Detailed information for compound 543044

Basic information

Technical information
  • TDR Targets ID: 543044
  • Name: [(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-acetoxy-1 0,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-ox o-3-vinyl-5,6,6a,8,9,10-hexahydro-2H-benzo[f] chromen-6-yl] 4-methylpentanoate hydrochlorid e
  • MW: 545.105 | Formula: C28H45ClO8
  • H donors: 2 H acceptors: 5 LogP: 4 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: C=C[C@@]1(C)CC(=O)[C@]2([C@@](O1)(C)[C@@H](OC(=O)C)[C@H]([C@@H]1[C@]2(C)[C@@H](O)CCC1(C)C)OC(=O)CCC(C)C)O.Cl
  • InChi: 1S/C28H44O8.ClH/c1-10-25(7)15-19(31)28(33)26(8)18(30)13-14-24(5,6)22(26)21(35-20(32)12-11-16(2)3)23(34-17(4)29)27(28,9)36-25;/h10,16,18,21-23,30,33H,1,11-15H2,2-9H3;1H/t18-,21-,22-,23-,25-,26-,27+,28-;/m0./s1
  • InChiKey: LNEICJSEZPSKSJ-RPBMHHKSSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-methylpentanoic acid [(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-acetoxy-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyl-5,6,6a,8,9,10-hexahydro-2H-benzo[f][1]benzopyran-6-yl] ester hydrochloride
  • [(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-acetyloxy-3-ethenyl-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-6-yl] 4-methylpentanoate hydrochloride
  • 4-methylvaleric acid [(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-acetoxy-10,10b-dihydroxy-1-keto-3,4a,7,7,10a-pentamethyl-3-vinyl-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-6-yl] ester hydrochloride
  • 4-methylpentanoic acid [(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-acetoxy-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyl-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-6-yl] ester hydrochloride
  • 6-(3-Dimethylaminopropionyl)forskolin hydrochloride
  • Colforsin dapropate hydrochloride
  • NKH477
  • beta-Alanine, N,N-dimethyl-, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho(2,1-b)pyran-6-yl ester, hydrochloride
  • beta-Alanine, N,N-dimethyl-, 5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho(2,1-b)pyran-6-yl ester, hydrochloride, (3R-(3-alpha,4a-beta,5-beta,6-beta,6a-alpha,10-alpha,10a-beta,10b-alpha))-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0016 0.0101 0.0064
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0074 0.0185
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0159 0.0144
Echinococcus multilocularis solute carrier family 22 0.0014 0.0074 0.0012
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0551 0.0663
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0428 0.0495
Entamoeba histolytica Ran family GTPase 0.0021 0.021 0.2339
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0074 0.0037
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0016 0.0101 0.0064
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0366 0.0508
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0159 0.0144
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0074 0.0185
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0074 0.0185
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.0074 0.0012
Loa Loa (eye worm) hypothetical protein 0.0455 0.9339 0.9336
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0437 0.2121
Echinococcus granulosus low density lipoprotein receptor ldl 0.0019 0.0168 0.014
Loa Loa (eye worm) hypothetical protein 0.0014 0.0074 0.0037
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0551 0.1022
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0019 0.0168 0.014
Echinococcus multilocularis expressed protein 0.0016 0.0101 0.0049
Mycobacterium ulcerans hypothetical protein 0.0156 0.3043 1
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0136 0.0105
Mycobacterium ulcerans beta-lactamase 0.0037 0.0551 0.181
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0016 0.0101 0.0328
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0769 0.0735
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0159 0.064
Brugia malayi Importin beta-1 subunit 0.0028 0.0366 0.0311
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0016 0.0101 0.0044
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0295 0.5981 1
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0429 0.0404
Toxoplasma gondii facilitative glucose transporter GT1 0.0102 0.1912 0.3201
Toxoplasma gondii protein kinase, putative 0.0287 0.5816 1
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0074 0.0243
Schistosoma mansoni ran 0.0021 0.021 0.0197
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0521 0.0757
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0791 0.0739
Echinococcus granulosus snurportin 1 0.0301 0.61 0.823
Trichomonas vaginalis myo-inositol transporter, putative 0.0014 0.0074 0.0185
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0016 0.0101 0.0049
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0907 0.1148
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0019 0.0168 0.0132
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.0159 0.0523
Trichomonas vaginalis sugar transport protein, putative 0.0014 0.0074 0.0185
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0769 0.096
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0016 0.0101 0.0064
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0429 0.0404
Leishmania major hypothetical protein, conserved 0.0078 0.1408 0.2258
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0074 0.0185
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0192 0.0814
Loa Loa (eye worm) hypothetical protein 0.0016 0.0101 0.0064
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0551 0.1539
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0429 0.0404
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.016 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0053 0.0887 0.1741
Plasmodium falciparum mitogen-activated protein kinase 2 0.0164 0.3229 0.3595
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.016 0.0145
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0251 0.0201
Loa Loa (eye worm) hypothetical protein 0.0021 0.021 0.0174
Plasmodium falciparum glutathione reductase 0.0053 0.0887 0.0926
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0521 0.0757
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0074 0.0185
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0074 0.0185
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0074 0.0185
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.016 0.0098
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0159 0.0097
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0251 0.0298
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0769 0.096
Schistosoma mansoni protein kinase 0.0031 0.0428 0.0495
Schistosoma mansoni hypothetical protein 0.0335 0.6818 0.9209
Brugia malayi hypothetical protein 0.0148 0.2879 0.2838
Loa Loa (eye worm) hypothetical protein 0.0078 0.1408 0.1376
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0251 0.1129
Echinococcus multilocularis solute carrier family 22 0.0014 0.0074 0.0012
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0016 0.0101 0.0049
Plasmodium vivax importin-beta 2, putative 0.0028 0.0366 0.0333
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0016 0.0101 0.0049
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0565 0.0682
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0428 0.0495
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0428 0.2076
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.1012 0.3326
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0074 0.0185
Schistosoma mansoni eyes absent homolog 0.0086 0.1585 0.2072
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0437 0.0614
Schistosoma mansoni hypothetical protein 0.0021 0.021 0.0197
Loa Loa (eye worm) hypothetical protein 0.0019 0.0168 0.0132
Toxoplasma gondii histone lysine methyltransferase SET1 0.0106 0.1998 0.3351
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0016 0.0101 0.0044
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.016 0.1271
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.021 0.0197
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0016 0.0101 0.0328
Plasmodium falciparum protein kinase 6 0.0432 0.8851 1
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0521 0.051
Onchocerca volvulus 0.0019 0.0168 0.0101
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.021 0.0197
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0251 0.0253
Brugia malayi major facilitator superfamily protein 0.0014 0.0074 0.0017
Brugia malayi mbt repeat family protein 0.0047 0.0769 0.0717
Brugia malayi beta-lactamase family protein 0.0037 0.0551 0.0497
Loa Loa (eye worm) hypothetical protein 0.0016 0.0101 0.0064
Schistosoma mansoni rab6-interacting 0.0021 0.021 0.0197
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.016 0.0129
Schistosoma mansoni sugar transporter 0.0014 0.0074 0.0012
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0058 0.0995 0.1269
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0159 0.0148
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0016 0.0101 0.0049
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.021 0.0229
Brugia malayi hypothetical protein 0.0014 0.0074 0.0017
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0363 0.7398 1
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0074 0.0017
Mycobacterium tuberculosis Conserved protein 0.0037 0.0551 0.1022
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0428 0.0495
Echinococcus multilocularis solute carrier family 22 0.0014 0.0074 0.0012
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.0159 0.0523
Loa Loa (eye worm) hypothetical protein 0.0019 0.0168 0.0132
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0118 0.2264 0.2999
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.016 0.0145
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0014 0.0074 0.0012
Leishmania major glucose transporter, lmgt1 0.0032 0.0437 0.0614
Schistosoma mansoni hypothetical protein 0.0292 0.5905 0.7965
Onchocerca volvulus 0.0037 0.0551 0.0515
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0551 0.0497
Echinococcus granulosus basement membrane specific heparan sulfate 0.0019 0.0168 0.014
Loa Loa (eye worm) hypothetical protein 0.0019 0.0168 0.0132
Brugia malayi Thioredoxin reductase 0.0053 0.0887 0.0835
Loa Loa (eye worm) histone methyltransferase 0.0017 0.0137 0.01
Onchocerca volvulus 0.0019 0.0168 0.0101
Mycobacterium tuberculosis Conserved protein 0.0037 0.0551 0.1022
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0016 0.0101 0.0049
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0019 0.0168 0.014
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0415 0.0477
Trypanosoma brucei PAB1-binding protein , putative 0.0078 0.1408 0.2258
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0074 0.0185
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0948 0.0914
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0074 0.0243
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0551 0.0807
Schistosoma mansoni cpg binding protein 0.0056 0.0948 0.1203
Leishmania major importin beta-1 subunit, putative 0.0023 0.0254 0.0304
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0074 0.0185
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0019 0.0168 0.014
Loa Loa (eye worm) hypothetical protein 0.0021 0.021 0.0174
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.021 0.0229
Echinococcus granulosus solute carrier family 22 0.0014 0.0074 0.0012
Loa Loa (eye worm) hypothetical protein 0.0031 0.0428 0.0393
Mycobacterium tuberculosis Probable reductase 0.0121 0.2313 0.4798
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.1912 0.2519
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0428 0.0495
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0016 0.0101 0.0328
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.5981 1
Loa Loa (eye worm) glutathione reductase 0.0053 0.0887 0.0853
Brugia malayi RNA, U transporter 1 0.008 0.1459 0.141
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0019 0.0168 0.0112
Leishmania major glucose transporter, lmgt3 0.0032 0.0437 0.0614
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.5981 1
Schistosoma mansoni hypothetical protein 0.0015 0.0095 0.0041
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0429 0.0617
Onchocerca volvulus 0.0037 0.0551 0.0515
Brugia malayi hypothetical protein 0.0078 0.1408 0.1359
Echinococcus multilocularis Protein lozenge 0.0057 0.0973 0.1238
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.1408 0.152
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0016 0.0101 0.0328
Loa Loa (eye worm) hypothetical protein 0.0014 0.0074 0.0037
Onchocerca volvulus Arrow homolog 0.0019 0.0168 0.0101
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0074 0.0185
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0159 0.0144
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0074 0.0243
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0074 0.0185
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0159 0.0144
Echinococcus granulosus thioredoxin glutathione reductase 0.0053 0.0887 0.1121
Schistosoma mansoni hypothetical protein 0.0033 0.0469 0.0551
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.1912 0.2519
Toxoplasma gondii ABC1 family protein 0.0037 0.0551 0.083
Brugia malayi G-protein alpha subunit 0.0016 0.0101 0.0044
Onchocerca volvulus Terribly reduced optic lobes homolog 0.0019 0.0168 0.0101
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0159 0.0144
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.016 0.0104
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0769 0.096
Loa Loa (eye worm) calcium binding EGF domain-containing protein 0.0019 0.0168 0.0132
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0019 0.0168 0.0112
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0016 0.0101 0.0044
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0019 0.0168 0.0101
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.1912 0.2519
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0769 0.075
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0437 0.0614
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.1912 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.016 0.0145
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0551 0.1022
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0159 0.0144
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0551 0.181
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0164 0.3229 0.5495
Trypanosoma brucei glucose transporter 2A 0.0032 0.0437 0.0614
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0437 0.0614
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.021 0.0229
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0363 0.7398 1
Brugia malayi hypothetical protein 0.0455 0.9339 0.9335
Mycobacterium tuberculosis Probable oxidoreductase 0.0134 0.2597 0.5405
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0121 0.2313 0.8828
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0134 0.2597 0.5405
Plasmodium falciparum glutathione reductase 0.0018 0.0159 0.0097
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0251 0.0299
Leishmania major hypothetical protein, conserved 0.0037 0.0551 0.0807
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.1912 0.2519
Loa Loa (eye worm) runx1 0.0057 0.0973 0.094
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0159 0.0103
Loa Loa (eye worm) hypothetical protein 0.0014 0.0074 0.0037
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0074 0.0185
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.0074 0.0012
Leishmania major trypanothione reductase 0.0053 0.0887 0.1376
Schistosoma mansoni sugar transporter 0.0014 0.0074 0.0012
Loa Loa (eye worm) hypothetical protein 0.0016 0.0101 0.0064
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0159 0.0144
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0254 0.1146
Loa Loa (eye worm) hypothetical protein 0.0048 0.0791 0.0757
Echinococcus granulosus low density lipoprotein receptor ldl 0.0019 0.0168 0.014
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.021 0.0236
Trypanosoma brucei glucose transporter, putative 0.0032 0.0437 0.0614
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0236 0.4741 1
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0016 0.0101 0.0064
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.1408 0.2258
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0251 0.0201
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0254 0.0304
Brugia malayi Sugar transporter family protein 0.0102 0.1912 0.1866
Schistosoma mansoni hypothetical protein 0.0301 0.61 0.823
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.1012 0.0961
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0016 0.0101 0.0049
Schistosoma mansoni sugar transporter 0.0014 0.0074 0.0012
Echinococcus granulosus solute carrier family 22 0.0014 0.0074 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0074 0.0185
Brugia malayi hypothetical protein 0.0021 0.021 0.0154
Echinococcus granulosus cpg binding protein 0.0059 0.1015 0.1295
Brugia malayi Low-density lipoprotein receptor-related protein, putative 0.0019 0.0168 0.0112
Plasmodium falciparum importin beta, putative 0.0028 0.0366 0.0333
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.0929 0.0895
Brugia malayi Calcium binding EGF domain containing protein 0.0019 0.0168 0.0112
Schistosoma mansoni hypothetical protein 0.0015 0.0095 0.0041
Schistosoma mansoni glucose transport protein 0.0102 0.1912 0.2519
Plasmodium falciparum protein kinase 7 0.0287 0.5816 0.6542
Loa Loa (eye worm) hypothetical protein 0.0014 0.0074 0.0037
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0074 0.0185
Loa Loa (eye worm) hypothetical protein 0.0014 0.0074 0.0037
Leishmania major glucose transporter, lmgt2 0.0032 0.0437 0.0614
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0159 0.0144
Loa Loa (eye worm) hypothetical protein 0.0014 0.0074 0.0037
Plasmodium vivax CDK-related protein kinase 6, putative 0.0432 0.8851 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.2711 0.4465
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0159 0.0144
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.021 0.0155
Brugia malayi Doublecortin family protein 0.0021 0.021 0.0154
Schistosoma mansoni sugar transporter 0.0014 0.0074 0.0012
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0366 0.041
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0134 0.2597 0.5405
Onchocerca volvulus 0.0047 0.0769 0.075
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0907 0.0855
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0251 0.0195
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0388 0.044
Loa Loa (eye worm) hypothetical protein 0.0016 0.0101 0.0064
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0074 0.0037
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0428 0.0374
Schistosoma mansoni protein kinase 0.0031 0.0428 0.0495
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0551 0.0663
Loa Loa (eye worm) hypothetical protein 0.0014 0.0074 0.0037
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0179 0.0224
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0437 0.2121
Entamoeba histolytica hypothetical protein 0.0038 0.0565 1
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0565 0.0682
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0251 0.0253
Trypanosoma brucei glucose transporter, putative 0.0032 0.0437 0.0614
Loa Loa (eye worm) hypothetical protein 0.0086 0.1585 0.1553
Schistosoma mansoni hypothetical protein 0.0035 0.0506 0.0602
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0159 0.0097
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0121 0.2313 0.4798
Loa Loa (eye worm) doublecortin family protein 0.0021 0.021 0.0174
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0074 0.0017
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0301 0.61 0.6086
Schistosoma mansoni protein kinase 0.0031 0.0428 0.0495
Brugia malayi hypothetical protein 0.0014 0.0074 0.0017
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0159 0.064
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0437 0.2121
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0121 0.2313 0.4798
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0551 0.0516
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0019 0.0168 0.014
Loa Loa (eye worm) hypothetical protein 0.0014 0.0074 0.0037
Trypanosoma brucei glucose transporter, putative 0.0032 0.0437 0.0614
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0121 0.2313 0.4798
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0016 0.0101 0.0049
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0137 0.0098
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0415 0.0477
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0551 0.2731
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0159 0.0148
Echinococcus granulosus solute carrier family 22 0.0014 0.0074 0.0012
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0254 0.1146
Loa Loa (eye worm) thioredoxin reductase 0.0053 0.0887 0.0853
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0388 0.044
Treponema pallidum NADH oxidase 0.0018 0.0159 0.9955
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0159 0.0182
Plasmodium falciparum thioredoxin reductase 0.0053 0.0887 0.0926
Schistosoma mansoni hypothetical protein 0.0015 0.0095 0.0041
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0164 0.3229 0.3595
Trypanosoma brucei glucose transporter, putative 0.0032 0.0437 0.0614
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0251 0.0824
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0437 0.0614
Loa Loa (eye worm) hypothetical protein 0.0148 0.2879 0.2853
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0551 0.0807
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.1912 0.2519
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0907 0.1148
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.016 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0551 0.0516
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0159 0.0144
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0428 0.0495
Echinococcus multilocularis low density lipoprotein receptor protein 0.0019 0.0168 0.014
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0095 0.0039
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0646 0.0969
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.016 0.0124
Echinococcus granulosus geminin 0.0335 0.6818 0.9209
Loa Loa (eye worm) hypothetical protein 0.0086 0.1585 0.1553
Trypanosoma brucei glucose transporter 1E 0.0032 0.0437 0.0614
Schistosoma mansoni hypothetical protein 0.0038 0.0565 0.0682
Trypanosoma brucei glucose transporter, putative 0.0032 0.0437 0.0614
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.1912 0.2519
Schistosoma mansoni importin beta-1 0.0028 0.0366 0.041
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0769 0.096
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.1012 0.3326
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0428 0.06
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0074 0.0185
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.0159 0.6349
Schistosoma mansoni GTP-binding protein alpha subunit 0.0016 0.0101 0.0049
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0551 0.1022
Loa Loa (eye worm) hypothetical protein 0.0037 0.0551 0.0516
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0074 0.0185
Schistosoma mansoni rab6-interacting 0.0021 0.021 0.0197
Schistosoma mansoni GTP-binding protein alpha subunit 0.0016 0.0101 0.0049
Echinococcus multilocularis solute carrier family 22 0.0014 0.0074 0.0012
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0437 0.0614
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0521 0.0757
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0366 0.0494
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0074 0.0185
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0179 0.0224
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0074 0.0185
Loa Loa (eye worm) hypothetical protein 0.0031 0.0415 0.038
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0019 0.0168 0.0132
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.016 0.0145
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0074 0.0185
Entamoeba histolytica protein kinase, putative 0.0031 0.0428 0.7047
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0019 0.0168 0.0112
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0058 0.0995 0.1269
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0551 0.0807
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0137 0.0098
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.0159 0.0523
Plasmodium vivax hexose transporter 0.0102 0.1912 0.2094
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0251 0.0299
Brugia malayi Sugar transporter family protein 0.0014 0.0074 0.0017
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0074 0.0185
Echinococcus granulosus solute carrier family 22 0.0014 0.0074 0.0012
Leishmania major GTP-binding protein, putative 0.0021 0.021 0.0229
Loa Loa (eye worm) hypothetical protein 0.0014 0.0074 0.0037
Onchocerca volvulus 0.0016 0.0101 0.0029
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0095 0.0041
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0159 0.0144
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0074 0.0185
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0251 0.0299
Entamoeba histolytica hypothetical protein 0.0023 0.0251 0.3226
Plasmodium vivax ataxin-2 like protein, putative 0.0078 0.1408 0.152
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0791 0.0739
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0159 0.0128
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0159 0.0144
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0016 0.0101 0.0328
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0074 0.0185
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0019 0.0168 0.0112
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0363 0.7398 0.7383
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0095 0.0041
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0646 0.0969
Loa Loa (eye worm) hypothetical protein 0.0037 0.0551 0.0516
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0428 0.0495
Onchocerca volvulus 0.0455 0.9339 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.1012 0.1292
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0429 0.0617
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0016 0.0101 0.0049
Loa Loa (eye worm) hypothetical protein 0.0019 0.0168 0.0132
Trichomonas vaginalis ran, putative 0.0021 0.021 0.0909
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.021 0.0173
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0132 0.0076
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0016 0.0101 0.0044
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.021 0.0197
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0551 0.2731
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0415 0.0977
Loa Loa (eye worm) hypothetical protein 0.0037 0.0551 0.0516
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0019 0.0168 0.014
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.0887 0.1376
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0415 0.0477
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.019 0.3776 0.506
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0074 0.0185
Echinococcus granulosus RUN 0.0021 0.021 0.0197
Loa Loa (eye worm) G protein alpha subunit 3 0.0016 0.0101 0.0064
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0646 0.0969
Brugia malayi hypothetical protein 0.0038 0.0565 0.0512
Onchocerca volvulus 0.0021 0.021 0.0146
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0019 0.0168 0.0112
Echinococcus granulosus expressed protein 0.0016 0.0101 0.0049
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.3043 0.6362
Schistosoma mansoni glucose transport protein 0.0102 0.1912 0.2519
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.0074 0.0012
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0159 0.0144
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0019 0.0168 0.0132
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0907 0.1148
Loa Loa (eye worm) hypothetical protein 0.0014 0.0074 0.0037
Echinococcus multilocularis General substrate transporter 0.0087 0.1611 0.2109
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0429 0.0404
Toxoplasma gondii exonuclease III APE 0.0018 0.016 0.0149
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0428 0.0495
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0019 0.0168 0.0112
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0074 0.0017
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0251 0.5182
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.021 0.0155
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0016 0.0101 0.0044
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0074 0.0185
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0074 0.0185
Mycobacterium tuberculosis Probable dehydrogenase 0.0121 0.2313 0.4798
Mycobacterium leprae Probable lipase LipE 0.0037 0.0551 0.1539
Onchocerca volvulus 0.0016 0.0101 0.0029
Loa Loa (eye worm) hypothetical protein 0.0455 0.9339 0.9336
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.1912 0.2519
Schistosoma mansoni polycystin 1-related 0.0021 0.021 0.0197
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.016 0.0643
Entamoeba histolytica hypothetical protein 0.0038 0.0565 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0074 0.0185
Toxoplasma gondii thioredoxin reductase 0.0053 0.0887 0.1415
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0016 0.0101 0.0049
Trypanosoma brucei glucose transporter, putative 0.0032 0.0437 0.0614
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0551 0.181
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0363 0.7398 0.7388
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0074 0.0185
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0366 0.0494
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0016 0.0101 0.0328
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.016 0.0098
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0437 0.0614
Loa Loa (eye worm) hypothetical protein 0.0014 0.0074 0.0037
Echinococcus granulosus General substrate transporter 0.0087 0.1611 0.2109
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0429 0.0617
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.021 0.0154
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0159 0.0128
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0019 0.0168 0.014
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0791 0.0757
Loa Loa (eye worm) hypothetical protein 0.0014 0.0074 0.0037
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0506 0.0602
Echinococcus multilocularis RUN 0.0021 0.021 0.0197
Brugia malayi beta-lactamase 0.0037 0.0551 0.0497
Echinococcus granulosus importin subunit beta 1 0.0028 0.0366 0.041
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0646 0.0969
Echinococcus granulosus low density lipoprotein receptor protein 0.0019 0.0168 0.014
Loa Loa (eye worm) hypothetical protein 0.0014 0.0074 0.0037
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.016 0.0525
Echinococcus multilocularis thioredoxin glutathione reductase 0.0053 0.0887 0.1121
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0251 0.0253
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0437 0.2121
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.021 0.0154
Trichomonas vaginalis glucose transporter, putative 0.0014 0.0074 0.0185
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0428 0.0495
Brugia malayi basement membrane proteoglycan precursor 0.0019 0.0168 0.0112
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0437 0.2121
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0551 0.2731
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0095 0.0039
Leishmania major mitochondrial DNA polymerase beta 0.0295 0.5981 1
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0415 0.6762
Onchocerca volvulus 0.0019 0.0168 0.0101
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0469 0.0415
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0363 0.7398 1
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0019 0.0168 0.014
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0551 0.1022
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0159 0.0144
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0487 1 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0074 0.0185
Plasmodium falciparum hexose transporter 0.0102 0.1912 0.2094
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0159 0.0128
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0521 0.0779
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0565 0.0682
Mycobacterium ulcerans sugar transporter 0.0014 0.0074 0.0243
Loa Loa (eye worm) hypothetical protein 0.0025 0.0295 0.0259
Loa Loa (eye worm) hypothetical protein 0.0033 0.0469 0.0434
Loa Loa (eye worm) hypothetical protein 0.0019 0.0168 0.0132
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0837 0.1292
Brugia malayi enteropeptidase precursor 0.0019 0.0168 0.0112
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0134 0.2597 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0074 0.0185
Entamoeba histolytica hypothetical protein 0.0038 0.0565 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0074 0.0185
Schistosoma mansoni lipoxygenase 0.0021 0.021 0.0197
Mycobacterium ulcerans lipase LipD 0.0037 0.0551 0.181
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0769 0.096
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0551 0.2731
Onchocerca volvulus 0.0019 0.0168 0.0101
Echinococcus granulosus Low density lipoprotein receptor class A cysteine rich 0.0019 0.0168 0.014
Echinococcus granulosus GPCR family 2 0.0015 0.0095 0.0041
Loa Loa (eye worm) hypothetical protein 0.0019 0.0168 0.0132
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0074 0.0185
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0551 0.0543
Entamoeba histolytica hypothetical protein 0.0038 0.0565 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0074 0.0185
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0415 0.036
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0074 0.0185
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0551 0.0663
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.0074 0.0012
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.021 0.3973
Toxoplasma gondii LsmAD domain-containing protein 0.0078 0.1408 0.2323
Echinococcus multilocularis GPCR, family 2 0.0015 0.0095 0.0041
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0551 0.1022
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0016 0.0101 0.0049
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0429 0.0404
Mycobacterium ulcerans hypothetical protein 0.0037 0.0551 0.181
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0059 0.1012 0.201
Schistosoma mansoni glucose transporter 0.0014 0.0074 0.0012
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0019 0.0168 0.014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0363 0.7398 1
Toxoplasma gondii hypothetical protein 0.0048 0.0775 0.122
Trypanosoma cruzi hexose transporter 0.0032 0.0437 0.0614
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0019 0.0168 0.014
Loa Loa (eye worm) hypothetical protein 0.0019 0.0168 0.0132
Schistosoma mansoni hypothetical protein 0.0102 0.1912 0.2519
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.021 0.0197
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0016 0.0101 0.0049
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0059 0.1012 0.1292
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0016 0.0101 0.0049
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0016 0.0101 0.0044
Loa Loa (eye worm) hypothetical protein 0.0023 0.0251 0.0215
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0102 0.1912 0.2519
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0363 0.7398 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0095 0.0059
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0506 0.0602
Loa Loa (eye worm) hypothetical protein 0.0054 0.0907 0.0874
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0429 0.0404
Loa Loa (eye worm) hypothetical protein 0.0014 0.0074 0.0037
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0769 0.096
Loa Loa (eye worm) hypothetical protein 0.0016 0.0101 0.0064
Loa Loa (eye worm) hypothetical protein 0.0019 0.0168 0.0132
Loa Loa (eye worm) hypothetical protein 0.0031 0.0415 0.038
Loa Loa (eye worm) sugar transporter 0.0102 0.1912 0.1882
Onchocerca volvulus 0.0148 0.2879 0.3028
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0363 0.7398 1
Schistosoma mansoni hypothetical protein 0.0335 0.6818 0.9209
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.016 0.0129
Loa Loa (eye worm) hypothetical protein 0.0028 0.0366 0.033
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0251 0.0253
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.0159 0.2496
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0019 0.0168 0.0112
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0251 0.0824
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0551 0.0663
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0016 0.0101 0.0049
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.021 0.0154
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0363 0.7398 1
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0019 0.0168 0.014
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0437 0.2121
Plasmodium falciparum thioredoxin reductase 0.0018 0.0159 0.0097
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0016 0.0101 0.0049
Echinococcus granulosus endonuclease exonuclease phosphatase 0.019 0.3776 0.506
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.021 0.0197
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0521 0.051
Brugia malayi Cam kinase protein 1 0.0031 0.0428 0.0374
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.016 0.2517
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0074 0.0185
Leishmania major protein kinase, putative 0.0031 0.0428 0.06
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0551 0.1022
Brugia malayi CUB domain containing protein 0.0019 0.0168 0.0112
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0159 0.0144
Loa Loa (eye worm) hypothetical protein 0.0037 0.0551 0.0516
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0429 0.0404
Brugia malayi beta-lactamase family protein 0.0037 0.0551 0.0497
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0251 0.0308
Onchocerca volvulus 0.0021 0.021 0.0146
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0016 0.0101 0.0049
Loa Loa (eye worm) hypothetical protein 0.0019 0.0168 0.0132
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.1408 0.152
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.021 0.0197
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0019 0.0168 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0074 0.0185
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0074 0.0185
Loa Loa (eye worm) sugar transporter 0.0014 0.0074 0.0037
Schistosoma mansoni lipoxygenase 0.0058 0.0995 0.1269
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0016 0.0101 0.0049
Schistosoma mansoni cpg binding protein 0.0059 0.1015 0.1295
Brugia malayi hypothetical protein 0.0086 0.1585 0.1536
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0016 0.0101 0.0049
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0428 0.0393
Brugia malayi hypothetical protein 0.0014 0.0074 0.0017
Loa Loa (eye worm) hypothetical protein 0.0019 0.0168 0.0132
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0551 0.1022
Trypanosoma brucei glucose transporter, putative 0.0032 0.0437 0.0614
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0016 0.0101 0.0049
Schistosoma mansoni cpg binding protein 0.0059 0.1015 0.1295
Brugia malayi Sugar transporter family protein 0.0014 0.0074 0.0017
Echinococcus multilocularis geminin 0.0335 0.6818 0.9209
Echinococcus multilocularis snurportin 1 0.0301 0.61 0.823
Entamoeba histolytica protein kinase, putative 0.0031 0.0428 0.7047
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0074 0.0185
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.021 0.0197
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.021 0.0197
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0254 0.1146
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0016 0.0101 0.0044
Schistosoma mansoni lozenge 0.0057 0.0973 0.1238
Loa Loa (eye worm) MBCTL1 0.0054 0.0907 0.0874
Schistosoma mansoni ap endonuclease 0.0018 0.016 0.0129
Plasmodium vivax glutathione reductase, putative 0.0053 0.0887 0.0926
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0769 0.096
Trichomonas vaginalis esterase, putative 0.0037 0.0551 0.2731
Loa Loa (eye worm) hypothetical protein 0.0037 0.0551 0.0516
Onchocerca volvulus 0.0056 0.0948 0.0943
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0428 0.0393
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0121 0.2313 0.4798
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.2711 0.4465
Brugia malayi hypothetical protein 0.0016 0.0101 0.0044
Schistosoma mansoni ap endonuclease 0.0018 0.016 0.0129
Loa Loa (eye worm) hypothetical protein 0.0019 0.0168 0.0132
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0415 1
Mycobacterium tuberculosis Conserved protein 0.0037 0.0551 0.1022
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0429 0.0404
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0159 0.9916
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0074 0.0185
Loa Loa (eye worm) hypothetical protein 0.0014 0.0074 0.0037
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0095 0.0041
Trypanosoma brucei glucose transporter, putative 0.0032 0.0437 0.0614
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0437 0.0614
Brugia malayi glutathione reductase 0.0053 0.0887 0.0835
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0159 0.0097
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0415 0.0477
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0074 0.0185
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0429 0.0404
Schistosoma mansoni loxhd1 0.0021 0.021 0.0197
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0415 0.2006
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0521 0.0757
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0159 0.0144
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0016 0.0101 0.0328
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.016 0.0643
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0428 0.0495
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0095 0.0041
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0019 0.0168 0.0112
Loa Loa (eye worm) hypothetical protein 0.0019 0.0168 0.0132
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0016 0.0101 0.0328
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0907 0.1148
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0551 0.2731
Schistosoma mansoni glucose transport protein 0.0102 0.1912 0.2519
Onchocerca volvulus 0.0037 0.0551 0.0515
Loa Loa (eye worm) beta-lactamase 0.0037 0.0551 0.0516
Schistosoma mansoni hypothetical protein 0.0019 0.0168 0.014
Loa Loa (eye worm) hypothetical protein 0.0019 0.0168 0.0132
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0521 0.0757
Brugia malayi mbt repeat family protein 0.0047 0.0769 0.0717
Loa Loa (eye worm) hypothetical protein 0.0047 0.0769 0.0735
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0059 0.1012 0.1588
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0415 0.036
Onchocerca volvulus 0.0016 0.0101 0.0029
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0016 0.0101 0.0044
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0016 0.0101 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0437 0.2121
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.016 0.0184
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.1408 0.2258
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.2711 0.4465
Onchocerca volvulus 0.0019 0.0168 0.0101
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0251 1
Onchocerca volvulus 0.0019 0.0168 0.0101
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0159 0.9916
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0016 0.0101 0.0049
Echinococcus granulosus 5'partial|Low density lipoprotein receptor class A cysteine rich 0.0019 0.0168 0.014
Schistosoma mansoni hypothetical protein 0.0015 0.0095 0.0041
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0159 0.0144
Brugia malayi hypothetical protein 0.0021 0.021 0.0154
Loa Loa (eye worm) hypothetical protein 0.0015 0.0095 0.0059
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0907 0.1148
Trypanosoma brucei trypanothione reductase 0.0053 0.0887 0.1376
Schistosoma mansoni hypothetical protein 0.0019 0.0168 0.014
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0019 0.0168 0.014
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0016 0.0101 0.0049
Echinococcus granulosus basement membrane specific heparan sulfate 0.0019 0.0168 0.014
Entamoeba histolytica hypothetical protein 0.0023 0.0254 0.3295
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.1012 0.1292
Plasmodium vivax thioredoxin reductase, putative 0.0053 0.0887 0.0926
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0159 0.0097
Brugia malayi hypothetical protein 0.005 0.0828 0.0776
Brugia malayi CXXC zinc finger family protein 0.0056 0.0948 0.0896
Schistosoma mansoni ran 0.0021 0.021 0.0197
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0016 0.0101 0.0049
Brugia malayi major facilitator superfamily protein 0.0014 0.0074 0.0017
Echinococcus multilocularis cpg binding protein 0.0059 0.1015 0.1295
Loa Loa (eye worm) hypothetical protein 0.0019 0.0168 0.0132

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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