TDR Targets

Basic information

Technical information

TDR Targets ID: 618969
Name: N-[2-(4-chlorophenyl)-4,6-dihydrothieno[3,4-d ]pyrazol-3-yl]-3,4,5-triethoxybenzamide
MW: 487.999 | Formula: C24H26ClN3O4S
H donors: 1 H acceptors: 2 LogP: 4.76 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1cc(cc(c1OCC)OCC)C(=O)Nc1c2CSCc2nn1c1ccc(cc1)Cl
InChi: 1S/C24H26ClN3O4S/c1-4-30-20-11-15(12-21(31-5-2)22(20)32-6-3)24(29)26-23-18-13-33-14-19(18)27-28(23)17-9-7-16(25)8-10-17/h7-12H,4-6,13-14H2,1-3H3,(H,26,29)
InChiKey: YFXCHHCBAZTFPM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[2-(4-chlorophenyl)-4,6-dihydrothieno[3,4-d]pyrazol-3-yl]-3,4,5-triethoxy-benzamide
Oprea1_775209

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0019	0.0219	0.1103
Toxoplasma gondii	ornithine aminotransferase, mitochondrial precursor, putative	0.0022	0.03	0.0942
Brugia malayi	4-aminobutyrate aminotransferase, mitochondrial precursor	0.0022	0.03	0.0569
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0617	0.0811
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0219	0.1566
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0018	0.0209	0.0989
Onchocerca volvulus		0.0035	0.0617	0.2304
Echinococcus multilocularis	lamin	0.0028	0.0434	0.0434
Trypanosoma brucei	DNA polymerase eta, putative	0.0019	0.0219	0.1566
Trypanosoma brucei	PAB1-binding protein , putative	0.005	0.0987	1
Toxoplasma gondii	LsmAD domain-containing protein	0.005	0.0987	0.8032
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0227	0.5276	1
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0085	0.0085
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.0686	0.0686
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0018	0.0209	0.0989
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0617	0.1169
Brugia malayi	follicle stimulating hormone receptor	0.0227	0.5276	1
Schistosoma mansoni	ornithine--oxo-acid transaminase	0.0022	0.03	0.03
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0617	0.0811
Plasmodium falciparum	ornithine aminotransferase	0.0022	0.03	0.1173
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0209	0.0396
Leishmania major	hypothetical protein, conserved	0.0035	0.0617	0.571
Trypanosoma cruzi	PAB1-binding protein , putative	0.005	0.0987	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0073	0.0138
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0053	0.1044	0.1978
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0085	0.0161
Echinococcus granulosus	Aminotransferase class III	0.0022	0.03	0.03
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0219	0.1103
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0219	0.0219
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0219	0.1566
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0024	0.0337	0.0337
Echinococcus multilocularis	zinc finger protein	0.0021	0.0267	0.0267
Mycobacterium ulcerans	4-aminobutyrate aminotransferase	0.0022	0.03	0.0272
Brugia malayi	CXXC zinc finger family protein	0.003	0.0478	0.0907
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0434	0.0434
Chlamydia trachomatis	glutamate-1-semialdehyde-2,1-aminomutase	0.0022	0.03	0.5
Echinococcus granulosus	lamin dm0	0.0028	0.0434	0.0434
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0219	0.1566
Echinococcus multilocularis	cpg binding protein	0.0033	0.0565	0.0565
Mycobacterium ulcerans	adenosylmethionine-8-amino-7-oxononanoate aminotransferase	0.0156	0.3565	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0166	0.0166
Mycobacterium tuberculosis	Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase)	0.0022	0.03	0.0182
Schistosoma mansoni	ap endonuclease	0.0018	0.0209	0.0209
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0017	0.0181	0.0181
Loa Loa (eye worm)	hypothetical protein	0.004	0.073	0.1383
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0019	0.0219	0.0207
Toxoplasma gondii	ABC1 family protein	0.0035	0.0617	0.4208
Mycobacterium ulcerans	glutamate-1-semialdehyde aminotransferase	0.0022	0.03	0.0272
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0166	0.0166
Schistosoma mansoni	hypothetical protein	0.0421	1	1
Onchocerca volvulus		0.0035	0.0617	0.2304
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0617	0.1215
Echinococcus granulosus	dna polymerase eta	0.0019	0.0219	0.0219
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0166	0.0314
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0053	0.1044	0.1978
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0617	0.1169
Brugia malayi	Bromodomain containing protein	0.0075	0.1587	0.3007
Echinococcus multilocularis	musashi	0.0028	0.0434	0.0434
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0617	0.0811
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0141	0.3204	0.3204
Onchocerca volvulus		0.003	0.0478	0.1787
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0019	0.0219	0.002
Schistosoma mansoni	cpg binding protein	0.0033	0.0565	0.0565
Schistosoma mansoni	hypothetical protein	0.0038	0.0686	0.0686
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0209	0.1458
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.0637	0.1208
Echinococcus multilocularis	Aminotransferase class III	0.0022	0.03	0.03
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0017	0.0165	0.0165
Trypanosoma cruzi	DNA polymerase eta, putative	0.0019	0.0219	0.1103
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0219	0.1566
Brugia malayi	intermediate filament protein	0.0028	0.0434	0.0824
Loa Loa (eye worm)	hypothetical protein	0.005	0.0987	0.1871
Mycobacterium ulcerans	acetylornithine aminotransferase	0.0022	0.03	0.0272
Schistosoma mansoni	lamin	0.0028	0.0434	0.0434
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0219	0.1566
Mycobacterium tuberculosis	Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase)	0.0022	0.03	0.0182
Schistosoma mansoni	hypothetical protein	0.0017	0.0166	0.0166
Echinococcus multilocularis	dna polymerase eta	0.0019	0.0219	0.0219
Plasmodium falciparum	ataxin-2 like protein, putative	0.005	0.0987	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0617	0.1169
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0219	0.1566
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.0219	0.0219
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0219	0.0029
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0617	0.571
Onchocerca volvulus		0.0028	0.0434	0.1623
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0121	0.0229
Echinococcus multilocularis	ornithine aminotransferase	0.0022	0.03	0.03
Echinococcus granulosus	GPCR family 2	0.0017	0.0166	0.0166
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0617	0.0811
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0165	0.0165
Echinococcus granulosus	histone lysine methyltransferase setb	0.0017	0.0181	0.0181
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0023	0.031	0.031
Echinococcus granulosus	lamin	0.0028	0.0434	0.0434
Mycobacterium ulcerans	ornithine aminotransferase RocD1 and RocD2	0.0022	0.03	0.0272
Mycobacterium ulcerans	lipase LipD	0.0035	0.0617	0.1215
Loa Loa (eye worm)	hypothetical protein	0.0053	0.1044	0.1978
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0017	0.0181	0.0181
Brugia malayi	hypothetical protein	0.0038	0.0686	0.1301
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0673	0.1276
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0219	0.1103
Brugia malayi	PHD-finger family protein	0.0026	0.0394	0.0746
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0219	0.1566
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0617	0.5933
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0434	0.0824
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0617	0.0617
Trypanosoma cruzi	PAB1-binding protein , putative	0.005	0.0987	1
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0209	0.0209
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0166	0.0314
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0141	0.3204	0.3204
Brugia malayi	F/Y-rich N-terminus family protein	0.0011	0.0024	0.0046
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0166	0.0166
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0053	0.1044	0.1978
Onchocerca volvulus		0.0028	0.0434	0.1623
Entamoeba histolytica	hypothetical protein	0.0038	0.0686	1
Entamoeba histolytica	hypothetical protein	0.0038	0.0686	1
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0035	0.0615	0.0615
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0434	0.0824
Schistosoma mansoni	hypothetical protein	0.0023	0.031	0.031
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0617	0.0811
Trichomonas vaginalis	esterase, putative	0.0035	0.0617	0.1215
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0617	0.1215
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0219	0.0415
Loa Loa (eye worm)	PHD-finger family protein	0.002	0.0251	0.0475
Echinococcus granulosus	zinc finger protein	0.0021	0.0267	0.0267
Mycobacterium tuberculosis	Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at)	0.0022	0.03	0.0182
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0617	0.0969
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0617	0.1215
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0035	0.0615	0.0615
Echinococcus multilocularis	dnaJ subfamily B	0.0421	1	1
Onchocerca volvulus		0.0035	0.0617	0.2304
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0617	0.0617
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0617	0.0617
Mycobacterium leprae	PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA	0.0156	0.3565	1
Schistosoma mansoni	hypothetical protein	0.0015	0.0124	0.0124
Echinococcus granulosus	fetal alzheimer antigen falz	0.0024	0.0337	0.0337
Brugia malayi	beta-lactamase family protein	0.0035	0.0617	0.1169
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0219	0.1566
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0434	0.0824
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0141	0.3204	0.3204
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0617	0.1215
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0121	0.0229
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0617	0.0969
Echinococcus granulosus	ornithine aminotransferase	0.0022	0.03	0.03
Brugia malayi	hypothetical protein	0.005	0.0987	0.1871
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0166	0.0166
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0617	0.1215
Wolbachia endosymbiont of Brugia malayi	acetylornithine transaminase protein	0.0022	0.03	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0141	0.3204	0.6073
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.0686	0.0686
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0617	0.0811
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.006	0.1222	0.1222
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0165	0.0165
Onchocerca volvulus	Huntingtin homolog	0.012	0.2677	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0181	0.0343
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0019	0.0219	0.0029
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0058	0.1178	1
Mycobacterium tuberculosis	Probable acetylornithine aminotransferase ArgD	0.0022	0.03	0.0182
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0219	0.0219
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0225	0.5238	1
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0219	0.0219
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0209	0.0989
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0617	0.1215
Mycobacterium ulcerans	4-aminobutyrate aminotransferase	0.0022	0.03	0.0272
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0617	0.0811
Brugia malayi	hypothetical protein	0.012	0.2677	0.5075
Entamoeba histolytica	hypothetical protein	0.0038	0.0686	1
Schistosoma mansoni	hypothetical protein	0.0036	0.0637	0.0637
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0141	0.3204	0.3204
Schistosoma mansoni	hypothetical protein	0.002	0.0251	0.0251
Schistosoma mansoni	DNA polymerase eta	0.0019	0.0219	0.0219
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0617	0.0811
Schistosoma mansoni	bromodomain containing protein	0.0064	0.1307	0.1307
Mycobacterium tuberculosis	Probable aminotransferase	0.0156	0.3565	0.6674
Schistosoma mansoni	hypothetical protein	0.0017	0.0166	0.0166
Trichomonas vaginalis	acetylornithine aminotransferase, putative	0.0156	0.3565	1
Schistosoma mansoni	lamin	0.0028	0.0434	0.0434
Trypanosoma brucei	unspecified product	0.0019	0.0219	0.1566
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0166	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0073	0.0138
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0019	0.0219	0.002
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0617	0.0811
Entamoeba histolytica	hypothetical protein	0.0038	0.0686	1
Echinococcus granulosus	cpg binding protein	0.0033	0.0565	0.0565
Trichomonas vaginalis	DNA polymerase eta, putative	0.0019	0.0219	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0637	0.1208
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0219	0.1566
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0816	0.1547
Mycobacterium ulcerans	L-lysine aminotransferase	0.0022	0.03	0.0272
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1444	0.2737
Schistosoma mansoni	zinc finger protein	0.0015	0.0124	0.0124
Schistosoma mansoni	cpg binding protein	0.0033	0.0565	0.0565
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0219	0.0219
Leishmania major	hypothetical protein, conserved	0.005	0.0987	1
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.006	0.1222	0.1222
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0166	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0617	0.1169
Leishmania major	DNA polymerase eta, putative	0.0019	0.0219	0.1103
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0219	0.1566
Brugia malayi	Bromodomain containing protein	0.0037	0.0671	0.1273
Echinococcus multilocularis	ornithine aminotransferase	0.0022	0.03	0.03
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0017	0.0165	0.0165
Plasmodium vivax	ataxin-2 like protein, putative	0.005	0.0987	1
Schistosoma mansoni	ap endonuclease	0.0018	0.0209	0.0209
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0219	0.1566
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0617	0.1169
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0017	0.0181	0.0181
Plasmodium vivax	ornithine aminotransferase, putative	0.0022	0.03	0.1173
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0219	0.0415
Loa Loa (eye worm)	hypothetical protein	0.012	0.2677	0.5075
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0617	0.1215
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0.0209	0.5
Schistosoma mansoni	hypothetical protein	0.0017	0.0166	0.0166
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0166	0.0314
Schistosoma mansoni	cpg binding protein	0.003	0.0478	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0434	0.0824
Loa Loa (eye worm)	hypothetical protein	0.012	0.2677	0.5075
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0219	0.1566
Echinococcus granulosus	intermediate filament protein	0.0028	0.0434	0.0434
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0617	0.1169
Plasmodium falciparum	ataxin-2 like protein, putative	0.005	0.0987	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0617	0.1169
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0617	0.1215
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0422	0.08
Mycobacterium tuberculosis	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA	0.0156	0.3565	0.6674
Loa Loa (eye worm)	bromodomain containing protein	0.0017	0.018	0.0341
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0209	0.0209
Mycobacterium ulcerans	hypothetical protein	0.0156	0.3565	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0141	0.3204	0.6073
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.0686	0.0686
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0617	0.571
Brugia malayi	beta-lactamase family protein	0.0035	0.0617	0.1169
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0023	0.031	0.031
Loa Loa (eye worm)	CXXC zinc finger family protein	0.003	0.0478	0.0907
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0617	0.0617
Brugia malayi	hypothetical protein	0.0033	0.0552	0.1046
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0141	0.3204	0.3204
Giardia lamblia	DINP protein human, muc B family	0.0019	0.0219	1
Schistosoma mansoni	zinc finger protein	0.0021	0.0267	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0219	0.0415
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0219	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0617	0.1169
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0219	0.1103
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0219	0.0219
Brugia malayi	beta-lactamase	0.0035	0.0617	0.1169
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0209	0.0396
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0219	0.1103
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0617	0.1215
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0219	0.1566
Schistosoma mansoni	hypothetical protein	0.0017	0.0166	0.0166
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0024	0.0337	0.0337
Echinococcus multilocularis	lamin dm0	0.0028	0.0434	0.0434
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0141	0.3204	0.3204
Trypanosoma brucei	ISWI complex protein	0.0015	0.0124	0.052
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0063	0.1284	0.1284
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0617	0.0811
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0617	0.1169
Onchocerca volvulus	Huntingtin homolog	0.012	0.2677	1
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0617	0.5239
Leishmania major	DNA polymerase kappa, putative	0.0019	0.0219	0.1103
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0141	0.3204	0.3204
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0219	0.0415

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 618969