Detailed information for compound 555150

Basic information

Technical information
  • TDR Targets ID: 555150
  • Name: 2-[carboxymethyl(nitroso)amino]acetic acid
  • MW: 162.101 | Formula: C4H6N2O5
  • H donors: 2 H acceptors: 5 LogP: -0.62 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=NN(CC(=O)O)CC(=O)O
  • InChi: 1S/C4H6N2O5/c7-3(8)1-6(5-11)2-4(9)10/h1-2H2,(H,7,8)(H,9,10)
  • InChiKey: XLYVHYXTFHZCNY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[carboxymethyl(nitroso)amino]ethanoic acid
  • N-nitrosoiminodiacetic acid
  • 2-(carboxymethyl-nitrosoamino)acetic acid
  • 2-(carboxymethyl-nitroso-amino)acetic acid
  • 2-(carboxymethyl-nitroso-amino)ethanoic acid
  • 25081-31-6
  • CCRIS 2612
  • Glycine, N-(carboxymethyl)-N-nitroso- (9CI)
  • N-(Carboxymethyl)-N-nitrosoglycine
  • N-Nitrosoimidodiacetic acid
  • Nitrosoiminodiacetic acid
  • Glycine, N-(carboxymethyl)-N-nitroso-
  • 2,2'-(nitrosoimino)diacetic acid
  • 4-04-00-03396 (Beilstein Handbook Reference)
  • ACETIC ACID, NITROSIMINODI-
  • BRN 1708492

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0066 0.0193
Loa Loa (eye worm) hypothetical protein 0.0063 0.0475 0.1322
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0175 0.0588
Echinococcus granulosus snurportin 1 0.0303 0.3585 0.8714
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0944 0.263
Loa Loa (eye worm) hypothetical protein 0.0126 0.1291 0.36
Onchocerca volvulus 0.004 0.0175 1
Brugia malayi Reprolysin 0.0178 0.1963 0.5889
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0175 1
Schistosoma mansoni bromodomain containing protein 0.0127 0.1309 0.3149
Echinococcus multilocularis geminin 0.0344 0.411 0.4094
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0944 0.2829
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0153 0.3227
Schistosoma mansoni hypothetical protein 0.0068 0.0537 0.1263
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0175 0.0362
Brugia malayi Disintegrin family protein 0.0134 0.1389 0.4166
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0104 0.0203
Trypanosoma brucei unspecified product 0.0038 0.0153 0.3227
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0175 0.0377
Schistosoma mansoni hypothetical protein 0.0344 0.411 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0303 0.3585 1
Loa Loa (eye worm) disintegrin family protein 0.0067 0.0523 0.1457
Schistosoma mansoni hypothetical protein 0.0344 0.411 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0104 0.0077
Leishmania major DNA polymerase eta, putative 0.0037 0.0134 0.2811
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0284 0.3333 0.8099
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0175 0.0377
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.0153 0.0515
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0284 0.3333 0.3315
Onchocerca volvulus 0.004 0.0175 1
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0175 0.2803
Plasmodium falciparum importin beta, putative 0.0028 0.0027 0.5
Schistosoma mansoni hypothetical protein 0.0031 0.0066 0.0109
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0153 0.3227
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0153 0.3227
Brugia malayi angiogenesis inhibito 0.0078 0.0665 0.1992
Echinococcus granulosus adam 0.0176 0.1935 0.4674
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0066 0.0193
Mycobacterium leprae conserved hypothetical protein 0.004 0.0175 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0104 0.0203
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0175 0.0485
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0066 0.0095
Brugia malayi metalloprotease 0.0028 0.0021 0.0059
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0038 0.0153 0.0424
Loa Loa (eye worm) hypothetical protein 0.0078 0.0665 0.1852
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0175 1
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0245 0.2829 0.6867
Schistosoma mansoni terminal deoxycytidyl transferase 0.0038 0.0153 0.0323
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0175 1
Loa Loa (eye worm) bromodomain containing protein 0.0036 0.012 0.0331
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0254 0.2953 1
Brugia malayi Importin beta-1 subunit 0.0028 0.0027 0.0077
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0153 0.3227
Echinococcus multilocularis adam 0.0176 0.1935 0.1913
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0284 0.3333 0.8096
Trypanosoma cruzi DNA polymerase eta, putative 0.0063 0.0475 1
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0245 0.2829 0.6862
Loa Loa (eye worm) hypothetical protein 0.0082 0.0721 0.2009
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0153 0.3227
Loa Loa (eye worm) reprolysin 0.0245 0.2829 0.7891
Loa Loa (eye worm) hypothetical protein 0.0086 0.0771 0.2148
Loa Loa (eye worm) hypothetical protein 0.0034 0.0104 0.0286
Schistosoma mansoni DNA polymerase eta 0.0063 0.0475 0.111
Trypanosoma brucei DNA polymerase eta, putative 0.0063 0.0475 1
Loa Loa (eye worm) hypothetical protein 0.0103 0.0992 0.2765
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0944 0.2829
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0245 0.2829 0.2809
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0245 0.2829 0.6867
Leishmania major DNA polymerase kappa, putative 0.0038 0.0153 0.3208
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0537 0.1609
Echinococcus granulosus geminin 0.0344 0.411 1
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0153 0.3227
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0153 0.3227
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0066 0.0095
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0153 0.3227
Schistosoma mansoni zinc finger protein 0.0039 0.017 0.0363
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0038 0.0153 0.0127
Schistosoma mansoni hypothetical protein 0.0303 0.3585 0.8715
Brugia malayi ImpB/MucB/SamB family protein 0.0063 0.0475 0.1422
Echinococcus granulosus adam 17 protease 0.0067 0.0525 0.122
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0596 0.057
Brugia malayi beta-lactamase family protein 0.004 0.0175 0.0521
Echinococcus granulosus dna polymerase eta 0.0063 0.0475 0.1097
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0153 0.8751
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0027 0.057
Loa Loa (eye worm) PHD-finger family protein 0.0042 0.0197 0.0547
Echinococcus multilocularis dna polymerase eta 0.0063 0.0475 0.0449
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0038 0.0153 0.0309
Mycobacterium ulcerans beta-lactamase 0.004 0.0175 1
Echinococcus multilocularis disintegrin and metalloproteinase 0.0134 0.1389 0.1366
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0175 0.3683
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0175 0.0521
Loa Loa (eye worm) hypothetical protein 0.0142 0.1503 0.4189
Mycobacterium ulcerans lipase LipD 0.004 0.0175 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0104 0.0188
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0175 0.0148
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0175 1
Leishmania major hypothetical protein, conserved 0.004 0.0175 0.3666
Loa Loa (eye worm) metalloprotease 0.0028 0.0021 0.0055
Schistosoma mansoni hypothetical protein 0.0031 0.0066 0.0109
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0045 0.0247 0.0552
Loa Loa (eye worm) hypothetical protein 0.0099 0.0944 0.263
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0034 0.0104 0.0077
Entamoeba histolytica deoxycytidyl transferase, putative 0.0038 0.0153 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.012 0.1215 0.291
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0485
Schistosoma mansoni hypothetical protein 0.0031 0.0066 0.0109
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0153 0.3227
Mycobacterium tuberculosis Conserved protein 0.004 0.0175 0.0588
Schistosoma mansoni hypothetical protein 0.0042 0.0197 0.0431
Leishmania major DNA polymerase eta, putative 0.0063 0.0475 1
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0153 0.8751
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0038 0.0153 0.3208
Echinococcus granulosus methyl CpG binding domain protein 2 0.0034 0.0104 0.0188
Brugia malayi PHD-finger family protein 0.005 0.0309 0.0923
Loa Loa (eye worm) hypothetical protein 0.0077 0.0659 0.1837
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0153 0.2283
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0175 0.0588
Schistosoma mansoni hypothetical protein 0.0031 0.0066 0.0109
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0104 0.0203
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0072
Brugia malayi Bromodomain containing protein 0.0151 0.1614 0.4841
Giardia lamblia DINP protein human, muc B family 0.0038 0.0153 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0284 0.3333 0.9297
Toxoplasma gondii ABC1 family protein 0.004 0.0175 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0665 0.1852
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0153 0.2283
Echinococcus granulosus GPCR family 2 0.0031 0.0066 0.0095
Brugia malayi ADAMTS-like protease 0.0078 0.0665 0.1992
Loa Loa (eye worm) angiogenesis inhibito 0.0028 0.0021 0.0055
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0175 0.0588
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0284 0.3333 0.8099
Echinococcus multilocularis snurportin 1 0.0303 0.3585 0.3567
Mycobacterium tuberculosis Conserved protein 0.004 0.0175 0.0588
Schistosoma mansoni importin beta-1 0.0028 0.0027 0.0015
Brugia malayi RNA, U transporter 1 0.0081 0.0705 0.2112
Brugia malayi Bromodomain containing protein 0.0077 0.0658 0.197
Loa Loa (eye worm) hypothetical protein 0.005 0.0303 0.0843
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0175 1
Echinococcus granulosus disintegrin and metalloproteinase 0.0134 0.1389 0.3336
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0153 0.3227
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0175 0.0588
Echinococcus granulosus dna polymerase kappa 0.0038 0.0153 0.0309
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0038 0.0153 0.0323
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0066 0.0039
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0045 0.0247 0.022
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0103 0.0992 0.2364
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0485
Mycobacterium tuberculosis Conserved protein 0.004 0.0175 0.0588
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0153 0.3227
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0037 0.0134 0.7261
Onchocerca volvulus 0.004 0.0175 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0175 0.0588
Echinococcus multilocularis dna polymerase kappa 0.0038 0.0153 0.0127
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0284 0.3333 1
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0153 0.3227
Mycobacterium leprae Probable lipase LipE 0.004 0.0175 1
Plasmodium vivax hypothetical protein, conserved 0.004 0.0175 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0027 0.057
Schistosoma mansoni hypothetical protein 0.0031 0.0058 0.0091
Brugia malayi ADAM-TS Spacer 1 family protein 0.0078 0.0665 0.1992
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0175 1
Brugia malayi hypothetical protein 0.0176 0.1935 0.5805
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0485
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0153 0.0456
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.0134 0.1831
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0038 0.0153 0.0515
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0175 0.0588
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0153 0.2283
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.012 0.1215 0.1191
Mycobacterium ulcerans hypothetical protein 0.004 0.0175 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0175 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0485
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0104 0.0203
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0175 0.2803
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0103 0.0992 0.0968
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0066 0.0039
Leishmania major hypothetical protein, conserved 0.0031 0.0058 0.1199
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0284 0.3333 0.3315
Echinococcus multilocularis zinc finger protein 0.0039 0.017 0.0143
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0176 0.1935 0.4682
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0284 0.3333 0.8099
Trichomonas vaginalis esterase, putative 0.004 0.0175 1
Echinococcus granulosus zinc finger protein 0.0039 0.017 0.0349
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0175 0.0588
Schistosoma mansoni dihydroceramide desaturase 0.0134 0.1389 0.3346
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0485
Loa Loa (eye worm) hypothetical protein 0.0068 0.0537 0.1496
Loa Loa (eye worm) hypothetical protein 0.0028 0.0021 0.0055
Loa Loa (eye worm) beta-lactamase 0.004 0.0175 0.0485
Trypanosoma brucei ISWI complex protein 0.0031 0.0058 0.1223
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0284 0.3333 0.8096
Brugia malayi beta-lactamase 0.004 0.0175 0.0521
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0485
Echinococcus multilocularis GPCR, family 2 0.0031 0.0066 0.0039
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0153 0.2283
Brugia malayi beta-lactamase family protein 0.004 0.0175 0.0521
Loa Loa (eye worm) hypothetical protein 0.0031 0.0066 0.018
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0153 0.3227
Schistosoma mansoni zinc finger protein 0.0031 0.0058 0.0091
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0066 0.018
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0596 0.1393
Echinococcus granulosus fetal alzheimer antigen falz 0.0045 0.0247 0.0538

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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