Detailed information for compound 563972

Basic information

Technical information
  • TDR Targets ID: 563972
  • Name: 2-hydroxy-4-[(2-iodoacetyl)amino]benzoic acid
  • MW: 321.069 | Formula: C9H8INO4
  • H donors: 3 H acceptors: 4 LogP: 1.5 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: ICC(=O)Nc1ccc(c(c1)O)C(=O)O
  • InChi: 1S/C9H8INO4/c10-4-8(13)11-5-1-2-6(9(14)15)7(12)3-5/h1-3,12H,4H2,(H,11,13)(H,14,15)
  • InChiKey: QEQAPQHGLVGWMO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-hydroxy-4-[(2-iodo-1-oxoethyl)amino]benzoic acid
  • 2-hydroxy-4-(2-iodoethanoylamino)benzoic acid
  • 4-iodoacetamidosalicylic acid
  • 4323-00-6
  • 2-Hydroxy-4-((iodoacetyl)amino)benzoic acid
  • 4-14-00-02021 (Beilstein Handbook Reference)
  • BRN 2654510
  • Benzoic acid, 2-hydroxy-4-((iodoacetyl)amino)- (9CI)
  • NSC 55320
  • NCIOpen2_007449
  • 4-(Iodoacetamido)salicylic acid
  • 4-Iodoacetamidosalicyclic acid
  • Ba 2785
  • Benzoic acid, 2-hydroxy-4-[(iodoacetyl)amino]-
  • IAS
  • NSC55320
  • Salicylic acid, 4-(2-iodoacetamido)-
  • WLN: QVR BQ DMV1I

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0571 0.2084
Toxoplasma gondii hypothetical protein 0.0032 0.0325 0.0672
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0049 0.0571 1
Trypanosoma brucei polo-like protein kinase 0.0092 0.1195 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0037 0.0389 0.5
Brugia malayi Fibulin-1 precursor 0.0013 0.0042 0.0152
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0013 0.0042 0.0152
Schistosoma mansoni hypothetical protein 0.0015 0.0076 0.0076
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.1195 0.6885
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0173 0.0173
Onchocerca volvulus 0.0032 0.0325 0.1873
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0516 0.4007
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0389 0.6266
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0014 0.0063 0.0301
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1195 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0037 0.0389 0.142
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.1195 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0571 1
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.1195 0.1195
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0017 0.0099 0.0362
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0063 0.0301
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0013 0.0047 0.0047
Schistosoma mansoni troponin I 0.0104 0.137 0.137
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0047 0.0047
Echinococcus multilocularis zinc finger protein 0.0019 0.0131 0.0131
Onchocerca volvulus 0.0014 0.0063 0.0362
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0095 0.0095
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0063 0.0229
Brugia malayi PAN domain containing protein 0.0032 0.0325 0.1186
Loa Loa (eye worm) hypothetical protein 0.0037 0.0389 0.142
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0014 0.0063 0.0301
Onchocerca volvulus 0.0013 0.0047 0.027
Leishmania major phospholipase c-like protein 0.0021 0.0161 0.0868
Brugia malayi Trypsin-like protease protein 5 0.0013 0.0047 0.0171
Loa Loa (eye worm) hypothetical protein 0.0049 0.0571 0.2084
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0063 0.0063
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0571 0.4493
Toxoplasma gondii PAN domain-containing protein 0.0302 0.426 1
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0013 0.0042 0.0152
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0049 0.0571 1
Onchocerca volvulus 0.0018 0.0114 0.0658
Brugia malayi Troponin T 0.0062 0.0752 0.2744
Loa Loa (eye worm) TK/ROR protein kinase 0.005 0.0584 0.213
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0014 0.0063 0.0301
Brugia malayi Troponin T 0.0062 0.0752 0.2744
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0014 0.0063 0.0301
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0049 0.0571 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0033 0.0336 0.1226
Onchocerca volvulus 0.0032 0.0325 0.1873
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0063 0.0301
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0063 0.0301
Loa Loa (eye worm) hypothetical protein 0.0014 0.0063 0.0229
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.0584 0.4604
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0063 0.0229
Loa Loa (eye worm) hypothetical protein 0.0013 0.0047 0.0171
Echinococcus multilocularis enteropeptidase 0.0013 0.0047 0.0047
Toxoplasma gondii PAN/Apple domain-containing protein 0.0032 0.0325 0.0672
Loa Loa (eye worm) hypothetical protein 0.0013 0.0042 0.0152
Brugia malayi Trypsin family protein 0.0013 0.0047 0.0171
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0013 0.0047 0.0047
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.056 0.2044
Onchocerca volvulus 0.0049 0.0571 0.3292
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0063 0.0301
Loa Loa (eye worm) hypothetical protein 0.005 0.0584 0.213
Loa Loa (eye worm) hypothetical protein 0.0042 0.046 0.1678
Brugia malayi Bromodomain containing protein 0.0037 0.0398 0.1451
Leishmania major phosphatidylinositol-specific phospholipase-like protein 0.0017 0.0099 0.0323
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0013 0.0047 0.0171
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1195 1
Brugia malayi Protein kinase domain containing protein 0.005 0.0584 0.213
Echinococcus multilocularis glycoprotein Antigen 5 0.0013 0.0047 0.0047
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0063 0.0546
Trypanosoma brucei ISWI complex protein 0.0015 0.007 0.0061
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0047 0.0047
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.0047 0.0047
Onchocerca volvulus Troponin I homolog 0.0104 0.137 0.7895
Loa Loa (eye worm) hypothetical protein 0.0032 0.0325 0.1186
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.056 0.2044
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0095 0.0095
Loa Loa (eye worm) trypsin family protein 0.0013 0.0047 0.0171
Mycobacterium ulcerans hypothetical protein 0.0049 0.0571 1
Echinococcus granulosus Mastin 0.0013 0.0047 0.0047
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0516 0.4007
Brugia malayi Troponin I 0.0104 0.137 0.4998
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.1195 0.4358
Toxoplasma gondii subtilisin SUB12 0.0032 0.0325 0.0672
Loa Loa (eye worm) hypothetical protein 0.0032 0.0325 0.1186
Loa Loa (eye worm) hypothetical protein 0.0013 0.0047 0.0171
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0389 0.6617
Loa Loa (eye worm) troponin T 0.0062 0.0752 0.2744
Loa Loa (eye worm) hypothetical protein 0.0032 0.0325 0.1186
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0198 0.2741 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0325 0.1186
Loa Loa (eye worm) hypothetical protein 0.0018 0.0114 0.0417
Schistosoma mansoni hypothetical protein 0.0015 0.0076 0.0076
Onchocerca volvulus 0.0032 0.0325 0.1873
Brugia malayi PAN domain containing protein 0.0032 0.0325 0.1186
Echinococcus multilocularis troponin i 0.0104 0.137 0.137
Onchocerca volvulus 0.0013 0.0047 0.027
Loa Loa (eye worm) PAN domain-containing protein 0.0032 0.0325 0.1186
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0165 0.2256 0.2256
Schistosoma mansoni egf-like domain protein 0.0013 0.0042 0.0042
Schistosoma mansoni kinase 0.0047 0.0534 0.0534
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0063 0.0229
Trypanosoma brucei phosphoinositide-specific phospholipase C 0.0018 0.0114 0.0455
Leishmania major hypothetical protein, conserved 0.005 0.0584 0.4604
Echinococcus granulosus Tolloid protein 1 0.0013 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0049 0.0571 0.2084
Loa Loa (eye worm) hypothetical protein 0.0017 0.0099 0.0362
Loa Loa (eye worm) hypothetical protein 0.0018 0.0114 0.0417
Onchocerca volvulus 0.0013 0.0047 0.027
Toxoplasma gondii microneme protein, putative 0.0032 0.0325 0.0672
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0013 0.0042 0.0152
Echinococcus granulosus GPCR family 2 0.0015 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0013 0.0042 0.0152
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0013 0.0047 0.0047
Plasmodium falciparum phosphoinositide-specific phospholipase C 0.0017 0.0099 0.0701
Loa Loa (eye worm) hypothetical protein 0.0037 0.0389 0.142
Leishmania major phosphoinositide-specific phospholipase C, putative 0.0017 0.0099 0.0323
Echinococcus multilocularis fibrillin 1 0.0013 0.0042 0.0042
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0076 0.0076
Onchocerca volvulus 0.0013 0.0047 0.027
Echinococcus multilocularis laminin 0.0013 0.0042 0.0042
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.0047 0.0047
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.0047 0.0047
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0032 0.0325 0.0672
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0014 0.0063 0.0301
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.0047 0.0047
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0571 1
Brugia malayi PAN domain containing protein 0.0032 0.0325 0.1186
Schistosoma mansoni hypothetical protein 0.005 0.0584 0.0584
Onchocerca volvulus Arrow homolog 0.0013 0.0042 0.0241
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0063 0.0229
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0129 0.1735 1
Onchocerca volvulus 0.0032 0.0325 0.1873
Loa Loa (eye worm) hypothetical protein 0.0032 0.0325 0.1186
Onchocerca volvulus 0.0014 0.0063 0.0362
Echinococcus granulosus enteropeptidase 0.0013 0.0047 0.0047
Echinococcus multilocularis microtubule associated protein 2 0.0694 1 1
Toxoplasma gondii microneme protein MIC17C 0.0032 0.0325 0.0672
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0062 0.0752 0.4335
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0063 0.0546
Toxoplasma gondii kringle domain-containing protein 0.005 0.0584 0.1285
Brugia malayi PAN domain containing protein 0.0032 0.0325 0.1186
Echinococcus granulosus glycoprotein Antigen 5 0.0013 0.0047 0.0047
Trypanosoma cruzi ISWI complex protein 0.0015 0.007 0.0061
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0063 0.0229
Schistosoma mansoni hypothetical protein 0.0104 0.137 0.137
Loa Loa (eye worm) hypothetical protein 0.0013 0.0047 0.0171
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0571 0.2084
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0173 0.0173
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.0047 0.0047
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0571 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.0047 0.0047
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0049 0.0571 1
Loa Loa (eye worm) PAN domain-containing protein 0.0032 0.0325 0.1186
Loa Loa (eye worm) troponin 0.0062 0.0752 0.2744
Brugia malayi Variant SH3 domain containing protein 0.0124 0.1663 0.6068
Toxoplasma gondii hypothetical protein 0.0032 0.0325 0.0672
Toxoplasma gondii microneme protein MIC17B 0.0032 0.0325 0.0672
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0047 0.0047
Brugia malayi Bromodomain containing protein 0.0073 0.0921 0.3362
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1195 1
Toxoplasma gondii microneme protein MIC4 0.0032 0.0325 0.0672
Loa Loa (eye worm) hypothetical protein 0.0013 0.0047 0.0171
Toxoplasma gondii phosphoinositide phospholipase PIPLC 0.0018 0.0114 0.0172
Schistosoma mansoni hypothetical protein 0.0015 0.007 0.007
Loa Loa (eye worm) troponin I 0.0104 0.137 0.4998
Schistosoma mansoni hypothetical protein 0.0013 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0014 0.0063 0.0229
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0063 0.0546
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0571 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.1195 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0095 0.0095
Schistosoma mansoni phospholipase C-like protein 2 plc-L2 0.0011 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0033 0.0336 0.0336
Toxoplasma gondii PAN domain-containing protein 0.0032 0.0325 0.0672
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.0047 0.0047
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.036 0.6071
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0173 0.0173
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0063 0.0301
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0124 0.1663 0.6068
Echinococcus multilocularis Mastin 0.0013 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0013 0.0047 0.0171
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0013 0.0042 0.0042
Schistosoma mansoni zinc finger protein 0.0015 0.007 0.007
Echinococcus multilocularis oncosphere protein tso22e oncosphere protein tso22d oncosphere protein tso22c oncosphere protein tso22b oncosphere protein tso22 0.0129 0.1735 0.1735
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0013 0.0047 0.0047
Onchocerca volvulus 0.0014 0.0063 0.0362
Onchocerca volvulus 0.0032 0.0325 0.1873
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0047 0.0047
Echinococcus granulosus troponin i 0.0104 0.137 0.137
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0047 0.0047
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0076 0.0276
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0018 0.0114 0.0417
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0063 0.0546
Brugia malayi Calcium binding EGF domain containing protein 0.0013 0.0042 0.0152
Schistosoma mansoni phospholipase C beta 0.0017 0.0099 0.0099
Loa Loa (eye worm) oxidoreductase 0.0014 0.0063 0.0229
Loa Loa (eye worm) hypothetical protein 0.0037 0.0389 0.142
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0076 0.0276
Brugia malayi PAN domain containing protein 0.0032 0.0325 0.1186
Schistosoma mansoni hypothetical protein 0.002 0.0146 0.0146
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0049 0.0571 1
Schistosoma mansoni troponin I 0.0104 0.137 0.137
Schistosoma mansoni zinc finger protein 0.0019 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0049 0.0571 0.2084
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0063 0.0063
Onchocerca volvulus 0.0032 0.0325 0.1873
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.036 0.6071
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0063 0.0301
Brugia malayi hypothetical protein 0.0062 0.0752 0.2744
Onchocerca volvulus 0.0014 0.0063 0.0362
Loa Loa (eye worm) hypothetical protein 0.0062 0.0752 0.2744
Onchocerca volvulus 0.0032 0.0325 0.1873
Loa Loa (eye worm) hypothetical protein 0.0104 0.137 0.4998
Echinococcus multilocularis tissue type plasminogen activator 0.005 0.0584 0.0584
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.1195 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0042 0.0152
Brugia malayi Troponin T 0.0062 0.0752 0.2744
Echinococcus multilocularis GPCR, family 2 0.0015 0.0076 0.0076
Schistosoma mansoni troponin I 0.0104 0.137 0.137
Brugia malayi PAN domain containing protein 0.0032 0.0325 0.1186
Brugia malayi PAN domain containing protein 0.0032 0.0325 0.1186
Brugia malayi Trypsin family protein 0.0013 0.0047 0.0171
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0364 0.0364
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0014 0.0063 0.0301
Brugia malayi 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 0.0017 0.0099 0.0362
Schistosoma mansoni microtubule-associated protein tau 0.0694 1 1
Onchocerca volvulus 0.0013 0.0047 0.027
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0063 0.0546
Mycobacterium ulcerans acetyl-CoA synthetase 0.0014 0.0063 0.0301
Toxoplasma gondii PAN domain-containing protein 0.0302 0.426 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0047 0.0047
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0063 0.005
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0336 0.1226
Schistosoma mansoni bromodomain containing protein 0.0062 0.0754 0.0754
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0165 0.2256 0.2256
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0063 0.0063
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0014 0.0063 0.0301
Onchocerca volvulus 0.0032 0.0325 0.1873
Toxoplasma gondii microneme protein MIC17A 0.0032 0.0325 0.0672
Plasmodium vivax phospholipase C-like, putative 0.0017 0.0099 0.0701
Onchocerca volvulus 0.0013 0.0047 0.027
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1195 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0063 0.0546
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0047 0.0047
Plasmodium vivax cysteine repeat modular protein 1, putative 0.005 0.0584 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0095 0.0095
Loa Loa (eye worm) PAN domain-containing protein 0.0032 0.0325 0.1186
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0571 1
Loa Loa (eye worm) Plcb4 protein 0.0017 0.0099 0.0362
Echinococcus multilocularis Tolloid protein 1 0.0013 0.0042 0.0042
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0703 0.0703
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0063 0.0546
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1195 1
Brugia malayi PAN domain containing protein 0.0032 0.0325 0.1186
Loa Loa (eye worm) PAN domain-containing protein 0.0032 0.0325 0.1186
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0571 0.4493
Brugia malayi PHD-finger family protein 0.0024 0.0207 0.0755
Brugia malayi PAN domain containing protein 0.0032 0.0325 0.1186
Loa Loa (eye worm) hypothetical protein 0.0198 0.2741 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0325 0.1186
Brugia malayi PAN domain containing protein 0.0032 0.0325 0.1186
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0047 0.0047
Brugia malayi Troponin family protein 0.0104 0.137 0.4998
Loa Loa (eye worm) hypothetical protein 0.0069 0.086 0.3139
Onchocerca volvulus 0.0032 0.0325 0.1873
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0063 0.0301
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0364 0.0364
Toxoplasma gondii propionate-CoA ligase 0.0014 0.0063 0.005
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0063 0.0546
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1195 1
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0013 0.0047 0.0047
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0146 0.0532
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0276
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.1195 1
Onchocerca volvulus 0.0018 0.0114 0.0658
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0013 0.0042 0.0152
Loa Loa (eye worm) hypothetical protein 0.0104 0.137 0.4998
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.0018 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0013 0.0047 0.0171
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0571 0.2084
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0703 0.0703
Schistosoma mansoni hypothetical protein 0.0013 0.0047 0.0047
Giardia lamblia Kinase, PLK 0.0092 0.1195 0.5
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0571 0.4493
Loa Loa (eye worm) PAN domain-containing protein 0.0032 0.0325 0.1186
Loa Loa (eye worm) hypothetical protein 0.0013 0.0047 0.0171
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.004 0.0433 0.1578
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0571 0.4493
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.036 0.6071
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0063 0.0229
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.036 0.6071
Schistosoma mansoni hypothetical protein 0.0015 0.0076 0.0076
Brugia malayi Trypsin family protein 0.0013 0.0047 0.0171
Schistosoma mansoni hypothetical protein 0.0015 0.0076 0.0076
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0063 0.0546
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0047 0.0047
Onchocerca volvulus 0.0032 0.0325 0.1873
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0063 0.0229
Loa Loa (eye worm) hypothetical protein 0.0013 0.0042 0.0152
Toxoplasma gondii PAN domain-containing protein 0.0032 0.0325 0.0672
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0063 0.0301
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0389 0.6266
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0076 0.0276
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0047 0.0047
Echinococcus granulosus tissue type plasminogen activator 0.005 0.0584 0.0584
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0571 1
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0063 0.0546
Plasmodium falciparum cysteine repeat modular protein 1 0.005 0.0584 1
Schistosoma mansoni troponin t invertebrate 0.0129 0.1735 0.1735
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0014 0.0063 0.0301
Echinococcus granulosus laminin 0.0013 0.0042 0.0042
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0095 0.0095
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0063 0.0229
Loa Loa (eye worm) hypothetical protein 0.0037 0.0399 0.1455
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0095 0.0095
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.0063 0.005
Loa Loa (eye worm) hypothetical protein 0.0037 0.0389 0.142
Loa Loa (eye worm) hypothetical protein 0.0032 0.0325 0.1186
Toxoplasma gondii PAN domain-containing protein 0.0032 0.0325 0.0672
Echinococcus multilocularis transmembrane protease serine 3 0.0013 0.0047 0.0047
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0018 0.0114 0.0417
Brugia malayi Trypsin family protein 0.0013 0.0047 0.0171
Schistosoma mansoni troponin I 0.0104 0.137 0.137
Onchocerca volvulus 0.0032 0.0325 0.1873
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0103 0.0377
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0063 0.0546
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1195 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.1195 0.1195
Echinococcus granulosus zinc finger protein 0.0019 0.0131 0.0131
Entamoeba histolytica acyl-coA synthetase, putative 0.0049 0.0571 0.4493
Brugia malayi phospholipase C homolog 0.0011 0.001 0.0036
Leishmania major hypothetical protein, conserved 0.0015 0.007 0.0061
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.1195 0.4358
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0345
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.1195 0.1195
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0095 0.0095
Trypanosoma cruzi ISWI complex protein 0.0015 0.007 0.0061
Loa Loa (eye worm) hypothetical protein 0.0013 0.0042 0.0152
Echinococcus granulosus oncosphere protein Tso22e 0.0129 0.1735 0.1735
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.0018 0.0114 0.0114
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0571 0.4493
Echinococcus granulosus transmembrane protease serine 3 0.0013 0.0047 0.0047
Brugia malayi hypothetical protein 0.0013 0.0047 0.0171
Onchocerca volvulus 0.005 0.0584 0.3365
Brugia malayi Kringle domain containing protein 0.005 0.0584 0.213
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.0389 0.6529
Toxoplasma gondii PAN domain-containing protein 0.0032 0.0325 0.0672
Trypanosoma cruzi phosphoinositide-specific phospholipase C, putative 0.0018 0.0114 0.0455

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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