Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.2097 | 1 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.033 | 0.1493 | 0.1381 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.0167 | 0.0135 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0067 | 0.0228 | 0.01 |
Toxoplasma gondii | polyprenyl synthetase superfamily protein | 0.1059 | 0.5002 | 0.492 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0282 | 0.0282 |
Schistosoma mansoni | smad1 5 8 and | 0.0026 | 0.0033 | 0.0022 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0066 | 0.0223 | 0.0213 |
Schistosoma mansoni | smad1 5 8 and | 0.0026 | 0.0033 | 0.0022 |
Trypanosoma cruzi | solanesyl-diphosphate synthase, putative | 0.1059 | 0.5002 | 0.4937 |
Echinococcus granulosus | Smad4 | 0.0026 | 0.0033 | 0.0022 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0067 | 0.0228 | 0.01 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0385 | 0.1761 | 0.1761 |
Loa Loa (eye worm) | Smad1 | 0.0026 | 0.0033 | 0.0033 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0167 | 0.0167 |
Loa Loa (eye worm) | polyprenyl synthetase | 0.2097 | 1 | 1 |
Trypanosoma cruzi | polyprenyl synthase, putative | 0.0959 | 0.4523 | 0.4452 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0025 | 0.0026 | 0.0016 |
Brugia malayi | Polyprenyl synthetase family protein | 0.1059 | 0.5002 | 0.4986 |
Trypanosoma brucei | solanesyl-diphosphate synthase, putative | 0.1059 | 0.5002 | 0.4937 |
Toxoplasma gondii | polyprenyl synthetase superfamily protein | 0.2097 | 1 | 1 |
Trypanosoma cruzi | farnesyl pyrophosphate synthase, putative | 0.2097 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0067 | 0.0228 | 0.01 |
Echinococcus granulosus | geranylgeranyl pyrophosphate synthase | 0.0959 | 0.4523 | 0.4518 |
Leishmania major | mitochondrial DNA polymerase beta | 0.033 | 0.1493 | 0.1295 |
Schistosoma mansoni | bromodomain containing protein | 0.007 | 0.0242 | 0.0232 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0082 | 0.0072 |
Brugia malayi | MH2 domain containing protein | 0.0385 | 0.1761 | 0.1734 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0026 | 0.0033 | 0.0033 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0082 | 0.0072 |
Echinococcus multilocularis | decaprenyl diphosphate synthase subunit 1 | 0.1059 | 0.5002 | 0.4997 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.0167 | 0.0167 |
Brugia malayi | Bromodomain containing protein | 0.0042 | 0.011 | 0.0077 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0067 | 0.0228 | 0.01 |
Plasmodium falciparum | geranylgeranyl pyrophosphate synthase, putative | 0.2097 | 1 | 1 |
Echinococcus multilocularis | smad | 0.0026 | 0.0033 | 0.0022 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0082 | 0.0072 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0067 | 0.0228 | 0.01 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.011 | 0.011 |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.2097 | 1 | 0.5 |
Schistosoma mansoni | glutathione synthetase | 0.0715 | 0.3347 | 0.334 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0023 | 0.0016 | 0.0016 |
Echinococcus multilocularis | geranylgeranyl pyrophosphate synthase | 0.0959 | 0.4523 | 0.4518 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.033 | 0.1493 | 0.1381 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0026 | 0.0033 | 0.0022 |
Schistosoma mansoni | lamin | 0.0088 | 0.0331 | 0.0321 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0067 | 0.0228 | 0.01 |
Leishmania major | solanesyl-diphosphate synthase, putative | 0.1059 | 0.5002 | 0.4886 |
Leishmania major | farnesyl pyrophosphate synthase | 0.2097 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0122 | 0.0122 |
Trypanosoma brucei | farnesyl pyrophosphate synthase | 0.2097 | 1 | 1 |
Mycobacterium tuberculosis | Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate | 0.0715 | 0.3347 | 0.2814 |
Brugia malayi | Bromodomain containing protein | 0.0083 | 0.0304 | 0.0273 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0757 | 0.3548 | 0.3542 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0104 | 0.0104 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0043 | 0.0111 | 0.0101 |
Echinococcus granulosus | decaprenyl diphosphate synthase subunit 1 | 0.1059 | 0.5002 | 0.4997 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0067 | 0.0228 | 0.01 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0047 | 0.0134 | 0.0102 |
Echinococcus multilocularis | lamin dm0 | 0.0088 | 0.0331 | 0.0321 |
Echinococcus multilocularis | musashi | 0.0088 | 0.0331 | 0.0321 |
Mycobacterium tuberculosis | Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) | 0.0715 | 0.3347 | 0.2814 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.0085 | 0.0052 |
Trypanosoma cruzi | farnesyl pyrophosphate synthase | 0.2097 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0088 | 0.0331 | 0.0321 |
Mycobacterium ulcerans | geranylgeranyl pyrophosphate synthase | 0.2097 | 1 | 1 |
Mycobacterium tuberculosis | Probable polyprenyl-diphosphate synthase GrcC1 (polyprenyl pyrophosphate synthetase) | 0.0344 | 0.1562 | 0.0885 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.0331 | 0.0331 |
Echinococcus multilocularis | farnesyl pyrophosphate synthase | 0.2097 | 1 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0025 | 0.0026 | 0.0016 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0026 | 0.0033 | 0.0022 |
Onchocerca volvulus | 0.0088 | 0.0331 | 0.5 | |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.0167 | 0.0135 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0043 | 0.0111 | 0.0101 |
Brugia malayi | intermediate filament protein | 0.0088 | 0.0331 | 0.03 |
Mycobacterium ulcerans | polyprenyl diphosphate synthetase, GrcC1 | 0.1059 | 0.5002 | 0.4602 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0088 | 0.0331 | 0.0331 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.004 | 0.0097 | 0.0087 |
Entamoeba histolytica | geranylgeranyl pyrophosphate synthase, putative | 0.1059 | 0.5002 | 1 |
Mycobacterium ulcerans | polyprenyl synthetase IdsB | 0.0715 | 0.3347 | 0.2814 |
Schistosoma mansoni | farnesyl pyrophosphate synthase | 0.2097 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0067 | 0.0228 | 0.01 |
Treponema pallidum | octaprenyl-diphosphate synthase | 0.0959 | 0.4523 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0082 | 0.0072 |
Wolbachia endosymbiont of Brugia malayi | geranylgeranyl pyrophosphate synthase | 0.1059 | 0.5002 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0156 | 0.0657 | 0.0535 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0056 | 0.0178 | 0.0049 |
Schistosoma mansoni | trans-prenyltransferase | 0.1059 | 0.5002 | 0.4997 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0066 | 0.0223 | 0.0213 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0026 | 0.0033 | 0.0022 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0088 | 0.0331 | 0.03 |
Mycobacterium tuberculosis | Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) | 0.0715 | 0.3347 | 0.2814 |
Schistosoma mansoni | lamin | 0.0088 | 0.0331 | 0.0321 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0111 | 0.0111 |
Mycobacterium ulcerans | geranylgeranyl pyrophosphate synthase | 0.2097 | 1 | 1 |
Trypanosoma cruzi | solanesyl-diphosphate synthase, putative | 0.1059 | 0.5002 | 0.4937 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0026 | 0.0033 | 0.0022 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0067 | 0.0228 | 0.01 |
Echinococcus granulosus | smad | 0.0026 | 0.0033 | 0.0022 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0133 | 0.0133 |
Leishmania major | polyprenyl synthase, putative | 0.0959 | 0.4523 | 0.4396 |
Brugia malayi | PHD-finger family protein | 0.0027 | 0.0038 | 0.0006 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0053 | 0.0159 | 0.003 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0104 | 0.0104 |
Loa Loa (eye worm) | geranylgeranyl pyrophosphate synthetase | 0.0959 | 0.4523 | 0.4523 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0757 | 0.3548 | 0.3542 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0067 | 0.0228 | 0.01 |
Echinococcus granulosus | farnesyl pyrophosphate synthase | 0.2097 | 1 | 1 |
Schistosoma mansoni | Smad4 | 0.0026 | 0.0033 | 0.0022 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0067 | 0.0228 | 0.01 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0047 | 0.0134 | 0.0134 |
Echinococcus granulosus | prenyl decaprenyl diphosphate synthase | 0.0715 | 0.3347 | 0.334 |
Schistosoma mansoni | smad | 0.0026 | 0.0033 | 0.0022 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0026 | 0.0033 | 0.0033 |
Mycobacterium tuberculosis | Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) | 0.2097 | 1 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.004 | 0.0097 | 0.0087 |
Trypanosoma cruzi | polyprenyl synthase, putative | 0.0959 | 0.4523 | 0.4452 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0323 | 0.0323 |
Entamoeba histolytica | bifunctional short chain isoprenyl diphosphate synthase, putative | 0.0715 | 0.3347 | 0.6636 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0026 | 0.0033 | 0.0022 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0067 | 0.0228 | 0.01 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0061 | 0.02 | 0.0072 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0085 | 0.0074 |
Trypanosoma cruzi | solanesyl-diphosphate synthase | 0.1059 | 0.5002 | 0.4937 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0156 | 0.0657 | 0.0535 |
Schistosoma mansoni | intermediate filament proteins | 0.0088 | 0.0331 | 0.0321 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0016 | 0.0006 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0067 | 0.0228 | 0.01 |
Mycobacterium leprae | PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) | 0.1059 | 0.5002 | 0.5 |
Echinococcus multilocularis | prenyl (decaprenyl) diphosphate synthase | 0.0715 | 0.3347 | 0.334 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0067 | 0.0228 | 0.01 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.033 | 0.1493 | 0.1381 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0082 | 0.0049 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0067 | 0.0228 | 0.01 |
Schistosoma mansoni | geranylgeranyl pyrophosphate synthase | 0.0959 | 0.4523 | 0.4518 |
Echinococcus multilocularis | Smad4 | 0.0026 | 0.0033 | 0.0022 |
Trichomonas vaginalis | geranylgeranyl diphosphate synthase, putative | 0.2097 | 1 | 0.5 |
Schistosoma mansoni | smad1 5 8 and | 0.0026 | 0.0033 | 0.0022 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0385 | 0.1761 | 0.1761 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0156 | 0.0657 | 0.0439 |
Chlamydia trachomatis | geranylgeranyl pyrophosphate synthase | 0.0715 | 0.3347 | 0.5 |
Echinococcus multilocularis | lamin | 0.0088 | 0.0331 | 0.0321 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0757 | 0.3548 | 0.3542 |
Giardia lamblia | Farnesyl diphosphate synthase | 0.2097 | 1 | 0.5 |
Onchocerca volvulus | 0.0088 | 0.0331 | 0.5 | |
Echinococcus granulosus | intermediate filament protein | 0.0088 | 0.0331 | 0.0321 |
Plasmodium vivax | geranylgeranyl pyrophosphate synthase | 0.2097 | 1 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0025 | 0.0026 | 0.0016 |
Brugia malayi | geranylgeranyl pyrophosphate synthetase | 0.0959 | 0.4523 | 0.4506 |
Loa Loa (eye worm) | intermediate filament protein | 0.0088 | 0.0331 | 0.0331 |
Echinococcus granulosus | lamin dm0 | 0.0088 | 0.0331 | 0.0321 |
Entamoeba histolytica | geranylgeranyl pyrophosphate synthetase, putative | 0.1059 | 0.5002 | 1 |
Loa Loa (eye worm) | polyprenyl synthetase | 0.1059 | 0.5002 | 0.5002 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0085 | 0.0085 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 21.1923 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.