Detailed information for compound 582710

Basic information

Technical information
  • TDR Targets ID: 582710
  • Name: Deuterium
  • MW: 4.0282 | Formula: D2
  • H donors: 0 H acceptors: 0 LogP: 0 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: [2H][2H]
  • InChi: 1S/H2/h1H/i1+1D
  • InChiKey: UFHFLCQGNIYNRP-VVKOMZTBSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7782-39-0
  • (2)H2
  • CHEBI:29294
  • D2
  • 361860_ALDRICH
  • Deuterium molecule
  • Deuterium, compressed [UN1957] [Flammable gas]
  • Dideuterium
  • Diplogen
  • EINECS 231-952-7
  • HSDB 294
  • Heavy hydrogen
  • Hydrogen, isotope of mass 2
  • Hydrogen-2
  • Hydrogen-d2
  • UN1957
  • 617474_ALDRICH
  • 368407_ALDRICH

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0213 0.0213
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0721 0.0721
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0213 0.0828
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0701 0.0955
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.1284 1
Brugia malayi hypothetical protein 0.001 0.004 0.0054
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.079 0.3165
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.001 0.004 0.004
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.06 0.06
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.0868 0.0868
Brugia malayi Muscleblind-like protein 0.0296 0.4164 0.5674
Loa Loa (eye worm) transcription factor SMAD2 0.0134 0.1829 0.2492
Loa Loa (eye worm) hypothetical protein 0.0013 0.0085 0.0116
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 0.0868 0.1746
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.004 0.004
Schistosoma mansoni lamin 0.0027 0.0296 0.0296
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0113 0.0154
Schistosoma mansoni intermediate filament proteins 0.0027 0.0296 0.0296
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0195 0.2707 0.8039
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0328 0.462 0.9296
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0213 0.0828
Echinococcus granulosus phd:f box containing protein 0.0015 0.012 0.012
Onchocerca volvulus 0.0027 0.0296 0.0879
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0191 0.2652 0.2652
Brugia malayi MH2 domain containing protein 0.0009 0.0033 0.0045
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0829 0.1129
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1284 0.2583
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.004 0.0054
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0213 0.166
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0033 0.0033
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.0721 0.0982
Echinococcus granulosus dna polymerase kappa 0.0022 0.0213 0.0213
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0338 0.0338
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.012 0.0164
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0213 0.0192
Plasmodium vivax SET domain protein, putative 0.003 0.0338 0.045
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.001 0.004 0.0054
Loa Loa (eye worm) hypothetical protein 0.0017 0.0148 0.0201
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.012 0.012
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0213 0.0213
Schistosoma mansoni lamin 0.0027 0.0296 0.0296
Loa Loa (eye worm) hypothetical protein 0.0296 0.4164 0.5674
Echinococcus multilocularis muscleblind protein 1 0.0296 0.4164 0.4164
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0231 0.0465
Echinococcus granulosus GPCR family 2 0.0018 0.0156 0.0156
Onchocerca volvulus 0.003 0.0338 0.1005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0328 0.462 0.9296
Schistosoma mansoni jumonji domain containing protein 0.0015 0.012 0.012
Onchocerca volvulus 0.0023 0.0231 0.0686
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.004 0.004
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.06 0.06
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0586 0.1179
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.079 0.079
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0213 0.0828
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0231 0.0315
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.079 0.079
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0156 0.0213
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0231 0.0405
Schistosoma mansoni regulator of G protein signaling 0.001 0.004 0.004
Leishmania major DNA polymerase eta, putative 0.0022 0.0213 0.0192
Giardia lamblia Macrophage migration inhibitory factor 0.0352 0.497 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0096 0.1284 0.1749
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0213 0.166
Loa Loa (eye worm) hypothetical protein 0.0027 0.0289 0.0394
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0322 0.0322
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.079 0.079
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1284 0.2583
Loa Loa (eye worm) hypothetical protein 0.0013 0.0092 0.0125
Schistosoma mansoni protein phosphatase 2C 0.0015 0.012 0.012
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1284 0.2583
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0829 0.0829
Loa Loa (eye worm) hypothetical protein 0.0023 0.0231 0.0315
Trichomonas vaginalis macrophage migration inhibitory factor, mif, putative 0.0352 0.497 1
Loa Loa (eye worm) Smad1 0.0009 0.0033 0.0045
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.004 0.0054
Schistosoma mansoni smad1 5 8 and 0.0009 0.0033 0.0033
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0213 0.029
Mycobacterium ulcerans hypothetical protein 0.0023 0.0231 0.0405
Schistosoma mansoni hypothetical protein 0.0295 0.4145 0.4145
Loa Loa (eye worm) hypothetical protein 0.0296 0.4164 0.5674
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0231 0.0315
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0033 0.0045
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0213 0.166
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0829 0.0829
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.0868 0.0868
Echinococcus multilocularis musashi 0.0027 0.0296 0.0296
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0328 0.462 0.9296
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0868 0.6757
Onchocerca volvulus 0.0027 0.0296 0.0879
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.06 0.06
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0721 0.0721
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0213 0.029
Schistosoma mansoni hypothetical protein 0.0018 0.0156 0.0156
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0231 0.0405
Brugia malayi jmjC domain containing protein 0.0015 0.012 0.0164
Loa Loa (eye worm) hypothetical protein 0.0017 0.0148 0.0201
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0231 0.0405
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0213 0.166
Schistosoma mansoni smad1 5 8 and 0.0009 0.0033 0.0033
Brugia malayi regulator of G-protein signaling egl-10 0.001 0.004 0.0054
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0328 0.462 0.9296
Schistosoma mansoni kinase 0.0049 0.0604 0.0604
Loa Loa (eye worm) hypothetical protein 0.0018 0.0156 0.0213
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0156 0.0156
Echinococcus multilocularis microtubule associated protein 2 0.0702 1 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.012 0.0164
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0231 0.0467
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0213 0.0828
Brugia malayi jmjC domain containing protein 0.0057 0.0721 0.0982
Brugia malayi jmjC domain containing protein 0.0015 0.012 0.0164
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0706 0.0962
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0328 0.462 0.9296
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0706 0.0962
Brugia malayi MH1 domain containing protein 0.0009 0.0033 0.0045
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0213 0.166
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.015 0.2064 0.2812
Schistosoma mansoni smad1 5 8 and 0.0009 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0272 0.382 0.5205
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1284 0.2583
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0328 0.462 0.9296
Loa Loa (eye worm) hypothetical protein 0.0038 0.0452 0.0615
Loa Loa (eye worm) hypothetical protein 0.0017 0.0148 0.0201
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.016 0.2207 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.016 0.2207 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0721 0.0721
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0213 0.0828
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0156 0.0156
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.06 0.178
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.06 0.06
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0231 0.0405
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1284 0.2583
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0054
Loa Loa (eye worm) hypothetical protein 0.0017 0.0148 0.0201
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0015 0.012 0.012
Echinococcus granulosus survival motor neuron protein 1 0.0272 0.382 0.382
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0338 0.0338
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0213 0.038
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0586 0.1179
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0213 0.0213
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0148 0.0065
Loa Loa (eye worm) macrophage migration inhibitory factor 0.0352 0.497 0.6772
Schistosoma mansoni survival motor neuron protein 0.0056 0.0701 0.0701
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.015 0.2064 0.2812
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0213 0.0828
Schistosoma mansoni Smad4 0.0009 0.0033 0.0033
Brugia malayi follicle stimulating hormone receptor 0.0517 0.734 1
Schistosoma mansoni hypothetical protein 0.0018 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0017 0.0148 0.0201
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0033 0.0033
Echinococcus granulosus dna polymerase eta 0.0022 0.0213 0.0213
Brugia malayi jmjC domain containing protein 0.0057 0.0721 0.0982
Echinococcus multilocularis GPCR, family 2 0.0018 0.0156 0.0156
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.06 0.0817
Echinococcus multilocularis geminin 0.0164 0.2257 0.2257
Giardia lamblia Fructose-bisphosphate aldolase 0.0328 0.462 0.9264
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0033 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0352 0.497 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0338 0.0461
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0706 0.0962
Brugia malayi mbt repeat family protein 0.0049 0.06 0.0817
Loa Loa (eye worm) hypothetical protein 0.0027 0.0296 0.0404
Entamoeba histolytica serine/threonine protein kinase, putative 0.0096 0.1284 0.2583
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0338 0.0338
Loa Loa (eye worm) MBCTL1 0.0055 0.0696 0.0949
Brugia malayi N-terminal motif family protein 0.0195 0.2707 0.3689
Brugia malayi MH2 domain containing protein 0.0134 0.1829 0.2492
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0148 0.0057
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0231 0.0405
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.012 0.012
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0868 0.6434
Schistosoma mansoni DNA polymerase eta 0.0022 0.0213 0.0213
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0231 0.0229
Brugia malayi Smad1 0.0009 0.0033 0.0045
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.079 0.312
Loa Loa (eye worm) hypothetical protein 0.0023 0.0231 0.0315
Echinococcus multilocularis phd:f box containing protein 0.0015 0.012 0.012
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.004 0.004
Trypanosoma brucei unspecified product 0.0022 0.0213 0.0828
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0054
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.012 0.0164
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.06 0.06
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0231 0.0405
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0231 0.0465
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.0868 0.1182
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0096 0.1284 0.24
Schistosoma mansoni phosphatidylserine receptor 0.0015 0.012 0.012
Echinococcus multilocularis lamin 0.0027 0.0296 0.0296
Brugia malayi jmjC domain containing protein 0.0015 0.012 0.0164
Brugia malayi TAR-binding protein 0.0064 0.0829 0.1129
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0033 0.0033
Echinococcus granulosus Pleckstrin G protein interacting region 0.001 0.004 0.004
Leishmania major macrophage migration inhibitory factor-like protein 0.0352 0.497 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0338 0.0338
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.012 0.0935
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.06 0.06
Trypanosoma brucei polo-like protein kinase 0.0096 0.1284 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0156 0.0213
Echinococcus granulosus geminin 0.0164 0.2257 0.2257
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0296 0.0404
Schistosoma mansoni microtubule-associated protein tau 0.0702 1 1
Brugia malayi jmjC domain containing protein 0.0015 0.012 0.0164
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0148 0.0057
Brugia malayi mbt repeat family protein 0.0049 0.06 0.0817
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0696 0.0696
Leishmania major macrophage migration inhibitory factor-like protein 0.0352 0.497 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0213 0.0429
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1284 0.2583
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.012 0.0935
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0696 0.0696
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0829 0.1129
Onchocerca volvulus 0.001 0.004 0.0118
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0213 0.0828
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0338 0.0338
Schistosoma mansoni dishevelled 0.001 0.004 0.004
Schistosoma mansoni dishevelled 0.001 0.004 0.004
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0015 0.012 0.0163
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0113 0.0154
Loa Loa (eye worm) DIX domain-containing protein 0.001 0.004 0.0054
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0338 0.0606
Brugia malayi hypothetical protein 0.0272 0.382 0.5205
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0191 0.2652 0.2652
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0092 0.0092
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0338 0.0338
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0696 0.0696
Entamoeba histolytica macrophage migration inhibitory factor-like protein 0.0352 0.497 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0696 0.0949
Schistosoma mansoni hypothetical protein 0.0164 0.2257 0.2257
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0829 0.0829
Loa Loa (eye worm) hypothetical protein 0.0013 0.0085 0.0116
Brugia malayi serine/threonine-protein kinase plk-2 0.0096 0.1284 0.1749
Brugia malayi hypothetical protein 0.001 0.004 0.0054
Echinococcus granulosus intermediate filament protein 0.0027 0.0296 0.0296
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0829 0.1129
Echinococcus granulosus Smad4 0.0009 0.0033 0.0033
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0328 0.462 0.9296
Loa Loa (eye worm) hypothetical protein 0.0022 0.0213 0.029
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0213 0.0828
Schistosoma mansoni dep domain containing protein 0.001 0.004 0.004
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0092 0.0092
Toxoplasma gondii macrophage migration inhibitory factor, putative 0.0352 0.497 1
Schistosoma mansoni smad 0.0009 0.0033 0.0033
Echinococcus granulosus smad 0.0009 0.0033 0.0033
Echinococcus multilocularis dna polymerase eta 0.0022 0.0213 0.0213
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.004 0.004
Brugia malayi Bm-MIF-1, identical 0.0352 0.497 0.6772
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.012 0.012
Brugia malayi intermediate filament protein 0.0027 0.0296 0.0404
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0156 0.0156
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0033 0.0045
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0721 0.0721
Schistosoma mansoni hypothetical protein 0.0038 0.0452 0.0452
Schistosoma mansoni hypothetical protein 0.0056 0.0701 0.0701
Brugia malayi MH1 domain containing protein 0.0009 0.0033 0.0045
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0231 0.0229
Echinococcus granulosus muscleblind protein 0.0296 0.4164 0.4164
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0868 0.6757
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0156 0.0156
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.004 0.004
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0156 0.0213
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0328 0.462 0.9296
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0213 0.0317
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0231 0.0465
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.079 0.312
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0213 0.0828
Onchocerca volvulus 0.0056 0.0701 0.2081
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0231 0.0405
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0213 0.0828
Schistosoma mansoni hypothetical protein 0.0018 0.0156 0.0156
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0296 0.0404
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0054
Plasmodium falciparum macrophage migration inhibitory factor 0.0352 0.497 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.012 0.0164
Echinococcus multilocularis muscleblind protein 0.0296 0.4164 0.4164
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0213 0.0213
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0231 0.0315
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.0868 0.1182
Brugia malayi Pre-SET motif family protein 0.0212 0.2947 0.4015
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.079 0.1382
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0231 0.0467
Loa Loa (eye worm) hypothetical protein 0.0195 0.2707 0.3689
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0213 0.0828
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.079 0.312
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0721 0.0721
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0696 0.0696
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0213 0.029
Echinococcus multilocularis lamin dm0 0.0027 0.0296 0.0296
Trichomonas vaginalis set domain proteins, putative 0.0241 0.3368 0.6776
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0015 0.012 0.012
Brugia malayi DIX domain containing protein 0.001 0.004 0.0054
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.079 0.079
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0829 0.0829
Echinococcus multilocularis survival motor neuron protein 1 0.0272 0.382 0.382
Loa Loa (eye worm) RNA binding protein 0.0064 0.0829 0.1129
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0461 0.0461
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.004 0.004
Echinococcus multilocularis smad 0.0009 0.0033 0.0033
Schistosoma mansoni hypothetical protein 0.0018 0.0156 0.0156
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0096 0.1284 0.1284
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0148 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0213 0.0828
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0213 0.0828
Brugia malayi Pre-SET motif family protein 0.003 0.0338 0.0461
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0213 0.0429
Loa Loa (eye worm) hypothetical protein 0.0056 0.0706 0.0962
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 0.0868 0.1541
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0213 0.0828
Schistosoma mansoni hypothetical protein 0.0164 0.2257 0.2257
Leishmania major DNA polymerase kappa, putative 0.0022 0.0213 0.0192
Onchocerca volvulus Serine\/threonine kinase homolog 0.0096 0.1284 0.3812
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0296 0.0404
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.016 0.2207 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.0868 0.0868
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.001 0.004 0.0118
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0517 0.734 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.1284 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0213 0.038
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0829 0.0829
Loa Loa (eye worm) hypothetical protein 0.0015 0.012 0.0164
Echinococcus granulosus lamin dm0 0.0027 0.0296 0.0296
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.012 0.012
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.001 0.004 0.004
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0213 0.0213
Schistosoma mansoni phd/f-box containing protein 0.0015 0.012 0.012
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1284 0.2583
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0015 0.012 0.012
Onchocerca volvulus 0.0241 0.3368 1
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.012 0.012
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0231 0.0229
Echinococcus granulosus lysine specific demethylase 5A 0.0057 0.0721 0.0721
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0096 0.1284 0.1284
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.079 0.1522
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0213 0.0429
Echinococcus granulosus tar DNA binding protein 0.0064 0.0829 0.0829
Giardia lamblia Kinase, PLK 0.0096 0.1284 0.2251
Loa Loa (eye worm) hypothetical protein 0.0015 0.012 0.0164
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.012 0.012
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.004 0.004
Echinococcus multilocularis Smad4 0.0009 0.0033 0.0033
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0696 0.0696
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0015 0.012 0.0031
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0328 0.462 0.9296
Onchocerca volvulus 0.0049 0.06 0.178
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0461 0.0461
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0213 0.0317
Echinococcus granulosus lamin 0.0027 0.0296 0.0296
Brugia malayi MH2 domain containing protein 0.0009 0.0033 0.0045
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.06 0.06
Plasmodium vivax macrophage migration inhibitory factor, putative 0.0352 0.497 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0696 0.0949
Loa Loa (eye worm) MH2 domain-containing protein 0.0134 0.1829 0.2492
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0721 0.0721
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.004 0.004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0338 0.0338
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0452 0.0615
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0212 0.2947 0.4015
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0328 0.462 0.9296
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0829 0.0829
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0015 0.012 0.0163
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.1284 0.1284
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0023 0.0231 0.0315
Brugia malayi RNA binding protein 0.0064 0.0829 0.1129
Loa Loa (eye worm) hypothetical protein 0.0049 0.06 0.0817
Treponema pallidum fructose-bisphosphate aldolase 0.0328 0.462 0.5
Schistosoma mansoni z-protein (S1r protein) 0.001 0.004 0.004

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

42 literature references were collected for this gene.

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