Detailed information for compound 518182

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 491.945 | Formula: C26H23ClFN5O2
  • H donors: 0 H acceptors: 5 LogP: 4.74 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=Cc1ccc(c(c1)Cl)c1nnc(n1C)C12CCC(CC1)(CC2)c1onc(n1)c1ccc(cc1)F
  • InChi: 1S/C26H23ClFN5O2/c1-33-22(19-7-2-16(15-34)14-20(19)27)30-31-23(33)25-8-11-26(12-9-25,13-10-25)24-29-21(32-35-24)17-3-5-18(28)6-4-17/h2-7,14-15H,8-13H2,1H3
  • InChiKey: BWRXEWQJJDSTJX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens hydroxysteroid (11-beta) dehydrogenase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans short chain dehydrogenase Get druggable targets OG5_132866 All targets in OG5_132866
Mycobacterium tuberculosis Probable oxidoreductase Get druggable targets OG5_132866 All targets in OG5_132866
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum steroid dehydrogenase, putative hydroxysteroid (11-beta) dehydrogenase 1 292 aa 250 aa 24.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0188 0.1485 0.3402
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0019 0.0049 0.013
Loa Loa (eye worm) phosphofructokinase 0.0111 0.0833 0.191
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.0833 0.3348
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0071 0.049 0.0487
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0146 0.0224
Schistosoma mansoni tyrosine kinase 0.0024 0.0097 0.0102
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.0253 0.0935
Loa Loa (eye worm) hypothetical protein 0.017 0.1326 0.3039
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0295 0.2392 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0464 0.1029
Echinococcus granulosus dihydrofolate reductase 0.0071 0.049 0.0488
Echinococcus multilocularis glutamate receptor 2 0.0528 0.4364 0.4362
Echinococcus multilocularis metabotropic glutamate receptor 5 0.029 0.2349 0.2347
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0253 0.2031 0.2029
Loa Loa (eye worm) doublecortin family protein 0.0018 0.0042 0.0097
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.0833 0.191
Brugia malayi SRC-1 0.0024 0.0097 0.0186
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0212 0.1685 0.1683
Echinococcus granulosus death domain containing protein 0.0015 0.0016 0.0014
Wolbachia endosymbiont of Brugia malayi 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0698 0.5801 1
Echinococcus multilocularis glutamate receptor 2 0.07 0.5813 0.5812
Loa Loa (eye worm) phosphatidylinositol 3 0.0225 0.1795 0.4114
Brugia malayi Protein kinase domain containing protein 0.0198 0.1568 0.357
Schistosoma mansoni glutamate receptor kainate 0.0528 0.4364 0.5489
Brugia malayi Guanylyl cyclase protein 23 0.0175 0.1374 0.3124
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0029 0.0136 0.0655
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0042 0.0249 0.0247
Schistosoma mansoni tyrosine kinase 0.0175 0.1374 0.1715
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0019 0.0049 0.0076
Loa Loa (eye worm) dihydrofolate reductase 0.0071 0.049 0.1123
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.005 0.0314 0.0311
Loa Loa (eye worm) glutamate receptor 1 0.0528 0.4364 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0071 0.049 0.0488
Leishmania major ATP-dependent phosphofructokinase 0.0111 0.0833 0.4862
Mycobacterium ulcerans aldehyde dehydrogenase 0.0055 0.0356 0.0525
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.002 0.006 0.0137
Schistosoma mansoni hypothetical protein 0.0363 0.296 0.3717
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0146 0.0224
Leishmania major protein kinase A catalytic subunit isoform 1 0.0019 0.0049 0.013
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0027 0.0025
Echinococcus multilocularis lamin 0.0028 0.0125 0.0122
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0019 0.0049 0.0056
Echinococcus multilocularis nmda type glutamate receptor 0.1194 1 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0253 0.2031 0.2544
Schistosoma mansoni kinase 0.0022 0.0078 0.0078
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0107 0.0797 0.3194
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0027 0.012 0.0561
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0004 0.0002
Leishmania major phosphatidylinositol 3-kinase, putative 0.0029 0.0136 0.0655
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0171 0.1341 0.1338
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0029 0.0136 0.0134
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0071 0.049 0.279
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0043 0.0253 0.058
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0057 0.0372 0.1378
Loa Loa (eye worm) hypothetical protein 0.0188 0.1485 0.3402
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0464 0.2631
Brugia malayi Doublecortin family protein 0.0018 0.0042 0.0061
Trypanosoma cruzi cdc2-related kinase 1 0.002 0.006 0.0194
Chlamydia trachomatis 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0698 0.5801 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0057 0.0372 0.1439
Trypanosoma cruzi Aminopeptidase M1, putative 0.0071 0.049 0.279
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.002 0.006 0.0194
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0101 0.075 0.0748
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0024 0.0097 0.0094
Loa Loa (eye worm) RGC/RGC protein kinase 0.0175 0.1374 0.3149
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0019 0.0049 0.013
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0071 0.049 0.1882
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0027 0.0025
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.068 0.5644 0.9727
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0027 0.0026
Trichomonas vaginalis CMGC family protein kinase 0.0043 0.0253 0.0871
Trichomonas vaginalis CMGC family protein kinase 0.002 0.006 0.0045
Echinococcus granulosus glutamate receptor 2 0.07 0.5813 0.5812
Chlamydia trachomatis dihydrofolate reductase 0.0071 0.049 0.0609
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.0401 0.0398
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0054 0.0047
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0019 0.0049 0.0046
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0054 0.0052
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0071 0.049 0.0487
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0055 0.0356 0.0354
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0076 0.0536 0.1229
Echinococcus granulosus RUN 0.0018 0.0042 0.004
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0054 0.0023
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0054 0.0023
Entamoeba histolytica PH domain containing protein kinase, putative 0.0019 0.0049 0.007
Schistosoma mansoni serine/threonine protein kinase 0.002 0.006 0.0055
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0054 0.0052
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0057 0.0372 0.0449
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0057 0.0372 0.1439
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0029 0.0136 0.0655
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0146 0.0205
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0007
Entamoeba histolytica serine/threonine protein kinase, putative 0.0042 0.0249 0.0919
Schistosoma mansoni hypothetical protein 0.0018 0.0042 0.0033
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0029 0.0136 0.0207
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0029 0.0136 0.0276
Schistosoma mansoni glutamate receptor AMPA 0.0528 0.4364 0.5489
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0025 0.0102 0.0108
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0042 0.0249 0.0571
Toxoplasma gondii AGC kinase 0.0019 0.0049 0.0059
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0363 0.296 0.2958
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0027 0.0014
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0071 0.049 0.0598
Plasmodium falciparum protein kinase 5 0.002 0.006 0.0056
Echinococcus multilocularis cyclin dependent kinase 5 0.002 0.006 0.0057
Schistosoma mansoni protein kinase 0.0175 0.1374 0.1715
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0212 0.1685 0.3862
Brugia malayi Receptor family ligand binding region containing protein 0.0188 0.1485 0.3378
Brugia malayi metabotropic glutamate receptor type 2 0.0212 0.169 0.3849
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0295 0.2392 0.4068
Echinococcus multilocularis lamin dm0 0.0028 0.0125 0.0122
Onchocerca volvulus 0.0018 0.0042 0.0074
Echinococcus multilocularis tyrosine protein kinase HCK 0.0017 0.0032 0.003
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0019 0.005 0.0047
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0029 0.0136 0.0371
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0029 0.0136 0.0209
Plasmodium vivax JmjC domain containing protein 0.0016 0.0027 0.0019
Echinococcus granulosus Ankyrin 0.0015 0.0017 0.0015
Echinococcus granulosus glutamate receptor subunit protein glur 0.0363 0.296 0.2959
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0029 0.0136 0.0371
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.1042 0.8713 0.8712
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0027 0.0021
Loa Loa (eye worm) hypothetical protein 0.029 0.2349 0.5382
Trichomonas vaginalis CAMK family protein kinase 0.0022 0.0073 0.0104
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0025 0.0102 0.0234
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0057 0.0372 0.1378
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0464 0.0461
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0146 0.0481
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0111 0.0833 0.1394
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0071 0.049 0.0758
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.07 0.5813 0.5812
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0071 0.049 0.0487
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0025 0.0102 0.0226
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0019 0.0049 0.013
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.005 0.0316 0.1743
Loa Loa (eye worm) hypothetical protein 0.0025 0.0102 0.0234
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0016 0.0000000091209
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0007
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0363 0.296 0.2959
Onchocerca volvulus 0.0065 0.0438 0.1744
Echinococcus granulosus cyclin dependent kinase 1 0.002 0.006 0.0057
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.07 0.5813 0.5812
Echinococcus granulosus tyrosine protein kinase Fyn 0.0024 0.0097 0.0094
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.0401 0.0398
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0076 0.0074
Loa Loa (eye worm) peptidase family M1 containing protein 0.0194 0.1537 0.3521
Plasmodium vivax 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.0698 0.5801 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0042 0.0249 0.1339
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0146 0.0414
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0043 0.0253 0.1361
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0017 0.0038 0.0036
Schistosoma mansoni aldehyde dehydrogenase 0.0055 0.0356 0.043
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0054 0.0046
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0212 0.1685 0.7005
Loa Loa (eye worm) hypothetical protein 0.0175 0.1374 0.3149
Brugia malayi Cytochrome P450 family protein 0.002 0.0065 0.0112
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0071 0.049 0.0488
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.002 0.006 0.0137
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0019 0.0049 0.013
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.07 0.5813 0.5812
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0017 0.0001
Entamoeba histolytica hypothetical protein 0.0171 0.1341 0.5545
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0027 0.0025
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0027 0.0025
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0019 0.0049 0.0046
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.002 0.006 0.0057
Onchocerca volvulus 0.0028 0.0125 0.0424
Echinococcus granulosus metabotropic glutamate receptor 5 0.029 0.2349 0.2347
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.068 0.5644 0.9727
Brugia malayi Protein kinase domain containing protein 0.0016 0.0027 0.0025
Mycobacterium ulcerans aldehyde dehydrogenase 0.0055 0.0356 0.0525
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0055 0.0356 0.0354
Schistosoma mansoni netrin receptor unc5 0.0016 0.0027 0.0014
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0023 0.0083 0.008
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0019 0.0049 0.0059
Trypanosoma cruzi aminopeptidase, putative 0.0025 0.0102 0.0449
Echinococcus multilocularis rho associated protein kinase 0.0065 0.0438 0.0435
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.068 0.5644 0.9722
Loa Loa (eye worm) AGC/PKA protein kinase 0.0019 0.0049 0.0112
Mycobacterium tuberculosis Probable oxidoreductase 0.0338 0.2752 0.4827
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0029 0.0136 0.0151
Loa Loa (eye worm) hypothetical protein 0.0025 0.0102 0.0234
Echinococcus granulosus tyrosine protein kinase Fyn 0.0024 0.0097 0.0094
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0212 0.1685 0.3839
Entamoeba histolytica aminopeptidase, putative 0.0071 0.049 0.1939
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0029 0.0136 0.0151
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0119 0.0899 0.1115
Trypanosoma cruzi cdc2-related kinase 3 0.002 0.006 0.0194
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.01 0.0734 0.0732
Brugia malayi serine/threonine-protein kinase plk-2 0.0042 0.0249 0.0536
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0017 0.0035 0.0044
Brugia malayi Peptidase family M1 containing protein 0.0071 0.049 0.109
Trypanosoma cruzi extracellular receptor, putative 0.0171 0.1341 0.7922
Schistosoma mansoni glutamate receptor NMDA 0.0852 0.7101 0.8945
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0054 0.0066
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0951 0.7936 0.7936
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0071 0.049 0.0487
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0024 0.0097 0.0094
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0076 0.0117
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0175 0.1374 0.5701
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0295 0.2392 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0042 0.0249 0.0247
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0178 0.1395 0.3172
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0146 0.0226
Loa Loa (eye worm) TATA binding protein associated factor 0.0025 0.0102 0.0234
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0017 0.0035 0.0044
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0027 0.0014
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.001
Schistosoma mansoni glutamate receptor AMPA 0.0528 0.4364 0.5489
Onchocerca volvulus 0.0025 0.0102 0.0326
Echinococcus multilocularis cyclin dependent kinase 1 0.002 0.006 0.0057
Schistosoma mansoni aminopeptidase A (M01 family) 0.0025 0.0102 0.0108
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0024 0.0097 0.0094
Onchocerca volvulus 0.0295 0.2392 1
Toxoplasma gondii 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.0698 0.5801 1
Toxoplasma gondii aldehyde dehydrogenase 0.0055 0.0356 0.059
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0188 0.1485 0.3402
Echinococcus multilocularis lipoxygenase domain containing protein 0.0018 0.0042 0.004
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.0833 0.3394
Chlamydia trachomatis glutamine binding protein 0.068 0.5644 0.9722
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0029 0.0136 0.0134
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0295 0.2392 1
Echinococcus multilocularis cyclin dependent kinase 0.002 0.006 0.0057
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0146 0.0414
Schistosoma mansoni lipoxygenase 0.005 0.0314 0.0376
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0212 0.1685 0.3862
Schistosoma mansoni ap endonuclease 0.0019 0.0054 0.0048
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0025 0.0102 0.0449
Onchocerca volvulus 0.0043 0.0253 0.0964
Echinococcus granulosus Polycystic kidney disease protein 0.0018 0.0042 0.004
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0089
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0146 0.0226
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0249 0.0855
Echinococcus granulosus tyrosine kinase 0.0023 0.0083 0.0081
Entamoeba histolytica cell division protein kinase 2, putative 0.002 0.006 0.0115
Schistosoma mansoni metabotropic glutamate receptor 0.0249 0.2 0.2505
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0102 0.0099
Echinococcus granulosus glutamate NMDA receptor subunit 0.0951 0.7936 0.7936
Echinococcus granulosus rho-associated protein kinase 1 0.0065 0.0438 0.0435
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0029 0.0136 0.0655
Loa Loa (eye worm) hypothetical protein 0.0018 0.0042 0.0097
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0025 0.0102 0.0129
Trypanosoma cruzi aminopeptidase, putative 0.0071 0.049 0.279
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0017 0.0038
Brugia malayi intermediate filament protein 0.0028 0.0125 0.0251
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0171 0.1341 0.3073
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0017 0.0001
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.07 0.5813 0.5812
Plasmodium vivax protein kinase Crk2 0.002 0.006 0.0074
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0019 0.0049 0.0047
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0054 0.0163
Echinococcus granulosus nmda type glutamate receptor 0.0323 0.2628 0.2626
Loa Loa (eye worm) hypothetical protein 0.0171 0.1341 0.3073
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0295 0.2392 0.5482
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0024 0.0097 0.0094
Brugia malayi 6-phosphofructokinase 0.0111 0.0833 0.188
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0019 0.0049 0.013
Loa Loa (eye worm) hypothetical protein 0.0019 0.0049 0.0112
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0049 0.0042
Schistosoma mansoni serine/threonine protein kinase 0.002 0.006 0.0055
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0029 0.0136 0.0209
Brugia malayi phosphofructokinase 0.0111 0.0833 0.188
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0146 0.0159
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0027 0.012 0.0182
Giardia lamblia Kinase, CMGC GSK 0.0043 0.0253 0.0871
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0065 0.0148
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.015 0.1159 0.4775
Onchocerca volvulus 0.024 0.1925 0.8025
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0698 0.5801 1
Loa Loa (eye worm) glutamate receptor 0.0266 0.2144 0.4913
Echinococcus multilocularis protein kinase shaggy 0.0043 0.0253 0.025
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0146 0.0226
Brugia malayi Metabotropic glutamate receptor precursor. 0.0266 0.2144 0.4894
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0249 0.0855
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.07 0.5813 0.5812
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0401 0.0486
Brugia malayi Peptidase family M1 containing protein 0.024 0.1925 0.439
Loa Loa (eye worm) hypothetical protein 0.0171 0.1341 0.3073
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0111 0.0833 0.1356
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0102 0.0099
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0178 0.1395 0.5775
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0464 0.0565
Loa Loa (eye worm) hypothetical protein 0.0046 0.028 0.0641
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0178 0.1395 0.5745
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.01 0.0734 0.0731
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0146 0.0414
Brugia malayi intracellular kinase 0.0043 0.0253 0.0545
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0363 0.296 0.2958
Echinococcus multilocularis aminopeptidase N 0.024 0.1925 0.1922
Brugia malayi hypothetical protein 0.0071 0.049 0.109
Brugia malayi dihydrofolate reductase family protein 0.0071 0.049 0.1091
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0027 0.0063
Toxoplasma gondii exonuclease III APE 0.0019 0.0054 0.0068
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.0833 0.3394
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0135 0.1033 0.4201
Loa Loa (eye worm) hypothetical protein 0.0046 0.028 0.0641
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.0833 0.191
Schistosoma mansoni rab6-interacting 0.0018 0.0042 0.0033
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0212 0.1685 1
Echinococcus granulosus netrin receptor unc 5 0.0016 0.0027 0.0025
Onchocerca volvulus 0.006 0.04 0.1586
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.0833 0.4862
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0249 0.2 0.1998
Entamoeba histolytica protein kinase, putative 0.0043 0.0253 0.0935
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0178 0.1395 0.5745
Loa Loa (eye worm) RGC/RGC protein kinase 0.0175 0.1374 0.3149
Trypanosoma brucei protein kinase, putative 0.0043 0.0253 0.1361
Echinococcus multilocularis netrin receptor unc 5 0.0016 0.0027 0.0024
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0054 0.0023
Loa Loa (eye worm) hypothetical protein 0.0018 0.0042 0.0097
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0027 0.012 0.0561
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0071 0.049 0.279
Trypanosoma cruzi cdc2-related kinase 1 0.002 0.006 0.0194
Trichomonas vaginalis CAMK family protein kinase 0.0022 0.0073 0.0104
Loa Loa (eye worm) TK protein kinase 0.0023 0.0083 0.0191
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0054 0.0163
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0019 0.0049 0.0047
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.0833 0.3394
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0071 0.049 0.0488
Loa Loa (eye worm) TK protein kinase 0.0017 0.0032 0.0074
Onchocerca volvulus 0.0071 0.049 0.1965
Trypanosoma cruzi polo-like protein kinase, putative 0.0042 0.0249 0.1339
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0464 0.2631
Schistosoma mansoni metabotropic glutamate receptor 0.0212 0.169 0.2113
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0023 0.0083 0.0081
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.0833 0.3348
Treponema pallidum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0698 0.5801 1
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0146 0.0414
Schistosoma mansoni tyrosine kinase 0.0103 0.076 0.0939
Trypanosoma brucei aminopeptidase, putative 0.0025 0.0102 0.0449
Loa Loa (eye worm) hypothetical protein 0.0171 0.1341 0.3073
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0295 0.2392 0.5465
Echinococcus granulosus tyrosine protein kinase Blk 0.0023 0.0083 0.0081
Loa Loa (eye worm) aminopeptidase N 0.0071 0.049 0.1123
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0029 0.0136 0.0439
Echinococcus granulosus lamin dm0 0.0028 0.0125 0.0123
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0016 0.0013
Brugia malayi cell division control protein 2 homolog 0.002 0.006 0.01
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0095 0.0695 0.156
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0025 0.0102 0.0449
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0212 0.1685 0.1683
Mycobacterium ulcerans 6-phosphofructokinase 0.0111 0.0833 0.1356
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0054 0.0093
Loa Loa (eye worm) hypothetical protein 0.0015 0.0016 0.0037
Mycobacterium leprae PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS 0.0698 0.5801 1
Trichomonas vaginalis CMGC family protein kinase 0.002 0.006 0.0045
Loa Loa (eye worm) SRC-1 0.0024 0.0097 0.0222
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0029 0.0136 0.0655
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0029 0.0136 0.0371
Echinococcus granulosus tyrosine protein kinase Lyn 0.0026 0.0108 0.0105
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0111 0.0833 0.0646
Echinococcus multilocularis tyrosine protein kinase shark 0.0103 0.076 0.0757
Schistosoma mansoni rab6-interacting 0.0018 0.0042 0.0033
Echinococcus granulosus protein kinase shaggy 0.0043 0.0253 0.0251
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0027 0.0025
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0125 0.0251
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0071 0.049 0.1882
Loa Loa (eye worm) AGC/PKA protein kinase 0.0019 0.0049 0.0112
Schistosoma mansoni polycystin 1-related 0.0018 0.0042 0.0033
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0363 0.296 0.2959
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0135 0.1033 0.4201
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0071 0.049 0.0488
Echinococcus granulosus lipoxygenase domain containing protein 0.0018 0.0042 0.004
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0125 0.0287
Loa Loa (eye worm) RGC/RGC protein kinase 0.0175 0.1374 0.3149
Brugia malayi Stress-activated protein kinase jnk-1 0.0101 0.075 0.1689
Echinococcus granulosus tyrosine protein kinase Src42A 0.0019 0.005 0.0047
Brugia malayi Receptor family ligand binding region containing protein 0.0175 0.1374 0.3124
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0071 0.049 0.0487
Loa Loa (eye worm) hypothetical protein 0.0171 0.1341 0.3073
Echinococcus multilocularis Ankyrin 0.0015 0.0017 0.0014
Trypanosoma cruzi cdc2-related kinase 3 0.002 0.006 0.0194
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0464 0.1062
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0017 0.0038 0.0035
Brugia malayi Immunoglobulin I-set domain containing protein 0.0076 0.0536 0.1197
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0212 0.1685 1
Giardia lamblia Kinase, CMGC CDK 0.002 0.006 0.0045
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0438 0.0532
Onchocerca volvulus 0.0175 0.1374 0.5701
Brugia malayi jmjC domain containing protein 0.0016 0.0027 0.0026
Loa Loa (eye worm) hypothetical protein 0.01 0.0734 0.1682
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0027 0.0014
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0043 0.0253 0.0251
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0055 0.0356 0.1984
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0212 0.1685 1
Echinococcus granulosus tyrosine protein kinase HCK 0.0017 0.0032 0.003
Echinococcus granulosus cyclin dependent kinase 5 0.002 0.006 0.0057
Loa Loa (eye worm) RecQ helicase 0.0022 0.0076 0.0175
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0223 0.022
Leishmania major extracellular receptor, putative 0.0171 0.1341 0.7922
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0046 0.028 0.0277
Brugia malayi Protein kinase domain containing protein 0.002 0.006 0.01
Echinococcus multilocularis NMDA receptor 0.0363 0.296 0.2958
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0249 0.0855
Entamoeba histolytica PH domain containing protein kinase, putative 0.0019 0.0049 0.007
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0016 0.0037
Loa Loa (eye worm) hypothetical protein 0.0215 0.1714 0.3928
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0025 0.0102 0.0099
Brugia malayi jmjC domain containing protein 0.006 0.0401 0.0886
Loa Loa (eye worm) hypothetical protein 0.0027 0.0121 0.0277
Echinococcus multilocularis GPCR, family 3, C terminal 0.0017 0.0035 0.0032
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0212 0.1685 0.2887
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0146 0.0414
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0071 0.049 0.078
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0043 0.0253 0.1361
Leishmania major protein kinase A catalytic subunit isoform 2 0.0019 0.0049 0.013
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0024 0.0097 0.0094
Trypanosoma brucei cdc2-related kinase 3 0.002 0.006 0.0194
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0076 0.0139
Schistosoma mansoni ap endonuclease 0.0019 0.0054 0.0048
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0212 0.1685 0.2885
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0025 0.0102 0.0108
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0049 0.0042
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0295 0.2392 1
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0057 0.0372 0.2078
Loa Loa (eye worm) hypothetical protein 0.0016 0.0027 0.0063
Loa Loa (eye worm) glutamate receptor 2 0.0528 0.4364 1
Schistosoma mansoni glutamate receptor NMDA 0.0951 0.7936 1
Echinococcus granulosus nuclear factor of activated T cells 5 0.0075 0.053 0.0527
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0071 0.049 0.0487
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0043 0.0253 0.058
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.0401 0.0399
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0363 0.296 0.2958
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0057 0.0372 0.1378
Brugia malayi Glutamate receptor 2 precursor 0.0528 0.4364 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.07 0.5813 0.5812
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0025 0.0102 0.0148
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0249 0.0855
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0295 0.2392 1
Echinococcus granulosus GPCR family 3 C terminal 0.0017 0.0035 0.0033
Giardia lamblia Kinase, CMGC CDK 0.002 0.006 0.0045
Brugia malayi hypothetical protein 0.0171 0.1341 0.3047
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.002 0.006 0.0194
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0024 0.0097 0.0094
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0249 0.0295
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0027 0.012 0.018
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0024 0.0097 0.0094
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0024 0.0097 0.0094
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0075 0.0527 0.1176
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0212 0.1685 0.6983
Brugia malayi protein-tyrosine kinase 0.0023 0.0083 0.0155
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0029 0.0136 0.0439
Echinococcus granulosus phd:f box containing protein 0.0016 0.0027 0.0025
Loa Loa (eye worm) hypothetical protein 0.0078 0.0553 0.1267
Echinococcus granulosus c-Jun N-terminal kinases 0.0101 0.075 0.0748
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0295 0.2392 0.4182
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0055 0.0356 0.054
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.002 0.006 0.0077
Brugia malayi 6-phosphofructokinase 0.0111 0.0833 0.188
Schistosoma mansoni aldehyde dehydrogenase 0.0055 0.0356 0.043
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0016 0.0027 0.0025
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0027 0.0021
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0019 0.0049 0.0046
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0019 0.0049 0.0046
Brugia malayi Dihydrofolate reductase 0.0071 0.049 0.1091
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0019 0.0049 0.0047
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0212 0.1685 0.3839
Toxoplasma gondii aminopeptidase N, putative 0.0025 0.0102 0.015
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.07 0.5813 0.5812
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0034 0.0183 0.0572
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0019 0.0049 0.013
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.0253 0.0935
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0212 0.1685 0.2108
Echinococcus multilocularis cyclin dependent kinase 1 0.002 0.006 0.0057
Plasmodium falciparum glycogen synthase kinase 3 0.0043 0.0253 0.0391
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0171 0.1341 0.3047
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0027 0.0025
Echinococcus multilocularis Zinc finger, PHD finger 0.0029 0.0136 0.0133
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.075 0.0927
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0295 0.2392 1
Echinococcus multilocularis glutamate receptor 2 0.0337 0.2745 0.2742
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0178 0.1395 0.825
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0027 0.0063
Trypanosoma brucei cdc2-related kinase 1 0.002 0.006 0.0194
Brugia malayi hypothetical protein 0.0018 0.0042 0.0061
Echinococcus granulosus 6 phosphofructokinase 0.0111 0.0833 0.0831
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0295 0.2392 1
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0025 0.0102 0.0449
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0049 0.0042
Echinococcus granulosus receptor type guanylyl cyclase 0.0175 0.1374 0.1372
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0464 0.2631
Entamoeba histolytica hypothetical protein 0.015 0.1159 0.4775
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.002 0.006 0.0137
Loa Loa (eye worm) hypothetical protein 0.0016 0.0027 0.0063
Echinococcus granulosus metabotropic glutamate receptor 2 0.0249 0.2 0.1998
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0024 0.0097 0.0094
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0295 0.2392 1
Onchocerca volvulus 0.0171 0.1341 0.5559
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0025 0.0102 0.0449
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0054 0.0088
Trypanosoma brucei Aminopeptidase M1, putative 0.0071 0.049 0.279
Echinococcus granulosus lysine specific demethylase 5A 0.006 0.0401 0.0399
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.068 0.5644 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.0024 0.0097 0.0094
Loa Loa (eye worm) hypothetical protein 0.0015 0.0017 0.0039
Schistosoma mansoni intermediate filament proteins 0.0028 0.0125 0.0138
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0363 0.296 0.2959
Echinococcus granulosus tyrosine protein kinase Src42A 0.0024 0.0097 0.0094
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0043 0.0253 0.0412
Echinococcus granulosus atrial natriuretic peptide receptor 0.0171 0.1341 0.1339
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0054 0.0163
Brugia malayi jmjC domain containing protein 0.006 0.0401 0.0886
Loa Loa (eye worm) hypothetical protein 0.0171 0.1341 0.3073
Echinococcus multilocularis nmda type glutamate receptor 0.0323 0.2628 0.2626
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0171 0.134 0.5539
Schistosoma mansoni loxhd1 0.0018 0.0042 0.0033
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0025 0.0102 0.0129
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0071 0.049 0.0598
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0016 0.0014
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0295 0.2392 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0146 0.0205
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0027 0.0014
Schistosoma mansoni jumonji domain containing protein 0.006 0.0401 0.0486
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0401 0.0919
Plasmodium vivax multidomain scavenger receptor, putative 0.0018 0.0042 0.0045
Mycobacterium ulcerans aminopeptidase N PepN 0.0071 0.049 0.0758
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0146 0.0414
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0029 0.0136 0.0312
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0046 0.028 0.0333
Toxoplasma gondii aminopeptidase n, putative 0.0025 0.0102 0.015
Trichomonas vaginalis CMGC family protein kinase 0.002 0.006 0.0045
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0027 0.012 0.0161
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0054 0.0163
Echinococcus granulosus leukotriene A 4 hydrolase 0.0025 0.0102 0.0099
Loa Loa (eye worm) hypothetical protein 0.0017 0.0035 0.0081
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.07 0.5813 0.5812
Schistosoma mansoni tyrosine kinase 0.0175 0.1374 0.1715
Trypanosoma brucei polo-like protein kinase 0.0042 0.0249 0.1339
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0146 0.0414
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0024 0.0097 0.0094
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0057 0.0372 0.0819
Brugia malayi jmjC domain containing protein 0.0016 0.0027 0.0026
Mycobacterium tuberculosis Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras 0.0168 0.1313 0.2251
Toxoplasma gondii AGC kinase 0.0019 0.0049 0.0059
Echinococcus granulosus cyclin dependent kinase 0.002 0.006 0.0057
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0054 0.0125
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0198 0.1568 0.3594
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0075 0.053 0.0527
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0038 0.0027
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0024 0.0097 0.0094
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0072 0.0498 0.1972
Loa Loa (eye worm) hypothetical protein 0.0171 0.1341 0.3073
Schistosoma mansoni hypothetical protein 0.0017 0.0035 0.0024
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0464 0.2631
Mycobacterium ulcerans 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0698 0.5801 1
Plasmodium falciparum LCCL domain-containing protein 0.0018 0.0042 0.0026
Brugia malayi Glutamate receptor 1 precursor 0.0528 0.4364 1
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0223 0.022
Onchocerca volvulus Poor gastrulation protein homolog 0.0017 0.0035 0.0044
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0043 0.0253 0.025
Leishmania major protein kinase A catalytic subunit 0.0019 0.0049 0.013
Echinococcus multilocularis glutamate receptor NMDA 0.0152 0.1179 0.1176
Echinococcus multilocularis 6 phosphofructokinase 0.0111 0.0833 0.0831
Onchocerca volvulus Tyrosine kinase homolog 0.0065 0.0443 0.1764
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0249 0.0855
Brugia malayi jmjC domain containing protein 0.0016 0.0027 0.0026
Trichomonas vaginalis CMGC family protein kinase 0.0043 0.0253 0.0871
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0029 0.0136 0.0188
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0101 0.075 0.1719
Echinococcus multilocularis lipoxygenase domain containing protein 0.0018 0.0042 0.004
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0249 0.0855
Echinococcus multilocularis RUN 0.0018 0.0042 0.004
Echinococcus granulosus intermediate filament protein 0.0028 0.0125 0.0123
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0178 0.1395 0.5745
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0401 0.0486
Trypanosoma cruzi polo-like protein kinase, putative 0.0042 0.0249 0.1339
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.0833 0.3348
Loa Loa (eye worm) hypothetical protein 0.0019 0.0049 0.0112
Schistosoma mansoni glutamate receptor kainate 0.0528 0.4364 0.5489
Mycobacterium ulcerans aminopeptidase N PepN 0.0025 0.0102 0.0083
Echinococcus multilocularis tyrosine protein kinase Srms 0.0023 0.0083 0.008
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.0833 0.1032
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.0833 0.1032
Echinococcus granulosus lipoxygenase domain containing protein 0.0018 0.0042 0.004
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0043 0.0253 0.0299
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0016 0.0027 0.0025
Onchocerca volvulus Serine\/threonine kinase homolog 0.0042 0.0249 0.0948
Schistosoma mansoni dihydrofolate reductase 0.0071 0.049 0.0599
Loa Loa (eye worm) hypothetical protein 0.0025 0.0102 0.0234
Trypanosoma brucei Aminopeptidase M1, putative 0.0071 0.049 0.279
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0025 0.0102 0.0148
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0027 0.0014
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0212 0.1685 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0287
Brugia malayi jmjC domain containing protein 0.0016 0.0027 0.0026
Onchocerca volvulus 0.0028 0.0125 0.0424
Echinococcus granulosus lamin 0.0028 0.0125 0.0123
Giardia lamblia Kinase, CMGC GSK 0.0043 0.0253 0.0871
Loa Loa (eye worm) hypothetical protein 0.0016 0.0027 0.0063
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0146 0.0414
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0027 0.0063
Echinococcus granulosus glutamate receptor NMDA 0.0152 0.1179 0.1177
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0025 0.0102 0.0449
Mycobacterium ulcerans aldehyde dehydrogenase 0.0055 0.0356 0.0525
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0019 0.0049 0.0037
Echinococcus multilocularis Polycystic kidney disease protein 0.0018 0.0042 0.004
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.0833 0.4862
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.068 0.5644 0.9727
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.01 0.0734 0.1651
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0212 0.1685 0.6983
Echinococcus multilocularis receptor type guanylyl cyclase 0.0175 0.1374 0.1372
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0004 0.0001
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0027 0.012 0.0561
Giardia lamblia Kinase, PLK 0.0042 0.0249 0.0855
Brugia malayi hypothetical protein 0.0025 0.0102 0.0197
Echinococcus multilocularis tyrosine kinase 0.0175 0.1374 0.1372
Schistosoma mansoni ATP-binding cassette transporter 0.0528 0.4364 0.5489
Brugia malayi hypothetical protein 0.0018 0.0042 0.0061
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0212 0.1685 0.2872
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0178 0.1395 0.825
Echinococcus multilocularis dihydrofolate reductase 0.0071 0.049 0.0488
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0253 0.2031 0.2029
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0027 0.0025
Echinococcus granulosus bloom syndrome protein 0.0022 0.0076 0.0074
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0057 0.0372 0.2078
Schistosoma mansoni glutamate receptor kainate 0.0528 0.4364 0.5489
Echinococcus granulosus glutamate receptor 2 0.0337 0.2745 0.2743
Echinococcus granulosus tyrosine kinase 0.0175 0.1374 0.1372
Schistosoma mansoni lamin 0.0028 0.0125 0.0138
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0464 0.1827
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0019 0.0049 0.013
Schistosoma mansoni tyrosine kinase 0.0024 0.0097 0.0102
Plasmodium vivax glycogen synthase kinase 3, putative 0.0043 0.0253 0.0409
Mycobacterium ulcerans short chain dehydrogenase 0.0338 0.2752 0.4695
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0125 0.0287
Schistosoma mansoni lamin 0.0028 0.0125 0.0138
Echinococcus granulosus aminopeptidase N 0.024 0.1925 0.1923
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0046 0.028 0.1521
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0076 0.0117
Schistosoma mansoni hypothetical protein 0.0053 0.034 0.0409
Echinococcus granulosus arachidonate 5 lipoxygenase 0.005 0.0314 0.0312
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0071 0.049 0.279
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0029 0.0136 0.0133
Schistosoma mansoni lipoxygenase 0.0018 0.0042 0.0033
Loa Loa (eye worm) phosphatidylinositol 3 0.005 0.0316 0.0725
Entamoeba histolytica cell division protein kinase 2, putative 0.002 0.006 0.0115
Schistosoma mansoni tyrosine kinase 0.0096 0.0708 0.0873
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.0833 0.3348
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0071 0.049 0.279
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0249 0.0855
Brugia malayi Peptidase family M1 containing protein 0.0025 0.0102 0.0197
Echinococcus granulosus tyrosine protein kinase shark 0.0103 0.076 0.0757
Echinococcus granulosus tyrosine protein kinase Fyn 0.0024 0.0097 0.0094
Loa Loa (eye worm) glutamate receptor 0.0041 0.024 0.055
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0025 0.0102 0.0449
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0464 0.0461
Onchocerca volvulus 0.0018 0.0042 0.0074
Brugia malayi TATA binding protein associated factor 0.0025 0.0102 0.0197
Echinococcus multilocularis musashi 0.0028 0.0125 0.0122
Echinococcus multilocularis tyrosine protein kinase Blk 0.0023 0.0083 0.008
Onchocerca volvulus 0.0063 0.0427 0.1699
Toxoplasma gondii aminopeptidase N protein 0.0025 0.0102 0.015

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 7.66 Inhibition of 11beta-HSD1 (unknown origin) ChEMBL. 18314331
Log IC50 (binding) = 7.66 Inhibition of 11beta-HSD1 (unknown origin) ChEMBL. 18314331

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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