Detailed information for compound 592948

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 462.499 | Formula: C28H22N4O3
  • H donors: 3 H acceptors: 3 LogP: 4.53 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cccc(c1)c1cccc(c1)c1nc2c([nH]1)cccc2)COc1ccccc1C(=O)N
  • InChi: 1S/C28H22N4O3/c29-27(34)22-11-1-4-14-25(22)35-17-26(33)30-21-10-6-8-19(16-21)18-7-5-9-20(15-18)28-31-23-12-2-3-13-24(23)32-28/h1-16H,17H2,(H2,29,34)(H,30,33)(H,31,32)
  • InChiKey: VFKJLJHJVDGIEL-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Niemann Pick C1 protein 0.0201 0.118 0.118
Loa Loa (eye worm) STAT protein 0.0129 0.0722 0.2303
Schistosoma mansoni transcription factor LCR-F1 0.015 0.0859 0.2739
Brugia malayi conserved hypotetical protein 0.0014 0.0002 0.0006
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.02 0.117 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0288 0.1724 0.1724
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.0048
Echinococcus multilocularis snurportin 1 0.0328 0.1979 0.1979
Echinococcus granulosus replication factor c subunit 1 0.0061 0.0297 0.0947
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0086 0.0455 0.0455
Brugia malayi hypothetical protein 0.0014 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0333
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0044 0.0222
Plasmodium vivax replication factor C subunit 1, putative 0.0061 0.0297 1
Schistosoma mansoni hypothetical protein 0.0082 0.0428 0.1366
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0044 0.0222
Brugia malayi Pax transcription activation domain interacting protein 0.0061 0.0297 0.0947
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0111 0.0355
Onchocerca volvulus 0.0031 0.0104 0.037
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.02 0.117 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0059 0.0279 0.0891
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0104 0.0333
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0031 0.0104 0.0333
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0101 0.0544 0.1737
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0044 0.0222
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0031 0.0104 0.0333
Onchocerca volvulus Glycogen phosphorylase homolog 0.0462 0.2824 1
Echinococcus multilocularis survival motor neuron protein 1 0.0467 0.2853 0.2853
Schistosoma mansoni importin beta-1 0.0031 0.0104 0.0333
Schistosoma mansoni tar DNA-binding protein 0.0127 0.071 0.2264
Brugia malayi Cation transporter family protein 0.0031 0.0104 0.0333
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.0048
Echinococcus multilocularis nibrin 0.0061 0.0297 0.0297
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0333
Brugia malayi nuclear receptor NHR-67 0.0014 0.0002 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0104 0.0333
Brugia malayi Latrophilin receptor protein 2 0.0082 0.0428 0.1366
Giardia lamblia Kinase, PLK 0.0097 0.0521 0.1689
Echinococcus multilocularis protein dispatched 1 0.0099 0.0532 0.0532
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0002 0.0002
Mycobacterium ulcerans hypothetical protein 0.0072 0.0365 0.3008
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0365 0.3008
Schistosoma mansoni nuclear receptor 0.0014 0.0002 0.0006
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0044 0.014
Toxoplasma gondii ATPase, AAA family protein 0.0061 0.0297 1
Entamoeba histolytica hypothetical protein 0.015 0.0859 0.3003
Trichomonas vaginalis spcc417.12 protein, putative 0.0086 0.0455 0.1557
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0111 0.0111
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0521 0.1792
Trypanosoma cruzi hypothetical protein, conserved 0.0061 0.0297 0.5298
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0002 0.0006
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0104 0.0331
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0031 0.0104 0.0104
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0061 0.0297 0.5298
Schistosoma mansoni survival motor neuron protein 0.0095 0.0511 0.1629
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0044 0.0222
Loa Loa (eye worm) hypothetical protein 0.0072 0.0365 0.1164
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0104 0.0333
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0006
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0086 0.0455 0.1453
Brugia malayi tailless protein 0.0014 0.0002 0.0006
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0072 0.0365 0.3008
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0017 0.0015 0.0048
Loa Loa (eye worm) acetylcholinesterase 1 0.0512 0.3135 1
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0104 0.0333
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0021 0.0044 0.0222
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0061 0.0297 0.8037
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0037 0.0141 0.0141
Echinococcus multilocularis acetylcholinesterase 0.0512 0.3135 0.3135
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0365 0.1164
Echinococcus granulosus Glycosyl transferase family 35 0.0462 0.2824 0.9009
Onchocerca volvulus 0.0031 0.0104 0.037
Loa Loa (eye worm) hypothetical protein 0.0032 0.0111 0.0355
Schistosoma mansoni ferritin 0.0017 0.0018 0.0059
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.0002 0.0002
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0333
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0521 1
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0521 0.1792
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0044 0.014
Echinococcus multilocularis neuropeptide s receptor 0.0463 0.2826 0.2826
Brugia malayi nuclear receptor RXR 0.0014 0.0002 0.0006
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0013 0.0013
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0365 0.6723
Schistosoma mansoni tar DNA-binding protein 0.0127 0.071 0.2264
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0333
Mycobacterium tuberculosis Carboxylesterase LipT 0.0086 0.0455 0.3793
Brugia malayi TAR-binding protein 0.0127 0.071 0.2264
Chlamydia trachomatis DNA ligase 0.0061 0.0297 0.0182
Plasmodium vivax importin-beta 2, putative 0.0031 0.0104 0.2387
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0279 0.4931
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0031 0.0104 0.0333
Loa Loa (eye worm) latrophilin receptor protein 2 0.0082 0.0428 0.1366
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0104 0.0333
Mycobacterium ulcerans carboxylesterase, LipT 0.0086 0.0455 0.3793
Onchocerca volvulus 0.0061 0.0297 0.1051
Loa Loa (eye worm) carboxylesterase 0.0086 0.0455 0.1453
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0053 0.0193
Echinococcus multilocularis neuropeptide receptor A26 0.0463 0.2826 0.2826
Loa Loa (eye worm) hypothetical protein 0.0061 0.0297 0.0947
Onchocerca volvulus 0.0031 0.0104 0.037
Entamoeba histolytica glycogen phosphorylase, putative 0.0462 0.2824 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0104 0.0333
Loa Loa (eye worm) hypothetical protein 0.0061 0.0297 0.0947
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0044 0.0222
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0111 0.0355
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0365 0.6723
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0031 0.0104 0.0333
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0002 0.0006
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0002 0.0006
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0104 0.0333
Brugia malayi RNA recognition motif domain containing protein 0.0127 0.071 0.2264
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0061 0.0297 0.0992
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0297 0.0992
Loa Loa (eye worm) hypothetical protein 0.0086 0.0455 0.1452
Onchocerca volvulus 0.0021 0.0044 0.0156
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0104 0.0333
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0021 0.0044 0.0222
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0041
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0053 0.0365
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0104 0.0333
Loa Loa (eye worm) hypothetical protein 0.0512 0.3135 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0086 0.0455 0.1453
Echinococcus multilocularis expressed protein 0.0017 0.0018 0.0018
Echinococcus granulosus mitogen activated protein kinase 0.0059 0.0279 0.0891
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0215 0.0699
Schistosoma mansoni apoferritin-2 0.0017 0.0018 0.0059
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0072 0.0365 0.1164
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0365 0.3008
Onchocerca volvulus 0.0086 0.0455 0.1612
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0162 0.0516
Echinococcus multilocularis BC026374 protein (S09 family) 0.0086 0.0455 0.0455
Loa Loa (eye worm) hypothetical protein 0.0086 0.0455 0.1453
Schistosoma mansoni ferritin light chain 0.0017 0.0018 0.0059
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0037 0.0141 0.0449
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0013 0.0041
Onchocerca volvulus 0.0101 0.0544 0.1928
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0059 0.0279 0.4931
Brugia malayi Niemann-Pick C1 protein precursor 0.0201 0.118 0.3763
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.0104 0.0333
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0521 0.1792
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0002 0.0006
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0097 0.0521 1
Echinococcus granulosus acetylcholinesterase 0.0512 0.3135 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0365 0.3008
Schistosoma mansoni glycogen phosphorylase 0.0462 0.2824 0.9009
Schistosoma mansoni hypothetical protein 0.0095 0.0511 0.1629
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0013 0.0041
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0044 0.0222
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0333
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.0048
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0333
Onchocerca volvulus 0.0021 0.0044 0.0156
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0215 0.0699
Schistosoma mansoni ferritin 0.0017 0.0018 0.0059
Treponema pallidum DNA ligase (lig) 0.0061 0.0297 1
Brugia malayi Carboxylesterase family protein 0.0512 0.3135 1
Echinococcus multilocularis glycine receptor subunit beta 0.0031 0.0104 0.0104
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0054 0.025 0.2011
Onchocerca volvulus 0.0017 0.0015 0.0053
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0013 0.0041
Loa Loa (eye worm) hypothetical protein 0.0177 0.1029 0.3281
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0031 0.0104 0.0333
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0333
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0365 0.1246
Trypanosoma cruzi FHA domain containing protein, putative 0.0061 0.0297 0.5298
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0104 0.0104
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0201 0.118 0.4146
Schistosoma mansoni ferritin 0.0017 0.0018 0.0059
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0104 0.0104
Brugia malayi hypothetical protein 0.0061 0.0297 0.0947
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0006
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0257 0.1531 0.4882
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0104 0.0369
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0104 0.0333
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0013 0.0041
Echinococcus granulosus glycine receptor subunit alpha 1 0.0031 0.0104 0.0333
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0044 0.0222
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0104 0.2387
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.015 0.0859 0.2739
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0104 0.0333
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0333
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0031 0.0104 0.0333
Brugia malayi MAP kinase sur-1 0.0059 0.0279 0.0891
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0104 0.0104
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0111 0.0355
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0021 0.0044 0.0222
Echinococcus multilocularis mitogen activated protein kinase 3 0.0059 0.0279 0.0279
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0031 0.0104 0.0333
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0044 0.014
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0104 0.0333
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0104 0.0333
Brugia malayi nuclear hormone receptor 0.0014 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.014
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0037 0.0141 0.0449
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0365 1
Schistosoma mansoni DNA ligase IV 0.0061 0.0297 0.0947
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0044 0.014
Plasmodium vivax SET domain protein, putative 0.0032 0.0111 0.2658
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0044 0.014
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.0104 0.0333
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0232 0.185
Trypanosoma cruzi hypothetical protein, conserved 0.0061 0.0297 0.5298
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0021 0.0044 0.0738
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0053 0.0193
Schistosoma mansoni coup transcription factor 0.0031 0.0104 0.0333
Onchocerca volvulus 0.0072 0.0365 0.1292
Brugia malayi Carboxylesterase family protein 0.0086 0.0455 0.1453
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0002 0.0006
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0002 0.0006
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0021 0.0044 0.0222
Loa Loa (eye worm) DR-78 0.0014 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0333
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.0048
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0002 0.0007
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0059 0.0279 0.4931
Schistosoma mansoni ran 0.0023 0.0053 0.017
Echinococcus granulosus neuropeptide receptor A26 0.0463 0.2826 0.9015
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0044 0.0222
Schistosoma mansoni acetylcholinesterase 0.0086 0.0455 0.1453
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0044 0.0222
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.0044 0.0103
Brugia malayi nuclear receptor RXR 0.0016 0.0013 0.0041
Onchocerca volvulus 0.0086 0.0455 0.1612
Onchocerca volvulus 0.0086 0.0455 0.1612
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0104 0.0333
Echinococcus granulosus carboxylesterase 5A 0.0512 0.3135 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0104 0.0333
Entamoeba histolytica glycogen phosphorylase, putative 0.0462 0.2824 1
Entamoeba histolytica hypothetical protein 0.015 0.0859 0.3003
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.026 0.1546 0.4932
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0044 0.0222
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0279 0.093
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0127 0.071 0.2264
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0031 0.0104 0.0104
Onchocerca volvulus 0.0014 0.0002 0.0007
Brugia malayi nuclear hormone receptor 0.0031 0.0104 0.0333
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0333
Echinococcus granulosus ferritin 0.0017 0.0018 0.0059
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.0002 0.0006
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.0365 0.3008
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0017 0.0015 0.0048
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0097 0.0521 0.1663
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0061 0.0297 0.0947
Echinococcus multilocularis para nitrobenzyl esterase 0.0086 0.0455 0.0455
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0017 0.0015 0.0048
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0053 0.0365
Schistosoma mansoni nAChR subunit 0.0031 0.0104 0.0333
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0002 0.0006
Brugia malayi hypothetical protein 0.0014 0.0002 0.0006
Echinococcus granulosus tar DNA binding protein 0.0127 0.071 0.2264
Trypanosoma brucei protein kinase, putative 0.0059 0.0279 0.4931
Brugia malayi ecdysteroid receptor 0.0031 0.0104 0.0333
Brugia malayi nuclear receptor NHR-88 0.0031 0.0104 0.0333
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0021 0.0044 0.0222
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.014
Plasmodium falciparum importin beta, putative 0.0031 0.0104 0.2387
Echinococcus granulosus sterol regulatory element binding protein 0.0086 0.0455 0.1452
Schistosoma mansoni kinase 0.005 0.0223 0.071
Schistosoma mansoni topbp1 0.0061 0.0297 0.0947
Schistosoma mansoni hypothetical protein 0.015 0.0859 0.2739
Loa Loa (eye worm) pigment dispersing factor receptor c 0.026 0.1546 0.4932
Schistosoma mansoni nAChR subunit 0.0031 0.0104 0.0333
Loa Loa (eye worm) LGC-31 protein 0.0031 0.0104 0.0333
Leishmania major GTP-binding protein, putative 0.0023 0.0053 0.0193
Loa Loa (eye worm) hypothetical protein 0.0086 0.0455 0.1453
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0031 0.0104 0.0333
Schistosoma mansoni neuroligin 3 (S09 family) 0.0086 0.0455 0.1453
Onchocerca volvulus 0.0101 0.0544 0.1928
Schistosoma mansoni zinc finger protein 0.0014 0.0002 0.0006
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0104 0.0333
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0031 0.0104 0.0333
Plasmodium vivax acyl-CoA synthetase, putative 0.0054 0.025 0.8148
Brugia malayi serine/threonine-protein kinase plk-2 0.0097 0.0521 0.1663
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0104 0.0333
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0365 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0097 0.0521 0.1663
Echinococcus granulosus neuroligin 0.0086 0.0455 0.1453
Schistosoma mansoni patched 1 0.0086 0.0455 0.1452
Loa Loa (eye worm) hypothetical protein 0.0054 0.025 0.0798
Schistosoma mansoni BC026374 protein (S09 family) 0.0086 0.0455 0.1453
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0053 0.0193
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0333
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0031 0.0104 0.0333
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0031 0.0104 0.0333
Brugia malayi CHE-14 protein 0.0086 0.0455 0.1452
Leishmania major importin beta-1 subunit, putative 0.0025 0.0068 0.0497
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0104 0.0104
Brugia malayi hypothetical protein 0.0061 0.0297 0.0947
Echinococcus multilocularis protein patched 0.0086 0.0455 0.0455
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0104 0.0333
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0097 0.0521 0.0521
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0053 0.0053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0104 0.0333
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0044 0.0091
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0021 0.0044 0.0222
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0333
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0333
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0125 0.0381
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0333
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0044 0.0222
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0002 0.0006
Echinococcus granulosus Niemann Pick C1 protein 0.0201 0.118 0.3763
Brugia malayi Carboxylesterase family protein 0.0512 0.3135 1
Echinococcus granulosus geminin 0.0168 0.097 0.3095
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0104 0.0333
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0061 0.0297 0.2417
Entamoeba histolytica serine/threonine protein kinase, putative 0.0097 0.0521 0.1802
Echinococcus granulosus nibrin 0.0061 0.0297 0.0947
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0328 0.1979 0.6313
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0044 0.014
Echinococcus granulosus expressed protein 0.0017 0.0018 0.0059
Schistosoma mansoni tar DNA-binding protein 0.0127 0.071 0.2264
Plasmodium falciparum acyl-CoA synthetase 0.0054 0.025 0.8148
Brugia malayi carbohydrate phosphorylase 0.0462 0.2824 0.9009
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0111 0.2658
Echinococcus granulosus GPCR family 2 0.0082 0.0428 0.1366
Schistosoma mansoni ran 0.0023 0.0053 0.017
Brugia malayi steroid hormone receptor 0.0031 0.0104 0.0333
Brugia malayi Pre-SET motif family protein 0.0032 0.0111 0.0355
Loa Loa (eye worm) GABA receptor subunit 0.0017 0.0015 0.0048
Brugia malayi hypothetical protein 0.0016 0.0013 0.0041
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0086 0.0455 0.1453
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0333
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0162 0.0516
Onchocerca volvulus 0.0032 0.0111 0.0394
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0044 0.0222
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0044 0.0222
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0104 0.0333
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0333
Schistosoma mansoni apoferritin-2 0.0017 0.0018 0.0059
Echinococcus multilocularis glycogen phosphorylase 0.0462 0.2824 0.2824
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0333
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0002 0.0006
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0002 0.0006
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0061 0.0297 0.5298
Schistosoma mansoni topbp1 0.0061 0.0297 0.0947
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0059 0.0279 0.4931
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0104 0.0333
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0006
Schistosoma mansoni hypothetical protein 0.0083 0.0436 0.1389
Echinococcus granulosus glycine receptor subunit alpha 1 0.0031 0.0104 0.0333
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0333
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0061 0.0297 0.0992
Schistosoma mansoni tar DNA-binding protein 0.0127 0.071 0.2264
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0041
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0044 0.0222
Schistosoma mansoni chromosome transmission fidelity factor 0.0061 0.0297 0.0947
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0031 0.0104 0.0333
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0059 0.0279 0.4931
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0297 0.0992
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.0002 0.0006
Brugia malayi Calcitonin receptor-like protein seb-1 0.026 0.1546 0.4932
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0031 0.0104 0.0333
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0061 0.0297 1
Schistosoma mansoni hypothetical protein 0.0082 0.0428 0.1366
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0006
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.1031 0.3608
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0006
Schistosoma mansoni hypothetical protein 0.0328 0.1979 0.6313
Trichomonas vaginalis ran, putative 0.0023 0.0053 0.0124
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.1531 0.5389
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0018 0.0025 0.0061
Schistosoma mansoni hypothetical protein 0.0168 0.097 0.3095
Schistosoma mansoni hypothetical protein 0.0083 0.0436 0.1389
Echinococcus granulosus importin subunit beta 1 0.0031 0.0104 0.0333
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0279 0.093
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0086 0.0455 0.3793
Echinococcus granulosus glycogen phosphorylase 0.0462 0.2824 0.9009
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0002 0.0007
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0068 0.0176
Plasmodium falciparum replication factor C subunit 1, putative 0.0061 0.0297 1
Brugia malayi hypothetical protein 0.015 0.0859 0.2739
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0365 0.1164
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.0104 0.0333
Schistosoma mansoni hypothetical protein 0.0177 0.1029 0.3281
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0072 0.0365 0.3008
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0044 0.0044
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0101 0.0544 0.1737
Loa Loa (eye worm) hypothetical protein 0.0061 0.0297 0.0947
Brugia malayi Cation transporter family protein 0.0031 0.0104 0.0333
Loa Loa (eye worm) hypothetical protein 0.0072 0.0365 0.1164
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0031 0.0104 0.0333
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0002 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.1531 0.5389
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0021 0.0044 0.0738
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0031 0.0104 0.0333
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0104 0.1265
Entamoeba histolytica glycogen phosphorylase, putative 0.02 0.117 0.4113
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0104 0.0104
Echinococcus multilocularis sterol regulatory element binding protein 0.0086 0.0455 0.0455
Echinococcus multilocularis tar DNA binding protein 0.0127 0.071 0.071
Echinococcus granulosus snurportin 1 0.0328 0.1979 0.6313
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0086 0.0455 0.3793
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0031 0.0104 0.0333
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0297 0.0992
Onchocerca volvulus 0.0029 0.0092 0.0326
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0104 0.0369
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0044 0.014
Loa Loa (eye worm) ACC-1 protein 0.0031 0.0104 0.0333
Echinococcus granulosus nAChR subunit 0.0031 0.0104 0.0333
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0125 0.0381
Loa Loa (eye worm) hypothetical protein 0.0086 0.0455 0.1453
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0031 0.0104 0.0104
Loa Loa (eye worm) ACC-1 protein 0.0031 0.0104 0.0333
Onchocerca volvulus 0.0095 0.0511 0.1808
Trypanosoma brucei polo-like protein kinase 0.0097 0.0521 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0044 0.0222
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0104 0.0333
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0061 0.0297 0.0992
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0297 0.0992
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0455 0.1557
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.0104 0.0333
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0104 0.0333
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0104 0.0333
Brugia malayi Carboxylesterase family protein 0.0086 0.0455 0.1453
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0006
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.1031 0.3608
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0044 0.0091
Onchocerca volvulus Glucosylceramidase homolog 0.0169 0.0973 0.3447
Loa Loa (eye worm) oxidoreductase 0.0021 0.0044 0.014
Echinococcus multilocularis ferritin 0.0017 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.0048
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0031 0.0104 0.0333
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0973 0.3404
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0068 0.0497
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0053 0.0365
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.0104 0.0333
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.1531 0.5389
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0104 0.0333
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0279 0.093
Schistosoma mansoni hypothetical protein 0.0082 0.0428 0.1366
Onchocerca volvulus Putative nachr subunit 0.0031 0.0104 0.037
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0333
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0095 0.0511 0.1629
Onchocerca volvulus 0.0086 0.0455 0.1612
Onchocerca volvulus 0.0017 0.0015 0.0053
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0072 0.0365 0.3008
Entamoeba histolytica glycogenphosphorylase, putative 0.02 0.117 0.4113
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0232 0.185
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0041
Echinococcus granulosus mitogen activated protein kinase 3 0.0059 0.0279 0.0891
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.0002 0.0002
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0365 0.6723
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0002 0.0006
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0104 0.0104
Brugia malayi nuclear receptor NHR-88 0.0014 0.0002 0.0006
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0104 0.0333
Echinococcus granulosus glycine receptor subunit alpha 1 0.0031 0.0104 0.0333
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0521 1
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0017 0.0015 0.0048
Echinococcus granulosus expressed conserved protein 0.0189 0.1103 0.3517
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0104 0.0369
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0257 0.1531 0.4882
Loa Loa (eye worm) carboxylesterase 0.0512 0.3135 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0013 0.0041
Schistosoma mansoni hypothetical protein 0.0168 0.097 0.3095
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0973 0.3404
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0082 0.0428 0.0428
Echinococcus multilocularis glycogen phosphorylase 0.0462 0.2824 0.2824
Echinococcus multilocularis replication factor c subunit 1 0.0061 0.0297 0.0297
Schistosoma mansoni nAChR subunit 0.0031 0.0104 0.0333
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0104 0.0333
Loa Loa (eye worm) hypothetical protein 0.0512 0.3135 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0104 0.0333
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0973 0.3404
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0031 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.026 0.1546 0.4932
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.015 0.0859 0.0859
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0222 0.1309 0.4176
Loa Loa (eye worm) hypothetical protein 0.0086 0.0455 0.1453
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0061 0.0297 0.0992
Brugia malayi excitatory GABA receptor EXP-1A 0.0031 0.0104 0.0333
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0082 0.0428 0.1366
Brugia malayi RNA binding protein 0.0127 0.071 0.2264
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0104 0.1265
Schistosoma mansoni gliotactin 0.0086 0.0455 0.1453
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0104 0.0333
Echinococcus granulosus survival motor neuron protein 1 0.0467 0.2853 0.91
Loa Loa (eye worm) hypothetical protein 0.0201 0.118 0.3763
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0521 0.1663
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0104 0.0333
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0082 0.0428 0.0428
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0279 0.093
Entamoeba histolytica hypothetical protein 0.015 0.0859 0.3003
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0521 0.1792
Trichomonas vaginalis replication factor C large subunit, putative 0.0061 0.0297 0.0992
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0044 0.0222
Trichomonas vaginalis set domain proteins, putative 0.0253 0.1502 0.5289
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0333
Entamoeba histolytica Ran family GTPase 0.0023 0.0053 0.0136
Echinococcus multilocularis carboxylesterase 5A 0.0512 0.3135 0.3135
Entamoeba histolytica acyl-coA synthetase, putative 0.0072 0.0365 0.1246
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0333
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0053 0.017
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0072 0.0365 0.3008
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0061 0.0297 0.1003
Schistosoma mansoni ferritin 0.0017 0.0018 0.0059
Giardia lamblia Glycogen phosphorylase 0.0462 0.2824 1
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0031 0.0104 0.0333
Brugia malayi Pre-SET motif family protein 0.0222 0.1309 0.4176
Brugia malayi RNA, U transporter 1 0.0087 0.0462 0.1473
Loa Loa (eye worm) hypothetical protein 0.0086 0.0455 0.1453
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0104 0.0333
Echinococcus multilocularis nAChR subunit 0.0017 0.0015 0.0015
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0068 0.0176
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0017 0.0015 0.0048
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0002 0.0006
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0082 0.0428 0.1366
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0044 0.0222
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0044 0.0222
Loa Loa (eye worm) hypothetical protein 0.0032 0.011 0.0352
Entamoeba histolytica hypothetical protein 0.015 0.0859 0.3003
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.1531 0.5389
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0044 0.014
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0232 0.185
Schistosoma mansoni nAChR subunit 0.0031 0.0104 0.0333
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0031 0.0104 0.0104
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.0104 0.0333
Loa Loa (eye worm) TAR-binding protein 0.0127 0.071 0.2264
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0521 0.1792
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0006
Echinococcus multilocularis mitogen activated protein kinase 0.0059 0.0279 0.0279
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0082 0.0428 0.1366
Brugia malayi hypothetical protein 0.0467 0.2853 0.91
Brugia malayi Carboxylesterase family protein 0.0086 0.0455 0.1453
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0031 0.0104 0.0333
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0365 0.1246
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0973 0.3404
Echinococcus multilocularis expressed conserved protein 0.0189 0.1103 0.1103
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0053 0.017
Onchocerca volvulus 0.0021 0.0044 0.0156
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0013 0.0041
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0086 0.0455 0.1557
Schistosoma mansoni hypothetical protein 0.0083 0.0436 0.1389
Onchocerca volvulus Serine\/threonine kinase homolog 0.0097 0.0521 0.1846
Echinococcus granulosus Protein patched homolog 1 0.0086 0.0455 0.1452
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0333
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0006
Schistosoma mansoni hypothetical protein 0.0083 0.0436 0.1389
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0104 0.0333
Onchocerca volvulus 0.0101 0.0544 0.1928
Loa Loa (eye worm) glycogen phosphorylase 0.0462 0.2824 0.9009
Echinococcus granulosus glycogen phosphorylase 0.0462 0.2824 0.9009
Echinococcus multilocularis nAChR subunit 0.0031 0.0104 0.0104
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0031 0.0104 0.0104
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.0002 0.0006
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0072 0.0365 0.3008
Echinococcus multilocularis geminin 0.0168 0.097 0.097
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0031 0.0104 0.0104
Echinococcus multilocularis Glycosyl transferase, family 35 0.0462 0.2824 0.2824
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0006
Entamoeba histolytica glycogen phosphorylase, putative 0.02 0.117 0.4113
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0279 0.0891
Onchocerca volvulus 0.0253 0.1502 0.532
Schistosoma mansoni neurotransmitter gated ion channel 0.0017 0.0015 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0104 0.0333
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0031 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.0048
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.0048
Loa Loa (eye worm) hypothetical protein 0.0101 0.0544 0.1737
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0365 0.1164
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.1531 0.5389
Loa Loa (eye worm) carboxylesterase 0.0086 0.0455 0.1453
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0111 0.0355
Schistosoma mansoni nAChR subunit 0.0031 0.0104 0.0333
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0297 0.0992
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0104 0.0333
Brugia malayi Importin beta-1 subunit 0.0031 0.0104 0.0333
Onchocerca volvulus 0.0031 0.0104 0.0369
Echinococcus granulosus nAChR subunit 0.0017 0.0015 0.0048
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0104 0.0333
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0521 0.1792
Giardia lamblia Replication factor C, subunit 1 0.0061 0.0297 0.0879
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0031 0.0104 0.0333
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0006
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0054 0.025 0.0798
Echinococcus granulosus acetylcholinesterase 0.0512 0.3135 1
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0044 0.0222
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0053 0.017
Loa Loa (eye worm) hypothetical protein 0.0061 0.0297 0.0947
Schistosoma mansoni glycogen phosphorylase 0.0462 0.2824 0.9009
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0106 0.0578 0.1843
Loa Loa (eye worm) hypothetical protein 0.0086 0.0455 0.1453
Echinococcus granulosus neuropeptide s receptor 0.0463 0.2826 0.9015
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0104 0.0333
Loa Loa (eye worm) hypothetical protein 0.0054 0.025 0.0798
Loa Loa (eye worm) hypothetical protein 0.0467 0.2853 0.91
Brugia malayi Cation transporter family protein 0.0101 0.0544 0.1737
Echinococcus multilocularis GPCR, family 2 0.0082 0.0428 0.0428
Chlamydia trachomatis glycogen phosphorylase 0.0462 0.2824 1
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0031 0.0104 0.0333
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0082 0.0428 0.1366
Schistosoma mansoni ferritin light chain 0.0017 0.0018 0.0059
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0104 0.0104
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0061 0.0297 1
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0973 0.3404
Echinococcus granulosus BC026374 protein S09 family 0.0086 0.0455 0.1453
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0031 0.0104 0.0333
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0086 0.0455 0.1453
Entamoeba histolytica hypothetical protein 0.0025 0.0068 0.0188
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0044 0.014
Trichomonas vaginalis glycogen phosphorylase, putative 0.0462 0.2824 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0297 0.0947
Schistosoma mansoni nAChR subunit 0.0031 0.0104 0.0333
Giardia lamblia Kinase, CMGC MAPK 0.0059 0.0279 0.0816
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0205 0.1199 0.3826
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0031 0.0104 0.0333
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0086 0.0455 0.1452
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0973 0.3404
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.0002 0.0002
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0054 0.025 0.2011
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0333
Loa Loa (eye worm) hypothetical protein 0.0054 0.025 0.0798
Brugia malayi hypothetical protein 0.0016 0.0013 0.0041
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0104 0.0104
Echinococcus granulosus glycine receptor subunit beta 0.0031 0.0104 0.0333
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0031 0.0104 0.0104
Echinococcus multilocularis glycine receptor subunit beta 0.0031 0.0104 0.0104
Mycobacterium ulcerans acetyl-CoA synthetase 0.0021 0.0044 0.0222
Loa Loa (eye worm) hypothetical protein 0.0086 0.0455 0.1452
Echinococcus multilocularis acetylcholinesterase 0.0512 0.3135 0.3135
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0111 0.0355
Brugia malayi latrophilin 2 splice variant baaae 0.0177 0.1029 0.3281
Schistosoma mansoni tar DNA-binding protein 0.0127 0.071 0.2264
Brugia malayi DKFZp564C0469 protein 0.0061 0.0297 0.0947
Loa Loa (eye worm) hypothetical protein 0.0101 0.0544 0.1737
Schistosoma mansoni nuclear receptor 0.0014 0.0002 0.0006
Echinococcus granulosus glycine receptor subunit beta 0.0031 0.0104 0.0333
Onchocerca volvulus 0.0086 0.0455 0.1612
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0002 0.0006
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0031 0.0104 0.0333
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0044 0.014
Loa Loa (eye worm) hypothetical protein 0.0086 0.0455 0.1453
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0973 0.3404
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0021 0.0044 0.0222
Schistosoma mansoni hypothetical protein 0.0082 0.0428 0.1366
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0104 0.0333
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0333
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0031 0.0104 0.0104
Trichomonas vaginalis glycogen phosphorylase, putative 0.0462 0.2824 1
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0021 0.0044 0.0738
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.1531 0.5389
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0104 0.0333
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0104 0.0333
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0059 0.0279 0.4931
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0104 0.0333
Entamoeba histolytica hypothetical protein 0.0061 0.0297 0.1003
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0333
Brugia malayi ecdysone receptor 0.0014 0.0002 0.0006
Echinococcus granulosus para nitrobenzyl esterase 0.0086 0.0455 0.1453
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0031 0.0104 0.0333
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0512 0.3135 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0041
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0031 0.0104 0.0333
Schistosoma mansoni nAChR subunit 0.0031 0.0104 0.0333
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0017 0.0015 0.0048
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0037 0.0141 0.0449
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0104 0.0104
Brugia malayi STAT protein, DNA binding domain containing protein 0.0129 0.0722 0.2303
Loa Loa (eye worm) hypothetical protein 0.0054 0.025 0.0798
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0333
Brugia malayi topoisomerase 0.0061 0.0297 0.0947
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0104 0.0333
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0104 0.0104
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0068 0.0176
Brugia malayi Carboxylesterase family protein 0.0086 0.0455 0.1453
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.0048
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0104 0.0333
Echinococcus multilocularis neuroligin 0.0086 0.0455 0.0455
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0002 0.0006
Schistosoma mansoni glycogen phosphorylase 0.02 0.117 0.3733
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0031 0.0104 0.0333
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0031 0.0104 0.0333
Loa Loa (eye worm) RNA binding protein 0.0127 0.071 0.2264
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0279 0.4931
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0104 0.0333
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0232 0.185
Onchocerca volvulus 0.0014 0.0002 0.0007
Echinococcus granulosus Niemann Pick C1 protein 0.0288 0.1724 0.55
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0521 0.1792
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0044 0.0222
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0059 0.0279 0.9306
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0104 0.0333
Loa Loa (eye worm) hypothetical protein 0.0061 0.0297 0.0947
Brugia malayi hypothetical protein 0.0086 0.0455 0.1453

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = -4.32 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 0.34 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 1.07 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 3 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 23 % GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. ChEMBL. 20485427
Inhibition (functional) = 46 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 88 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition frequency index (IFI) (functional) = 8.55 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = 3 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 23 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = 46 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 88 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
XC50 (functional) = 6.42 XC50 determination of P. falciparum 3D7 growth GSK. 20485427
XC50 (functional) = 0.3764 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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