Detailed information for compound 569727

Basic information

Technical information
  • TDR Targets ID: 569727
  • Name: 8-chloro-9,10-dihydrobenzo[b][1]benzothiepine -5-carboxylic acid
  • MW: 290.765 | Formula: C15H11ClO2S
  • H donors: 1 H acceptors: 2 LogP: 3.59 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: ClC1=CC2=C(CC1)Sc1c(C(=C2)C(=O)O)cccc1
  • InChi: 1S/C15H11ClO2S/c16-10-5-6-13-9(7-10)8-12(15(17)18)11-3-1-2-4-14(11)19-13/h1-4,7-8H,5-6H2,(H,17,18)
  • InChiKey: UDULSEXXHDFOIO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 87033-45-2
  • 10,11-Dihydro-2-chlorodibenzo(b,f)thiepin-10-carboxylic acid
  • 2-Chloro-10,11-dihydrodibenzo(b,f)thiepin-10-carboxylic acid
  • BRN 4479106
  • DIBENZO(b,f)THIEPIN-10-CARBOXYLIC ACID, 10,11-DIHYDRO-2-CHLORO-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0115 0.1446 0.3381
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0273 0.1668
Brugia malayi Fli-1 protein 0.0215 0.2812 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0157 0.2025 0.7203
Trypanosoma cruzi ISWI complex protein 0.0016 0.0085 0.0334
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.034 0.0794
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0412 0.4275
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0674 0.452
Echinococcus multilocularis GPCR, family 2 0.0047 0.0512 0.1198
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0195 0.1112
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0784 0.1833
Schistosoma mansoni aldehyde dehydrogenase 0.0131 0.1664 0.3891
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0412 0.0963
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.0412 0.4865
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0077 0.0913 0.2135
Mycobacterium ulcerans aldehyde dehydrogenase 0.0131 0.1664 1
Trypanosoma brucei hypothetical protein, conserved 0.0115 0.1446 1
Brugia malayi RNA binding protein 0.0203 0.2652 0.9433
Brugia malayi PHD-finger family protein 0.0029 0.0252 0.0896
Loa Loa (eye worm) hypothetical protein 0.015 0.1924 0.4497
Schistosoma mansoni ferritin light chain 0.0019 0.012 0.028
Schistosoma mansoni importin beta-1 0.003 0.0273 0.0638
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.034 0.1855
Loa Loa (eye worm) hypothetical protein 0.0048 0.0514 0.1201
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.045 0.2926
Echinococcus granulosus GA binding protein alpha chain 0.0071 0.0832 0.1944
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.039 0.0911
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.034 0.2142
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0038 0.0135
Schistosoma mansoni tar DNA-binding protein 0.0203 0.2652 0.62
Schistosoma mansoni tar DNA-binding protein 0.0203 0.2652 0.62
Schistosoma mansoni zinc finger protein 0.0016 0.0085 0.0199
Loa Loa (eye worm) hypothetical protein 0.0142 0.182 0.4254
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.039 0.0911
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0195 0.1112
Leishmania major hypothetical protein, conserved 0.0016 0.0085 0.0289
Schistosoma mansoni gabp alpha 0.0071 0.0832 0.1944
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.034 0.2142
Trypanosoma brucei ISWI complex protein 0.0016 0.0085 0.0334
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0196 0.2557 0.5978
Schistosoma mansoni hypothetical protein 0.0321 0.4277 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0412 0.2657
Brugia malayi hypothetical protein 0.0077 0.0913 0.3247
Schistosoma mansoni tar DNA-binding protein 0.0203 0.2652 0.62
Loa Loa (eye worm) beta-lactamase 0.0115 0.1446 0.3381
Schistosoma mansoni transcription factor LCR-F1 0.0077 0.0913 0.2135
Onchocerca volvulus 0.0115 0.1446 0.7904
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0236 0.6628
Schistosoma mansoni ferritin light chain 0.0019 0.012 0.028
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0164 0.0382
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0412 0.0963
Mycobacterium tuberculosis Conserved protein 0.0115 0.1446 0.1342
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0196 0.2557 0.5978
Mycobacterium tuberculosis Probable lipase LipE 0.0115 0.1446 0.1342
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0412 0.0963
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.034 0.2142
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0512 0.1822
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0412 0.2657
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0512 0.1198
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.034 0.2142
Loa Loa (eye worm) transcription factor SMAD2 0.0115 0.1446 0.3381
Trypanosoma brucei protein kinase, putative 0.0059 0.0674 0.452
Loa Loa (eye worm) pigment dispersing factor receptor c 0.015 0.1924 0.4497
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.002 0.0072
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0028 0.0066
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0196 0.2557 0.5978
Echinococcus multilocularis snurportin 1 0.0321 0.4277 1
Entamoeba histolytica hypothetical protein 0.0077 0.0913 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0043 0.045 0.1909
Brugia malayi MAP kinase sur-1 0.0059 0.0674 0.2399
Brugia malayi MH2 domain containing protein 0.0115 0.1446 0.5144
Schistosoma mansoni ets-related 0.0215 0.2812 0.6573
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0131 0.1664 1
Trypanosoma cruzi hypothetical protein, conserved 0.0115 0.1446 1
Schistosoma mansoni hypothetical protein 0.0047 0.0512 0.1198
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0131 0.1664 0.3891
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.072 0.3708
Echinococcus multilocularis mitogen activated protein kinase 3 0.0059 0.0674 0.1577
Echinococcus multilocularis zinc finger protein 0.0023 0.0173 0.0404
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0019 0.012 0.0281
Brugia malayi hypothetical protein 0.0018 0.0102 0.0364
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0273 0.0728
Echinococcus granulosus lysosomal alpha glucosidase 0.0157 0.2025 0.4735
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.012 0.0281
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0195 0.1112
Echinococcus granulosus mitogen activated protein kinase 0.0059 0.0674 0.1577
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.034 0.1173
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0236 0.0483
Echinococcus granulosus cpg binding protein 0.0036 0.0348 0.0814
Entamoeba histolytica hypothetical protein 0.0024 0.0195 0.1789
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0196 0.2557 0.5978
Schistosoma mansoni tar DNA-binding protein 0.0203 0.2652 0.62
Loa Loa (eye worm) hypothetical protein 0.0103 0.127 0.297
Trichomonas vaginalis penicillin-binding protein, putative 0.0115 0.1446 1
Schistosoma mansoni hypothetical protein 0.0077 0.0913 0.2135
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0164 0.0383
Echinococcus multilocularis beta LACTamase domain containing family member 0.0115 0.1446 0.3381
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.034 0.2142
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0028 0.0066
Onchocerca volvulus 0.0115 0.1446 0.7904
Schistosoma mansoni hypothetical protein 0.0016 0.0085 0.0199
Onchocerca volvulus 0.0032 0.0295 0.1443
Mycobacterium ulcerans aldehyde dehydrogenase 0.0131 0.1664 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.034 0.1208
Loa Loa (eye worm) hypothetical protein 0.0041 0.0426 0.0995
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0295 0.069
Brugia malayi latrophilin 2 splice variant baaae 0.0103 0.127 0.4518
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.034 0.2142
Schistosoma mansoni hypothetical protein 0.0047 0.0512 0.1198
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.012 0.0281
Echinococcus multilocularis inositol monophosphatase 1 0.0043 0.045 0.1052
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0164 0.0382
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0164 0.0892
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0674 0.1577
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0164 0.0382
Brugia malayi Ets-domain containing protein 0.0071 0.0832 0.2957
Echinococcus multilocularis mitogen activated protein kinase 0.0059 0.0674 0.1577
Mycobacterium tuberculosis Conserved protein 0.0115 0.1446 0.1342
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0674 0.452
Schistosoma mansoni hypothetical protein 0.0012 0.0028 0.0066
Trichomonas vaginalis D-aminoacylase, putative 0.0115 0.1446 1
Brugia malayi Inositol-1 0.0043 0.045 0.1601
Schistosoma mansoni cpg binding protein 0.0032 0.0295 0.069
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0111 0.0259
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0412 0.2657
Echinococcus multilocularis expressed protein 0.0019 0.012 0.028
Schistosoma mansoni ran 0.0022 0.0164 0.0382
Onchocerca volvulus 0.0115 0.1446 0.7904
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0071 0.0832 0.1944
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0059 0.0674 0.452
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0217 0.0507
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.034 0.0794
Loa Loa (eye worm) TAR-binding protein 0.0203 0.2652 0.62
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0059 0.0674 0.3914
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.034 0.2142
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0115 0.1446 0.1342
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0059 0.0674 0.1577
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0043 0.045 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0904 0.2113
Schistosoma mansoni cpg binding protein 0.0036 0.0348 0.0814
Onchocerca volvulus Huntingtin homolog 0.0142 0.182 1
Brugia malayi beta-lactamase family protein 0.0115 0.1446 0.5143
Schistosoma mansoni aldehyde dehydrogenase 0.0131 0.1664 0.3891
Trypanosoma brucei glucosidase, putative 0.0035 0.034 0.2142
Mycobacterium ulcerans beta-lactamase 0.0115 0.1446 0.8588
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0111 0.0259
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.034 0.0794
Brugia malayi Bromodomain containing protein 0.0082 0.0992 0.3527
Loa Loa (eye worm) hypothetical protein 0.0115 0.1446 0.3381
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0412 0.0963
Trichomonas vaginalis D-aminoacylase, putative 0.0115 0.1446 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0115 0.1446 0.5143
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 0.1446 0.3381
Brugia malayi hypothetical protein 0.0142 0.182 0.6472
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0512 0.1198
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0196 0.2557 0.5978
Loa Loa (eye worm) hypothetical protein 0.004 0.0412 0.0963
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0217 0.0507
Entamoeba histolytica hypothetical protein 0.0077 0.0913 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.015 0.1924 0.6842
Schistosoma mansoni bromodomain containing protein 0.007 0.0819 0.1914
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0059 0.0674 0.452
Trichomonas vaginalis ferritin, putative 0.0019 0.012 0.0582
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.012 0.028
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0674 0.452
Schistosoma mansoni ferritin 0.0019 0.012 0.028
Leishmania major hypothetical protein, conserved 0.0115 0.1446 0.8659
Loa Loa (eye worm) hypothetical protein 0.0047 0.0512 0.1198
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.045 0.2534
Schistosoma mansoni alpha-glucosidase 0.0135 0.1724 0.4029
Schistosoma mansoni ferritin 0.0019 0.012 0.028
Echinococcus granulosus snurportin 1 0.0321 0.4277 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0196 0.2557 0.9094
Mycobacterium ulcerans hypothetical protein 0.0115 0.1446 0.8588
Loa Loa (eye worm) inositol-1 0.0043 0.045 0.1052
Schistosoma mansoni apoferritin-2 0.0019 0.012 0.028
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0157 0.2025 0.4735
Trichomonas vaginalis penicillin-binding protein, putative 0.0115 0.1446 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0115 0.1446 0.1342
Loa Loa (eye worm) hypothetical protein 0.0013 0.0038 0.0089
Brugia malayi Importin beta-1 subunit 0.003 0.0273 0.097
Mycobacterium ulcerans esterase/lipase LipP 0.0115 0.1446 0.8588
Mycobacterium tuberculosis Conserved protein 0.0115 0.1446 0.1342
Schistosoma mansoni hypothetical protein 0.0047 0.0512 0.1198
Echinococcus granulosus zinc finger protein 0.0023 0.0173 0.0404
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.045 0.2926
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0043 0.045 0.2138
Schistosoma mansoni inositol monophosphatase 0.0043 0.045 0.1052
Leishmania major importin beta-1 subunit, putative 0.0024 0.0195 0.0963
Trichomonas vaginalis ran, putative 0.0022 0.0164 0.0892
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.045 0.2926
Leishmania major hypothetical protein, conserved 0.0027 0.0236 0.1218
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0115 0.1446 0.3381
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0236 0.1406
Loa Loa (eye worm) hypothetical protein 0.0115 0.1446 0.3381
Mycobacterium leprae conserved hypothetical protein 0.0115 0.1446 1
Mycobacterium leprae Probable lipase LipE 0.0115 0.1446 1
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0412 0.0963
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0412 0.1466
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0412 0.0963
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0512 0.1198
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0236 0.6628
Giardia lamblia Kinase, CMGC MAPK 0.0059 0.0674 1
Treponema pallidum bacterioferrin (TpF1) 0.0019 0.012 0.5
Echinococcus multilocularis GA binding protein alpha chain 0.0071 0.0832 0.1944
Plasmodium vivax hypothetical protein, conserved 0.0115 0.1446 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0131 0.1664 0.1563
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0512 0.1198
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0196 0.2557 0.5978
Leishmania major GTP-binding protein, putative 0.0022 0.0164 0.0772
Brugia malayi TAR-binding protein 0.0203 0.2652 0.9433
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0111 0.0259
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0217 0.0507
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0512 0.1198
Entamoeba histolytica hypothetical protein 0.0077 0.0913 1
Echinococcus multilocularis tar DNA binding protein 0.0203 0.2652 0.62
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0131 0.1664 0.3891
Loa Loa (eye worm) hypothetical protein 0.0142 0.182 0.4254
Toxoplasma gondii aldehyde dehydrogenase 0.0131 0.1664 1
Loa Loa (eye worm) hypothetical protein 0.0115 0.1446 0.3381
Schistosoma mansoni hypothetical protein 0.0103 0.127 0.297
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0674 0.452
Mycobacterium tuberculosis Probable esterase LipL 0.0115 0.1446 0.1342
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0164 0.0892
Brugia malayi RNA recognition motif domain containing protein 0.0203 0.2652 0.9433
Loa Loa (eye worm) hypothetical protein 0.006 0.069 0.1614
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0203 0.2652 0.62
Schistosoma mansoni tar DNA-binding protein 0.0203 0.2652 0.62
Schistosoma mansoni zinc finger protein 0.0023 0.0173 0.0404
Brugia malayi beta-lactamase family protein 0.0115 0.1446 0.5143
Schistosoma mansoni hypothetical protein 0.0047 0.0512 0.1198
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0674 0.452
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.045 0.2926
Schistosoma mansoni cpg binding protein 0.0036 0.0348 0.0814
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0115 0.1446 0.3381
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0043 0.045 0.4709
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0164 0.0582
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0236 0.1406
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0236 0.1406
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0412 0.2657
Schistosoma mansoni inositol monophosphatase 0.0043 0.045 0.1052
Loa Loa (eye worm) RNA binding protein 0.0203 0.2652 0.62
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0412 0.0963
Brugia malayi RNA, U transporter 1 0.0086 0.1036 0.3684
Plasmodium vivax importin-beta 2, putative 0.003 0.0273 0.0852
Echinococcus multilocularis cpg binding protein 0.0036 0.0348 0.0814
Echinococcus granulosus GPCR family 2 0.0047 0.0512 0.1198
Brugia malayi CXXC zinc finger family protein 0.0032 0.0295 0.1049
Trichomonas vaginalis D-aminoacylase, putative 0.0115 0.1446 1
Toxoplasma gondii ABC1 family protein 0.0115 0.1446 0.8547
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.034 0.3447
Mycobacterium ulcerans aldehyde dehydrogenase 0.0131 0.1664 1
Onchocerca volvulus Huntingtin homolog 0.0142 0.182 1
Mycobacterium tuberculosis Probable hydrolase 0.0115 0.1446 0.1342
Trypanosoma cruzi ISWI complex protein 0.0016 0.0085 0.0334
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0321 0.4277 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0059 0.0674 0.3914
Onchocerca volvulus 0.0091 0.1112 0.6027
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.015 0.1924 0.6842
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.034 0.2142
Echinococcus granulosus mitogen activated protein kinase 3 0.0059 0.0674 0.1577
Brugia malayi hypothetical protein 0.0027 0.0236 0.0839
Schistosoma mansoni ferritin 0.0019 0.012 0.028
Brugia malayi Ets-domain containing protein 0.0071 0.0832 0.2957
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0077 0.0913 0.2135
Echinococcus granulosus expressed protein 0.0019 0.012 0.028
Echinococcus granulosus ferritin 0.0019 0.012 0.028
Echinococcus granulosus importin subunit beta 1 0.003 0.0273 0.0638
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0512 0.1822
Echinococcus multilocularis ferritin 0.0019 0.012 0.028
Echinococcus granulosus histone lysine methyltransferase setb 0.0019 0.012 0.0281
Schistosoma mansoni alpha glucosidase 0.0035 0.034 0.0794
Echinococcus granulosus inositol monophosphatase 1 0.0043 0.045 0.1052
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.034 0.2142
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0412 0.2657
Loa Loa (eye worm) hypothetical protein 0.0027 0.0236 0.0552
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.034 0.2142
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.045 0.2926
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.2025 0.4735
Schistosoma mansoni apoferritin-2 0.0019 0.012 0.028
Loa Loa (eye worm) hypothetical protein 0.0115 0.1446 0.3381
Echinococcus multilocularis importin subunit beta 1 0.003 0.0273 0.0638
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.034 0.2142
Loa Loa (eye worm) hypothetical protein 0.0115 0.1446 0.3381
Loa Loa (eye worm) fli-1 protein 0.0215 0.2812 0.6573
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0196 0.2557 0.5978
Schistosoma mansoni ferritin 0.0019 0.012 0.028
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0412 0.2657
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0638
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0164 0.0892
Schistosoma mansoni hypothetical protein 0.0022 0.0164 0.0383
Trichomonas vaginalis inositol monophosphatase, putative 0.0043 0.045 0.2926
Schistosoma mansoni alpha-glucosidase 0.0135 0.1724 0.4029
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0059 0.0674 0.452
Plasmodium falciparum importin beta, putative 0.003 0.0273 1
Brugia malayi Bromodomain containing protein 0.0041 0.0425 0.1511
Loa Loa (eye worm) hypothetical protein 0.0019 0.012 0.0281
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0273 0.1668
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0196 0.2557 0.5978
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0674 0.452
Brugia malayi beta-lactamase 0.0115 0.1446 0.5143
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.2025 0.4735
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0059 0.0674 0.3404
Schistosoma mansoni ran 0.0022 0.0164 0.0382
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0115 0.1446 0.8588
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0412 0.0963
Entamoeba histolytica Ran family GTPase 0.0022 0.0164 0.1435
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0115 0.1446 0.1342
Mycobacterium ulcerans lipase LipD 0.0115 0.1446 0.8588
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0038 0.0388 0.2023
Trichomonas vaginalis esterase, putative 0.0115 0.1446 1
Loa Loa (eye worm) hypothetical protein 0.0115 0.1446 0.3381
Trypanosoma cruzi hypothetical protein, conserved 0.0115 0.1446 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0111 0.0259
Entamoeba histolytica hypothetical protein 0.0077 0.0913 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0066 0.0766 0.179
Mycobacterium tuberculosis Probable lipase LipD 0.0115 0.1446 0.1342
Echinococcus granulosus beta LACTamase domain containing family member 0.0115 0.1446 0.3381
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0412 0.23
Echinococcus granulosus tar DNA binding protein 0.0203 0.2652 0.62
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0066 0.0766 0.179
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0038 0.0388 0.0272
Loa Loa (eye worm) hypothetical protein 0.0044 0.0461 0.1077
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0236 0.0565
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0195 0.1112
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.034 0.3447

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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