Detailed information for compound 553410

Basic information

Technical information
  • TDR Targets ID: 553410
  • Name: sodium 5-[3-[[2-[(4-amino-5-hydroxy-5-oxo-pen tanoyl)amino]-5-(3H-diazirin-3-yl)-5-oxo-pent anoyl]amino]diazirin-3-yl]-5-oxo-pentanoate
  • MW: 476.396 | Formula: C17H23N7NaO8
  • H donors: 4 H acceptors: 8 LogP: -3.7 Rotable bonds: 18
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC(C(=O)NC1(N=N1)C(=O)CCCC(=O)[O-])CCC(=O)C1N=N1)CCC(C(=O)O)N.[NaH+]
  • InChi: 1S/C17H23N7O8.Na/c18-8(16(31)32)4-7-12(27)19-9(5-6-10(25)14-21-22-14)15(30)20-17(23-24-17)11(26)2-1-3-13(28)29;/h8-9,14H,1-7,18H2,(H,19,27)(H,20,30)(H,28,29)(H,31,32);/q;+1/p-1
  • InChiKey: FPXRBCJGXOGIBY-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

  • sodium 5-[3-[[2-[(4-amino-5-hydroxy-1,5-dioxopentyl)amino]-5-(3H-diazirin-3-yl)-1,5-dioxopentyl]amino]-3-diazirinyl]-5-oxopentanoate
  • sodium 5-[3-[[2-[(4-azanyl-5-hydroxy-5-oxo-pentanoyl)amino]-5-(3H-1,2-diazirin-3-yl)-5-oxo-pentanoyl]amino]-1,2-diazirin-3-yl]-5-oxo-pentanoate
  • sodium 5-[3-[[2-[(4-amino-5-hydroxy-5-keto-pentanoyl)amino]-5-(3H-diazirin-3-yl)-5-keto-pentanoyl]amino]diazirin-3-yl]-5-keto-valerate
  • sodium 5-[3-[[2-[(4-amino-5-hydroxy-5-oxopentanoyl)amino]-5-(3H-diazirin-3-yl)-5-oxopentanoyl]amino]diazirin-3-yl]-5-oxopentanoate
  • sodium 5-[3-[[2-[(4-amino-5-hydroxy-5-oxo-pentanoyl)amino]-5-(3H-1,2-diazirin-3-yl)-5-oxo-pentanoyl]amino]-1,2-diazirin-3-yl]-5-oxo-pentanoate
  • 22204-48-4
  • AZOTOMYCIN MONOSODIUM

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Smad4 0.0016 0.0265 0.0979
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0362 1
Loa Loa (eye worm) Smad1 0.0016 0.0265 0.0267
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.0025 0.0661 0.2444
Schistosoma mansoni lamin 0.0053 0.1916 0.3196
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0362 0.0365
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0073 0.0073
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0233 0.0863
Loa Loa (eye worm) hypothetical protein 0.0017 0.0324 0.0327
Onchocerca volvulus 0.0036 0.1146 0.1146
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1575 0.2628
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.1146 0.0964
Schistosoma mansoni ap endonuclease 0.0018 0.0362 0.0603
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0073 0.0073
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1575 0.2628
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.2703 1
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.0025 0.0661 0.2444
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0821 0.0828
Trichomonas vaginalis esterase, putative 0.0036 0.1146 0.0911
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.4162 0.4151
Loa Loa (eye worm) hypothetical protein 0.0119 0.4787 0.4828
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0362 1
Loa Loa (eye worm) glutathione reductase 0.0046 0.1577 0.159
Onchocerca volvulus 0.0036 0.1146 0.1146
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.1146 0.424
Onchocerca volvulus 0.003 0.0875 0.0875
Plasmodium vivax hypothetical protein, conserved 0.0036 0.1146 0.6793
Plasmodium falciparum thioredoxin reductase 0.0046 0.1577 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0265 0.0979
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0233 0.0863
Schistosoma mansoni smad1 5 8 and 0.0016 0.0265 0.0442
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0583 0.3662
Loa Loa (eye worm) hypothetical protein 0.0017 0.0324 0.0327
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0875 0.1459
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0875 0.1459
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0258 0.0186
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.2703 0.4509
Mycobacterium leprae conserved hypothetical protein 0.0036 0.1146 0.1375
Trichomonas vaginalis succinate semialdehyde dehydrogenase, putative 0.0025 0.0661 0.0413
Loa Loa (eye worm) transcription factor SMAD2 0.0235 0.9916 1
Toxoplasma gondii thioredoxin reductase 0.0046 0.1577 1
Onchocerca volvulus 0.0053 0.1916 0.1916
Schistosoma mansoni aldehyde dehydrogenase 0.0025 0.0661 0.1102
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0258 0.0956
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.1146 0.1156
Loa Loa (eye worm) hypothetical protein 0.003 0.0875 0.0882
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0258 0.0186
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.1146 0.0964
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.2703 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0583 0.3662
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0258 0.0186
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0265 0.0979
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0362 0.0955
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0258 0.0026
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0583 0.037
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0258 0.0186
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0258 0.0186
Toxoplasma gondii exonuclease III APE 0.0018 0.0362 0.0955
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.1146 0.1156
Entamoeba histolytica hypothetical protein 0.0071 0.2703 1
Brugia malayi Pre-SET motif family protein 0.0208 0.8733 0.8806
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0283 0.0052
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0258 0.0186
Echinococcus granulosus lamin dm0 0.0053 0.1916 0.7087
Brugia malayi intermediate filament protein 0.0053 0.1916 0.1932
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.1916 0.1932
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.4676 0.4694
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.1146 0.0964
Loa Loa (eye worm) hypothetical protein 0.0023 0.0583 0.0588
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0258 0.0186
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.4676 0.4694
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0233 0.0863
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.4162 0.4151
Loa Loa (eye worm) hypothetical protein 0.0023 0.0583 0.0588
Echinococcus granulosus lamin 0.0053 0.1916 0.7087
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.1577 1
Brugia malayi Pre-SET motif family protein 0.003 0.0875 0.0882
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0233 0.0235
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.1577 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.6008 0.6058
Onchocerca volvulus Huntingtin homolog 0.0119 0.4787 0.4787
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0875 0.4775
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.4162 0.8745
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0233 0.0863
Loa Loa (eye worm) hypothetical protein 0.0026 0.0696 0.0702
Onchocerca volvulus 0.0036 0.1146 0.1146
Plasmodium falciparum glutathione reductase 0.0046 0.1577 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.1146 0.6793
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0258 0.0186
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0233 0.0863
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0583 0.2606
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.1575 0.1589
Onchocerca volvulus 0.0023 0.0583 0.0583
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0324 0.0678
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0696 0.2576
Mycobacterium tuberculosis Probable aldehyde dehydrogenase (NAD+) dependent 0.0025 0.0661 0.0452
Loa Loa (eye worm) hypothetical protein 0.0052 0.1872 0.1888
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0258 0.0186
Schistosoma mansoni Smad4 0.0016 0.0265 0.0442
Plasmodium vivax glutathione reductase, putative 0.0046 0.1577 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.1146 0.0911
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0583 0.0588
Loa Loa (eye worm) hypothetical protein 0.0017 0.0324 0.0327
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0258 0.0186
Brugia malayi beta-lactamase family protein 0.0036 0.1146 0.1156
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0362 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0583 0.0947
Loa Loa (eye worm) hypothetical protein 0.0119 0.4787 0.4828
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0258 0.0431
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0362 0.0955
Mycobacterium tuberculosis Conserved protein 0.0036 0.1146 0.0964
Mycobacterium ulcerans aldehyde dehydrogenase (NAD+) dependent 0.0025 0.0661 0.4533
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0583 0.037
Leishmania major trypanothione reductase 0.0046 0.1577 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.4162 0.4151
Loa Loa (eye worm) MH2 domain-containing protein 0.0235 0.9916 1
Onchocerca volvulus 0.0053 0.1916 0.1916
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0583 0.2606
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0583 0.3662
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0583 0.0947
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0362 0.0955
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0583 0.3662
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0233 0.0863
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0583 0.2606
Brugia malayi glutathione reductase 0.0046 0.1577 0.159
Brugia malayi beta-lactamase family protein 0.0036 0.1146 0.1156
Schistosoma mansoni smad 0.0016 0.0265 0.0442
Mycobacterium tuberculosis Conserved protein 0.0036 0.1146 0.0964
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.1146 0.6793
Brugia malayi hypothetical protein 0.0071 0.2703 0.2726
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0025 0.0661 0.3181
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0821 0.0828
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0265 0.0442
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0324 0.0096
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0362 0.0136
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.1575 0.5828
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0362 0.0106
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.1575 0.5828
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.1146 0.0964
Plasmodium falciparum thioredoxin reductase 0.0016 0.0258 0.0186
Brugia malayi Thioredoxin reductase 0.0046 0.1577 0.159
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0362 0.1338
Brugia malayi Smad1 0.0016 0.0265 0.0267
Brugia malayi MH1 domain containing protein 0.0016 0.0265 0.0267
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0258 0.0186
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0025 0.0661 0.3181
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0258 0.0186
Brugia malayi hypothetical protein 0.0146 0.6008 0.6058
Onchocerca volvulus Aldehyde dehydrogenase homolog 0.0025 0.0661 0.0661
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0258 0.026
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0875 0.1459
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.1577 0.142
Loa Loa (eye worm) intermediate filament protein 0.0053 0.1916 0.1932
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0258 0.0186
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.1146 1
Mycobacterium ulcerans hypothetical protein 0.0023 0.0583 0.3662
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0696 0.2576
Leishmania major hypothetical protein, conserved 0.0036 0.1146 0.6793
Trypanosoma brucei trypanothione reductase 0.0046 0.1577 1
Loa Loa (eye worm) beta-lactamase 0.0036 0.1146 0.1156
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0362 0.0955
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.1146 0.0911
Loa Loa (eye worm) hypothetical protein 0.0036 0.1146 0.1156
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0258 0.0186
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.1577 0.159
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0258 0.0186
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1575 0.2628
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.1146 0.424
Entamoeba histolytica aldehyde dehydrogenase 1, putative 0.0025 0.0661 0.1278
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0875 0.3237
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0258 0.0186
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.1916 0.1932
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.1146 0.6793
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0362 0.0955
Entamoeba histolytica hypothetical protein 0.0071 0.2703 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0583 0.0588
Echinococcus multilocularis lamin dm0 0.0053 0.1916 0.7087
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.1575 0.5828
Mycobacterium tuberculosis Conserved protein 0.0036 0.1146 0.0964
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0283 0.0052
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.1146 0.0911
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.1146 0.1912
Mycobacterium leprae Probable lipase LipE 0.0036 0.1146 0.1375
Brugia malayi beta-lactamase 0.0036 0.1146 0.1156
Brugia malayi hypothetical protein 0.0119 0.4787 0.4828
Entamoeba histolytica hypothetical protein 0.0071 0.2703 1
Brugia malayi MH2 domain containing protein 0.0016 0.0265 0.0267
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0258 0.0186
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0583 0.3662
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0258 0.0186
Mycobacterium ulcerans beta-lactamase 0.0036 0.1146 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0265 0.0267
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0362 0.1164
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0283 0.0052
Echinococcus multilocularis lamin 0.0053 0.1916 0.7087
Echinococcus granulosus smad 0.0016 0.0265 0.0979
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0826 0.3058
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.1146 0.0964
Loa Loa (eye worm) hypothetical protein 0.0025 0.0653 0.0659
Toxoplasma gondii ABC1 family protein 0.0036 0.1146 0.6793
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0233 0.0235
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.0025 0.0661 0.2444
Brugia malayi isocitrate dehydrogenase 0.0015 0.0233 0.0235
Echinococcus multilocularis ras gtp binding protein rho1 0.0022 0.0515 0.1905
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0324 0.0678
Schistosoma mansoni smad1 5 8 and 0.0016 0.0265 0.0442
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0583 0.0588
Loa Loa (eye worm) hypothetical protein 0.0036 0.1146 0.1156
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0258 0.0186
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.1146 0.0964
Mycobacterium ulcerans hypothetical protein 0.0036 0.1146 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.1146 0.1156
Onchocerca volvulus Huntingtin homolog 0.0119 0.4787 0.4787
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.1146 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.4162 0.4151
Brugia malayi MH2 domain containing protein 0.0235 0.9916 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0362 0.0955
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0258 0.0186
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0875 0.3237
Mycobacterium leprae PROBABLE ALDEHYDE DEHYDROGENASE (NAD+) DEPENDENT 0.0025 0.0661 0.0189
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.1577 0.5834
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0265 0.0979
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0025 0.0661 0.3181
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0283 0.0052
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0362 0.0365
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0583 0.3662
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0362 0.0106
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.1146 0.1912
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.4162 0.4151
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.1146 0.0964
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0362 0.1338
Brugia malayi Aldehyde dehydrogenase protein 4 0.0025 0.0661 0.0666
Plasmodium vivax SET domain protein, putative 0.003 0.0875 0.4775
Echinococcus granulosus intermediate filament protein 0.0053 0.1916 0.7087
Loa Loa (eye worm) hypothetical protein 0.0023 0.0583 0.0588
Loa Loa (eye worm) hypothetical protein 0.0036 0.1146 0.1156
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.1577 0.5834
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.1146 0.0911
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.8733 0.8806
Loa Loa (eye worm) hypothetical protein 0.0036 0.1146 0.1156
Echinococcus granulosus ras gtp binding protein rho1 0.0022 0.0515 0.1905
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.0025 0.0661 0.0666
Trichomonas vaginalis set domain proteins, putative 0.0237 1 1
Mycobacterium tuberculosis Probable reductase 0.0104 0.4162 0.4151
Loa Loa (eye worm) hypothetical protein 0.0053 0.1916 0.1932
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0258 0.0186
Brugia malayi MH1 domain containing protein 0.0016 0.0265 0.0267
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0875 0.1459
Brugia malayi MH2 domain containing protein 0.0016 0.0265 0.0267
Schistosoma mansoni hypothetical protein 0.0071 0.2703 0.4509
Schistosoma mansoni smad1 5 8 and 0.0016 0.0265 0.0442
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0233 0.0389
Loa Loa (eye worm) hypothetical protein 0.0036 0.1146 0.1156
Schistosoma mansoni ap endonuclease 0.0018 0.0362 0.0603
Schistosoma mansoni intermediate filament proteins 0.0053 0.1916 0.3196
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0875 0.3237
Loa Loa (eye worm) hypothetical protein 0.0017 0.0324 0.0327
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0583 0.3662
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0258 0.0186
Loa Loa (eye worm) hypothetical protein 0.0025 0.0653 0.0659
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0324 1
Echinococcus multilocularis smad 0.0016 0.0265 0.0979
Entamoeba histolytica hypothetical protein 0.0071 0.2703 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0265 0.0979
Mycobacterium tuberculosis Possible penicillin-binding protein 0.023 0.9698 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.1575 0.1589
Echinococcus multilocularis Smad4 0.0016 0.0265 0.0979
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0265 0.0267
Echinococcus multilocularis musashi 0.0053 0.1916 0.7087
Plasmodium falciparum glutathione reductase 0.0016 0.0258 0.0186
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.4676 0.4694
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.1146 0.0911
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.1575 0.5828
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.4676 1
Onchocerca volvulus 0.0146 0.6008 0.6008
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0258 0.0186
Loa Loa (eye worm) hypothetical protein 0.0017 0.0324 0.0327
Mycobacterium ulcerans lipase LipD 0.0036 0.1146 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0583 0.0947
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.0025 0.0661 0.2444
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0258 0.0956
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0324 0.0745
Schistosoma mansoni lamin 0.0053 0.1916 0.3196

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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