Detailed information for compound 650570

Basic information

Technical information
  • TDR Targets ID: 650570
  • Name: 2-[(4-ethoxyphenyl)amino]-3-piperidin-1-ylnap hthalene-1,4-dione
  • MW: 376.448 | Formula: C23H24N2O3
  • H donors: 1 H acceptors: 2 LogP: 4.72 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)NC1=C(N2CCCCC2)C(=O)c2c(C1=O)cccc2
  • InChi: 1S/C23H24N2O3/c1-2-28-17-12-10-16(11-13-17)24-20-21(25-14-6-3-7-15-25)23(27)19-9-5-4-8-18(19)22(20)26/h4-5,8-13,24H,2-3,6-7,14-15H2,1H3
  • InChiKey: LUUNKBKVVOPXIS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(4-ethoxyphenyl)amino]-3-(1-piperidyl)naphthalene-1,4-dione
  • 2-[(4-ethoxyphenyl)amino]-3-piperidino-1,4-naphthoquinone
  • 2-[(4-ethoxyphenyl)amino]-3-piperidin-1-yl-naphthalene-1,4-dione
  • ZINC04063184
  • STOCK3S-05039

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii ABC1 family protein 0.0037 0.0105 0.4003
Schistosoma mansoni alpha-glucosidase 0.0136 0.1411 0.2223
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0047 0.0237 0.1216
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0105 0.0203
Schistosoma mansoni intermediate filament proteins 0.0055 0.0343 0.0522
Onchocerca volvulus Putative hydrolase PNKD 0.0047 0.0239 0.04
Loa Loa (eye worm) hypothetical protein 0.0037 0.0105 0.0199
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0343 0.0676
Loa Loa (eye worm) hypothetical protein 0.0037 0.0105 0.0199
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0104 0.0165
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0078 0.013
Echinococcus multilocularis zinc phosphodiesterase 0.0047 0.0239 0.0225
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0047 0.0237 0.9899
Trichomonas vaginalis beta lactamase domain, putative 0.0047 0.0239 0.0594
Echinococcus granulosus zinc phosphodiesterase 0.0047 0.0239 0.038
Loa Loa (eye worm) hypothetical protein 0.003 0.0015 0.002
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0105 0.0098
Entamoeba histolytica hypothetical protein, conserved 0.0047 0.0239 0.1233
Mycobacterium tuberculosis Conserved protein 0.0047 0.0239 0.051
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0047 0.0237 0.1216
Onchocerca volvulus 0.0037 0.0105 0.016
Mycobacterium tuberculosis Conserved hypothetical protein 0.0047 0.0239 0.051
Giardia lamblia Metallo-beta-lactamase superfamily protein 0.0047 0.0239 0.5
Loa Loa (eye worm) hypothetical protein 0.0408 0.5001 1
Entamoeba histolytica hypothetical protein 0.0037 0.0104 0.02
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0105 0.0098
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0047 0.0239 0.1233
Onchocerca volvulus 0.024 0.2786 0.4943
Schistosoma mansoni hypothetical protein 0.0506 0.6295 1
Onchocerca volvulus 0.0037 0.0105 0.016
Onchocerca volvulus 0.0455 0.5622 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0087 0.0762 0.0748
Echinococcus multilocularis geminin 0.0506 0.6295 0.629
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0104 0.0142
Leishmania major hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative 0.0047 0.0239 0.1233
Loa Loa (eye worm) hypothetical protein 0.0037 0.0105 0.0199
Brugia malayi hypothetical protein 0.0047 0.0237 0.0413
Trypanosoma cruzi aminopeptidase, putative 0.0134 0.1383 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0134 0.1383 0.2198
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.1702 0.1689
Schistosoma mansoni hypothetical protein 0.0506 0.6295 1
Loa Loa (eye worm) aminopeptidase N 0.0134 0.1383 0.2759
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0134 0.1383 0.1371
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0134 0.1383 0.482
Brugia malayi Peptidase family M1 containing protein 0.0455 0.5622 1
Echinococcus multilocularis lamin dm0 0.0055 0.0343 0.0328
Schistosoma mansoni hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) 0.0047 0.0239 0.0357
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0276 0.0417
Trypanosoma brucei cleavage and polyadenylation specificity factor subunit, putative 0.0047 0.0239 0.1233
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0047 0.0239 0.1233
Toxoplasma gondii aminopeptidase N, putative 0.0047 0.0237 0.9899
Brugia malayi Peptidase family M1 containing protein 0.0134 0.1383 0.2454
Trichomonas vaginalis beta lactamase domain, putative 0.0047 0.0239 0.0594
Loa Loa (eye worm) hypothetical protein 0.0035 0.0071 0.0133
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0134 0.1383 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0105 0.0199
Treponema pallidum ribonuclease Z 0.0047 0.0239 0.5
Entamoeba histolytica hypothetical protein 0.0037 0.0104 0.02
Mycobacterium ulcerans Zn-dependent glyoxylase 0.0047 0.0239 0.1052
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0076 0.0619 0.0962
Loa Loa (eye worm) hypothetical protein 0.0087 0.0762 0.1515
Onchocerca volvulus 0.0091 0.0822 0.1439
Schistosoma mansoni hypothetical protein 0.0035 0.0071 0.009
Echinococcus multilocularis aminopeptidase N 0.0455 0.5622 0.5616
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0047 0.0237 0.0376
Brugia malayi hypothetical protein 0.0037 0.0104 0.0177
Mycobacterium ulcerans hydrolase 0.0047 0.0239 0.1052
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0087 0.0762 0.1189
Loa Loa (eye worm) hypothetical protein 0.0037 0.0105 0.0199
Loa Loa (eye worm) carboxylesterase 0.0076 0.0619 0.1229
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0134 0.1383 0.482
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0134 0.1383 1
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0047 0.0239 0.1233
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.2401 0.4797
Loa Loa (eye worm) hypothetical protein 0.0047 0.0239 0.0469
Echinococcus granulosus acetylcholinesterase 0.0076 0.0619 0.0983
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0237 0.2742 1
Schistosoma mansoni zinc phosphodiesterase 0.0047 0.0239 0.0357
Mycobacterium ulcerans glyoxalase II, GloB 0.0047 0.0239 0.1052
Trypanosoma cruzi glyoxalase II 0.0047 0.0239 0.1233
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0134 0.1383 0.1371
Brugia malayi beta-lactamase family protein 0.0037 0.0105 0.0177
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0239 0.0594
Schistosoma mansoni lamin 0.0055 0.0343 0.0522
Loa Loa (eye worm) metallo-beta-lactamase superfamily protein 0.0047 0.0239 0.0469
Loa Loa (eye worm) hypothetical protein 0.0054 0.0329 0.065
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0105 0.0143
Trypanosoma brucei Aminopeptidase M1, putative 0.0134 0.1383 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0078 0.0146
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0105 0.0098
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0134 0.1383 0.2198
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0239 0.0594
Mycobacterium ulcerans hydrolase 0.0047 0.0239 0.1052
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0105 0.0199
Echinococcus granulosus carboxylesterase 5A 0.0076 0.0619 0.0983
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0134 0.1383 0.1371
Schistosoma mansoni hypothetical protein 0.0047 0.0239 0.0357
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0047 0.0239 0.1233
Brugia malayi MH2 domain containing protein 0.024 0.2788 0.4954
Echinococcus granulosus aminopeptidase N 0.0455 0.5622 0.8931
Plasmodium falciparum cytosolic glyoxalase II 0.0047 0.0239 1
Schistosoma mansoni hypothetical protein 0.0047 0.0239 0.0357
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0047 0.0237 0.0376
Mycobacterium leprae conserved hypothetical protein 0.0047 0.0239 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0134 0.1383 0.2198
Schistosoma mansoni alpha glucosidase 0.0035 0.0078 0.0101
Loa Loa (eye worm) MH2 domain-containing protein 0.024 0.2788 0.5571
Onchocerca volvulus 0.0047 0.0237 0.0396
Mycobacterium tuberculosis Possible hydrolase 0.0047 0.0239 0.051
Loa Loa (eye worm) hypothetical protein 0.0047 0.0237 0.0464
Brugia malayi Carboxylesterase family protein 0.0076 0.0619 0.1093
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0047 0.0239 0.0225
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0104 0.009
Loa Loa (eye worm) TATA binding protein associated factor 0.0047 0.0237 0.0464
Trypanosoma cruzi glyoxalase II 0.0047 0.0239 0.1233
Echinococcus multilocularis musashi 0.0055 0.0343 0.0328
Brugia malayi hypothetical protein 0.0134 0.1383 0.2454
Echinococcus multilocularis acetylcholinesterase 0.0076 0.0619 0.0605
Loa Loa (eye worm) hypothetical protein 0.0047 0.0239 0.0469
Loa Loa (eye worm) hypothetical protein 0.0047 0.0239 0.0469
Leishmania major metallo-beta-lactamase family protein-like protein 0.0047 0.0239 0.1233
Mycobacterium leprae conserved hypothetical protein 0.0047 0.0239 1
Schistosoma mansoni hypothetical protein 0.0037 0.0104 0.0142
Echinococcus granulosus leukotriene A 4 hydrolase 0.0047 0.0237 0.0376
Echinococcus multilocularis lamin 0.0055 0.0343 0.0328
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0282 0.0494
Onchocerca volvulus 0.0037 0.0105 0.016
Echinococcus granulosus lamin 0.0055 0.0343 0.0544
Leishmania major hypothetical protein, conserved 0.0047 0.0239 0.1233
Echinococcus multilocularis hydroxyacylglutathione hydrolase 0.0047 0.0239 0.0225
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0047 0.0239 0.038
Loa Loa (eye worm) hypothetical protein 0.0051 0.0282 0.0556
Onchocerca volvulus 0.0055 0.0343 0.0585
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0047 0.0237 0.0464
Loa Loa (eye worm) hydroxyacylglutathione hydrolase cytoplasmic 0.0047 0.0239 0.0469
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0343 0.0676
Trypanosoma cruzi Aminopeptidase M1, putative 0.0134 0.1383 1
Schistosoma mansoni hypothetical protein 0.0047 0.0239 0.0357
Schistosoma mansoni alpha-glucosidase 0.0136 0.1411 0.2223
Echinococcus granulosus lamin dm0 0.0055 0.0343 0.0544
Mycobacterium tuberculosis Beta lactamase like protein 0.0047 0.0239 0.051
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0047 0.0239 0.5
Chlamydia trachomatis ribonuclease Z 0.0047 0.0239 0.5
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0047 0.0239 0.1233
Onchocerca volvulus 0.0047 0.0239 0.04
Loa Loa (eye worm) peptidase family M1 containing protein 0.0368 0.4476 0.8949
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0047 0.0237 0.0354
Loa Loa (eye worm) transcription factor SMAD2 0.024 0.2788 0.5571
Brugia malayi Pre-SET motif family protein 0.0211 0.2401 0.4266
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0105 0.0166
Mycobacterium tuberculosis Conserved hypothetical protein 0.0047 0.0239 0.051
Trypanosoma brucei Aminopeptidase M1, putative 0.0134 0.1383 1
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0047 0.0237 0.0354
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0047 0.0237 0.1216
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0047 0.0239 0.1233
Brugia malayi ethe1-prov protein 0.0047 0.0239 0.0417
Brugia malayi TATA binding protein associated factor 0.0047 0.0237 0.0413
Entamoeba histolytica type A flavoprotein, putative 0.0047 0.0239 0.1233
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0134 0.1383 0.1371
Trypanosoma brucei metallo-beta-lactamase-like protein, putative 0.0047 0.0239 0.1233
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0158 0.1702 0.3396
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0282 0.0556
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0105 0.0203
Trichomonas vaginalis beta lactamase domain, putative 0.0047 0.0239 0.0594
Entamoeba histolytica hypothetical protein 0.0037 0.0104 0.02
Schistosoma mansoni zinc phosphodiesterase 0.0047 0.0239 0.0357
Trichomonas vaginalis esterase, putative 0.0037 0.0105 0.0098
Brugia malayi Pre-SET motif family protein 0.003 0.0015 0.0018
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0047 0.0237 0.1216
Leishmania major metallo-beta-lactamase family-like protein 0.0047 0.0239 0.1233
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0015 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0239 0.0594
Mycobacterium ulcerans hypothetical protein 0.0047 0.0239 0.1052
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0087 0.0762 0.5237
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0343 0.0601
Brugia malayi metallo-beta-lactamase superfamily protein 0.0047 0.0239 0.0417
Onchocerca volvulus 0.0055 0.0343 0.0585
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0105 0.009
Trypanosoma brucei hydroxyacylglutathione hydrolase, putative 0.0047 0.0239 0.1233
Loa Loa (eye worm) hypothetical protein 0.0076 0.0619 0.1229
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0047 0.0237 0.0586
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0134 0.1383 0.2179
Mycobacterium tuberculosis Conserved hypothetical protein 0.0047 0.0239 0.051
Brugia malayi Carboxylesterase family protein 0.0076 0.0619 0.1093
Trichomonas vaginalis beta lactamase domain, putative 0.0047 0.0239 0.0594
Echinococcus granulosus ETHE1 protein 0.0047 0.0239 0.038
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0239 0.0594
Loa Loa (eye worm) hypothetical protein 0.0055 0.0343 0.0676
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0078 0.2823
Mycobacterium ulcerans hydrolase 0.0047 0.0239 0.1052
Entamoeba histolytica alkyl sulfatase, putative 0.0047 0.0239 0.1233
Echinococcus multilocularis carboxylesterase 5A 0.0076 0.0619 0.0605
Entamoeba histolytica metallo-beta-lactamase family protein 0.0047 0.0239 0.1233
Schistosoma mansoni lamin 0.0055 0.0343 0.0522
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0047 0.0237 0.9899
Mycobacterium ulcerans hypothetical protein 0.0047 0.0239 0.1052
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0047 0.0237 0.0222
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0047 0.0239 0.1233
Schistosoma mansoni aminopeptidase A (M01 family) 0.0047 0.0237 0.0354
Loa Loa (eye worm) acetylcholinesterase 1 0.0076 0.0619 0.1229
Plasmodium vivax unspecified product 0.0047 0.0239 1
Onchocerca volvulus 0.0047 0.0239 0.04
Mycobacterium tuberculosis Possible hydrolase 0.0047 0.0239 0.051
Mycobacterium ulcerans aminopeptidase N PepN 0.0047 0.0237 0.1034
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0071 0.0118
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0078 0.0063
Mycobacterium leprae POSSIBLE HYDROLASE 0.0047 0.0239 1
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0105 0.0098
Echinococcus granulosus geminin 0.0506 0.6295 1
Mycobacterium ulcerans hypothetical protein 0.0047 0.0239 0.1052
Brugia malayi beta-lactamase family protein 0.0037 0.0105 0.0177
Entamoeba histolytica alkyl sulfatase, putative 0.0047 0.0239 0.1233
Echinococcus granulosus lysosomal alpha glucosidase 0.0158 0.1702 0.2703
Entamoeba histolytica metallo-beta-lactamase family protein 0.0047 0.0239 0.1233
Loa Loa (eye worm) beta-lactamase 0.0037 0.0105 0.0199
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.1702 0.1689
Loa Loa (eye worm) hypothetical protein 0.0076 0.0619 0.1229
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0134 0.1383 0.1371
Brugia malayi Peptidase family M1 containing protein 0.0047 0.0237 0.0413
Mycobacterium tuberculosis Conserved protein 0.0047 0.0239 0.051
Echinococcus multilocularis acetylcholinesterase 0.0076 0.0619 0.0605
Loa Loa (eye worm) hypothetical protein 0.0047 0.0237 0.0464
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0047 0.0239 0.038
Echinococcus granulosus hydroxyacylglutathione hydrolase 0.0047 0.0239 0.038
Brugia malayi intermediate filament protein 0.0055 0.0343 0.0601
Loa Loa (eye worm) hydroxyacylglutathione hydrolase 0.0047 0.0239 0.0469
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0134 0.1383 1
Leishmania major cleavage and polyadenylation specificity factor, putative 0.0047 0.0239 0.1233
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0047 0.0237 0.1216
Onchocerca volvulus 0.005 0.0276 0.0467
Plasmodium vivax hydroxyacyl glutathione hydrolase, putative 0.0047 0.0239 1
Brugia malayi beta-lactamase 0.0037 0.0105 0.0177
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0047 0.0239 0.5
Loa Loa (eye worm) hypothetical protein 0.0047 0.0239 0.0469
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0047 0.0239 0.0594
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0134 0.1383 1
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0239 0.0594
Brugia malayi hypothetical protein 0.0047 0.0239 0.0417
Mycobacterium ulcerans aminopeptidase N PepN 0.0134 0.1383 1
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0047 0.0237 0.1216
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0134 0.1383 0.2179
Leishmania major hypothetical protein, conserved 0.0037 0.0105 0.0203
Toxoplasma gondii hydroxyacylglutathione hydrolase 0.0047 0.0239 1
Echinococcus granulosus acetylcholinesterase 0.0076 0.0619 0.0983
Onchocerca volvulus Hydroxyacylglutathione hydrolase, mitochondrial homolog 0.0047 0.0239 0.04
Entamoeba histolytica metallo-beta-lactamase family protein 0.0047 0.0239 0.1233
Entamoeba histolytica type A flavoprotein, putative 0.0047 0.0239 0.1233
Echinococcus granulosus intermediate filament protein 0.0055 0.0343 0.0544
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0105 0.0098
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0105 0.0143
Brugia malayi metallo-beta-lactamase superfamily protein 0.0047 0.0239 0.0417
Toxoplasma gondii aminopeptidase n, putative 0.0047 0.0237 0.9899
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0105 0.0203
Mycobacterium leprae Beta-lactamase-like protein 0.0047 0.0239 1
Brugia malayi Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. 0.0047 0.0239 0.0417
Trypanosoma cruzi aminopeptidase, putative 0.0047 0.0237 0.1216
Onchocerca volvulus 0.0134 0.1383 0.2441
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0078 0.0124
Trichomonas vaginalis beta lactamase domain, putative 0.0047 0.0239 0.0594
Trypanosoma brucei aminopeptidase, putative 0.0047 0.0237 0.1216
Mycobacterium tuberculosis Conserved protein 0.0047 0.0239 0.051
Toxoplasma gondii aminopeptidase N protein 0.0047 0.0237 0.9899
Echinococcus multilocularis tumor protein p63 0.0342 0.4134 0.4125
Loa Loa (eye worm) hypothetical protein 0.0087 0.0762 0.1515
Loa Loa (eye worm) hypothetical protein 0.0037 0.0105 0.0199
Trichomonas vaginalis A-type flavoprotein 0.0047 0.0239 0.0594
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0134 0.1383 0.2198
Brugia malayi Glycosyl hydrolases family 31 protein 0.0158 0.1702 0.302
Trichomonas vaginalis set domain proteins, putative 0.024 0.2786 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0282 0.0494
Loa Loa (eye worm) hypothetical protein 0.005 0.0276 0.0544
Trypanosoma brucei glyoxalase II 0.0047 0.0239 0.1233
Toxoplasma gondii metallo-beta-lactamase domain-containing protein 0.0047 0.0239 1
Loa Loa (eye worm) hypothetical protein 0.0321 0.3854 0.7705
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0047 0.0239 0.0225
Trypanosoma cruzi glyoxalase II 0.0047 0.0239 0.1233
Entamoeba histolytica aminopeptidase, putative 0.0134 0.1383 1
Trichomonas vaginalis beta lactamase domain, putative 0.0047 0.0239 0.0594
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0105 0.4003
Trichomonas vaginalis apoptosis inducing factor, putative 0.0047 0.0239 0.0594
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0134 0.1383 0.1371
Mycobacterium ulcerans beta lactamase-like protein 0.0047 0.0239 0.1052
Wolbachia endosymbiont of Brugia malayi metallo-beta-lactamase superfamily hydrolase 0.0047 0.0239 0.5
Loa Loa (eye worm) hypothetical protein 0.0047 0.0237 0.0464
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0239 0.0594
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0047 0.0239 0.1233
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0105 0.0177
Echinococcus granulosus tumor protein p63 0.0342 0.4134 0.6567
Echinococcus multilocularis ETHE1 protein 0.0047 0.0239 0.0225
Mycobacterium ulcerans hypothetical protein 0.0047 0.0239 0.1052
Entamoeba histolytica hypothetical protein 0.0037 0.0104 0.02

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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