Detailed information for compound 582978

Basic information

Technical information
  • TDR Targets ID: 582978
  • Name: (1R,2S)-1-(1,3-benzodioxol-5-yl)-1-morpholino -propan-2-ol
  • MW: 265.305 | Formula: C14H19NO4
  • H donors: 1 H acceptors: 1 LogP: 0.98 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@@H]([C@@H](c1ccc2c(c1)OCO2)N1CCOCC1)O
  • InChi: 1S/C14H19NO4/c1-10(16)14(15-4-6-17-7-5-15)11-2-3-12-13(8-11)19-9-18-12/h2-3,8,10,14,16H,4-7,9H2,1H3/t10-,14-/m0/s1
  • InChiKey: KFSXLIJSXOJBCB-HZMBPMFUSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (1R,2S)-1-(1,3-benzodioxol-5-yl)-1-morpholino-2-propanol
  • (1R,2S)-1-(1,3-benzodioxol-5-yl)-1-morpholin-4-yl-propan-2-ol
  • (1R,2S)-1-(1,3-benzodioxol-5-yl)-1-morpholin-4-ylpropan-2-ol
  • filenadol
  • (1R,2S)-1-(1,3-benzodioxol-5-yl)-1-morpholinopropan-2-ol
  • 78168-92-0
  • (+-)-erythro-alpha-Methyl-beta(3,4-(methylenedioxy)phenyl)-4-morpholineethanol
  • (+-)-erythro-alpha-Methyl-beta-(3,4-(methylenedioxy)phenyl)-4-morpholineethanol
  • (R*,S*)-(+-)-beta-1,3-Benzodioxol-5-yl-alpha-methyl-4-morpholineethanol
  • 4-Morpholineethanol, beta-1,3-benzodioxol-5-yl-alpha-methyl-, (R*,S*)-(+-)-
  • FI-2024
  • Filenadol [INN]
  • Filenadolum [INN-Latin]
  • d,l-erythro-1-(3,4-Methylenedioxyphenyl)-1-morpholinopropan-2-ol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.008 0.0242 0.0274
Schistosoma mansoni topbp1 0.0022 0.0008 0.0009
Loa Loa (eye worm) fli-1 protein 0.022 0.0804 0.0801
Leishmania major DNA polymerase eta, putative 0.0035 0.006 0.1254
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0099 0.0317 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0007 0.0007
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0039 0.0076 0.162
Echinococcus granulosus replication factor c subunit 1 0.0022 0.0008 0.0009
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0132 0.0451 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0007 0.0003
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0007 0.0007
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0096 0.0305 0.0302
Echinococcus multilocularis pyruvate kinase 0.0039 0.0076 0.0086
Trypanosoma cruzi transcription factor btf3, putative 0.0036 0.0064 0.1377
Echinococcus multilocularis sphingomyelin synthase protein 1 0.0131 0.0446 0.0506
Loa Loa (eye worm) hypothetical protein 0.2507 1 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0093 0.0295 0.6517
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0076 0.0073
Loa Loa (eye worm) hypothetical protein 0.0126 0.0426 0.0423
Schistosoma mansoni patched 1 0.0096 0.0305 0.0346
Toxoplasma gondii NAC domain-containing protein 0.0036 0.0064 0.1442
Leishmania major pyruvate kinase 0.0039 0.0076 0.162
Schistosoma mansoni hypothetical protein 0.0092 0.0291 0.033
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0006 0.0049
Echinococcus granulosus dna polymerase eta 0.0049 0.0119 0.0135
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0126 0.0122
Schistosoma mansoni hypothetical protein 0.0092 0.0291 0.033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0007 0.0003
Mycobacterium ulcerans acyl-CoA synthetase 0.0039 0.0076 0.162
Brugia malayi AMP-binding enzyme family protein 0.0039 0.0076 0.0073
Brugia malayi AMP-binding enzyme family protein 0.0132 0.0451 0.0448
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0064 0.1377
Echinococcus multilocularis protein patched 0.0096 0.0305 0.0346
Loa Loa (eye worm) hypothetical protein 0.0049 0.0119 0.0115
Loa Loa (eye worm) hypothetical protein 0.0022 0.0008 0.0005
Echinococcus granulosus sphingomyelin synthase protein 1 0.0131 0.0446 0.0506
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0006 0.0049
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0007 0.0003
Toxoplasma gondii propionate-CoA ligase 0.0039 0.0076 0.1701
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.0223 0.0817 0.0814
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0006 0.0049
Toxoplasma gondii pyruvate kinase PyK1 0.0039 0.0076 0.1702
Entamoeba histolytica acyl-coA synthetase, putative 0.0132 0.0451 0.5502
Brugia malayi AMP-binding enzyme family protein 0.0132 0.0451 0.0448
Loa Loa (eye worm) hypothetical protein 0.0131 0.0446 0.0443
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0076 0.1561
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0007 0.0007
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0003 0.0076
Brugia malayi ecdysteroid receptor 0.0022 0.0007 0.0003
Brugia malayi DKFZp564C0469 protein 0.0022 0.0008 0.0005
Loa Loa (eye worm) hypothetical protein 0.0132 0.0451 0.0448
Echinococcus granulosus pyruvate kinase 0.0039 0.0076 0.0086
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0006 0.0049
Mycobacterium ulcerans acyl-CoA synthetase 0.0132 0.0451 1
Loa Loa (eye worm) hypothetical protein 0.0117 0.0392 0.0388
Mycobacterium ulcerans acyl-CoA synthetase 0.0039 0.0076 0.162
Mycobacterium ulcerans acyl-CoA synthetase 0.0039 0.0076 0.162
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0039 0.0076 0.1638
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0022 0.0008 1
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0039 0.0076 0.0073
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0022 0.0008 0.0105
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0006 0.0006
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0131 0.0446 0.0443
Echinococcus multilocularis Niemann Pick C1 protein 0.0319 0.1202 0.1364
Giardia lamblia Pyruvate kinase 0.0039 0.0076 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0006 0.0049
Trypanosoma brucei transcription factor BTF3, putative 0.0036 0.0064 0.1377
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0039 0.0076 0.1701
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0131 0.0446 1
Echinococcus granulosus survival motor neuron protein 1 0.0526 0.2035 0.231
Echinococcus multilocularis microtubule associated protein 2 0.2211 0.8811 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0076 0.0073
Plasmodium falciparum replication factor C subunit 1, putative 0.0022 0.0008 0.018
Schistosoma mansoni transcription factor LCR-F1 0.008 0.0242 0.0274
Schistosoma mansoni hypothetical protein 0.0092 0.0291 0.033
Loa Loa (eye worm) hypothetical protein 0.0131 0.0446 0.0443
Brugia malayi nuclear receptor NHR-88 0.0022 0.0007 0.0003
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0039 0.0076 0.1638
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0003 0.0004
Leishmania major 4-coumarate:coa ligase-like protein 0.0132 0.0451 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0008 0.0005
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0007 0.0007
Entamoeba histolytica hypothetical membrane-spanning protein 0.0131 0.0446 0.544
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0093 0.0295 0.6517
Brugia malayi nuclear hormone receptor 0.0022 0.0007 0.0003
Mycobacterium leprae Probable pyruvate kinase PykA 0.0039 0.0076 0.1533
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0007 0.0003
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0007 0.0007
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0035 0.006 0.1334
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0039 0.0076 0.162
Trichomonas vaginalis conserved hypothetical protein 0.0131 0.0446 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0006 0.0049
Plasmodium falciparum basic transcription factor 3b, putative 0.0036 0.0064 0.1442
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0007 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0006 0.0049
Trypanosoma cruzi DNA polymerase eta, putative 0.0035 0.006 0.1268
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0039 0.0076 0.162
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0022 0.0008 0.0105
Schistosoma mansoni DNA ligase IV 0.0022 0.0008 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.0099 0.0317 0.0314
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0006 0.0049
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0132 0.0451 1
Leishmania major pyruvate kinase 0.0039 0.0076 0.162
Entamoeba histolytica hypothetical protein 0.0131 0.0446 0.544
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0007 0.0007
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0039 0.0076 0.162
Trypanosoma cruzi transcription factor btf3, putative 0.0036 0.0064 0.1377
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0007 0.0007
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0039 0.0076 0.162
Echinococcus multilocularis dna polymerase eta 0.0049 0.0119 0.0135
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0008 0.0105
Trypanosoma brucei pyruvate kinase 1 0.0039 0.0076 0.1639
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0223 0.0817 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0039 0.0076 0.162
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.0305 0.6812
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0006 0.0027
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0131 0.0446 1
Schistosoma mansoni survival motor neuron protein 0.0107 0.0351 0.0399
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.0099 0.0317 0.0314
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0132 0.0451 1
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0039 0.0076 0.0086
Brugia malayi beta-NAC-like protein 0.0036 0.0064 0.0061
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0006 0.0049
Loa Loa (eye worm) hypothetical protein 0.0051 0.0126 0.0122
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0039 0.0076 0.162
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0003
Onchocerca volvulus 0.0132 0.0451 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0039 0.0076 0.1639
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0006 0.0049
Loa Loa (eye worm) hypothetical protein 0.0022 0.0008 0.0005
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0006 0.0049
Echinococcus multilocularis sterol regulatory element binding protein 0.0096 0.0305 0.0346
Loa Loa (eye worm) hypothetical protein 0.0099 0.0317 0.0314
Trichomonas vaginalis antibiotic synthetase, putative 0.0039 0.0076 0.1638
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0007 0.0007
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0006 0.0049
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0039 0.0076 0.162
Trypanosoma cruzi pyruvate kinase 2, putative 0.0039 0.0076 0.1639
Entamoeba histolytica hypothetical protein 0.008 0.0242 0.293
Onchocerca volvulus 0.0039 0.0076 0.1561
Loa Loa (eye worm) hypothetical protein 0.0132 0.0451 0.0448
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0007 0.0007
Onchocerca volvulus 0.0022 0.0008 0.0034
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0039 0.0076 0.162
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0132 0.0451 1
Schistosoma mansoni acetyl-CoA synthetase 0.0039 0.0076 0.0086
Mycobacterium ulcerans acyl-CoA synthetase 0.0039 0.0076 0.162
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0006 0.0006
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0076 0.0073
Echinococcus multilocularis Niemann Pick C1 protein 0.0223 0.0817 0.0927
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0099 0.0317 0.7001
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0039 0.0076 0.0073
Schistosoma mansoni pyruvate kinase 0.0039 0.0076 0.0086
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0022 0.0008 0.0105
Loa Loa (eye worm) hypothetical protein 0.0131 0.0446 0.0443
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0131 0.0446 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0039 0.0076 0.1638
Echinococcus granulosus microtubule associated protein 2 0.2211 0.8811 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0039 0.0076 0.0073
Loa Loa (eye worm) pyruvate kinase-PB 0.0027 0.0029 0.0025
Echinococcus granulosus expressed conserved protein 0.021 0.0763 0.0866
Loa Loa (eye worm) oxidoreductase 0.0039 0.0076 0.0073
Schistosoma mansoni ets-related 0.022 0.0804 0.0913
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0039 0.0076 0.0891
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0003 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0008 0.0105
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0039 0.0076 0.162
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0007 0.0003
Echinococcus granulosus pyruvate kinase 0.0039 0.0076 0.0086
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0007 0.0003
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0006 0.0006
Onchocerca volvulus 0.0039 0.0076 0.1561
Entamoeba histolytica acyl-CoA synthetase, putative 0.0132 0.0451 0.5502
Echinococcus granulosus sterol regulatory element binding protein 0.0096 0.0305 0.0346
Mycobacterium ulcerans acetyl-CoA synthetase 0.0039 0.0076 0.162
Brugia malayi ImpB/MucB/SamB family protein 0.0049 0.0119 0.0115
Brugia malayi topoisomerase 0.0022 0.0008 0.0005
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0039 0.0076 0.162
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0003
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0072 0.0211 0.0208
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0064 0.1377
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0132 0.0451 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0227 0.0831 0.0943
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0007 0.0003
Trypanosoma brucei inositol phosphorylceramide synthase 0.0131 0.0446 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0008 0.0005
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0007 0.0007
Trypanosoma brucei pyruvate kinase 1, putative 0.0039 0.0076 0.1639
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0039 0.0076 0.0073
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0007 0.0007
Mycobacterium ulcerans acyl-CoA synthetase 0.0039 0.0076 0.162
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.0022 0.0008 0.0005
Trichomonas vaginalis pyruvate kinase, putative 0.0039 0.0076 0.1639
Schistosoma mansoni coup transcription factor 0.0022 0.0007 0.0007
Echinococcus multilocularis survival motor neuron protein 1 0.0526 0.2035 0.231
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0006 0.0049
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0006 0.0006
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0131 0.0446 1
Leishmania major DNA polymerase eta, putative 0.0049 0.0119 0.2573
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0076 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0064 0.1377
Toxoplasma gondii ATPase, AAA family protein 0.0022 0.0008 0.018
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0076 0.1561
Plasmodium falciparum acyl-CoA synthetase 0.0099 0.0317 0.7103
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0039 0.0076 0.162
Trichomonas vaginalis pyruvate kinase, putative 0.0039 0.0076 0.1639
Leishmania major phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0131 0.0446 0.9887
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0007 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0006 0.0049
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0006 0.0049
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0007 0.0007
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0039 0.0076 0.1638
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0895 0.3517 0.3992
Brugia malayi AMP-binding enzyme family protein 0.0039 0.0076 0.0073
Mycobacterium ulcerans acyl-CoA synthetase 0.0132 0.0451 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0093 0.0295 0.6517
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0061 0.0057
Chlamydia trachomatis pyruvate kinase 0.0039 0.0076 0.2199
Echinococcus multilocularis pyruvate kinase 0.0039 0.0076 0.0086
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0039 0.0076 0.162
Echinococcus multilocularis transcription factor btf3 0.0036 0.0064 0.0073
Echinococcus multilocularis replication factor c subunit 1 0.0022 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.0027 0.0029 0.0025
Brugia malayi Fli-1 protein 0.022 0.0804 0.0801
Trypanosoma cruzi DNA polymerase eta, putative 0.0049 0.0119 0.2602
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0007 0.0007
Trichomonas vaginalis replication factor C large subunit, putative 0.0022 0.0008 0.0105
Entamoeba histolytica hypothetical protein 0.008 0.0242 0.293
Onchocerca volvulus Huntingtin homolog 0.0126 0.0426 0.9432
Brugia malayi hypothetical protein 0.0126 0.0426 0.0423
Echinococcus multilocularis pyruvate kinase 0.0031 0.0043 0.0049
Trypanosoma cruzi FHA domain containing protein, putative 0.0022 0.0008 0.0105
Trypanosoma brucei ceramide phosphorylethanolamine synthase 0.0131 0.0446 1
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0131 0.0446 1
Brugia malayi hypothetical protein 0.0022 0.0008 0.0005
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0039 0.0076 0.1638
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0039 0.0076 0.162
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0039 0.0076 0.1701
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0006 0.0049
Schistosoma mansoni gabp alpha 0.0072 0.0211 0.024
Mycobacterium ulcerans acyl-CoA synthetase 0.0039 0.0076 0.162
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0039 0.0076 0.162
Schistosoma mansoni DNA polymerase eta 0.0049 0.0119 0.0135
Brugia malayi AMP-binding enzyme family protein 0.0039 0.0076 0.0073
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0022 0.0008 0.0005
Brugia malayi AMP-binding enzyme family protein 0.0039 0.0076 0.0073
Schistosoma mansoni hypothetical protein 0.0107 0.0351 0.0399
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0132 0.0451 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0107 0.0351 0.0348
Plasmodium vivax pyruvate kinase, putative 0.0039 0.0076 0.1702
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0007 0.0007
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0006 0.0049
Mycobacterium ulcerans hypothetical protein 0.0132 0.0451 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0006 0.0002
Schistosoma mansoni ap endonuclease 0.0021 0.0003 0.0004
Plasmodium vivax basic transcription factor 3b, putative 0.0036 0.0064 0.1442
Mycobacterium ulcerans acyl-CoA synthetase 0.0132 0.0451 1
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0039 0.0076 0.1532
Mycobacterium ulcerans pyruvate kinase 0.0039 0.0076 0.162
Toxoplasma gondii hypothetical protein 0.0131 0.0446 1
Onchocerca volvulus 0.0107 0.0351 0.7757
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0022 0.0008 0.0105
Brugia malayi Pyruvate kinase, M2 isozyme 0.0039 0.0076 0.0073
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0131 0.0446 1
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0007 0.0007
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0039 0.0076 0.1701
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0006 0.0049
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0022 0.0008 0.0105
Schistosoma mansoni spingomyelin synthetase-related 0.0131 0.0446 0.0506
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0003
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0006 0.0002
Echinococcus granulosus dna polymerase kappa 0.0021 0.0006 0.0006
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0057
Echinococcus granulosus Niemann Pick C1 protein 0.0223 0.0817 0.0927
Brugia malayi hypothetical protein 0.0526 0.2035 0.2032
Toxoplasma gondii exonuclease III APE 0.0021 0.0003 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0008 0.0105
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0003
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0039 0.0076 0.162
Schistosoma mansoni transcription factor btf3 0.0036 0.0064 0.0073
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0007 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0007 0.0003
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0006 0.0006
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.008 0.0242 0.0274
Leishmania major basic transcription factor 3a, putative 0.0036 0.0064 0.1361
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0022 0.0008 0.0179
Brugia malayi Sphingomyelin synthase-related 1 0.0131 0.0446 0.0443
Onchocerca volvulus 0.0039 0.0076 0.1561
Brugia malayi CHE-14 protein 0.0096 0.0305 0.0302
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0132 0.0451 1
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0131 0.0446 0.0443
Plasmodium vivax sphingomyelin synthase 1, putative 0.0131 0.0446 1
Entamoeba histolytica hypothetical protein 0.0131 0.0446 0.544
Leishmania major acetyl-CoA synthetase, putative 0.0039 0.0076 0.162
Schistosoma mansoni microtubule-associated protein tau 0.2211 0.8811 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0223 0.0817 0.0814
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0003 0.0445
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0039 0.0076 0.1532
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0126 0.0122
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0039 0.0076 0.1638
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0039 0.0076 0.162
Plasmodium vivax sphingomyelin synthase 2, putative 0.0131 0.0446 1
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0039 0.0076 0.162
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0003
Brugia malayi hypothetical protein 0.0022 0.0008 0.0005
Schistosoma mansoni topbp1 0.0022 0.0008 0.0009
Leishmania major 4-coumarate:coa ligase-like protein 0.0132 0.0451 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0006 0.0049
Schistosoma mansoni hypothetical protein 0.008 0.0242 0.0274
Onchocerca volvulus 0.0039 0.0076 0.1561
Giardia lamblia Replication factor C, subunit 1 0.0022 0.0008 0.1055
Brugia malayi steroid hormone receptor 0.0022 0.0007 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0006 0.0049
Leishmania major 4-coumarate:coa ligase-like protein 0.0132 0.0451 1
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0007 0.0003
Schistosoma mansoni chromosome transmission fidelity factor 0.0022 0.0008 0.0009
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0007 0.0003
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 3 0.0131 0.0446 0.0443
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0008 0.0105
Plasmodium falciparum pyruvate kinase 0.0039 0.0076 0.1702
Loa Loa (eye worm) hypothetical protein 0.0099 0.0317 0.0314
Brugia malayi hypothetical protein 0.008 0.0242 0.0238
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0039 0.0076 0.162
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0039 0.0076 0.1532
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0007 0.0003
Echinococcus multilocularis expressed conserved protein 0.021 0.0763 0.0866
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0008 0.0105
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0006 0.0049
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0022 0.0008 0.0057
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0007 0.0007
Entamoeba histolytica hypothetical protein 0.008 0.0242 0.293
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0007 0.0007
Entamoeba histolytica acyl-CoA synthetase, putative 0.0132 0.0451 0.5502
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0007 0.0007
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0008 0.0105
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0093 0.0295 0.6517
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0126 0.0122
Schistosoma mansoni pyruvate kinase 0.0039 0.0076 0.0086
Loa Loa (eye worm) hypothetical protein 0.0132 0.0451 0.0448
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0131 0.0446 0.0443
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0006 0.0049
Echinococcus granulosus transcription factor btf3 0.0036 0.0064 0.0073
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0007 0.0007
Entamoeba histolytica hypothetical protein 0.0131 0.0446 0.544
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0131 0.0446 1
Entamoeba histolytica hypothetical protein 0.008 0.0242 0.293
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0007 0.0007
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0039 0.0076 0.0086
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0131 0.0446 1
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0022 0.0008 0.0105
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0039 0.0076 0.162
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0006 0.0049
Loa Loa (eye worm) hypothetical protein 0.0099 0.0317 0.0314
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0007 0.0007
Brugia malayi Ets-domain containing protein 0.0072 0.0211 0.0208
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0131 0.0446 1
Plasmodium falciparum sphingomyelin synthase 2, putative 0.0131 0.0446 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0008 0.0005
Entamoeba histolytica hypothetical protein 0.0131 0.0446 0.544
Trypanosoma brucei unspecified product 0.0021 0.0006 0.0049
Entamoeba histolytica transcription factor BTF3, putative 0.0036 0.0064 0.0749
Echinococcus granulosus nibrin 0.0022 0.0008 0.0009
Treponema pallidum DNA ligase (lig) 0.0022 0.0008 1
Trichomonas vaginalis hypothetical protein 0.0131 0.0446 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0099 0.0317 0.7001
Loa Loa (eye worm) hypothetical protein 0.0039 0.0076 0.0073
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0033 0.0054 0.1136
Loa Loa (eye worm) hypothetical protein 0.0062 0.0169 0.0166
Entamoeba histolytica hypothetical protein 0.0022 0.0008 0.0057
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0076 0.1561
Schistosoma mansoni hypothetical protein 0.0092 0.0291 0.033
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0132 0.0451 1
Schistosoma mansoni ap endonuclease 0.0021 0.0003 0.0004
Brugia malayi AMP-binding enzyme family protein 0.0132 0.0451 0.0448
Echinococcus granulosus Protein patched homolog 1 0.0096 0.0305 0.0346
Leishmania major acetyl-CoA synthetase, putative 0.0039 0.0076 0.162
Loa Loa (eye worm) hypothetical protein 0.0131 0.0446 0.0443
Brugia malayi Pyruvate kinase, muscle isozyme 0.0039 0.0076 0.0073
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0126 0.0426 0.0423
Loa Loa (eye worm) hypothetical protein 0.0096 0.0305 0.0302
Entamoeba histolytica pyruvate kinase, putative 0.0027 0.0029 0.0312
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0007 0.0003
Echinococcus multilocularis protein dispatched 1 0.0109 0.0359 0.0408
Brugia malayi Pax transcription activation domain interacting protein 0.0022 0.0008 0.0005
Onchocerca volvulus Huntingtin homolog 0.0126 0.0426 0.9432
Schistosoma mansoni hypothetical protein 0.0035 0.0061 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0008 0.0105
Plasmodium vivax replication factor C subunit 1, putative 0.0022 0.0008 0.018
Plasmodium vivax acyl-CoA synthetase, putative 0.0099 0.0317 0.7103
Mycobacterium ulcerans acyl-CoA synthetase 0.0039 0.0076 0.162
Echinococcus granulosus Niemann Pick C1 protein 0.0319 0.1202 0.1364
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0003 0.0004
Entamoeba histolytica hypothetical protein 0.0036 0.0064 0.0749
Loa Loa (eye worm) hypothetical protein 0.0131 0.0446 0.0443
Giardia lamblia DINP protein human, muc B family 0.0021 0.0006 0.0732
Entamoeba histolytica hypothetical protein 0.0131 0.0446 0.544
Brugia malayi Ets-domain containing protein 0.0072 0.0211 0.0208
Echinococcus granulosus GA binding protein alpha chain 0.0072 0.0211 0.024
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0526 0.2035 0.2032
Trypanosoma brucei DNA polymerase eta, putative 0.0049 0.0119 0.2602
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0022 0.0008 0.0103
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0007 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0007 0.0003
Leishmania major DNA polymerase kappa, putative 0.0021 0.0006 0.0049
Loa Loa (eye worm) ICD-1 protein 0.0036 0.0064 0.0061
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0131 0.0446 1
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0039 0.0076 0.162
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0039 0.0076 0.162
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0006 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0007 0.0003
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0007 0.0007
Echinococcus multilocularis nibrin 0.0022 0.0008 0.0009
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0007 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0007 0.0003
Plasmodium vivax acetyl-CoA synthetase, putative 0.0039 0.0076 0.1701
Echinococcus multilocularis GA binding protein alpha chain 0.0072 0.0211 0.024
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0039 0.0076 0.0073
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0007 0.0003
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0039 0.0076 0.1638
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0007 0.0003

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.