Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.014 | 0.1752 | 0.1752 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.0682 | 0.1472 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0107 | 0.1277 | 0.276 |
Trypanosoma brucei | metacaspase 5, putative | 0.0048 | 0.0421 | 0.1325 |
Giardia lamblia | 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase | 0.0029 | 0.0142 | 0.0811 |
Plasmodium vivax | purine nucleoside phosphorylase, putative | 0.0029 | 0.0142 | 0.0267 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.0682 | 0.0682 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0056 | 0.0536 | 0.0536 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.004 | 0.0306 | 0.1749 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0111 | 0.1331 | 0.1331 |
Trypanosoma brucei | metacaspase MCA3 | 0.0048 | 0.0421 | 0.1325 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0058 | 0.0568 | 0.0568 |
Trypanosoma cruzi | metacaspase, putative | 0.0048 | 0.0421 | 0.1325 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.0029 | 0.0142 | 0.0142 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0056 | 0.0536 | 0.1688 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0029 | 0.0142 | 0.0811 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0029 | 0.0142 | 0.2647 |
Trichomonas vaginalis | conserved hypothetical protein | 0.004 | 0.0306 | 0.1749 |
Trypanosoma cruzi | oligopeptidase b | 0.0056 | 0.0536 | 0.1688 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0029 | 0.0142 | 0.0811 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0056 | 0.0536 | 0.017 |
Echinococcus granulosus | caspase | 0.0127 | 0.1571 | 0.1571 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0238 | 0.3177 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0048 | 0.0421 | 0.2404 |
Trypanosoma cruzi | metacaspase, putative | 0.0048 | 0.0421 | 0.1325 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0338 | 0.4629 | 1 |
Brugia malayi | Cell death protein 3 precursor | 0.0093 | 0.1072 | 0.1072 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0238 | 0.3177 | 1 |
Echinococcus granulosus | caspase 2 | 0.0093 | 0.1072 | 0.1072 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.014 | 0.1752 | 1 |
Trypanosoma brucei | metacaspase MCA2 | 0.0048 | 0.0421 | 0.1325 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0107 | 0.1277 | 0.276 |
Brugia malayi | mucosa associated lymphoid tissue lymphoma translocation protein 1 | 0.0048 | 0.0421 | 0.0421 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0119 | 0.1451 | 0.8133 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.004 | 0.0306 | 0.0306 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0029 | 0.0142 | 0.0811 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0056 | 0.0536 | 0.0536 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0048 | 0.0421 | 0.2404 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0029 | 0.0142 | 0.0811 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.014 | 0.1752 | 0.1752 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0029 | 0.0142 | 0.0307 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.0019 | 0.0108 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.0127 | 0.1571 | 0.1571 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0048 | 0.0421 | 0.1273 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0029 | 0.0142 | 0.2647 |
Mycobacterium ulcerans | bifunctional Mta/Sah nucleosidase Mtn | 0.0029 | 0.0142 | 0.0307 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0.0019 | 0.006 |
Schistosoma mansoni | uridine phosphorylase | 0.0029 | 0.0142 | 0.0142 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.0682 | 0.1472 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.0421 | 0.2404 |
Toxoplasma gondii | Purine nucleoside phosphorylase | 0.0029 | 0.0142 | 0.0389 |
Brugia malayi | purine nucleoside phosphorylase I, inosine and guanosine-specific family protein | 0.014 | 0.1752 | 0.1752 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0238 | 0.3177 | 1 |
Echinococcus multilocularis | uridine phosphorylase 1 | 0.0029 | 0.0142 | 0.0142 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0066 | 0.0682 | 0.0682 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0338 | 0.4629 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0044 | 0.0359 | 0.6694 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.014 | 0.1752 | 0.1752 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0111 | 0.1331 | 0.1331 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0056 | 0.0536 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0044 | 0.0359 | 0.6694 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0056 | 0.0536 | 0.0536 |
Giardia lamblia | UPL-1 | 0.0029 | 0.0142 | 0.0811 |
Trypanosoma brucei | methylthioadenosine phosphorylase, putative | 0.0029 | 0.0142 | 0.0447 |
Chlamydia trachomatis | oxoacyl-ACP synthase III | 0.0338 | 0.4629 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0048 | 0.0421 | 0.2404 |
Brugia malayi | uridine phosphorylase family protein | 0.0029 | 0.0142 | 0.0142 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.0029 | 0.0142 | 0.0447 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0029 | 0.0142 | 0.0811 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0029 | 0.0142 | 0.2647 |
Mycobacterium ulcerans | purine nucleoside phosphorylase | 0.014 | 0.1752 | 0.3784 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.0029 | 0.0142 | 0.0142 |
Toxoplasma gondii | acylaminoacyl-peptidase, putative | 0.0056 | 0.0536 | 0.1638 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0062 | 0.0629 | 0.0629 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0045 | 0.0373 | 0.0373 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.014 | 0.1752 | 0.1752 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0056 | 0.0536 | 0.3062 |
Trypanosoma brucei | uridine phosphorylase | 0.0029 | 0.0142 | 0.0447 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.004 | 0.0306 | 0.0306 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.0019 | 0.006 |
Leishmania major | nucleoside phosphorylase-like protein | 0.0029 | 0.0142 | 0.0447 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.004 | 0.0306 | 0.0964 |
Trypanosoma brucei | serine peptidase, clan SC, family S9A-like protein | 0.0056 | 0.0536 | 0.1688 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0056 | 0.0536 | 0.1688 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0338 | 0.4629 | 1 |
Echinococcus multilocularis | caspase | 0.0127 | 0.1571 | 0.1571 |
Leishmania major | oligopeptidase b | 0.0056 | 0.0536 | 0.1688 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.0421 | 0.2404 |
Echinococcus multilocularis | caspase 2 | 0.0093 | 0.1072 | 0.1072 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.014 | 0.1752 | 0.1752 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.0019 | 0.0354 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.1403 | 0.1403 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0019 | 0.006 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.004 | 0.0306 | 0.0306 |
Trypanosoma cruzi | metacaspase, putative | 0.0048 | 0.0421 | 0.1325 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0.0019 | 0.0041 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0047 | 0.0404 | 0.0404 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0019 | 0.006 |
Trypanosoma cruzi | serine peptidase, clan SC, family S9A-like protein, putative | 0.0056 | 0.0536 | 0.1688 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.1072 | 0.1072 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0238 | 0.3177 | 1 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0048 | 0.0421 | 0.1273 |
Echinococcus multilocularis | caspase 3 | 0.0079 | 0.0871 | 0.0871 |
Treponema pallidum | pfs protein (pfs) | 0.0029 | 0.0142 | 1 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0093 | 0.1072 | 0.1072 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0107 | 0.1277 | 0.276 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.014 | 0.1752 | 0.1752 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0062 | 0.0629 | 0.1358 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0107 | 0.1277 | 0.276 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.014 | 0.1752 | 0.1752 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0019 | 0.0108 |
Brugia malayi | MTAP | 0.0029 | 0.0142 | 0.0142 |
Entamoeba histolytica | hypothetical protein | 0.0029 | 0.0142 | 0.2647 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.004 | 0.0306 | 0.0306 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.004 | 0.0306 | 0.0306 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0421 | 0.0421 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0119 | 0.1451 | 0.3135 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.014 | 0.1752 | 0.1752 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.0019 | 0.0019 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0536 | 0.0536 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.014 | 0.1752 | 0.1752 |
Plasmodium vivax | metacaspase 1, putative | 0.0048 | 0.0421 | 0.0872 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0047 | 0.0404 | 0.127 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0056 | 0.0536 | 0.0536 |
Trypanosoma cruzi | oligopeptidase b | 0.0056 | 0.0536 | 0.1688 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.0682 | 0.1472 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0029 | 0.0142 | 0.0811 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.1403 | 0.1403 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0047 | 0.0404 | 0.0872 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.0029 | 0.0142 | 0.0447 |
Trypanosoma cruzi | metacaspase, putative | 0.0048 | 0.0421 | 0.1325 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0029 | 0.0142 | 0.0307 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0048 | 0.0421 | 0.2404 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0238 | 0.3177 | 1 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0056 | 0.0536 | 1 |
Treponema pallidum | purine nucleoside phosphorylase (deoD) | 0.0029 | 0.0142 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0708 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0019 | 0.0108 |
Echinococcus granulosus | uridine phosphorylase 1 | 0.0029 | 0.0142 | 0.0142 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0056 | 0.0536 | 0.1688 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.0029 | 0.0142 | 0.0447 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0119 | 0.1451 | 0.3135 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.004 | 0.0306 | 0.0306 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0056 | 0.0536 | 0.1159 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0019 | 0.0019 |
Brugia malayi | Thioredoxin reductase | 0.0047 | 0.0404 | 0.0404 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.004 | 0.0306 | 0.0964 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.0421 | 0.2404 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0066 | 0.0682 | 0.2145 |
Giardia lamblia | Purine nucleoside phosphorylase lateral transfer candidate | 0.014 | 0.1752 | 1 |
Leishmania major | methylthioadenosine phosphorylase, putative | 0.0029 | 0.0142 | 0.0447 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.0029 | 0.0142 | 0.0142 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0238 | 0.3177 | 0.3177 |
Brugia malayi | glutathione reductase | 0.0047 | 0.0404 | 0.0404 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0056 | 0.0536 | 0.245 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0047 | 0.0404 | 0.0404 |
Mycobacterium ulcerans | 5'-methylthioadenosine phosphorylase | 0.0029 | 0.0142 | 0.0307 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.0019 | 0.0019 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0056 | 0.0536 | 0.1688 |
Trypanosoma brucei | prolyl endopeptidase | 0.0056 | 0.0536 | 0.1688 |
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.0056 | 0.0536 | 0.1159 |
Onchocerca volvulus | Purine nucleoside phosphorylase homolog | 0.014 | 0.1752 | 0.1432 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0066 | 0.0682 | 0.1472 |
Trypanosoma brucei | prolyl oligopeptidase, putative | 0.0056 | 0.0536 | 0.1688 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.014 | 0.1752 | 0.1752 |
Echinococcus granulosus | caspase 3 apoptosis cysteine peptidase | 0.0127 | 0.1571 | 0.1571 |
Brugia malayi | hypothetical protein | 0.0182 | 0.2363 | 0.2363 |
Toxoplasma gondii | prolyl endopeptidase | 0.0056 | 0.0536 | 0.1638 |
Plasmodium falciparum | thioredoxin reductase | 0.0047 | 0.0404 | 0.0834 |
Schistosoma mansoni | uridine phosphorylase | 0.0029 | 0.0142 | 0.0142 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0019 | 0.0019 |
Mycobacterium tuberculosis | Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase | 0.0029 | 0.0142 | 0.0307 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0029 | 0.0142 | 0.2647 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0029 | 0.0142 | 0.0811 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0048 | 0.0421 | 0.2404 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.004 | 0.0306 | 0.1749 |
Plasmodium vivax | glutathione reductase, putative | 0.0047 | 0.0404 | 0.0834 |
Trypanosoma brucei | Metacaspase-4 | 0.0048 | 0.0421 | 0.1325 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0093 | 0.1072 | 0.0726 |
Echinococcus granulosus | caspase 8 | 0.0048 | 0.0421 | 0.0421 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0708 | 1 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.0019 | 0.0041 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.0056 | 0.0536 | 0.3062 |
Mycobacterium tuberculosis | Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) | 0.014 | 0.1752 | 0.3784 |
Echinococcus granulosus | inosine guanosine and xanthosine phosphorylase | 0.0111 | 0.1331 | 0.1331 |
Schistosoma mansoni | acylaminoacyl-peptidase (S09 family) | 0.0056 | 0.0536 | 0.0536 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.014 | 0.1752 | 0.1752 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0338 | 0.4629 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0047 | 0.0404 | 0.127 |
Trypanosoma cruzi | oligopeptidase B-like protein, putative | 0.0056 | 0.0536 | 0.1688 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0056 | 0.0536 | 0.0536 |
Toxoplasma gondii | thioredoxin reductase | 0.0047 | 0.0404 | 0.1218 |
Mycobacterium tuberculosis | Probable reductase | 0.0107 | 0.1277 | 0.276 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.0421 | 0.2404 |
Loa Loa (eye worm) | uridine phosphorylase | 0.0029 | 0.0142 | 0.0142 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0127 | 0.1571 | 0.1571 |
Echinococcus granulosus | caspase 3 | 0.0079 | 0.0871 | 0.0871 |
Echinococcus multilocularis | acylamino acid releasing enzyme | 0.0056 | 0.0536 | 0.0536 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0238 | 0.3177 | 1 |
Echinococcus granulosus | acylamino acid releasing enzyme | 0.0056 | 0.0536 | 0.0536 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.0421 | 0.2404 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0536 | 0.0536 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0029 | 0.0142 | 0.2647 |
Echinococcus granulosus | prolyl endopeptidase | 0.0056 | 0.0536 | 0.0536 |
Leishmania major | trypanothione reductase | 0.0047 | 0.0404 | 0.127 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.0127 | 0.1571 | 0.1571 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0056 | 0.0536 | 0.0536 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.014 | 0.1752 | 0.1752 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.0421 | 0.2404 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0056 | 0.0536 | 0.3062 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0107 | 0.1277 | 0.7054 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.014 | 0.1752 | 0.1752 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.0029 | 0.0142 | 0.0447 |
Toxoplasma gondii | phosphorylase family protein | 0.0029 | 0.0142 | 0.0389 |
Trichomonas vaginalis | purine nucleoside phosphorylase I, putative | 0.014 | 0.1752 | 1 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.004 | 0.0306 | 0.1749 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.004 | 0.0306 | 0.0306 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0066 | 0.0682 | 0.0682 |
Toxoplasma gondii | hypothetical protein | 0.0056 | 0.0536 | 0.1638 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0056 | 0.0536 | 0.0536 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0056 | 0.0536 | 1 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.004 | 0.0306 | 0.0964 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0306 | 0.0306 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0062 | 0.0629 | 0.0629 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0048 | 0.0421 | 0.2404 |
Echinococcus multilocularis | methylthioadenosine phosphorylase | 0.0029 | 0.0142 | 0.0142 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.014 | 0.1752 | 0.1752 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0048 | 0.0421 | 0.1325 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0045 | 0.0373 | 0.0373 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0056 | 0.0536 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0048 | 0.0421 | 0.2404 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0708 | 1 | 1 |
Leishmania major | metacaspase, putative | 0.0048 | 0.0421 | 0.1325 |
Echinococcus granulosus | methylthioadenosine phosphorylase | 0.0029 | 0.0142 | 0.0142 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.014 | 0.1752 | 0.1752 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.0019 | 0.0019 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.004 | 0.0306 | 0.0306 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0066 | 0.0682 | 0.2098 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.004 | 0.0306 | 0.0964 |
Toxoplasma gondii | phosphorylase family protein | 0.0029 | 0.0142 | 0.0389 |
Giardia lamblia | 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase | 0.0029 | 0.0142 | 0.0811 |
Trypanosoma brucei | metacaspase | 0.0048 | 0.0421 | 0.1325 |
Plasmodium falciparum | metacaspase-like protein | 0.0048 | 0.0421 | 0.0872 |
Plasmodium falciparum | purine nucleoside phosphorylase | 0.0029 | 0.0142 | 0.0267 |
Plasmodium falciparum | glutathione reductase | 0.0047 | 0.0404 | 0.0834 |
Loa Loa (eye worm) | S-methyl-5'-thioadenosine phosphorylase MTAP | 0.0029 | 0.0142 | 0.0142 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0062 | 0.0629 | 0.1358 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.014 | 0.1752 | 0.1752 |
Plasmodium falciparum | metacaspase 1 | 0.0048 | 0.0421 | 0.0872 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.0029 | 0.0142 | 0.0447 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0048 | 0.0421 | 0.2404 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0029 | 0.0142 | 0.0811 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.1403 | 0.1403 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0048 | 0.0421 | 0.2404 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0056 | 0.0536 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0056 | 0.0536 | 0.3062 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0536 | 0.0536 |
Plasmodium vivax | hypothetical protein, conserved | 0.0048 | 0.0421 | 0.0872 |
Echinococcus multilocularis | caspase 8 | 0.0048 | 0.0421 | 0.0421 |
Trypanosoma brucei | oligopeptidase b | 0.0056 | 0.0536 | 0.1688 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0238 | 0.3177 | 0.3177 |
Schistosoma mansoni | hypothetical protein | 0.0045 | 0.0373 | 0.0373 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0107 | 0.1277 | 0.276 |
Schistosoma mansoni | subfamily C14A unassigned peptidase (C14 family) | 0.0048 | 0.0421 | 0.0421 |
Entamoeba histolytica | MTA/SAH nucleosidase, putative | 0.0029 | 0.0142 | 0.2647 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0044 | 0.0359 | 0.6694 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.004 | 0.0306 | 0.0306 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0338 | 0.4629 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0044 | 0.0359 | 0.6694 |
Loa Loa (eye worm) | glutathione reductase | 0.0047 | 0.0404 | 0.0404 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0373 | 0.0373 |
Plasmodium falciparum | peptidase, putative | 0.0056 | 0.0536 | 0.1122 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.2363 | 0.2363 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0047 | 0.0404 | 0.0834 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0338 | 0.4629 | 1 |
Treponema pallidum | uridine phosphorylase (udp) | 0.0029 | 0.0142 | 1 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0238 | 0.3177 | 0.3177 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0048 | 0.0421 | 0.1273 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0708 | 1 | 1 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0062 | 0.0629 | 0.1978 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0056 | 0.0536 | 0.3062 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0062 | 0.0629 | 0.0629 |
Brugia malayi | hypothetical protein | 0.0045 | 0.0373 | 0.0373 |
Plasmodium vivax | hypothetical protein, conserved | 0.0056 | 0.0536 | 0.1122 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0044 | 0.0359 | 0.6694 |
Mycobacterium tuberculosis | Probable peptidase | 0.0056 | 0.0536 | 0.1159 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.004 | 0.0306 | 0.5711 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0048 | 0.0421 | 0.1325 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0062 | 0.0629 | 0.0629 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0056 | 0.0536 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0708 | 1 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0062 | 0.0629 | 0.1358 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0047 | 0.0404 | 0.0404 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0056 | 0.0536 | 0.0536 |
Leishmania major | oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein | 0.0056 | 0.0536 | 0.1688 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1331 | 0.1331 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.0682 | 0.0682 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0238 | 0.3177 | 0.3177 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0338 | 0.4629 | 1 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0029 | 0.0142 | 0.0811 |
Trypanosoma brucei | Alpha/beta hydrolase domain-containing protein | 0.0056 | 0.0536 | 0.1688 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.0019 | 0.0019 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0119 | 0.1451 | 0.3135 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 35 % | Inhibition of estradiol-induced uterine weight gain in ovariectomized BALB/c mice at 3 ug dose twice daily | ChEMBL. | 2033587 |
Inhibition (functional) | = 82 % | Inhibition of estradiol-induced uterine weight gain in ovariectomized BALB/c mice at 20 ug dose twice daily | ChEMBL. | 2033587 |
RBA (binding) | = 1.1 | Relative binding affinity for estrogen receptor from immature rat uterus | ChEMBL. | 2033587 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.