Detailed information for compound 515890

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 402.448 | Formula: C19H26N6O4
  • H donors: 4 H acceptors: 6 LogP: 0.5 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)NC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@H]1C[C@@H]2C[C@@H]1CC2
  • InChi: 1S/C19H26N6O4/c1-9(26)20-6-13-15(27)16(28)19(29-13)25-8-23-14-17(21-7-22-18(14)25)24-12-5-10-2-3-11(12)4-10/h7-8,10-13,15-16,19,27-28H,2-6H2,1H3,(H,20,26)(H,21,22,24)/t10-,11-,12-,13+,15+,16+,19+/m0/s1
  • InChiKey: HZBKHRPHVFUPEY-OAXCLTTPSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adenosine A1 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi hypothetical protein adenosine A1 receptor 326 aa 305 aa 21.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0512 0.0512
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0035 0.0512 0.0835
Trichomonas vaginalis poly(p)/ATP NAD kinase, putative 0.0331 0.6257 0.894
Schistosoma mansoni lamin 0.0046 0.0717 0.0717
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Onchocerca volvulus 0.0035 0.0512 0.0716
Echinococcus multilocularis NAD kinase domain containing protein 1 0.0027 0.0352 0.0352
Schistosoma mansoni lipoxygenase 0.0044 0.0683 0.0683
Plasmodium falciparum LCCL domain-containing protein 0.0016 0.0132 0.054
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.001 0.0012 0.0048
Brugia malayi GMP reductase 0.0029 0.0396 0.0646
Schistosoma mansoni amine GPCR 0.0035 0.0512 0.0512
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0035 0.0512 0.0512
Schistosoma mansoni adenosylhomocysteinase 0.0083 0.1441 0.1441
Loa Loa (eye worm) hypothetical protein 0.0015 0.0123 0.0201
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0044 0.0683 0.0683
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0035 0.0512 0.0512
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0035 0.0512 0.0512
Echinococcus granulosus serotonin receptor 0.0035 0.0512 0.0512
Echinococcus granulosus g protein coupled receptor 0.0035 0.0512 0.0512
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0035 0.0512 0.0512
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.0729 0.0729
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0012 0.0017
Echinococcus multilocularis adenosylhomocysteinase 0.0134 0.2436 0.2436
Onchocerca volvulus NAD kinase 2, mitochondrial homolog 0.0027 0.0352 0.0487
Echinococcus granulosus adenosylhomocysteinase 0.0134 0.2436 0.2436
Loa Loa (eye worm) intermediate filament protein 0.0046 0.0717 0.117
Schistosoma mansoni hypothetical protein 0.0035 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.002
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0012 0.0017
Schistosoma mansoni hypothetical protein 0.0035 0.0512 0.0512
Brugia malayi hypothetical protein 0.0035 0.0512 0.0835
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0512 0.0512
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0512 0.0512
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.0729 0.0729
Schistosoma mansoni poly(p)/ATP NAD kinase 0.0027 0.0352 0.0352
Echinococcus granulosus g protein coupled receptor 0.0035 0.0512 0.0512
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0021 0.0239 0.039
Loa Loa (eye worm) hypothetical protein 0.0254 0.4755 0.7759
Trypanosoma brucei RNA helicase, putative 0.0253 0.4738 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0065 0.1087 0.1773
Entamoeba histolytica protein kinase, putative 0.0027 0.0356 0.142
Plasmodium vivax multidomain scavenger receptor, putative 0.0016 0.0132 0.054
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0512 0.0512
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0071 0.1199 0.1199
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0512 0.0512
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.001 0.0012 0.0001
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0035 0.0512 0.0835
Schistosoma mansoni dishevelled 0.0013 0.0087 0.0087
Brugia malayi G protein-coupled receptor F59B2.13 0.0035 0.0512 0.0835
Brugia malayi hypothetical protein 0.0035 0.0512 0.0835
Entamoeba histolytica hypothetical protein 0.0015 0.0123 0.0458
Trichomonas vaginalis poly(p)/ATP NAD kinase, putative 0.0331 0.6257 0.894
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0512 0.0512
Trichomonas vaginalis guanylate cyclase, putative 0.001 0.0012 0.0017
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0035 0.0512 0.0835
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0035 0.0512 0.0716
Echinococcus granulosus son of sevenless 1 0.001 0.0012 0.0012
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0045 0.0709 0.1157
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0035 0.0512 0.0512
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0065 0.1087 0.1773
Echinococcus granulosus regulator of G protein signaling 7 0.0029 0.0385 0.0385
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0123 0.0176
Loa Loa (eye worm) hypothetical protein 0.0015 0.0123 0.0201
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.001 0.0012 0.0048
Schistosoma mansoni adenosylhomocysteinase 0.0083 0.1441 0.1441
Loa Loa (eye worm) hypoxia-induced factor 1 0.0114 0.2045 0.3337
Brugia malayi RasGEF domain containing protein 0.001 0.0012 0.002
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Onchocerca volvulus 0.0035 0.0512 0.0716
Brugia malayi hypothetical protein 0.0223 0.4157 0.6785
Echinococcus granulosus RUN 0.0016 0.0132 0.0132
Onchocerca volvulus 0.0035 0.0512 0.0716
Schistosoma mansoni amine GPCR 0.0035 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0047 0.0731 0.1193
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Schistosoma mansoni adenoreceptor 0.0035 0.0512 0.0512
Echinococcus multilocularis serotonin receptor 0.0035 0.0512 0.0512
Echinococcus granulosus Regulator of G protein signaling 20 0.0015 0.0123 0.0123
Loa Loa (eye worm) RasGEF domain-containing protein 0.001 0.0012 0.002
Onchocerca volvulus 0.0369 0.6998 1
Echinococcus multilocularis orexin receptor type 2 0.0035 0.0512 0.0512
Loa Loa (eye worm) adenosylhomocysteinase 0.0134 0.2436 0.3975
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Brugia malayi Adenosylhomocysteinase 0.0134 0.2436 0.3975
Toxoplasma gondii NAD(+)/NADH kinase domain-containing protein 0.0027 0.0352 0.1443
Schistosoma mansoni biogenic amine receptor 0.0035 0.0512 0.0512
Schistosoma mansoni hypothetical protein 0.0035 0.0512 0.0512
Echinococcus multilocularis neuropeptide receptor 0.0035 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0027 0.0352 0.0574
Echinococcus granulosus neuropeptide s receptor 0.0384 0.7295 0.7295
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0035 0.0512 0.0512
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0028 0.037 0.078
Loa Loa (eye worm) RasGEF domain-containing protein 0.001 0.0012 0.002
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0019
Treponema pallidum hypothetical protein 0.0331 0.6257 1
Schistosoma mansoni hypothetical protein 0.0045 0.0709 0.0709
Giardia lamblia Inorganic polyphosphate/ATP-NAD kinase, putative 0.0331 0.6257 1
Brugia malayi putative neuropeptide receptor 0.0035 0.0512 0.0835
Brugia malayi RasGEF domain containing protein 0.001 0.0012 0.002
Loa Loa (eye worm) hypothetical protein 0.0274 0.5149 0.8402
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0512 0.0512
Echinococcus granulosus regulator of G protein signaling 7 0.0029 0.0385 0.0385
Onchocerca volvulus 0.0045 0.0709 0.0998
Echinococcus granulosus fmrfamide receptor 0.0035 0.0512 0.0512
Brugia malayi RNase H family protein 0.0067 0.1135 0.1852
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.0134 0.2436 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0028 0.037 0.1518
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0074 0.1262 0.1262
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0025 0.0313 0.0527
Echinococcus multilocularis Protein son of sevenless 0.001 0.0012 0.0012
Schistosoma mansoni amine GPCR 0.0035 0.0512 0.0512
Echinococcus granulosus hypothetical protein 0.0035 0.0512 0.0512
Brugia malayi hypothetical protein 0.0035 0.0512 0.0835
Toxoplasma gondii IMP dehydrogenas 0.0071 0.1199 0.4923
Onchocerca volvulus 0.0016 0.0132 0.0172
Echinococcus granulosus regulator of G protein signaling 3 0.0015 0.0123 0.0123
Echinococcus multilocularis G-protein coupled receptor, putative 0.0035 0.0512 0.0512
Echinococcus granulosus peptide allatostatin:somatostatin 0.0035 0.0512 0.0512
Loa Loa (eye worm) RGS-3 protein 0.0015 0.0123 0.0201
Echinococcus granulosus survival motor neuron protein 1 0.0223 0.4157 0.4157
Loa Loa (eye worm) IMP dehydrogenase 1 0.0071 0.1199 0.1957
Echinococcus granulosus serine:threonine protein kinase:endoribonuclease 0.0027 0.0356 0.0356
Echinococcus granulosus dro:myosuppressin receptor 0.0035 0.0512 0.0512
Schistosoma mansoni hypothetical protein 0.0253 0.4738 0.4738
Trichomonas vaginalis ras GTP exchange factor, putative 0.001 0.0012 0.0017
Brugia malayi A-kinase anchor protein 10, precursor 0.0015 0.0123 0.0201
Brugia malayi Tachykinin-like peptides receptor 99D 0.0035 0.0512 0.0835
Echinococcus granulosus beta-adrenergic receptor kinase 0.0015 0.0126 0.0126
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0353 0.0504
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0123 0.0176
Brugia malayi N-terminal motif family protein 0.001 0.0012 0.002
Echinococcus multilocularis microtubule associated protein 2 0.0523 1 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0035 0.0512 0.0512
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0034 0.0478 0.0206
Loa Loa (eye worm) G-protein coupled receptor 0.0035 0.0512 0.0835
Entamoeba histolytica protein kinase, putative 0.0027 0.0356 0.142
Trypanosoma cruzi hypothetical protein 0.001 0.0012 0.0049
Echinococcus multilocularis regulator of G protein signaling 0.0015 0.0123 0.0123
Echinococcus multilocularis beta adrenergic receptor kinase 0.0015 0.0126 0.0126
Echinococcus granulosus neuropeptides capa receptor 0.0035 0.0512 0.0512
Brugia malayi hypothetical protein 0.0016 0.0132 0.0215
Trichomonas vaginalis guanylate cyclase, putative 0.001 0.0012 0.0017
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0071 0.1199 0.1636
Echinococcus multilocularis serine:threonine protein kinase:endoribonuclease 0.0027 0.0356 0.0356
Onchocerca volvulus 0.0035 0.0512 0.0716
Schistosoma mansoni regulator of G protein signaling 0.0015 0.0123 0.0123
Echinococcus granulosus lipoxygenase domain containing protein 0.0016 0.0132 0.0132
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0067 0.1135 0.9246
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0071 0.1199 0.4923
Echinococcus multilocularis axis inhibition protein axin 0.0015 0.0123 0.0123
Brugia malayi hypothetical protein 0.0035 0.0512 0.0835
Brugia malayi cytoplasmic intermediate filament protein 0.0025 0.0303 0.0494
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.001 0.0012 0.0012
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0071 0.1199 0.4923
Echinococcus multilocularis axis inhibition protein axin 0.0015 0.0123 0.0123
Echinococcus granulosus intermediate filament protein 0.0046 0.0717 0.0717
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0512 0.0512
Echinococcus multilocularis RUN 0.0016 0.0132 0.0132
Echinococcus granulosus 7TM GPCR rhodopsin 0.0035 0.0512 0.0512
Echinococcus multilocularis g protein coupled receptor 0.0035 0.0512 0.0512
Schistosoma mansoni alpha-1 adrenergic receptor 0.0035 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0512 0.0512
Brugia malayi DIX domain containing protein 0.0013 0.0087 0.0142
Schistosoma mansoni axis inhibition protein axin 0.0015 0.0123 0.0123
Loa Loa (eye worm) IRE protein kinase 0.0027 0.0356 0.0581
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0065 0.1087 0.1087
Trypanosoma cruzi hypothetical protein 0.001 0.0012 0.0049
Loa Loa (eye worm) DIX domain-containing protein 0.0013 0.0087 0.0142
Loa Loa (eye worm) hypothetical protein 0.0124 0.2232 0.3642
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0123 0.0176
Schistosoma mansoni biogenic amine (5HT) receptor 0.0035 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Brugia malayi follicle stimulating hormone receptor 0.021 0.3903 0.637
Plasmodium falciparum adenosylhomocysteinase 0.0134 0.2436 1
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.001 0.0012 0.0012
Echinococcus granulosus neuropeptide Y receptor 0.0035 0.0512 0.0512
Echinococcus multilocularis neuropeptide receptor 0.0035 0.0512 0.0512
Echinococcus granulosus tm gpcr rhodopsin 0.0035 0.0512 0.0512
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0035 0.0512 0.0512
Brugia malayi larval opioid receptor 0.0035 0.0512 0.0835
Echinococcus multilocularis neuropeptide Y receptor 0.0035 0.0512 0.0512
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.001 0.0012 0.0017
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.001 0.0015 0.0061
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.1246 0.2631
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0035 0.0512 0.0512
Echinococcus multilocularis fmrfamide receptor 0.0035 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Echinococcus granulosus orexin receptor type 2 0.0035 0.0512 0.0512
Leishmania major ribonuclease H1, putative 0.0067 0.1135 0.4661
Schistosoma mansoni single-minded 0.0037 0.0542 0.0542
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0035 0.0512 0.0512
Loa Loa (eye worm) neuropeptide F receptor 0.0035 0.0512 0.0835
Onchocerca volvulus Neuropeptide F receptor homolog 0.0035 0.0512 0.0716
Trypanosoma cruzi ribonuclease H1, putative 0.0067 0.1135 0.4661
Mycobacterium leprae putative S-adenosyl-L-homocysteine hydrolase SahH 0.0134 0.2436 0.4239
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0035 0.0512 0.0512
Leishmania major protein kinase, putative 0.001 0.0015 0.0061
Schistosoma mansoni loxhd1 0.0016 0.0132 0.0132
Brugia malayi Inositol-1 0.0028 0.037 0.0603
Schistosoma mansoni ras GTP exchange factor 0.001 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0016 0.0132 0.0132
Onchocerca volvulus 0.0027 0.0356 0.0493
Echinococcus multilocularis neuropeptides capa receptor 0.0035 0.0512 0.0512
Echinococcus multilocularis ribonuclease H1 0.0067 0.1135 0.1135
Echinococcus multilocularis sex peptide receptor 0.0035 0.0512 0.0512
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0035 0.0512 0.0835
Echinococcus multilocularis g-protein coupled receptor 0.0035 0.0512 0.0512
Brugia malayi hypothetical protein 0.0097 0.1717 0.2801
Onchocerca volvulus 0.0047 0.0731 0.103
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0074 0.1262 0.5179
Onchocerca volvulus 0.001 0.0012 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Onchocerca volvulus 0.0035 0.0512 0.0716
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0074 0.1262 0.1262
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0074 0.1262 0.1262
Echinococcus granulosus segment polarity protein dishevelled 0.0013 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Echinococcus granulosus segment polarity protein dishevelled 0.0013 0.0087 0.0087
Echinococcus multilocularis serotonin receptor 0.0035 0.0512 0.0512
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0512 0.0512
Echinococcus multilocularis tumor protein p63 0.0318 0.6016 0.6016
Echinococcus granulosus tm gpcr rhodopsin 0.0035 0.0512 0.0512
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0134 0.2436 0.348
Loa Loa (eye worm) hypothetical protein 0.0027 0.0352 0.0574
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0035 0.0512 0.0512
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0013 0.0087 0.0087
Onchocerca volvulus 0.0035 0.0512 0.0716
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0029 0.0385 0.0628
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Echinococcus granulosus biogenic amine 5HT receptor 0.0035 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0123 0.0176
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0035 0.0512 0.0512
Echinococcus granulosus aryl hydrocarbon receptor 0.001 0.0012 0.0012
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0042 0.0645 0.0921
Brugia malayi N-terminal motif family protein 0.0274 0.5149 0.8402
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Schistosoma mansoni rab6-interacting 0.0016 0.0132 0.0132
Brugia malayi G-protein coupled receptor 0.0035 0.0512 0.0835
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0035 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Schistosoma mansoni biogenic amine receptor 0.0035 0.0512 0.0512
Onchocerca volvulus 0.0047 0.0729 0.1027
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0047 0.0729 0.0729
Schistosoma mansoni neuropeptide F-like receptor 0.0035 0.0512 0.0512
Echinococcus granulosus 7tm_1 domain containing protein 0.0035 0.0512 0.0512
Schistosoma mansoni microtubule-associated protein tau 0.0523 1 1
Brugia malayi Pre-SET motif family protein 0.0324 0.6128 1
Echinococcus granulosus Polycystic kidney disease protein 0.0016 0.0132 0.0132
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0028 0.037 0.0023
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0035 0.0512 0.0835
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0015 0.0126 0.0206
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0126 0.0126
Schistosoma mansoni opsin-like receptor 0.0035 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.002
Schistosoma mansoni axis inhibition protein axin 0.0015 0.0123 0.0123
Brugia malayi intermediate filament protein 0.0046 0.0717 0.117
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0066 0.1117 0.4588
Schistosoma mansoni neuropeptide receptor 0.0035 0.0512 0.0512
Echinococcus granulosus g-protein coupled receptor 0.0035 0.0512 0.0512
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0035 0.0512 0.0512
Brugia malayi N-terminal motif family protein 0.001 0.0012 0.002
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.001 0.0012 0.0012
Brugia malayi Serotonin receptor 0.0035 0.0512 0.0835
Toxoplasma gondii adenosylhomocysteinase, putative 0.0134 0.2436 1
Echinococcus multilocularis segment polarity protein dishevelled 0.0013 0.0087 0.0087
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0073 0.1246 0.2631
Echinococcus multilocularis neuropeptide FF receptor 2 0.0035 0.0512 0.0512
Onchocerca volvulus 0.0016 0.0132 0.0172
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0035 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0015 0.0123 0.0201
Schistosoma mansoni lamin 0.0046 0.0717 0.0717
Onchocerca volvulus 0.0035 0.0512 0.0716
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0512 0.0512
Echinococcus multilocularis neuropeptide receptor A26 0.0384 0.7295 0.7295
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0028 0.037 0.1518
Mycobacterium leprae Inorganic polyphosphate/ATP-NAD kinase PpnK (Poly(P)/ATP NAD kinase) 0.0304 0.573 1
Schistosoma mansoni neuropeptide receptor 0.0035 0.0512 0.0512
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0046 0.0717 0.117
Brugia malayi hypothetical protein 0.0035 0.0512 0.0835
Mycobacterium tuberculosis Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) 0.0134 0.2436 0.3919
Schistosoma mansoni z-protein (S1r protein) 0.0029 0.0385 0.0385
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0729 0.0729
Trichomonas vaginalis ribonuclease H1, putative 0.0067 0.1135 0.1622
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0071 0.1199 0.1429
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.001 0.0012 0.0012
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0047 0.0729 0.0729
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0274 0.5149 0.7353
Echinococcus granulosus neuropeptide receptor 0.0035 0.0512 0.0512
Brugia malayi Dopamine receptor protein 1 0.0035 0.0512 0.0835
Echinococcus granulosus neuropeptide receptor 0.0035 0.0512 0.0512
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0015 0.0126 0.0206
Echinococcus multilocularis neuropeptide Y receptor 0.0035 0.0512 0.0512
Brugia malayi neuropeptide F receptor 0.0035 0.0512 0.0835
Schistosoma mansoni histamine h1 receptor 0.0035 0.0512 0.0512
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0071 0.1199 0.2077
Echinococcus granulosus tm gpcr rhodopsin 0.0035 0.0512 0.0512
Trypanosoma brucei unspecified product 0.0073 0.1246 0.2631
Schistosoma mansoni phosphoglucomutase 0.0067 0.1135 0.1135
Trypanosoma brucei GMP reductase 0.0071 0.1199 0.2531
Loa Loa (eye worm) hypothetical protein 0.0074 0.1262 0.2059
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0015 0.0126 0.0206
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0015 0.0123 0.0123
Echinococcus multilocularis g protein coupled receptor 0.0035 0.0512 0.0512
Plasmodium vivax adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative 0.0134 0.2436 1
Echinococcus granulosus lamin 0.0046 0.0717 0.0717
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0047 0.0729 0.2994
Mycobacterium ulcerans S-adenosyl-L-homocysteine hydrolase 0.0134 0.2436 0.3524
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0037 0.0547 0.0432
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0015 0.0123 0.0123
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0066 0.1117 0.4588
Echinococcus multilocularis lipoxygenase domain containing protein 0.0016 0.0132 0.0132
Mycobacterium ulcerans inorganic polyphosphate/ATP-NAD kinase 0.0331 0.6257 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0035 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0282 0.5308 0.8393
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.001 0.0012 0.0017
Schistosoma mansoni amine GPCR 0.0035 0.0512 0.0512
Echinococcus multilocularis regulator of G protein signaling 7 0.0029 0.0385 0.0385
Loa Loa (eye worm) G-protein coupled receptor 0.0035 0.0512 0.0835
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0065 0.1087 0.1087
Echinococcus multilocularis regulator of G protein signaling 7 0.0029 0.0385 0.0385
Entamoeba histolytica hypothetical protein 0.0015 0.0123 0.0458
Schistosoma mansoni cellular tumor antigen P53 0.0047 0.0731 0.0731
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0028 0.037 0.0528
Echinococcus multilocularis son of sevenless 1 0.001 0.0012 0.0012
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0512 0.0512
Loa Loa (eye worm) follicle stimulating hormone receptor 0.021 0.3903 0.637
Echinococcus multilocularis lamin 0.0046 0.0717 0.0717
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0123 0.0176
Echinococcus granulosus axis inhibition protein axin 0.0015 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0013 0.0087 0.0142
Brugia malayi Regulator of G protein signaling domain containing protein 0.0015 0.0123 0.0201
Schistosoma mansoni poly(p)/ATP NAD kinase 0.0331 0.6257 0.6257
Entamoeba histolytica hypothetical protein 0.0015 0.0123 0.0458
Loa Loa (eye worm) inositol-1 0.0028 0.037 0.0603
Echinococcus multilocularis Regulator of G protein signaling 20 0.0015 0.0123 0.0123
Leishmania major protein kinase, putative 0.0016 0.013 0.0533
Schistosoma mansoni inositol monophosphatase 0.0028 0.037 0.037
Trichomonas vaginalis poly(p)/ATP NAD kinase, putative 0.0027 0.0352 0.0502
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0035 0.0512 0.0512
Loa Loa (eye worm) GMP reductase 0.0029 0.0396 0.0646
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Trichomonas vaginalis set domain proteins, putative 0.0369 0.6998 1
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0009 0.0003 0.0003
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.001 0.0015 0.0061
Echinococcus granulosus alpha 1A adrenergic receptor 0.0035 0.0512 0.0512
Echinococcus multilocularis expressed protein 0.0298 0.5625 0.5625
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Schistosoma mansoni neuropeptide receptor 0.0035 0.0512 0.0512
Brugia malayi hypothetical protein 0.0035 0.0512 0.0835
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0029 0.0396 0.0646
Echinococcus granulosus NAD kinase 0.0331 0.6257 0.6257
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0015 0.0123 0.0123
Schistosoma mansoni phosphoglucomutase 0.0067 0.1135 0.1135
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0282 0.5308 0.9221
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Schistosoma mansoni regulator of G protein signaling 0.0015 0.0123 0.0123
Brugia malayi Regulator of G protein signaling domain containing protein 0.0015 0.0123 0.0201
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0044 0.0683 0.0683
Echinococcus multilocularis neuropeptides capa receptor 0.0035 0.0512 0.0512
Echinococcus multilocularis segment polarity protein dishevelled 0.0013 0.0087 0.0087
Onchocerca volvulus 0.0013 0.0087 0.0108
Echinococcus granulosus Protein son of sevenless 0.001 0.0012 0.0012
Leishmania major guanosine monophosphate reductase 0.0071 0.1199 0.4923
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.001 0.0012 0.0012
Toxoplasma gondii S-Adenosyl homocysteine hydrolase 0.0134 0.2436 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Loa Loa (eye worm) hypothetical protein 0.0016 0.0132 0.0215
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0035 0.0512 0.0835
Echinococcus granulosus expressed protein 0.0298 0.5625 0.5625
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0022 0.0255 0.0255
Echinococcus granulosus neuropeptides capa receptor 0.0035 0.0512 0.0512
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0071 0.1199 1
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0356 0.0356
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.001 0.0012 0.0048
Brugia malayi Doublecortin family protein 0.0016 0.0132 0.0215
Echinococcus granulosus Pleckstrin G protein interacting region 0.0013 0.0087 0.0087
Echinococcus granulosus tumor protein p63 0.0318 0.6016 0.6016
Echinococcus granulosus NAD kinase domain containing protein 1 0.0027 0.0352 0.0352
Onchocerca volvulus 0.0035 0.0512 0.0716
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Echinococcus multilocularis regulator of G protein signaling 3 0.0015 0.0123 0.0123
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0028 0.037 0.1476
Echinococcus multilocularis lamin dm0 0.0046 0.0717 0.0717
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Echinococcus granulosus neuropeptide Y receptor 0.0035 0.0512 0.0512
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0035 0.0512 0.0512
Echinococcus multilocularis somatostatin receptor 0.0035 0.0512 0.0512
Trichomonas vaginalis ras GTP exchange factor, putative 0.001 0.0012 0.0017
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.001 0.0012 0.0017
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Brugia malayi sulfakinin receptor protein 0.0035 0.0512 0.0835
Loa Loa (eye worm) hypothetical protein 0.0029 0.0385 0.0628
Brugia malayi GnHR receptor homolog 0.0035 0.0512 0.0835
Brugia malayi regulator of G-protein signaling egl-10 0.0029 0.0385 0.0628
Schistosoma mansoni dep domain containing protein 0.0013 0.0087 0.0087
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0013 0.0087 0.0142
Schistosoma mansoni rab6-interacting 0.0016 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.001 0.0012 0.0017
Echinococcus granulosus axis inhibition protein axin 0.0015 0.0123 0.0123
Onchocerca volvulus 0.0035 0.0512 0.0716
Brugia malayi Pre-SET motif family protein 0.0047 0.0729 0.119
Brugia malayi hypothetical protein 0.0035 0.0512 0.0835
Loa Loa (eye worm) neuropeptide F receptor 0.0035 0.0512 0.0835
Onchocerca volvulus 0.0035 0.0512 0.0716
Brugia malayi AKH receptor 0.0035 0.0512 0.0835
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0512 0.0512
Schistosoma mansoni survival motor neuron protein 0.0045 0.0709 0.0709
Brugia malayi Melatonin receptor type 1A 0.0035 0.0512 0.0835
Leishmania major ATP-NAD kinase-like protein 0.0027 0.0352 0.1443
Schistosoma mansoni hypothetical protein 0.0035 0.0512 0.0512
Echinococcus granulosus g protein coupled receptor 0.0035 0.0512 0.0512
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0074 0.1262 0.2016
Echinococcus multilocularis aryl hydrocarbon receptor 0.001 0.0012 0.0012
Brugia malayi putative neuropeptide receptor NPR1 0.0035 0.0512 0.0835
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.001 0.0012 0.5
Brugia malayi Intermediate filament tail domain containing protein 0.0046 0.0717 0.117
Brugia malayi Ribonuclease 2-5A family protein 0.0027 0.0356 0.0581
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0512 0.0512
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0071 0.1199 0.1199
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.001 0.0012 0.0017
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Echinococcus multilocularis transfer RNA-Lys 0.0027 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Schistosoma mansoni neuropeptide receptor 0.0035 0.0512 0.0512
Trypanosoma brucei ATP-NAD kinase-like protein 0.0027 0.0352 0.0742
Echinococcus granulosus regulator of G protein signaling 3 0.0015 0.0123 0.0123
Brugia malayi RNase H family protein 0.0067 0.1135 0.1852
Echinococcus multilocularis regulator of G protein signaling 3 0.0015 0.0123 0.0123
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0066 0.1117 0.129
Echinococcus multilocularis NAD kinase 0.0331 0.6257 0.6257
Onchocerca volvulus 0.0046 0.0717 0.1009
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.001 0.0012 0.0012
Schistosoma mansoni biogenic amine (5HT) receptor 0.0035 0.0512 0.0512
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0071 0.1199 0.1957
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0034 0.0478 0.0815
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.001 0.0015 0.0061
Brugia malayi hypothetical protein 0.0015 0.0123 0.0201
Trypanosoma brucei S-adenosylhomocysteine hydrolase, putative 0.0134 0.2436 0.5141
Schistosoma mansoni dishevelled 0.0013 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Entamoeba histolytica inorganic polyphosphate/ATP-NAD kinase, putative 0.0027 0.0352 0.1401
Echinococcus granulosus inositol monophosphatase 1 0.0028 0.037 0.037
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Schistosoma mansoni inositol monophosphatase 0.0028 0.037 0.037
Onchocerca volvulus 0.0035 0.0512 0.0716
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.001 0.0012 0.0012
Echinococcus multilocularis g protein coupled receptor 0.0035 0.0512 0.0512
Schistosoma mansoni aryl hydrocarbon receptor 0.0037 0.0542 0.0542
Schistosoma mansoni adenosylhomocysteinase 0.0083 0.1441 0.1441
Schistosoma mansoni regulator of G protein signaling 0.0015 0.0123 0.0123
Trypanosoma cruzi GMP reductase 0.0071 0.1199 0.4923
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0035 0.0512 0.0512
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0047 0.0729 0.119
Schistosoma mansoni biogenic amine receptor 0.0035 0.0512 0.0512
Brugia malayi hypothetical protein 0.0013 0.0087 0.0142
Trypanosoma brucei ingi protein (ORF1) 0.0073 0.1246 0.2631
Plasmodium vivax SET domain protein, putative 0.0047 0.0729 0.2994
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0035 0.0512 0.0512
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0028 0.037 0.1518
Leishmania major inosine-5-monophosphate dehydrogenase 0.0071 0.1199 0.4923
Schistosoma mansoni opsin-like receptor 0.0035 0.0512 0.0512
Brugia malayi G protein-coupled receptor 0.0035 0.0512 0.0835
Echinococcus granulosus sex peptide receptor 0.0035 0.0512 0.0512
Onchocerca volvulus Ribonuclease H1 homolog 0.0067 0.1135 0.1608
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0025 0.0303 0.0494
Brugia malayi neuropeptide F receptor 0.0035 0.0512 0.0835
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0035 0.0512 0.0512
Echinococcus multilocularis fmrfamide receptor 0.0035 0.0512 0.0512
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.001 0.0012 0.0012
Schistosoma mansoni regulator of G protein signaling 0.0015 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Echinococcus granulosus neuropeptide FF receptor 2 0.0035 0.0512 0.0512
Brugia malayi PAS domain containing protein 0.0037 0.0542 0.0885
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0071 0.1199 0.1199
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0015 0.0123 0.0123
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0013 0.0087 0.0142
Brugia malayi hypoxia-induced factor 1 0.0114 0.2045 0.3337
Brugia malayi G-protein coupled receptor 0.0035 0.0512 0.0835
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Brugia malayi hypothetical protein 0.0035 0.0512 0.0835
Brugia malayi RNase H family protein 0.0067 0.1135 0.1852
Brugia malayi Dopamine receptor protein 2 0.0035 0.0512 0.0835
Brugia malayi Dopamine receptor 0.0035 0.0512 0.0835
Schistosoma mansoni neuropeptide F-like receptor 0.0035 0.0512 0.0512
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.001 0.0012 0.0019
Echinococcus granulosus lamin dm0 0.0046 0.0717 0.0717
Entamoeba histolytica adenosylhomocysteinase, putative 0.0134 0.2436 1
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0013 0.0087 0.0087
Schistosoma mansoni amine GPCR 0.0035 0.0512 0.0512
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0035 0.0512 0.0512
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0035 0.0512 0.0512
Echinococcus multilocularis inositol monophosphatase 1 0.0028 0.037 0.037
Brugia malayi GH09647p 0.0027 0.0352 0.0574
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0015 0.0123 0.0123
Echinococcus granulosus tachykinin peptides receptor 99D 0.0035 0.0512 0.0512
Echinococcus granulosus biogenic amine 5HT receptor 0.0035 0.0512 0.0512
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0729 0.0729
Schistosoma mansoni poly(p)/ATP NAD kinase 0.0027 0.0352 0.0352
Echinococcus multilocularis Polycystic kidney disease protein 0.0016 0.0132 0.0132
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0035 0.0512 0.0512
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0028 0.037 0.1518
Loa Loa (eye worm) hypothetical protein 0.0015 0.0123 0.0201
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0134 0.2436 0.348
Schistosoma mansoni lipoxygenase 0.0016 0.0132 0.0132
Brugia malayi Serotonin receptor 0.0035 0.0512 0.0835
Echinococcus granulosus lipoxygenase domain containing protein 0.0016 0.0132 0.0132
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0035 0.0512 0.0512
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0035 0.0512 0.0512
Schistosoma mansoni adenosylhomocysteinase 0.0083 0.1441 0.1441
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.001 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0035 0.0512 0.0512
Loa Loa (eye worm) TYRA-2 protein 0.0035 0.0512 0.0835
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.001 0.0012 0.0017
Schistosoma mansoni growth hormone secretagogue receptor 0.0035 0.0512 0.0512
Brugia malayi RE15519p 0.0035 0.0512 0.0835
Brugia malayi bHLH-PAS transcription factor 0.0027 0.0356 0.0581
Echinococcus granulosus ras GTP exchange factor 0.001 0.0012 0.0012
Toxoplasma gondii ribonuclease HI protein 0.0067 0.1135 0.4661
Loa Loa (eye worm) hypothetical protein 0.0223 0.4157 0.6785
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0035 0.0512 0.0512
Trypanosoma cruzi GMP reductase 0.0071 0.1199 0.4923
Echinococcus multilocularis G protein coupled receptor 139 0.0035 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0046 0.0717 0.117
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.001 0.0012 0.0017
Loa Loa (eye worm) PXA domain-containing protein 0.0015 0.0123 0.0201
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0035 0.0512 0.0512
Onchocerca volvulus 0.0035 0.0512 0.0716
Trichomonas vaginalis adenylate cyclase, putative 0.001 0.0012 0.0017
Onchocerca volvulus 0.0035 0.0512 0.0716
Echinococcus multilocularis dro:myosuppressin receptor 0.0035 0.0512 0.0512
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0021 0.0239 0.039
Onchocerca volvulus Putative GMP reductase 0.0029 0.0396 0.055
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0013 0.0087 0.0108
Echinococcus multilocularis musashi 0.0046 0.0717 0.0717
Mycobacterium tuberculosis Inorganic polyphosphate/ATP-NAD kinase PpnK (poly(P)/ATP NAD kinase) 0.0304 0.573 1
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.0134 0.2436 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0255 0.0417
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0028 0.037 0.0215
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0512 0.0512
Giardia lamblia Ribonuclease H 0.0067 0.1135 0.1814
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0126 0.0126
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0729 0.0729
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Loa Loa (eye worm) doublecortin family protein 0.0016 0.0132 0.0215
Schistosoma mansoni intermediate filament proteins 0.0046 0.0717 0.0717
Echinococcus granulosus neuropeptide receptor A26 0.0384 0.7295 0.7295
Echinococcus multilocularis survival motor neuron protein 1 0.0223 0.4157 0.4157
Brugia malayi hypothetical protein 0.0015 0.0123 0.0201
Schistosoma mansoni regulator of G protein signaling 0.0029 0.0385 0.0385
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Echinococcus multilocularis neuropeptide s receptor 0.0384 0.7295 0.7295
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0126 0.0126
Onchocerca volvulus 0.0035 0.0512 0.0716
Echinococcus multilocularis allatostatin A receptor 0.0035 0.0512 0.0512
Echinococcus granulosus G protein coupled receptor 139 0.0035 0.0512 0.0512
Onchocerca volvulus NAD kinase 2, mitochondrial homolog 0.0027 0.0352 0.0487
Loa Loa (eye worm) hypothetical protein 0.0016 0.0132 0.0215
Echinococcus multilocularis ras GTP exchange factor 0.001 0.0012 0.0012
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0022 0.0255 0.0255
Echinococcus granulosus single minded 2 0.0027 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0029 0.0396 0.0646
Brugia malayi PXA domain containing protein 0.0015 0.0123 0.0201
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0035 0.0512 0.0512
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0035 0.0512 0.0835
Brugia malayi PXA domain containing protein 0.0015 0.0123 0.0201
Loa Loa (eye worm) RasGEF domain-containing protein 0.001 0.0012 0.002
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0035 0.0512 0.0835
Trichomonas vaginalis poly(p)/ATP NAD kinase, putative 0.0027 0.0352 0.0502
Trypanosoma cruzi poly(p)/ATP NAD kinase, putative 0.0027 0.0352 0.1443
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0074 0.1262 0.1262
Brugia malayi RasGEF domain containing protein 0.001 0.0012 0.002
Brugia malayi hypothetical protein 0.0013 0.0087 0.0142
Echinococcus granulosus allatostatin A receptor 0.0035 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0035 0.0512 0.0835
Brugia malayi hypothetical protein 0.0016 0.0132 0.0215
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.001 0.0015 0.0061
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0028 0.037 0.0528
Brugia malayi hypothetical protein 0.0124 0.2232 0.3642
Trypanosoma cruzi guanine nucleotide releasing protein, putative 0.001 0.0012 0.0049
Loa Loa (eye worm) hypothetical protein 0.0015 0.0123 0.0201
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0035 0.0512 0.0512
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0123 0.0176
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0512 0.0512
Schistosoma mansoni polycystin 1-related 0.0016 0.0132 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0012 0.0017
Echinococcus granulosus somatostatin receptor 0.0035 0.0512 0.0512
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0324 0.6128 1
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.001 0.0012 0.0012
Onchocerca volvulus 0.0046 0.0717 0.1009
Schistosoma mansoni phosphoglucomutase 0.0067 0.1135 0.1135
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0074 0.1262 0.1262
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0035 0.0512 0.0835
Schistosoma mansoni opsin-like receptor 0.0035 0.0512 0.0512
Toxoplasma gondii hypothetical protein 0.0013 0.0087 0.0358
Trichomonas vaginalis serine threonine-protein kinase, putative 0.0027 0.0353 0.0504
Trypanosoma brucei ingi protein (ORF1) 0.0073 0.1246 0.2631
Leishmania major S-adenosylhomocysteine hydrolase 0.0134 0.2436 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0087 0.0142
Trichomonas vaginalis inositol monophosphatase, putative 0.0028 0.037 0.0528
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0045 0.0701 0.1143
Schistosoma mansoni neuropeptide f receptor 76f 0.0035 0.0512 0.0512
Brugia malayi ORL1-like opioid receptor 0.0035 0.0512 0.0835
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0035 0.0512 0.0512
Schistosoma mansoni adenosylhomocysteinase 0.0134 0.2436 0.2436
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0071 0.1199 0.4923
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0037 0.0547 0.0935
Brugia malayi hypothetical protein 0.0035 0.0512 0.0835
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0015 0.0123 0.0176
Echinococcus granulosus ribonuclease H1 0.0067 0.1135 0.1135
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0071 0.1199 0.2531
Schistosoma mansoni myosin xvIII 0.0035 0.0512 0.0512
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0512 0.0512
Trypanosoma cruzi inorganic polyphosphate/ATP-NAD kinase, putative 0.0027 0.0352 0.1443
Trypanosoma brucei ribonuclease H1 0.0067 0.1135 0.2396
Onchocerca volvulus 0.0035 0.0512 0.0716
Trypanosoma cruzi ribonuclease H1, putative 0.0067 0.1135 0.4661
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0045 0.0696 0.0696
Onchocerca volvulus 0.0035 0.0512 0.0716
Echinococcus multilocularis lipoxygenase domain containing protein 0.0016 0.0132 0.0132
Brugia malayi hypothetical protein 0.0035 0.0512 0.0835
Brugia malayi regulator of G-protein signaling rgs-7 0.0015 0.0123 0.0201
Onchocerca volvulus 0.0035 0.0512 0.0716
Loa Loa (eye worm) melatonin receptor type 1A 0.0035 0.0512 0.0835

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 605 nM Agonist activity at adenosine A1 receptor (unknown origin) assessed as inhibition of isoproterenol-stimulated cAMP accumulation in DDT1MF-2 cells ChEMBL. 18042389
IC50 (functional) = 605 nM Agonist activity at adenosine A1 receptor (unknown origin) assessed as inhibition of isoproterenol-stimulated cAMP accumulation in DDT1MF-2 cells ChEMBL. 18042389
Intrinsic activity (functional) = 0.97 Intrinsic activity at adenosine A1 receptor (unknown origin) assessed as maximal inhibition of isoproterenol-stimulated cAMP accumulation in DDT1MF-2 cells relative to CPA ChEMBL. 18042389
Intrinsic activity (functional) = 0.97 Intrinsic activity at adenosine A1 receptor (unknown origin) assessed as maximal inhibition of isoproterenol-stimulated cAMP accumulation in DDT1MF-2 cells relative to CPA ChEMBL. 18042389
Ki (binding) = 5865 nM Displacement of [3H]CPX from adenosine A1 receptor (unknown origin) in DDT1MF-2 cells ChEMBL. 18042389
Ki (binding) = 5865 nM Displacement of [3H]CPX from adenosine A1 receptor (unknown origin) in DDT1MF-2 cells ChEMBL. 18042389
Ratio (binding) = 1.3 Ratio of Ki to IC50 for adenosine A1 receptor (unknown origin) ChEMBL. 18042389
Ratio (binding) = 1.3 Ratio of Ki to IC50 for adenosine A1 receptor (unknown origin) ChEMBL. 18042389

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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