Detailed information for compound 510409

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 286.111 | Formula: C12H9Cl2NO3
  • H donors: 1 H acceptors: 1 LogP: 3.38 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(c(=O)[nH]1)Oc1ccc(cc1Cl)Cl
  • InChi: 1S/C12H9Cl2NO3/c1-17-11-5-4-10(12(16)15-11)18-9-3-2-7(13)6-8(9)14/h2-6H,1H3,(H,15,16)
  • InChiKey: QETLEWLVGLUGTF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0354 0.2064
Brugia malayi intermediate filament protein 0.0029 0.0555 0.18
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0025 0.0094
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0058 0.1272 0.1251
Echinococcus multilocularis dna polymerase kappa 0.002 0.0354 0.033
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0299 0.0431
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0354 0.2064
Echinococcus multilocularis musashi 0.0029 0.0555 0.0532
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0075 0.1697 1
Schistosoma mansoni cpg binding protein 0.003 0.0601 0.0597
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0075 0.1697 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0199 0.478 0.4767
Trypanosoma cruzi DNA polymerase eta, putative 0.0033 0.0673 0.395
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0286 0.693 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0354 0.2064
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0354 0.033
Plasmodium vivax acetyl-CoA synthetase, putative 0.0007 0.0025 0.0029
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0058 0.1272 0.1251
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0025 0.0029
Echinococcus granulosus lamin 0.0029 0.0555 0.0532
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0354 0.2064
Schistosoma mansoni cpg binding protein 0.0029 0.056 0.0556
Treponema pallidum hypothetical protein 0.0286 0.693 0.5
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0354 0.051
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0075 0.1697 0.1693
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0354 0.2064
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0354 0.2064
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0555 0.0731
Onchocerca volvulus 0.0024 0.0451 0.1405
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.0025 0.0036
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0025 0.0066
Plasmodium falciparum importin beta, putative 0.0029 0.0567 0.0812
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0286 0.693 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0567 0.3325
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.1697 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0567 0.3325
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0354 0.2064
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0451 0.0645
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0354 0.051
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.1099 0.3537
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0451 0.0645
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0451 0.1461
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0025 0.0029
Schistosoma mansoni cpg binding protein 0.003 0.0601 0.0597
Echinococcus multilocularis cpg binding protein 0.003 0.0601 0.0578
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0025 0.0036
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0431 0.2501
Echinococcus granulosus dna polymerase eta 0.0048 0.1022 0.1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0189 0.0165
Trypanosoma brucei unspecified product 0.0014 0.0197 0.1135
Loa Loa (eye worm) hypothetical protein 0.0024 0.0451 0.0594
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0299 0.0425
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0354 0.0349
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1354 0.1949
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1354 0.1351
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.1099 0.1077
Loa Loa (eye worm) oxidoreductase 0.0007 0.0025 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0354 0.2064
Echinococcus granulosus importin subunit beta 1 0.0029 0.0567 0.0544
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.1354 0.1333
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0075 0.1697 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0299 0.0391
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0354 0.0504
Onchocerca volvulus 0.0029 0.0555 0.1746
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0354 0.2064
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0025 0.0119
Loa Loa (eye worm) hypothetical protein 0.0024 0.0451 0.0594
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0451 0.2641
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0555 0.0731
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.1099 0.1454
Loa Loa (eye worm) hypothetical protein 0.0007 0.0025 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0197 0.1135
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0068 0.0084
Echinococcus multilocularis lamin dm0 0.0029 0.0555 0.0532
Echinococcus multilocularis dna polymerase eta 0.0048 0.1022 0.1
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0567 0.0544
Echinococcus multilocularis ubiquitin specific protease 41 0.0075 0.1697 0.1676
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0354 0.2043
Loa Loa (eye worm) hypothetical protein 0.0051 0.1099 0.1454
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0451 0.0618
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0567 0.4167
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.0025 0.0036
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0025 0.0119
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.1099 0.1077
Brugia malayi mbt repeat family protein 0.0051 0.1099 0.358
Schistosoma mansoni lamin 0.0029 0.0555 0.0551
Loa Loa (eye worm) hypothetical protein 0.0018 0.0299 0.0391
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0068 0.0044
Brugia malayi Importin beta-1 subunit 0.0029 0.0567 0.184
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.0025 0.0119
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0555 0.18
Entamoeba histolytica hypothetical protein 0.0024 0.0431 0.243
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0354 0.2064
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0007 0.0025 0.0029
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0007 0.0025 0.0029
Mycobacterium ulcerans hypothetical protein 0.0024 0.0451 0.0645
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.1099 0.1077
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0274 0.0395
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0025 0.0119
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0065 0.0198
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1354 0.1949
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.1099 0.1077
Loa Loa (eye worm) hypothetical protein 0.013 0.3062 0.4063
Echinococcus multilocularis dnaJ subfamily B 0.0411 1 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0451 0.0651
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0025 0.0066
Loa Loa (eye worm) hypothetical protein 0.013 0.3062 0.4063
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0007 0.0025 0.0029
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0197 0.1135
Onchocerca volvulus Huntingtin homolog 0.013 0.3062 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0025 0.0029
Loa Loa (eye worm) hypothetical protein 0.0028 0.0542 0.0714
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1354 0.1351
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0025 0.0036
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0286 0.693 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0299 0.5
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0451 0.2552
Schistosoma mansoni hypothetical protein 0.0167 0.3982 0.3979
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0354 0.1968
Brugia malayi RNA, U transporter 1 0.0083 0.1894 0.618
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0451 0.0645
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0431 0.2501
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0226 0.0726
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.1354 0.1333
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0007 0.0025 0.0029
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0989 0.322
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0354 0.2043
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0274 0.0395
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0354 0.2064
Loa Loa (eye worm) hypothetical protein 0.0018 0.0299 0.0391
Leishmania major DNA polymerase kappa, putative 0.002 0.0354 0.2064
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.056 0.0738
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0451 0.0645
Echinococcus multilocularis lamin 0.0029 0.0555 0.0532
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0025 0.0029
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0007 0.0025 0.0029
Loa Loa (eye worm) hypothetical protein 0.0014 0.0189 0.0245
Loa Loa (eye worm) hypothetical protein 0.0058 0.1272 0.1684
Echinococcus granulosus cpg binding protein 0.003 0.0601 0.0578
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0354 0.1142
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0989 0.0985
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0354 0.2064
Loa Loa (eye worm) MBCTL1 0.0058 0.1272 0.1684
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0025 0.0027
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0989 0.0967
Loa Loa (eye worm) hypothetical protein 0.0018 0.0299 0.0391
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0451 0.0645
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0354 0.2064
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0007 0.0025 0.0149
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.0025 0.0036
Onchocerca volvulus 0.0051 0.1099 0.3537
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0431 0.252
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0299 0.0425
Schistosoma mansoni intermediate filament proteins 0.0029 0.0555 0.0551
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0989 0.0985
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.0025 0.002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0989 0.0967
Loa Loa (eye worm) hypothetical protein 0.0048 0.1022 0.1352
Trypanosoma brucei DNA polymerase eta, putative 0.0048 0.1022 0.6014
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0007 0.0025 0.0029
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0033 0.0673 0.4951
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0354 0.2064
Schistosoma mansoni importin beta-1 0.0029 0.0567 0.0563
Loa Loa (eye worm) hypothetical protein 0.0029 0.0555 0.0731
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0451 0.0645
Loa Loa (eye worm) hypothetical protein 0.0024 0.0451 0.0594
Brugia malayi ImpB/MucB/SamB family protein 0.0048 0.1022 0.3328
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0075 0.1697 1
Schistosoma mansoni DNA polymerase eta 0.0048 0.1022 0.1018
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0274 0.0395
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.1354 1
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0075 0.1697 0.1693
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0025 0.0066
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0451 0.2641
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0989 0.0967
Echinococcus granulosus intermediate filament protein 0.0029 0.0555 0.0532
Leishmania major DNA polymerase eta, putative 0.0048 0.1022 0.6014
Schistosoma mansoni hypothetical protein 0.0308 0.7456 0.7455
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0274 0.0395
Loa Loa (eye worm) hypothetical protein 0.0018 0.0299 0.0391
Echinococcus multilocularis geminin 0.0167 0.3982 0.3967
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0197 0.1135
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.1354 0.1954
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0354 0.2064
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0068 0.0044
Onchocerca volvulus 0.0029 0.0555 0.1746
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0451 0.1461
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0025 0.0066
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.0025 0.0036
Loa Loa (eye worm) hypothetical protein 0.0075 0.1697 0.2248
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0025 0.0036
Brugia malayi mbt repeat family protein 0.0051 0.1099 0.358
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.1359 0.1355
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0431 0.2501
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0199 0.478 0.4767
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0451 0.0645
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.0025 0.0119
Giardia lamblia DINP protein human, muc B family 0.002 0.0354 0.2064
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0989 0.1308
Echinococcus granulosus ubiquitin specific protease 41 0.0075 0.1697 0.1676
Schistosoma mansoni lamin 0.0029 0.0555 0.0551
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.1099 0.1095
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0354 0.2064
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0451 0.2552
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0025 0.0119
Loa Loa (eye worm) hypothetical protein 0.0013 0.0176 0.0228
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0354 0.033
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0075 0.1697 0.1676
Trypanosoma brucei unspecified product 0.002 0.0354 0.2064
Leishmania major DNA polymerase eta, putative 0.0033 0.0673 0.395
Loa Loa (eye worm) hypothetical protein 0.0013 0.0176 0.0228
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0025 0.0066
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0007 0.0025 0.0029
Loa Loa (eye worm) hypothetical protein 0.0029 0.0567 0.0747
Toxoplasma gondii propionate-CoA ligase 0.0007 0.0025 0.0149
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0075 0.1697 1
Echinococcus multilocularis snurportin 1 0.0311 0.7531 0.7524
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.0025 0.0036
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0007 0.0025 0.0029
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0451 0.2641
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.0025 0.0036
Brugia malayi CXXC zinc finger family protein 0.0029 0.056 0.1817
Echinococcus granulosus histone acetyltransferase MYST2 0.0058 0.1272 0.1251
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.1198 0.884
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0058 0.1272 0.4146
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.1099 0.1095
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0451 0.0651
Echinococcus granulosus geminin 0.0167 0.3982 0.3967
Trypanosoma brucei unspecified product 0.0014 0.0197 0.1135
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1354 0.1949
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0354 0.0464
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0025 0.0029
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0025 0.0027
Schistosoma mansoni myelin transcription factor 1 myt1 0.0058 0.1272 0.1268
Brugia malayi hypothetical protein 0.013 0.3062 1
Leishmania major importin beta-1 subunit, putative 0.0024 0.0431 0.252
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0226 0.0295
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0075 0.1697 0.1676
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.1099 0.1095
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0075 0.1697 0.1676
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0989 0.0967
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0451 0.0618
Trypanosoma cruzi DNA polymerase eta, putative 0.0048 0.1022 0.6014
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0024 0.002
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0075 0.1697 0.1676
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0007 0.0025 0.0149
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0025 0.0036
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0354 0.2064
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0025 0.0029
Echinococcus granulosus dna polymerase kappa 0.002 0.0354 0.033
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0354 0.0349
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0007 0.0025 0.0066
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0007 0.0025 0.0119
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0007 0.0025 0.0029
Mycobacterium ulcerans acetyl-CoA synthetase 0.0007 0.0025 0.0029
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0025 0.0119
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0189 0.0165
Plasmodium vivax importin-beta 2, putative 0.0029 0.0567 0.0812
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0354 0.0504
Onchocerca volvulus 0.0029 0.056 0.1763
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0311 0.7531 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.0058 0.1272 0.1251
Loa Loa (eye worm) hypothetical protein 0.0007 0.0025 0.0027
Schistosoma mansoni hypothetical protein 0.0411 1 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0025 0.0119
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0286 0.693 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0025 0.0029
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0299 0.0425
Echinococcus granulosus lamin dm0 0.0029 0.0555 0.0532
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0025 0.0094
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0286 0.693 1
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.0025 0.0036
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0451 0.2552
Schistosoma mansoni hypothetical protein 0.0167 0.3982 0.3979
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0354 0.2064
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0989 0.0985
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.1354 0.7978
Echinococcus granulosus snurportin 1 0.0311 0.7531 0.7524
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0075 0.1697 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0025 0.0029
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0075 0.1697 0.5534
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0451 0.1461
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0075 0.1697 1
Onchocerca volvulus Huntingtin homolog 0.013 0.3062 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0075 0.1697 1
Schistosoma mansoni hypothetical protein 0.0311 0.7531 0.7529

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 23.7 uM Inhibition of Bacillus anthracis Enoyl ACP reductase ChEMBL. 18499454
IC50 (binding) = 23.7 uM Inhibition of Bacillus anthracis Enoyl ACP reductase ChEMBL. 18499454
MIC (functional) > 100 ug ml-1 Antibacterial activity against Bacillus anthracis dANR ChEMBL. 18499454

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.