1 0.0029 0.0558 0.0544
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0056 0.0133
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0442 0.0617
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0206 0.0253
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.1689 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0265 0.0361
Echinococcus granulosus polycomb protein SCMH1 0.005 0.1091 0.1077
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.1347 0.1926
Schistosoma mansoni hypothetical protein 0.0308 0.7525 0.7522
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0345 0.1968
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0345 0.0476
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0284 0.6928 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0345 0.1968
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0442 0.1404
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1347 0.1926
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0345 0.1968
Echinococcus multilocularis lamin 0.0028 0.0546 0.0532
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.1347 0.1333
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.1264 0.125
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.1264 0.125
Schistosoma mansoni hypothetical protein 0.0369 0.9037 0.9035
Loa Loa (eye worm) hypothetical protein 0.0018 0.029 0.0365
Loa Loa (eye worm) hypothetical protein 0.0024 0.0442 0.0568
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0206 0.0253
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1347 0.1333
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0345 0.033
Brugia malayi Doublecortin family protein 0.0024 0.0427 0.1354
Schistosoma mansoni lipoxygenase 0.0141 0.3361 0.3351
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0074 0.1689 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.1264 0.4107
Echinococcus granulosus ubiquitin specific protease 41 0.0074 0.1689 0.1676
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.1264 0.125
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0345 0.1968
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0198 0.4773 0.4765
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0427 0.0412
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0442 0.0617
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0074 0.1689 0.1676
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0422 0.2501
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0981 0.3175
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0345 0.1968
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0074 0.1689 0.5505
Schistosoma mansoni rab6-interacting 0.0024 0.0427 0.0412
Echinococcus multilocularis cpg binding protein 0.003 0.0593 0.0578
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0188 0.1028
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0074 0.1689 1
Leishmania major DNA polymerase kappa, putative 0.002 0.0345 0.1968
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0206 0.1136
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0308 0.7525 1
Brugia malayi Cytochrome P450 family protein 0.0015 0.0206 0.0625
Leishmania major DNA polymerase eta, putative 0.0033 0.0664 0.3878
Brugia malayi Cytochrome P450 family protein 0.0015 0.0206 0.0625
Onchocerca volvulus 0.0028 0.0546 0.1746
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0284 0.6928 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0442 0.0617
Loa Loa (eye worm) MBCTL1 0.0057 0.1264 0.1662
Schistosoma mansoni hypothetical protein 0.0369 0.9037 0.9035
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0059 0.0044
Echinococcus multilocularis dnaJ subfamily B 0.0408 1 1
Trypanosoma brucei cytochrome P450, putative 0.0015 0.0206 0.1136
Echinococcus multilocularis snurportin 1 0.0308 0.7525 0.7522
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0345 0.1968
Loa Loa (eye worm) hypothetical protein 0.0074 0.1689 0.2227
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0442 0.2551
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0074 0.1689 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0074 0.1689 1
Brugia malayi hypothetical protein 0.0129 0.3055 1
Echinococcus multilocularis geminin 0.0369 0.9037 0.9035
Echinococcus multilocularis dna polymerase eta 0.0047 0.1014 0.1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0074 0.1689 0.1676
Echinococcus granulosus geminin 0.0369 0.9037 0.9035
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0074 0.1689 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.029 0.5
Schistosoma mansoni lipoxygenase 0.0099 0.2301 0.2289
Loa Loa (eye worm) hypothetical protein 0.0013 0.0167 0.0202
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0265 0.0361
Loa Loa (eye worm) hypothetical protein 0.0024 0.0442 0.0568
Echinococcus multilocularis RUN 0.0024 0.0427 0.0412
Brugia malayi ImpB/MucB/SamB family protein 0.0047 0.1014 0.3284
Loa Loa (eye worm) mbt repeat family protein 0.005 0.1091 0.1431
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0188 0.1028
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0059 0.0044
Echinococcus granulosus dna polymerase kappa 0.002 0.0345 0.033
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0546 0.0707
Brugia malayi CXXC zinc finger family protein 0.0029 0.0552 0.1764
Brugia malayi hypothetical protein 0.0024 0.0427 0.1354
Loa Loa (eye worm) hypothetical protein 0.0018 0.029 0.0365
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0188 0.1028
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0345 0.2043
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0345 0.033
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0015 0.0206 0.0275

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 0.0625 ug ml-1 Antimicrobial activity against Candida albicans ATCC 76615 ChEMBL. 18467095
MIC (functional) = 0.0625 ug ml-1 Antimicrobial activity against Candida albicans ATCC 76615 ChEMBL. 18467095
MIC (functional) = 0.25 ug ml-1 Antimicrobial activity against Candida tropicalis isolates ChEMBL. 18467095
MIC (functional) = 0.25 ug ml-1 Antimicrobial activity against Microsporum gypseum isolates ChEMBL. 18467095
MIC (functional) = 0.25 ug ml-1 Antimicrobial activity against Fonsecaea compacta isolates ChEMBL. 18467095
MIC (functional) = 1 ug ml-1 Antimicrobial activity against Cryptococcus neoformans ATCC 32609 ChEMBL. 18467095
MIC (functional) = 1 ug ml-1 Antimicrobial activity against Trichophyton rubrum isolates ChEMBL. 18467095
MIC (functional) = 1 ug ml-1 Antimicrobial activity against Cryptococcus neoformans ATCC 32609 ChEMBL. 18467095
MIC (functional) > 64 ug ml-1 Antimicrobial activity against Cryptococcus parapsilosis isolates ChEMBL. 18467095
MIC (functional) > 64 ug ml-1 Antimicrobial activity against Aspergillus fumigatus isolates ChEMBL. 18467095

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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