Detailed information for compound 619112

Basic information

Technical information
  • TDR Targets ID: 619112
  • Name: 4-(dimethylsulfamoyl)-N-[5-[2-[(3-methylpheny l)amino]-2-oxoethyl]sulfanyl-1,3,4-thiadiazol -2-yl]benzamide
  • MW: 491.607 | Formula: C20H21N5O4S3
  • H donors: 2 H acceptors: 6 LogP: 2.8 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cccc(c1)C)CSc1nnc(s1)NC(=O)c1ccc(cc1)S(=O)(=O)N(C)C
  • InChi: 1S/C20H21N5O4S3/c1-13-5-4-6-15(11-13)21-17(26)12-30-20-24-23-19(31-20)22-18(27)14-7-9-16(10-8-14)32(28,29)25(2)3/h4-11H,12H2,1-3H3,(H,21,26)(H,22,23,27)
  • InChiKey: DCCXEMQHDNLYJZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-(dimethylsulfamoyl)-N-[5-[2-[(3-methylphenyl)amino]-2-oxo-ethyl]sulfanyl-1,3,4-thiadiazol-2-yl]benzamide
  • 4-(dimethylsulfamoyl)-N-[5-[[2-[(3-methylphenyl)amino]-2-oxoethyl]thio]-1,3,4-thiadiazol-2-yl]benzamide
  • 4-(dimethylsulfamoyl)-N-[5-[[2-keto-2-[(3-methylphenyl)amino]ethyl]thio]-1,3,4-thiadiazol-2-yl]benzamide
  • Oprea1_691849

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0141 0.3149 0.6133
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0029 0.0057
Echinococcus granulosus methyl CpG binding domain protein 2 0.0016 0.0161 0.0161
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.1049 0.2043
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0203 0.1457
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0172 0.0335
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0961 1
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.06 0.0811
Brugia malayi hypothetical protein 0.0039 0.0692 0.1347
Entamoeba histolytica hypothetical protein 0.0039 0.0692 1
Schistosoma mansoni lamin 0.0028 0.044 0.044
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0599 0.0599
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0023 0.0306 0.0306
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.06 0.5933
Mycobacterium ulcerans hypothetical protein 0.0035 0.06 0.1179
Loa Loa (eye worm) hypothetical protein 0.0028 0.044 0.0858
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0244 0.0475
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0213 0.1103
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.06 0.1179
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0161 0.0161
Echinococcus granulosus lamin 0.0028 0.044 0.044
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0023 0.0306 0.021
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0172 0.0335
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0177 0.0177
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.06 0.0811
Schistosoma mansoni hypothetical protein 0.0017 0.0172 0.0172
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0643 0.1252
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.1049 0.2043
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.06 0.1179
Echinococcus multilocularis ornithine aminotransferase 0.0023 0.0306 0.0306
Brugia malayi intermediate filament protein 0.0028 0.044 0.0858
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0213 0.1566
Brugia malayi PHD-finger family protein 0.0026 0.0384 0.0748
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0213 0.1566
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.06 0.571
Entamoeba histolytica hypothetical protein 0.0039 0.0692 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0329 0.0329
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0213 0.1566
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.06 0.06
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0961 1
Echinococcus granulosus GPCR family 2 0.0017 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0019 0.0213 0.0415
Toxoplasma gondii ABC1 family protein 0.0035 0.06 0.4056
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0213 0.002
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0213 0.0197
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0213 0.0029
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0023 0.0306 0.0597
Trypanosoma brucei ISWI complex protein 0.0015 0.012 0.052
Echinococcus multilocularis musashi 0.0028 0.044 0.044
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0213 0.1566
Loa Loa (eye worm) hypothetical protein 0.0028 0.0428 0.0834
Schistosoma mansoni cpg binding protein 0.003 0.0484 0.0484
Mycobacterium tuberculosis Conserved protein 0.0035 0.06 0.0811
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.3149 0.3149
Brugia malayi Bromodomain containing protein 0.0074 0.1545 0.3009
Echinococcus multilocularis Aminotransferase class III 0.0023 0.0306 0.0306
Loa Loa (eye worm) hypothetical protein 0.0017 0.0172 0.0335
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0203 0.0203
Loa Loa (eye worm) hypothetical protein 0.0037 0.0655 0.1276
Echinococcus granulosus cpg binding protein 0.0033 0.057 0.057
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0692 0.0692
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0213 0.1103
Onchocerca volvulus 0.0028 0.044 0.169
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.044 0.0858
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0023 0.0306 0.1052
Loa Loa (eye worm) hypothetical protein 0.005 0.0961 0.1871
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0213 0.1566
Loa Loa (eye worm) hypothetical protein 0.0017 0.0177 0.0344
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.06 0.571
Echinococcus multilocularis ornithine aminotransferase 0.0023 0.0306 0.0306
Loa Loa (eye worm) hypothetical protein 0.0039 0.071 0.1383
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0213 0.1103
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0161 0.0161
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.1049 0.2043
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0213 0.1566
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.06 0.1179
Schistosoma mansoni hypothetical protein 0.0426 1 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.06 0.1169
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.06 0.06
Schistosoma mansoni intermediate filament proteins 0.0028 0.044 0.044
Echinococcus granulosus intermediate filament protein 0.0028 0.044 0.044
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0023 0.0306 0.0306
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0329 0.0329
Brugia malayi CXXC zinc finger family protein 0.003 0.0484 0.0943
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0159 0.3569 0.6876
Echinococcus multilocularis cpg binding protein 0.0033 0.057 0.057
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0213 0.0213
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0172 0.0172
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0172 0.0172
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0203 0.5
Echinococcus granulosus Aminotransferase class III 0.0023 0.0306 0.0306
Loa Loa (eye worm) hypothetical protein 0.0013 0.0079 0.0154
Loa Loa (eye worm) hypothetical protein 0.0053 0.1049 0.2043
Loa Loa (eye worm) hypothetical protein 0.0014 0.0091 0.0178
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0961 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0091 0.0091
Leishmania major hypothetical protein, conserved 0.0035 0.06 0.571
Schistosoma mansoni hypothetical protein 0.0022 0.0302 0.0302
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0213 0.1566
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0213 0.0029
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0213 0.0029
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0023 0.0306 1
Echinococcus multilocularis zinc finger protein 0.0021 0.026 0.026
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0213 0.1566
Plasmodium vivax hypothetical protein, conserved 0.0035 0.06 0.5239
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0302 0.0302
Mycobacterium ulcerans acetylornithine aminotransferase 0.0023 0.0306 0.0306
Echinococcus multilocularis dna polymerase eta 0.0019 0.0213 0.0213
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0213 0.1566
Echinococcus multilocularis lamin dm0 0.0028 0.044 0.044
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0961 1
Brugia malayi hypothetical protein 0.005 0.0961 0.1871
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0203 0.0989
Onchocerca volvulus 0.0035 0.06 0.2304
Brugia malayi follicle stimulating hormone receptor 0.0224 0.5135 1
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0023 0.0306 0.0306
Entamoeba histolytica hypothetical protein 0.0039 0.0692 1
Schistosoma mansoni ap endonuclease 0.0018 0.0203 0.0203
Mycobacterium tuberculosis Conserved protein 0.0035 0.06 0.0811
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0091 0.0091
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0224 0.5135 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0203 0.0989
Onchocerca volvulus 0.0035 0.06 0.2304
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0023 0.0306 0.021
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.06 0.1179
Giardia lamblia DINP protein human, muc B family 0.0019 0.0213 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.3149 0.3149
Schistosoma mansoni zinc finger protein 0.0015 0.012 0.012
Echinococcus multilocularis lamin 0.0028 0.044 0.044
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0172 0.0172
Plasmodium falciparum ornithine aminotransferase 0.0023 0.0306 0.1359
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0213 0.1103
Brugia malayi hypothetical protein 0.0118 0.2606 0.5075
Mycobacterium leprae Probable lipase LipE 0.0035 0.06 0.0901
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.06 0.0811
Schistosoma mansoni bromodomain containing protein 0.0063 0.1274 0.1274
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0213 0.1103
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.3149 0.3149
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0213 0.0415
Brugia malayi beta-lactamase family protein 0.0035 0.06 0.1169
Trichomonas vaginalis esterase, putative 0.0035 0.06 0.1179
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0484 0.0943
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.06 0.0811
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0023 0.0306 0.5
Brugia malayi beta-lactamase 0.0035 0.06 0.1169
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0213 0.0213
Echinococcus granulosus zinc finger protein 0.0021 0.026 0.026
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0213 0.0415
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0213 0.0213
Schistosoma mansoni cpg binding protein 0.0033 0.057 0.057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.3149 0.3149
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0213 0.1103
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0213 0.002
Loa Loa (eye worm) hypothetical protein 0.0035 0.06 0.1169
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0203 0.0396
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.06 0.0811
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.044 0.0858
Onchocerca volvulus 0.003 0.0484 0.1858
Loa Loa (eye worm) hypothetical protein 0.0035 0.06 0.1169
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0961 1
Echinococcus granulosus lamin dm0 0.0028 0.044 0.044
Echinococcus granulosus dna polymerase eta 0.0019 0.0213 0.0213
Loa Loa (eye worm) hypothetical protein 0.0118 0.2606 0.5075
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0177 0.0177
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0159 0.3569 1
Onchocerca volvulus 0.0035 0.06 0.2304
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.06 0.1179
Schistosoma mansoni lamin 0.0028 0.044 0.044
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.3149 0.3149
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0692 0.0692
Mycobacterium ulcerans hypothetical protein 0.0159 0.3569 1
Schistosoma mansoni ap endonuclease 0.0018 0.0203 0.0203
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0961 1
Schistosoma mansoni hypothetical protein 0.0017 0.0172 0.0172
Plasmodium vivax ornithine aminotransferase, putative 0.0023 0.0306 0.1359
Echinococcus granulosus dna polymerase kappa 0.0019 0.0213 0.0213
Schistosoma mansoni hypothetical protein 0.0037 0.0643 0.0643
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0213 0.1566
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0302 0.0302
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.06 0.0811
Echinococcus multilocularis GPCR, family 2 0.0017 0.0172 0.0172
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0203 0.0203
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0213 0.1566
Loa Loa (eye worm) hypothetical protein 0.0118 0.2606 0.5075
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.06 0.1179
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0213 0.0029
Schistosoma mansoni hypothetical protein 0.0017 0.0172 0.0172
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0203 0.0396
Schistosoma mansoni hypothetical protein 0.0017 0.0172 0.0172
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.0013 0.0079 0.0154
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0213 0.1566
Onchocerca volvulus 0.0028 0.044 0.169
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0213 0.0213
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0159 0.3569 1
Brugia malayi Bromodomain containing protein 0.0037 0.0654 0.1273
Loa Loa (eye worm) hypothetical protein 0.0043 0.0795 0.1549
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0023 0.0306 0.021
Trypanosoma brucei unspecified product 0.0019 0.0213 0.1566
Entamoeba histolytica hypothetical protein 0.0039 0.0692 1
Brugia malayi hypothetical protein 0.0032 0.0537 0.1046
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0213 0.1566
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.06 0.06
Schistosoma mansoni cpg binding protein 0.0033 0.057 0.057
Schistosoma mansoni hypothetical protein 0.0015 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0068 0.1405 0.2737
Loa Loa (eye worm) hypothetical protein 0.0035 0.06 0.1169
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0175 0.0341
Leishmania major hypothetical protein, conserved 0.005 0.0961 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.1191 0.1191
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0213 0.0213
Mycobacterium tuberculosis Conserved protein 0.0035 0.06 0.0811
Onchocerca volvulus Huntingtin homolog 0.0118 0.2606 1
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0023 0.0306 0.0306
Schistosoma mansoni DNA polymerase eta 0.0019 0.0213 0.0213
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.06 0.1179
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0203 0.0989
Loa Loa (eye worm) hypothetical protein 0.0037 0.0643 0.1252
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0692 0.0692
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0213 0.1566
Brugia malayi beta-lactamase family protein 0.0035 0.06 0.1169
Schistosoma mansoni hypothetical protein 0.002 0.0244 0.0244
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.3149 0.3149
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0177 0.0177
Mycobacterium tuberculosis Probable aminotransferase 0.0159 0.3569 0.6876
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.129 0.129
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0961 0.7742
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0172 0.0172
Loa Loa (eye worm) beta-lactamase 0.0035 0.06 0.1169
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0141 0.3149 0.6133
Schistosoma mansoni hypothetical protein 0.0039 0.0692 0.0692
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.1182 1
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0172 0.0335
Onchocerca volvulus Huntingtin homolog 0.0118 0.2606 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0329 0.0329
Mycobacterium ulcerans lipase LipD 0.0035 0.06 0.1179
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.5098 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.1191 0.1191
Mycobacterium ulcerans L-lysine aminotransferase 0.0023 0.0306 0.0306
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0213 0.0415
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0016 0.0161 0.0161
Leishmania major DNA polymerase kappa, putative 0.0019 0.0213 0.1103
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.06 0.1169
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0023 0.0306 0.0306
Schistosoma mansoni zinc finger protein 0.0021 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0035 0.06 0.1169
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.06 0.1169
Echinococcus multilocularis dnaJ subfamily B 0.0426 1 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.06 0.1169
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0599 0.0599
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0023 0.0306 0.021
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0127 0.0248
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0159 0.3569 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.06 0.06
Mycobacterium leprae conserved hypothetical protein 0.0035 0.06 0.0901
Echinococcus granulosus ornithine aminotransferase 0.0023 0.0306 0.0306
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0127 0.0248
Mycobacterium ulcerans beta-lactamase 0.0035 0.06 0.1179
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.06 0.0811
Loa Loa (eye worm) intermediate filament protein 0.0028 0.044 0.0858
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.3149 0.3149
Leishmania major DNA polymerase eta, putative 0.0019 0.0213 0.1103

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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