Detailed information for compound 63097

Basic information

Technical information
  • TDR Targets ID: 63097
  • Name: N-[[(2R,3R,4S,5R)-5-(5-ethyl-2,4-dioxopyrimid in-1-yl)-4-fluoro-3-hydroxyoxolan-2-yl]methyl ]-4-methyl-9H-xanthene-9-carboxamide
  • MW: 495.5 | Formula: C26H26FN3O6
  • H donors: 3 H acceptors: 4 LogP: 2.79 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1cn(c(=O)[nH]c1=O)[C@@H]1O[C@@H]([C@H]([C@@H]1F)O)CNC(=O)C1c2ccccc2Oc2c1cccc2C
  • InChi: 1S/C26H26FN3O6/c1-3-14-12-30(26(34)29-23(14)32)25-20(27)21(31)18(36-25)11-28-24(33)19-15-8-4-5-10-17(15)35-22-13(2)7-6-9-16(19)22/h4-10,12,18-21,25,31H,3,11H2,1-2H3,(H,28,33)(H,29,32,34)/t18-,19?,20+,21-,25-/m1/s1
  • InChiKey: UQMKZWIHMVSMKL-YZLYHCBJSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[[(2R,3R,4S,5R)-5-(5-ethyl-2,4-dioxo-pyrimidin-1-yl)-4-fluoro-3-hydroxy-tetrahydrofuran-2-yl]methyl]-4-methyl-9H-xanthene-9-carboxamide
  • N-[[(2R,3R,4S,5R)-5-(5-ethyl-2,4-dioxo-1-pyrimidinyl)-4-fluoro-3-hydroxy-2-tetrahydrofuranyl]methyl]-4-methyl-9H-xanthene-9-carboxamide
  • N-[[(2R,3R,4S,5R)-5-(5-ethyl-2,4-dioxo-pyrimidin-1-yl)-4-fluoro-3-hydroxy-oxolan-2-yl]methyl]-4-methyl-9H-xanthene-9-carboxamide
  • N-[[(2R,3R,4S,5R)-5-(5-ethyl-2,4-diketo-pyrimidin-1-yl)-4-fluoro-3-hydroxy-tetrahydrofuran-2-yl]methyl]-4-methyl-9H-xanthene-9-carboxamide
  • 4-Methyl-9H-xanthene-9-carboxylic acid, [5-(5-ethyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-tetrahydro-furan-2-ylmethyl]-amide
  • AIDS-230184
  • AIDS230184

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human herpesvirus 1 (strain SC16) (HHV-1) (Human herpes simplex virus1) Thymidine kinase Starlite/ChEMBL References
Human herpesvirus 2 Thymidine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Giardia lamblia Deoxynucleoside kinase Get druggable targets OG5_131626 All targets in OG5_131626
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus smad 0.0032 0.0112 0.0236
Brugia malayi hypothetical protein 0.0035 0.0139 0.0099
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0194 0.16 0.1566
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0035 0.0139 0.0229
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.004 0.0182 0.0156
Echinococcus granulosus Smad4 0.0032 0.0112 0.0236
Echinococcus multilocularis dro:myosuppressin receptor 0.0035 0.0139 0.0294
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0047 0.0249 0.0068
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.028 0.0099
Echinococcus granulosus somatostatin receptor 0.0035 0.0139 0.0294
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0061 0.0381 0.0805
Schistosoma mansoni neuropeptide receptor 0.0035 0.0139 0.0229
Schistosoma mansoni alpha-1 adrenergic receptor 0.0035 0.0139 0.0229
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Loa Loa (eye worm) ABC transporter 0.004 0.0182 0.0143
Brugia malayi ORL1-like opioid receptor 0.0035 0.0139 0.0099
Echinococcus granulosus neuropeptides capa receptor 0.0035 0.0139 0.0294
Schistosoma mansoni myosin xvIII 0.0035 0.0139 0.0229
Plasmodium falciparum plasmepsin II 0.0049 0.027 0.1092
Brugia malayi hypothetical protein 0.0035 0.0139 0.0099
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0383 0.0792
Echinococcus multilocularis fmrfamide receptor 0.0035 0.0139 0.0294
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0139 0.0229
Echinococcus multilocularis ATP binding cassette sub family B 0.004 0.0182 0.0385
Brugia malayi GnHR receptor homolog 0.0035 0.0139 0.0099
Echinococcus multilocularis ankyrin repeat protein 0.0155 0.1241 0.2623
Plasmodium vivax sphingomyelin synthase 1, putative 0.0058 0.0347 0.2054
Entamoeba histolytica ATP-binding cassette protein, putative 0.004 0.0182 0.0013
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0127 0.0985 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0139 0.0294
Brugia malayi sulfakinin receptor protein 0.0035 0.0139 0.0099
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0035 0.0139 0.0229
Entamoeba histolytica multidrug resistance protein, putative 0.004 0.0182 0.0013
Entamoeba histolytica P-glycoprotein-2 0.0127 0.0985 0.0864
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0058 0.0347 0.0308
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.004 0.0182 0.5
Echinococcus multilocularis multidrug resistance protein 1 0.0127 0.0985 0.2081
Echinococcus granulosus sphingomyelin synthase protein 1 0.0058 0.0347 0.0733
Schistosoma mansoni multidrug resistance protein 0.0038 0.017 0.0299
Schistosoma mansoni multidrug resistance protein 0.004 0.0182 0.0328
Schistosoma mansoni biogenic amine (5HT) receptor 0.0035 0.0139 0.0229
Trichomonas vaginalis abcb9, putative 0.0127 0.0985 1
Entamoeba histolytica P-glycoprotein-5 0.0127 0.0985 0.0864
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0032 0.0112 0.0166
Trypanosoma brucei PAB1-binding protein , putative 0.01 0.0732 0.056
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0035 0.0139 0.0099
Echinococcus granulosus tm gpcr rhodopsin 0.0535 0.4733 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Echinococcus multilocularis sex peptide receptor 0.0035 0.0139 0.0294
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Echinococcus multilocularis somatostatin receptor 0.0035 0.0139 0.0294
Trichomonas vaginalis ABC transporter, putative 0.0127 0.0985 1
Brugia malayi hypothetical protein 0.0035 0.0139 0.0099
Loa Loa (eye worm) hypothetical protein 0.0049 0.027 0.023
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.1095 0.093
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0139 0.0294
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0383 0.0344
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0049 0.027 0.023
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0035 0.0139 0.0294
Loa Loa (eye worm) G-protein coupled receptor 0.0035 0.0139 0.0099
Echinococcus granulosus g protein coupled receptor 0.0035 0.0139 0.0294
Schistosoma mansoni amine GPCR 0.0035 0.0139 0.0229
Schistosoma mansoni multidrug resistance protein 0.0127 0.0985 0.2185
Echinococcus multilocularis neuropeptide Y receptor 0.0035 0.0139 0.0294
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0035 0.0139 0.0294
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Brugia malayi RE15519p 0.0035 0.0139 0.0099
Schistosoma mansoni smad1 5 8 and 0.0032 0.0112 0.0166
Schistosoma mansoni hypothetical protein 0.0035 0.0139 0.0229
Entamoeba histolytica ABC transporter, putative 0.004 0.0182 0.0013
Loa Loa (eye worm) hypothetical protein 0.0038 0.017 0.013
Schistosoma mansoni biogenic amine receptor 0.0035 0.0139 0.0229
Echinococcus granulosus GPCR family 2 0.0061 0.0381 0.0805
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0035 0.0139 0.0294
Echinococcus granulosus ATP binding cassette sub family B 0.004 0.0182 0.0385
Echinococcus granulosus neuropeptide s receptor 0.0035 0.0139 0.0294
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0127 0.0985 0.2081
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Brugia malayi ABC transporter transmembrane region family protein 0.004 0.0182 0.0143
Loa Loa (eye worm) hypothetical protein 0.0058 0.0347 0.0308
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0139 0.0229
Entamoeba histolytica P-glycoprotein 6, putative 0.004 0.0182 0.0013
Echinococcus granulosus multidrug resistance protein 1 0.0089 0.0632 0.1335
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0535 0.4733 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0047 0.0249 0.0527
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0127 0.0985 0.0817
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Echinococcus granulosus orexin receptor type 2 0.0035 0.0139 0.0294
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0229 0.192 0.4057
Echinococcus multilocularis neuropeptide receptor A26 0.0035 0.0139 0.0294
Schistosoma mansoni ATP-binding cassette transporter 0.0026 0.0053 0.0029
Echinococcus multilocularis neuropeptide receptor 0.0035 0.0139 0.0294
Entamoeba histolytica P-glycoprotein-2 0.0127 0.0985 0.0864
Mycobacterium tuberculosis Iron-regulated transporter IrtA 0.004 0.0182 0.1268
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0229 0.192 0.4349
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0139 0.0294
Leishmania major phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0547 0.4842 0.4746
Echinococcus granulosus TGF beta signal transducer SmadC 0.0032 0.0112 0.0236
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0035 0.0139 0.0229
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0547 0.4842 0.4746
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0127 0.0985 1
Schistosoma mansoni ADAM17 peptidase (M12 family) 0.018 0.1471 0.331
Brugia malayi hypothetical protein 0.0035 0.0139 0.0099
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0127 0.0985 0.2081
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0139 0.0294
Echinococcus multilocularis ATP binding cassette sub family B 0.004 0.0182 0.0385
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0035 0.0139 0.0099
Echinococcus granulosus multidrug resistance protein 1 0.0089 0.0632 0.1335
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 3 0.0058 0.0347 0.0308
Echinococcus multilocularis allatostatin A receptor 0.0035 0.0139 0.0294
Plasmodium falciparum ataxin-2 like protein, putative 0.01 0.0732 0.6849
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0139 0.0294
Loa Loa (eye worm) hypothetical protein 0.0567 0.5022 0.5001
Echinococcus multilocularis adam 0.0031 0.0104 0.0221
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0035 0.0139 0.0229
Brugia malayi ABC transporter transmembrane region family protein 0.004 0.0182 0.0143
Entamoeba histolytica hypothetical protein, conserved 0.1066 0.9608 1
Echinococcus granulosus ATP binding cassette sub family B 0.0038 0.017 0.0358
Schistosoma mansoni neuropeptide receptor 0.0035 0.0139 0.0229
Echinococcus granulosus 7tm_1 domain containing protein 0.0035 0.0139 0.0294
Brugia malayi TAR-binding protein 0.0062 0.0383 0.0344
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.004 0.0182 0.0328
Echinococcus granulosus sex peptide receptor 0.0035 0.0139 0.0294
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0155 0.1241 0.2779
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0116 0.0881 0.0844
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0127 0.0985 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0127 0.0985 0.2081
Brugia malayi G-protein coupled receptor 0.0035 0.0139 0.0099
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0062 0.0384 0.0345
Loa Loa (eye worm) hypothetical protein 0.1108 1 1
Echinococcus granulosus neuropeptide Y receptor 0.0035 0.0139 0.0294
Loa Loa (eye worm) hypothetical protein 0.0155 0.1244 0.1209
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0049 0.027 0.1092
Brugia malayi metalloprotease disintegrin 16 with thrombospondin type I motif 0.0085 0.0598 0.056
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0139 0.0229
Brugia malayi ABC transporter family protein 0.004 0.0182 0.0143
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0194 0.16 0.1566
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.1239 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0047 0.0249 0.0527
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0035 0.0139 0.0229
Entamoeba histolytica hypothetical protein 0.0058 0.0347 0.0188
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0116 0.0881 0.1861
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0058 0.0347 0.2178
Trichomonas vaginalis abcb9, putative 0.0127 0.0985 1
Brugia malayi P-glycoprotein-like protein 0.004 0.0182 0.0143
Echinococcus granulosus adam 0.0031 0.0104 0.0221
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0127 0.0985 1
Echinococcus granulosus glutamate NMDA receptor subunit 0.0024 0.004 0.0085
Brugia malayi neuropeptide F receptor 0.0035 0.0139 0.0099
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0547 0.4842 0.4746
Plasmodium falciparum sphingomyelin synthase 2, putative 0.0058 0.0347 0.2054
Echinococcus multilocularis serotonin receptor 0.0035 0.0139 0.0294
Loa Loa (eye worm) hypothetical protein 0.0038 0.017 0.013
Loa Loa (eye worm) hypothetical protein 0.0229 0.192 0.1888
Leishmania major mitochondrial DNA polymerase beta 0.0294 0.2517 0.2378
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0127 0.0985 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Loa Loa (eye worm) multidrug resistance protein 3 0.0127 0.0985 0.0948
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0139 0.0294
Leishmania major hypothetical protein, conserved 0.01 0.0732 0.056
Echinococcus multilocularis neuropeptide receptor 0.0035 0.0139 0.0294
Leishmania major C-8 sterol isomerase-like protein 0.1108 1 1
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.004 0.0182 0.1268
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0139 0.0294
Echinococcus granulosus neuropeptide Y receptor 0.0035 0.0139 0.0294
Trichomonas vaginalis hypothetical protein 0.0058 0.0347 0.2178
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0139 0.0294
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0023 0.0029 0.5
Schistosoma mansoni hypothetical protein 0.0061 0.0381 0.0788
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0045 0.0227 0.048
Echinococcus multilocularis orexin receptor type 2 0.0035 0.0139 0.0294
Schistosoma mansoni smad1 5 8 and 0.0032 0.0112 0.0166
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0127 0.0985 1
Echinococcus granulosus multidrug resistance protein 1 0.0127 0.0985 0.2081
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Entamoeba histolytica P-glycoprotein 6, putative 0.004 0.0182 0.0013
Toxoplasma gondii hypothetical protein 0.0058 0.0347 0.2054
Schistosoma mansoni hypothetical protein 0.0061 0.0381 0.0788
Schistosoma mansoni spingomyelin synthetase-related 0.0058 0.0347 0.071
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Echinococcus granulosus transient receptor potential cation channel 0.0158 0.127 0.2684
Entamoeba histolytica hypothetical membrane-spanning protein 0.0058 0.0347 0.0188
Schistosoma mansoni Smad4 0.0032 0.0112 0.0166
Schistosoma mansoni neuropeptide F-like receptor 0.0035 0.0139 0.0229
Brugia malayi Dopamine receptor protein 2 0.0035 0.0139 0.0099
Loa Loa (eye worm) hypothetical protein 0.0058 0.0347 0.0308
Loa Loa (eye worm) hypothetical protein 0.0058 0.0347 0.0308
Echinococcus multilocularis 0.004 0.0182 0.0385
Echinococcus granulosus neuropeptides capa receptor 0.0035 0.0139 0.0294
Schistosoma mansoni neuropeptide receptor 0.0035 0.0139 0.0229
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Loa Loa (eye worm) transcription factor SMAD2 0.0471 0.4148 0.4124
Echinococcus multilocularis mothers against decapentaplegic 5 0.0032 0.0112 0.0236
Echinococcus multilocularis neuropeptide s receptor 0.0035 0.0139 0.0294
Echinococcus granulosus serotonin receptor 0.0035 0.0139 0.0294
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0029 0.0083 0.0175
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0127 0.0985 1
Schistosoma mansoni hypothetical protein 0.0045 0.0227 0.0433
Entamoeba histolytica P-glycoprotein-1 0.0127 0.0985 0.0864
Echinococcus multilocularis G protein coupled receptor 139 0.0035 0.0139 0.0294
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0058 0.0347 0.2178
Plasmodium vivax sphingomyelin synthase 2, putative 0.0058 0.0347 0.2054
Echinococcus granulosus multidrug resistance protein 1 0.0127 0.0985 0.2081
Echinococcus multilocularis Smad4 0.0032 0.0112 0.0236
Brugia malayi MH1 domain containing protein 0.0032 0.0112 0.0072
Echinococcus granulosus multidrug resistance associated protein 1 0.004 0.0182 0.0385
Schistosoma mansoni adenoreceptor 0.0035 0.0139 0.0229
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0058 0.0347 0.0308
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0197 0.0015
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0047 0.0249 0.1821
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0035 0.0139 0.0294
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0127 0.0985 0.2081
Echinococcus granulosus tm gpcr rhodopsin 0.0035 0.0139 0.0294
Schistosoma mansoni cathepsin D (A01 family) 0.0145 0.1152 0.2573
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0035 0.0139 0.0229
Trypanosoma cruzi PAB1-binding protein , putative 0.01 0.0732 0.056
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0061 0.0381 0.0805
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0197 0.0015
Echinococcus granulosus biogenic amine 5HT receptor 0.0035 0.0139 0.0294
Brugia malayi Sphingomyelin synthase-related 1 0.0058 0.0347 0.0308
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0047 0.0249 0.0835
Brugia malayi AKH receptor 0.0035 0.0139 0.0099
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0127 0.0985 1
Onchocerca volvulus 0.0127 0.0985 0.2907
Schistosoma mansoni hypothetical protein 0.0495 0.4363 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0035 0.0139 0.0294
Echinococcus granulosus peptide allatostatin:somatostatin 0.0035 0.0139 0.0294
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0383 0.0792
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0035 0.0139 0.0229
Loa Loa (eye worm) hypothetical protein 0.004 0.0182 0.0143
Schistosoma mansoni biogenic amine receptor 0.0035 0.0139 0.0229
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0127 0.0985 0.2081
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0035 0.0139 0.0229
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0127 0.0985 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0127 0.0985 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0116 0.0881 0.1861
Echinococcus granulosus neuropeptide FF receptor 2 0.0035 0.0139 0.0294
Echinococcus granulosus adam 17 protease 0.0198 0.1636 0.3456
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0383 0.0792
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0127 0.0985 0.2081
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0139 0.0294
Brugia malayi hypothetical protein 0.0035 0.0139 0.0099
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0321 0.2764 0.584
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0383 0.0792
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0058 0.0347 0.2178
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0049 0.027 0.1231
Brugia malayi hypothetical protein 0.0035 0.0139 0.0099
Echinococcus granulosus neuropeptide receptor 0.0035 0.0139 0.0294
Schistosoma mansoni multidrug resistance protein 0.004 0.0182 0.0328
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0035 0.0139 0.0294
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0035 0.0139 0.0294
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0035 0.0139 0.0229
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0139 0.0229
Brugia malayi multidrug resistance related protein 1 0.004 0.0182 0.0143
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0116 0.0881 0.0844
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0127 0.0985 0.2081
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0035 0.0139 0.0294
Echinococcus multilocularis nmda type glutamate receptor 0.0032 0.0111 0.0236
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0116 0.0881 0.1861
Echinococcus granulosus mothers against decapentaplegic 5 0.0032 0.0112 0.0236
Brugia malayi larval opioid receptor 0.0035 0.0139 0.0099
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0029 0.0083 0.0175
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0035 0.0139 0.0294
Brugia malayi MH2 domain containing protein 0.0032 0.0112 0.0072
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0139 0.0294
Loa Loa (eye worm) hypothetical protein 0.0061 0.0381 0.0342
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0038 0.017 0.0299
Echinococcus granulosus 7TM GPCR rhodopsin 0.0035 0.0139 0.0294
Loa Loa (eye worm) hypothetical protein 0.0058 0.0347 0.0308
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0383 0.0809
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0035 0.0139 0.0294
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0127 0.0985 1
Schistosoma mansoni smdr1 0.004 0.0182 0.0328
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0127 0.0985 1
Mycobacterium ulcerans hypothetical protein 0.0155 0.1239 1
Schistosoma mansoni histamine h1 receptor 0.0035 0.0139 0.0229
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Echinococcus multilocularis multidrug resistance protein 1 0.0127 0.0985 0.2081
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Schistosoma mansoni multidrug resistance protein 0.004 0.0182 0.0328
Brugia malayi hypothetical protein 0.0035 0.0139 0.0099
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Brugia malayi follicle stimulating hormone receptor 0.0035 0.0139 0.0099
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0127 0.0985 0.2081
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0032 0.0112 0.0236
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0127 0.0985 1
Echinococcus granulosus g protein coupled receptor 0.0035 0.0139 0.0294
Loa Loa (eye worm) hypothetical protein 0.01 0.0732 0.0694
Giardia lamblia Multidrug resistance-associated protein 1 0.004 0.0182 0.0033
Echinococcus multilocularis neuropeptide Y receptor 0.0035 0.0139 0.0294
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0035 0.0139 0.0294
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Loa Loa (eye worm) hypothetical protein 0.0127 0.0985 0.0948
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 0.0249 0.0527
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0089 0.0632 0.5674
Brugia malayi Tachykinin-like peptides receptor 99D 0.0035 0.0139 0.0099
Echinococcus multilocularis ATP binding cassette sub family B 0.0126 0.0972 0.2054
Trichomonas vaginalis ABC transporter, putative 0.0127 0.0985 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0127 0.0985 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0035 0.0139 0.0229
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0047 0.0249 0.0068
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0047 0.0249 0.0068
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0127 0.0985 1
Echinococcus granulosus tm gpcr rhodopsin 0.0035 0.0139 0.0294
Echinococcus granulosus allatostatin A receptor 0.0035 0.0139 0.0294
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0139 0.0294
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0116 0.0881 0.1861
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0035 0.0139 0.0294
Echinococcus granulosus g-protein coupled receptor 0.0035 0.0139 0.0294
Plasmodium falciparum ataxin-2 like protein, putative 0.01 0.0732 0.6849
Trypanosoma cruzi C-8 sterol isomerase, putative 0.1108 1 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0061 0.0381 0.0805
Schistosoma mansoni hypothetical protein 0.0035 0.0139 0.0229
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0035 0.0139 0.0229
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0127 0.0985 1
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0058 0.0347 0.2178
Schistosoma mansoni amine GPCR 0.0035 0.0139 0.0229
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.1095 0.093
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.006 0.0367 0.0328
Loa Loa (eye worm) G-protein coupled receptor 0.0035 0.0139 0.0099
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0058 0.0347 0.0308
Echinococcus granulosus geminin 0.0495 0.4363 0.9217
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0229 0.192 0.4057
Loa Loa (eye worm) latrophilin receptor protein 2 0.0061 0.0381 0.0342
Brugia malayi Isocitrate dehydrogenase 0.0047 0.0249 0.021
Echinococcus multilocularis transient receptor potential cation channel 0.0158 0.127 0.2684
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0127 0.0985 1
Schistosoma mansoni multidrug resistance protein 0.0127 0.0985 0.2185
Loa Loa (eye worm) RNA binding protein 0.0062 0.0383 0.0344
Trypanosoma brucei inositol phosphorylceramide synthase 0.0058 0.0347 0.0168
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0023 0.0029 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0139 0.0294
Schistosoma mansoni hypothetical protein 0.0133 0.1036 0.2303
Brugia malayi G-protein coupled receptor 0.0035 0.0139 0.0099
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0139 0.0294
Brugia malayi RNA binding protein 0.0062 0.0383 0.0344
Entamoeba histolytica hypothetical protein 0.0058 0.0347 0.0188
Echinococcus granulosus dro:myosuppressin receptor 0.0035 0.0139 0.0294
Entamoeba histolytica ATP-binding cassette protein, putative 0.004 0.0182 0.0013
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.004 0.0182 0.1268
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0047 0.0249 0.0527
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 0.0249 0.0527
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Schistosoma mansoni smdr2 0.0127 0.0985 0.2185
Echinococcus multilocularis glutamate receptor 2 0.0029 0.0083 0.0175
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0029 0.0083 0.0175
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0383 0.0792
Schistosoma mansoni hypothetical protein 0.0035 0.0139 0.0229
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0035 0.0139 0.0294
Schistosoma mansoni hypothetical protein 0.005 0.028 0.0555
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0127 0.0985 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0035 0.0139 0.0294
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0047 0.0249 0.0483
Brugia malayi hypothetical protein 0.004 0.0182 0.0143
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0035 0.0139 0.0099
Schistosoma mansoni opsin-like receptor 0.0035 0.0139 0.0229
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0383 0.0344
Echinococcus multilocularis g protein coupled receptor 0.0035 0.0139 0.0294
Echinococcus multilocularis g protein coupled receptor 0.0035 0.0139 0.0294
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0127 0.0985 0.0948
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 0.2517 0.2378
Entamoeba histolytica P-glycoprotein 5, putative 0.0127 0.0985 0.0864
Schistosoma mansoni hypothetical protein 0.0061 0.0381 0.0788
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0035 0.0139 0.0294
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0085 0.0598 0.1263
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0032 0.0111 0.0236
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Loa Loa (eye worm) TYRA-2 protein 0.0035 0.0139 0.0099
Brugia malayi putative neuropeptide receptor 0.0035 0.0139 0.0099
Brugia malayi G protein-coupled receptor 0.0035 0.0139 0.0099
Plasmodium falciparum plasmepsin I 0.0049 0.027 0.1092
Entamoeba histolytica P-glyco protein 6, putative 0.0127 0.0985 0.0864
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0035 0.0139 0.0229
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0029 0.0083 0.0175
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0113 0.0855 0.1806
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0383 0.0344
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0139 0.0294
Brugia malayi ABC transporter family protein 0.004 0.0182 0.0143
Echinococcus granulosus alpha 1A adrenergic receptor 0.0035 0.0139 0.0294
Toxoplasma gondii isocitrate dehydrogenase 0.0047 0.0249 0.0835
Echinococcus multilocularis multidrug resistance protein 1 0.0089 0.0632 0.1335
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0347 0.2178
Leishmania major p-glycoprotein 0.0127 0.0985 0.0817
Trypanosoma brucei ceramide phosphorylethanolamine synthase 0.0058 0.0347 0.0168
Echinococcus multilocularis ATP binding cassette sub family B 0.004 0.0182 0.0385
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0049 0.027 0.057
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Brugia malayi hypothetical protein 0.01 0.0732 0.0694
Brugia malayi MH2 domain containing protein 0.0471 0.4148 0.4124
Echinococcus multilocularis neuropeptides capa receptor 0.0035 0.0139 0.0294
Plasmodium falciparum plasmepsin IV 0.0049 0.027 0.1092
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Brugia malayi neuropeptide F receptor 0.0035 0.0139 0.0099
Loa Loa (eye worm) hypothetical protein 0.0194 0.16 0.1566
Giardia lamblia Deoxynucleoside kinase 0.0455 0.3993 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0035 0.0139 0.0294
Giardia lamblia ABC transporter, putative 0.004 0.0182 0.0033
Echinococcus multilocularis g protein coupled receptor 0.0035 0.0139 0.0294
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0047 0.0249 0.0068
Entamoeba histolytica hypothetical protein 0.0058 0.0347 0.0188
Brugia malayi Latrophilin receptor protein 2 0.0061 0.0381 0.0342
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0085 0.0598 0.1263
Schistosoma mansoni multidrug resistance protein 0.004 0.0182 0.0328
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0127 0.0985 1
Brugia malayi MH2 domain containing protein 0.0032 0.0112 0.0072
Brugia malayi ABC transporter 0.0038 0.017 0.013
Entamoeba histolytica P-glycoprotein-2, putative 0.0127 0.0985 0.0864
Loa Loa (eye worm) hypothetical protein 0.0058 0.0347 0.0308
Brugia malayi Calcitonin receptor-like protein seb-1 0.0194 0.16 0.1566
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0058 0.0347 0.2054
Brugia malayi N-terminal motif family protein 0.0352 0.3047 0.3019
Echinococcus multilocularis multidrug resistance associated protein 1 0.004 0.0182 0.0385
Schistosoma mansoni amine GPCR 0.0035 0.0139 0.0229
Schistosoma mansoni neuropeptide receptor 0.0035 0.0139 0.0229
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0197 0.0015
Echinococcus granulosus multidrug resistance associated protein 7 0.004 0.0182 0.0385
Schistosoma mansoni amine GPCR 0.0035 0.0139 0.0229
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.004 0.0182 0.0143
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0547 0.4842 0.4746
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.004 0.0182 0.0143
Loa Loa (eye worm) ABC transporter 0.004 0.0182 0.0143
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0035 0.0139 0.0099
Schistosoma mansoni multidrug resistance protein 0.004 0.0182 0.0328
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0035 0.0139 0.0099
Schistosoma mansoni growth hormone secretagogue receptor 0.0035 0.0139 0.0229
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0139 0.0229
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0061 0.0381 0.0342
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Echinococcus granulosus tar DNA binding protein 0.0062 0.0383 0.0809
Brugia malayi ABC transporter 0.004 0.0182 0.0143
Brugia malayi hypothetical protein 0.0031 0.0104 0.0064
Schistosoma mansoni hypothetical protein 0.0061 0.0381 0.0788
Giardia lamblia Multidrug resistance-associated protein 1 0.004 0.0182 0.0033
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0029 0.0083 0.0175
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.1095 0.093
Brugia malayi putative neuropeptide receptor NPR1 0.0035 0.0139 0.0099
Loa Loa (eye worm) hypothetical protein 0.0126 0.0972 0.0935
Schistosoma mansoni amine GPCR 0.0035 0.0139 0.0229
Echinococcus granulosus ATP binding cassette sub family B 0.004 0.0182 0.0385
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0127 0.0985 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0045 0.0227 0.048
Loa Loa (eye worm) hypothetical protein 0.0058 0.0347 0.0308
Trichomonas vaginalis taga, putative 0.0127 0.0985 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0035 0.0139 0.0294
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Brugia malayi Melatonin receptor type 1A 0.0035 0.0139 0.0099
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0126 0.0972 0.2054
Loa Loa (eye worm) hypothetical protein 0.0378 0.3293 0.3265
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0139 0.0229
Schistosoma mansoni hypothetical protein 0.0035 0.0139 0.0229
Schistosoma mansoni smad1 5 8 and 0.0032 0.0112 0.0166
Loa Loa (eye worm) hypothetical protein 0.0127 0.0985 0.0948
Brugia malayi Dopamine receptor 0.0035 0.0139 0.0099
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0127 0.0985 1
Plasmodium vivax multidrug resistance protein 1, putative 0.0127 0.0985 1
Echinococcus multilocularis glutamate receptor 2 0.0024 0.004 0.0085
Echinococcus multilocularis serotonin receptor 0.0035 0.0139 0.0294
Loa Loa (eye worm) neuropeptide F receptor 0.0035 0.0139 0.0099
Trypanosoma cruzi PAB1-binding protein , putative 0.01 0.0732 0.056
Mycobacterium ulcerans component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 0.004 0.0182 0.1268
Schistosoma mansoni neuropeptide F-like receptor 0.0035 0.0139 0.0229
Loa Loa (eye worm) ABC transporter 0.004 0.0182 0.0143
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Brugia malayi latrophilin 2 splice variant baaae 0.0133 0.1036 0.0999
Echinococcus granulosus ankyrin repeat protein 0.0155 0.1241 0.2623
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0035 0.0139 0.0099
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0049 0.027 0.057
Schistosoma mansoni cathepsin D (A01 family) 0.0145 0.1152 0.2573
Brugia malayi multidrug resistance protein 3 0.0127 0.0985 0.0948
Echinococcus multilocularis adam 17 protease 0.018 0.1471 0.3108
Echinococcus granulosus fmrfamide receptor 0.0035 0.0139 0.0294
Entamoeba histolytica ATP-binding cassette protein, putative 0.004 0.0182 0.0013
Brugia malayi isocitrate dehydrogenase 0.0047 0.0249 0.021
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Trichomonas vaginalis ABC transporter, putative 0.0127 0.0985 1
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0127 0.0985 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0139 0.0229
Toxoplasma gondii hypothetical protein 0.0047 0.0252 0.0875
Echinococcus granulosus neuropeptide receptor A26 0.0035 0.0139 0.0294
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0139 0.0294
Echinococcus multilocularis sphingomyelin synthase protein 1 0.0058 0.0347 0.0733
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.004 0.0182 0.1268
Echinococcus granulosus tachykinin peptides receptor 99D 0.0321 0.2764 0.584
Echinococcus multilocularis multidrug resistance associated protein 7 0.004 0.0182 0.0385
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0229 0.192 0.1888
Mycobacterium ulcerans drugs-transport transmembrane ATP-binding protein ABC transporter 0.004 0.0182 0.1268
Brugia malayi hypothetical protein 0.0035 0.0139 0.0099
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0116 0.0881 0.1944
Plasmodium falciparum multidrug resistance protein 1 0.0127 0.0985 1
Toxoplasma gondii aspartyl protease ASP1 0.0049 0.027 0.1092
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0035 0.0139 0.0099
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0139 0.0229
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Loa Loa (eye worm) hypothetical protein 0.0133 0.1036 0.0999
Echinococcus granulosus multidrug resistance protein 1 0.0127 0.0985 0.2081
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0024 0.004 0.0085
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0058 0.0347 0.0308
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.004 0.0182 0.5
Trichomonas vaginalis ABC transporter, putative 0.0127 0.0985 1
Schistosoma mansoni glutamate receptor NMDA 0.0029 0.0083 0.0098
Entamoeba histolytica hypothetical protein 0.0058 0.0347 0.0188
Schistosoma mansoni hypothetical protein 0.0495 0.4363 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0127 0.0985 0.2081
Schistosoma mansoni multidrug resistance protein 0.0127 0.0985 0.2185
Echinococcus granulosus neuropeptide receptor 0.0035 0.0139 0.0294
Echinococcus granulosus glutamate receptor 2 0.0029 0.0083 0.0175
Brugia malayi G protein-coupled receptor F59B2.13 0.0035 0.0139 0.0099
Brugia malayi ABC transporter transmembrane region family protein 0.0038 0.017 0.013
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0047 0.0249 0.0835
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Entamoeba histolytica hypothetical protein 0.0058 0.0347 0.0188
Toxoplasma gondii isocitrate dehydrogenase 0.0047 0.0249 0.0835
Echinococcus multilocularis GPCR, family 2 0.0061 0.0381 0.0805
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0031 0.0104 0.0148
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Echinococcus multilocularis geminin 0.0495 0.4363 0.9217
Echinococcus multilocularis neuropeptide FF receptor 2 0.0035 0.0139 0.0294
Echinococcus granulosus nmda type glutamate receptor 0.0032 0.0111 0.0236
Trypanosoma brucei C-8 sterol isomerase, putative 0.1108 1 1
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0058 0.0347 0.2054
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Echinococcus granulosus g protein coupled receptor 0.0035 0.0139 0.0294
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0047 0.0249 0.0068
Echinococcus multilocularis G-protein coupled receptor, putative 0.0035 0.0139 0.0294
Echinococcus granulosus hypothetical protein 0.0035 0.0139 0.0294
Loa Loa (eye worm) hypothetical protein 0.0122 0.0934 0.0897
Brugia malayi MH1 domain containing protein 0.0032 0.0112 0.0072
Schistosoma mansoni peptidylglycine monooxygenase 0.0122 0.0934 0.2068
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 0.2517 0.2378
Echinococcus multilocularis neuropeptides capa receptor 0.0035 0.0139 0.0294
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Echinococcus granulosus G protein coupled receptor 139 0.0035 0.0139 0.0294
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0122 0.0934 0.0897
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0029 0.0083 0.0175
Brugia malayi ABC transporter family protein 0.0127 0.0985 0.0948
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0139 0.0229
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0035 0.0139 0.0229
Mycobacterium tuberculosis Probable drugs-transport transmembrane ATP-binding protein ABC transporter 0.004 0.0182 0.1268
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0547 0.4842 0.4746
Loa Loa (eye worm) neuropeptide F receptor 0.0035 0.0139 0.0099
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.004 0.0182 0.5
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0113 0.0855 0.1806
Brugia malayi Smad1 0.0032 0.0112 0.0072
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0029 0.0083 0.0175
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0035 0.0139 0.0099
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0035 0.0139 0.0099
Echinococcus granulosus biogenic amine 5HT receptor 0.0035 0.0139 0.0294
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0085 0.0598 0.129
Loa Loa (eye worm) hypothetical protein 0.004 0.0182 0.0143
Toxoplasma gondii LsmAD domain-containing protein 0.01 0.0732 0.6849
Plasmodium vivax aspartyl proteinase, putative 0.0049 0.027 0.1092
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0127 0.0985 1
Loa Loa (eye worm) hypothetical protein 0.0352 0.3047 0.3019
Echinococcus multilocularis fmrfamide receptor 0.0035 0.0139 0.0294
Schistosoma mansoni opsin-like receptor 0.0035 0.0139 0.0229
Brugia malayi Serotonin receptor 0.0035 0.0139 0.0099
Loa Loa (eye worm) Smad1 0.0032 0.0112 0.0072
Brugia malayi ABC transporter family protein 0.004 0.0182 0.0143
Plasmodium falciparum plasmepsin VI 0.0049 0.027 0.1092
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0035 0.0139 0.0099
Plasmodium vivax ataxin-2 like protein, putative 0.01 0.0732 0.6849
Loa Loa (eye worm) melatonin receptor type 1A 0.0035 0.0139 0.0099
Brugia malayi hypothetical protein 0.0035 0.0139 0.0099
Loa Loa (eye worm) MH2 domain-containing protein 0.0471 0.4148 0.4124
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0061 0.0381 0.0805
Schistosoma mansoni smad 0.0032 0.0112 0.0166
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0294 0.2517 0.2378
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Plasmodium vivax plasmepsin IV, putative 0.0049 0.027 0.1092
Echinococcus multilocularis smad 0.0032 0.0112 0.0236
Loa Loa (eye worm) MH2 domain-containing protein 0.0032 0.0112 0.0072
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0127 0.0985 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Loa Loa (eye worm) MH1 domain-containing protein 0.0032 0.0112 0.0072
Trichomonas vaginalis abcb9, putative 0.0127 0.0985 1
Schistosoma mansoni opsin-like receptor 0.0035 0.0139 0.0229
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0035 0.0139 0.0294
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.004 0.0182 0.5
Entamoeba histolytica hypothetical protein 0.004 0.0182 0.0013
Brugia malayi Serotonin receptor 0.0035 0.0139 0.0099
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0197 0.0015
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0029 0.0083 0.0175
Brugia malayi Dopamine receptor protein 1 0.0035 0.0139 0.0099
Loa Loa (eye worm) hypothetical protein 0.004 0.0182 0.0143
Entamoeba histolytica ATP-binding cassette protein, putative 0.004 0.0182 0.0013
Schistosoma mansoni biogenic amine (5HT) receptor 0.0035 0.0139 0.0229
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0049 0.027 0.0531
Loa Loa (eye worm) isocitrate dehydrogenase 0.0047 0.0249 0.021
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0127 0.0985 0.7897
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0099
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 0.0249 0.0527
Echinococcus multilocularis g-protein coupled receptor 0.0035 0.0139 0.0294
Onchocerca volvulus 0.0155 0.1244 0.3799
Giardia lamblia MRP-like ABC transporter 0.004 0.0182 0.0033
Schistosoma mansoni neuropeptide f receptor 76f 0.0035 0.0139 0.0229
Schistosoma mansoni biogenic amine receptor 0.0035 0.0139 0.0229
Brugia malayi hypothetical protein 0.0035 0.0139 0.0099
Brugia malayi hypothetical protein 0.0064 0.0408 0.0369
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0352 0.3047 1
Schistosoma mansoni dopamine-beta-monooxygenase 0.0122 0.0934 0.2068
Echinococcus multilocularis ATP binding cassette sub family B 0.004 0.0182 0.0385
Brugia malayi hypothetical protein 0.0155 0.1244 0.1209
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0127 0.0985 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.19 nM Inhibitory activity against HSV-2 Thymidine Kinase (HSV-2 TK) ChEMBL. 11425530
IC50 (binding) = 0.19 nM Inhibitory activity against HSV-2 Thymidine Kinase (HSV-2 TK) ChEMBL. 11425530
IC50 (binding) = 1.6 nM Inhibitory activity against HSV-1 Thymidine Kinase (HSV-1 TK) ChEMBL. 11425530
IC50 (binding) = 1.6 nM Inhibitory activity against HSV-1 Thymidine Kinase (HSV-1 TK) ChEMBL. 11425530

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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