Detailed information for compound 516755

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 419.9 | Formula: C20H19ClFN3O2S
  • H donors: 1 H acceptors: 1 LogP: 4.13 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)NC(=O)Cc1cs/c(=N\c2ccc(c(c2)Cl)F)/n1C
  • InChi: 1S/C20H19ClFN3O2S/c1-3-27-16-7-4-13(5-8-16)23-19(26)11-15-12-28-20(25(15)2)24-14-6-9-18(22)17(21)10-14/h4-10,12H,3,11H2,1-2H3,(H,23,26)/b24-20-
  • InChiKey: HPJJLHYWWFUEGX-GFMRDNFCSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) RNA binding protein 0.0067 0.0498 0.1752
Loa Loa (eye worm) hypothetical protein 0.0009 0.0031 0.005
Schistosoma mansoni hypothetical protein 0.0016 0.0086 0.0265
Loa Loa (eye worm) metallo-beta-lactamase superfamily protein 0.0016 0.0087 0.0257
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0009 0.0031 0.0014
Schistosoma mansoni ferritin light chain 0.0008 0.0027 0.0085
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0151 0.049
Loa Loa (eye worm) hypothetical protein 0.0049 0.0358 0.1243
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0016 0.0087 0.1731
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0086 0.025
Onchocerca volvulus 0.0009 0.0031 0.0404
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0009 0.0031 0.0014
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0031 0.005
Echinococcus multilocularis dnaJ subfamily B 0.0404 0.3228 0.3217
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0009 0.0031 0.005
Echinococcus granulosus tumor protein p63 0.0334 0.266 0.2648
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0232 0.0784
Echinococcus granulosus ETHE1 protein 0.0016 0.0087 0.0071
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0031 0.005
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0086 0.0069
Mycobacterium ulcerans hypothetical protein 0.0016 0.0087 0.006
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0346 0.276 0.2748
Loa Loa (eye worm) hypothetical protein 0.0009 0.0031 0.005
Loa Loa (eye worm) hypothetical protein 0.0009 0.0031 0.005
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0009 0.0031 0.0014
Trypanosoma cruzi glyoxalase II 0.0016 0.0087 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0031 0.005
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0031 0.0014
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0151 0.0135
Onchocerca volvulus 0.0009 0.0031 0.0404
Brugia malayi metallo-beta-lactamase superfamily protein 0.0016 0.0087 0.0257
Leishmania major cleavage and polyadenylation specificity factor, putative 0.0016 0.0087 1
Leishmania major hypothetical protein, conserved 0.0016 0.0087 1
Echinococcus granulosus cpg binding protein 0.003 0.0202 0.0186
Brugia malayi metallo-beta-lactamase superfamily protein 0.0016 0.0087 0.0257
Onchocerca volvulus 0.0009 0.0031 0.0404
Loa Loa (eye worm) hypothetical protein 0.0009 0.0031 0.005
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0446 0.1383
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0009 0.0031 0.0014
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0009 0.0031 0.005
Loa Loa (eye worm) hypothetical protein 0.0009 0.0031 0.005
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0009 0.0031 0.0095
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0009 0.0031 0.005
Schistosoma mansoni protein tyrosine phosphatase 0.0009 0.0031 0.0095
Schistosoma mansoni biogenic amine receptor 0.0007 0.0017 0.0053
Schistosoma mansoni DNA helicase recq1 0.001 0.0039 0.012
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0009 0.0031 0.0014
Loa Loa (eye worm) hypothetical protein 0.0009 0.0031 0.005
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0498 0.1752
Mycobacterium ulcerans Zn-dependent glyoxylase 0.0016 0.0087 0.006
Onchocerca volvulus 0.0009 0.0031 0.0404
Giardia lamblia Sgs1 DNA helicase, putative 0.001 0.0039 0.1442
Loa Loa (eye worm) protein tyrosine phosphatase 0.0009 0.0031 0.005
Entamoeba histolytica type A flavoprotein, putative 0.0016 0.0087 0.3295
Entamoeba histolytica metallo-beta-lactamase family protein 0.0016 0.0087 0.3295
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0498 0.1542
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0009 0.0031 0.0014
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0009 0.0031 0.0014
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0039 0.008
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0009 0.0031 0.0095
Echinococcus multilocularis expressed protein 0.0008 0.0027 0.0011
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0017 0.0052
Onchocerca volvulus 0.0028 0.0189 0.5095
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0009 0.0031 0.0014
Schistosoma mansoni neuropeptide receptor 0.0007 0.0017 0.0053
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0012 0.00000000074633
Mycobacterium tuberculosis Conserved hypothetical protein 0.0016 0.0087 0.006
Loa Loa (eye worm) hypothetical protein 0.0119 0.0925 0.3311
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0039 0.008
Schistosoma mansoni hypothetical protein 0.0007 0.0017 0.0053
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0009 0.0031 0.0095
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0039 0.008
Loa Loa (eye worm) hypothetical protein 0.0009 0.0031 0.005
Onchocerca volvulus 0.0009 0.0031 0.0404
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0498 0.0482
Onchocerca volvulus 0.0009 0.0031 0.0404
Echinococcus granulosus GPCR family 2 0.0016 0.0086 0.0069
Trichomonas vaginalis ferritin, putative 0.0008 0.0027 0.036
Loa Loa (eye worm) RecQ helicase 0.0024 0.0151 0.049
Schistosoma mansoni amine GPCR 0.0007 0.0017 0.0053
Brugia malayi RNA binding protein 0.0067 0.0498 0.1752
Mycobacterium ulcerans hypothetical protein 0.0016 0.0087 0.006
Schistosoma mansoni ferritin 0.0008 0.0027 0.0085
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0346 0.276 1
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0062 0.1154
Brugia malayi hypothetical protein 0.0009 0.0031 0.005
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0016 0.0087 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0039 0.0984
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0009 0.0031 0.0014
Brugia malayi ethe1-prov protein 0.0016 0.0087 0.0257
Echinococcus multilocularis ETHE1 protein 0.0016 0.0087 0.0071
Loa Loa (eye worm) hypothetical protein 0.0009 0.0031 0.005
Schistosoma mansoni neuropeptide f receptor 76f 0.0007 0.0017 0.0053
Loa Loa (eye worm) hypothetical protein 0.0016 0.0087 0.0257
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0007 0.0017 0.0053
Schistosoma mansoni adenoreceptor 0.0007 0.0017 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0087 0.1731
Trichomonas vaginalis beta lactamase domain, putative 0.0016 0.0087 0.1731
Schistosoma mansoni hypothetical protein 0.0016 0.0086 0.0265
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0087 0.1731
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0031 0.005
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0009 0.0031 0.0095
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0031 0.005
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0007 0.0017 0.0053
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0009 0.0031 0.0014
Onchocerca volvulus Hydroxyacylglutathione hydrolase, mitochondrial homolog 0.0016 0.0087 0.2084
Loa Loa (eye worm) hypothetical protein 0.001 0.0039 0.008
Schistosoma mansoni apoferritin-2 0.0008 0.0027 0.0085
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0031 0.005
Plasmodium falciparum cytosolic glyoxalase II 0.0016 0.0087 0.5435
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0009 0.0031 0.0095
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0012 0.00000000074633
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.003 0.0046
Onchocerca volvulus 0.0009 0.0031 0.0404
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0009 0.0031 0.1155
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0009 0.0031 0.1155
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0017 0.0053
Onchocerca volvulus 4.1 G protein, putative homolog 0.0009 0.0031 0.0404
Schistosoma mansoni opsin-like receptor 0.0007 0.0017 0.0053
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0009 0.0031 0.0095
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0358 0.1243
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0009 0.0031 0.0095
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0012 0.00000000074633
Loa Loa (eye worm) hypothetical protein 0.0009 0.0031 0.005
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0009 0.0031 0.005
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0009 0.0031 0.0014
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0009 0.0031 0.005
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0031 0.005
Trichomonas vaginalis protein kinase inhibitor, putative 0.0061 0.0449 1
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0016 0.0087 1
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0039 0.0022
Schistosoma mansoni hypothetical protein 0.0404 0.3228 1
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0016 0.0087 0.0071
Mycobacterium leprae Beta-lactamase-like protein 0.0016 0.0087 0.0217
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0007 0.0017 0.0053
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0346 0.276 1
Entamoeba histolytica alkyl sulfatase, putative 0.0016 0.0087 0.3295
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0009 0.0031 0.0095
Loa Loa (eye worm) hypothetical protein 0.0034 0.0232 0.0784
Brugia malayi DnaJ domain containing protein 0.0061 0.0449 0.1575
Brugia malayi TAR-binding protein 0.0067 0.0498 0.1752
Loa Loa (eye worm) hypothetical protein 0.0009 0.0031 0.005
Mycobacterium ulcerans beta lactamase-like protein 0.0016 0.0087 0.006
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0009 0.0031 0.0014
Mycobacterium tuberculosis Possible hydrolase 0.0016 0.0087 0.006
Echinococcus granulosus ferritin 0.0008 0.0027 0.0011
Schistosoma mansoni opsin-like receptor 0.0007 0.0017 0.0053
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) 0.1241 1 1
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0009 0.0031 0.0095
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0086 0.0069
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0111 0.0344
Loa Loa (eye worm) hypothetical protein 0.0009 0.0031 0.005
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0009 0.0031 0.0014
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0009 0.0031 0.0095
Loa Loa (eye worm) hypothetical protein 0.0009 0.0031 0.005
Leishmania major metallo-beta-lactamase family protein-like protein 0.0016 0.0087 1
Giardia lamblia Metallo-beta-lactamase superfamily protein 0.0016 0.0087 1
Onchocerca volvulus 0.0016 0.0087 0.2084
Mycobacterium ulcerans glyoxalase II, GloB 0.0016 0.0087 0.006
Schistosoma mansoni biogenic amine (5HT) receptor 0.0007 0.0017 0.0053
Schistosoma mansoni hypothetical protein 0.0016 0.0087 0.0271
Loa Loa (eye worm) hypothetical protein 0.0016 0.0086 0.025
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0346 0.276 0.855
Onchocerca volvulus 0.0009 0.0031 0.0404
Echinococcus multilocularis zinc phosphodiesterase 0.0016 0.0087 0.0071
Brugia malayi hypothetical protein 0.0009 0.0031 0.005
Echinococcus multilocularis GPCR, family 2 0.0016 0.0086 0.0069
Mycobacterium leprae conserved hypothetical protein 0.0016 0.0087 0.0217
Brugia malayi CXXC zinc finger family protein 0.0028 0.0189 0.0628
Schistosoma mansoni amine GPCR 0.0007 0.0017 0.0053
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0031 0.005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0017 0.0053
Mycobacterium tuberculosis Probable anthranilate phosphoribosyltransferase TrpD 0.035 0.2794 0.2774
Trichomonas vaginalis beta lactamase domain, putative 0.0016 0.0087 0.1731
Schistosoma mansoni neuropeptide receptor 0.0007 0.0017 0.0053
Onchocerca volvulus 0.0009 0.0031 0.0404
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0009 0.0031 0.0014
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0009 0.0031 0.0014
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0128 1
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0087 0.1731
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0265 0.0249
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0016 0.0087 1
Schistosoma mansoni cpg binding protein 0.0028 0.0189 0.0586
Schistosoma mansoni hypothetical protein 0.0016 0.0086 0.0265
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0265 0.0821
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0039 0.0984
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0009 0.0031 0.0095
Mycobacterium leprae Probable anthranilate phosphoribosyltransferase TrpD 0.035 0.2794 1
Schistosoma mansoni neuropeptide F-like receptor 0.0007 0.0017 0.0053
Mycobacterium ulcerans hydrolase 0.0016 0.0087 0.006
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0016 0.0087 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0031 0.005
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0031 0.005
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0062 0.5548
Mycobacterium tuberculosis Possible hydrolase 0.0016 0.0087 0.006
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0009 0.0031 0.005
Entamoeba histolytica hypothetical protein 0.0038 0.0265 1
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0498 0.1542
Loa Loa (eye worm) hypothetical protein 0.0009 0.0031 0.005
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0009 0.0031 0.0014
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0009 0.0031 0.0014
Trichomonas vaginalis beta lactamase domain, putative 0.0016 0.0087 0.1731
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0017 0.0053
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0498 0.1542
Onchocerca volvulus 0.0009 0.0031 0.0404
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0031 0.005
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0009 0.0031 0.0014
Onchocerca volvulus 0.0009 0.0031 0.0404
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0087 0.1731
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0007 0.0017 0.0053
Schistosoma mansoni hypothetical protein 0.0038 0.0265 0.0821
Schistosoma mansoni cpg binding protein 0.003 0.0202 0.0626
Onchocerca volvulus 0.0009 0.0031 0.0404
Schistosoma mansoni ferritin 0.0008 0.0027 0.0085
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0009 0.0031 0.0014
Schistosoma mansoni protein tyrosine phosphatase 0.0009 0.0031 0.0095
Loa Loa (eye worm) hypothetical protein 0.0009 0.0031 0.005
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0016 0.0087 1
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0016 0.0087 0.0071
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0009 0.0031 0.005
Mycobacterium tuberculosis Conserved protein 0.0016 0.0087 0.006
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0009 0.0031 0.005
Schistosoma mansoni hypothetical protein 0.0016 0.0087 0.0271
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0498 0.1752
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0498 0.1542
Mycobacterium ulcerans anthranilate phosphoribosyltransferase 0.035 0.2794 0.2774
Schistosoma mansoni hypothetical protein 0.0007 0.0017 0.0053
Loa Loa (eye worm) hypothetical protein 0.0009 0.0031 0.005
Echinococcus granulosus protein tyrosine phosphatase n9 0.0009 0.0031 0.0014
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0498 0.1542
Echinococcus multilocularis ferritin 0.0008 0.0027 0.0011
Leishmania major hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative 0.0016 0.0087 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0039 0.0022
Trichomonas vaginalis beta lactamase domain, putative 0.0016 0.0087 0.1731
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0007 0.0017 0.0053
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0009 0.0031 0.0014
Brugia malayi hypothetical protein 0.0009 0.0031 0.005
Mycobacterium tuberculosis Conserved protein 0.0016 0.0087 0.006
Onchocerca volvulus 0.0049 0.0355 1
Entamoeba histolytica type A flavoprotein, putative 0.0016 0.0087 0.3295
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0007 0.0017 0.0053
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0016 0.0087 1
Schistosoma mansoni neuropeptide receptor 0.0007 0.0017 0.0053
Toxoplasma gondii hydroxyacylglutathione hydrolase 0.0016 0.0087 0.2216
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0009 0.0031 0.005
Onchocerca volvulus 0.0009 0.0031 0.0404
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0009 0.0031 0.0014
Entamoeba histolytica hypothetical protein, conserved 0.0016 0.0087 0.3295
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0009 0.0031 0.005
Brugia malayi hypothetical protein 0.0009 0.0031 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0087 0.1731
Mycobacterium tuberculosis Conserved protein 0.0016 0.0087 0.006
Schistosoma mansoni alpha-1 adrenergic receptor 0.0007 0.0017 0.0053
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0009 0.0031 0.005
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0009 0.0031 0.0014
Mycobacterium tuberculosis Conserved hypothetical protein 0.0016 0.0087 0.006
Echinococcus granulosus hydroxyacylglutathione hydrolase 0.0016 0.0087 0.0071
Trichomonas vaginalis beta lactamase domain, putative 0.0016 0.0087 0.1731
Schistosoma mansoni hypothetical protein 0.0034 0.0232 0.0719
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0031 0.0014
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0009 0.0031 0.005
Echinococcus multilocularis cpg binding protein 0.003 0.0202 0.0186
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0009 0.0031 0.0014
Schistosoma mansoni biogenic amine receptor 0.0007 0.0017 0.0053
Schistosoma mansoni apoferritin-2 0.0008 0.0027 0.0085
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0009 0.0031 0.005
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0089 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0009 0.0031 0.005
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0498 0.1752
Trichomonas vaginalis pten, drome, putative 0.0009 0.0031 0.0434
Echinococcus granulosus tar DNA binding protein 0.0067 0.0498 0.0482
Trichomonas vaginalis A-type flavoprotein 0.0016 0.0087 0.1731
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0189 0.0628
Loa Loa (eye worm) hypothetical protein 0.0016 0.0087 0.0257
Trypanosoma brucei cleavage and polyadenylation specificity factor subunit, putative 0.0016 0.0087 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0009 0.0031 0.0014
Schistosoma mansoni neuropeptide F-like receptor 0.0007 0.0017 0.0053
Schistosoma mansoni histamine h1 receptor 0.0007 0.0017 0.0053
Schistosoma mansoni hypothetical protein 0.0016 0.0086 0.0265
Loa Loa (eye worm) hydroxyacylglutathione hydrolase 0.0016 0.0087 0.0257
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0009 0.0031 0.0014
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0088 0.2226
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0355 0.1099
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0087 0.1731
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0009 0.0031 0.0014
Echinococcus granulosus expressed protein 0.0008 0.0027 0.0011
Loa Loa (eye worm) hypothetical protein 0.0009 0.0031 0.005
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0009 0.0031 0.0014
Schistosoma mansoni hypothetical protein 0.0007 0.0017 0.0053
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0039 0.0022
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0009 0.0031 0.0014
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0031 0.005
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0009 0.0031 0.005
Trichomonas vaginalis apoptosis inducing factor, putative 0.0016 0.0087 0.1731
Onchocerca volvulus 0.0009 0.0031 0.0404
Entamoeba histolytica hypothetical protein 0.0038 0.0265 1
Schistosoma mansoni ferritin 0.0008 0.0027 0.0085
Entamoeba histolytica hypothetical protein 0.0038 0.0265 1
Onchocerca volvulus 0.0009 0.0031 0.0404
Onchocerca volvulus 0.0009 0.0031 0.0404
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0017 0.0053
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0358 0.1243
Entamoeba histolytica metallo-beta-lactamase family protein 0.0016 0.0087 0.3295
Loa Loa (eye worm) hypothetical protein 0.0009 0.0031 0.005
Loa Loa (eye worm) hypothetical protein 0.0009 0.0031 0.005
Onchocerca volvulus 0.0009 0.0031 0.0404
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0009 0.0031 0.0014
Echinococcus multilocularis tumor protein p63 0.0334 0.266 0.2648
Brugia malayi Protein-tyrosine phosphatase 1 0.0009 0.0031 0.005
Loa Loa (eye worm) DnaJ domain-containing protein 0.0061 0.0449 0.1575
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0009 0.0031 0.005
Schistosoma mansoni protein tyrosine phosphatase 0.0009 0.0031 0.0095
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0086 0.0069
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0062 0.2343
Leishmania major metallo-beta-lactamase family-like protein 0.0016 0.0087 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0007 0.0017 0.0053
Echinococcus multilocularis hydroxyacylglutathione hydrolase 0.0016 0.0087 0.0071
Loa Loa (eye worm) hypothetical protein 0.0016 0.0087 0.0257
Trichomonas vaginalis beta lactamase domain, putative 0.0016 0.0087 0.1731
Schistosoma mansoni hypothetical protein 0.0016 0.0087 0.0271
Onchocerca volvulus 0.0016 0.0087 0.2084
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0007 0.0017 0.0053
Onchocerca volvulus 0.0009 0.0031 0.0404
Onchocerca volvulus Putative hydrolase PNKD 0.0016 0.0087 0.2084
Onchocerca volvulus 0.0009 0.0031 0.0404
Loa Loa (eye worm) hypothetical protein 0.0009 0.0031 0.005
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0009 0.0031 0.005
Mycobacterium ulcerans hypothetical protein 0.0016 0.0087 0.006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0017 0.0053
Entamoeba histolytica alkyl sulfatase, putative 0.0016 0.0087 0.3295
Treponema pallidum bacterioferrin (TpF1) 0.0008 0.0027 0.3134
Schistosoma mansoni growth hormone secretagogue receptor 0.0007 0.0017 0.0053
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0017 0.0053
Loa Loa (eye worm) hypothetical protein 0.0009 0.0031 0.005
Onchocerca volvulus 0.0009 0.0031 0.0404
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0009 0.0031 0.005
Brugia malayi hypothetical protein 0.0038 0.0265 0.0905
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0062 0.5548
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0007 0.0017 0.0053
Schistosoma mansoni zinc phosphodiesterase 0.0016 0.0087 0.0271
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0016 0.0087 0.3295
Mycobacterium tuberculosis Beta lactamase like protein 0.0016 0.0087 0.006
Loa Loa (eye worm) hydroxyacylglutathione hydrolase cytoplasmic 0.0016 0.0087 0.0257
Schistosoma mansoni amine GPCR 0.0007 0.0017 0.0053
Onchocerca volvulus 0.0009 0.0031 0.0404
Echinococcus granulosus zinc phosphodiesterase 0.0016 0.0087 0.0071
Trypanosoma brucei metallo-beta-lactamase-like protein, putative 0.0016 0.0087 1
Schistosoma mansoni hypothetical protein 0.0061 0.0449 0.1391
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0009 0.0031 0.0014
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0009 0.0031 0.0014
Schistosoma mansoni cpg binding protein 0.003 0.0202 0.0626
Trypanosoma brucei hydroxyacylglutathione hydrolase, putative 0.0016 0.0087 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0009 0.0031 0.0014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0017 0.0053
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0016 0.0087 0.0071
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0358 0.1243
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0009 0.0031 0.0014
Echinococcus granulosus dnaJ subfamily C 6 0.0061 0.0449 0.0433
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0031 0.005
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0031 0.005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0012 0.00000000074633
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0009 0.0031 0.0095
Brugia malayi hypothetical protein 0.0009 0.0031 0.005
Mycobacterium ulcerans hydrolase 0.0016 0.0087 0.006
Trypanosoma cruzi glyoxalase II 0.0016 0.0087 1
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0016 0.0087 1
Schistosoma mansoni DNA helicase recq5 0.001 0.0039 0.012
Schistosoma mansoni biogenic amine receptor 0.0007 0.0017 0.0053
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0062 0.5548
Brugia malayi Protein-tyrosine phosphatase 0.0009 0.0031 0.005
Schistosoma mansoni ferritin 0.0008 0.0027 0.0085
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0031 0.005
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0151 0.3196
Mycobacterium leprae conserved hypothetical protein 0.0016 0.0087 0.0217
Mycobacterium ulcerans hydrolase 0.0016 0.0087 0.006
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0007 0.0017 0.0053
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.1232
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0394 1
Schistosoma mansoni neuropeptide receptor 0.0007 0.0017 0.0053
Wolbachia endosymbiont of Brugia malayi metallo-beta-lactamase superfamily hydrolase 0.0016 0.0087 1
Schistosoma mansoni hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) 0.0016 0.0087 0.0271
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0009 0.0031 0.0095
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0016 0.0087 0.3295
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0016 0.0087 0.0071
Trypanosoma cruzi glyoxalase II 0.0016 0.0087 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0031 0.005
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0009 0.0031 0.0014
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0151 0.3196
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0016 0.0087 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0017 0.0053
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0012 0.00000000074633
Brugia malayi Protein-tyrosine phosphatase 0.0009 0.0031 0.005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0012 0.00000000074633
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0031 0.005
Echinococcus granulosus dnaJ subfamily B 0.0404 0.3228 0.3217
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0009 0.0031 0.0014
Echinococcus multilocularis hypothetical protein 0.0009 0.0031 0.0014
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0009 0.0031 0.0014
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0012 0.00000000074633
Loa Loa (eye worm) hypothetical protein 0.0009 0.0031 0.005
Entamoeba histolytica hypothetical protein 0.0038 0.0265 1
Schistosoma mansoni zinc phosphodiesterase 0.0016 0.0087 0.0271
Echinococcus multilocularis thymidine phosphorylase 0.1241 1 1
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0009 0.0031 0.0095
Mycobacterium leprae POSSIBLE HYDROLASE 0.0016 0.0087 0.0217
Mycobacterium ulcerans thymidine phosphorylase 0.1241 1 1
Schistosoma mansoni pcd6 interacting protein-related 0.0009 0.0031 0.0095
Echinococcus granulosus bloom syndrome protein 0.0024 0.0151 0.0135
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0012 0.00000000074633
Schistosoma mansoni hypothetical protein 0.0007 0.0017 0.0053
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0031 0.005
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0086 0.0069
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0017 0.0053
Brugia malayi hypothetical protein 0.0016 0.0087 0.0257
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0031 0.005
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0007 0.0017 0.0053
Schistosoma mansoni opsin-like receptor 0.0007 0.0017 0.0053
Loa Loa (eye worm) hypothetical protein 0.0009 0.0031 0.005
Echinococcus multilocularis dnaJ subfamily C 6 0.0061 0.0449 0.0433
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0265 0.0249
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0039 0.0022
Loa Loa (eye worm) hypothetical protein 0.0009 0.0031 0.005
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0007 0.0017 0.0053
Mycobacterium tuberculosis Conserved hypothetical protein 0.0016 0.0087 0.006
Trypanosoma brucei glyoxalase II 0.0016 0.0087 1
Onchocerca volvulus 0.0009 0.0031 0.0404
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0031 0.005
Treponema pallidum ribonuclease Z 0.0016 0.0087 1
Schistosoma mansoni amine GPCR 0.0007 0.0017 0.0053
Schistosoma mansoni amine GPCR 0.0007 0.0017 0.0053
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0007 0.0017 0.0053
Echinococcus multilocularis 0.0009 0.0031 0.0014
Onchocerca volvulus 0.0009 0.0031 0.0404
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0031 0.005
Schistosoma mansoni myosin xvIII 0.0007 0.0017 0.0053
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0031 0.005
Brugia malayi Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. 0.0016 0.0087 0.0257
Mycobacterium ulcerans hypothetical protein 0.0016 0.0087 0.006
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0346 0.276 0.2748
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0009 0.0031 0.005
Loa Loa (eye worm) hypothetical protein 0.0009 0.0031 0.005
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0086 0.025
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0009 0.0031 0.1155
Chlamydia trachomatis ribonuclease Z 0.0016 0.0087 0.5
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0009 0.0031 0.0014
Entamoeba histolytica metallo-beta-lactamase family protein 0.0016 0.0087 0.3295
Loa Loa (eye worm) hypothetical protein 0.0016 0.0087 0.0257
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0086 0.025
Toxoplasma gondii metallo-beta-lactamase domain-containing protein 0.0016 0.0087 0.2216
Loa Loa (eye worm) hypothetical protein 0.0009 0.0031 0.005
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0031 0.005
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0031 0.005
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0009 0.0031 0.005
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0009 0.0031 0.0014
Schistosoma mansoni biogenic amine (5HT) receptor 0.0007 0.0017 0.0053
Schistosoma mansoni ferritin light chain 0.0008 0.0027 0.0085

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 1.94 Antifungal activity against Magnaporthe grisea infected rice plant assessed as logarithm of fungal control value at 100 ppm after 5 days ChEMBL. 18299194

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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