TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 540.65 | Formula: C26H44N4O8
H donors: 5 H acceptors: 6 LogP: 1.44 Rotable bonds: 19
Rule of 5 violations (Lipinski): 2
SMILES: CCOC(=O)/C=C/[C@@H](NC(=O)[C@H]([C@H](O)C)NC(=O)[C@H]([C@H](CC)C)NC(=O)OC(C)(C)C)C[C@@H]1CCNC1=O
InChi: 1S/C26H44N4O8/c1-8-15(3)20(30-25(36)38-26(5,6)7)23(34)29-21(16(4)31)24(35)28-18(10-11-19(32)37-9-2)14-17-12-13-27-22(17)33/h10-11,15-18,20-21,31H,8-9,12-14H2,1-7H3,(H,27,33)(H,28,35)(H,29,34)(H,30,36)/b11-10+/t15-,16+,17-,18+,20-,21-/m0/s1
InChiKey: FYCIRPXZZGAMBP-TZSXNGMNSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	dna polymerase kappa	0.0041	0.0529	0.0774
Echinococcus multilocularis	geminin	0.0181	0.3472	0.5074
Trypanosoma cruzi	cytochrome P450, putative	0.0041	0.0532	1
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0033	0.0346	0.2867
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0058	0.088	0.1286
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0027	0.0233	0.0233
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0033	0.0346	0.2867
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0529	0.9945
Schistosoma mansoni	hypothetical protein	0.0127	0.2333	0.656
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0058	0.088	0.1286
Loa Loa (eye worm)	hypothetical protein	0.0058	0.088	0.088
Entamoeba histolytica	hypothetical protein	0.0036	0.0421	0.5
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0529	0.9945
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0233	0.0233
Brugia malayi	Nuclear hormone receptor-like 1	0.0031	0.0303	0.0303
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0041	0.0532	0.3098
Echinococcus granulosus	geminin	0.0181	0.3472	0.5074
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0058	0.088	0.1286
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0058	0.088	0.088
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0529	0.9945
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0033	0.0346	0.2867
Brugia malayi	Protein kinase domain containing protein	0.0016	0.000000019944	0.000000019944
Schistosoma mansoni	RAR-like nuclear receptor	0.0058	0.088	0.2473
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0058	0.088	0.1286
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0529	0.9945
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0027	0.0233	0.0656
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0947	0.2663
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0058	0.088	0.1286
Loa Loa (eye worm)	cytochrome P450 family protein	0.0041	0.0532	0.0532
Entamoeba histolytica	hypothetical protein	0.0036	0.0421	0.5
Echinococcus granulosus	thyroid hormone receptor alpha	0.0027	0.0233	0.0341
Trypanosoma brucei	cytochrome P450, putative	0.0041	0.0532	1
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0027	0.0233	0.0341
Trypanosoma brucei	DNA polymerase IV, putative	0.0041	0.0529	0.9945
Schistosoma mansoni	thyroid hormone receptor	0.0185	0.3557	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0104	0.1825
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0041	0.0529	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0058	0.088	0.088
Brugia malayi	Nuclear hormone receptor-like 1	0.0031	0.0303	0.0303
Brugia malayi	Uncoordinated protein 44	0.0016	0.000000019944	0.000000019944
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0233	0.0233
Mycobacterium leprae	Conserved hypothetical protein	0.0033	0.0346	0.5
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0058	0.088	0.2473
Brugia malayi	nuclear receptor NHR-67	0.0027	0.0233	0.0233
Loa Loa (eye worm)	hypothetical protein	0.0058	0.088	0.088
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0033	0.0346	0.2867
Brugia malayi	MH2 domain containing protein	0.012	0.2195	0.2195
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0061	0.0947	1
Toxoplasma gondii	aldehyde dehydrogenase	0.0061	0.0947	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0041	0.0529	0.9847
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0058	0.088	0.2473
Loa Loa (eye worm)	nuclear hormone receptor	0.0027	0.0233	0.0233
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0058	0.088	0.088
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0061	0.0947	0.1385
Echinococcus granulosus	nuclear receptor nhr 48	0.0027	0.0233	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0233	0.0233
Mycobacterium ulcerans	DNA polymerase IV	0.0041	0.0529	0.305
Schistosoma mansoni	nuclear hormone receptor	0.0027	0.0233	0.0656
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0033	0.0346	0.2867
Onchocerca volvulus		0.005	0.0708	0.8045
Brugia malayi	nuclear receptor NHR-88	0.0027	0.0233	0.0233
Brugia malayi	Nuclear hormone receptor E75	0.0027	0.0233	0.0233
Trypanosoma brucei	DNA polymerase IV, putative	0.0035	0.0389	0.7266
Brugia malayi	ecdysteroid receptor	0.0058	0.088	0.088
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0058	0.088	0.2473
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0947	0.2663
Echinococcus multilocularis	ecdysone induced protein 78C	0.0058	0.088	0.1286
Schistosoma mansoni	nuclear receptor	0.0027	0.0233	0.0656
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0233	0.0233
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0027	0.0233	0.0341
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0058	0.088	0.088
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0033	0.0346	0.2867
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0041	0.0529	0.9847
Brugia malayi	polk-prov protein	0.0031	0.0317	0.0317
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0041	0.0529	0.9847
Leishmania major	cytochrome p450-like protein	0.0033	0.0346	0.2867
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0083	0.1418	0.2072
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0027	0.0233	0.0341
Loa Loa (eye worm)	cytochrome P450 family protein	0.0033	0.0346	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0303	0.0303
Onchocerca volvulus		0.0027	0.0233	0.2652
Brugia malayi	hypothetical protein	0.0031	0.0303	0.0303
Brugia malayi	hypothetical protein	0.0036	0.0421	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0058	0.088	0.088
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0303	0.0303
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0058	0.088	0.1286
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0031	0.0303	0.0303
Brugia malayi	ecdysone receptor	0.0027	0.0233	0.0233
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0058	0.088	0.1286
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0027	0.0233	0.0656
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0058	0.088	0.088
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0947	1
Schistosoma mansoni	hypothetical protein	0.0181	0.3472	0.976
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0033	0.0346	0.2867
Schistosoma mansoni	retinoic acid receptor RXR	0.0058	0.088	0.2473
Echinococcus multilocularis	dna polymerase kappa	0.0041	0.0529	0.0774
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0031	0.0303	0.0442
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0127	0.2333	0.341
Brugia malayi	Steroid receptor seven-up type 2	0.0058	0.088	0.088
Leishmania major	cytochrome p450-like protein	0.0041	0.0532	0.5077
Loa Loa (eye worm)	CYP4Cod1	0.0041	0.0532	0.0532
Brugia malayi	nuclear receptor NHR-88	0.0058	0.088	0.088
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0058	0.088	0.2473
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0058	0.088	0.1286
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0027	0.0233	0.0233
Echinococcus granulosus	FTZ F1 alpha	0.0058	0.088	0.1286
Brugia malayi	hypothetical protein	0.0031	0.0303	0.0303
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0058	0.088	0.088
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0016	0.000000019944	0.000000029149
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0027	0.0233	0.2652
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0127	0.2333	0.341
Schistosoma mansoni	zinc finger protein	0.0027	0.0233	0.0656
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0058	0.088	0.088
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0947	1
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0016	0.0003	0.0008
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0027	0.0233	0.2652
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0303	0.0303
Brugia malayi	nuclear receptor RXR	0.0031	0.0303	0.0303
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0033	0.0346	0.2867
Brugia malayi	Nuclear hormone receptor-like 1	0.0058	0.088	0.088
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0033	0.0346	0.2867
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0027	0.0233	0.0341
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0016	0.000000019944	0.000000029149
Giardia lamblia	DINP protein human, muc B family	0.0021	0.0104	0.5
Loa Loa (eye worm)	cytochrome P450 family protein	0.0041	0.0532	0.0532
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0041	0.0529	0.9847
Brugia malayi	photoreceptor-specific nuclear receptor	0.0058	0.088	0.088
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0033	0.0346	0.2867
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0421	0.0616
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0033	0.0346	0.6441
Schistosoma mansoni	cytochrome P450	0.0033	0.0346	0.0972
Brugia malayi	hypothetical protein	0.0027	0.0233	0.0233
Brugia malayi	hypothetical protein	0.0027	0.0233	0.0233
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0083	0.1418	0.2072
Echinococcus multilocularis	nuclear receptor nhr 48	0.0027	0.0233	0.0341
Trypanosoma brucei	DNA polymerase IV, putative	0.0041	0.0529	0.9945
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0421	0.0616
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0033	0.0346	0.2867
Schistosoma mansoni	hypothetical protein	0.0036	0.0421	0.1184
Brugia malayi	Death domain containing protein	0.0016	0.000000019944	0.000000019944
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0058	0.088	0.1286
Brugia malayi	Cytochrome P450 family protein	0.0033	0.0346	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0233	0.0233
Trypanosoma cruzi	cytochrome P450, putative	0.0041	0.0532	1
Brugia malayi	steroid hormone receptor	0.0058	0.088	0.088
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0027	0.0233	0.0341
Schistosoma mansoni	thyroid hormone receptor	0.0185	0.3557	1
Schistosoma mansoni	cellular tumor antigen P53	0.005	0.0708	0.199
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0058	0.088	0.088
Trypanosoma brucei	DNA polymerase kappa, putative	0.0031	0.0317	0.5891
Trypanosoma brucei	unspecified product	0.0035	0.0389	0.7266
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0489	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0058	0.088	0.088
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0061	0.0947	1
Brugia malayi	nuclear hormone receptor	0.0058	0.088	0.088
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0033	0.0346	0.2867
Schistosoma mansoni	nuclear receptor nhr-48	0.0027	0.0233	0.0656
Schistosoma mansoni	ankyrin 23/unc44	0.0016	0.000000019944	0.000000056067
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0058	0.088	0.088
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0233	0.0233
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0529	0.9945
Loa Loa (eye worm)	hypothetical protein	0.0058	0.088	0.088
Loa Loa (eye worm)	DR-78	0.0027	0.0233	0.0233
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0058	0.088	0.088
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0317	0.0317
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0058	0.088	0.088
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0027	0.0233	0.0233
Brugia malayi	Nuclear hormone receptor E75	0.0027	0.0233	0.0233
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0233	0.0233
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0529	0.9945
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0058	0.088	0.088
Entamoeba histolytica	hypothetical protein	0.0036	0.0421	0.5
Brugia malayi	Cytochrome P450 family protein	0.0041	0.0532	0.0532
Echinococcus multilocularis	Ankyrin	0.0016	0.0003	0.0004
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0031	0.0303	0.0851
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0058	0.088	0.088
Schistosoma mansoni	nuclear hormone receptor	0.0027	0.0233	0.0656
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0058	0.088	0.088
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0027	0.0233	0.0341
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0033	0.0346	0.2867
Schistosoma mansoni	nuclear receptor	0.0027	0.0233	0.0656
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0421	0.1184
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0058	0.088	0.2473
Echinococcus multilocularis	tumor protein p63	0.034	0.6842	1
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0031	0.0303	0.0442
Echinococcus multilocularis		0.0033	0.0346	0.0506
Brugia malayi	Cytochrome P450 family protein	0.0033	0.0346	0.0346
Loa Loa (eye worm)	steroid hormone receptor	0.0058	0.088	0.088
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0233	0.0233
Loa Loa (eye worm)	hypothetical protein	0.0058	0.088	0.088
Schistosoma mansoni	hypothetical protein	0.0181	0.3472	0.976
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0033	0.0346	0.2867
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0058	0.088	0.2473
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0033	0.0346	0.2867
Echinococcus granulosus	tumor protein p63	0.034	0.6842	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0031	0.0317	0.5891
Brugia malayi	cytochrome P450	0.0033	0.0346	0.0346
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0058	0.088	0.088
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0027	0.0233	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0233	0.0233
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0058	0.088	0.088
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0058	0.088	0.1286
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0058	0.088	0.088
Schistosoma mansoni	coup transcription factor	0.0058	0.088	0.2473
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0031	0.0303	0.0851
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0061	0.0947	0.1385
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0947	1
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0033	0.0346	0.2867
Loa Loa (eye worm)	hypothetical protein	0.0058	0.088	0.088
Mycobacterium ulcerans	DNA polymerase IV	0.0041	0.0529	0.305
Brugia malayi	nuclear hormone receptor family member odr-7	0.0027	0.0233	0.0233
Brugia malayi	conserved hypotetical protein	0.0027	0.0233	0.0233
Loa Loa (eye worm)	transcription factor SMAD2	0.012	0.2195	0.2195
Loa Loa (eye worm)	hypothetical protein	0.0058	0.088	0.088
Brugia malayi	Cytochrome P450 family protein	0.0041	0.0532	0.0532
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0027	0.0233	0.0233
Brugia malayi	tailless protein	0.0027	0.0233	0.0233
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0058	0.088	0.1286
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0233	0.0233
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0233	0.0233
Mycobacterium leprae	putative cytochrome p450	0.0033	0.0346	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0033	0.0346	0.2867
Trichomonas vaginalis	DNA polymerase eta, putative	0.0041	0.0529	0.5
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0058	0.088	0.1286
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0033	0.0346	0.2867
Entamoeba histolytica	hypothetical protein	0.0036	0.0421	0.5
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0529	0.9945
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0233	0.0233
Leishmania major	cytochrome p450-like protein	0.0033	0.0346	0.2867
Loa Loa (eye worm)	hypothetical protein	0.0058	0.088	0.088
Schistosoma mansoni	nuclear hormone receptor	0.0058	0.088	0.2473
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0033	0.0346	0.2867
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0058	0.088	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0529	0.9945
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0033	0.0346	0.2867
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0027	0.0233	0.0341
Loa Loa (eye worm)	cytochrome P450	0.0033	0.0346	0.0346
Echinococcus multilocularis	FTZ F1 alpha	0.0058	0.088	0.1286
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0185	0.3557	0.5199
Echinococcus granulosus	ecdysone induced protein 78C	0.0058	0.088	0.1286
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0027	0.0233	0.0341
Brugia malayi	nuclear hormone receptor	0.0027	0.0233	0.0233
Schistosoma mansoni	hypothetical protein	0.0033	0.0346	0.0972
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0303	0.0303
Brugia malayi	nuclear receptor RXR	0.0027	0.0233	0.0233
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0058	0.088	0.2473
Echinococcus granulosus	cytochrome P450 2K1	0.0033	0.0346	0.0506
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0033	0.0346	0.2867
Echinococcus granulosus	Ankyrin	0.0016	0.0003	0.0004
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0529	0.9945
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0003	0.0003
Onchocerca volvulus	Protein ultraspiracle homolog	0.0058	0.088	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0058	0.088	0.088
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0058	0.088	0.088
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0058	0.088	0.1286
Onchocerca volvulus	Bile acid receptor homolog	0.0058	0.088	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0303	0.0303
Loa Loa (eye worm)	MH2 domain-containing protein	0.012	0.2195	0.2195
Onchocerca volvulus		0.0058	0.088	1
Brugia malayi	orphan nuclear receptor NR2E1	0.0027	0.0233	0.0233
Loa Loa (eye worm)	hypothetical protein	0.005	0.0708	0.0708
Onchocerca volvulus		0.0027	0.0233	0.2652
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0233	0.0233

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= -16.67 %	Antifroliferative activity against human Bel7402 cells at 10 umole	ChEMBL.	18280155
Activity (functional)	= -16.67 %	Antifroliferative activity against human Bel7402 cells at 10 umole	ChEMBL.	18280155
Activity (functional)	= -10.29 %	Antifroliferative activity against human KB cells at 10 umole	ChEMBL.	18280155
Activity (functional)	= -10.29 %	Antifroliferative activity against human KB cells at 10 umole	ChEMBL.	18280155
Activity (functional)	= 0.69 %	Antifroliferative activity against human BGC823 cells at 10 umole	ChEMBL.	18280155
Activity (functional)	= 0.69 %	Antifroliferative activity against human BGC823 cells at 10 umole	ChEMBL.	18280155
Activity (functional)	= 0.71 %	Antifroliferative activity against human HL60 cells at 10 umole	ChEMBL.	18280155
Activity (functional)	= 0.71 %	Antifroliferative activity against human HL60 cells at 10 umole	ChEMBL.	18280155
IC50 (binding)	> 100 umol	Inhibition of chymotrypsin-like activity of 20S proteasome (unknown origin)	ChEMBL.	18280155
IC50 (binding)	> 100 umol	Inhibition of post acidic-like activity of 20S proteasome (unknown origin)	ChEMBL.	18280155
IC50 (binding)	> 100 umol	Inhibition of trypsin-like activity of 20S proteasome (unknown origin)	ChEMBL.	18280155

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 517673