TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 419.9 | Formula: C20H19ClFN3O2S
H donors: 1 H acceptors: 1 LogP: 4.13 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccc(cc1)NC(=O)Cc1cs/c(=N\c2ccc(c(c2)Cl)F)/n1C
InChi: 1S/C20H19ClFN3O2S/c1-3-27-16-7-4-13(5-8-16)23-19(26)11-15-12-28-20(25(15)2)24-14-6-9-18(22)17(21)10-14/h4-10,12H,3,11H2,1-2H3,(H,23,26)/b24-20-
InChiKey: HPJJLHYWWFUEGX-GFMRDNFCSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0009	0.0031	0.005
Entamoeba histolytica	type A flavoprotein, putative	0.0016	0.0087	0.3295
Schistosoma mansoni	ferritin	0.0008	0.0027	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.005
Schistosoma mansoni	zinc phosphodiesterase	0.0016	0.0087	0.0271
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0007	0.0017	0.0053
Entamoeba histolytica	alkyl sulfatase, putative	0.0016	0.0087	0.3295
Brugia malayi	metallo-beta-lactamase superfamily protein	0.0016	0.0087	0.0257
Trypanosoma cruzi	metallo-beta-lactamase superfamily, putative	0.0016	0.0087	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.005
Onchocerca volvulus		0.0009	0.0031	0.0404
Schistosoma mansoni	hypothetical protein	0.0007	0.0017	0.0053
Onchocerca volvulus		0.0009	0.0031	0.0404
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0016	0.0087	0.006
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.001	0.0039	0.0022
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0009	0.0031	0.0014
Leishmania major	hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative	0.0016	0.0087	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0007	0.0017	0.0053
Echinococcus multilocularis	tar DNA binding protein	0.0067	0.0498	0.0482
Mycobacterium ulcerans	hypothetical protein	0.0016	0.0087	0.006
Brugia malayi	hypothetical protein	0.0038	0.0265	0.0905
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.005
Schistosoma mansoni	hypothetical protein	0.0016	0.0086	0.0265
Schistosoma mansoni	hypothetical protein	0.0007	0.0017	0.0053
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0021	0.0128	1
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0009	0.0031	0.0095
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0232	0.0784
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.0265	0.0249
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0013	0.0062	0.5548
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0039	0.008
Entamoeba histolytica	metallo-beta-lactamase superfamily protein	0.0016	0.0087	0.3295
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0031	0.005
Schistosoma mansoni	neuropeptide F-like receptor	0.0007	0.0017	0.0053
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0009	0.0031	0.005
Mycobacterium ulcerans	Zn-dependent glyoxylase	0.0016	0.0087	0.006
Onchocerca volvulus		0.0009	0.0031	0.0404
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0007	0.0017	0.0053
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0087	0.1731
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0009	0.0031	0.005
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0016	0.0087	0.006
Schistosoma mansoni	zinc phosphodiesterase	0.0016	0.0087	0.0271
Onchocerca volvulus		0.0009	0.0031	0.0404
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0009	0.0031	0.005
Mycobacterium leprae	POSSIBLE HYDROLASE	0.0016	0.0087	0.0217
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0009	0.0031	0.1155
Schistosoma mansoni	neuropeptide receptor	0.0007	0.0017	0.0053
Mycobacterium ulcerans	hydrolase	0.0016	0.0087	0.006
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0007	0.0017	0.0053
Schistosoma mansoni	neuropeptide receptor	0.0007	0.0017	0.0053
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0012	0.00000000074633
Schistosoma mansoni	blooms syndrome DNA helicase	0.0019	0.0111	0.0344
Leishmania major	hypothetical protein, conserved	0.0016	0.0087	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0009	0.0031	0.0014
Mycobacterium leprae	conserved hypothetical protein	0.0016	0.0087	0.0217
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0009	0.0031	0.0014
Giardia lamblia	Hydroxyacylglutathione hydrolase	0.0016	0.0087	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0087	0.0257
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0054	0.0394	1
Onchocerca volvulus		0.0016	0.0087	0.2084
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0346	0.276	0.2748
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0087	0.1731
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0007	0.0017	0.0053
Brugia malayi	Protein-tyrosine phosphatase 1	0.0009	0.0031	0.005
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0009	0.0031	0.005
Trypanosoma brucei	glyoxalase II	0.0016	0.0087	1
Mycobacterium ulcerans	hypothetical protein	0.0016	0.0087	0.006
Schistosoma mansoni	opsin-like receptor	0.0007	0.0017	0.0053
Plasmodium falciparum	cytosolic glyoxalase II	0.0016	0.0087	0.5435
Schistosoma mansoni	ferritin light chain	0.0008	0.0027	0.0085
Leishmania major	metallo-beta-lactamase family protein-like protein	0.0016	0.0087	1
Onchocerca volvulus		0.0049	0.0355	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0012	0.00000000074633
Mycobacterium tuberculosis	Conserved protein	0.0016	0.0087	0.006
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0346	0.276	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0086	0.025
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0009	0.0031	0.0095
Schistosoma mansoni	hypothetical protein	0.0016	0.0086	0.0265
Onchocerca volvulus		0.0009	0.0031	0.0404
Mycobacterium ulcerans	glyoxalase II, GloB	0.0016	0.0087	0.006
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0009	0.0031	0.0095
Onchocerca volvulus		0.0009	0.0031	0.0404
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0009	0.0031	0.005
Schistosoma mansoni	cpg binding protein	0.003	0.0202	0.0626
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0009	0.0031	0.0095
Onchocerca volvulus		0.0009	0.0031	0.0404
Echinococcus multilocularis	hypothetical protein	0.0009	0.0031	0.0014
Trypanosoma cruzi	glyoxalase II	0.0016	0.0087	1
Trypanosoma cruzi	metallo-beta-lactamase-like protein, putative	0.0016	0.0087	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0346	0.276	1
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0346	0.276	0.855
Schistosoma mansoni	protein tyrosine phosphatase	0.0009	0.0031	0.0095
Onchocerca volvulus	Putative hydrolase PNKD	0.0016	0.0087	0.2084
Brugia malayi	RNA recognition motif domain containing protein	0.0067	0.0498	0.1752
Echinococcus multilocularis	ferritin	0.0008	0.0027	0.0011
Schistosoma mansoni	hypothetical protein	0.0016	0.0087	0.0271
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0009	0.0031	0.0014
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0087	0.1731
Trichomonas vaginalis	protein kinase inhibitor, putative	0.0061	0.0449	1
Trypanosoma cruzi	metallo-beta-lactamase superfamily, putative	0.0016	0.0087	1
Leishmania major	cleavage and polyadenylation specificity factor, putative	0.0016	0.0087	1
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0039	0.0984
Onchocerca volvulus		0.0009	0.0031	0.0404
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0009	0.0031	0.005
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0007	0.0017	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0232	0.0784
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0009	0.0031	0.005
Schistosoma mansoni	ferritin	0.0008	0.0027	0.0085
Onchocerca volvulus		0.0009	0.0031	0.0404
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0009	0.0031	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0087	0.0257
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0009	0.0031	0.0014
Mycobacterium tuberculosis	Beta lactamase like protein	0.0016	0.0087	0.006
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0007	0.0017	0.0053
Echinococcus multilocularis	zinc phosphodiesterase	0.0016	0.0087	0.0071
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0009	0.0031	0.0014
Brugia malayi	hypothetical protein	0.0009	0.0031	0.005
Echinococcus granulosus	cpg binding protein	0.003	0.0202	0.0186
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0007	0.0017	0.0053
Schistosoma mansoni	hypothetical protein	0.0007	0.0017	0.0053
Trypanosoma cruzi	metallo-beta-lactamase-like protein, putative	0.0016	0.0087	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0009	0.0031	0.0014
Trichomonas vaginalis	beta lactamase domain, putative	0.0016	0.0087	0.1731
Brugia malayi	ethe1-prov protein	0.0016	0.0087	0.0257
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0009	0.0031	0.0014
Echinococcus multilocularis	metallo beta lactamase domain containing protein	0.0016	0.0087	0.0071
Onchocerca volvulus		0.0028	0.0189	0.5095
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0007	0.0017	0.0053
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0007	0.0017	0.0053
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0009	0.0031	0.0014
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0007	0.0017	0.0053
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0009	0.0031	0.005
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0007	0.0017	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.005
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.005
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0009	0.0031	0.1155
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0009	0.0031	0.0014
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0009	0.0031	0.005
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.005
Schistosoma mansoni	neuropeptide F-like receptor	0.0007	0.0017	0.0053
Trichomonas vaginalis	beta lactamase domain, putative	0.0016	0.0087	0.1731
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0087	0.1731
Toxoplasma gondii	hydroxyacylglutathione hydrolase	0.0016	0.0087	0.2216
Brugia malayi	hypothetical protein	0.0009	0.0031	0.005
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0009	0.0031	0.005
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.001	0.0039	0.008
Schistosoma mansoni	hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II)	0.0016	0.0087	0.0271
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0009	0.0031	0.0014
Mycobacterium tuberculosis	Conserved protein	0.0016	0.0087	0.006
Schistosoma mansoni	DNA helicase recq5	0.001	0.0039	0.012
Schistosoma mansoni	amine GPCR	0.0007	0.0017	0.0053
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0013	0.0062	0.5548
Onchocerca volvulus	Hydroxyacylglutathione hydrolase, mitochondrial homolog	0.0016	0.0087	0.2084
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.005
Onchocerca volvulus		0.0009	0.0031	0.0404
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.0265	0.0249
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0009	0.0031	0.005
Schistosoma mansoni	neuropeptide receptor	0.0007	0.0017	0.0053
Toxoplasma gondii	metallo-beta-lactamase domain-containing protein	0.0016	0.0087	0.2216
Mycobacterium leprae	Beta-lactamase-like protein	0.0016	0.0087	0.0217
Schistosoma mansoni	hypothetical protein	0.0016	0.0087	0.0271
Onchocerca volvulus	4.1 G protein, putative homolog	0.0009	0.0031	0.0404
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0067	0.0498	0.1752
Echinococcus granulosus	tar DNA binding protein	0.0067	0.0498	0.0482
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0007	0.0017	0.0053
Mycobacterium ulcerans	hydrolase	0.0016	0.0087	0.006
Schistosoma mansoni	DNA helicase recq1	0.001	0.0039	0.012
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.005
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0346	0.276	0.2748
Entamoeba histolytica	hypothetical protein	0.0038	0.0265	1
Onchocerca volvulus		0.0009	0.0031	0.0404
Entamoeba histolytica	metallo-beta-lactamase family protein	0.0016	0.0087	0.3295
Trichomonas vaginalis	ferritin, putative	0.0008	0.0027	0.036
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.005
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0498	0.1542
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0009	0.0031	0.0095
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0009	0.0031	0.005
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.005
Brugia malayi	TAR-binding protein	0.0067	0.0498	0.1752
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0009	0.0031	0.0014
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0009	0.0031	0.0014
Schistosoma mansoni	hypothetical protein	0.0016	0.0086	0.0265
Mycobacterium ulcerans	thymidine phosphorylase	0.1241	1	1
Brugia malayi	RNA binding protein	0.0067	0.0498	0.1752
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0009	0.0031	0.0014
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.0265	0.0821
Schistosoma mansoni	hypothetical protein	0.0007	0.0017	0.0053
Trichomonas vaginalis	DNA helicase recq1, putative	0.0024	0.0151	0.3196
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.005
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0009	0.0031	0.005
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0007	0.0017	0.0053
Giardia lamblia	Sgs1 DNA helicase, putative	0.001	0.0039	0.1442
Brugia malayi	Bloom's syndrome protein homolog	0.0024	0.0151	0.049
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0009	0.0031	0.0014
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0007	0.0017	0.0053
Echinococcus granulosus	ferritin	0.0008	0.0027	0.0011
Trypanosoma brucei	metallo-beta-lactamase-like protein, putative	0.0016	0.0087	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.005
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0009	0.0031	0.005
Trypanosoma cruzi	glyoxalase II	0.0016	0.0087	1
Entamoeba histolytica	metallo-beta-lactamase family protein	0.0016	0.0087	0.3295
Loa Loa (eye worm)	hydroxyacylglutathione hydrolase	0.0016	0.0087	0.0257
Schistosoma mansoni	ferritin	0.0008	0.0027	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.005
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0087	0.0257
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0013	0.0062	0.5548
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.005
Schistosoma mansoni	myosin xvIII	0.0007	0.0017	0.0053
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0009	0.0031	0.005
Trichomonas vaginalis	apoptosis inducing factor, putative	0.0016	0.0087	0.1731
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0009	0.0031	0.0014
Trichomonas vaginalis	DNA helicase recq, putative	0.0024	0.0151	0.3196
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.005
Entamoeba histolytica	metallo-beta-lactamase family protein	0.0016	0.0087	0.3295
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.005
Loa Loa (eye worm)	hydroxyacylglutathione hydrolase cytoplasmic	0.0016	0.0087	0.0257
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0086	0.025
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0007	0.0017	0.0053
Onchocerca volvulus		0.0009	0.0031	0.0404
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0086	0.0069
Mycobacterium tuberculosis	Possible hydrolase	0.0016	0.0087	0.006
Onchocerca volvulus		0.0009	0.0031	0.0404
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0009	0.0031	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0355	0.1232
Trichomonas vaginalis	beta lactamase domain, putative	0.0016	0.0087	0.1731
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0086	0.0069
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0087	0.1731
Schistosoma mansoni	neuropeptide f receptor 76f	0.0007	0.0017	0.0053
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0009	0.0031	0.005
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0009	0.0031	0.0014
Trichomonas vaginalis	pten, drome, putative	0.0009	0.0031	0.0434
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0009	0.0031	0.005
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0009	0.0031	0.0095
Entamoeba histolytica	type A flavoprotein, putative	0.0016	0.0087	0.3295
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0016	0.0087	0.006
Echinococcus granulosus	bloom syndrome protein	0.0024	0.0151	0.0135
Trichomonas vaginalis	A-type flavoprotein	0.0016	0.0087	0.1731
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0009	0.0031	0.0095
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.006	0.0446	0.1383
Mycobacterium tuberculosis	Possible hydrolase	0.0016	0.0087	0.006
Schistosoma mansoni	apoferritin-2	0.0008	0.0027	0.0085
Wolbachia endosymbiont of Brugia malayi	metallo-beta-lactamase superfamily hydrolase	0.0016	0.0087	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0009	0.0031	0.005
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0009	0.0031	0.005
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0009	0.0031	0.0014
Mycobacterium ulcerans	hydrolase	0.0016	0.0087	0.006
Echinococcus granulosus	tumor protein p63	0.0334	0.266	0.2648
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0012	0.00000000074633
Onchocerca volvulus		0.0009	0.0031	0.0404
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0087	0.1731
Schistosoma mansoni	ferritin light chain	0.0008	0.0027	0.0085
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0017	0.0052
Loa Loa (eye worm)	RecQ helicase	0.0024	0.0151	0.049
Entamoeba histolytica	hypothetical protein	0.0038	0.0265	1
Schistosoma mansoni	opsin-like receptor	0.0007	0.0017	0.0053
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0009	0.0031	0.0014
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0009	0.0031	0.0014
Schistosoma mansoni	hypothetical protein	0.0061	0.0449	0.1391
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.003	0.0046
Brugia malayi	hypothetical protein	0.0009	0.0031	0.005
Mycobacterium ulcerans	hypothetical protein	0.0016	0.0087	0.006
Echinococcus multilocularis	ETHE1 protein	0.0016	0.0087	0.0071
Schistosoma mansoni	ferritin	0.0008	0.0027	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.005
Schistosoma mansoni	hypothetical protein	0.0038	0.0265	0.0821
Mycobacterium leprae	conserved hypothetical protein	0.0016	0.0087	0.0217
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0007	0.0017	0.0053
Brugia malayi	Protein-tyrosine phosphatase	0.0009	0.0031	0.005
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0925	0.3311
Trichomonas vaginalis	DNA helicase recq, putative	0.0013	0.0062	0.1154
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0009	0.0031	0.0095
Loa Loa (eye worm)	hypothetical protein	0.001	0.0039	0.008
Mycobacterium leprae	Probable anthranilate phosphoribosyltransferase TrpD	0.035	0.2794	1
Echinococcus granulosus	metallo beta lactamase domain containing protein	0.0016	0.0087	0.0071
Trichomonas vaginalis	beta lactamase domain, putative	0.0016	0.0087	0.1731
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0009	0.0031	0.0014
Onchocerca volvulus		0.0016	0.0087	0.2084
Giardia lamblia	Hydroxyacylglutathione hydrolase	0.0016	0.0087	1
Schistosoma mansoni	protein tyrosine phosphatase	0.0009	0.0031	0.0095
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0009	0.0031	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.005
Echinococcus multilocularis		0.0009	0.0031	0.0014
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0009	0.0031	0.005
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0009	0.0031	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0358	0.1243
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0009	0.0031	0.0014
Echinococcus granulosus	metallo beta lactamase domain containing protein	0.0016	0.0087	0.0071
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0039	0.0984
Entamoeba histolytica	hypothetical protein	0.0038	0.0265	1
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0498	0.1542
Entamoeba histolytica	alkyl sulfatase, putative	0.0016	0.0087	0.3295
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0086	0.025
Trichomonas vaginalis	beta lactamase domain, putative	0.0016	0.0087	0.1731
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0009	0.0031	0.0095
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0009	0.0031	0.0014
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0009	0.0031	0.0014
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0086	0.0069
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0009	0.0031	0.0014
Chlamydia trachomatis	ribonuclease Z	0.0016	0.0087	0.5
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0007	0.0017	0.0053
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0009	0.0031	0.005
Trypanosoma cruzi	hydroxyacylglutathione hydrolase, putative	0.0016	0.0087	1
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0009	0.0031	0.0095
Echinococcus granulosus	GPCR family 2	0.0016	0.0086	0.0069
Schistosoma mansoni	biogenic amine receptor	0.0007	0.0017	0.0053
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0031	0.0014
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0009	0.0031	0.0014
Echinococcus granulosus	zinc phosphodiesterase	0.0016	0.0087	0.0071
Onchocerca volvulus		0.0009	0.0031	0.0404
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0009	0.0031	0.0014
Schistosoma mansoni	pcd6 interacting protein-related	0.0009	0.0031	0.0095
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0086	0.0069
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0012	0.00000000074633
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0086	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.005
Schistosoma mansoni	hypothetical protein	0.0016	0.0086	0.0265
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.0012	0.00000000074633
Treponema pallidum	bacterioferrin (TpF1)	0.0008	0.0027	0.3134
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0087	0.0257
Schistosoma mansoni	neuropeptide receptor	0.0007	0.0017	0.0053
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0009	0.0031	0.005
Schistosoma mansoni	opsin-like receptor	0.0007	0.0017	0.0053
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.001	0.0039	0.0022
Giardia lamblia	Metallo-beta-lactamase superfamily protein	0.0016	0.0087	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0009	0.0031	0.0014
Echinococcus granulosus	ETHE1 protein	0.0016	0.0087	0.0071
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0009	0.0031	0.0095
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0009	0.0031	0.005
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0009	0.0031	0.005
Brugia malayi	hypothetical protein	0.0016	0.0087	0.0257
Schistosoma mansoni	biogenic amine receptor	0.0007	0.0017	0.0053
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0009	0.0031	0.0014
Mycobacterium ulcerans	hypothetical protein	0.0016	0.0087	0.006
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.001	0.0039	0.0022
Echinococcus multilocularis	thymidine phosphorylase	0.1241	1	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0009	0.0031	0.0014
Loa Loa (eye worm)	TAR-binding protein	0.0067	0.0498	0.1752
Echinococcus multilocularis	dnaJ subfamily C 6	0.0061	0.0449	0.0433
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0358	0.1243
Onchocerca volvulus		0.0009	0.0031	0.0404
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0016	0.0088	0.2226
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0009	0.0031	0.0014
Brugia malayi	DnaJ domain containing protein	0.0061	0.0449	0.1575
Schistosoma mansoni	amine GPCR	0.0007	0.0017	0.0053
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0012	0.00000000074633
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0009	0.0031	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.005
Echinococcus granulosus	expressed protein	0.0008	0.0027	0.0011
Schistosoma mansoni	cellular tumor antigen P53	0.0049	0.0355	0.1099
Schistosoma mansoni	hypothetical protein	0.0404	0.3228	1
Echinococcus granulosus	dnaJ subfamily C 6	0.0061	0.0449	0.0433
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0007	0.0017	0.0053
Mycobacterium ulcerans	beta lactamase-like protein	0.0016	0.0087	0.006
Echinococcus multilocularis	tumor protein p63	0.0334	0.266	0.2648
Trypanosoma brucei	hydroxyacylglutathione hydrolase, putative	0.0016	0.0087	1
Onchocerca volvulus		0.0009	0.0031	0.0404
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0009	0.0031	0.005
Entamoeba histolytica	hypothetical protein, conserved	0.0016	0.0087	0.3295
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.005
Mycobacterium ulcerans	anthranilate phosphoribosyltransferase	0.035	0.2794	0.2774
Echinococcus multilocularis	metallo beta lactamase domain containing protein	0.0016	0.0087	0.0071
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0009	0.0031	0.005
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0009	0.0031	0.1155
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0039	0.008
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0009	0.0031	0.0014
Schistosoma mansoni	protein tyrosine phosphatase	0.0009	0.0031	0.0095
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0009	0.0031	0.005
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.0012	0.00000000074633
Mycobacterium tuberculosis	Probable anthranilate phosphoribosyltransferase TrpD	0.035	0.2794	0.2774
Brugia malayi	hypothetical protein	0.0009	0.0031	0.005
Mycobacterium tuberculosis	Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase)	0.1241	1	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0007	0.0017	0.0053
Schistosoma mansoni	cpg binding protein	0.0028	0.0189	0.0586
Echinococcus granulosus	dnaJ subfamily B	0.0404	0.3228	0.3217
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0009	0.0031	0.005
Leishmania major	metallo-beta-lactamase family-like protein	0.0016	0.0087	1
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0016	0.0087	0.1731
Loa Loa (eye worm)	metallo-beta-lactamase superfamily protein	0.0016	0.0087	0.0257
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0009	0.0031	0.005
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0009	0.0031	0.005
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0009	0.0031	0.0095
Onchocerca volvulus		0.0009	0.0031	0.0404
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0009	0.0031	0.005
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0007	0.0017	0.0053
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0009	0.0031	0.005
Schistosoma mansoni	biogenic amine receptor	0.0007	0.0017	0.0053
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0009	0.0031	0.005
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0009	0.0031	0.005
Trypanosoma brucei	cleavage and polyadenylation specificity factor subunit, putative	0.0016	0.0087	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0031	0.0014
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0009	0.0031	0.0014
Entamoeba histolytica	recQ family helicase, putative	0.0013	0.0062	0.2343
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.005
Onchocerca volvulus		0.0009	0.0031	0.0404
Brugia malayi	metallo-beta-lactamase superfamily protein	0.0016	0.0087	0.0257
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0009	0.0031	0.005
Onchocerca volvulus		0.0009	0.0031	0.0404
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0009	0.0031	0.005
Brugia malayi	Protein-tyrosine phosphatase	0.0009	0.0031	0.005
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0498	0.1542
Schistosoma mansoni	growth hormone secretagogue receptor	0.0007	0.0017	0.0053
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0009	0.0031	0.0014
Treponema pallidum	ribonuclease Z	0.0016	0.0087	1
Echinococcus multilocularis	hydroxyacylglutathione hydrolase	0.0016	0.0087	0.0071
Mycobacterium tuberculosis	Conserved protein	0.0016	0.0087	0.006
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0358	0.1243
Onchocerca volvulus		0.0009	0.0031	0.0404
Echinococcus multilocularis	bloom syndrome protein	0.0024	0.0151	0.0135
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0358	0.1243
Loa Loa (eye worm)	RNA binding protein	0.0067	0.0498	0.1752
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.001	0.0039	0.0022
Trichomonas vaginalis	beta lactamase domain, putative	0.0016	0.0087	0.1731
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0009	0.0031	0.005
Schistosoma mansoni	cpg binding protein	0.003	0.0202	0.0626
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0007	0.0017	0.0053
Schistosoma mansoni	amine GPCR	0.0007	0.0017	0.0053
Trypanosoma cruzi	glyoxalase II	0.0016	0.0087	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0009	0.0031	0.005
Entamoeba histolytica	hypothetical protein	0.0038	0.0265	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.005
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0498	0.1542
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0016	0.0089	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0012	0.00000000074633
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0189	0.0628
Echinococcus multilocularis	cpg binding protein	0.003	0.0202	0.0186
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0189	0.0628
Schistosoma mansoni	hypothetical protein	0.0034	0.0232	0.0719
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0086	0.025
Schistosoma mansoni	amine GPCR	0.0007	0.0017	0.0053
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0009	0.0031	0.005
Entamoeba histolytica	metallo-beta-lactamase superfamily protein	0.0016	0.0087	0.3295
Onchocerca volvulus		0.0009	0.0031	0.0404
Brugia malayi	hypothetical protein	0.0009	0.0031	0.005
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0009	0.0031	0.005
Echinococcus multilocularis	dnaJ subfamily B	0.0404	0.3228	0.3217
Loa Loa (eye worm)	DnaJ domain-containing protein	0.0061	0.0449	0.1575
Schistosoma mansoni	apoferritin-2	0.0008	0.0027	0.0085
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0009	0.0031	0.0014
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0009	0.0031	0.005
Echinococcus granulosus	hydroxyacylglutathione hydrolase	0.0016	0.0087	0.0071
Echinococcus multilocularis	expressed protein	0.0008	0.0027	0.0011
Schistosoma mansoni	amine GPCR	0.0007	0.0017	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.005
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0009	0.0031	0.005
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.005
Schistosoma mansoni	hypothetical protein	0.0016	0.0087	0.0271
Onchocerca volvulus		0.0009	0.0031	0.0404
Brugia malayi	Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site.	0.0016	0.0087	0.0257
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0007	0.0017	0.0053
Schistosoma mansoni	histamine h1 receptor	0.0007	0.0017	0.0053
Trypanosoma cruzi	hydroxyacylglutathione hydrolase, putative	0.0016	0.0087	1
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0498	0.1542
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0009	0.0031	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.005
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0007	0.0017	0.0053
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0007	0.0017	0.0053
Schistosoma mansoni	adenoreceptor	0.0007	0.0017	0.0053

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 1.94	Antifungal activity against Magnaporthe grisea infected rice plant assessed as logarithm of fungal control value at 100 ppm after 5 days	ChEMBL.	18299194

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL256254

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 516755